OOIR: Observatory of International Research

Papers

(The median citation count of Protein & Cell is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Ferroptosis, radiotherapy, and combination therapeutic strategies	231
The role of the gut microbiome and its metabolites in metabolic diseases	224
Targeting the alternative bile acid synthetic pathway for metabolic diseases	183
Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332	137
Unexpected guests in the tumor microenvironment: microbiome in cancer	132
High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors	109
The potential of using blood circular RNA as liquid biopsy biomarker for human diseases	97
Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos	95
RIP1-dependent linear and nonlinear recruitments of caspase-8 and RIP3 respectively to necrosome specify distinct cell death outcomes	89
Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model	78
The mini player with diverse functions: extracellular vesicles in cell biology, disease, and therapeutics	70
Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection	69
Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling	69
Single-nucleus transcriptomic landscape of primate hippocampal aging	58
Lipids and membrane-associated proteins in autophagy	52
Cytochrome P450 reductase (POR) as a ferroptosis fuel	49
Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis	38
PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis	37
The microbiota–gut–brain axis and neurodevelopmental disorders	36
A pair of transporters controls mitochondrial Zn2+ levels to maintain mitochondrial homeostasis	36
The best practice for microbiome analysis using R	34
Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2	33
Nuclear cGAS: sequestration and beyond	33
Pan-coronavirus fusion inhibitors as the hope for today and tomorrow	31
Higher-order assemblies in immune signaling: supramolecular complexes and phase separation	31

The p21-activated kinases in neural cytoskeletal remodeling and related neurological disorders	29
3D chromatin architecture and epigenetic regulation in cancer stem cells	27
An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope	27
Single cell RNA and immune repertoire profiling of COVID-19 patients reveal novel neutralizing antibody	25
Structural insights into the activation initiation of full-length mGlu1	25
Precise genome editing without exogenous donor DNA via retron editing system in human cells	24
Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids	22
Cancer biology deciphered by single-cell transcriptomic sequencing	22
cGAS guards against chromosome end-to-end fusions during mitosis and facilitates replicative senescence	22
METTL14 is a chromatin regulator independent of its RNA N 6-methyladenosine methyltransferase activity	22
The exploration of N6-deoxyadenosine methylation in mammalian genomes	21
METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth	20
Structural basis of INTAC-regulated transcription	19
Sinoatrial node pacemaker cells share dominant biological properties with glutamatergic neurons	17
Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization	17
Single-cell RNA-Seq analysis identified kidney progenitor cells from human urine	17
Repurposing FDA-approved drugs for SARS-CoV-2 through an ELISA-based screening for the inhibition of RBD/ACE2 interaction	16
Recent progress and challenges in the treatment of spinal cord injury	16
Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon	16
Microbiome research outlook: past, present, and future	16
Impact of the microbiome on mosquito-borne diseases	14
Indiscriminate ssDNA cleavage activity of CRISPR-Cas12a induces no detectable off-target effects in mouse embryos	14
Convergent evolution of SARS-CoV-2 in human and animals	13
Maternal heterozygous mutation in CHEK1 leads to mitotic arrest in human zygotes	13
The ubiquitin codes in cellular stress responses	13
A single-nucleus transcriptomic atlas of primate testicular aging reveals exhaustion of the spermatogonial stem cell reservoir and loss of Sertoli cell homeostasis	13
A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes	12
CRISPR-assisted transcription activation by phase-separation proteins	12
Roles of Tet2 in meiosis, fertility and reproductive aging	12
Microbial sensing in the intestine	11
A YAP/TAZ-CD54 axis is required for CXCR2 −CD44 − tumor-specific neutrophils to suppress gastric cancer	11
The two-stage interaction of Ebola virus VP40 with nucleoprotein results in a switch from viral RNA synthesis to virion assembly/budding	11
Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis	11
RNA m6A meets transposable elements and chromatin	11
ORP8 acts as a lipophagy receptor to mediate lipid droplet turnover	10
Single-cell transcriptomic Atlas of mouse cochlear aging	10
APOE-mediated suppression of the lncRNA MEG3 protects human cardiovascular cells from chronic inflammation	10
Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond	10
Molecular deconvolution of the neutralizing antibodies induced by an inactivated SARS-CoV-2 virus vaccine	10
BMP7 expression in mammalian cortical radial glial cells increases the length of the neurogenic period	9
Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging	9
Restoration of FMRP expression in adult V1 neurons rescues visual deficits in a mouse model of fragile X syndrome	9
mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells	9
“Sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interaction	8
OSMRβ mutants enhance basal keratinocyte differentiation via inactivation of the STAT5/KLF7 axis in PLCA patients	8
Enhancing Prime Editing Efficiency and Flexibility with Tethered and Split pegRNAs	8
Persisting lung pathogenesis and minimum residual virus in hamster after acute COVID-19	8
Nutri-microbiome epidemiology, an emerging field to disentangle the interplay between nutrition and microbiome for human health	8
Single-cell transcriptomics of cardiac progenitors reveals functional subpopulations and their cooperative crosstalk in cardiac repair	7
Aging hallmarks of the primate ovary revealed by spatiotemporal transcriptomics	7

