Protein & Cell

Article	Citations
Withdrawn as Duplicate: Remembering the Scholar Ding Ying: The Father of Chinese Rice-Farming Science	299
Gene print-based cell subtypes annotation of human disease across heterogeneous datasets with gPRINT	265
Pan Shuh: the founding figure of modern Chinese psychology	168
DCK confers sensitivity of DCTD-positive cancer cells to oxidized methylcytidines	145
One step, two functions: the mechanism of the ABCH class of transporter serving barrier construction and detoxification in insects	122
Gut microbial methionine impacts circadian clock gene expression and reactive oxygen species level in host gastrointestinal tract	111
JMJD1C forms condensate to facilitate a RUNX1-dependent gene expression program shared by multiple types of AML cells	80
Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging	76
Spatially-resolved expression landscape and gene-regulatory network of human gastric corpus epithelium	66
ARID1A IDR targets EWS-FLI1 condensates and finetunes chromatin remodeling	66
DHA, a potentially therapeutic lipid for myocardial infarction	59
Microbiome research outlook: past, present, and future	59
Architecture of severe fever with thrombocytopenia syndrome virus	50
Endoplasmic reticulum membrane remodeling by targeting reticulon-4 induces pyroptosis to facilitate antitumor immune	50
Anthrax lethal toxin and tumor necrosis factor-α synergize on intestinal epithelia to induce mouse death	49
An improved method for the detection of double-stranded RNA suitable for quality control of mRNA vaccines	48
Dynamin 1-mediated endocytic recycling of glycosylated N-cadherin sustains the plastic mesenchymal state to promote ovarian cancer metastasis	46
Unfolding HBx for an epigenetic switch of HBV cccDNA minichromosome	46
Inheritance and advancement in biochemistry: the pioneering research of Szu-Chih Liu	40
Cryo-EM structures of Nipah virus polymerase complex reveal highly varied interactions between L and P proteins among paramyxoviruses	39
3D chromatin dynamics in cellular neuroendocrine transformation	36
Mutations in the SARS-CoV-2 spike receptor binding domain and their delicate balance between ACE2 affinity and antibody evasion	34
Efficient clustered, regularly interspaced short palindromic repeats-based gene activation using combinatorial human transcription activation domains	33
A single-cell transcriptomic landscape characterizes the endocrine system aging in the mouse	31
NSUN2‑mediated epitranscriptomic and ubiquitin modulation of Nipah virus matrix protein reveals a dual-targeting antiviral strategy	31

A long non-coding RNA LncSync regulates mouse cardiomyocyte homeostasis and cardiac hypertrophy through coordination of miRNA actions	30
Strategies for generating mouse model resources of human disease	30
An orally-available monovalent SMAC mimetic compound as a broad-spectrum antiviral	30
A hnRNPA2B1 agonist effectively inhibits HBV and SARS-CoV-2 omicronin vivo	29
Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2 infection during early pregnancy	29
Restoring the FOXO1 geroprotective pathway via seno-resistant mesenchymal progenitor cells alleviates primate epididymal aging	28
Pasteurized Akkermansia muciniphila promotes GP2 expression in microfold cells and facilitates Salmonella infection	27
Correction to: Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer	27
Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamine	26
Correction to: SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer	26
Long-term in vivo chimeric cells tracking in non-human primate	26
Tuning the Hsp70 chaperone cycle: emerging roles of GrpE-like nucleotide exchange factors in proteostasis and organelle function	26
High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors	24
Primate abnormal spindle-like microcephaly-associated knockout causes severe microcephaly and oligodendrocyte loss in the brain	24
What we can learn from hibernators and other adapted animals about organ transplantation: mechanisms of cold resistance and enhanced regeneration	23
Adenosine-to-inosine RNA editing in cancer: molecular mechanisms and downstream targets	23
Advances in gene and cellular therapeutic approaches for Huntington’s disease	23
Accumulation of newly synthesized docosahexaenoic acid plays an essential role in heart regeneration	23
Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis	22
Microbial sensing in the intestine	21
Radiation injury and gut microbiota-based treatment	21
