Allergy Asthma and Clinical Immunology

Article	Citations
Hereditary angioedema with an acute attack resolved after bone marrow transplantation for acute myeloid leukemia: a case report	51
Drug allergy	47
Proceedings of the Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2020	45
Characteristics of older adult hospitalized patients with bronchial asthma: a retrospective study	39
Real-world association between systemic corticosteroid exposure and complications in US patients with severe asthma	28
Effectiveness and safety of allergen immunotherapy in patients with allergic rhinitis complicated by rheumatic autoimmune diseases: a case series study	27
Early diagnosis of hereditary angioedema in children: genetic testing should be prioritized	25
Mental health problems associated with idiopathic anaphylaxis	25
The effect of Co-Q10 on allergic rhinitis and allergic asthma	24
Long-term efficacy of anti-IL-4 receptor antibody in a patient with aspirin-exacerbated respiratory disease and IgG4-related disease	21
Primary prevention of food allergy: beyond early introduction	20
MiRNA-221-5p suppressed the Th17/Treg ratio in asthma via RORγt/Foxp3 by targeting SOCS1	18
Optimizing pediatric asthma education using virtual platforms during the COVID-19 pandemic	18
Pre-existing asthma as a comorbidity does not modify cytokine responses and severity of COVID-19	17
Assessment of changes in genetic transcriptome in nasal epithelial cells exposed to ozone-aged black carbon and pollen allergen by high-throughput transcriptomics	17
Oral immunotherapy improves the quality of life of adults with food allergy	17
HealthSWEDE: costs with sublingual immunotherapy—a Swedish questionnaire study	17
Childhood allergic diseases across geographical regions of Kandy and Anuradhapura districts of Sri Lanka; where do the rates stand among other regions: experience from Global asthma network Phase 1 st	16
Epidemiology of comorbidities and their association with asthma control	16
Development and initial validation of a modified lymphocyte transformation test (LTT) assay in patients with DRESS and AGEP	15
No impact of helminth coinfection in patients with smear positive tuberculosis on immunoglobulin levels using a novel method measuring Mycobacterium tuberculosis-specific antibodies	15
Identification of gene biomarkers with expression profiles in patients with allergic rhinitis	15
Early intervention of atopic dermatitis as a preventive strategy for progression of food allergy	14
Immune response after SARS-CoV-2 vaccination in patients with inflammatory immune-mediated diseases receiving immunosuppressive treatment	14
Correction: Fexofenadine: review of safety, efficacy and unmet needs in children with allergic rhinitis	14

Validation of adult asthma case definitions for primary care sentinel surveillance	13
Sensitization to avian and fungal proteins in different work environments	13
Understanding attitudes and obstacles to vaccination against COVID-19 in patients with primary immunodeficiency	12
Content analysis of promotional material for asthma-related products and therapies on Instagram	12
Physician education on World Asthma Day aids in disease management during the COVID-19	12
Therapeutic potential of the topical recombinant human interleukin-1 receptor antagonist in guinea pigs with allergic rhinitis	12
Identification of candidate aberrant differentially methylated/expressed genes in asthma	12
Practical challenges in oral immunotherapy resolved through patient-centered care	12
miR-3934 regulates the apoptosis and secretion of inflammatory cytokines of basophils via targeting RAGE in asthma	12
A rare immunological disease, caspase 8 deficiency: case report and literature review	12
Immune endotyping and gene expression profile of patients with chronic rhinosinusitis with nasal polyps in the aspirin-exacerbated respiratory disease (AERD) and the non-AERD subgroups	11
Oropharyngeal symptoms without systemic reactions as a risk factor for food allergen intolerance: a longitudinal pediatric study	11
DRESS induced by amoxicillin-clavulanate in two pediatric patients confirmed by lymphocyte toxicity assay	11
A novel pathogenetic factor of laryngeal attack in hereditary angioedema? Involvement of protease activated receptor 1	11
Patient outcomes associated with subcutaneous C1INH prophylaxis for hereditary angioedema: a retrospective analysis	11
Kimura’s disease with recurrent bilateral lacrimal gland involvement in a male Japanese child successfully treated with cyclosporine A	11
