Science China-Life Sciences

Article	Citations
Terrestrial carbon sinks in China and around the world and their contribution to carbon neutrality	204
The landscape of aging	155
Emergence and prevalence of naturally occurring lower virulent African swine fever viruses in domestic pigs in China in 2020	134
Rice functional genomics: decades’ efforts and roads ahead	131
Biomarkers of aging	123
Overview of SARS-CoV-2 genome-encoded proteins	118
Wheat genomic study for genetic improvement of traits in China	90
Punicalagin ameliorates collagen-induced arthritis by downregulating M1 macrophage and pyroptosis via NF-κB signaling pathway	82
Cancer metabolism and tumor microenvironment: fostering each other?	80
Sex determination mechanisms and sex control approaches in aquaculture animals	72
Biodiversity-based development and evolution: the emerging research systems in model and non-model organisms	64
Generating broad-spectrum tolerance to ALS-inhibiting herbicides in rice by base editing	60
Linking circular intronic RNA degradation and function in transcription by RNase H1	57
Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China	54
A comprehensive overview of cotton genomics, biotechnology and molecular biological studies	54
Cancer statistics in Chinese older people, 2022: current burden, time trends, and comparisons with the US, Japan, and the Republic of Korea	53
RNA therapeutics: updates and future potential	53
Cuproptosis: copper-induced regulated cell death	45
Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry	44
Overexpressed Cyclin D1 and CDK4 proteins are responsible for the resistance to CDK4/6 inhibitor in breast cancer that can be reversed by PI3K/mTOR inhibitors	44
Control of seed size by jasmonate	41
Molecular mechanisms of adaptive evolution in wild animals and plants	40
Photosensitive hydrogels: from structure, mechanisms, design to bioapplications	38
Transient expression of a TaGRF4-TaGIF1 complex stimulates wheat regeneration and improves genome editing	38
Overview and countermeasures of cancer burden in China	38

Global Pharmacopoeia Genome Database is an integrated and mineable genomic database for traditional medicines derived from eight international pharmacopoeias	38
Gene editing and its applications in biomedicine	37
Long-term clinical observation of patients with acute and chronic complete spinal cord injury after transplantation of NeuroRegen scaffold	37
AoATG5 plays pleiotropic roles in vegetative growth, cell nucleus development, conidiation, and virulence in the nematode-trapping fungus Arthrobotrys oligospora	35
LncDACH1 promotes mitochondrial oxidative stress of cardiomyocytes by interacting with sirtuin3 and aggravates diabetic cardiomyopathy	34
Gut microbiota bridges dietary nutrients and host immunity	32
Cancer profiles in China and comparisons with the USA: a comprehensive analysis in the incidence, mortality, survival, staging, and attribution to risk factors	31
Extensive sequence divergence between the reference genomes of Taraxacum kok-saghyz and Taraxacum mongolicum	31
SecReT6 update: a comprehensive resource of bacterial Type VI Secretion Systems	31
An atlas of CNV maps in cattle, goat and sheep	31
Selenium deficiency-induced multiple tissue damage with dysregulation of immune and redox homeostasis in broiler chicks under heat stress	31
Upregulation of the PPAR signaling pathway and accumulation of lipids are related to the morphological and structural transformation of the dragon-eye goldfish eye	29
Potential role of Lactobacillus plantarum in colitis induced by dextran sulfate sodium through altering gut microbiota and host metabolism in murine model	29
Magnetoresponsive nanozyme: magnetic stimulation on the nanozyme activity of iron oxide nanoparticles	29
Molecular studies of cellulose synthase supercomplex from cotton fiber reveal its unique biochemical properties	28
Recent advances in RNA structurome	28
Improving the efficiency of prime editing with epegRNAs and high-temperature treatment in rice	27
Genome-wide signatures of the geographic expansion and breeding of soybean	27
Lower abundance of Bacteroides and metabolic dysfunction are highly associated with the post-weaning diarrhea in piglets	27
Antibody response and therapy in COVID-19 patients: what can be learned for vaccine development?	27
Subcutaneous and intramuscular fat transcriptomes show large differences in network organization and associations with adipose traits in pigs	26
Pandemic threat posed by H3N2 avian influenza virus	26
Recent advances in lentiviral vectors for gene therapy	26
The discovery of type IV interferon system revolutionizes interferon family and opens up a new frontier in jawed vertebrate immune defense	26
