Protein & Cell

Article	Citations
Withdrawn as Duplicate: Remembering the Scholar Ding Ying: The Father of Chinese Rice-Farming Science	286
Gene print-based cell subtypes annotation of human disease across heterogeneous datasets with gPRINT	246
Pan Shuh: the founding figure of modern Chinese psychology	159
DCK confers sensitivity of DCTD-positive cancer cells to oxidized methylcytidines	138
One step, two functions: the mechanism of the ABCH class of transporter serving barrier construction and detoxification in insects	119
Unfolding HBx for an epigenetic switch of HBV cccDNA minichromosome	108
An improved method for the detection of double-stranded RNA suitable for quality control of mRNA vaccines	78
Gut microbial methionine impacts circadian clock gene expression and reactive oxygen species level in host gastrointestinal tract	76
JMJD1C forms condensate to facilitate a RUNX1-dependent gene expression program shared by multiple types of AML cells	64
Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging	58
DHA, a potentially therapeutic lipid for myocardial infarction	57
Microbiome research outlook: past, present, and future	56
Architecture of severe fever with thrombocytopenia syndrome virus	50
Endoplasmic reticulum membrane remodeling by targeting reticulon-4 induces pyroptosis to facilitate antitumor immune	48
Spatially-resolved expression landscape and gene-regulatory network of human gastric corpus epithelium	47
ARID1A IDR targets EWS-FLI1 condensates and finetunes chromatin remodeling	44
Anthrax lethal toxin and tumor necrosis factor-α synergize on intestinal epithelia to induce mouse death	44
Dynamin 1-mediated endocytic recycling of glycosylated N-cadherin sustains the plastic mesenchymal state to promote ovarian cancer metastasis	42
Strategies for generating mouse model resources of human disease	40
3D chromatin dynamics in cellular neuroendocrine transformation	38
Inheritance and advancement in biochemistry: the pioneering research of Szu-Chih Liu	34
A single-cell transcriptomic landscape characterizes the endocrine system aging in the mouse	33
NSUN2‑mediated epitranscriptomic and ubiquitin modulation of Nipah virus matrix protein reveals a dual-targeting antiviral strategy	33
Efficient clustered, regularly interspaced short palindromic repeats-based gene activation using combinatorial human transcription activation domains	30
Mutations in the SARS-CoV-2 spike receptor binding domain and their delicate balance between ACE2 affinity and antibody evasion	30

Cryo-EM structures of Nipah virus polymerase complex reveal highly varied interactions between L and P proteins among paramyxoviruses	30
Correction to: Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer	29
An orally-available monovalent SMAC mimetic compound as a broad-spectrum antiviral	28
A long non-coding RNA LncSync regulates mouse cardiomyocyte homeostasis and cardiac hypertrophy through coordination of miRNA actions	28
Pasteurized Akkermansia muciniphila promotes GP2 expression in microfold cells and facilitates Salmonella infection	27
Restoring the FOXO1 geroprotective pathway via seno-resistant mesenchymal progenitor cells alleviates primate epididymal aging	27
A hnRNPA2B1 agonist effectively inhibits HBV and SARS-CoV-2 omicronin vivo	27
Correction to: SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer	26
Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2 infection during early pregnancy	26
High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors	25
Long-term in vivo chimeric cells tracking in non-human primate	25
Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamine	23
Accumulation of newly synthesized docosahexaenoic acid plays an essential role in heart regeneration	23
Primate abnormal spindle-like microcephaly-associated knockout causes severe microcephaly and oligodendrocyte loss in the brain	23
Tuning the Hsp70 chaperone cycle: emerging roles of GrpE-like nucleotide exchange factors in proteostasis and organelle function	23
Tumor cell GPX4 dictates triacylglycerol metabolism for ferroptosis susceptibility and immune evasion of NSCLC	22
Microbial sensing in the intestine	22
Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis	21
Adenosine-to-inosine RNA editing in cancer: molecular mechanisms and downstream targets	21
Advances in gene and cellular therapeutic approaches for Huntington’s disease	21
