Protein & Cell

Article	Citations
Oncomicrobial vaccines mitigate tumor progression via precisely targeting oncomicrobes in mice	254
Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond	146
Bingwen Zou (Ping-wen Tsou): pioneer of agricultural higher education in China	113
“Always learn today, stand ready to act tomorrow”—Po Tien: A pioneer of Virology in China	95
DCK confers sensitivity of DCTD-positive cancer cells to oxidized methylcytidines	87
The Host Microbiota is Associated with the Occurrence and Development of Esophageal Squamous Cell Carcinoma	77
Ko Kuei Chen: A Pioneer of Modern Pharmacological Research in China	76
A core epitope targeting antibody of SARS-CoV-2	61
In memory of the well-renowned Chinese cellular biologist Shien Sher-Pu	52
Single-cell analysis reveals an Angpt4-initiated EPDC-EC-CM cellular coordination cascade during heart regeneration	49
Zhu Xi: A Pioneer of Experimental Biology	39
Richard Ho-Ping Sia: pioneer of infectiology in China	38
Cell-cycle length of medial ganglionic eminence progenitors contributes to interneuron fate	37
4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis	36
Pan Shuh: the founding figure of modern Chinese psychology	36
Anthrax lethal toxin and tumor necrosis factor-α synergize on intestinal epithelia to induce mouse death	33
Spatially-resolved expression landscape and gene-regulatory network of human gastric corpus epithelium	31
JMJD1C forms condensates to facilitate a RUNX1-dependent gene expression program shared by multiple types of AML cells	27
Correction to: Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer	27
An improved method for the detection of double-stranded RNA suitable for quality control of mRNA vaccines	26
Jiangsen Mao: a pioneer in Chinese hepatitis A vaccine and interferon research, a virologist at the forefront of times	24
Persisting lung pathogenesis and minimum residual virus in hamster after acute COVID-19	24
Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging	22
Boundless love: a German Professor Uli Schwarz in China	22
Bilineage embryo-like structure from EPS cells can produce live mice with tetraploid trophectoderm	21

IL-24 promotes atopic dermatitis-like inflammation through driving MRSA-induced allergic responses	21
Dual role of lipids for genome stability and pluripotency facilitates full potency of mouse embryonic stem cells	20
Exploring unconventional attributes of red blood cells and their potential applications in biomedicine	20
CRL3 E3 ligase regulates glutamine and cystine metabolisms	19
Asymmetric reconstruction of the aquareovirus core at near-atomic resolution and mechanism of transcription initiation	19
Resolving the lineage relationship between malignant cells and vascular cells in glioblastomas	17
Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration	16
Isogenic human pluripotent stem cell disease models reveal ABRA deficiency underlies cTnT mutation-induced familial dilated cardiomyopathy	14
Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15	14
Gut microbial methionine impacts circadian clock gene expression and reactive oxygen species level in host gastrointestinal tract	13
Identification of FOXO1 as a geroprotector in human synovium through single-nucleus transcriptomic profiling	13
Architecture of severe fever with thrombocytopenia syndrome virus	13
ARID1A IDR targets EWS-FLI1 condensates and finetunes chromatin remodeling	12
Recent progress and challenges in the treatment of spinal cord injury	12
Cancer biology deciphered by single-cell transcriptomic sequencing	11
Remembering the Scholar Ding Ying: The Father of Chinese Rice-Farming Science	11
Microbiome research outlook: past, present, and future	11
METTL14 is a chromatin regulator independent of its RNA N 6-methyladenosine methyltransferase activity	11
METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth	11
Alzheimer’s disease: insights into pathology, molecular mechanisms, and therapy	10
A third dose of inactivated vaccine augments the potency, breadth, and duration of anamnestic responses against SARS-CoV-2	10
Endoplasmic reticulum membrane remodeling by targeting reticulon-4 induces pyroptosis to facilitate antitumor immune	10
Correction to: The nucleocapsid protein of rice stripe virus in cell nuclei of vector insect regulates viral replication	10
Single-cell transcriptomic Atlas of mouse cochlear aging	10
Aberrant outputs of cerebellar nuclei and targeted rescue of social deficits in an autism mouse model	10
Molecular deconvolution of the neutralizing antibodies induced by an inactivated SARS-CoV-2 virus vaccine	9
RBM46 is essential for gametogenesis and functions in post-transcriptional roles affecting meiotic cohesin subunits	9
Sung Shu Chien: The founder of modern Chinese botany	9
Maternal heterozygous mutation in CHEK1 leads to mitotic arrest in human zygotes	8