Tomato yellow leaf curl virus V3 protein traffics along microfilaments to plasmodesmata to promote virus cell-to-cell movement	26
Global patterns and climatic drivers of above- and belowground net primary productivity in grasslands	26
Interactions between central nervous system and peripheral metabolic organs	26
Extensive profiling of the expressions of tRNAs and tRNA-derived fragments (tRFs) reveals the complexities of tRNA and tRF populations in plants	26
PKC-SWI6 signaling regulates asexual development, cell wall integrity, stress response, and lifestyle transition in the nematode-trapping fungus Arthrobotrys oligospora	26
A comprehensive review on natural phenolic compounds as alternatives to in-feed antibiotics	25
Mechanisms of chromatin-based epigenetic inheritance	25
Single-cell RNA sequencing reveals Nestin+ active neural stem cells outside the central canal after spinal cord injury	25
Viromes in marine ecosystems reveal remarkable invertebrate RNA virus diversity	25
A 5′ tRNA-Ala-derived small RNA regulates anti-fungal defense in plants	25
Palmitoylation of MDH2 by ZDHHC18 activates mitochondrial respiration and accelerates ovarian cancer growth	25
Yield and quality properties of silage maize and their influencing factors in China	25
Huangjing (Polygonati rhizoma) is an emerging crop with great potential to fight chronic and hidden hunger	24
NPC1-regulated dynamic of clathrin-coated pits is essential for viral entry	24
A field-deployable method for single and multiplex detection of DNA or RNA from pathogens using Cas12 and Cas13	24
Emergence of a novel reassortant avian influenza virus (H10N3) in Eastern China with high pathogenicity and respiratory droplet transmissibility to mammals	24
Alterations in gut microbiota and metabolites associated with altitude-induced cardiac hypertrophy in rats during hypobaric hypoxia challenge	24
CREB1 contributes colorectal cancer cell plasticity by regulating lncRNA CCAT1 and NF-κB pathways	24
Mapping and analysis of a spatiotemporal H3K27ac and gene expression spectrum in pigs	23
Dynamic carbon-nitrogen coupling under global change	23
Modulation of evening complex activity enables north-to-south adaptation of soybean	23
Expanding Asgard members in the domain of Archaea sheds new light on the origin of eukaryotes	23
Efficient and high-fidelity base editor with expanded PAM compatibility for cytidine dinucleotide	23
Octahedral silver oxide nanoparticles enabling remarkable SERS activity for detecting circulating tumor cells	23
Enabling technology and core theory of synthetic biology	22
Long-term, multidomain analyses to identify the breed and allelic effects in MSTN-edited pigs to overcome lameness and sustainably improve nutritional meat production	22

Interactions between commensal bacteria and viral infection: insights for viral disease control in farmed animals	22
Plant multiscale networks: charting plant connectivity by multi-level analysis and imaging techniques	22
Causal gene identification and desirable trait recreation in goldfish	21
Current progress in the development of prophylactic and therapeutic vaccines	21
Short-term exposure to fine particulate matter constituents and mortality: case-crossover evidence from 32 counties in China	21
YTHDF1 promotes NLRP3 translation to induce intestinal epithelial cell inflammatory injury during endotoxic shock	21
Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis	21
MS1 is essential for male fertility by regulating the microsporocyte cell plate expansion in soybean	21
Magnetic resonance imaging for chronic pain: diagnosis, manipulation, and biomarkers	21
Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities	21
Occurrence and distribution of geminiviruses in China	20
New treatment for amblyopia based on rules of synaptic plasticity: a randomized clinical trial	20
On the origin of SARS-CoV-2—The blind watchmaker argument	19
Fruit and vegetable consumption, cardiovascular disease, and all-cause mortality in China	19
Functional microglia derived from human pluripotent stem cells empower retinal organs	19
Surrogate production of genome-edited sperm from a different subfamily by spermatogonial stem cell transplantation	19
Ferritin nanocages for early theranostics of tumors via inflammation-enhanced active targeting	19
Modes of genetic adaptations underlying functional innovations in the rumen	19
Spraying compound probiotics improves growth performance and immunity and modulates gut microbiota and blood metabolites of suckling piglets	19
A spike-trimer protein-based tetravalent COVID-19 vaccine elicits enhanced breadth of neutralization against SARS-CoV-2 Omicron subvariants and other variants	18
REGγ drives Lgr5+ stem cells to potentiate radiation induced intestinal regeneration	18
