OOIR: Observatory of International Research

Papers

(The median citation count of Protein & Cell is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy	819
A practical guide to amplicon and metagenomic analysis of microbiome data	368
Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids	281
The role of the gut microbiome and its metabolites in metabolic diseases	174
Mapping the epigenetic modifications of DNA and RNA	174
A human circulating immune cell landscape in aging and COVID-19	170
Ferroptosis, radiotherapy, and combination therapeutic strategies	167
Targeting the alternative bile acid synthetic pathway for metabolic diseases	143
The microbiome in inflammatory bowel diseases: from pathogenesis to therapy	131
Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332	123
Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2	115
Unexpected guests in the tumor microenvironment: microbiome in cancer	103
Insights into epigenetic patterns in mammalian early embryos	98
The potential of using blood circular RNA as liquid biopsy biomarker for human diseases	92
High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors	92
Mesenchymal stem cell therapy for acute respiratory distress syndrome: from basic to clinics	91
SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer	82
Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos	82
New avenues for systematically inferring cell-cell communication: through single-cell transcriptomics data	80
Pioneer of prostate cancer: past, present and the future of FOXA1	78
Mouse-adapted SARS-CoV-2 replicates efficiently in the upper and lower respiratory tract of BALB/c and C57BL/6J mice	74
RIP1-dependent linear and nonlinear recruitments of caspase-8 and RIP3 respectively to necrosome specify distinct cell death outcomes	73
Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients	70
Role of gut microbiota in identification of novel TCM-derived active metabolites	68
KIF2C: a novel link between Wnt/β-catenin and mTORC1 signaling in the pathogenesis of hepatocellular carcinoma	66

Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection	65
Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model	61
Gut microbes in cardiovascular diseases and their potential therapeutic applications	61
BMAL1 regulates mitochondrial fission and mitophagy through mitochondrial protein BNIP3 and is critical in the development of dilated cardiomyopathy	58
Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling	57
The mini player with diverse functions: extracellular vesicles in cell biology, disease, and therapeutics	57
TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2	52
Architecture of the herpesvirus genome-packaging complex and implications for DNA translocation	51
The function and regulation of TET2 in innate immunity and inflammation	49
Gut microbiota alterations are distinct for primary colorectal cancer and hepatocellular carcinoma	48
Lipids and membrane-associated proteins in autophagy	46
Non-enzymatic covalent modifications: a new link between metabolism and epigenetics	45
Single-nucleus transcriptomic landscape of primate hippocampal aging	44
Generation of a Hutchinson–Gilford progeria syndrome monkey model by base editing	43
Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development	40
Live cell imaging and proteomic profiling of endogenous NEAT1 lncRNA by CRISPR/Cas9-mediated knock-in	40
Sirt1 regulates testosterone biosynthesis in Leydig cells via modulating autophagy	40
Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis	40
Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation	39
Role of glycosylation in TGF-β signaling and epithelial-to-mesenchymal transition in cancer	39
Cytochrome P450 reductase (POR) as a ferroptosis fuel	38
Structures of a P4-ATPase lipid flippase in lipid bilayers	33
Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis	33
Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation	33
PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis	32
Pan-coronavirus fusion inhibitors as the hope for today and tomorrow	31
Structure of intact human MCU supercomplex with the auxiliary MICU subunits	30
Re-detectable positive SARS-CoV-2 RNA tests in patients who recovered from COVID-19 with intestinal infection	29
The expanded development and application of CRISPR system for sensitive nucleotide detection	28
POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation	28
Nuclear cGAS: sequestration and beyond	27
Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2	26
Therapeutic silencing miR-146b-5p improves cardiac remodeling in a porcine model of myocardial infarction by modulating the wound reparative phenotype	26
FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocardial infarction	26
A pair of transporters controls mitochondrial Zn2+ levels to maintain mitochondrial homeostasis	25
An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope	25
3D chromatin architecture and epigenetic regulation in cancer stem cells	25
Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response	25
FAK-targeting PROTAC as a chemical tool for the investigation of non-enzymatic FAK function in mice	24
Single cell RNA and immune repertoire profiling of COVID-19 patients reveal novel neutralizing antibody	24
The p21-activated kinases in neural cytoskeletal remodeling and related neurological disorders	23
O-GlcNAc transferase regulates centriole behavior and intraflagellar transport to promote ciliogenesis	23
Higher-order assemblies in immune signaling: supramolecular complexes and phase separation	23
Deciphering primate retinal aging at single-cell resolution	23
Structural changes of a bacteriophage upon DNA packaging and maturation	22
Primary cilia mediate Klf2-dependant Notch activation in regenerating heart	22
Broad spectrum antibiotic-degrading metallo-β-lactamases are phylogenetically diverse	20
Precise genome editing without exogenous donor DNA via retron editing system in human cells	19
METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth	19
Structural insights into the activation initiation of full-length mGlu1	19