Update on the association between Helicobacter pylori infection and asthma in terms of microbiota and immunity	10
Rare and heterogeneous manifestations of leucocyte adhesion deficiency type 1: report of two cases with diagnostic dilemmas and novel ITGB2 mutation	10
Efficacy of probiotics as adjuvant therapy in bronchial asthma: a systematic review and meta-analysis	10
CD8+ Tregs ameliorate inflammatory reactions in a murine model of allergic rhinitis	10
Delayed presentation of food protein-induced enterocolitis syndrome (FPIES) to okra in a toddler	10
Methylprednisolone-induced anaphylaxis diagnosed by intradermal skin test: a case report	10
Allergic reactions to emerging food allergens in Canadian children	10
Economic impact of self-administered subcutaneous versus clinic-administered intravenous immunoglobulin G therapy in Alberta, Canada: a population-based cohort study	9
Underestimation of airway luminal eosinophilia by quantitative sputum cytometry	9
Association between constipation and the development of asthma: a meta-analysis	9
Severe congenital neutropenia due to G6PC3 deficiency: early and delayed phenotype of a patient	9
Expression levels of plasma exosomal miR-124, miR-125b, miR-133b, miR-130a and miR-125b-1-3p in severe asthma patients and normal individuals with emphasis on inflammatory factors	9
Upregulated expression of Notch1/4 - JAG-1/DLL-1 detected in allergic rhinitis	9
Adjunct therapy with probiotics for chronic urticaria in children: randomised placebo-controlled trial	9
The controversial effect of smoking and nicotine in SARS-CoV-2 infection	9
Management of allergic rhinitis with leukotriene receptor antagonists versus selective H1-antihistamines: a meta-analysis of current evidence	9
Anaphylactic and nonanaphylactic reactions to SARS-CoV-2 vaccines: a systematic review and meta-analysis	9
Osthole attenuates asthma-induced airway epithelial cell apoptosis and inflammation by suppressing TSLP/NF-κB-mediated inhibition of Th2 differentiation	8
The STAT6 inhibitor AS1517499 reduces the risk of asthma in mice with 2,4-dinitrochlorobenzene-induced atopic dermatitis by blocking the STAT6 signaling pathway	8
Angioedema	8
Leveraging unstructured data to identify hereditary angioedema patients in electronic medical records	8
Correction: Considerations in the management of hereditary angioedema due to C1-INH deficiency in women of childbearing age	8
Genetic links between atopy, allergy, and alopecia areata: insights from a Mendelian randomization study	8
The cow’s milk allergy that wasn’t: allergy to supplemental oral lactase enzyme	8
The excess costs of childhood food allergy on Canadian families: a cross-sectional study	8
Intestinal helminthic infection and allergic disorders among school children enrolled in mass deworming program, Sululta, Ethiopia	8
The use of dupilumab in severe atopic dermatitis during pregnancy: a case report	8
The prevalence of obstructive sleep apnea in Japanese asthma patients	8
Anaphylaxis	8
Minimum number and types of allergens for a skin prick test panel in Thai children with allergic respiratory diseases	8
13th C1-inhibitor deficiency and angioedema workshop—2023	8
Guardian’s knowledge and attitude towards inhaled corticosteroids aerosol therapy and medication compliance of children with wheezing diseases	8
2023 CSACI annual scientific meeting book of abstracts	8
Effectiveness and safety of lanadelumab in ethnic and racial minority subgroups of patients with hereditary angioedema: results from phase 3 studies	7

Atopic dermatitis	7
Infusion parameters, safety, and practical guidance for the manual administration of subcutaneous immunoglobulin 20% (Ig20Gly)	7
Retraction Note: Clinical and immuno-proteomic approach on lantana camara pollen allergy—a major health hazard	7
The complexities of decision-making associated with on-demand treatment of hereditary angioedema (HAE) attacks	7
Eosinophilic esophagitis	7
Liver enzyme elevation and eosinophilia with atorvastatin: a case of probable DRESS without cutaneous symptoms	7
Immunoglobulin E (IgE)-mediated food allergy	7
Real-world experience: a retrospective pediatric chart review to determine why patients and caregivers discontinue oral immunotherapy	7
Stellate ganglion block as an intervention in refractory eosinophilic granulomatosis with polyangiitis: a case report	7
Several Nocardia abcessus bronchiolitis in a patient treated with inhaled corticosteroids: a case report	7
