Science China-Life Sciences

Article	Citations
What the genome of the leafy seadragon teaches us about rapid evolution of camouflage and adaptations to life in the kelp forest	374
New insights from a plant immune receptor may help design of disease resistant crops	356
Nanowire-mediated miRNA delivery	194
Cytokines-activated nuclear IKKα-FAT10 pathway induces breast cancer tamoxifen-resistance	178
Vibration mechanics involved in buzz pollination lead to size-dependent associations between bumblebees and Pedicularis flowers	173
Inhibition of KDM6B prevents osteoarthritis by blocking growth plate-like H3K27me3 loss in bivalent genes	169
Quantitative characterization of filamentous fungal promoters on a single-cell resolution to discover cryptic natural products	145
Danhong Injection targets CaMKII through Dihydrotanshinone I to alleviate cardiomyocyte death and inflammation in viral myocarditis	143
m6A reader YTHDF2 governs the onset of atrial fibrillation by modulating Cacna1c translation	142
RNA ac4C modification in cancer biology: from regulatory mechanisms to clinical applications	142
Unveiling potential sex-determining genes and sex-specific markers in autotetraploid Carassius auratus	113
Convergent and conserved roads lead to Rome: now archaea fill the gap of transcription termination	106
Toward a comprehensive map of Rab-mediated cargo transport to migrasomes	101
Genetic mutations across multiple pathways drive filamentous growth and virulence in the emerging fungal pathogen Candida auris	93
The genetic basis and process of inbreeding depression in an elite hybrid rice	78
Dietary carbohydrate intake and risk of type 2 diabetes: a 16-year prospective cohort study	75
Microbe-induced gene silencing explores interspecies RNAi and opens up possibilities of crop protection	72
A neighboring NLR negatively regulates the wheat broad-spectrum resistance protein encoded by Pm21	69
TRAD: a functional annotation resource for human tandem repeats	69
Enlarged fins of Tibetan catfish provide new evidence of adaptation to high plateau	67
Chemical adaptation: bridging synthetic chemistry with drug development	66
Pseudo-chromosome—length genome assembly for a deep-sea eel Ilyophis brunneus sheds light on the deep-sea adaptation	65
Green manuring relocates microbiomes in driving the soil functionality of nitrogen cycling to obtain preferable grain yields in thirty years	58
Functional noncoding variants within the TBX1 enhancer contribute to tetralogy of Fallot	56
Advances in genotypic antimicrobialresistance testing: a comprehensive review	56

Loss of Tet hydroxymethylase activity causes mouse embryonic stem cell differentiation bias and developmental defects	56
Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing	54
Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients	53
Cross-species comparative transcriptomic analysis of spermatozoa reveals species-specific regulatory networks linked to fertilization-associated genes in cattle, sheep and goats	53
FHL2 deficiency aggravates Candida albicans infection through decreased myelopoiesis	52
Enlarged DNA unwinding by Nme2Cas9 permits a broadened base editing window beyond the protospacer	49
NAP-seq: unveiling the hidden world of noncapped RNAs	48
Unraveling the diversity of bile acid modifications by integrative mass spectrometry approaches	46
PanSci: decoding panoramas of ageing	45
Precision regulation of plant aromatic amino acid homeostasis	45
Secretory NS1’ protein of orthoflavivirus promotes viral transmission to mosquitoes by suppressing the RNAi pathway	44
Integrative analysis based on CRISPR screen identifies apilimod as a potential therapeutic agent for cisplatin-induced acute kidney injury treatment	44
A shared role of the myocardin-family transcriptional coactivators in cardiomyocyte maturation	43
Effect of SARS-CoV-2 infection in early pregnancy on placental development	42
Activating the cGAS-STING pathway in hypoxic microenvironment: blocking ADSL’s ER localization	40
An artificial immune switch system: engineering durable, broad-spectrum disease resistance in plants	40
Nicotinamide prevents anti-PD1 immune checkpoint inhibitor-associated early stages of cardiotoxicity	39
Attenuation of plant immune kinases by U-box type E3 ubiquitin ligases	39
