Neural Regeneration Research

Article	Citations
Microglia regulation of synaptic plasticity and learning and memory	200
Pathological mechanisms and therapeutic strategies for Alzheimer’s disease	189
Amyloid-beta peptide and tau protein crosstalk in Alzheimer’s disease	113
Astrocytes: a double-edged sword in neurodegenerative diseases	100
Liproxstatin-1 is an effective inhibitor of oligodendrocyte ferroptosis induced by inhibition of glutathione peroxidase 4	99
Oxidative stress factors in Parkinson’s disease	97
Microglia-associated neuroinflammation is a potential therapeutic target for ischemic stroke	92
Microglia in neurodegenerative diseases	78
Promising drug targets and associated therapeutic interventions in Parkinson’s disease	78
Do pyroptosis, apoptosis, and necroptosis (PANoptosis) exist in cerebral ischemia? Evidence from cell and rodent studies	76
Research trends, hot spots and prospects for necroptosis in the field of neuroscience	76
Inflammation in diabetic retinopathy: possible roles in pathogenesis and potential implications for therapy	70
Targeting neuroinflammation in Alzheimer’s disease: from mechanisms to clinical applications	70
Exosomes derived from bone marrow mesenchymal stem cells protect the injured spinal cord by inhibiting pericyte pyroptosis	64
Apelin-13 inhibits apoptosis and excessive autophagy in cerebral ischemia/reperfusion injury	58
The emerging role of probiotics in neurodegenerative diseases: new hope for Parkinson’s disease?	56
Mechanisms of neuroplasticity and brain degeneration: strategies for protection during the aging process	53
Basic mechanisms of peripheral nerve injury and treatment via electrical stimulation	52
Mesenchymal stem cell treatment for peripheral nerve injury: a narrative review	51
Association between inflammatory bowel diseases and Parkinson’s disease: systematic review and meta-analysis	50
Targeting the core of neurodegeneration: FoxO, mTOR, and SIRT1	49
Ferroptosis: a critical player and potential therapeutic target in traumatic brain injury and spinal cord injury	47
Neural stem cell-derived exosome as a nano-sized carrier for BDNF delivery to a rat model of ischemic stroke	45
Lineage tracing of direct astrocyte-to-neuron conversion in the mouse cortex	45
Mitochondrial dysfunctions in neurodegenerative diseases: role in disease pathogenesis, strategies for analysis and therapeutic prospects	45

Inflammation induces zebrafish regeneration	45
Potential effects of mesenchymal stem cell derived extracellular vesicles and exosomal miRNAs in neurological disorders	43
Mechanism underlying treatment of ischemic stroke using acupuncture: transmission and regulation	42
Cortical plasticity and nerve regeneration after peripheral nerve injury	41
The NLRP3 inflammasome: a potential therapeutic target for traumatic brain injury	40
A multi-channel collagen scaffold loaded with neural stem cells for the repair of spinal cord injury	40
The Yin-Yang of osteopontin in nervous system diseases: damage versus repair	39
Oral frailty and neurodegeneration in Alzheimer’s disease	38
SARS-CoV-2 involvement in central nervous system tissue damage	37
Electroacupuncture improves learning and memory functions in a rat cerebral ischemia/reperfusion injury model through PI3K/Akt signaling pathway activation	37
Role of exosomes in the pathogenesis of inflammation in Parkinson’s disease	37
Delving into the recent advancements of spinal cord injury treatment: a review of recent progress	37
Deciphering the role of PGC-1α in neurological disorders: from mitochondrial dysfunction to synaptic failure	36
Application of modern neuroimaging technology in the diagnosis and study of Alzheimer's disease	36
Spinal cord injury-induced cognitive impairment: a narrative review	36
TP53-induced glycolysis and apoptosis regulator alleviates hypoxia/ischemia-induced microglial pyroptosis and ischemic brain damage	36
Therapeutic potential of trehalose in neurodegenerative diseases: the knowns and unknowns	36
Liposome based drug delivery as a potential treatment option for Alzheimer’s disease	36
Interaction between Schwann cells and other cells during repair of peripheral nerve injury	36
Prospects for intelligent rehabilitation techniques to treat motor dysfunction	36