Platelet RNA enables accurate detection of ovarian cancer: an intercontinental, biomarker identification study	7
Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration	7
Single-cell profiling reveals Müller glia coordinate retinal intercellular communication during light/dark adaptation via thyroid hormone signaling	7
Ergothioneine and its congeners: anti-ageing mechanisms and pharmacophore biosynthesis	7
Isogenic human pluripotent stem cell disease models reveal ABRA deficiency underlies cTnT mutation-induced familial dilated cardiomyopathy	7
An engineered xCas12i with high activity, high specificity and broad PAM range	6
Epigenetic integrity of paternal imprints enhances the developmental potential of androgenetic haploid embryonic stem cells	6
PINK1 mediates neuronal survival in monkey	6
Modeling human pregastulation development by 3D culture of blastoids generated from primed-to-naïve transitioning intermediates	6
Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging	6
Radiation injury and gut microbiota-based treatment	6
Generation of developmentally competent oocytes and fertile mice from parthenogenetic embryonic stem cells	6
Serosurvey for SARS-CoV-2 among blood donors in Wuhan, China from September to December 2019	5
Longitudinal proteomic investigation of COVID-19 vaccination	5
Architecture of severe fever with thrombocytopenia syndrome virus	5
CRISPR-based screening identifies XPO7 as a positive regulator of senescence	5
Neuronal guidance genes in health and diseases	5
Join the club: ORP8 is a lipophagy receptor	5
Exploring unconventional attributes of red blood cells and their potential applications in biomedicine	5
Genomic instability as a major mechanism for acquired resistance to EGFR tyrosine kinase inhibitors in cancer	5
Innovative insights into extrachromosomal circular DNAs in gynecologic tumors and reproduction	5
Immunogenic molecules associated with gut bacterial cell walls: chemical structures, immune-modulating functions, and mechanisms	5
Tongue as a first-line immune organ?	5
Gut microbial methionine impacts circadian clock gene expression and reactive oxygen species level in host gastrointestinal tract	4
Maternal and infant microbiome: next-generation indicators and targets for intergenerational health and nutrition care	4
High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors	4
Human ESC-derived vascular cells promote vascular regeneration in a HIF-1α dependent manner	4
Single transmembrane GPCR modulating proteins: neither single nor simple	4
Sinoatrial node pacemaker cells: cardiomyocyte- or neuron-like cells?	4
MFSD12 affects glycosphingolipid metabolism by modulating lysosome homeostasis	4
Long way up: rethink diseases in light of phase separation and phase transition	4
Emerging clinical relevance of microbiome in cancer: promising biomarkers and therapeutic targets	4
Cellular polyploidy in organ homeostasis and regeneration	3
Applications of genetic code expansion technology in eukaryotes	3
Correction to: Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling	3
Phosphorylation of NF2 at Serine-13 by MAP4K family kinases mediates pathological angiogenesis	3
Cell-cycle length of medial ganglionic eminence progenitors contributes to interneuron fate	3
Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques	3
Cryo-EM structure of cannabinoid receptor CB1-β-arrestin complex	3
DNA methylation clocks for estimating biological age in Chinese cohorts	3
Governing glutaminolysis by regulation of glutaminase succinylation	3
Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15	3
Bilineage embryo-like structure from EPS cells can produce live mice with tetraploid trophectoderm	3
Systematicidentification of CRISPR off-target effects by CROss-seq	3
Platelet RNA signature independently predicts ovarian cancer prognosis by deep learning neural network model	3
Structural insights into signal transduction of the purinergic receptors P2Y1R and P2Y12R	3
The engagement of histone lysine methyltransferases with nucleosomes: structural basis, regulatory mechanisms, and therapeutic implications	3
Identification of FOXO1 as a geroprotector in human synovium through single-nucleus transcriptomic profiling	3
Spatially-resolved expression landscape and gene-regulatory network of human gastric corpus epithelium	3
Mechanism and design of allosteric activators of SIRT1	2
Strategies for generating mouse model resources of human disease	2
Alzheimer’s disease: insights into pathology, molecular mechanisms, and therapy	2
Aging-induced YTHDF aggregates impair mitochondrial function by trapping mitochondrial RNAs and suppressing their expression in the brain	2
Single-nucleus transcriptomics uncovers a geroprotective role of YAP in primate gingival aging	2
4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis	2
Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1	2
Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2 infection during early pregnancy	2
Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD	2
Dual role of lipids for genome stability and pluripotency facilitates full potency of mouse embryonic stem cells	2
Immunology of a unique biological structure: the Echinococcus laminated layer	2