Science China-Life Sciences

Article	Citations
Metatranscriptomic analysis of host response and vaginal microbiome of patients with severe COVID-19	273
Vibration mechanics involved in buzz pollination lead to size-dependent associations between bumblebees and Pedicularis flowers	226
New insights from a plant immune receptor may help design of disease resistant crops	194
The genetic basis and process of inbreeding depression in an elite hybrid rice	157
RNA ac4C modification in cancer biology: from regulatory mechanisms to clinical applications	141
New loci for refractive errors and ocular biometric parameters in young Chinese Han adults	122
Loss of Tet hydroxymethylase activity causes mouse embryonic stem cell differentiation bias and developmental defects	102
What the genome of the leafy seadragon teaches us about rapid evolution of camouflage and adaptations to life in the kelp forest	99
Pseudo-chromosome—length genome assembly for a deep-sea eel Ilyophis brunneus sheds light on the deep-sea adaptation	92
m6A reader YTHDF2 governs the onset of atrial fibrillation by modulating Cacna1c translation	91
Inhibition of KDM6B prevents osteoarthritis by blocking growth plate-like H3K27me3 loss in bivalent genes	87
Enlarged fins of Tibetan catfish provide new evidence of adaptation to high plateau	85
Unveiling potential sex-determining genes and sex-specific markers in autotetraploid Carassius auratus	80
Convergent and conserved roads lead to Rome: now archaea fill the gap of transcription termination	80
Nanowire-mediated miRNA delivery	74
Cytokines-activated nuclear IKKα-FAT10 pathway induces breast cancer tamoxifen-resistance	68
Dietary carbohydrate intake and risk of type 2 diabetes: a 16-year prospective cohort study	66
Advances in genotypic antimicrobialresistance testing: a comprehensive review	59
Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing	58
Movie therapy for children with amblyopia: restoring binocular vision with brain plasticity	58
Genetic mutations across multiple pathways drive filamentous growth and virulence in the emerging fungal pathogen Candida auris	53
MS1 is essential for male fertility by regulating the microsporocyte cell plate expansion in soybean	50
Microbe-induced gene silencing explores interspecies RNAi and opens up possibilities of crop protection	48
Quantitative characterization of filamentous fungal promoters on a single-cell resolution to discover cryptic natural products	46
Genetically encoded redox biosensor system for H2O2 measurement in four subcellular compartments in acute myeloid leukemia (AML) cells	45

Green manuring relocates microbiomes in driving the soil functionality of nitrogen cycling to obtain preferable grain yields in thirty years	45
Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients	45
Interplant communication: an emerging battlefield in plant-aphid-virus interactions	43
Burch colposuspension for stress urinary incontinence: a 14-year prospective follow-up	42
A shared role of the myocardin-family transcriptional coactivators in cardiomyocyte maturation	41
A neural m6A pathway regulates behavioral aggregation in migratory locusts	40
CRISPR screening identifies protein methylation and ubiquitination modifications that modulate aflatoxin B1 cytotoxicity	40
Mobile ARGONAUTE 1d binds 22-nt miRNAs to generate phasiRNAs important for low-temperature male fertility in rice	39
Dogs lacking Apolipoprotein E show advanced atherosclerosis leading to apparent clinical complications	38
Attenuation of plant immune kinases by U-box type E3 ubiquitin ligases	37
Critical roles of non-coding RNAs in lifecycle and biology of Marek’s disease herpesvirus	37
Predicting Lactobacillus delbrueckii subsp. bulgaricus-Streptococcus thermophilus interactions based on a highly accurate semi-supervised learning method	36
Nitrogen addition promotes soil carbon accumulation globally	36
Human TRMT1 catalyzes m2G or m22G formation on tRNAs in a substrate-dependent manner	36
Precision regulation of plant aromatic amino acid homeostasis	35
Nematode-induced trap formation regulated by the histone H3K4 methyltransferase AoSET1 in the nematode-trapping fungus Arthrobotrys oligospora	35