The DNA-binding protein PfAP2-V regulates erythrocyte invasion and pathogenesis of the human malaria parasite Plasmodium falciparum	39
Development of modern medicine 4.0: the impact and enlightenment of the Industrial Revolution	38
Systems metabolic engineering of Phaffia rhodozyma for ultra-high astaxanthin production through multiple strategies	38
Targeting complement and coagulation cascades with Buyang Huanwu Decoction attenuates acute inflammation and enhances neuroprotection in spinal cord injury	37
Multi-kingdom gut microbiota analyses define bacterial-fungal interplay in multiple type 2 diabetes cohorts	36
CRISPR screening identifies protein methylation and ubiquitination modifications that modulate aflatoxin B1 cytotoxicity	36
Mobile ARGONAUTE 1d binds 22-nt miRNAs to generate phasiRNAs important for low-temperature male fertility in rice	35
Cereal-legume intercropping stimulates straw decomposition and promotes soil organic carbon stability	35
Plant and fungal species interactions differ between aboveground and belowground habitats in mountain forests of eastern China	35
Host-microbial co-regulation mediates rumen volatile fatty acid production and utilization in dairy cows	35
A neural m6A pathway regulates behavioral aggregation in migratory locusts	34
Nematode-induced trap formation regulated by the histone H3K4 methyltransferase AoSET1 in the nematode-trapping fungus Arthrobotrys oligospora	34
TEDD 2.0: an advanced temporal gene expression database enabled by in-silico functional analyses for developmental mechanism investigation	34
The genomic and immunogenomic landscape of mechanics pathway informs clinical prognosis and response to mechanotherapy	34
Low-affinity SPL binding sites contribute to subgenome expression divergence in allohexaploid wheat	34
Critical roles of non-coding RNAs in lifecycle and biology of Marek’s disease herpesvirus	33
Interplant communication: an emerging battlefield in plant-aphid-virus interactions	33
Phase separation of a master transcription factor targeted by a natural compound regulates fungal ergosterol homeostasis	33
Human TRMT1 catalyzes m2G or m22G formation on tRNAs in a substrate-dependent manner	32
Predicting Lactobacillus delbrueckii subsp. bulgaricus-Streptococcus thermophilus interactions based on a highly accurate semi-supervised learning method	32
Nitrogen addition promotes soil carbon accumulation globally	32
Advances and applications in single-cell and spatial genomics	32
Multi-omics study reveals a light-dependent regulatory network of flavonoid biosynthesis in lettuce (Lactuca sativa L.)	32
HIV encephalopathy is contributed by macrophages and microglia	31
Protein foundation models: a comprehensive survey	31
Cell-specific gene expression plasticity in response to hypoxia promotes high-altitude adaptive evolution	30
Priming crops for heat stress with prime editing	30
SPHK1 deficiency promotes intestinal homeostasis by ameliorating ER stress-induced gastrointestinal injury during murine graft-versus-host disease	30
Antibody-based targeted protein degradation for membrane and extracellular proteins: emerging strategies and breakthroughs	30
Natural polymorphisms of COOL1 contribute to cold tolerance adaptation in maize	29
The vinculin-β-catenin axis promotes bone formation and repair: an essential prerequisite for the anti-osteoporotic efficacy of sclerostin-neutralizing antibody	29
Animal burrows as critical thermal refuges in the age of climate change	29

Explore the nucleolus: unveiling the hidden layer with super-resolution microscopy	29
Enhancing sheepgrass through genomic exploration and targeted editing	29
Peripheral blood RNA modifications as a novel diagnostic signature for polycystic ovary syndrome	29
WTAP mediated m6A methylation modulates retinal photoreceptor function via facilitating of REEP6, PDE6B and RDH12 translation	28
Redox state of NAD modulates the activation of Na-bicarbonate cotransporter NBCe1-B via IRBIT and L-IRBIT	28
RIVER delivers multimodal gene-directed regulatory interactions across diverse biological contexts with broad application potentials	28
From modeling to therapy: the efficient and precise tools for mitochondrial base editing	28
Strategies and mechanisms for the enhancement of chimeric antigen receptor T-cell functions	28