MFSD12 affects glycosphingolipid metabolism by modulating lysosome homeostasis	8
Suppression of USP8 sensitizes cells to ferroptosis via SQSTM1/p62-mediated ferritinophagy	8
Immunogenic molecules associated with gut bacterial cell walls: chemical structures, immune-modulating functions, and mechanisms	8
Degeneration Directory: a multi-omics web resource for degenerative diseases	7
Single-nucleus transcriptomic landscape of primate hippocampal aging	7
Microbiome, metabolome, and transcriptome analyses in esophageal squamous cell carcinoma: insights into immune modulation by F. nucleatum	7
Professor Delong Su: a pioneer in Schistosomiasis Eradication in China	7
Mutations in the SARS-CoV-2 spike receptor binding domain and their delicate balance between ACE2 affinity and antibody evasion	7
Lentivirus-modified hematopoietic stem cell gene therapy for advanced symptomatic juvenile metachromatic leukodystrophy: a long-term follow-up pilot study	7
Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD	7
Strategies for generating mouse model resources of human disease	7
Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation	6
CARM1 drives triple-negative breast cancer progression by coordinating with HIF1A	6
CRISPR-assisted transcription activation by phase-separation proteins	6
The Icarian flight of antibody-drug conjugates: target selection amidst complexity and tackling adverse impacts	6
An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope	6
Single-nucleus transcriptomics uncovers a geroprotective role of YAP in primate gingival aging	6
Skeletal stem cells in bone development, homeostasis, and disease	6
Tanjun Tong: a pioneer of cellular senescence and aging mechanism research in China	6
A single-nucleus transcriptomic atlas of primate testicular aging reveals exhaustion of the spermatogonial stem cell reservoir and loss of Sertoli cell homeostasis	6
Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model	5

Fan-lan Tai: A Pioneer of Plant Pathology and Mycology in China	5
Correction to: EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation	5
Syn3, a newly developed cyclic peptide and BDNF signaling enhancer, ameliorates retinal ganglion cell degeneration in diabetic retinopathy	5
PKM2, the “K+ sink” in the tumor interstitial fluid	5
A long non-coding RNA LncSync regulates mouse cardiomyocyte homeostasis and cardiac hypertrophy through coordination of miRNA actions	5
p21/Zbtb18 repress the expression of cKit to regulate the self-renewal of hematopoietic stem cells	5
Governing glutaminolysis by regulation of glutaminase succinylation	5
RECOLLECTION Hsien-wen Wu: A founder of the studies of Ichthyology in China	5
Ferroptosis, radiotherapy, and combination therapeutic strategies	5
Skin organoid transplantation promotes tissue repair with scarless in frostbite	4
High-throughput single-microbe RNA sequencing reveals adaptive state heterogeneity and host-phage activity associations in human gut microbiome	4
APOE-mediated suppression of the lncRNA MEG3 protects human cardiovascular cells from chronic inflammation	4
METTL9-catalyzed histidine methylation of S100A9 suppresses the anti-Staphylococcus aureus activity of neutrophils	4
IDDoR: A novel reporter mouse system for simultaneous and quantitative in vivo analysis of both DNA double-strand break repair pathways	4
An orally-available monovalent SMAC mimetic compound as a broad-spectrum antiviral	4
The engagement of histone lysine methyltransferases with nucleosomes: structural basis, regulatory mechanisms, and therapeutic implications	4
Epigenetic integrity of paternal imprints enhances the developmental potential of androgenetic haploid embryonic stem cells	4
Phosphorylation of NF2 at Serine-13 by MAP4K family kinases mediates pathological angiogenesis	4
Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon	3
A hnRNPA2B1 agonist effectively inhibits HBV and SARS-CoV-2 omicronin vivo	3
PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis	3
Generation of developmentally competent oocytes and fertile mice from parthenogenetic embryonic stem cells	3
mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells	3
Mechanism and design of allosteric activators of SIRT1	3
Join the club: ORP8 is a lipophagy receptor	3
Correction to: Low-dose chloroquine treatment extends the lifespan of aged rats	3
Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice	3
Indiscriminate ssDNA cleavage activity of CRISPR-Cas12a induces no detectable off-target effects in mouse embryos	3
Correction to: Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling	3
Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos	3
Correction to: Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells	3
Deciphering the placental abnormalities associated with somatic cell nuclear transfer at single-nucleus resolution	3