Cereal-legume intercropping stimulates straw decomposition and promotes soil organic carbon stability	35
NAP-seq: unveiling the hidden world of noncapped RNAs	34
Enlarged DNA unwinding by Nme2Cas9 permits a broadened base editing window beyond the protospacer	34
The genomic and immunogenomic landscape of mechanics pathway informs clinical prognosis and response to mechanotherapy	34
FHL2 deficiency aggravates Candida albicans infection through decreased myelopoiesis	34
Effect of SARS-CoV-2 infection in early pregnancy on placental development	33
Ser68 phosphoregulation is essential for CENP-A deposition, centromere function and viability in mice	33
Plant and fungal species interactions differ between aboveground and belowground habitats in mountain forests of eastern China	33
Advances and applications in single-cell and spatial genomics	32
Integrative analysis based on CRISPR screen identifies apilimod as a potential therapeutic agent for cisplatin-induced acute kidney injury treatment	32
PanSci: decoding panoramas of ageing	32
Low-affinity SPL binding sites contribute to subgenome expression divergence in allohexaploid wheat	30
Ferritin nanocages for early theranostics of tumors via inflammation-enhanced active targeting	30
Ginsenoside Rb1 inhibits oxidative stress-induced ovarian granulosa cell injury through Akt-FoxO1 interaction	30
Priming crops for heat stress with prime editing	29
Animal burrows as critical thermal refuges in the age of climate change	29
Versatile plant genome engineering using anti-CRISPR-Cas12a systems	29
Altered 3D genome reorganization mediates precocious myeloid differentiation of aged hematopoietic stem cells in inflammation	29
Decoding the fish genome opens a new era in important trait research and molecular breeding in China	29
Upgraded durian genome reveals the role of chromosome reshuffling during ancestral karyotype evolution, lignin biosynthesis regulation, and stress tolerance	29
Analysis of non-coding small RNA similarity/sharing between plant and animal genomes	29
One-step base editing in multiple genes by direct embryo injection for pig trait improvement	28
HIV encephalopathy is contributed by macrophages and microglia	28
Enhancing sheepgrass through genomic exploration and targeted editing	28
Explore the nucleolus: unveiling the hidden layer with super-resolution microscopy	27
Piceatannol enhances Beclin-1 activity to suppress tumor progression and its combination therapy strategy with everolimus in gastric cancer	27
Redox state of NAD modulates the activation of Na-bicarbonate cotransporter NBCe1-B via IRBIT and L-IRBIT	26
Studying bona fide SARS-CoV-2 biology in a BSL-2 biosafety environment using a split-virus-genome system	26
Natural polymorphisms of COOL1 contribute to cold tolerance adaptation in maize	26
Chemical defense mediates population density-driven on anuran brain size evolution	26
PIWI-specific insertion module: a newly identified regulatory element essential for longer piRNAs loading and male fertility	25
Erratum to: A thorough analysis of diabetes research in China from 1995 to 2015: current scenario and future scope	25
More abundant and healthier meat: will the MSTN editing epitome empower the commercialization of gene editing in livestock?	25
Thermotolerance in rice	25

Activating translation by phase separation: a novel mechanism for driving spermiogenesis	25
Design of a novel chimeric peptide via dual blockade of CD47/SIRPα and PD-1/PD-L1 for cancer immunotherapy	25
Building the Chordata Olfactory Receptor Database using more than 400,000 receptors annotated by Genome2OR	24
Optimized inner ear organoids for efficient hair cell generation and ototoxicity response modeling	24
Convergent selection of a gene in cereals leads to grain yield upgradation	24
Gene-knockout by iSTOP enables rapid reproductive disease modeling and phenotyping in germ cells of the founder generation	24
Potential oligonucleotide drugs in Bencao sRNA Atlas (II)	24
PDGFR kinase inhibitor protects against septic death via regulation of BTLA	23
Lentiviral vectors for gene therapy of α-thalassemia	23