Analysis of non-coding small RNA similarity/sharing between plant and animal genomes	27
Chemical defense mediates population density-driven on anuran brain size evolution	27
Longitudinal plasma proteomic evidence linking SARS-CoV-2 infection to increased β-amyloid pathology	27
IVSA-based siRNA targeted delivery system as a universal strategy for the treatment of EGFR-positive cancer	27
Piceatannol enhances Beclin-1 activity to suppress tumor progression and its combination therapy strategy with everolimus in gastric cancer	27
Versatile plant genome engineering using anti-CRISPR-Cas12a systems	26
Three-dimensional visualization of tip-vesicles in growing pollen tubes by electron tomography	26
Design of a novel chimeric peptide via dual blockade of CD47/SIRPα and PD-1/PD-L1 for cancer immunotherapy	25
Merbecoviruses exploit APN for entry: expanding the receptor toolkit of betacoronaviruses	25
Potential oligonucleotide drugs in Bencao sRNA Atlas (II)	25
Altered 3D genome reorganization mediates precocious myeloid differentiation of aged hematopoietic stem cells in inflammation	25
Upgraded durian genome reveals the role of chromosome reshuffling during ancestral karyotype evolution, lignin biosynthesis regulation, and stress tolerance	25
RNA modifications: bridging the gap between molecular mechanisms and clinical applications	25
Decoding the fish genome opens a new era in important trait research and molecular breeding in China	25
Erratum to: Local administration of liposomal-based Plekhf1 gene therapy attenuates pulmonary fibrosis by modulating macrophage polarization	24
A new model system for cotton indoor genetic and genomic research	24
A synthetic microbial community used as a bioinoculant can overcome rice production constraints in acid soils	24
Erratum to: A thorough analysis of diabetes research in China from 1995 to 2015: current scenario and future scope	24
PIWI-specific insertion module: a newly identified regulatory element essential for longer piRNAs loading and male fertility	24
Activating translation by phase separation: a novel mechanism for driving spermiogenesis	24
Tree of life and conservation of gymnosperms in China	24
A hidden translatome in tumors—the coding lncRNAs	24
Evolutionarily conserved mucus-mediated nanoplastic bioflocculation in Tetrahymena	24
Crop antiviral defense: Past and future perspective	23
Whole-grain black rice diet rewires the single-cell transcriptomic landscape of age-related ovarian decline in mice	23
PDGFR kinase inhibitor protects against septic death via regulation of BTLA	23
Nitrogen addition and mowing alter drought resistance and recovery of grassland communities	23
Light-at-night exposure drives myopia via melanopsin signalling	23
Hot breath, quick exit: aphids flee mammalian heat via TRPA1	23
Green revolution gene drives adaptation of Arabidopsis to the extremely high altitude	23
A newly identified palmitoylation-related molecular signature acts as predictor and possible therapeutic target of atherosclerosis	23
LncRNA CFAR promotes cardiac fibrosis via the miR-449a-5p/LOXL3/mTOR axis	23
How NSUN2 reshapes tRNA for m5C modification	22
Gut microbiome and postbiotics: bridging the dietary nutrition and feed efficiency in food-producing animals	22
Gene-knockout by iSTOP enables rapid reproductive disease modeling and phenotyping in germ cells of the founder generation	22
In-depth urinary and exosome proteome profiling analysis identifies novel biomarkers for diabetic kidney disease	22
Optimized inner ear organoids for efficient hair cell generation and ototoxicity response modeling	22
Targeting LTA4H facilitates the reshaping of the immune microenvironment mediated by CCL5 and sensitizes ovarian cancer to Cisplatin	22
The OsRqc1-OsVms1 module regulates the temperature threshold in thermo-sensitive genic male-sterile rice lines	22
Distinct roles of H3K27me3 and H3K36me3 in vernalization response, maintenance, and resetting in winter wheat	22
Lentiviral vectors for gene therapy of α-thalassemia	22
An iron-dependent form of non-canonical ferroptosis induced by labile iron	22
Distinct and shared endothermic strategies in the heat producing tissues of tuna and other teleosts	21
Identification and validation of key biomarkers and potential therapeutic targets for primary open-angle glaucoma	21
