Science China-Life Sciences

Article	Citations
Terrestrial carbon sinks in China and around the world and their contribution to carbon neutrality	163
Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases	162
Microglia in depression: current perspectives	130
Emergence and prevalence of naturally occurring lower virulent African swine fever viruses in domestic pigs in China in 2020	113
The landscape of aging	112
Rice functional genomics: decades’ efforts and roads ahead	105
Decreased serum albumin level indicates poor prognosis of COVID-19 patients: hepatic injury analysis from 2,623 hospitalized cases	99
SARS-CoV-2-encoded nucleocapsid protein acts as a viral suppressor of RNA interference in cells	96
Overview of SARS-CoV-2 genome-encoded proteins	91
Non-coding RNAs: the new central dogma of cancer biology	91
Low dose of hydroxychloroquine reduces fatality of critically ill patients with COVID-19	87
Single-cell transcriptome analysis of the novel coronavirus (SARS-CoV-2) associated gene ACE2 expression in normal and non-obstructive azoospermia (NOA) human male testes	81
Punicalagin ameliorates collagen-induced arthritis by downregulating M1 macrophage and pyroptosis via NF-κB signaling pathway	69
Biomarkers of aging	69
The completed macronuclear genome of a model ciliate Tetrahymena thermophila and its application in genome scrambling and copy number analyses	68
Cancer metabolism and tumor microenvironment: fostering each other?	68
Wheat genomic study for genetic improvement of traits in China	63
Biodiversity-based development and evolution: the emerging research systems in model and non-model organisms	60
Nano-bio interactions: the implication of size-dependent biological effects of nanomaterials	59
Sex determination mechanisms and sex control approaches in aquaculture animals	51
Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China	50
Comparative study on virus shedding patterns in nasopharyngeal and fecal specimens of COVID-19 patients	49
Generating broad-spectrum tolerance to ALS-inhibiting herbicides in rice by base editing	48
Emerging role of metabolic reprogramming in tumor immune evasion and immunotherapy	44
Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry	43

Hypoglycemic mechanism of polysaccharide from Cyclocarya paliurus leaves in type 2 diabetic rats by gut microbiota and host metabolism alteration	43
Linking circular intronic RNA degradation and function in transcription by RNase H1	42
Analysis of genetic architecture and favorable allele usage of agronomic traits in a large collection of Chinese rice accessions	39
Diet drives convergent evolution of gut microbiomes in bamboo-eating species	38
Identification of a key G-protein coupled receptor in mediating appressorium formation and fungal virulence against insects	36
Fish TNF and TNF receptors	35
Biochemistry of mammalian ferritins in the regulation of cellular iron homeostasis and oxidative responses	35
MicroRNA negatively regulates NF-κB-mediated immune responses by targeting NOD1 in the teleost fish Miichthys miiuy	34
Cuproptosis: copper-induced regulated cell death	34
Understanding the molecular mechanisms of trade-offs between plant growth and immunity	34
AoATG5 plays pleiotropic roles in vegetative growth, cell nucleus development, conidiation, and virulence in the nematode-trapping fungus Arthrobotrys oligospora	34
RNA therapeutics: updates and future potential	34
Task-related functional magnetic resonance imaging-based neuronavigation for the treatment of depression by individualized repetitive transcranial magnetic stimulation of the visual cortex	33
Photosensitive hydrogels: from structure, mechanisms, design to bioapplications	33
Control of seed size by jasmonate	33
New contributions to the phylogeny of the ciliate class Heterotrichea (Protista, Ciliophora): analyses at family-genus level and new evolutionary hypotheses	33
Long-term clinical observation of patients with acute and chronic complete spinal cord injury after transplantation of NeuroRegen scaffold	32
Transient expression of a TaGRF4-TaGIF1 complex stimulates wheat regeneration and improves genome editing	32
Does the Gonostomum-patterned oral apparatus in hypotrichia carry a phylogenetic signal? Evidence from morphological and molecular data based on extended taxon sampling using three nuclear genes (Cili	32
Blocking of the PD-1/PD-L1 interaction by a novel cyclic peptide inhibitor for cancer immunotherapy	29
LncDACH1 promotes mitochondrial oxidative stress of cardiomyocytes by interacting with sirtuin3 and aggravates diabetic cardiomyopathy	28
Molecular actions of NLR immune receptors in plants and animals	28