Coronavirus transmissible gastroenteritis virus antagonizes the antiviral effect of the microRNA miR-27b via the IRE1 pathway	23
A synthetic microbial community used as a bioinoculant can overcome rice production constraints in acid soils	23
Distinct roles of H3K27me3 and H3K36me3 in vernalization response, maintenance, and resetting in winter wheat	22
A hidden translatome in tumors—the coding lncRNAs	22
Targeting LTA4H facilitates the reshaping of the immune microenvironment mediated by CCL5 and sensitizes ovarian cancer to Cisplatin	22
Ancient genomes reveal the genetic inheritance and recent introgression in Chinese indigenous pigs	22
An iron-dependent form of non-canonical ferroptosis induced by labile iron	21
A new model system for cotton indoor genetic and genomic research	21
Green revolution gene drives adaptation of Arabidopsis to the extremely high altitude	21
Surveillance of emerging infectious diseases for biosecurity	21
The discovery of type IV interferon system revolutionizes interferon family and opens up a new frontier in jawed vertebrate immune defense	20
Nitrogen addition and mowing alter drought resistance and recovery of grassland communities	20
LncRNA CFAR promotes cardiac fibrosis via the miR-449a-5p/LOXL3/mTOR axis	20
In-depth urinary and exosome proteome profiling analysis identifies novel biomarkers for diabetic kidney disease	20
Development and performance evaluation of a culture-independent nanopore amplicon-based sequencing method for accurate typing and antimicrobial resistance profiling in Neisseria gonorrhoeae	20
Crop antiviral defense: Past and future perspective	20
Insulin-like growth factor binding proteins 7 prevents dental pulp-derived mesenchymal stem cell senescence via metabolic downregulation of p21	20
Low-dose exposure to microplastics retards meiotic maturation via HDAC3 insufficiency	19
CD146, a therapeutic target involved in cell plasticity	19
Intra-articular injection of stromal vascular fraction for knee degenerative joint disease: a concise review of preclinical and clinical evidence	19
PRC2 primes bivalent genes for transcription induction independent of histone methyltransferase activity	19
Distinct and shared endothermic strategies in the heat producing tissues of tuna and other teleosts	19
The discovery of tiny RNAs that have crucial roles	19
Transient chemical-mediated epigenetic modulation confers unrestricted lineage potential on human primed pluripotent stem cells	19
Identification and validation of key biomarkers and potential therapeutic targets for primary open-angle glaucoma	19
Overcoming genotypic dependency and bypassing immature embryos in wheat transformation by using morphogenic regulators	19
Genomic analysis of modern maize inbred lines reveals diversity and selective breeding effects	19
Genetic advancements and future directions in ruminant livestock breeding: from reference genomes to multiomics innovations	19
Deamidation enables pathogenic SMAD6 variants to activate the BMP signaling pathway	19
CARs: a new approach for the treatment of autoimmune diseases	18
OsRLCK160 contributes to flavonoid accumulation and UV-B tolerance by regulating OsbZIP48 in rice	17
Compound muscle action potential (CMAP) scan examination of paretic and contralateral muscles reveals motor unit alterations after stroke	17
Early changes to the extracellular space in the hippocampus under simulated microgravity conditions	17
The TFIID pivot of preinitiation complex	17
GLA deficiency causes cardiac hypertrophy via enhanced autophagy	17
Plant metabolism paves the way for breeding crops with high nutritional value and stable yield	17
Occurrence and distribution of geminiviruses in China	17
Integrating spatial transcriptomics and single-nucleus RNA-seq revealed the specific inhibitory effects of TGF-β on intramuscular fat deposition	17
When smoke meets gut: deciphering the interactions between tobacco smoking and gut microbiota in disease development	16
Screening and identification of HLA-A2-restricted neoepitopes for immunotherapy of non-microsatellite instability-high colorectal cancer	16