PRC2 primes bivalent genes for transcription induction independent of histone methyltransferase activity	21
Development and performance evaluation of a culture-independent nanopore amplicon-based sequencing method for accurate typing and antimicrobial resistance profiling in Neisseria gonorrhoeae	21
Genomic analysis of modern maize inbred lines reveals diversity and selective breeding effects	21
Transient chemical-mediated epigenetic modulation confers unrestricted lineage potential on human primed pluripotent stem cells	21
STAT3 suppresses palmitic acid-induced apoptosis and fatty acid oxidation dysfunction in bovine mammary epithelial cells by transcriptionally activating CPT1A	21
CARs: a new approach for the treatment of autoimmune diseases	21
Transfer RNA-derived small RNA-Gly activates the ACPH/GRHL1 axis to facilitate liver cell regeneration in acute-on chronic liver failure	21
Deamidation enables pathogenic SMAD6 variants to activate the BMP signaling pathway	21
Overcoming genotypic dependency and bypassing immature embryos in wheat transformation by using morphogenic regulators	21
Pre-disease State perspective in life & health interdisciplinary research	21
The discovery of tiny RNAs that have crucial roles	20
Multidimensional Zoogeographic regionalization of terrestrial vertebrates in China: decoupling the roles of historical process and contemporary ecological filtering	20
CD146, a therapeutic target involved in cell plasticity	20
ESIRA, a novel framework integrating efficacy and safety for evaluating first-line treatments in advanced hepatocellular carcinoma	20
SETD2 governs the regenerative threshold in the liver by gating STAT5-dependent Cox2 signaling	20
Time-series dynamics and biocontrol potential of postharvest bacteria in litchi microbiota	20
Ribo-seq provides additional evidence for cytoplasm-translated mitochondrial DNA-encoded ORFs	20
Galacto-oligosaccharides enrich galactosidase-encoded rather than all Lachnospiraceae bacteria to redress abnormal gut microbiota and lipid metabolism in pregnancy	20
Low-dose exposure to microplastics retards meiotic maturation via HDAC3 insufficiency	20
Genetic advancements and future directions in ruminant livestock breeding: from reference genomes to multiomics innovations	20
Profile of Dr. Shaorong Gao	19
Innate and adaptive immune abnormalities underlying autoimmune diseases: the genetic connections	19
Multi-omic analysis of the liver-breast axis reveals key hepatic mediators of breast cancer progression	19
The effect of SARS-CoV-2 infection on human embryo early development: a multicenter prospective cohort study	19
LPS-related muscle loss is associated with the alteration of Bacteroidetes abundance, systemic inflammation, and mitochondrial morphology in a weaned piglet model	19
Compound muscle action potential (CMAP) scan examination of paretic and contralateral muscles reveals motor unit alterations after stroke	19
GLA deficiency causes cardiac hypertrophy via enhanced autophagy	19
Low-dose lactate promotes neuroinflammation and induces the side effect of colitis	19

Neural identification of self-emitted vocalizations in the auditory midbrain of behaving bats	19
Autophagy mediates a direct synergistic interaction during co-transmission of two distinct arboviruses by insect vectors	19
Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retr	19
Rice GWAS-to-Gene uncovers the polygenic basis of traits	19
Comprehensive metabolic profiling uncovers early variation and biomarkers of esophageal squamous cell carcinoma	19
Atmospheric humidity regulates same-sex mating in Candida albicans through the trehalose and osmotic signaling pathways	18
Wheat stripe rust resistance gene Yr9, derived from rye, is a CC-NBS-LRR gene in a highly conserved NLR cluster	18
Advances in regulation and function of stearoyl-CoA desaturase 1 in cancer, from bench to bed	18
A new regulatory axis in cross-presentation: MS4A7 licenses cDC1s for effective CD8+ T-cell priming	18
Vesicle-mediated intercellular communication	18
The spatial transcriptomic landscape of human gingiva in health and periodontitis	18
Nucleolar stress promotes and cooperates with ferroptosis to suppress cancer growth	18
Cell-supporting cytoskeletons and phagocytic acquisition of compatible solutes emerge as common strategies for high-salt adaptation in different ciliates	18