Tumor cell GPX4 dictates triacylglycerol metabolism for ferroptosis susceptibility and immune evasion of NSCLC	19
Endosomal catabolism of phosphatidylinositol 4,5-bisphosphate is fundamental in building resilience against pathogens	19
Single transmembrane GPCR modulating proteins: neither single nor simple	18
SMURF1: a promising target for colon cancer therapy	17
Hunting out the repeat expansion in Huntington’s pigs	17
Systematicidentification of CRISPR off-target effects by CROss-seq	17
Correction to: Adenosine-to-inosine RNA editing in cancer: molecular mechanisms and downstream targets	17
Secreted proteins in treating metabolic dysfunction-associated steatotic liver disease: from bench towards bedside	16
Glutamine signaling specifically activates c-Myc and Mcl-1 to facilitate cancer cell proliferation and survival	16
The microbiota–gut–brain axis and neurodevelopmental disorders	16
MANF is essential for astrocyte survival in the monkey brain	16
Boundless love: a German Professor Uli Schwarz in China	16
Aberrant outputs of cerebellar nuclei and targeted rescue of social deficits in an autism mouse model	15
Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration	15
Synergistic innovation in organ-on-a-chip and organoid technologies: reshaping the future of disease modeling, drug development, and precision medicine	15
Oncogenic role of the SLC7A13-SLC3A1 cystine transporter in human luminal breast cancer and its cryo-EM structure	14
Systematic characterization of full-length RNA isoforms in human colorectal cancer at single-cell resolution	14
Correction to: DHA, a potentially therapeutic lipid for myocardial infarction	14
Syn3, a newly developed cyclic peptide and BDNF signaling enhancer, ameliorates retinal ganglion cell degeneration in diabetic retinopathy	13
Degeneration Directory: a multi-omics web resource for degenerative diseases	13
Sung Shu Chien: The founder of modern Chinese botany	13
Single-nucleus transcriptomics uncovers a geroprotective role of YAP in primate gingival aging	13
Tanjun Tong: a pioneer of cellular senescence and aging mechanism research in China	13
Human ESC-derived vascular cells promote vascular regeneration in a HIF-1α dependent manner	12
Correction to: Endothelial-to-Osteoblast Conversion maintains bone homeostasis through Kindlin-2/Piezo1/TGFβ/Runx2 axis	12
The chordata olfactory receptor database	12
Structural studies promote vaccine development: lessons from African swine fever virus	12
A molecular brake that modulates spliceosome pausing at detained introns contributes to neurodegeneration	12
Virological research history in China: a century of profiling virologists’ contributions and virological innovations	12

Structural basis of INTAC-regulated transcription	11
Join the club: ORP8 is a lipophagy receptor	11
Cryo-EM structure of human κ-opioid receptor-Gi complex bound to an endogenous agonist dynorphin A	11
Platelet RNA signature independently predicts ovarian cancer prognosis by deep learning neural network model	11
Whole-exome sequencing identifies ECPAS as a novel potentially pathogenic gene in multiple hereditary families with nonsyndromic orofacial cleft	10
Kechun Lin: a pioneer of biophysics explorations in China	10
Bardoxolone methyl blocks the efflux of Zn2+ by targeting hZnT1 to inhibit the proliferation and metastasis of cervical cancer	10
RNA helicase MTR4 drives tumorigenesis of nasopharyngeal carcinoma by regulating the expression of key cell cycle genes	10
Platelet RNA enables accurate detection of ovarian cancer: an intercontinental, biomarker identification study	10
Gut dysbiosis impairs intestinal renewal and lipid absorption in Scarb2 deficiency-associated neurodegeneration	10
The role of parkin in monkey	10
PDHX acetylation facilitates tumor progression by disrupting PDC assembly and activating lactylation-mediated gene expression	9
Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging	9
The chemical reprogramming of unipotent adult germ cells towards authentic pluripotency and de novo establishment of imprinting	9
Ergothioneine and its congeners: anti-ageing mechanisms and pharmacophore biosynthesis	9
Molecular basis of high-torque transmission of the Vibrio polar flagellar motor	9
The unexpected role of RagC in ketogenic diet-derived BHB sensing	9
MMP-9 regulates disulphide isomerase activity of TGM2 to enhance fusion glycoprotein-mediated syncytium formation of respiratory syncytial virus	9
