Clinical & Translational Oncology

Article	Citations
The new function of circRNA: translation	108
Covid-19 transmission, outcome and associated risk factors in cancer patients at the first month of the pandemic in a Spanish hospital in Madrid	71
Multidisciplinary practice guidelines for the diagnosis, genetic counseling and treatment of pheochromocytomas and paragangliomas	67
Drug-metabolizing enzymes: role in drug resistance in cancer	59
A signature of 14 immune-related gene pairs predicts overall survival in gastric cancer	41
CDK1 promotes the stemness of lung cancer cells through interacting with Sox2	40
Exosome-transmitted lncRNA PCGEM1 promotes invasive and metastasis in gastric cancer by maintaining the stability of SNAI1	40
SEOM clinical guidelines for the treatment of head and neck cancer (2020)	37
Ferroptosis: an iron-dependent cell death form linking metabolism, diseases, immune cell and targeted therapy	37
Immune cell infiltration features and related marker genes in lung cancer based on single-cell RNA-seq	33
Inhibitory effect of polyphenols (phenolic acids, lignans, and stilbenes) on cancer by regulating signal transduction pathways: a review	32
Comprehensive assessment of multiple tryptophan metabolites as potential biomarkers for immune checkpoint inhibitors in patients with non-small cell lung cancer	31
Cyclin-dependent kinase (CDK) inhibitors in solid tumors: a review of clinical trials	30
Neutrophil-to-lymphocyte ratio and lactate dehydrogenase as biomarkers for urothelial cancer treated with immunotherapy	29
Anti-PD-1/L1-associated immune-related adverse events as harbinger of favorable clinical outcome: systematic review and meta-analysis	29
A natural flavonoid, apigenin isolated from Clerodendrum viscosum leaves, induces G2/M phase cell cycle arrest and apoptosis in MCF-7 cells through the regulation of p53 and caspase-cascade pathway	28
Tumor microenvironment in triple-negative breast cancer: the correlation of tumor-associated macrophages and tumor-infiltrating lymphocytes	28
Traditional Chinese medicine reverses cancer multidrug resistance and its mechanism	27
Apolipoproteins, as the carrier proteins for lipids, are involved in the development of breast cancer	27
Prognostic impact of Claudin 18.2 in gastric and esophageal adenocarcinomas	27
The emerging roles of exosomal circRNAs in diseases	26
Curcumin suppresses tumor growth of gemcitabine-resistant non-small cell lung cancer by regulating lncRNA-MEG3 and PTEN signaling	25
Targeting GLS1 to cancer therapy through glutamine metabolism	25
CDKN2A inhibits cell proliferation and invasion in cervical cancer through LDHA-mediated AKT/mTOR pathway	25
Multidisciplinary consensus statement on the clinical management of patients with pancreatic cancer	24

SEOM Clinical Guideline of management of soft-tissue sarcoma (2020)	24
Tumor microenvironment, immune response and post-radiotherapy tumor clearance	24
Renin-angiotensin system and cancer: epidemiology, cell signaling, genetics and epigenetics	24
Programmable and multi-targeted CARs: a new breakthrough in cancer CAR-T cell therapy	23
Urinary microRNAs expression in prostate cancer diagnosis: a systematic review	23
miR-143-3p inhibits proliferation and invasion of hepatocellular carcinoma cells by regulating its target gene FGF1	22
SEOM clinical guideline in ovarian cancer (2020)	22
SEOM clinical guidelines for pancreatic and biliary tract cancer (2020)	22
Complex roles of discoidin domain receptor tyrosine kinases in cancer	22
SEOM clinical guideline for the management of cutaneous melanoma (2020)	21
MiR-495-3p and miR-143-3p co-target CDK1 to inhibit the development of cervical cancer	21
Hyperbaric oxygen and radiation therapy: a review	21
ST8SIA1 inhibition sensitizes triple negative breast cancer to chemotherapy via suppressing Wnt/β-catenin and FAK/Akt/mTOR	20