Correction to: Adenosine-to-inosine RNA editing in cancer: molecular mechanisms and downstream targets	19
Radiation injury and gut microbiota-based treatment	19
What we can learn from hibernators and other adapted animals about organ transplantation: mechanisms of cold resistance and enhanced regeneration	19
Systematicidentification of CRISPR off-target effects by CROss-seq	18
Hunting out the repeat expansion in Huntington’s pigs	17
Single transmembrane GPCR modulating proteins: neither single nor simple	17
Glutamine signaling specifically activates c-Myc and Mcl-1 to facilitate cancer cell proliferation and survival	16
Endosomal catabolism of phosphatidylinositol 4,5-bisphosphate is fundamental in building resilience against pathogens	16
Secreted proteins in treating metabolic dysfunction-associated steatotic liver disease: from bench towards bedside	16
SMURF1: a promising target for colon cancer therapy	16
The microbiota–gut–brain axis and neurodevelopmental disorders	15
Oncogenic role of the SLC7A13-SLC3A1 cystine transporter in human luminal breast cancer and its cryo-EM structure	15
Boundless love: a German Professor Uli Schwarz in China	15
Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration	14
Correction to: DHA, a potentially therapeutic lipid for myocardial infarction	14
Synergistic innovation in organ-on-a-chip and organoid technologies: reshaping the future of disease modeling, drug development, and precision medicine	14
Aberrant outputs of cerebellar nuclei and targeted rescue of social deficits in an autism mouse model	14
Systematic characterization of full-length RNA isoforms in human colorectal cancer at single-cell resolution	14
Sung Shu Chien: The founder of modern Chinese botany	13
Single-nucleus transcriptomics uncovers a geroprotective role of YAP in primate gingival aging	13
Syn3, a newly developed cyclic peptide and BDNF signaling enhancer, ameliorates retinal ganglion cell degeneration in diabetic retinopathy	13
Virological research history in China: a century of profiling virologists’ contributions and virological innovations	12
Degeneration Directory: a multi-omics web resource for degenerative diseases	12
Tanjun Tong: a pioneer of cellular senescence and aging mechanism research in China	12
Correction to: Endothelial-to-Osteoblast Conversion maintains bone homeostasis through Kindlin-2/Piezo1/TGFβ/Runx2 axis	12
The chordata olfactory receptor database	12
Structural studies promote vaccine development: lessons from African swine fever virus	12
A molecular brake that modulates spliceosome pausing at detained introns contributes to neurodegeneration	11
Join the club: ORP8 is a lipophagy receptor	11
Human ESC-derived vascular cells promote vascular regeneration in a HIF-1α dependent manner	11

Platelet RNA signature independently predicts ovarian cancer prognosis by deep learning neural network model	11
MMP-9 regulates disulphide isomerase activity of TGM2 to enhance fusion glycoprotein-mediated syncytium formation of respiratory syncytial virus	10
Kechun Lin: a pioneer of biophysics explorations in China	10
Platelet RNA enables accurate detection of ovarian cancer: an intercontinental, biomarker identification study	10
RNA helicase MTR4 drives tumorigenesis of nasopharyngeal carcinoma by regulating the expression of key cell cycle genes	10
Bardoxolone methyl blocks the efflux of Zn2+ by targeting hZnT1 to inhibit the proliferation and metastasis of cervical cancer	10
Gut dysbiosis impairs intestinal renewal and lipid absorption in Scarb2 deficiency-associated neurodegeneration	10
The role of parkin in monkey	10
Whole-exome sequencing identifies ECPAS as a novel potentially pathogenic gene in multiple hereditary families with nonsyndromic orofacial cleft	9
Ergothioneine and its congeners: anti-ageing mechanisms and pharmacophore biosynthesis	9
Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging	9
Structural basis of INTAC-regulated transcription	9
Cryo-EM structure of human κ-opioid receptor-Gi complex bound to an endogenous agonist dynorphin A	9
PDHX acetylation facilitates tumor progression by disrupting PDC assembly and activating lactylation-mediated gene expression	9
Advances in multi-omics for esophageal squamous cell carcinoma: diagnostic, prognostic, and therapeutic perspectives	8
Optimized derivation and culture system of human naïve pluripotent stem cells with enhanced DNA methylation status and genomic stability	8