Harnessing human tumor organoids for cancer modeling and precision therapy	8
MultiKano: an automatic cell type annotation tool for single-cell multi-omics data based on Kolmogorov–Arnold network and data augmentation	8
Macrophages suppress cardiac reprogramming of fibroblasts in vivo via IFN-mediated intercellular self-stimulating circuit	8
Genome-wide investigation of transcription factor footprints and dynamics using cFOOT-seq	8
The p15 protein is a promising immunogen for developing protective immunity against African swine fever virus	8
“Sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interaction	8
Noncoding RNA Terc-53 and hyaluronan receptor Hmmr regulate aging in mice	8
BiFC and FACS-based CRISPR screening revealed that QKI promotes PABPN1 LLPS in colorectal cancer cells	8
A minimally invasive, fast on/off “odorgenetic” method to manipulate physiology	8
Optimized derivation and culture system of human naïve pluripotent stem cells with enhanced DNA methylation status and genomic stability	7
An engineered xCas12i with high activity, high specificity and broad PAM range	7
Patient‑specific profiling of TCR‑T cell efficacy enabled by a rapid and standardized reporter system	7
Structural and mechanistic insights into symmetry conversion in plant GORK K+ channel regulation	7
Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids	7
A novel loop-structure-based bispecific CAR that targets CD19 and CD22 with enhanced therapeutic efficacy against B-cell malignancies	7
YME1L overexpression exerts pro-tumorigenic activity in glioma by promoting Gαi1 expression and Akt activation	7
Setd2 overexpression rescues bivalent gene expression during SCNT-mediated ZGA	7
Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques	7
Human meibomian gland organoids to study epithelial homeostasis and dysfunction	7
Advances in multi-omics for esophageal squamous cell carcinoma: diagnostic, prognostic, and therapeutic perspectives	7
CTCF’s loop-independent functions prevail over chromatin looping in the acute degradation system	7
Human embryo editing: Ten years of breakthroughs and challenges	7
Stress granules and organelles: coordinating cellular responses in health and disease	6
Jiangsen Mao: a pioneer in Chinese hepatitis A vaccine and interferon research, a virologist at the forefront of times	6
Specific pathogen free ten gene-edited donor pigs for xenotransplantation	6
Tumor cell intrinsic dsRNA innate immune response triggered by PARP inhibitor is compromised in BRCA1-deficient breast cancer by repressing IRF3	6
Human 8-cell embryos enable efficient induction of disease-preventive mutations without off-target effect by cytosine base editor	6
Lamin C conserves DNA replication factors via phase separation during oxidative stress for DNA replication recovery	6
Phase separation of DUX family proteins drives totipotent-like state via 3D genome reorganization and retrotransposon activation	6
Structural basis for the synaptic adhesion protein ELFN1-mediated modulation of mGlu7	6
Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15	6
Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond	5
Lipid-gated “phosphorylation code” for TCR graded signaling and T-cell exhaustion	5
METTL14 is a chromatin regulator independent of its RNA N 6-methyladenosine methyltransferase activity	5
GA-binding protein alpha ensures proper blastocyst development by suppressing SMAD3-mediated transforming growth factor-beta signaling	5
Dual role of lipids for genome stability and pluripotency facilitates full potency of mouse embryonic stem cells	5
Molecular insights into Candida auris glycosylphosphatidylinositol transamidase	5
Systematic analyses uncover plasma proteins linked to incident cardiovascular diseases	5
p21/Zbtb18 repress the expression of cKit to regulate the self-renewal of hematopoietic stem cells	5
IL-24 promotes atopic dermatitis-like inflammation through driving MRSA-induced allergic responses	5
CRL3 E3 ligase regulates glutamine and cystine metabolisms	5
DNA-triggered AIM2 condensation orchestrates immune activation and regulation	5
APOE-mediated suppression of the lncRNA MEG3 protects human cardiovascular cells from chronic inflammation	4
CARM1 drives triple-negative breast cancer progression by coordinating with HIF1A	4
Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice	4
Face off: a metabolic enzyme becomes a protein phosphatase	4
Pleural cavity macrophages promote lung tumor establishment through tissue invasion	4