Social support, coping strategies and sociodemographic factors in women with breast cancer	20
Consensus of experts from the Spanish Pharmacogenetics and Pharmacogenomics Society and the Spanish Society of Medical Oncology for the genotyping of DPYD in cancer patients who are candidates for tre	19
FAM83H overexpression predicts worse prognosis and correlates with less CD8+ T cells infiltration and Ras-PI3K-Akt-mTOR signaling pathway in pancreatic cancer	19
miR-22 suppresses cell viability and EMT of ovarian cancer cells via NLRP3 and inhibits PI3K/AKT signaling pathway	19
RUNX1-activated upregulation of lncRNA RNCR3 promotes cell proliferation, invasion, and suppresses apoptosis in colorectal cancer via miR-1301-3p/AKT1 axis in vitro and in vivo	19
ADMA mediates gastric cancer cell migration and invasion via Wnt/β-catenin signaling pathway	19
Research progress of tumor microenvironment and tumor-associated macrophages	18
SEOM clinical guidelines for the treatment of advanced prostate cancer (2020)	18
hsa_circ_0121582 inhibits leukemia growth by dampening Wnt/β-catenin signaling	18
A comprehensive overview on the molecular biology of human glioma: what the clinician needs to know	18
The role of macrophages during breast cancer development and response to chemotherapy	17
ABVD and BEACOPP regimens’ effects on fertility in young males with Hodgkin lymphoma	17
Randomized placebo-controlled phase II trial of high-dose melatonin mucoadhesive oral gel for the prevention and treatment of oral mucositis in patients with head and neck cancer undergoing radiation	17
Incidence of venous thromboembolic events in cancer patients receiving immunotherapy: a single-institution experience	17
The effects of human sera conditioned by high-intensity exercise sessions and training on the tumorigenic potential of cancer cells	16
The correlation of 18F-FDG PET/CT metabolic parameters, clinicopathological factors, and prognosis in breast cancer	16
Oligo metastatic renal cell carcinoma: stereotactic body radiation therapy, if, when and how?	15
Clinical significance of expression level of CX3CL1–CX3CR1 axis in bone metastasis of lung cancer	15
Multidisciplinary consensus on the criteria for fertility preservation in cancer patients	15
Novel combinatorial strategies for boosting the efficacy of immune checkpoint inhibitors in advanced breast cancers	15
Clinicopathological and prognostic value of hypoxia-inducible factor-1α in breast cancer: a meta-analysis including 5177 patients	15
Multidisciplinary consensus on optimising the detection of NTRK gene alterations in tumours	15
Current updates on the role of reactive oxygen species in bladder cancer pathogenesis and therapeutics	15
SEOM clinical guidelines for the treatment of malignant pleural mesothelioma (2020)	15
PSMA-PET and micro-ultrasound potential in the diagnostic pathway of prostate cancer	15
Trends of incidence, mortality and survival of multiple myeloma in Spain. A twenty-three-year population-based study	15
Circ_03955 promotes pancreatic cancer tumorigenesis and Warburg effect by targeting the miR-3662/HIF-1α axis	15
Identification of a novel cancer microbiome signature for predicting prognosis of human breast cancer patients	14
Cytomegalovirus infection as an underestimated trigger for checkpoint inhibitor-related pneumonitis in lung cancer: a retrospective study	14
Circular RNAs as important players in human gastric cancer	14
Stereotactic ablative radiotherapy in castration-resistant prostate cancer patients with oligoprogression during androgen receptor-targeted therapy	14
PILE: a candidate prognostic score in cancer patients treated with immunotherapy	14
Multidisciplinary consensus on cancer management during pregnancy	14
MiR-92 overexpression suppresses immune cell function in ovarian cancer via LATS2/YAP1/PD-L1 pathway	14
PRDX2 plays an oncogenic role in esophageal squamous cell carcinoma via Wnt/β-catenin and AKT pathways	14