The interaction of stem cells and vascularity in peripheral nerve regeneration	35
The future of retinal gene therapy: evolving from subretinal to intravitreal vector delivery	35
Progress in clinical trials of cell transplantation for the treatment of spinal cord injury: how many questions remain unanswered?	34
Role of vitamin B12 deficiency in ischemic stroke risk and outcome	34
Maraviroc promotes recovery from traumatic brain injury in mice by suppression of neuroinflammation and activation of neurotoxic reactive astrocytes	34
Hyperglycemia in acute ischemic stroke: physiopathological and therapeutic complexity	34
Regulation of neuroimmune processes by damage- and resolution-associated molecular patterns	34
Vimentin as a potential target for diverse nervous system diseases	33
Abnormal characterization of dynamic functional connectivity in Alzheimer’s disease	33
Epidural electrical stimulation for spinal cord injury	33
The relationship between amyloid-beta and brain capillary endothelial cells in Alzheimer’s disease	33
Pro- and anti-epileptic roles of microglia	32
Emerging blood exosome-based biomarkers for preclinical and clinical Alzheimer’s disease: a meta-analysis and systematic review	32
Microglia activation, classification and microglia-mediated neuroinflammatory modulators in subarachnoid hemorrhage	32
Exosomal miR-23b from bone marrow mesenchymal stem cells alleviates oxidative stress and pyroptosis after intracerebral hemorrhage	32
Neuroregeneration and functional recovery after stroke: advancing neural stem cell therapy toward clinical application	32
Parkinson’s disease and diabetes mellitus: common mechanisms and treatment repurposing	32
Survivors of COVID-19 exhibit altered amplitudes of low frequency fluctuation in the brain: a resting-state functional magnetic resonance imaging study at 1-year follow-up	32
Baicalin attenuates blood-spinal cord barrier disruption and apoptosis through PI3K/Akt signaling pathway after spinal cord injury	31
Adipose tissue, systematic inflammation, and neurodegenerative diseases	31
Graphene oxide-composited chitosan scaffold contributes to functional recovery of injured spinal cord in rats	31
Quercetin protects against diabetic retinopathy in rats by inducing heme oxygenase-1 expression	31
Urolithin A alleviates blood-brain barrier disruption and attenuates neuronal apoptosis following traumatic brain injury in mice	31
GDNF to the rescue: GDNF delivery effects on motor neurons and nerves, and muscle re-innervation after peripheral nerve injuries	31
Chronic peripheral inflammation: a possible contributor to neurodegenerative diseases	30
Low-dose lipopolysaccharide as an immune regulator for homeostasis maintenance in the central nervous system through transformation to neuroprotective microglia	30
Physiopathology of ischemic stroke and its modulation using memantine: evidence from preclinical stroke	30
Application of neurotrophic and proangiogenic factors as therapy after peripheral nervous system injury	30
Neutrophil-to-lymphocyte ratio in sporadic amyotrophic lateral sclerosis	29
Potential therapeutic effects of polyphenols in Parkinson's disease: in vivo and in vitro pre-clinical studies	29

Repurposed anti-cancer epidermal growth factor receptor inhibitors: mechanisms of neuroprotective effects in Alzheimer’s disease	29
Insights into stem cell therapy for diabetic retinopathy: a bibliometric and visual analysis	29
Hydrogel-based local drug delivery strategies for spinal cord repair	29
Current application and future directions of photobiomodulation in central nervous diseases	29
Initial failures of anti-tau antibodies in Alzheimer’s disease are reminiscent of the amyloid-β story	29
Efficacy and safety of transcutaneous auricular vagus nerve stimulation combined with conventional rehabilitation training in acute stroke patients: a randomized controlled trial conducted for 1 year	29
Progress in clinical trials of stem cell therapy for cerebral palsy	29
The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline	28
Regulation of neuronal bioenergetics as a therapeutic strategy in neurodegenerative diseases	28
Repetitive transcranial magnetic stimulation for lower extremity motor function in patients with stroke: a systematic review and network meta-analysis	28