Long noncoding RNA AANCR modulates innate antiviral responses by blocking miR-210-dependent MITA downregulation in teleost fish, Miichthys miiuy	28
Global Pharmacopoeia Genome Database is an integrated and mineable genomic database for traditional medicines derived from eight international pharmacopoeias	28
Recent advances toward clinical applications of photoacoustic microscopy: a review	27
Triple-negative breast cancer: new treatment strategies in the era of precision medicine	27
Overexpressed Cyclin D1 and CDK4 proteins are responsible for the resistance to CDK4/6 inhibitor in breast cancer that can be reversed by PI3K/mTOR inhibitors	27
Potential role of Lactobacillus plantarum in colitis induced by dextran sulfate sodium through altering gut microbiota and host metabolism in murine model	26
Upregulation of the PPAR signaling pathway and accumulation of lipids are related to the morphological and structural transformation of the dragon-eye goldfish eye	26
A Hu sheep genome with the first ovine Y chromosome reveal introgression history after sheep domestication	26
Molecular mechanisms of adaptive evolution in wild animals and plants	25
An atlas of CNV maps in cattle, goat and sheep	25
Pandemic threat posed by H3N2 avian influenza virus	25
A comprehensive overview of cotton genomics, biotechnology and molecular biological studies	25
Antibody response and therapy in COVID-19 patients: what can be learned for vaccine development?	25
Redox-dependent regulation of end-binding protein 1 activity by glutathionylation	24
A chromosome-level genome assembly of the wild rice Oryza rufipogon facilitates tracing the origins of Asian cultivated rice	24
Extensive sequence divergence between the reference genomes of Taraxacum kok-saghyz and Taraxacum mongolicum	24
Application of deep learning in genomics	24
SecReT6 update: a comprehensive resource of bacterial Type VI Secretion Systems	24
Tomato yellow leaf curl virus V3 protein traffics along microfilaments to plasmodesmata to promote virus cell-to-cell movement	24
Regain of sex determination system and sexual reproduction ability in a synthetic octoploid male fish	24
Roles of FERONIA-like receptor genes in regulating grain size and quality in rice	23
Extensive profiling of the expressions of tRNAs and tRNA-derived fragments (tRFs) reveals the complexities of tRNA and tRF populations in plants	23
Single-cell RNA sequencing reveals Nestin+ active neural stem cells outside the central canal after spinal cord injury	23
Cancer statistics in Chinese older people, 2022: current burden, time trends, and comparisons with the US, Japan, and the Republic of Korea	23
Efficient and high-fidelity base editor with expanded PAM compatibility for cytidine dinucleotide	23
Global patterns and climatic drivers of above- and belowground net primary productivity in grasslands	23
Fusing T5 exonuclease with Cas9 and Cas12a increases the frequency and size of deletion at target sites	22
Recent advances in RNA structurome	22

Lower abundance of Bacteroides and metabolic dysfunction are highly associated with the post-weaning diarrhea in piglets	22
Viromes in marine ecosystems reveal remarkable invertebrate RNA virus diversity	22
Mapping and analysis of a spatiotemporal H3K27ac and gene expression spectrum in pigs	22
Current status and future perspectives of immunotherapy in bladder cancer treatment	22
PKC-SWI6 signaling regulates asexual development, cell wall integrity, stress response, and lifestyle transition in the nematode-trapping fungus Arthrobotrys oligospora	22
The discovery of type IV interferon system revolutionizes interferon family and opens up a new frontier in jawed vertebrate immune defense	21
NPC1-regulated dynamic of clathrin-coated pits is essential for viral entry	21
CBP-mediated Slug acetylation stabilizes Slug and promotes EMT and migration of breast cancer cells	21
Modulation of evening complex activity enables north-to-south adaptation of soybean	21
Plant multiscale networks: charting plant connectivity by multi-level analysis and imaging techniques	21
Gene editing and its applications in biomedicine	21
Injectable collagen scaffold promotes swine myocardial infarction recovery by long-term local retention of transplanted human umbilical cord mesenchymal stem cells	21
Interactions between commensal bacteria and viral infection: insights for viral disease control in farmed animals	21
Huangjing (Polygonati rhizoma) is an emerging crop with great potential to fight chronic and hidden hunger	21
Pathological matrix stiffness promotes cardiac fibroblast differentiation through the POU2F1 signaling pathway	20
A 5′ tRNA-Ala-derived small RNA regulates anti-fungal defense in plants	20