Harnessing human tumor organoids for cancer modeling and precision therapy	8
Noncoding RNA Terc-53 and hyaluronan receptor Hmmr regulate aging in mice	8
Human meibomian gland organoids to study epithelial homeostasis and dysfunction	8
The chemical reprogramming of unipotent adult germ cells towards authentic pluripotency and de novo establishment of imprinting	8
Human 8-cell embryos enable efficient induction of disease-preventive mutations without off-target effect by cytosine base editor	7
Tumor cell intrinsic dsRNA innate immune response triggered by PARP inhibitor is compromised in BRCA1-deficient breast cancer by repressing IRF3	7
An engineered xCas12i with high activity, high specificity and broad PAM range	7
MultiKano: an automatic cell type annotation tool for single-cell multi-omics data based on Kolmogorov–Arnold network and data augmentation	7
Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids	7
YME1L overexpression exerts pro-tumorigenic activity in glioma by promoting Gαi1 expression and Akt activation	7
Stress granules and organelles: coordinating cellular responses in health and disease	7
The p15 protein is a promising immunogen for developing protective immunity against African swine fever virus	7
Genome-wide investigation of transcription factor footprints and dynamics using cFOOT-seq	7
Molecular basis of high-torque transmission of the Vibrio polar flagellar motor	7
Macrophages suppress cardiac reprogramming of fibroblasts in vivo via IFN-mediated intercellular self-stimulating circuit	7
Structural and mechanistic insights into symmetry conversion in plant GORK K+ channel regulation	7
A minimally invasive, fast on/off “odorgenetic” method to manipulate physiology	7
A novel loop-structure-based bispecific CAR that targets CD19 and CD22 with enhanced therapeutic efficacy against B-cell malignancies	7
BiFC and FACS-based CRISPR screening revealed that QKI promotes PABPN1 LLPS in colorectal cancer cells	7
“Sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interaction	7
Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques	6
Phase separation of DUX family proteins drives totipotent-like state via 3D genome reorganization and retrotransposon activation	6
Lamin C conserves DNA replication factors via phase separation during oxidative stress for DNA replication recovery	6
Jiangsen Mao: a pioneer in Chinese hepatitis A vaccine and interferon research, a virologist at the forefront of times	6
Patient‑specific profiling of TCR‑T cell efficacy enabled by a rapid and standardized reporter system	6
Specific pathogen free ten gene-edited donor pigs for xenotransplantation	6
Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15	6
Setd2 overexpression rescues bivalent gene expression during SCNT-mediated ZGA	6
CTCF’s loop-independent functions prevail over chromatin looping in the acute degradation system	6
IL-24 promotes atopic dermatitis-like inflammation through driving MRSA-induced allergic responses	6
Lipid-gated “phosphorylation code” for TCR graded signaling and T-cell exhaustion	5
METTL14 is a chromatin regulator independent of its RNA N 6-methyladenosine methyltransferase activity	5
Single-cell transcriptomic Atlas of mouse cochlear aging	5
CRL3 E3 ligase regulates glutamine and cystine metabolisms	5
DNA-triggered AIM2 condensation orchestrates immune activation and regulation	5
MAAD: multidimensional antiviral antibody database	5
Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond	5
Dual role of lipids for genome stability and pluripotency facilitates full potency of mouse embryonic stem cells	5
CARM1 drives triple-negative breast cancer progression by coordinating with HIF1A	5
Molecular insights into Candida auris glycosylphosphatidylinositol transamidase	5
Engineering oncolytic bacteria as precision cancer therapeutics: design principles, therapeutic strategies, and translational perspectives	4
GA-binding protein alpha ensures proper blastocyst development by suppressing SMAD3-mediated transforming growth factor-beta signaling	4
Phosphorylation of NF2 at Serine-13 by MAP4K family kinases mediates pathological angiogenesis	4
Face off: a metabolic enzyme becomes a protein phosphatase	4
Correction to: Engineered extracellular vesicles enable high-efficient delivery of intracellular therapeutic proteins	4
Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice	4
APOE-mediated suppression of the lncRNA MEG3 protects human cardiovascular cells from chronic inflammation	4
Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD	4
p21/Zbtb18 repress the expression of cKit to regulate the self-renewal of hematopoietic stem cells	4
EZH2 in non-cancerous diseases: expanding horizons	4
Molecular architecture of mammalian pyruvate dehydrogenase complex	4
Systematic analyses uncover plasma proteins linked to incident cardiovascular diseases	4
Correction to: EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation	4
Skin organoid transplantation promotes tissue repair with scarless in frostbite	4
A promising clinical technique to rescue women’s ovarian aging: engineered stem cell-based therapy with the help of AI	4
Emerging roles of RNA N4-acetylcytidine modification in reproductive health	3
Structural basis of arpin homodimerization reveals cooperative inhibition of the Arp2/3 complex through dual-site engagement	3
Correction to: ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells	3
Antiviral activity of lipoxygenase against severe fever with thrombocytopenia syndrome virus	3
Spatiotemporal Ca2+ nanodomain remodeling at MERCS regulates mitochondrial proteostasis	3
The ubiquitin codes in cellular stress responses	3
Comprehensive transcriptional atlas of human adenomyosis deciphered by the integration of single-cell RNA-sequencing and spatial transcriptomics	3
Endosomes as central hubs of interorganellar communication and cellular homeostasis	3
Pleural cavity macrophages promote lung tumor establishment through tissue invasion	3

A programmable platform enabling targeted chromosome substitution and cross-species stability profiling	3
A CRISPR activation screen identifies genes that enhance SARS-CoV-2 infection	3
rhMG53 induces pharmacological preconditioning by acting as an agonistic ligand of c-met	3
Discovery of CCDC188 gene as a novel genetic target for human acephalic spermatozoa syndrome	3
Endothelial-to-Osteoblast Conversion maintains bone homeostasis through Kindlin-2/Piezo1/TGFβ/Runx2 axis	3
RADICAL: a rationally designed ion channel activated by ligand for chemogenetics	3
Investigating regional-specific gut microbial distribution: an uncharted territory in disease therapeutics	3
NDFIP1 limits cellular TAZ accumulation via exosomal sorting to inhibit NSCLC proliferation	3
ORP8 acts as a lipophagy receptor to mediate lipid droplet turnover	3
SARS-CoV-2 ORF8 does not function in the nucleus as a histone mimic	3
Professor Delong Su: a pioneer in Schistosomiasis Eradication in China	2
In memory of the well-renowned Chinese cellular biologist Shien Sher-Pu	2
Asymmetric reconstruction of the aquareovirus core at near-atomic resolution and mechanism of transcription initiation	2
Structure-based engineering of the midnolin-proteasome pathway for targeted protein degradation	2
FOXO3-engineered human mesenchymal stem cells efficiently enhance post-ischemic stroke functional rehabilitation	2
Periosteal reaction: a natural extracellular matrix barrier to prevent cancer-bone invasion	2
Structure, identification, and characterization of the RibD-enolase complex in Francisella	2
Correction to: DJ-1 is dispensable for human stem cell homeostasis	2
Targeting IRG1 in tumor-associated macrophages for cancer therapy	2
Ko Kuei Chen: A Pioneer of Modern Pharmacological Research in China	2
Lentivirus-modified hematopoietic stem cell gene therapy for advanced symptomatic juvenile metachromatic leukodystrophy: a long-term follow-up pilot study	2
Centered on child health: Zhu Futang and the foundations of pediatrics and measles prevention in China	2
Deciphering the placental abnormalities associated with somatic cell nuclear transfer at single-nucleus resolution	2
Structural basis of allosteric and bitopic ligands binding in sphingosine-1-phosphate receptors 2 and 3	2
Mechanism and design of allosteric activators of SIRT1	2
Mechanistic insights into the GEF activity of the human MON1A/CCZ1/C18orf8 complex	2
Zhu Xi: A Pioneer of Experimental Biology	2
RNA G-quadruplex (rG4) exacerbates cellular senescence by mediating ribosome pausing	2
Glutamine synthetase sustains cortical circuit development via mTOR-mediated astrocyte maturation	2
Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation	2
GlycoRNA research: from unknown unknowns to known unknowns	2