Phytochemicals as inhibitors of tumor necrosis factor alpha and neuroinflammatory responses in neurodegenerative diseases	28
Potential neuroprotection by Dendrobium nobile Lindl alkaloid in Alzheimer’s disease models	28
Aquaporin 4 deficiency eliminates the beneficial effects of voluntary exercise in a mouse model of Alzheimer’s disease	28
P2X7 receptor activation aggravates NADPH oxidase 2-induced oxidative stress after intracerebral hemorrhage	28
Vicious cycle of lipid peroxidation and iron accumulation in neurodegeneration	28
Retinal regeneration requires dynamic Notch signaling	28
Diabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy	27
Astrocytes protect dopaminergic neurons against aminochrome neurotoxicity	27
Exosomes derived from bone marrow mesenchymal stem cells inhibit neuroinflammation after traumatic brain injury	27
LncRNA Airsci increases the inflammatory response after spinal cord injury in rats through the nuclear factor kappa B signaling pathway	27
Corneal neuromediator profiles following laser refractive surgery	27
PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons	27
Analysis of corneal nerve plexus in corneal confocal microscopy images	26
Ultrasonic vocalizations in mice: relevance for ethologic and neurodevelopmental disorders studies	26
Lithium beyond psychiatric indications: the reincarnation of a new old drug	26
Motor tract reorganization after acute central nervous system injury: a translational perspective	26
Enriched environment boosts the post-stroke recovery of neurological function by promoting autophagy	26
Neuronal reprogramming in treating spinal cord injury	25
DL-3-n-butylphthalide alleviates motor disturbance by suppressing ferroptosis in a rat model of Parkinson’s disease	25
Brain-derived neurotrophic factor and its related enzymes and receptors play important roles after hypoxic-ischemic brain damage	25
The secretome of endothelial progenitor cells: a potential therapeutic strategy for ischemic stroke	25
Bone marrow mesenchymal stem cells and exercise restore motor function following spinal cord injury by activating PI3K/AKT/mTOR pathway	25
Axonal regeneration and sprouting as a potential therapeutic target for nervous system disorders	25
Amyloid-beta and tau protein beyond Alzheimer’s disease	25
Inhibition of LncRNA Vof-16 expression promotes nerve regeneration and functional recovery after spinal cord injury	25
Circulating extracellular vesicles: friends and foes in neurodegeneration	25
Hypoxia in Alzheimer's disease: effects of hypoxia inducible factors	25
Phosphorylated tau as a toxic agent in synaptic mitochondria: implications in aging and Alzheimer’s disease	25
Neuroinflammation as a mechanism linking hypertension with the increased risk of Alzheimer’s disease	24
Advantages of Rho-associated kinases and their inhibitor fasudil for the treatment of neurodegenerative diseases	24
Neuroimaging mechanisms of high-frequency repetitive transcranial magnetic stimulation for treatment of amnestic mild cognitive impairment: a double-blind randomized sham-controlled trial	24
Inflammation and retinal degenerative diseases	24
Rapid GFAP and Iba1 expression changes in the female rat brain following spinal cord injury	24
Glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide dual receptor agonist DA-CH5 is superior to exendin-4 in protecting neurons in the 6-hydroxydopamine rat Parkinson model	24
Degenerative and regenerative processes in amyotrophic lateral sclerosis: motor reserve, adaptation and putative compensatory changes	24
Diabetes mellitus and Parkinson’s disease: dangerous liaisons between insulin and dopamine	23
Microglial depletion impairs glial scar formation and aggravates inflammation partly by inhibiting STAT3 phosphorylation in astrocytes after spinal cord injury	23
Cognitive impairment in multiple sclerosis: lessons from cerebrospinal fluid biomarkers	23
Alterations in gut microbiota are related to metabolite profiles in spinal cord injury	23
The use of hydrogel-delivered extracellular vesicles in recovery of motor function in stroke: a testable experimental hypothesis for clinical translation including behavioral and neuroimaging assessme	23