Immunoglobulin utilization in Canada: a comparative analysis of provincial guidelines and a scoping review of the literature	6
Safety and effectiveness of the Canadian food ladders for children with IgE-mediated food allergies to cow’s milk and/or egg	6
Temporal examination of adult food insecurity amongst Canadian families managing food allergy	6
fSCIG 10% in pediatric primary immunodeficiency diseases: a European post-authorization safety study	6
Neonatal abstinence syndrome is a potential cause of low TREC copy number	6
Psychosocial burden of type 1 and 2 hereditary angioedema: a single-center Canadian cohort study	6
Autoantibodies to speckled protein family in primary biliary cholangitis	6
Malignancy and immune disorders in patients with hereditary angioedema	6
Growth in diagnosis and treatment of primary immunodeficiency within the global Jeffrey Modell Centers Network	6
Inhaled corticosteroids do not affect the antibody titer against the SARS-CoV-2 spike protein in BNT162b2 mRNA vaccinated patients	6
RETRACTED ARTICLE: MicroRNA-29 mediates anti-inflammatory effects and alleviation of allergic responses and symptoms in mice with allergic rhinitis	6
The prevalence of gastrointestinal symptoms and cobalamin deficiency in patients with chronic urticaria	6
Exploration of parent-reported food allergy symptoms via breastmilk exposures and likelihood to develop tolerance	6
Seronegative immunity to SARS-CoV-2: a case study	6
Diversity of malignancies in patients with different types of inborn errors of immunity	6
Hereditary angioedema due to C1 inhibitor deficiency: real-world experience from the Icatibant Outcome Survey in Spain	6
The frequencies of peripheral blood CD5+CD19+ B cells, CD3−CD16+CD56+ NK, and CD3+CD56+ NKT cells and serum interleukin-10 in patients with multiple sclerosis and neuromyelitis optica spectrum disorde	6
Inborn errors of immunity in adulthood	6
Successful mRNA COVID-19 vaccination in a patient with a history of severe polyethylene glycol anaphylaxis	6
CMV retinitis in patients on mycophenolate immunosuppression: a report of two cases	6
Bronchial thermoplasty in severe asthma: a real-world study on efficacy and gene profiling	6
Patient education in atopic dermatitis: a scoping review	5
Dietary exposures and allergy prevention in high-risk infants	5
The complexities of insulin allergy: a case and approach	5
Volatile organic breath components and exercise induced bronchoconstriction in asthmatic children	5
Prevalence of adult eczema, hay fever, and asthma, and associated risk factors: a population-based study in the northern Grassland of China	5
Accelerometer-derived sleep metrics in mild and difficult-to-treat asthma	5
Myelin oligodendrocyte glycoprotein antibody-associated disease as a novel presentation of central nervous system autoimmunity in a pediatric patient with Wiskott-Aldrich syndrome	5
Kimura disease with Allergic Bronchopulmonary Aspergillosis: a case report	5
Associations of Helicobacter pylori and hepatitis A seropositivity with asthma in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): addressing the hygiene hypothesis	5
Cardiovascular comorbidities of atopic dermatitis: using National Health Insurance data in Korea	5
Evaluation of adherence to guideline-directed therapy and risk factors for exacerbation in mild asthma: a retrospective chart review	5
A case report of acute food protein-induced enterocolitis syndrome to walnut	5
Clinical and demographic pattern of chronic granulomatous disease (CGD) from a multicenter perspective: Malaysia’s experience over 26 years	5
Insights into urticaria in pediatric and adult populations and its management with fexofenadine hydrochloride	5
Considerations for transition from subcutaneous to oral prophylaxis in the treatment of hereditary angioedema	5
Expression profiling of ileal mucosa in asthma reveals upregulation of innate immunity and genes characteristic of Paneth and goblet cells	5
Parental perceptions of a novel subsidy program to address the financial burden of milk allergy: a qualitative study	5
Assessment and management of disease burden and quality of life in patients with hereditary angioedema: a consensus report	5
It takes a village: perceptions of Winnipeg parents, students, teachers and school staff regarding the impact of food allergy on school-age students and their families	5
The pharmacokinetics of epinephrine/adrenaline autoinjectors	5
Long-term prophylaxis with lanadelumab for HAE: authorization for temporary use in France	5