Magnetoresponsive nanozyme: magnetic stimulation on the nanozyme activity of iron oxide nanoparticles	20
Effectiveness of PD-1/PD-L1 inhibitors in the treatment of lung cancer: Brightness and challenge	20
Alterations in gut microbiota and metabolites associated with altitude-induced cardiac hypertrophy in rats during hypobaric hypoxia challenge	20
Subcutaneous and intramuscular fat transcriptomes show large differences in network organization and associations with adipose traits in pigs	19
Genome-wide signatures of the geographic expansion and breeding of soybean	19
Molecular studies of cellulose synthase supercomplex from cotton fiber reveal its unique biochemical properties	19
Natural product sciences: an integrative approach to the innovations of plant natural products	19
Improving the efficiency of prime editing with epegRNAs and high-temperature treatment in rice	19
New treatment for amblyopia based on rules of synaptic plasticity: a randomized clinical trial	19
Octahedral silver oxide nanoparticles enabling remarkable SERS activity for detecting circulating tumor cells	19
DNA framework-engineered electrochemical biosensors	19
Decline of SARS-CoV-2-specific IgG, IgM and IgA in convalescent COVID-19 patients within 100 days after hospital discharge	19
Selenium deficiency-induced multiple tissue damage with dysregulation of immune and redox homeostasis in broiler chicks under heat stress	19
CREB1 contributes colorectal cancer cell plasticity by regulating lncRNA CCAT1 and NF-κB pathways	19
Expanding Asgard members in the domain of Archaea sheds new light on the origin of eukaryotes	19
On the origin of SARS-CoV-2—The blind watchmaker argument	18
Occurrence and distribution of geminiviruses in China	18
Palmitoylation of MDH2 by ZDHHC18 activates mitochondrial respiration and accelerates ovarian cancer growth	18
Yield and quality properties of silage maize and their influencing factors in China	18
Interactions between central nervous system and peripheral metabolic organs	18
Magnetic resonance imaging for chronic pain: diagnosis, manipulation, and biomarkers	18
Long-term, multidomain analyses to identify the breed and allelic effects in MSTN-edited pigs to overcome lameness and sustainably improve nutritional meat production	18
Emergence of a novel reassortant avian influenza virus (H10N3) in Eastern China with high pathogenicity and respiratory droplet transmissibility to mammals	18
Surrogate production of genome-edited sperm from a different subfamily by spermatogonial stem cell transplantation	18
Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities	18
Modes of genetic adaptations underlying functional innovations in the rumen	17
MS1 is essential for male fertility by regulating the microsporocyte cell plate expansion in soybean	17
Glutamine metabolism in Th17/Treg cell fate: applications in Th17 cell-associated diseases	17
Understanding the proteome encoded by “non-coding RNAs”: new insights into human genome	17
New insights into the transovarial transmission of the symbiont Rickettsia in whiteflies	17
Distinct lung microbial community states in patients with pulmonary tuberculosis	17
Gut microbiota in antiviral strategy from bats to humans: a missing link in COVID-19	16
Lineage tracing reveals the origin of Nestin-positive cells are heterogeneous and rarely from ependymal cells after spinal cord injury	16
Functional microglia derived from human pluripotent stem cells empower retinal organs	16
Short-term exposure to fine particulate matter constituents and mortality: case-crossover evidence from 32 counties in China	16
Abnormal meiosis in fertile and sterile triploid cyprinid fish	16
FoxO directly regulates the expression of TOR/S6K and vitellogenin to modulate the fecundity of the brown planthopper	16
Dynamic carbon-nitrogen coupling under global change	16
Recent advances in lentiviral vectors for gene therapy	16
YTHDF1 promotes NLRP3 translation to induce intestinal epithelial cell inflammatory injury during endotoxic shock	16
A field-deployable method for single and multiplex detection of DNA or RNA from pathogens using Cas12 and Cas13	16
Ferritin nanocages for early theranostics of tumors via inflammation-enhanced active targeting	16
Mechanisms of chromatin-based epigenetic inheritance	16
Facing small and biased data dilemma in drug discovery with enhanced federated learning approaches	15
Fruit and vegetable consumption, cardiovascular disease, and all-cause mortality in China	15
Discovery of potential anti-SARS-CoV-2 drugs based on large-scale screening in vitro and effect evaluation in vivo	15
α-Synuclein aggregation and transmission in Parkinson’s disease: a link to mitochondria and lysosome	15