Neuroprotective effects of naturally sourced bioactive polysaccharides: an update	23
Lycium barbarum polysaccharide-glycoprotein preventative treatment ameliorates aversive	23
Altered microRNA expression in animal models of Huntington’s disease and potential therapeutic strategies	23
Exploration of the mechanism by which icariin modulates hippocampal neurogenesis in a rat model of depression	22
VX-765 reduces neuroinflammation after spinal cord injury in mice	22
Electroacupuncture treatment improves motor function and neurological outcomes after cerebral ischemia/reperfusion injury	22
Stress increases MHC-I expression in dopaminergic neurons and induces autoimmune activation in Parkinson's disease	22
Efficacy of Lycium barbarum polysaccharide in adolescents with subthreshold depression: interim analysis of a randomized controlled study	22
Down-regulating Circular RNA Prkcsh suppresses the inflammatory response after spinal cord injury	22
Exosomes derived from human induced pluripotent stem cell-derived neural progenitor cells protect neuronal function under ischemic conditions	22
Collagen/heparan sulfate porous scaffolds loaded with neural stem cells improve neurological function in a rat model of traumatic brain injury	22
SOCS1/JAK2/STAT3 axis regulates early brain injury induced by subarachnoid hemorrhage via inflammatory responses	22
Role of apoptosis-inducing factor in perinatal hypoxic-ischemic brain injury	22
Acupuncture enhances brain function in patients with mild cognitive impairment: evidence from a functional-near infrared spectroscopy study	21
The Alzheimer’s disease-associated gene TREML2 modulates inflammation by regulating microglia polarization and NLRP3 inflammasome activation	21
Dental pulp stem cells stimulate neuronal differentiation of PC12 cells	21
From cradle to grave: neurogenesis, neuroregeneration and neurodegeneration in Alzheimer’s and Parkinson’s diseases	21
Withaferin A inhibits ferroptosis and protects against intracerebral hemorrhage	21
Rutin pretreatment promotes microglial M1 to M2 phenotype polarization	21
Nerve bundle formation during the promotion of peripheral nerve regeneration: collagen VI-neural cell adhesion molecule 1 interaction	21
Calorie restriction or dietary restriction: how far they can protect the brain against neurodegenerative diseases?	21
A hyaluronic acid granular hydrogel nerve guidance conduit promotes regeneration and functional recovery of injured sciatic nerves in rats	21
Interleukin-4 promotes microglial polarization toward a neuroprotective phenotype after retinal ischemia/reperfusion injury	21
Long-noncoding RNAs as epigenetic regulators in neurodegenerative diseases	21
The “mitochondrial stress responses”: the “Dr. Jekyll and Mr. Hyde” of neuronal disorders	21
Topical delivery of nerve growth factor for treatment of ocular and brain disorders	21
Neuron-fibrous scaffold interfaces in the peripheral nervous system: a perspective on the structural requirements	21
Inhibition of microRNA-29b suppresses oxidative stress and reduces apoptosis in ischemic stroke	21
Gut-microbiome-brain axis: the crosstalk between the vagus nerve, alpha-synuclein and the brain in Parkinson’s disease	20
Connexin therapeutics: blocking connexin hemichannel pores is distinct from blocking pannexin channels or gap junctions	20

In vivo astrocyte-to-neuron reprogramming for central nervous system regeneration: a narrative review	20
Icariin ameliorates memory deficits through regulating brain insulin signaling and glucose transporters in 3×Tg-AD mice	20
Lithium promotes recovery after spinal cord injury	20
Oxidative stress battles neuronal Bcl-xL in a fight to the death	20
One ring is sufficient to inhibit α-synuclein aggregation	20
Toward three-dimensional in vitro models to study neurovascular unit functions in health and disease	20
Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s disease	20
Temporal changes in inflammatory mitochondria-enriched microRNAs following traumatic brain injury and effects of miR-146a nanoparticle delivery	20
Reduced graphene oxide-embedded nerve conduits loaded with bone marrow mesenchymal stem cell-derived extracellular vesicles promote peripheral nerve regeneration	20
Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease: two triggers, one disease	19
P2X4 receptor participates in autophagy regulation in Parkinson's disease	19
Promoting axon regeneration in the central nervous system by increasing PI3-kinase signaling	19
Cdk5 and aberrant cell cycle activation at the core of neurodegeneration	19
Argon reduces microglial activation and inflammatory cytokine expression in retinal ischemia/reperfusion injury	19
Bioinformatics analysis of ferroptosis in spinal cord injury	19
Cathepsins in neuronal plasticity	19
Stellate ganglion block reduces inflammation and improves neurological function in diabetic rats during ischemic stroke	19
The role of peptidase neurolysin in neuroprotection and neural repair after stroke	19
Transcranial magnetic stimulation in animal models of neurodegeneration	19
Spastin interacts with collapsin response mediator protein 3 to regulate neurite growth and branching	19
The neurosphere assay: an effective in vitro technique to study neural stem cells	19
M1-type microglia can induce astrocytes to deposit chondroitin sulfate proteoglycan after spinal cord injury	19
Machine learning applications in stroke medicine: advancements, challenges, and future prospectives	19
TLR2 and TLR4-mediated inflammation in Alzheimer’s disease: self-defense or sabotage?	19
MicroRNAs as biomarkers in glaucoma and potential therapeutic targets	19
Hippo signaling: bridging the gap between cancer and neurodegenerative disorders	18
Solid lipid nanoparticles loading with curcumin and dexanabinol to treat major depressive disorder	18
Construction and imaging of a neurovascular unit model	18
Cerebellar pathology in motor neuron disease: neuroplasticity and neurodegeneration	18
Therapeutic potential of dental pulp stem cell transplantation in a rat model of Alzheimer’s disease	18
Functional repertoire of protein kinases and phosphatases in synaptic plasticity and associated neurological disorders	18
Production of chitosan scaffolds by lyophilization or electrospinning: which is better for peripheral nerve regeneration?	18
Erythropoietin inhibits ferroptosis and ameliorates neurological function after spinal cord injury	18
The lymphatic drainage systems in the brain: a novel target for ischemic stroke?	18
The mechanisms through which auricular vagus nerve stimulation protects against cerebral ischemia/reperfusion injury	18
Pannexin 1, a large-pore membrane channel, contributes to hypotonicity-induced ATP release in Schwann cells	18
Oligodendrocyte pathology in fetal alcohol spectrum disorders	18
Current application of neurofilaments in amyotrophic lateral sclerosis and future perspectives	18
Hydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer’s disease through reducing neuroinflammation and modulating intestinal microbiota	18
Pentadecapeptide BPC 157 and the central nervous system	18
Melatonin, tunneling nanotubes, mesenchymal cells, and tissue regeneration	18
Angiogenesis and nerve regeneration induced by local administration of plasmid pBud-coVEGF165-coFGF2 into the intact rat sciatic nerve	18
Oligodendrocyte precursor cell maturation: role of adenosine receptors	18
Axonal remodeling of the corticospinal tract during neurological recovery after stroke	18
Neural regeneration research model to be explored: SH-SY5Y human neuroblastoma cells	18
Delayed atomoxetine or fluoxetine treatment coupled with limited voluntary running promotes motor recovery in mice after ischemic stroke	18
Oxidative stress in retinal pigment epithelium degeneration: from pathogenesis to therapeutic targets in dry age-related macular degeneration	18
Role of circular RNA expression in the pathological progression after spinal cord injury	18
Evaluation of the combined activity of benzimidazole arylhydrazones as new anti-Parkinsonian agents: monoamine oxidase-B inhibition, neuroprotection and oxidative stress modulation	18
Neuroimmune connections between corticotropin-releasing hormone and mast cells: novel strategies for the treatment of neurodegenerative diseases	17
MicroRNAs as diagnostic and prognostic biomarkers of age-related macular degeneration: advances and limitations	17