A case report of fatal anaphylaxis on first exposure to rasburicase just before lymphoma treatment	5
Recommendations from a Canadian Delphi consensus study on best practice for optimal referral and appropriate management of severe asthma	5
Two cases of transplant-acquired food allergy who developed resensitization after a negative oral food challenge	5
Allergen immunotherapy	4
Serum autophagy protein 5 is positively related to T helper 2/T helper 1 ratio, inflammation, and exacerbation in adult asthma patients	4
Prurigo Nodularis onset during secukinumab treatment of psoriasis: a case report	4
Retraction Note: MicroRNA-29 mediates anti-inflammatory effects and alleviation of allergic responses and symptoms in mice with allergic rhinitis	4
Fibrosing mediastinitis in a child with Mendelian susceptibility to mycobacterial disease possibly due to Bacillus Calmette-Guérin	4
Two cases of dupilumab-associated conjunctivitis with high expression of IL-8 mRNA on the ocular surface: a case report	4
What is the impact of birth weight corrected for gestational age on later onset asthma: a meta-analysis	4
Treatment of idiopathic anaphylaxis with dupilumab: a case report	4
The first reported case of Blaptica dubia cockroach allergy	4
Attenuated androgen discontinuation in patients with hereditary angioedema: a commented case series	4
Technical validation of controlled exposure to cat dander in the specialized particulate control environmental exposure unit (SPaC-EEU)	4
The efficacy and safety of stepwise oral food challenge in children with hen’s egg allergy	4
Correction to: Insights into urticaria in pediatric and adult populations and its management with fexofenadine hydrochloride	4
Failure of a single day metronidazole desensitization protocol, and success of a modified two-day protocol in an outpatient setting	4
CFTR heterozygosity in severe asthma with recurrent airway infections: a retrospective review	4
Toxic epidermal necrosis associated with phenobarbitone: a case report and brief review of the literatures	4
Monoclonal antibody treatment of COVID-19 in a pregnant woman with common variable immunodeficiency	4
Nasal mucosal reactivity assessment via a double-blind placebo-controlled food challenge with cow’s milk allergens	4
First patient in the Iranian Registry with novel DOCK2 gene mutation, presenting with skeletal tuberculosis, and review of literature	4
Taurine promotes the production of CD4+CD25+FOXP3+ Treg cells through regulating IL-35/STAT1 pathway in a mouse allergic rhinitis model	4
Developing and disseminating an electronic penicillin allergy de-labelling tool using the model for improvement framework	4
A prognosis prediction chromatin regulator signature for patients with severe asthma	4
Effect of omalizumab for autoimmune progesterone dermatitis refractory to bilateral oophorectomy: a case report	4
Intravenous immunoglobulins improve live birth rate among women with underlying immune conditions and recurrent pregnancy loss: a systematic review and meta-analysis	4
Anti-ganglioside antibodies and celiac disease	4

A case of hand urticaria, lip angioedema, and oropharyngeal pruritus induced by Japanese radish through IgE-mediated immediate allergic reaction	4
Impact of lanadelumab in hereditary angioedema: a case series of 12 patients in Canada	4
Randomized controlled trial of ragweed sublingual immunotherapy tablet in the subpopulation of Canadian children and adolescents with allergic rhinoconjunctivitis	4
Exploratory pharmacodynamics and efficacy of PF-06817024 in a Phase 1 study of patients with chronic rhinosinusitis and atopic dermatitis	4
Resource utilization and cost assessment of a proactive penicillin allergy de-labeling program for low-risk inpatients	4
Impact of antigen avoidance test for fibrotic hypersensitivity pneumonitis in stable phase	3
Plumbagin attenuates Bleomycin-induced lung fibrosis in mice	3
“There definitely should be some more help for families”: a call for federal support for families managing pediatric food allergy	3
Eosinophilic gastritis and gluten-sensitive enteropathy manifested as hypoproteinemia and treated with omalizumab: a case report	3
Comparison of weight per volume and protein nitrogen units in non-standardized allergen extracts: implications for prescribing subcutaneous immunotherapy	3
The value of clinical observation: sleuthing for allergies on the front lines	3
Interaction between early-life pet exposure and methylation pattern of ADAM33 on allergic rhinitis among children aged 3–6 years in China	3