Skin organoid transplantation promotes tissue repair with scarless in frostbite	4
Single-cell transcriptomic Atlas of mouse cochlear aging	4
MAAD: multidimensional antiviral antibody database	4
Phosphorylation of NF2 at Serine-13 by MAP4K family kinases mediates pathological angiogenesis	4
A promising clinical technique to rescue women’s ovarian aging: engineered stem cell-based therapy with the help of AI	4
Endosomes as central hubs of interorganellar communication and cellular homeostasis	4
Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD	4
Correction to: EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation	4
EZH2 in non-cancerous diseases: expanding horizons	4
Correction to: Engineered extracellular vesicles enable high-efficient delivery of intracellular therapeutic proteins	4
Structural basis of Arpin homodimerization reveals cooperative inhibition of the Arp2/3 complex through dual-site engagement	4
A CRISPR activation screen identifies genes that enhance SARS-CoV-2 infection	3
rhMG53 induces pharmacological preconditioning by acting as an agonistic ligand of c-met	3
Endothelial-to-Osteoblast Conversion maintains bone homeostasis through Kindlin-2/Piezo1/TGFβ/Runx2 axis	3
Antiviral activity of lipoxygenase against severe fever with thrombocytopenia syndrome virus	3

Investigating regional-specific gut microbial distribution: an uncharted territory in disease therapeutics	3
SARS-CoV-2 ORF8 does not function in the nucleus as a histone mimic	3
NDFIP1 limits cellular TAZ accumulation via exosomal sorting to inhibit NSCLC proliferation	3
ORP8 acts as a lipophagy receptor to mediate lipid droplet turnover	3
Molecular architecture of mammalian pyruvate dehydrogenase complex	3
Correction to: ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells	3
A programmable platform enabling targeted chromosome substitution and cross-species stability profiling	3
Comprehensive transcriptional atlas of human adenomyosis deciphered by the integration of single-cell RNA-sequencing and spatial transcriptomics	3
Discovery of CCDC188 gene as a novel genetic target for human acephalic spermatozoa syndrome	3
Spatiotemporal Ca2+ nanodomain remodeling at MERCS regulates mitochondrial proteostasis	3
Engineering oncolytic bacteria as precision cancer therapeutics: design principles, therapeutic strategies, and translational perspectives	3
RADICAL: a rationally designed ion channel activated by ligand for chemogenetics	3
Emerging roles of RNA N4-acetylcytidine modification in reproductive health	3
Mechanistic insights into the GEF activity of the human MON1A/CCZ1/C18orf8 complex	2
Deciphering the placental abnormalities associated with somatic cell nuclear transfer at single-nucleus resolution	2
Structure-based engineering of the midnolin-proteasome pathway for targeted protein degradation	2
Structural basis of allosteric and bitopic ligands binding in sphingosine-1-phosphate receptors 2 and 3	2
The ubiquitin codes in cellular stress responses	2
Centered on child health: Zhu Futang and the foundations of pediatrics and measles prevention in China	2
Epigenetic Dynamics of Human Spermatogenesis and Their Dysregulation in Non-Obstructive Azoospermia	2
Neutrophil extracellular traps license macrophage production of chemokines to facilitate CD8+ T cell infiltration in obstruction-induced renal fibrosis	2
Professor Delong Su: a pioneer in Schistosomiasis Eradication in China	2
Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation	2
Ko Kuei Chen: A Pioneer of Modern Pharmacological Research in China	2
GlycoRNA research: from unknown unknowns to known unknowns	2
RNA G-quadruplex (rG4) exacerbates cellular senescence by mediating ribosome pausing	2
Targeting IRG1 in tumor-associated macrophages for cancer therapy	2
Correction to: DJ-1 is dispensable for human stem cell homeostasis	2
Periosteal reaction: a natural extracellular matrix barrier to prevent cancer-bone invasion	2
Asymmetric reconstruction of the aquareovirus core at near-atomic resolution and mechanism of transcription initiation	2
Mechanism and design of allosteric activators of SIRT1	2
Zhu Xi: A Pioneer of Experimental Biology	2
Structure, identification, and characterization of the RibD-enolase complex in Francisella	2
In memory of the well-renowned Chinese cellular biologist Shien Sher-Pu	2
Lentivirus-modified hematopoietic stem cell gene therapy for advanced symptomatic juvenile metachromatic leukodystrophy: a long-term follow-up pilot study	2