OOIR: Observatory of International Research

Papers

(The TQCC of Protein & Cell is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Ferroptosis, radiotherapy, and combination therapeutic strategies	231
The role of the gut microbiome and its metabolites in metabolic diseases	224
Targeting the alternative bile acid synthetic pathway for metabolic diseases	183
Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332	137
Unexpected guests in the tumor microenvironment: microbiome in cancer	132
High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors	109
The potential of using blood circular RNA as liquid biopsy biomarker for human diseases	97
Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos	95
RIP1-dependent linear and nonlinear recruitments of caspase-8 and RIP3 respectively to necrosome specify distinct cell death outcomes	89
Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model	78
The mini player with diverse functions: extracellular vesicles in cell biology, disease, and therapeutics	70
Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling	69
Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection	69
Single-nucleus transcriptomic landscape of primate hippocampal aging	58
Lipids and membrane-associated proteins in autophagy	52
Cytochrome P450 reductase (POR) as a ferroptosis fuel	49
Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis	38
PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis	37
A pair of transporters controls mitochondrial Zn2+ levels to maintain mitochondrial homeostasis	36
The microbiota–gut–brain axis and neurodevelopmental disorders	36
The best practice for microbiome analysis using R	34
Nuclear cGAS: sequestration and beyond	33
Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2	33
Pan-coronavirus fusion inhibitors as the hope for today and tomorrow	31
Higher-order assemblies in immune signaling: supramolecular complexes and phase separation	31

The p21-activated kinases in neural cytoskeletal remodeling and related neurological disorders	29
3D chromatin architecture and epigenetic regulation in cancer stem cells	27
An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope	27
Structural insights into the activation initiation of full-length mGlu1	25
Single cell RNA and immune repertoire profiling of COVID-19 patients reveal novel neutralizing antibody	25
Precise genome editing without exogenous donor DNA via retron editing system in human cells	24
cGAS guards against chromosome end-to-end fusions during mitosis and facilitates replicative senescence	22
METTL14 is a chromatin regulator independent of its RNA N 6-methyladenosine methyltransferase activity	22
Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids	22
Cancer biology deciphered by single-cell transcriptomic sequencing	22
The exploration of N6-deoxyadenosine methylation in mammalian genomes	21
METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth	20
Structural basis of INTAC-regulated transcription	19
Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization	17
Single-cell RNA-Seq analysis identified kidney progenitor cells from human urine	17
Sinoatrial node pacemaker cells share dominant biological properties with glutamatergic neurons	17
Recent progress and challenges in the treatment of spinal cord injury	16
Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon	16
Microbiome research outlook: past, present, and future	16
Repurposing FDA-approved drugs for SARS-CoV-2 through an ELISA-based screening for the inhibition of RBD/ACE2 interaction	16
Indiscriminate ssDNA cleavage activity of CRISPR-Cas12a induces no detectable off-target effects in mouse embryos	14
Impact of the microbiome on mosquito-borne diseases	14
Maternal heterozygous mutation in CHEK1 leads to mitotic arrest in human zygotes	13
The ubiquitin codes in cellular stress responses	13
A single-nucleus transcriptomic atlas of primate testicular aging reveals exhaustion of the spermatogonial stem cell reservoir and loss of Sertoli cell homeostasis	13
Convergent evolution of SARS-CoV-2 in human and animals	13
Roles of Tet2 in meiosis, fertility and reproductive aging	12
A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes	12
CRISPR-assisted transcription activation by phase-separation proteins	12
The two-stage interaction of Ebola virus VP40 with nucleoprotein results in a switch from viral RNA synthesis to virion assembly/budding	11
Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis	11
RNA m6A meets transposable elements and chromatin	11
Microbial sensing in the intestine	11
A YAP/TAZ-CD54 axis is required for CXCR2 −CD44 − tumor-specific neutrophils to suppress gastric cancer	11
APOE-mediated suppression of the lncRNA MEG3 protects human cardiovascular cells from chronic inflammation	10
Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond	10
Molecular deconvolution of the neutralizing antibodies induced by an inactivated SARS-CoV-2 virus vaccine	10
ORP8 acts as a lipophagy receptor to mediate lipid droplet turnover	10
Single-cell transcriptomic Atlas of mouse cochlear aging	10
Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging	9
Restoration of FMRP expression in adult V1 neurons rescues visual deficits in a mouse model of fragile X syndrome	9
mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells	9
BMP7 expression in mammalian cortical radial glial cells increases the length of the neurogenic period	9