A seven-nuclear receptor-based prognostic signature in breast cancer	14
Propofol inhibited gastric cancer proliferation via the hsa-miR-328-3p/STAT3 pathway	14

Oxymatrine reduces expression of programmed death-ligand 1 by promoting DNA demethylation in colorectal cancer cells	14
Human umbilical cord mesenchymal stem cell-derived exosomes carrying hsa-miRNA-128-3p suppress pancreatic ductal cell carcinoma by inhibiting Galectin-3	13
Evaluating anti-tumor activity of palbociclib plus radiation in anaplastic and radiation-induced meningiomas: pre-clinical investigations	13
UCHL3 promotes aerobic glycolysis of pancreatic cancer through upregulating LDHA expression	13
Nerve growth factor orchestrates NGAL and matrix metalloproteinases activity to promote colorectal cancer metastasis	13
Role of adjuvant radiotherapy in atypical (WHO grade II) and anaplastic (WHO grade III) meningiomas: a systematic review	13
PARP inhibitor niraparib as a radiosensitizer promotes antitumor immunity of radiotherapy in EGFR-mutated non-small cell lung cancer	13
miR-144-3p increases radiosensibility of gastric cancer cells by targeting inhibition of ZEB1	13
Cellular immunotherapy: a clinical state-of-the-art of a new paradigm for cancer treatment	13
DDAB cationic lipid-mPEG, PCL copolymer hybrid nano-carrier synthesis and application for delivery of siRNA targeting IGF-1R into breast cancer cells	13
The role of brachytherapy (interventional radiotherapy) for primary and/or recurrent vulvar cancer: a Gemelli Vul.Can multidisciplinary team systematic review	13
Influence of glioblastoma contact with the subventricular zone on survival and recurrence patterns	13
Survival outcomes and prognostic factors of endometrial stromal sarcoma and undifferentiated uterine sarcoma	13
Update of the recommendations for the determination of biomarkers in colorectal carcinoma: National Consensus of the Spanish Society of Medical Oncology and the Spanish Society of Pathology	13
Identification of a novel immune prognostic model in gastric cancer	12
Physio-pathological effects of m6A modification and its potential contribution to melanoma	12
Circular RNA circHIPK3 modulates prostate cancer progression via targeting miR-448/MTDH signaling	12
Role of the parasympathetic nervous system in cancer initiation and progression	12
Dynamic biomarkers indicate the immunological benefits provided by Ganoderma spore powder in post-operative breast and lung cancer patients	12
Radiation-induced lymphopenia: the main aspects to consider in immunotherapy trials for endometrial and cervical cancer patients	12
LncRNA DCST1-AS1 downregulates miR-29b through methylation in glioblastoma (GBM) to promote cancer cell proliferation	12
Dynamics of clinical biomarkers as predictors of immunotherapy benefit in metastatic melanoma patients	12
IFN-γ inhibits ovarian cancer progression via SOCS1/JAK/STAT signaling pathway	12
TWIST1 upregulation affects E-cadherin expression in brain metastases	12
Microbiota and cancer: current understanding and mechanistic implications	11
Blockage of PAK1 alleviates the proliferation and invasion of NSCLC cells via inhibiting ERK and AKT signaling activity	11
Predictive and prognostic value of total tumor load in sentinel lymph nodes in breast cancer patients after neoadjuvant treatment using one-step nucleic acid amplification: the NEOVATTL study	11
Study on effects of miR-141-3p in proliferation, migration, invasion and apoptosis of colon cancer cells by inhibiting Bcl2	11
Paeonol inhibits proliferation and induces cell apoptosis of human T24 and 5637 bladder cancer cells in vitro and in vivo	11
The TRIM proteins in cancer: from expression to emerging regulatory mechanisms	11
SEOM clinical guidelines for anaemia treatment in cancer patients (2020)	11
The effect of PD-1 expression on tumor-associated macrophage in T cell lymphoma	11