Rice OsMKK6-OsMPK4 cascade regulates endosperm cellularization via Polycomb Repressive Complex 2	18
Targeting SYK to alleviate MDSC-driven immunosuppression and augment anti-PD1 efficacy	17
Identification of EPOR and JAK2 double heterozygous variants in twin cases with familial erythrocytosis	17
Integrating spatial transcriptomics and single-nucleus RNA-seq revealed the specific inhibitory effects of TGF-β on intramuscular fat deposition	17
AtLYK4 is the major chitin receptor in Arabidopsis with N-glycosylation and ligand-interacting residues orchestrating chitin perception	17
Multifactorial and multiplexed epigenomic profiling of five DNA modifications in plants with mDIP-seq	17
When smoke meets gut: deciphering the interactions between tobacco smoking and gut microbiota in disease development	17
Diversity and connectedness of brine shrimp viruses in global hypersaline ecosystems	17
m6A modification of plant virus enables host recognition by NMD factors in plants	17
Enhancing whole yeast genome rearrangements through multiple LoxPsym sequences	17
Nitrogen fertilization increases soil organic carbon through distinct pathways in contrasting cropland soils	17
Efficient generation of all ESC-derived mice carrying a homozygous lethal mutation through eight-cell embryo injection	17
Decoupled responses of soil microbial diversity and ecosystem functions to successive degeneration processes in alpine pioneer community	17
A twist in the tale: global insights into archaeal box C/D RNA-guided 2′-O-methylation	17
A paternal protein facilitates sperm RNA delivery to regulate zygotic development	17
Evolution of drug classification, target distribution, and introduction of novel antidepressants in China	17
Developing a robust genome editing tool based on an endogenous type I-B CRISPR-Cas system in Saccharopolyspora spinosa	17
Cracking the chitin code: how a single pair of LysM receptors deciphers symbiosis and immunity in Marchantia	16
Strategic codon selection for enhanced genetic code expansion	16
SUB1 promotes colorectal cancer metastasis by activating NF-κB signaling via UBR5-mediated ubiquitination of UBXN1	16
Mitophagy activation for jawbone radiation injury therapy via angiogenesis/osteogenesis-active nanozymes	16
MtLICK1/2: gatekeepers of symbiosis and immunity in Medicago truncatula	16
Potential oligonucleotide drugs in Bencao sRNA Atlas	16
Enhancement of in vitro transcribed (IVT) mRNA translation efficiency through engineered poly(A) tails	16
Broad synergistic effects of an AMP with multiple antibiotics against drug-resistant bacteria via multifaceted mechanisms	16
Unraveling the origins of PGY-sRNA-6, BZL-sRNA-20, and XKC-sRNA-h3	16
GhDREB1B-GhFAD3-2 module mediates drought tolerance by regulating linolenic acid biosynthesis in cotton	16
Individual and joint exposures to PM2.5 constituents and mortality risk among the oldest-old in China	16
Harnessing the Streptomyces-originating type I-E CRISPR/Cas system for efficient genome editing in Streptomyces	16
Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2	16
Morphological and physiological responses to aridity in narrowly- and widely-distributed plant species in drylands	15
Click-crosslinked nano-hydrogel enables metabolic immune reprogramming for diabetic foot ulcers	15
TIP60 acetylation of Bub1 regulates centromeric H2AT120 phosphorylation for faithful chromosome segregation	15
Effector modularity promotes functional diversification and evolutionary processes	15
Redox-stress response resistance (RRR) mediated by hyperoxidation of peroxiredoxin 2 in senescent cells	15
Profile of Dr. Jiaojun Zhu	15
Synergistic T cell and microbiome dysregulation in FOXP3-mediated immune enteritis: insights from multimodal omics	15
Loop CD20/CD19 CAR-T cells eradicate B-cell malignancies efficiently	15
Functional characterization of novel NPRL3 mutations identified in three families with focal epilepsy	15
Applications and grants of the National Natural Science Foundation of China’s General Program and Young Scientists Fund in immunology research: a 10-year review (2013–2022)	15
ZNF200 and DDX17 regulatory loop promotes tumor growth and metastasis by activating RBPJ transcription in non-small cell lung cancer	15