High-quality genome assembly of Huazhan and Tianfeng, the parents of an elite rice hybrid Tian-you-hua-zhan	18
Expanding the scope of genome editing with SpG and SpRY variants in rice	18
Lineage tracing reveals the origin of Nestin-positive cells are heterogeneous and rarely from ependymal cells after spinal cord injury	18
The occurrence order and cross-talk of different tRNA modifications	18
OsRLCK160 contributes to flavonoid accumulation and UV-B tolerance by regulating OsbZIP48 in rice	18
One-step base editing in multiple genes by direct embryo injection for pig trait improvement	18
Gut microbiota in antiviral strategy from bats to humans: a missing link in COVID-19	17
Profiles of muscular amino acids, fatty acids, and metabolites in Shaziling pigs of different ages and relation to meat quality	17
Discovery of potential anti-SARS-CoV-2 drugs based on large-scale screening in vitro and effect evaluation in vivo	17
Abnormal meiosis in fertile and sterile triploid cyprinid fish	17
Artemisinin analogue SM934 protects against lupus-associated antiphospholipid syndrome via activation of Nrf2 and its targets	17
Establishment of genomic library technology mediated by non-homologous end joining mechanism in Yarrowia lipolytica	17
Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival	17
LncRNA CFAR promotes cardiac fibrosis via the miR-449a-5p/LOXL3/mTOR axis	17
Low-affinity SPL binding sites contribute to subgenome expression divergence in allohexaploid wheat	17
Facing small and biased data dilemma in drug discovery with enhanced federated learning approaches	16
From oral structure to molecular evidence: new insights into the evolutionary phylogeny of the ciliate order Sessilida (Protista, Ciliophora), with the establishment of two new families and new contri	16
Ultrasound-induced biophysical effects in controlled drug delivery	16
Galectin-3-centered paracrine network mediates cardiac inflammation and fibrosis upon β-adrenergic insult	16
Dual recombinases-based genetic lineage tracing for stem cell research with enhanced precision	16
Mobile ARGONAUTE 1d binds 22-nt miRNAs to generate phasiRNAs important for low-temperature male fertility in rice	16
Gut microbiota bridges the iron homeostasis and host health	16
rtcisE2F promotes the self-renewal and metastasis of liver tumor-initiating cells via N6-methyladenosine-dependent E2F3/E2F6 mRNA stability	16
Mechanical transmission enables EMT cancer cells to drive epithelial cancer cell migration to guide tumor spheroid disaggregation	16
Techniques for increasing the yield of stem cell-derived exosomes: what factors may be involved?	15
Vegetable biology and breeding in the genomics era	15
An imputed whole-genome sequence-based GWAS approach pinpoints causal mutations for complex traits in a specific swine population	15
HDAC inhibitors improve CRISPR-mediated HDR editing efficiency in iPSCs	15
LSL1 controls cell death and grain production by stabilizing chloroplast in rice	15
The effect of SARS-CoV-2 infection on human embryo early development: a multicenter prospective cohort study	15
The ER membrane protein complex subunit Emc3 controls angiogenesis via the FZD4/WNT signaling axis	15
A urinary proteomic landscape of COVID-19 progression identifies signaling pathways and therapeutic options	15
circSVIL regulates bovine myoblast development by inhibiting STAT1 phosphorylation	14
Anuran brain size predicts food availability-driven population density	14
Multi-valent mRNA vaccines against monkeypox enveloped or mature viron surface antigens demonstrate robust immune response and neutralizing activity	14
Migrasomes: the knowns, the known unknowns and the unknown unknowns: a personal perspective	14
Surveillance of emerging infectious diseases for biosecurity	14
Designing specific bacterial 16S primers to sequence and quantitate plant endo-bacteriome	14
CRISPR/Cas9-mediated mutagenesis at microhomologous regions of human mitochondrial genome	14
The spatial variation of soil bacterial community assembly processes affects the accuracy of source tracking in ten major Chinese cities	14
LATS1 K751 acetylation blocks activation of Hippo signalling and switches LATS1 from a tumor suppressor to an oncoprotein	14
Lactate anions participate in T cell cytokine production and function	14
Neural circuit control of innate behaviors	14
Recent advances in tissue stem cells	14
Poly-β-hydroxybutyrate alleviated diarrhea and colitis via Lactobacillus johnsonii biofilm-mediated maturation of sulfomucin	14
A comprehensive analysis of the Bencao (herbal) small RNA Atlas reveals novel RNA therapeutics for treating human diseases	14
Integration of rhythmic metabolome and transcriptome provides insights into the transmission of rhythmic fluctuations and temporal diversity of metabolism in rice	14