Establishment of genomic library technology mediated by non-homologous end joining mechanism in Yarrowia lipolytica	15
Finite element analysis of trans-lamina cribrosa pressure difference on optic nerve head biomechanics: the Beijing Intracranial and Intraocular Pressure Study	15
The occurrence order and cross-talk of different tRNA modifications	15
Expanding the scope of genome editing with SpG and SpRY variants in rice	15
Dual recombinases-based genetic lineage tracing for stem cell research with enhanced precision	15
An imputed whole-genome sequence-based GWAS approach pinpoints causal mutations for complex traits in a specific swine population	15
The ER membrane protein complex subunit Emc3 controls angiogenesis via the FZD4/WNT signaling axis	15
CRISPR-Cas adaptive immune systems in Sulfolobales: genetic studies and molecular mechanisms	14
One-step base editing in multiple genes by direct embryo injection for pig trait improvement	14
The fungal endophyte Epichloë gansuensis increases NaCl-tolerance in Achnatherum inebrians through enhancing the activity of plasma membrane H+-ATPase and glucose-6-phosphate dehydrogenase	14
Overview and countermeasures of cancer burden in China	14
The spatial variation of soil bacterial community assembly processes affects the accuracy of source tracking in ten major Chinese cities	14
Comparative phosphoproteomic analysis of BR-defective mutant reveals a key role of GhSK13 in regulating cotton fiber development	14
rtcisE2F promotes the self-renewal and metastasis of liver tumor-initiating cells via N6-methyladenosine-dependent E2F3/E2F6 mRNA stability	14
Construction of chlorogenic acid-containing liposomes with prolonged antitumor immunity based on T cell regulation	14
Enhanced genome editing to ameliorate a genetic metabolic liver disease through co-delivery of adeno-associated virus receptor	14
Current progress in the development of prophylactic and therapeutic vaccines	14

circSVIL regulates bovine myoblast development by inhibiting STAT1 phosphorylation	14
A comprehensive review on natural phenolic compounds as alternatives to in-feed antibiotics	14
High-quality genome assembly of Huazhan and Tianfeng, the parents of an elite rice hybrid Tian-you-hua-zhan	14
From one linear genome to a graph-based pan-genome: a new era for genomics	14
Exogenous artificial DNA forms chromatin structure with active transcription in yeast	13
Arsenic trioxide alleviates acute graft-versus-host disease by modulating macrophage polarization	13
Lipidomic analyses reveal enhanced lipolysis in planthoppers feeding on resistant host plants	13
Ubiquitination modification: critical regulation of IRF family stability and activity	13
Advances in technologies for 3D genomics research	13
Causal gene identification and desirable trait recreation in goldfish	13
LSL1 controls cell death and grain production by stabilizing chloroplast in rice	13
Artemisinin analogue SM934 protects against lupus-associated antiphospholipid syndrome via activation of Nrf2 and its targets	13
CRISPR/Cas9-mediated mutagenesis at microhomologous regions of human mitochondrial genome	13
Gut microbiota bridges dietary nutrients and host immunity	13
Mechanical transmission enables EMT cancer cells to drive epithelial cancer cell migration to guide tumor spheroid disaggregation	13
Lactate anions participate in T cell cytokine production and function	13
Antisense oligonucleotide technology can be used to investigate a circular but not linear RNA-mediated function for its encoded gene locus	13
Adaptive T cell immunotherapy in cancer	13
Mobile ARGONAUTE 1d binds 22-nt miRNAs to generate phasiRNAs important for low-temperature male fertility in rice	13
Ultrasound-induced biophysical effects in controlled drug delivery	13
Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival	12
REGγ drives Lgr5+ stem cells to potentiate radiation induced intestinal regeneration	12
HDAC inhibitors improve CRISPR-mediated HDR editing efficiency in iPSCs	12
Structure of SARS-CoV-2 main protease in the apo state	12
Enlightenment about using TCM constitutions for individualized medicine and construction of Chinese-style precision medicine: research progress with TCM constitutions	12
MAP3K2 augments Th1 cell differentiation via IL-18 to promote T cell-mediated colitis	12
A spike-trimer protein-based tetravalent COVID-19 vaccine elicits enhanced breadth of neutralization against SARS-CoV-2 Omicron subvariants and other variants	12
Aberrant auditory system and its developmental implications for autism	12
Single-cell transcriptomes of peripheral blood cells indicate and elucidate severity of COVID-19	12
