OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Zhejiang University-Science B is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
CRISPR/Cas: a Nobel Prize award-winning precise genome editing technology for gene therapy and crop improvement	108
Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses	91
Research advances in bioactive components and health benefits of jujube (Ziziphus jujuba Mill.) fruit	63
Comparison of COVID-19 and influenza characteristics	43
A novel anticancer property of Lycium barbarum polysaccharide in triggering ferroptosis of breast cancer cells	34
Proteomic characterization of four subtypes of M2 macrophages derived from human THP-1 cells	33
Iron metabolism, ferroptosis, and lncRNA in cancer: knowns and unknowns	27
Autophagy and cancer treatment: four functional forms of autophagy and their therapeutic applications	25
Hydrogen agronomy: research progress and prospects	24
MRN complex is an essential effector of DNA damage repair	24
Effects of nanofibers on mesenchymal stem cells: environmental factors affecting cell adhesion and osteogenic differentiation and their mechanisms	24
Spirulina platensis aqueous extracts ameliorate colonic mucosal damage and modulate gut microbiota disorder in mice with ulcerative colitis by inhibiting inflammation and oxidative stress	22
Modification of polyetheretherketone (PEEK) physical features to improve osteointegration	21
Roles of neutrophil reactive oxygen species (ROS) generation in organ function impairment in sepsis	20
Hypoxia-induced ROS aggravate tumor progression through HIF-1α-SERPINE1 signaling in glioblastoma	20
Biocompatible chitosan/polyethylene glycol/multi-walled carbon nanotube composite scaffolds for neural tissue engineering	20
Index of microcirculatory resistance: state-of-the-art and potential applications in computational simulation of coronary artery disease	20
Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options	19
Screening beneficial bacteriostatic lactic acid bacteria in the intestine and studies of bacteriostatic substances	19
Target binding and residence: a new determinant of DNA double-strand break repair pathway choice in CRISPR/Cas9 genome editing	19
DNA alkylation lesion repair: outcomes and implications in cancer chemotherapy	18
Hydroxychavicol, a polyphenol from Piper betle leaf extract, induces cell cycle arrest and apoptosis in TP53-resistant HT-29 colon cancer cells	18
Regulation of DNA double-strand break repair pathway choice: a new focus on 53BP1	17
High expression of FABP4 in colorectal cancer and its clinical significance	17
A comprehensive update: gastrointestinal microflora, gastric cancer and gastric premalignant condition, and intervention by traditional Chinese medicine	17

Scutellarin prevents acute alcohol-induced liver injury via inhibiting oxidative stress by regulating the Nrf2/HO-1 pathway and inhibiting inflammation by regulating the AKT, p38 MAPK/NF-κB pathways	17
Efficient genetic transformation and CRISPR/Cas9-mediated genome editing of watermelon assisted by genes encoding developmental regulators	17
Detection of human papillomavirus in oropharyngeal squamous cell carcinoma	16
Integrative analysis of prognostic long non-coding RNAs with copy number variation in bladder cancer	16
Molecular hydrogen is a promising therapeutic agent for pulmonary disease	16
Role of deubiquitinating enzymes in DNA double-strand break repair	15
Changes in the gut microbiota of osteoporosis patients based on 16S rRNA gene sequencing: a systematic review and meta-analysis	15
Relapse after CAR-T cell therapy in B-cell malignancies: challenges and future approaches	15
Electromagnetic field exposure as a plausible approach to enhance the proliferation and differentiation of mesenchymal stem cells in clinically relevant scenarios	14
Chemical characterization of a new sulfated polysaccharide from Gracilaria chouae and its activation effects on RAW264.7 macrophages	14
Research and application advances in rehabilitation assessment of stroke	14
Protective effect of recombinant Lactobacillus plantarum against H2O2-induced oxidative stress in HUVEC cells	14
How silicon fertilizer improves nitrogen and phosphorus nutrient availability in paddy soil?	14
Low-intensity pulsed ultrasound ameliorates angiotensin II-induced cardiac fibrosis by alleviating inflammation via a caveolin-1-dependent pathway	14
Primary duct closure versus T-tube drainage after laparoscopic common bile duct exploration: a meta-analysis	13
Applications of smartphone-based near-infrared (NIR) imaging, measurement, and spectroscopy technologies to point-of-care (POC) diagnostics	13
A proteomic analysis of Bcl-2 regulation of cell cycle arrest: insight into the mechanisms	13
Chemerin promotes proliferation and migration of ovarian cancer cells by upregulating expression of PD-L1	13
Traditional Chinese medicines and their active ingredients sensitize cancer cells to TRAIL-induced apoptosis	12
Tumor-associated macrophages in osteosarcoma	12
HDAC inhibitor chidamide synergizes with venetoclax to inhibit the growth of diffuse large B-cell lymphoma via down-regulation of MYC, BCL2, and TP53 expression	11
Inhibitory mechanism of angiotensin-converting enzyme inhibitory peptides from black tea	11
Bioinformatic analysis for potential biological processes and key targets of heart failure-related stroke	11
NEDD8-conjugating enzyme E2 UBE2F confers radiation resistance by protecting lung cancer cells from apoptosis	11
Modulating effects of Astragalus polysaccharide on immune disorders via gut microbiota and the TLR4/NF-κB pathway in rats with syndrome of dampness stagnancy due to spleen deficiency	11