A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer	14
Efficient de novo assembly and modification of large DNA fragments	14
Lipidomic analyses reveal enhanced lipolysis in planthoppers feeding on resistant host plants	14
Single-cell-resolution transcriptome map revealed novel genes involved in testicular germ cell progression and somatic cells specification in Chinese tongue sole with sex reversal	13
Ginsenoside Rb1 inhibits oxidative stress-induced ovarian granulosa cell injury through Akt-FoxO1 interaction	13
GenoBaits Soy40K: a highly flexible and low-cost SNP array for soybean studies	13
Characterization of Photorhabdus Virulence Cassette as a causative agent in the emerging pathogen Photorhabdus asymbiotica	13
TatD DNases of African trypanosomes confer resistance to host neutrophil extracellular traps	13
Exogenous artificial DNA forms chromatin structure with active transcription in yeast	13
Cancer challenges worldwide and in China: preparing for the inevitable	13
QNE1 is a key flowering regulator determining the length of the vegetative period in soybean cultivars	13
Molecular mechanism of mureidomycin biosynthesis activated by introduction of an exogenous regulatory gene ssaA into Streptomyces roseosporus	13

Association between large artery stenosis, cerebral small vessel disease and risk of ischemic stroke	13
Enlightenment about using TCM constitutions for individualized medicine and construction of Chinese-style precision medicine: research progress with TCM constitutions	13
The role and potential application of extracellular vesicles in liver cancer	13
Melatonin inhibits Gram-negative pathogens by targeting citrate synthase	12
Compression loading of osteoclasts attenuated microRNA-146a-5p expression, which promotes angiogenesis by targeting adiponectin	12
CRISPR-CasRx knock-in mice for RNA degradation	12
Early changes to the extracellular space in the hippocampus under simulated microgravity conditions	12
Peripheral CD4+ T cell signatures in predicting the responses to anti-PD-1/PD-L1 monotherapy for Chinese advanced non-small cell lung cancer	12
Single-cell transcriptomes of peripheral blood cells indicate and elucidate severity of COVID-19	12
Insulin-like growth factor binding proteins 7 prevents dental pulp-derived mesenchymal stem cell senescence via metabolic downregulation of p21	12
Aberrant auditory system and its developmental implications for autism	12
Translocation of gut microbes to epididymal white adipose tissue drives lipid metabolism disorder under heat stress	12
Continued evolution of the Eurasian avian-like H1N1 swine influenza viruses in China	12
Novel loci and potential mechanisms of major depressive disorder, bipolar disorder, and schizophrenia	11
Nanomedicine targeting ferroptosis to overcome anticancer therapeutic resistance	11
Neural mechanisms of social learning and decision-making	11
Trace metal elements: a bridge between host and intestinal microorganisms	11
Nanosecond pulsed electric fields prime mesenchymal stem cells to peptide ghrelin and enhance chondrogenesis and osteochondral defect repair in vivo	11
Ubiquitin-specific protease 47 regulates intestinal inflammation through deubiquitination of TRAF6 in epithelial cells	11
Design of a novel chimeric peptide via dual blockade of CD47/SIRPα and PD-1/PD-L1 for cancer immunotherapy	11
Circular RNA circCCNB1 inhibits the migration and invasion of nasopharyngeal carcinoma through binding and stabilizing TJP1 mRNA	11
Sodium cantharidinate, a novel anti-pancreatic cancer agent that activates functional p53	11
The urgent need to develop a new grassland map in China: based on the consistency and accuracy of ten land cover products	11
TaMADS29 interacts with TaNF-YB1 to synergistically regulate early grain development in bread wheat	11
Quantification of SARS-CoV-2 antigen levels in the blood of patients with COVID-19	10
Targeted DNA demethylation produces heritable epialleles in rice	10
AFAP1-AS1: a rising star among oncogenic long non-coding RNAs	10
Innate and adaptive immune abnormalities underlying autoimmune diseases: the genetic connections	10
Highly efficient generation of blastocyst-like structures from spliceosomes-repressed mouse totipotent blastomere-like cells	10
High-fat diet impairs gut barrier through intestinal microbiota-derived reactive oxygen species	10
A widespread response of Gram-negative bacterial acyl-homoserine lactone receptors to Gram-positive Streptomyces γ-butyrolactone signaling molecules	10
Critical roles of non-coding RNAs in lifecycle and biology of Marek’s disease herpesvirus	10
Whole-exome sequencing reveals genetic risks of early-onset sporadic dilated cardiomyopathy in the Chinese Han population	10
