Journal of Zhejiang University-Science B

Article	Citations
CRISPR/Cas: a Nobel Prize award-winning precise genome editing technology for gene therapy and crop improvement	108
Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses	91
Research advances in bioactive components and health benefits of jujube (Ziziphus jujuba Mill.) fruit	63
Comparison of COVID-19 and influenza characteristics	43
A novel anticancer property of Lycium barbarum polysaccharide in triggering ferroptosis of breast cancer cells	34
Proteomic characterization of four subtypes of M2 macrophages derived from human THP-1 cells	33
Iron metabolism, ferroptosis, and lncRNA in cancer: knowns and unknowns	27
Autophagy and cancer treatment: four functional forms of autophagy and their therapeutic applications	25
Effects of nanofibers on mesenchymal stem cells: environmental factors affecting cell adhesion and osteogenic differentiation and their mechanisms	24
Hydrogen agronomy: research progress and prospects	24
MRN complex is an essential effector of DNA damage repair	24
Spirulina platensis aqueous extracts ameliorate colonic mucosal damage and modulate gut microbiota disorder in mice with ulcerative colitis by inhibiting inflammation and oxidative stress	22
Modification of polyetheretherketone (PEEK) physical features to improve osteointegration	21
Index of microcirculatory resistance: state-of-the-art and potential applications in computational simulation of coronary artery disease	20
Roles of neutrophil reactive oxygen species (ROS) generation in organ function impairment in sepsis	20
Hypoxia-induced ROS aggravate tumor progression through HIF-1α-SERPINE1 signaling in glioblastoma	20
Biocompatible chitosan/polyethylene glycol/multi-walled carbon nanotube composite scaffolds for neural tissue engineering	20
Target binding and residence: a new determinant of DNA double-strand break repair pathway choice in CRISPR/Cas9 genome editing	19
Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options	19
Screening beneficial bacteriostatic lactic acid bacteria in the intestine and studies of bacteriostatic substances	19
Hydroxychavicol, a polyphenol from Piper betle leaf extract, induces cell cycle arrest and apoptosis in TP53-resistant HT-29 colon cancer cells	18
DNA alkylation lesion repair: outcomes and implications in cancer chemotherapy	18
Efficient genetic transformation and CRISPR/Cas9-mediated genome editing of watermelon assisted by genes encoding developmental regulators	17
Regulation of DNA double-strand break repair pathway choice: a new focus on 53BP1	17
High expression of FABP4 in colorectal cancer and its clinical significance	17

A comprehensive update: gastrointestinal microflora, gastric cancer and gastric premalignant condition, and intervention by traditional Chinese medicine	17
Scutellarin prevents acute alcohol-induced liver injury via inhibiting oxidative stress by regulating the Nrf2/HO-1 pathway and inhibiting inflammation by regulating the AKT, p38 MAPK/NF-κB pathways	17
Integrative analysis of prognostic long non-coding RNAs with copy number variation in bladder cancer	16
Molecular hydrogen is a promising therapeutic agent for pulmonary disease	16
Detection of human papillomavirus in oropharyngeal squamous cell carcinoma	16
Changes in the gut microbiota of osteoporosis patients based on 16S rRNA gene sequencing: a systematic review and meta-analysis	15
Relapse after CAR-T cell therapy in B-cell malignancies: challenges and future approaches	15
Role of deubiquitinating enzymes in DNA double-strand break repair	15
How silicon fertilizer improves nitrogen and phosphorus nutrient availability in paddy soil?	14
Low-intensity pulsed ultrasound ameliorates angiotensin II-induced cardiac fibrosis by alleviating inflammation via a caveolin-1-dependent pathway	14
Electromagnetic field exposure as a plausible approach to enhance the proliferation and differentiation of mesenchymal stem cells in clinically relevant scenarios	14
Chemical characterization of a new sulfated polysaccharide from Gracilaria chouae and its activation effects on RAW264.7 macrophages	14