Long-term outcomes of induction chemotherapy followed by chemoradiotherapy vs chemoradiotherapy alone as treatment of unresectable head and neck cancer: follow-up of the Spanish Head and Neck Cancer G	11
MGMT-inhibitor in combination with TGF-βRI inhibitor or CDK 4/6 inhibitor increases temozolomide sensitivity in temozolomide-resistant glioblastoma cells	10
Long-term disease outcome and volume-based decision strategy in a large cohort of multiple brain metastases treated with a mono-isocentric linac-based Stereotactic Radiosurgery technique	10
Is there a role for chemotherapy and radiation in the treatment of patients with low-grade myofibroblastic sarcoma?	10
Cytotoxic T lymphocyte antigen-4 (CTLA-4) expression in chordoma and tumor-infiltrating lymphocytes (TILs) predicts prognosis of spinal chordoma	10
Evaluation of color Doppler ultrasound combined with plasma miR-21 and miR-27a in the diagnosis of breast cancer	10
High expression level of interleukin-1β is correlated with poor prognosis and PD-1 expression in patients with lung adenocarcinoma	10
Prognostic value of neutrophil-to-lymphocyte ratio in advanced cancer patients receiving immunotherapy	10
Surface-guided radiation therapy for breast cancer: more precise positioning	10
Identifying a novel 5-gene signature predicting clinical outcomes in acute myeloid leukemia	10
Systematic review and meta-analysis efficacy and safety of immune checkpoint inhibitors in advanced melanoma patients with anti-PD-1 progression: a systematic review and meta-analysis	10
COL4A1, negatively regulated by XPD and miR-29a-3p, promotes cell proliferation, migration, invasion and epithelial–mesenchymal transition in liver cancer cells	10
Tumor immune microenvironment is influenced by frameshift mutations and tumor mutational burden in gastric cancer	10
Prognostic value of neutrophil-to-lymphocyte ratio and other inflammatory markers in patients with high-risk soft tissue sarcomas	10
Maintenance treatment in advanced HER2-negative gastric cancer	10
Challenges in early phase clinical trials for childhood cancer during the COVID-19 pandemic: a report from the new agents group of the Spanish Society of Paediatric Haematology and Oncology (SEHOP)	10
Clinical nutrition as part of the treatment pathway of pancreatic cancer patients: an expert consensus	10
microRNA-377-3p inhibits osteosarcoma progression by targeting CUL1 and regulating Wnt/β-catenin signaling pathway	10
Cancer cell-intrinsic STING is associated with CD8 + T-cell infiltration and might serve as a potential immunotherapeutic target in hepatocellular carcinoma	9
The impact of surgical margin status on prostate cancer-specific mortality after radical prostatectomy: a systematic review and meta-analysis	9
Over-activation of EFTUD2 correlates with tumor propagation and poor survival outcomes in hepatocellular carcinoma	9
Clinical activity of brigatinib in ROS1-rearranged non-small cell lung cancer	9
GEIS-SEHOP clinical practice guidelines for the treatment of rhabdomyosarcoma	9
Study of the Spanish Society of Medical Oncology (SEOM) on the access to oncology drugs and predictive biomarkers in Spain	9
CIP2A silencing alleviates doxorubicin resistance in MCF7/ADR cells through activating PP2A and autophagy	9
Breast cancer, placing drug interactions in the spotlight: is polypharmacy the cause of everything?	9
Potential biomarkers for early detection of pancreatic ductal adenocarcinoma	9
Upfront pembrolizumab as an effective treatment start in patients with PD-L1 ≥ 50% non-oncogene addicted non-small cell lung cancer and asymptomatic brain metastases: an exploratory analysis	9
Chemo-radiotherapy integration in unresectable locally advanced non-small-cell lung cancer: a review	9
Peripheral blood T-cell receptor repertoire as a predictor of clinical outcomes in gastrointestinal cancer patients treated with PD-1 inhibitor	9