A third high dose of inactivated COVID-19 vaccine induces higher neutralizing antibodies in humans against the Delta and Omicron variants: a Randomized, Double-Blinded Clinical Trial	10
Fullerene nanoparticles for the treatment of ulcerative colitis	10
CARs: a new approach for the treatment of autoimmune diseases	10
Engineering osteoarthritic cartilage model through differentiating senescent human mesenchymal stem cells for testing disease-modifying drugs	10
Longitudinal single-cell RNA-seq of hESCs-derived retinal organoids	10
Large-scale long terminal repeat insertions produced a significant set of novel transcripts in cotton	10
Plant and fungal species interactions differ between aboveground and belowground habitats in mountain forests of eastern China	10
Single-cell transcriptomics of immune cells in lymph nodes reveals their composition and alterations in functional dynamics during the early stages of bubonic plague	10
Exercise-induced microbial changes in preventing type 2 diabetes	10
Decoding six basic emotions from brain functional connectivity patterns	10
Development of MEMS directed evolution strategy for multiplied throughput and convergent evolution of cytochrome P450 enzymes	10
A novel MYCN-YTHDF1 cascade contributes to retinoblastoma tumor growth by eliciting m6A -dependent activation of multiple oncogenes	10
Homo-harringtonine, highly effective against coronaviruses, is safe in treating COVID-19 by nebulization	10
Dietary iron regulates intestinal goblet cell function and alleviates Salmonella typhimurium invasion in mice	10
Nutrition status of patients with common cancer in China: gap, mission and challenge	9
Precise editing of methylated cytosine in Arabidopsis thaliana using a human APOBEC3Bctd-Cas9 fusion	9
Expression of phenylalanine ammonia lyase as an intracellularly free and extracellularly cell surface-immobilized enzyme on a gut microbe as a live biotherapeutic for phenylketonuria	9
The functional analysis of transiently upregulated miR-101 suggests a “braking” regulatory mechanism during myogenesis	9
Plant synthetic epigenomic engineering for crop improvement	9
m6A modification of plant virus enables host recognition by NMD factors in plants	9
Crosstalk between trace elements and T-cell immunity during early-life health in pigs	9
Calcium-dependent protein kinases CPK21 and CPK23 phosphorylate and activate the iron-regulated transporter IRT1 to regulate iron deficiency in Arabidopsis	9
The PIWI-specific insertion module helps load longer piRNAs for translational activation essential for male fertility	9
An iron-dependent form of non-canonical ferroptosis induced by labile iron	9
Single-base resolution mapping of 2′-O-methylation sites by an exoribonuclease-enriched chemical method	9
An improved hybrid bream derived from a hybrid lineage of Megalobrama amblycephala (♀)×Culter alburnus (♂)	9
A neuropsin-based optogenetic tool for precise control of Gq signaling	9
Making sense of spike D614G in SARS-CoV-2 transmission	9
Genomic insights into versatile lifestyle of three new bacterial candidate phyla	9
Geminivirus satellite-encoded βC1 activates UPR, induces bZIP60 nuclear export, and manipulates the expression of bZIP60 downstream genes to benefit virus infection	9
Screening and identification of HLA-A2-restricted neoepitopes for immunotherapy of non-microsatellite instability-high colorectal cancer	9
Digital Noah’s Ark: last chance to save the endangered species	9
Design of nanozymes for inflammatory bowel disease therapy	9
A critical regulation of Th2 cell responses by RORα in allergic asthma	9
A Malvaceae-specific miRNA targeting the newly duplicated GaZIP1L to regulate Zn2+ ion transporter capacity in cotton ovules	9
Does consciousness overflow cognitive access? Novel insights from the new phenomenon of attribute amnesia	9
Immunopathogenesis and immunomodulatory therapy for myocarditis	9
Conversion therapy of intermediate and advanced hepatocellular carcinoma using superstable homogeneous iodinated formulation technology	9
The relative and combined effects of herbivore assemblage and soil nitrogen on plant diversity	9
Exploring the role of autophagy during early human embryonic development through single-cell transcriptome and methylome analyses	9
Population analysis reveals the roles of DNA methylation in tomato domestication and metabolic diversity	9
Comprehensive analysis of mRNA poly(A) tails by PAIso-seq2	9
Neutrophils in cancer—unresolved questions	9
Proteomics provides individualized options of precision medicine for patients with gastric cancer	9
A switch-on molecular biosensor for detection of caspase-3 and imaging of apoptosis of cells	9
Quorum sensing-based interactions among drugs, microbes, and diseases	9