Protein & Cell

(The TQCC of Protein & Cell is 24. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-06-01 to 2023-06-01.)
Functional metabolomics: from biomarker discovery to metabolome reprogramming203
Carboxylesterases in lipid metabolism: from mouse to human144
Effect of pH, temperature and freezing-thawing on quantity changes and cellular uptake of exosomes135
A structural view of the antibiotic degradation enzyme NDM-1 from a superbug123
Phage display screening of therapeutic peptide for cancer targeting and therapy116
Immune modulatory function of abundant immune-related microRNAs in microvesicles from bovine colostrum109
The microbiome in inflammatory bowel diseases: from pathogenesis to therapy92
New paradigms on hematopoietic stem cell differentiation90
Sialylation is involved in cell fate decision during development, reprogramming and cancer progression76
Developing potent PROTACs tools for selective degradation of HDAC6 protein74
Chemical screen identifies a geroprotective role of quercetin in premature aging71
Mesenchymal stem cell therapy for acute respiratory distress syndrome: from basic to clinics70
PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation67
Solution structure of the RNA recognition domain of METTL3-METTL14 N6-methyladenosine methyltransferase66
Crystal structure of cytotoxin protein suilysin from Streptococcus suis66
Release and uptake mechanisms of vesicular Ca2+ stores65
Crystal structures of d-psicose 3-epimerase from Clostridium cellulolyticum H10 and its complex with ketohexose sugars58
Tongue coating microbiome as a potential biomarker for gastritis including precancerous cascade54
Cryo-EM structure of an early precursor of large ribosomal subunit reveals a half-assembled intermediate53
Liberation of SARS-CoV main protease from the viral polyprotein: N-terminal autocleavage does not depend on the mature dimerization mode52
Chimeric antigen receptor T (CAR-T) cells expanded with IL-7/IL-15 mediate superior antitumor effects51
JMJD3 in the regulation of human diseases46
Cells derived from iPSC can be immunogenic — Yes or No?42
Modeling neuropsychiatric disorders using human induced pluripotent stem cells41
Functions of p53 in pluripotent stem cells39
Binding to m6A RNA promotes YTHDF2-mediated phase separation37
Rescue of premature aging defects in Cockayne syndrome stem cells by CRISPR/Cas9-mediated gene correction36
Phenotypic Tfh development promoted by CXCR5-controlled re-localization and IL-6 from radiation-resistant cells34
RNA binding protein 24 deletion disrupts global alternative splicing and causes dilated cardiomyopathy34
Down-regulation of the let-7i facilitates gastric cancer invasion and metastasis by targeting COL1A134
A peep into mitochondrial disorder: multifaceted from mitochondrial DNA mutations to nuclear gene modulation31
Mitochondrion-processed TERC regulates senescence without affecting telomerase activities31
Hepatitis B virus is degraded by autophagosome-lysosome fusion mediated by Rab7 and related components30
Transcriptional mechanism of IRF8 and PU.1 governs microglial activation in neurodegenerative condition30
Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells30
Remodeling of host membranes during herpesvirus assembly and egress29
Proteome-wide prediction of protein-protein interactions from high-throughput data29
Inhibition of Rac1-dependent forgetting alleviates memory deficits in animal models of Alzheimer’s disease29
Essential residues for the enzyme activity of ATP-dependent MurE ligase from Mycobacterium tuberculosis28
Structures of SdrD from Staphylococcus aureus reveal the molecular mechanism of how the cell surface receptors recognize their ligands28
Glutathione regulates the transfer of iron-sulfur cluster from monothiol and dithiol glutaredoxins to apo ferredoxin28
Low-dose quercetin positively regulates mouse healthspan28
Re-detectable positive SARS-CoV-2 RNA tests in patients who recovered from COVID-19 with intestinal infection27
An unexpected similarity between antibiotic-resistant NDM-1 and beta-lactamase II from Erythrobacter litoralis27
Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis26
Long non-coding RNA LncKdm2b regulates cortical neuronal differentiation by cis-activating Kdm2b26
Analysis of VISTA expression and function in renal cell carcinoma highlights VISTA as a potential target for immunotherapy26
Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion26
Basic and translational aging research in China: present and future26
DNMT3A reads and connects histone H3K36me2 to DNA methylation25
TMEM43-S358L mutation enhances NF-κB-TGFβ signal cascade in arrhythmogenic right ventricular dysplasia/cardiomyopathy25
An octamer of enolase from Streptococcus suis24
Lipid droplets and mitochondria are anchored during brown adipocyte differentiation24
Molecular basis for the inhibition of β-hydroxyacyl-ACP dehydratase HadAB complex from Mycobacterium tuberculosis by flavonoid inhibitors24