Developing a robust genome editing tool based on an endogenous type I-B CRISPR-Cas system in Saccharopolyspora spinosa	16
Low-dose lactate promotes neuroinflammation and induces the side effect of colitis	16
Nucleolar stress promotes and cooperates with ferroptosis to suppress cancer growth	16
Efficient generation of all ESC-derived mice carrying a homozygous lethal mutation through eight-cell embryo injection	16
Atmospheric humidity regulates same-sex mating in Candida albicans through the trehalose and osmotic signaling pathways	16
Zooming on T cells in cancer	16
Profile of Dr. Shaorong Gao	16
Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retr	16
Decoupled responses of soil microbial diversity and ecosystem functions to successive degeneration processes in alpine pioneer community	16
Innate and adaptive immune abnormalities underlying autoimmune diseases: the genetic connections	16
Advances in regulation and function of stearoyl-CoA desaturase 1 in cancer, from bench to bed	15
A paternal protein facilitates sperm RNA delivery to regulate zygotic development	15
A twist in the tale: global insights into archaeal box C/D RNA-guided 2′-O-methylation	15
Rice GWAS-to-Gene uncovers the polygenic basis of traits	15
Diversity and connectedness of brine shrimp viruses in global hypersaline ecosystems	15
m6A modification of plant virus enables host recognition by NMD factors in plants	15
Autophagy mediates a direct synergistic interaction during co-transmission of two distinct arboviruses by insect vectors	15
Huangjing (Polygonati rhizoma) is an emerging crop with great potential to fight chronic and hidden hunger	15
The effect of SARS-CoV-2 infection on human embryo early development: a multicenter prospective cohort study	15
Mapping and analysis of a spatiotemporal H3K27ac and gene expression spectrum in pigs	15
Wheat stripe rust resistance gene Yr9, derived from rye, is a CC-NBS-LRR gene in a highly conserved NLR cluster	15
Techniques for increasing the yield of stem cell-derived exosomes: what factors may be involved?	15
Single-cell RNA sequencing reveals Nestin+ active neural stem cells outside the central canal after spinal cord injury	15
LPS-related muscle loss is associated with the alteration of Bacteroidetes abundance, systemic inflammation, and mitochondrial morphology in a weaned piglet model	15
Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor	15
The spatial transcriptomic landscape of human gingiva in health and periodontitis	15
Strategic codon selection for enhanced genetic code expansion	14
Cracking the chitin code: how a single pair of LysM receptors deciphers symbiosis and immunity in Marchantia	14
Identification of EPOR and JAK2 double heterozygous variants in twin cases with familial erythrocytosis	14
Enhancing whole yeast genome rearrangements through multiple LoxPsym sequences	14
Loop CD20/CD19 CAR-T cells eradicate B-cell malignancies efficiently	14

G9a/GLP catalyzes H3K14me1 and H3K14me2 in vivo and in vitro	14
Mechanical transmission enables EMT cancer cells to drive epithelial cancer cell migration to guide tumor spheroid disaggregation	14
Harnessing the Streptomyces-originating type I-E CRISPR/Cas system for efficient genome editing in Streptomyces	14
Understanding the “SMART” features of hematopoietic stem cells and beyond	14
Profile of Dr. Jiaojun Zhu	14
Potential oligonucleotide drugs in Bencao sRNA Atlas	14
Individual and joint exposures to PM2.5 constituents and mortality risk among the oldest-old in China	14
Unraveling the origins of PGY-sRNA-6, BZL-sRNA-20, and XKC-sRNA-h3	14
Plant synthetic epigenomic engineering for crop improvement	14
Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2	13
Overview of SARS-CoV-2 genome-encoded proteins	13
SETD3-mediated histidine methylation of MCM7 regulates DNA replication by facilitating chromatin loading of MCM	13
SUB1 promotes colorectal cancer metastasis by activating NF-κB signaling via UBR5-mediated ubiquitination of UBXN1	13
The relative and combined effects of herbivore assemblage and soil nitrogen on plant diversity	13
Treating incurable non-communicable diseases by targeting iron metabolism and ferroptosis	13