Surgery versus stereotactic body radiotherapy for clinical stage I non-small-cell lung cancer: propensity score-matching analysis including the ratio of ground glass nodules	9
Effect of Gemcitabine based chemotherapy on the immunogenicity of pancreatic tumour cells and T-cells	9
ECO-SEOM-SEEO safety recommendations guideline for cancer patients receiving intravenous therapy	8
Long-term results of a randomized partial irradiation trial compared to whole breast irradiation in the early stage and low-risk breast cancer patients after conservative surgery	8
Detection rate, pattern of relapse and influence on therapeutic decision of PSMA PET/CT in patients affected by biochemical recurrence after radical prostatectomy, a retrospective case series	8
Radiotherapy in adult low-grade glioma: nationwide trends in treatment and outcomes	8
Exosome-mediated delivery of SCD-1 siRNA promoted the death of anaplastic thyroid carcinoma cells via regulating ROS level	8
Incidence of venous thromboembolism in patients with colorectal cancer according to oncogenic status	8
Impact of adjuvant therapy toxicity on quality of life and emotional symptoms in patients with colon cancer: a latent class analysis	8
Low-dose radiation therapy: could it be a game-changer for COVID-19?	8
Serum CXCL13 and PECAM-1 can be used as diagnostic and prognostic markers in elderly patients with gastric cancer	8
Challenges in the treatment of breast cancer brain metastases: evidence, unresolved questions, and a practical algorithm	8
Combination therapy with TiO2 nanoparticles and cisplatin enhances chemotherapy response in murine melanoma models	8
100% peer review in radiation oncology: is it feasible?	8
CLIC1 knockout inhibits invasion and migration of gastric cancer by upregulating AMOT-p130 expression	8
Expression levels of SCCA and CYFRA 21-1 in serum of patients with laryngeal squamous cell carcinoma and their correlation with tumorigenesis and progression	8
5-year results of accelerated partial breast irradiation (APBI) with SBRT (stereotactic body radiation therapy) and exactrac adaptive gating (Novalis®) for very early breast cancer patients: was it al	8
Circulating exosomal miRNAs and cancer early diagnosis	8

Sarcoidosis-like reactions in cancer patients treated with immune checkpoint inhibitors: experience in a Spanish hospital	8
Stereotactic body radiation therapy for liver metastasis from colorectal cancer: size matters	8
In-depth characterization of a new patient-derived xenograft model for metaplastic breast carcinoma to identify viable biologic targets and patterns of matrix evolution within rare tumor types	8
Medical ozone induces proliferation and migration inhibition through ROS accumulation and PI3K/AKT/NF-κB suppression in human liver cancer cells in vitro	8
Sexual, bladder and bowel function following different minimally invasive techniques of radical hysterectomy in patients with early-stage cervical cancer	8
The peri- and intratumoral immune cell infiltrate and PD-L1 status in invasive squamous cell carcinomas of the penis	7
Clinical outcomes of FOLFIRINOX and gemcitabine–nab paclitaxel for metastatic pancreatic cancer in the real world setting	7
Surgical resection of primary tumor in the extremities improves survival for metastatic soft-tissue sarcoma patients: a population-based study of the SEER database	7
The role of radiotherapy for pancreatic malignancies: a population-based analysis of the SEER database	7
Expression-based, consistent biomarkers for prognosis and diagnosis in lung cancer	7
Investigation on potential biomarkers of hyperprogressive disease (HPD) triggered by immune checkpoint inhibitors (ICIs)	7
Clinical and molecular characteristics of epidermal growth factor receptor exon 20 insertion mutations in non-small-cell lung cancer	7
The effect of metformin on esophageal cancer risk in patients with type 2 diabetes mellitus: a systematic review and meta‑analysis	7