Improvement of peripheral neuropathy in a patient with antineutrophil cytoplasmic antibody-negative eosinophilic granulomatosis with polyangiitis by additional mepolizumab	3
Utility of eConsults for COVID-19 vaccine-related concerns in Ontario: a cross-sectional analysis	3
Rupatadine to prevent local allergic reactions to sublingual allergy immunotherapy: a case series	3
Outcome of a de-labelling algorithm compared with results of penicillin (β-lactam) allergy testing	3
Intranasal budesonide for rhinitis during a high airborne pollution period: a randomized controlled trial	3
Cow’s milk allergy skin tests: fresh milk, commercial extracts, or both?	3
Development of a primary care screening algorithm for the early detection of patients at risk of primary antibody deficiency	3
Correction: Transitioning subcutaneous immunoglobulin 20% therapies in patients with primary and secondary immunodeficiencies: Canadian real‑world study	3
Primary prescription adherence for obstructive lung disease in a primary care population	3
Asymptomatic surveillance testing for COVID-19 in health care professional students: lessons learned from a low prevalence setting	3
COVID-19 risk perception and vaccine acceptance in individuals with self-reported chronic respiratory or autoimmune conditions	3
Demographic, clinical, immunological, and molecular features of iranian national cohort of patients with defect in DCLRE1C gene	3
The new era of add-on asthma treatments: where do we stand?	3
Long-term mepolizumab treatment reduces relapse rates in super-responders with eosinophilic granulomatosis with polyangiitis	3
X-linked SCID with a rare mutation	3
The effect of intra-nasal tetra sodium pyrophosphate on decreasing elevated nasal calcium and improving olfactory function post COVID-19: a randomized controlled trial	3
Tiotropium bromide as adjunct therapy in children with asthma: a clinical experience	3
Anaphylaxis after jellyfish ingestion with no history of stings: a pediatric case report	3
Anaphylaxis in a Swiss university emergency department: clinical characteristics and supposed triggers	3
A EUFOREA comment on a lost comorbidity of asthma	3
Reliability and validation of an electronic penicillin allergy risk-assessment tool in a pregnant population	3
Allergen bronchoprovocation: correlation between FEV1 maximal percent fall and area under the FEV1 curve and impact of allergen on recovery	3
Autoinflammatory gene mutations associated with eosinophilia and asthma	3
Aplastic anemia secondary to dual cancer immunotherapies a physician nightmare: case report and literature review	3
Pulmonary eosinophilia may indicate onset stage of allergic bronchopulmonary aspergillosis	3
Isotretinoin-associated exercise-induced anaphylaxis in a patient with birch pollinosis and soybean sensitization: case presentation and literature review	3
Novel pediatric granulomatosis with polyangiitis with a marked bloody pericardial effusion and bloody stool: a case report	3
Demographic characteristics associated with food allergy in a Nationwide Canadian Study	3
Severe distributive shock, neutrophilic dermatosis, and ST-elevation myocardial infarction in the setting of azathioprine hypersensitivity syndrome	3
Therapeutic effects of intranasal tocotrienol-rich fraction on rhinitis symptoms in platelet-activating factor induced allergic rhinitis	3
Rituximab and dupilumab improve eosinophilic granulomatosis with polyangiitis with multiple pulmonary thrombi	3
Canadian food ladders for dietary advancement in children with IgE-mediated allergy to milk and/or egg	3
Potential therapeutic approach of intravenous immunoglobulin against COVID-19	3
Clinical outcomes of dupilumab therapy in chronic rhinosinusitis with nasal polyps in a Canadian tertiary care rhinology practice	3
Cost-effectiveness of watchful waiting versus immediate emergency department transfer after epinephrine autoinjector use in Canada	3
Allergy-related outcomes and sleep-related disorders in adults: a cross-sectional study based on NHANES 2005–2006	3
Osimertinib tolerance in a patient with Stevens Johnson syndrome during osimertinib therapy after treatment with pembrolizumab	3
DRESS syndrome due to iodinated contrast media. A case report	3
Infantile atopic dermatitis and maternal-infant bonding: a mixed methods study	3
Safety and adherence of early oral immunotherapy for peanut allergy in a primary care setting: a retrospective cross-sectional study	2