Pramipexole, a dopamine D3/D2 receptor-preferring agonist, attenuates reserpine-induced fibromyalgia-like model in mice	17
Molecular mechanisms underlying the neuroprotection of environmental enrichment in Parkinson’s disease	17
Alerting effects of light in healthy individuals: a systematic review and meta-analysis	17
Diabetic retinopathy: neurovascular disease requiring neuroprotective and regenerative therapies	17
Arbutin effectively ameliorates the symptoms of Parkinson’s disease: the role of adenosine receptors and cyclic adenosine monophosphate	17
Significance of mitochondrial activity in neurogenesis and neurodegenerative diseases	17
Stem cell therapy in retinal diseases	17
Ruxolitinib attenuates secondary injury after traumatic spinal cord injury	17
MicroRNA and mRNA profiling of cerebral cortex in a transgenic mouse model of Alzheimer’s disease by RNA sequencing	17
The gut microbiome: implications for neurogenesis and neurological diseases	17
Sex-biased autophagy as a potential mechanism mediating sex differences in ischemic stroke outcome	17
Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence	17
Anxiety, depression, and quality of life in Parkinson’s disease: the implications of multidisciplinary treatment	17
The mechanism behind activation of the Nod-like receptor family protein 3 inflammasome in Parkinson’s disease	17
The plasminogen activating system in the pathogenesis of Alzheimer’s disease	17
Exogenous platelet-derived growth factor improves neurovascular unit recovery after spinal cord injury	17
Ascorbic acid accelerates Wallerian degeneration after peripheral nerve injury	17
Agomelatine: a potential novel approach for the treatment of memory disorder in neurodegenerative disease	17
Melatonin, circadian rhythms and glaucoma: current perspective	17
Advance in the use of gold nanoparticles in the treatment of neurodegenerative diseases: new perspectives	17
Promise of metformin for preventing age-related cognitive dysfunction	17
Microglial activation and adult neurogenesis after brain stroke	16
Brain-derived neurotrophic factor protects against acrylamide-induced neuronal and synaptic injury via the TrkB-MAPK-Erk1/2 pathway	16
From regenerative strategies to pharmacological approaches: can we fine-tune treatment for Parkinson’s disease?	16
Overexpressing NeuroD1 reprograms Müller cells into various types of retinal neurons	16
Neuroglobin and neuroprotection: the role of natural and synthetic compounds in neuroglobin pharmacological induction	16
miR-103-3p targets Ndel1 to regulate neural stem cell proliferation and differentiation	16
Brain delivering RNA-based therapeutic strategies by targeting mTOR pathway for axon regeneration after central nervous system injury	16
Sustained release of exosomes loaded into polydopamine-modified chitin conduits promotes peripheral nerve regeneration in rats	16
Chitin scaffold combined with autologous small nerve repairs sciatic nerve defects	16
Intranasal insulin ameliorates neurological impairment after intracerebral hemorrhage in mice	16
Probiotics, prebiotics and their role in Alzheimer’s disease	16
Astrocyte polarization in glaucoma: a new opportunity	16
Apolipoprotein A1, the neglected relative of Apolipoprotein E and its potential role in Alzheimer’s disease	16
The role of NLRP3 inflammasome for microglial response to peripheral inflammation	16
CircLphn3 protects the blood-brain barrier in traumatic brain injury	16
Molecular approaches for spinal cord injury treatment	16
Mens sana in corpore sano: lifestyle changes modify astrocytes to contain Alzheimer’s disease	16
Olfactory ensheathing cell transplantation alters the expression of chondroitin sulfate proteoglycans and promotes axonal regeneration after spinal cord injury	16
Role of microtubule dynamics in Wallerian degeneration and nerve regeneration after peripheral nerve injury	16
Alzheimer’s disease: a tale of two diseases?	16
Involvement of NLRP3-inflammasome pathway in noise-induced hearing loss	16
Mitochondrial inorganic polyphosphate (polyP): the missing link of mammalian bioenergetics	16
Non-coding RNAs and other determinants of neuroinflammation and endothelial dysfunction: regulation of gene expression in the acute phase of ischemic stroke and possible therapeutic applications	16