Transformation of cognition from mechanical to biological aqueous outflow pump may be a breakthrough in solving the problem of intraocular pressure regulation in glaucoma	13
TIP60 acetylation of Bub1 regulates centromeric H2AT120 phosphorylation for faithful chromosome segregation	13
Yield and quality properties of silage maize and their influencing factors in China	13
Autoinhibition and cofactors of a helper NLR	13
Applications and grants of the National Natural Science Foundation of China’s General Program and Young Scientists Fund in immunology research: a 10-year review (2013–2022)	13
Ultrasound-induced biophysical effects in controlled drug delivery	13
Redox-stress response resistance (RRR) mediated by hyperoxidation of peroxiredoxin 2 in senescent cells	12
Distant cousins come to ABP1’s rescue	12
Global multifaceted biodiversity patterns, centers, and conservation needs in angiosperms	12
Functional characterization of novel NPRL3 mutations identified in three families with focal epilepsy	12
Exploring the R-ISS stage-specific regular networks in the progression of multiple myeloma at single-cell resolution	12
Effector modularity promotes functional diversification and evolutionary processes	12
From oral structure to molecular evidence: new insights into the evolutionary phylogeny of the ciliate order Sessilida (Protista, Ciliophora), with the establishment of two new families and new contri	12
Targeted drug delivery strategies for the treatment of rheumatoid arthritis	12
A novel β2-AR agonist, Higenamine, induces β-arrestin-biased signaling	12
Functional microglia derived from human pluripotent stem cells empower retinal organs	12
Reversing anther thermotolerance by manipulating the cis-elements in the promoter of a high-temperature upregulated gene Casein Kinase I in upland cotton	12
MYC promotes global transcription in part by controlling P-TEFb complex formation via DNA-binding independent inhibition of CDK9 SUMOylation	12
Viromes in marine ecosystems reveal remarkable invertebrate RNA virus diversity	11
Whole grain black rice: a paradigm shift from mainly calories to a nutritious food that benefits human health	11
Prioritization of risk genes in colorectal cancer by integrative analysis of multi-omics data and gene networks	11
Linking circular intronic RNA degradation and function in transcription by RNase H1	11
Cucumber green mottle mosaic virus encodes additional small proteins with specific subcellular localizations and virulence function	11
Crosstalk between brassinosteroid signaling and variable nutrient environments	11
Single-base resolution mapping of 2′-O-methylation sites by an exoribonuclease-enriched chemical method	11
Local field potentials, spiking activity, and receptive fields in human visual cortex	11
Dietary iron regulates intestinal goblet cell function and alleviates Salmonella typhimurium invasion in mice	11
Sequencing and characterizing human mitochondrial genomes in the biobank-based genomic research paradigm	11
Computer-aided engineering of CRISPR-Cas proteins for enhanced human genome editing	11
Recent advances in RNA structurome	11
Structural characterization of SARS-CoV-2 dimeric ORF9b reveals potential fold-switching trigger mechanism	11
Generation of transient totipotent blastomere-like stem cells by short-term high-dose Pladienolide B treatment	10
Amino acids TORC (talk) to anabolism through uncharged tRNA	10
Birth-and-death evolution of ribonuclease 9 genes in Cetartiodactyla	10
An improved hybrid bream derived from a hybrid lineage of Megalobrama amblycephala (♀)×Culter alburnus (♂)	10
The role of corneal endothelium in macular corneal dystrophy development and recurrence	10
Ihog proteins contribute to integrin-mediated focal adhesions	10
The repression of oncoprotein SET by the tumor suppressor p53 reveals a p53-SET-PP2A feedback loop for cancer therapy	10
Promotion of Arabidopsis immune responses by a rhizosphere fungus via supply of pipecolic acid to plants and selective augment of phytoalexins	10
Assessing the ecological effects of the World’s Largest Forestry Eco-engineering: Three-North Protective Forest Program within the initially scheduled range from 1978 to 2022	10