Association between depression and mortality in persons with asthma: a population-based cohort study	2
A survey of severe asthma in Canada: results from the CASCADE practice reflective program	2
2022 CSACI annual scientific meeting book of abstracts	2
The association between allergy and sinusitis: a cross-sectional study based on NHANES 2005–2006	2
Inborn errors of immunity (primary immunodeficiencies)	2
A clinician’s guide for administration of high-concentration and facilitated subcutaneous immunoglobulin replacement therapy in patients with primary immunodeficiency diseases	2
COVID-19 vaccine testing & administration guidance for allergists/immunologists from the Canadian Society of Allergy and Clinical Immunology (CSACI)	2
Role of Th2, Th17 and Treg Cells and relevant cytokines in pathogenesis of allergic rhinitis	2
Delayed hypersensitivity reaction to cosmetic filler following two COVID-19 vaccinations and infection	2
Eight tips for the implementation of the first licenced peanut allergy oral immunotherapy into clinical practice	2
Systemic reactions to subcutaneous allergen immunotherapy: real-world cause and effect modelling	2
Infantile atopic dermatitis – increasing severity predicts negative impacts on maternal and infant sleep: a mixed methods study	2
Pediatric emergency department-based asthma education tools and parent/child asthma knowledge	2
Improvement of skin lesions in corticosteroid withdrawal-associated severe eczema by multicomponent traditional Chinese medicine therapy	2
Canadian Society of Allergy and Clinical Immunology position statement: panel testing for food allergies	2
“Vegan” and “plant-based” claims: risk implications for milk- and egg-allergic consumers in Canada	2
Focused allergic rhinitis practice parameter for Canada	2
Exercise induced anaphylaxis in kiwi allergic patient: case report	2
Asthma occurrence in children and early life systemic antibiotic use: an incidence density study	2
Gene–gene and gene-environment interactions on cord blood total IgE in Chinese Han children	2
Long term longitudinal follow-up of an AD-HIES cohort: the impact of early diagnosis and enrollment to IPINet centers on the natural history of Job’s syndrome	2
Helicobacter pylori infection attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in C57/BL6 mice	2
Introduction from the editors	2
Cost-effectiveness analysis of biologics for the treatment of chronic rhinosinusitis with nasal polyps in Canada	2
Turning walking pneumonia into recurrent abscesses: a curious case of CVID and review of the literature	2
Maternal smoking during infancy increases the risk of allergic diseases in children: a nationwide longitudinal survey in Japan	2
Drug-induced hypersensitivity syndrome induced by propylthiouracil: case report and literature review	2
PRevalence of the Eosinophilic Phenotype Among SeveRE asthma patients in Lebanon: results of the PREPARE study	2
Immunoglobulin replacement therapy in patients with primary and secondary immunodeficiencies: impact of infusion method on immunoglobulin-specific perceptions of quality of life and treatment satisfac	2
Biphasic anaphylaxis in a Canadian tertiary care centre: an evaluation of incidence and risk factors from electronic health records and telephone interviews	2
Clinical validation of controlled exposure to house dust mite in the environmental exposure unit (EEU)	2
The impact of CFTR modulator triple therapy on type 2 inflammatory response in patients with cystic fibrosis	2
Atopic dermatitis and risk of autoimmune diseases: a systematic review and meta-analysis	2
Successful treatment of refractory status asthmaticus with omalizumab: a case report	2
Trained immunity induced by in vivo peptide-based STAT6 inhibition prevents ragweed allergy in mice	2
Eosinophil-independent IL-5 levels are increased in critically ill COVID-19 patients who survive	2
Food oral immunotherapy	2
Diagnostic validity of specific immunoglobulin E levels to alpha-gal in alpha-gal syndrome: a cross-sectional analysis	2
Anti-asthmatic miR-224-5p inhibits the FHL1/MAPK pathway to repress airway smooth muscle cell proliferation in a murine model of asthma-like airway inflammation	2
Management of a patient with common variable immunodeficiency and hepatopathy	2
Fatal eosinophilic myocarditis and submassive hepatic necrosis in lamotrigine induced DRESS syndrome	2
Prevalence of reported food allergies in Brazilian preschoolers living in a small Brazilian city	2
Long-term efficacy of HDM-SCIT in pediatric and adult patients with allergic rhinitis	2