OOIR: Observatory of International Research

Papers

(The median citation count of Protein & Cell is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
“Always learn today, stand ready to act tomorrow”—Po Tien: A pioneer of Virology in China	156
Gut microbial methionine impacts circadian clock gene expression and reactive oxygen species level in host gastrointestinal tract	112
An improved method for the detection of double-stranded RNA suitable for quality control of mRNA vaccines	109
DCK confers sensitivity of DCTD-positive cancer cells to oxidized methylcytidines	83
Pan Shuh: the founding figure of modern Chinese psychology	77
Anthrax lethal toxin and tumor necrosis factor-α synergize on intestinal epithelia to induce mouse death	62
Unfolding HBx for an epigenetic switch of HBV cccDNA minichromosome	52
Architecture of severe fever with thrombocytopenia syndrome virus	51
Gene print-based cell subtypes annotation of human disease across heterogeneous datasets with gPRINT	51
Remembering the Scholar Ding Ying: The Father of Chinese Rice-Farming Science	45
Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging	44
ARID1A IDR targets EWS-FLI1 condensates and finetunes chromatin remodeling	41
Spatially-resolved expression landscape and gene-regulatory network of human gastric corpus epithelium	40
Endoplasmic reticulum membrane remodeling by targeting reticulon-4 induces pyroptosis to facilitate antitumor immune	39
JMJD1C forms condensate to facilitate a RUNX1-dependent gene expression program shared by multiple types of AML cells	37
Cancer biology deciphered by single-cell transcriptomic sequencing	35
Microbiome research outlook: past, present, and future	33
Dynamin 1-mediated endocytic recycling of glycosylated N-cadherin sustains the plastic mesenchymal state to promote ovarian cancer metastasis	31
Cryo-EM structures of Nipah virus polymerase complex reveal highly varied interactions between L and P proteins among paramyxoviruses	27
An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope	27
Strategies for generating mouse model resources of human disease	25
A hnRNPA2B1 agonist effectively inhibits HBV and SARS-CoV-2 omicronin vivo	23
Mutations in the SARS-CoV-2 spike receptor binding domain and their delicate balance between ACE2 affinity and antibody evasion	23
Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2 infection during early pregnancy	23
Pasteurized Akkermansia muciniphila promotes GP2 expression in microfold cells and facilitates Salmonella infection	22

An orally-available monovalent SMAC mimetic compound as a broad-spectrum antiviral	22
A long non-coding RNA LncSync regulates mouse cardiomyocyte homeostasis and cardiac hypertrophy through coordination of miRNA actions	22
A tribute to Professor Yong Zhao	21
High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors	21
Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamine	21
Correction to: SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer	21
Long-term in vivo chimeric cells tracking in non-human primate	18
RNA m6A meets transposable elements and chromatin	18
Radiation injury and gut microbiota-based treatment	17
Adenosine-to-inosine RNA editing in cancer: molecular mechanisms and downstream targets	16
Advances in gene and cellular therapeutic approaches for Huntington’s disease	16
Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis	15
Microbial sensing in the intestine	15
Endosomal catabolism of phosphatidylinositol 4,5-bisphosphate is fundamental in building resilience against pathogens	15
Hunting out the repeat expansion in Huntington’s pigs	14
Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis	14
SMURF1: a promising target for colon cancer therapy	13
Systematicidentification of CRISPR off-target effects by CROss-seq	13
Correction to: Adenosine-to-inosine RNA editing in cancer: molecular mechanisms and downstream targets	13
Secreted proteins in treating metabolic-dysfunction associated steatotic liver disease: from bench towards bedside	13
Single transmembrane GPCR modulating proteins: neither single nor simple	12
Boundless love: a German Professor Uli Schwarz in China	12
The microbiota–gut–brain axis and neurodevelopmental disorders	12
Correction to: The nucleocapsid protein of rice stripe virus in cell nuclei of vector insect regulates viral replication	11
Aberrant outputs of cerebellar nuclei and targeted rescue of social deficits in an autism mouse model	11
Tanjun Tong: a pioneer of cellular senescence and aging mechanism research in China	11
Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration	11
Degeneration Directory: a multi-omics web resource for degenerative diseases	11
Sung Shu Chien: The founder of modern Chinese botany	11
Syn3, a newly developed cyclic peptide and BDNF signaling enhancer, ameliorates retinal ganglion cell degeneration in diabetic retinopathy	11
Epigenetic integrity of paternal imprints enhances the developmental potential of androgenetic haploid embryonic stem cells	10
A molecular brake that modulates spliceosome pausing at detained introns contributes to neurodegeneration	10
mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells	10
Single-nucleus transcriptomics uncovers a geroprotective role of YAP in primate gingival aging	10
Virological research history in China: a century of profiling virologists’ contributions and virological innovations	9
Human ESC-derived vascular cells promote vascular regeneration in a HIF-1α dependent manner	9
Join the club: ORP8 is a lipophagy receptor	9
The chordata olfactory receptor database	9
Cryo-EM structure of human κ-opioid receptor-Gi complex bound to an endogenous agonist dynorphin A	8
Gut dysbiosis impairs intestinal renewal and lipid absorption in Scarb2 deficiency-associated neurodegeneration	8
The role of parkin in monkey	8
Whole-exome sequencing identifies ECPAS as a novel potentially pathogenic gene in multiple hereditary families with nonsyndromic orofacial cleft	8
Structural basis of INTAC-regulated transcription	8
PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis	8
Governing glutaminolysis by regulation of glutaminase succinylation	8
RNA helicase MTR4 drives tumorigenesis of nasopharyngeal carcinoma by regulating the expression of key cell cycle genes	8
Platelet RNA signature independently predicts ovarian cancer prognosis by deep learning neural network model	7
A novel loop-structure-based bispecific CAR that targets CD19 and CD22 with enhanced therapeutic efficacy against B-cell malignancies	7
“Sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interaction	7
PDHX acetylation facilitates tumor progression by disrupting PDC assembly and activating lactylation-mediated gene expression	7

Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging	7
BiFC and FACS-based CRISPR screening revealed that QKI promotes PABPN1 LLPS in colorectal cancer cells	7
MultiKano: an automatic cell type annotation tool for single-cell multi-omics data based on Kolmogorov–Arnold network and data augmentation	7
Platelet RNA enables accurate detection of ovarian cancer: an intercontinental, biomarker identification study	7
Noncoding RNA Terc-53 and hyaluronan receptor Hmmr regulate aging in mice	7
Ergothioneine and its congeners: anti-ageing mechanisms and pharmacophore biosynthesis	7
The p15 protein is a promising immunogen for developing protective immunity against African swine fever virus	6
Macrophages suppress cardiac reprogramming of fibroblasts in vivo via IFN-mediated intercellular self-stimulating circuit	6
A minimally invasive, fast on/off “odorgenetic” method to manipulate physiology	6
Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids	6
The chemical reprogramming of unipotent adult germ cells towards authentic pluripotency and de novo establishment of imprinting	6
Precise genome editing without exogenous donor DNA via retron editing system in human cells	6
An engineered xCas12i with high activity, high specificity and broad PAM range	6
Stress granules and organelles: coordinating cellular responses in health and disease	5
Persisting lung pathogenesis and minimum residual virus in hamster after acute COVID-19	5
YME1L overexpression exerts pro-tumorigenic activity in glioma by promoting Gαi1 expression and Akt activation	5
Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques	5
Jiangsen Mao: a pioneer in Chinese hepatitis A vaccine and interferon research, a virologist at the forefront of times	5
Setd2 overexpression rescues bivalent gene expression during SCNT-mediated ZGA	5
Human 8-cell embryos enable efficient induction of disease-preventive mutations without off-target effect by cytosine base editor	5
Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332	5
Maternal heterozygous mutation in CHEK1 leads to mitotic arrest in human zygotes	4
METTL14 is a chromatin regulator independent of its RNA N 6-methyladenosine methyltransferase activity	4
CARM1 drives triple-negative breast cancer progression by coordinating with HIF1A	4
Phosphorylation of NF2 at Serine-13 by MAP4K family kinases mediates pathological angiogenesis	4
APOE-mediated suppression of the lncRNA MEG3 protects human cardiovascular cells from chronic inflammation	4
Correction to: Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling	4
CRL3 E3 ligase regulates glutamine and cystine metabolisms	4
Dual role of lipids for genome stability and pluripotency facilitates full potency of mouse embryonic stem cells	4
Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD	4
Single-cell transcriptomic Atlas of mouse cochlear aging	4
Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice	4
Correction to: Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model	4
IL-24 promotes atopic dermatitis-like inflammation through driving MRSA-induced allergic responses	4
p21/Zbtb18 repress the expression of cKit to regulate the self-renewal of hematopoietic stem cells	4
Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15	4
Skin organoid transplantation promotes tissue repair with scarless in frostbite	4
Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond	4
Correction to: EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation	4
Investigating regional-specific gut microbial distribution: an uncharted territory in disease therapeutics	3
Correction to: A world renowned psychophysiologist: Kaoliang Chow	3
SARS-CoV-2 ORF8 does not function in the nucleus as a histone mimic	3
Molecular architecture of mammalian pyruvate dehydrogenase complex	3
Correction to: ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells	3
Antiviral activity of lipoxygenase against severe fever with thrombocytopenia syndrome virus	3
A CRISPR activation screen identifies genes that enhance SARS-CoV-2 infection	3
Discovery of CCDC188 gene as a novel genetic target for human acephalic spermatozoa syndrome	3
A promising clinical technique to rescue women’s ovarian aging: engineered stem cell-based therapy with the help of AI	3
Emerging roles of RNA N4-acetylcytidine modification in reproductive health	3
cGAS guards against chromosome end-to-end fusions during mitosis and facilitates replicative senescence	3
NDFIP1 limits cellular TAZ accumulation via exosomal sorting to inhibit NSCLC proliferation	3
RADICAL: a rationally designed ion channel activated by ligand for chemogenetics	3
Face off: a metabolic enzyme becomes a protein phosphatase	3
Endothelial-to-Osteoblast Conversion maintains bone homeostasis through Kindlin-2/Piezo1/TGFβ/Runx2 axis	3
Restoration of FMRP expression in adult V1 neurons rescues visual deficits in a mouse model of fragile X syndrome	2
Comprehensive transcriptional atlas of human adenomyosis deciphered by the integration of single-cell RNA-sequencing and spatial transcriptomics	2
Asymmetric reconstruction of the aquareovirus core at near-atomic resolution and mechanism of transcription initiation	2
In memory of the well-renowned Chinese cellular biologist Shien Sher-Pu	2
ORP8 acts as a lipophagy receptor to mediate lipid droplet turnover	2
Ko Kuei Chen: A Pioneer of Modern Pharmacological Research in China	2
Lentivirus-modified hematopoietic stem cell gene therapy for advanced symptomatic juvenile metachromatic leukodystrophy: a long-term follow-up pilot study	2
Targeting IRG1 in tumor-associated macrophages for cancer therapy	2
Zhu Xi: A Pioneer of Experimental Biology	2
The ubiquitin codes in cellular stress responses	2
Genomic instability as a major mechanism for acquired resistance to EGFR tyrosine kinase inhibitors in cancer	2
Professor Delong Su: a pioneer in Schistosomiasis Eradication in China	2