Clinical significance of multi-slice spiral CT, MRI combined with gastric contrast-enhanced ultrasonography in the diagnosis of T staging of gastric cancer	7
Expression and DNA methylation profiles of EZH2-target genes in plasma exosomes and matched primary tumor tissues of the patients with diffuse large B-cell lymphoma	7
Adrenal cancer: relevance of different grading systems and subtypes	7
Comprehensive study for BRCA1 and BRCA2 entire coding regions in breast cancer	7
Exclusive 3D-brachytherapy as a good option for stage-I inoperable endometrial cancer: a retrospective analysis in the gynaecological cancer GEC-ESTRO Working Group	7
A three-gene signature and clinical outcome in pediatric acute myeloid leukemia	7
A new biological triangle in cancer: intestinal microbiota, immune checkpoint inhibitors and antibiotics	7
Impact of miRNAs expression modulation on the methylation status of breast cancer stem cell-related genes	7
A systematic review of craniospinal irradiation for leptomeningeal disease: past, present, and future	7
Association of TYRP1 with hypoxia and its correlation with patient outcome in uveal melanoma	7
Overall survival for early and locally advanced non-small-cell lung cancer from one institution: 2000–2017	7
Prognostic value of neutrophil–lymphocyte ratio in critically ill patients with cancer: a propensity score matching study	7
Brain metastases treated with radiosurgery or hypofractionated stereotactic radiotherapy: outcomes and predictors of survival	7
Expressions of PD-L1 and Nectin-4 in urothelial cancer patients treated with pembrolizumab	6
Correlation between the contrast-enhanced ultrasound image features and axillary lymph node metastasis of primary breast cancer and its diagnostic value	6
Comparative genomic characterization of melanoma of known and unknown primary	6
Antibody–drug conjugate as targeted therapeutics against hepatocellular carcinoma: preclinical studies and clinical relevance	6
A multidisciplinary consensus on the morphological and functional responses to immunotherapy treatment	6
CDC6 is up-regulated and a poor prognostic signature in glioblastoma multiforme	6
Downregulation of HOXA11 enhances endometrial cancer malignancy and cisplatin resistance via activating PTEN/AKT signaling pathway	6
PD-1 and PD-L1 gene expressions and their association with Epstein-Barr virus infection in chronic lymphocytic leukemia	6
Irinotecan and temozolomide chemotherapy in paediatric and adult populations with relapsed Ewing Sarcoma	6
Biological functions and potential therapeutic applications of huntingtin-associated protein 1: progress and prospects	6
Reduce proliferation of human bone marrow cells from acute myeloblastic leukemia with minimally differentiation by blocking lncRNA PVT1	6
Alterations in regulatory T cells and immune checkpoint molecules in pancreatic cancer patients receiving FOLFIRINOX or gemcitabine plus nab-paclitaxel	6
Long intergenic non-coding RNA-p21 is associated with poor prognosis in chronic lymphocytic leukemia	6
Mechanisms of primary and acquired resistance to PD-1/PD-L1 blockade and the emerging role of gut microbiome	6
HPV16 infection promotes an M2 macrophage phenotype to promote the invasion and metastasis of esophageal squamous cell carcinoma	6
Quality indicators and excellence requirements for a multidisciplinary lung cancer tumor board by the Spanish Lung Cancer Group	6
Magnetic resonance imaging evaluation of brain glioma before postoperative radiotherapy	6
Senescent thyroid tumor cells promote their migration by inducing the polarization of M2-like macrophages	6
The application value of PAX1 and ZNF582 gene methylation in high grade intraepithelial lesion and cervical cancer	6
Efficacy of nintedanib plus docetaxel in patients with refractory advanced epidermal growth factor receptor mutant lung adenocarcinoma	6
SEOM clinical guideline for management of adult medulloblastoma (2020)	6