Critical thinking on amyloid-beta-targeted therapy: challenges and perspectives	12
Techniques for increasing the yield of stem cell-derived exosomes: what factors may be involved?	12
TGF-β regulation of microRNA miR-497-5p and ocular lens epithelial cell mesenchymal transition	12
Neural circuit control of innate behaviors	12
Recent advances in tissue stem cells	12
The use of SARS-CoV-2-related coronaviruses from bats and pangolins to polarize mutations in SARS-Cov-2	12
Cue-triggered activity replay in human early visual cortex	12
Sodium cantharidinate, a novel anti-pancreatic cancer agent that activates functional p53	11
OsRLCK160 contributes to flavonoid accumulation and UV-B tolerance by regulating OsbZIP48 in rice	11
Association between population migration and epidemic control of Coronavirus disease 2019	11
Sequencing barcode construction and identification methods based on block error-correction codes	11
Design and biosynthesis of functional protein nanostructures	11
CD49a+CD49b+ NK cells induced by viral infection reflect an activated state of conventional NK cells	11
Molecular mechanism of mureidomycin biosynthesis activated by introduction of an exogenous regulatory gene ssaA into Streptomyces roseosporus	11
Raising the production of phloretin by alleviation of by-product of chalcone synthase in the engineered yeast	11
Migrasomes: the knowns, the known unknowns and the unknown unknowns: a personal perspective	11
Profiles of muscular amino acids, fatty acids, and metabolites in Shaziling pigs of different ages and relation to meat quality	11
A new era for evolutionary developmental biology in non-model organisms	11
Characterization of Photorhabdus Virulence Cassette as a causative agent in the emerging pathogen Photorhabdus asymbiotica	11
The effect of SARS-CoV-2 infection on human embryo early development: a multicenter prospective cohort study	11
CSCO breast cancer guideline: precise, economical and oriental	11
LncRNA CFAR promotes cardiac fibrosis via the miR-449a-5p/LOXL3/mTOR axis	11
A urinary proteomic landscape of COVID-19 progression identifies signaling pathways and therapeutic options	11
Designing specific bacterial 16S primers to sequence and quantitate plant endo-bacteriome	11
Low-affinity SPL binding sites contribute to subgenome expression divergence in allohexaploid wheat	11
The resurgent landscape of xenotransplantation of pig organs in nonhuman primates	10
Enabling technology and core theory of synthetic biology	10
A widespread response of Gram-negative bacterial acyl-homoserine lactone receptors to Gram-positive Streptomyces γ-butyrolactone signaling molecules	10
The role and potential application of extracellular vesicles in liver cancer	10
Architectural proteins for the formation and maintenance of the 3D genome	10
TatD DNases of African trypanosomes confer resistance to host neutrophil extracellular traps	10
AFAP1-AS1: a rising star among oncogenic long non-coding RNAs	10
Neural mechanisms of social learning and decision-making	10
The genetic arms race between plant and Xanthomonas: lessons learned from TALE biology	10
Compression loading of osteoclasts attenuated microRNA-146a-5p expression, which promotes angiogenesis by targeting adiponectin	10
Spraying compound probiotics improves growth performance and immunity and modulates gut microbiota and blood metabolites of suckling piglets	10
GenoBaits Soy40K: a highly flexible and low-cost SNP array for soybean studies	10
Gut microbiome alterations and its link to corticosteroid resistance in immune thrombocytopenia	10
HIV-1 viral cores enter the nucleus collectively through the nuclear endocytosis-like pathway	10
ZIKV viral proteins and their roles in virus-host interactions	10
Modelling-based evaluation of the effect of quarantine control by the Chinese government in the coronavirus disease 2019 outbreak	10
Melatonin inhibits Gram-negative pathogens by targeting citrate synthase	10
Association between large artery stenosis, cerebral small vessel disease and risk of ischemic stroke	10
Poly-β-hydroxybutyrate alleviated diarrhea and colitis via Lactobacillus johnsonii biofilm-mediated maturation of sulfomucin	10
Cancer challenges worldwide and in China: preparing for the inevitable	10
Quantification of SARS-CoV-2 antigen levels in the blood of patients with COVID-19	10
LATS1 K751 acetylation blocks activation of Hippo signalling and switches LATS1 from a tumor suppressor to an oncoprotein	10
Integration of rhythmic metabolome and transcriptome provides insights into the transmission of rhythmic fluctuations and temporal diversity of metabolism in rice	10
Vegetable biology and breeding in the genomics era	10