Tumor immune checkpoints and their associated inhibitors	11
Insertion/deletion variants within the IGF2BP2 gene identified in reported genome-wide selective sweep analysis reveal a correlation with goat litter size	11
Phenolic profile of jujube fruit subjected to gut microbiota fermentation and its antioxidant potential against ethyl carbamate-induced oxidative damage	11
Fetal growth, fetal development, and placental features in women with polycystic ovary syndrome: analysis based on fetal and placental magnetic resonance imaging	10
Seasonal coronaviruses and SARS-CoV-2: effects of preexisting immunity during the COVID-19 pandemic	10
Transcriptional memory and response to adverse temperatures in plants	10
Opposite effects of miR-155 in the initial and later stages of lipopolysaccharide (LPS)-induced inflammatory response	10
Toxoplasma gondii infection induces cell apoptosis via multiple pathways revealed by transcriptome analysis	10
Hemin-induced increase in saponin content contributes to the alleviation of osmotic and cold stress damage to Conyza blinii in a heme oxygenase 1-dependent manner	10
Application of antigenic biomarkers for Mycobacterium tuberculosis	10
Basophils as a potential therapeutic target in cancer	10
Exosomes in bladder cancer: novel biomarkers and targets	10
Application of extracorporeal therapies in critically ill COVID-19 patients	10
BCAT1 promotes lung adenocarcinoma progression through enhanced mitochondrial function and NF-κB pathway activation	9
3D brain glioma segmentation in MRI through integrating multiple densely connected 2D convolutional neural networks	9
Structural and physiological changes of the human body upon SARS-CoV-2 infection	9
Cytocompatible cellulose nanofibers from invasive plant species Agave americana L. and Ricinus communis L.: a renewable green source of highly crystalline nanocellulose	9
Transition of autophagy and apoptosis in fibroblasts depends on dominant expression of HIF-1α or p53	9
Cathepsin D knockdown regulates biological behaviors of granulosa cells and affects litter size traits in goats	9
A novel porous silica-zirconia coating for improving bond performance of dental zirconia	9
Advances in post-operative prognostic models for hepatocellular carcinoma	9
Blocking the JAK2/STAT3 and ERK pathways suppresses the proliferation of gastrointestinal cancers by inducing apoptosis	9
Lycium barbarum polysaccharides ameliorate canine acute liver injury by reducing oxidative stress, protecting mitochondrial function, and regulating metabolic pathways	9
HucMSC-Ex alleviates inflammatory bowel disease via the lnc78583-mediated miR3202/HOXB13 pathway	8
Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress	8

Impact of COVID-19 pandemic on the pregnancy outcomes of women undergoing assisted reproductive techniques (ARTs): a systematic review and meta-analysis	8
Effects of gibberellin priming on seedling emergence and transcripts involved in mesocotyl elongation in rice under deep direct-seeding conditions	8
3D printing of bioinspired compartmentalized capsular structure for controlled drug release	8
Silencing of DsbA-L gene impairs the PPARγ agonist function of improving insulin resistance in a high-glucose cell model	8
A novel defined risk signature of endoplasmic reticulum stress-related genes for predicting the prognosis and immune infiltration status of ovarian cancer	8
Potential effect of EGCG on the anti-tumor efficacy of metformin in melanoma cells	8
Development and validation of novel inflammatory response-related gene signature for sepsis prognosis	8
Novel ACADVL variants resulting in mitochondrial defects in long-chain acyl-CoA dehydrogenase deficiency	7
Chinese consensus guidelines for therapeutic drug monitoring of polymyxin B, endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitorin	7
Translationally controlled tumor protein: the mediator promoting cancer invasion and migration and its potential clinical prospects	7
LG-ESSs and HG-ESSs: underlying molecular alterations and potential therapeutic strategies	7
Reduced glycodeoxycholic acid levels are associated with negative clinical outcomes of gestational diabetes mellitus	7
Exosome-mediated regulatory mechanisms in skeletal muscle: a narrative review	7
Comparative metabolomics provides novel insights into the basis of petiole color differences in celery (Apium graveolens L.)	7
New insights on the utilization of ultrasonicated mustard seed cake: chemical composition and antagonistic potential for root-knot nematode, Meloidogyne javanica	7
Arthrospira maxima (Spirulina) prevents endoplasmic reticulum stress in the kidney through its C-phycocyanin	7
Osteogenic effects of antihypertensive drug benidipine on mouse MC3T3-E1 cells in vitro	7
In vivo antioxidant activity of rabbiteye blueberry (Vaccinium ashei cv. ‘Brightwell’) anthocyanin extracts	7
Efficient gene editing in a medaka (Oryzias latipes) cell line and embryos by SpCas9/tRNA-gRNA	7
Luminal androgen receptor (LAR) subtype of triple-negative breast cancer: molecular, morphological, and clinical features	7
Cornuside alleviates experimental autoimmune encephalomyelitis by inhibiting Th17 cell infiltration into the central nervous system	7
Application of regional citrate anticoagulation in patients at high risk of bleeding during intermittent hemodialysis: a prospective multicenter randomized controlled trial	7
Bioactive constituents of animal-derived traditional Chinese medicinal materials for breast cancer: opportunities and challenges	7