Histone deacetylase 3 promotes innate antiviral immunity through deacetylation of TBK1	19
cGAS guards against chromosome end-to-end fusions during mitosis and facilitates replicative senescence	18
Cancer biology deciphered by single-cell transcriptomic sequencing	18
Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase	17
Loss of 4.1N in epithelial ovarian cancer results in EMT and matrix-detached cell death resistance	17
The best practice for microbiome analysis using R	16
The exploration of N6-deoxyadenosine methylation in mammalian genomes	16
Repurposing FDA-approved drugs for SARS-CoV-2 through an ELISA-based screening for the inhibition of RBD/ACE2 interaction	15
Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network	14
Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon	13
Genetic tracing of HCoV-19 for the re-emerging outbreak of COVID-19 in Beijing, China	13
Single-cell RNA-Seq analysis identified kidney progenitor cells from human urine	13
Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB2-AcpM2	13
Indiscriminate ssDNA cleavage activity of CRISPR-Cas12a induces no detectable off-target effects in mouse embryos	13
Sinoatrial node pacemaker cells share dominant biological properties with glutamatergic neurons	12
Integrative analysis of in vivo recording with single-cell RNA-seq data reveals molecular properties of light-sensitive neurons in mouse V1	12
Convergent evolution of SARS-CoV-2 in human and animals	12
METTL14 is a chromatin regulator independent of its RNA N 6-methyladenosine methyltransferase activity	12
Cellular metabolism and homeostasis in pluripotency regulation	12
Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization	12
Rnf20 deficiency in adipocyte impairs adipose tissue development and thermogenesis	11
Maternal heterozygous mutation in CHEK1 leads to mitotic arrest in human zygotes	11
Structural basis of INTAC-regulated transcription	11
RNA m6A meets transposable elements and chromatin	10
Microbiome research outlook: past, present, and future	10
A single-nucleus transcriptomic atlas of primate testicular aging reveals exhaustion of the spermatogonial stem cell reservoir and loss of Sertoli cell homeostasis	10
Molecular deconvolution of the neutralizing antibodies induced by an inactivated SARS-CoV-2 virus vaccine	10
The two-stage interaction of Ebola virus VP40 with nucleoprotein results in a switch from viral RNA synthesis to virion assembly/budding	9
SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling	9
Roles of Tet2 in meiosis, fertility and reproductive aging	9
Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging	9
Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes	9
Bi-FoRe: an efficient bidirectional knockin strategy to generate pairwise conditional alleles with fluorescent indicators	9
Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis	8
Crystal structure of the African swine fever virus structural protein p35 reveals its role for core shell assembly	8
How are MCPIP1 and cytokines mutually regulated in cancer-related immunity?	8
Restoration of FMRP expression in adult V1 neurons rescues visual deficits in a mouse model of fragile X syndrome	7
SIRT7 slows down stem cell aging by preserving heterochromatin: a perspective on the new discovery	7
Structure of African swine fever virus p15 reveals its dual role for membrane-association and DNA binding	7
Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids	7
OSMRβ mutants enhance basal keratinocyte differentiation via inactivation of the STAT5/KLF7 axis in PLCA patients	7
The microbiota–gut–brain axis and neurodevelopmental disorders	7
High resolution structure of hexameric herpesvirus DNA-packaging motor elucidates revolving mechanism and ends 20-year fervent debate	7
Graded and pan-neural disease phenotypes of Rett Syndrome linked with dosage of functional MeCP2	7
ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells	6
The impact of aging and COVID-19 on our immune system: a high-resolution map from single cell analysis	6
Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration	6
Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging	6
ORP8 acts as a lipophagy receptor to mediate lipid droplet turnover	6
PINK1 mediates neuronal survival in monkey	6
Platelet RNA enables accurate detection of ovarian cancer: an intercontinental, biomarker identification study	6
SIRT5 is important for bacterial infection by regulating insulin secretion and glucose homeostasis	6
Isogenic human pluripotent stem cell disease models reveal ABRA deficiency underlies cTnT mutation-induced familial dilated cardiomyopathy	6
Is oral microbiome of children able to maintain resistance and functional stability in response to short-term interference of ingesta?	6
Single-cell transcriptomics of cardiac progenitors reveals functional subpopulations and their cooperative crosstalk in cardiac repair	6
A YAP/TAZ-CD54 axis is required for CXCR2 −CD44 − tumor-specific neutrophils to suppress gastric cancer	6
Single-cell transcriptomic Atlas of mouse cochlear aging	6
Persisting lung pathogenesis and minimum residual virus in hamster after acute COVID-19	6
Impact of the microbiome on mosquito-borne diseases	6
Enhancing Prime Editing Efficiency and Flexibility with Tethered and Split pegRNAs	6
Serosurvey for SARS-CoV-2 among blood donors in Wuhan, China from September to December 2019	5
Rewiring ERBB3 and ERK signaling confers resistance to FGFR1 inhibition in gastrointestinal cancer harbored an ERBB3-E928G mutation	5
Regulation of aerobic glycolysis to decelerate tumor proliferation by small molecule inhibitors targeting glucose transporters	5
Nutri-microbiome epidemiology, an emerging field to disentangle the interplay between nutrition and microbiome for human health	5
mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells	5
Recent progress and challenges in the treatment of spinal cord injury	5
Microbial sensing in the intestine	5
Modeling human pregastulation development by 3D culture of blastoids generated from primed-to-naïve transitioning intermediates	5
Generation of developmentally competent oocytes and fertile mice from parthenogenetic embryonic stem cells	5
DUB-independent regulation of pVHL by OTUD6B suppresses hepatocellular carcinoma	4
BMP7 expression in mammalian cortical radial glial cells increases the length of the neurogenic period	4
Epigenetic integrity of paternal imprints enhances the developmental potential of androgenetic haploid embryonic stem cells	4
ZFP281 recruits polycomb repressive complex 2 to restrict extraembryonic endoderm potential in safeguarding embryonic stem cell pluripotency	4
The ubiquitin codes in cellular stress responses	4
A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes	4
APOE-mediated suppression of the lncRNA MEG3 protects human cardiovascular cells from chronic inflammation	4
Tongue as a first-line immune organ?	4
“Sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interaction	4
Ergothioneine and its congeners: anti-ageing mechanisms and pharmacophore biosynthesis	4
CRISPR-assisted transcription activation by phase-separation proteins	4