Molecular mechanisms of DNA lesion and repair during antibody somatic hypermutation	10
Recent advances in tissue stem cells	10
Combined effects of climate and land-use changes on the alpha and beta functional diversities of terrestrial mammals in China	10
DDX21 is a new player in co-transcriptional RNA modification and functions	10
Development of regenerative therapies targeting fibrotic endometrium in intrauterine adhesion or thin endometrium to restore uterine function	10
Convergent patterns in multitrophic biodiversity effects on yield across ecosystems	10
Differences in intestinal microbiome are associated with the mortality of COVID-19 patients in intensive care units	10
Truncated glycoprotein E of varicella-zoster virus is an ideal immunogen for Escherichia coli-based vaccine design	10
Base editor-mediated large-scale screening of functional mutations in bacteria for industrial phenotypes	10
A new era of mass data storage in artificial chromosome	10
A widespread response of Gram-negative bacterial acyl-homoserine lactone receptors to Gram-positive Streptomyces γ-butyrolactone signaling molecules	10
Bactericidal bissulfone B7 targets bacterial pyruvate kinase to impair bacterial biology and pathogenicity in plants	10
Extracellular vesicles in cancer progression: mechanisms and significance	10
Genome-wide signatures of the geographic expansion and breeding of soybean	10
The patterns and participants of parental histone recycling during DNA replication in Saccharomyces cerevisiae	10
A comprehensive review on natural phenolic compounds as alternatives to in-feed antibiotics	10
Benyuan Charity Fund-Young Investigator Exploration Award	10
Toll-like receptor signaling in teleosts	9
Identification of antibiotic resistance genes and associated mobile genetic elements in permafrost	9
Unravelling the genetic basis for skeletal muscle mitochondrial DNA copy number variations in pigs	9
Cross-species binding spectrum of ACE2 to SARS-CoV-2 RBD	9
Plant Intron-Splicing Efficiency Database (PISE): exploring splicing of ∼1,650,000 introns in Arabidopsis, maize, rice, and soybean from ∼57,000 public RNA-seq libraries	9
Establishing age-group specific reference intervals of human salivary proteome and its preliminary application for epilepsy diagnosis	9
A field-deployable method for single and multiplex detection of DNA or RNA from pathogens using Cas12 and Cas13	9
Engineering osteoarthritic cartilage model through differentiating senescent human mesenchymal stem cells for testing disease-modifying drugs	9
A urinary proteomic landscape of COVID-19 progression identifies signaling pathways and therapeutic options	9
Current status and challenges of pig-to-human organ xenotransplantation	9
Adult-repopulating lymphoid potential of yolk sac blood vessels is not confined to arterial endothelial cells	9
Progress in immunotherapy	9
Facing small and biased data dilemma in drug discovery with enhanced federated learning approaches	9
Sex-biased adaptation shapes uniparental gene pools in Tibetans	9
Identification of two migratory colon ILC2 populations differentially expressing IL-17A and IL-5/IL-13	9
Two sex pheromone receptors for sexual communication in the American cockroach	9
DEtail-seq is an ultra-efficient and convenient method for meiotic DNA break profiling in multiple organisms	9
SLC39A10 is a key zinc transporter in T cells and its loss mitigates autoimmune disease	9
Pilot work of the 10K Chinese People Genomic Diversity Project along the Silk Road suggests a complex east-west admixture landscape and biological adaptations	9
Embracing the age of artificial intelligence: paradigm shifts, opportunities, and challenges in the treatment of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantatio	9
FishSCT: a zebrafish-centric database for exploration and visualization of fish single-cell transcriptome	9
Role of macrophages in aortic dissection pathogenesis: insights from preclinical studies to translational prospective	9
Exogenous artificial DNA forms chromatin structure with active transcription in yeast	9