Single-nucleus RNA sequencing reveals the underlying roadmap of early gonadal differentiation in teleost	15
Autoinhibition and cofactors of a helper NLR	15
The theory of the inflammatory ecosystem	15
MYC promotes global transcription in part by controlling P-TEFb complex formation via DNA-binding independent inhibition of CDK9 SUMOylation	14
Chromatin accessibility landscape during mammalian preimplantation development	14
Erratum to: FSIP1 enhances the therapeutic sensitivity to CDK4/6 inhibitors in triple-negative breast cancer patients by activating the Nanog pathway	14
Crosstalk between brassinosteroid signaling and variable nutrient environments	14
Biosynthesis of melanin from lignin hydrolysates by metabolically engineered Cupriavidus necator	14
Transformation of cognition from mechanical to biological aqueous outflow pump may be a breakthrough in solving the problem of intraocular pressure regulation in glaucoma	14
Deubiquitinases in liver diseases: from mechanisms to targeted therapy	14
Approaching the perfection of natural enzymes: evolution of biomimetic catalytic systems	14
SETD3-mediated histidine methylation of MCM7 regulates DNA replication by facilitating chromatin loading of MCM	14
Computer-aided engineering of CRISPR-Cas proteins for enhanced human genome editing	14
RNA regulation in plants	14
Sequencing and characterizing human mitochondrial genomes in the biobank-based genomic research paradigm	14
Negative edge effects on forest carbon stocks in China: an estimate based on inventory data	14
Microbial bile acid modifications: current understandings, key problems, and future perspectives	14
Progress and gaps in antimicrobial resistance research within One Health sectors in China: a systematic analysis	14
Local field potentials, spiking activity, and receptive fields in human visual cortex	14
Dietary iron regulates intestinal goblet cell function and alleviates Salmonella typhimurium invasion in mice	14
Distant cousins come to ABP1’s rescue	14
Treating incurable non-communicable diseases by targeting iron metabolism and ferroptosis	14
Publisher Correction to: The light and hypoxia induced gene ZmPORB1 determines tocopherol content in the maize kernel	14
Increased virulence and decreased antimicrobial resistance in Klebsiella pneumoniae in Beijing since 2020: a retrospective molecular epidemiology study	14
Reversing anther thermotolerance by manipulating the cis-elements in the promoter of a high-temperature upregulated gene Casein Kinase I in upland cotton	14
Prioritization of risk genes in colorectal cancer by integrative analysis of multi-omics data and gene networks	14
Functional cancer-cell-nociceptive neuronal circuits drive gastric tumor progression	13
Single-nucleus transcriptome profiling of wild boar and domestic pig intestines reveals the spatiotemporal dynamics of immunity and nutrient absorption	13
WNT2/2B double homologous knockout blocks lung development and formation in pigs	13
A strategy for the development of receptor-containing antibodies targeting malaria variant surface antigens	13
From oral structure to molecular evidence: new insights into the evolutionary phylogeny of the ciliate order Sessilida (Protista, Ciliophora), with the establishment of two new families and new contri	13
SNX25-mediated regulation of NGF by Periploca sepium periplosides from Xiangjiapi in macrophage-dependent anti-nociception	13
DDX21 is a new player in co-transcriptional RNA modification and functions	13
Dynamic landscape and regulation of m5C methylation in human tissues	13
Targeting senescent cells in aged adipose tissue induced by ovarian cancer with the NF-κB inhibitor quercetin and resveratrol impedes the growth and metastasis of ovarian cancer	13
Amino acids TORC (talk) to anabolism through uncharged tRNA	13
Engineered CLE peptides promote de novo shoot regeneration in Arabidopsis	13
Automatic quantification, grading and five-year prediction of myopic fundus tessellation: a multi-center, longitudinal deep learning study	13
Bactericidal bissulfone B7 targets bacterial pyruvate kinase to impair bacterial biology and pathogenicity in plants	13
A comprehensive review on natural phenolic compounds as alternatives to in-feed antibiotics	13
Transcriptome-wide identification of glycoRNAs by Clier-seq pipeline	13