Human ESC-derived vascular cells promote vascular regeneration in a HIF-1α dependent manner	3
The chordata olfactory receptor database	3
Correction to: Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model	3
Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2 infection during early pregnancy	3
Remembering the scholar Ding Ying: The father of Chinese rice-farming science	2
Virological research history in China: a century of profiling virologists’ contributions and virological innovations	2
The exploration of N6-deoxyadenosine methylation in mammalian genomes	2
Emerging clinical relevance of microbiome in cancer: promising biomarkers and therapeutic targets	2
FOXO3-engineered human mesenchymal stem cells efficiently enhance post-ischemic stroke functional rehabilitation	2
High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors	2
Aging hallmarks of the primate ovary revealed by spatiotemporal transcriptomics	2
Cytochrome P450 reductase (POR) as a ferroptosis fuel	2
Correction to: SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer	2
A molecular brake that modulates spliceosome pausing at detained introns contributes to neurodegeneration	2
The best practice for microbiome analysis using R	2
Quantitative real-time in vitro transcription assay (QRIVTA) for transcriptional regulation studies	1
A promising clinical technique to rescue women’s ovarian aging: engineered stem cell-based therapy with the help of AI	1
Structural basis of INTAC-regulated transcription	1
Innovative insights into extrachromosomal circular DNAs in gynecologic tumors and reproduction	1
Ergothioneine and its congeners: anti-ageing mechanisms and pharmacophore biosynthesis	1
DNA methylation clocks for estimating biological age in Chinese cohorts	1
Whole-exome sequencing identifies ECPAS as a novel potentially pathogenic gene in multiple hereditary families with nonsyndromic orofacial cleft	1
Platelet RNA signature independently predicts ovarian cancer prognosis by deep learning neural network model	1
A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes	1
Face off: a metabolic enzyme becomes a protein phosphatase	1
Ca2+ binding to the C2E domain of otoferlin is required for hair cell exocytosis and hearing	1
Correction to: Enhancing prime editing efficiency and flexibility with tethered and split pegRNAs	1
Longitudinal proteomic investigation of COVID-19 vaccination	1
RNA helicase MTR4 drives tumorigenesis of nasopharyngeal carcinoma by regulating the expression of key cell cycle genes	1
Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging	1
Sinoatrial node pacemaker cells: cardiomyocyte- or neuron-like cells?	1
PDHX acetylation facilitates tumor progression by disrupting PDC assembly and activating lactylation-mediated gene expression	1
Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization	1
High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors	1
Aging-induced YTHDF aggregates impair mitochondrial function by trapping mitochondrial RNAs and suppressing their expression in the brain	1
Biallelic variants in RBM42 cause a multisystem disorder with neurological, facial, cardiac, and musculoskeletal involvement	1
A tribute to Professor Yong Zhao	1
Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamine	1
Endothelial-to-Osteoblast Conversion maintains bone homeostasis through Kindlin-2/Piezo1/TGFβ/Runx2 axis	1
Platelet RNA enables accurate detection of ovarian cancer: an intercontinental, biomarker identification study	1
ILF3 safeguards telomeres from aberrant homologous recombination as a telomeric R-loop reader	1
Cryo-EM structure of human κ-opioid receptor-Gi complex bound to an endogenous agonist dynorphin A	1
Long-term in vivo chimeric cells tracking in non-human primate	1
A YAP/TAZ-CD54 axis is required for CXCR2 −CD44 − tumor-specific neutrophils to suppress gastric cancer	1
The role of parkin in monkey	1
Cryo-EM structure of cannabinoid receptor CB1-β-arrestin complex	1
Nutri-microbiome epidemiology, an emerging field to disentangle the interplay between nutrition and microbiome for human health	1
Structural insights into signal transduction of the purinergic receptors P2Y1R and P2Y12R	1

Engineered extracellular vesicles enable high-efficient delivery of intracellular therapeutic proteins	1
Applications of genetic code expansion technology in eukaryotes	1
Modeling human pregastulation development by 3D culture of blastoids generated from primed-to-naïve transitioning intermediates	1
Correction to: Macrophages suppress cardiac reprogramming of fibroblasts in vivo via IFN-mediated intercellular self-stimulating circuit	1
Gut dysbiosis impairs intestinal renewal and lipid absorption in Scarb2 deficiency-associated neurodegeneration	1
Structure basis for allosteric regulation of lymphocytic choriomeningitis virus polymerase function by Z matrix protein	1