Research and application advances in rehabilitation assessment of stroke	14
Protective effect of recombinant Lactobacillus plantarum against H2O2-induced oxidative stress in HUVEC cells	14
Chemerin promotes proliferation and migration of ovarian cancer cells by upregulating expression of PD-L1	13
Primary duct closure versus T-tube drainage after laparoscopic common bile duct exploration: a meta-analysis	13
Applications of smartphone-based near-infrared (NIR) imaging, measurement, and spectroscopy technologies to point-of-care (POC) diagnostics	13
A proteomic analysis of Bcl-2 regulation of cell cycle arrest: insight into the mechanisms	13
Tumor-associated macrophages in osteosarcoma	12
Traditional Chinese medicines and their active ingredients sensitize cancer cells to TRAIL-induced apoptosis	12
Insertion/deletion variants within the IGF2BP2 gene identified in reported genome-wide selective sweep analysis reveal a correlation with goat litter size	11
Phenolic profile of jujube fruit subjected to gut microbiota fermentation and its antioxidant potential against ethyl carbamate-induced oxidative damage	11
HDAC inhibitor chidamide synergizes with venetoclax to inhibit the growth of diffuse large B-cell lymphoma via down-regulation of MYC, BCL2, and TP53 expression	11
Inhibitory mechanism of angiotensin-converting enzyme inhibitory peptides from black tea	11
Bioinformatic analysis for potential biological processes and key targets of heart failure-related stroke	11
NEDD8-conjugating enzyme E2 UBE2F confers radiation resistance by protecting lung cancer cells from apoptosis	11
Modulating effects of Astragalus polysaccharide on immune disorders via gut microbiota and the TLR4/NF-κB pathway in rats with syndrome of dampness stagnancy due to spleen deficiency	11
Tumor immune checkpoints and their associated inhibitors	11
Hemin-induced increase in saponin content contributes to the alleviation of osmotic and cold stress damage to Conyza blinii in a heme oxygenase 1-dependent manner	10
Application of antigenic biomarkers for Mycobacterium tuberculosis	10
Basophils as a potential therapeutic target in cancer	10
Exosomes in bladder cancer: novel biomarkers and targets	10
Application of extracorporeal therapies in critically ill COVID-19 patients	10
Fetal growth, fetal development, and placental features in women with polycystic ovary syndrome: analysis based on fetal and placental magnetic resonance imaging	10
Seasonal coronaviruses and SARS-CoV-2: effects of preexisting immunity during the COVID-19 pandemic	10
Transcriptional memory and response to adverse temperatures in plants	10
Opposite effects of miR-155 in the initial and later stages of lipopolysaccharide (LPS)-induced inflammatory response	10
Toxoplasma gondii infection induces cell apoptosis via multiple pathways revealed by transcriptome analysis	10
Advances in post-operative prognostic models for hepatocellular carcinoma	9
Blocking the JAK2/STAT3 and ERK pathways suppresses the proliferation of gastrointestinal cancers by inducing apoptosis	9
Lycium barbarum polysaccharides ameliorate canine acute liver injury by reducing oxidative stress, protecting mitochondrial function, and regulating metabolic pathways	9
BCAT1 promotes lung adenocarcinoma progression through enhanced mitochondrial function and NF-κB pathway activation	9
3D brain glioma segmentation in MRI through integrating multiple densely connected 2D convolutional neural networks	9
Structural and physiological changes of the human body upon SARS-CoV-2 infection	9
Cytocompatible cellulose nanofibers from invasive plant species Agave americana L. and Ricinus communis L.: a renewable green source of highly crystalline nanocellulose	9
Transition of autophagy and apoptosis in fibroblasts depends on dominant expression of HIF-1α or p53	9
Cathepsin D knockdown regulates biological behaviors of granulosa cells and affects litter size traits in goats	9
A novel porous silica-zirconia coating for improving bond performance of dental zirconia	9
A novel defined risk signature of endoplasmic reticulum stress-related genes for predicting the prognosis and immune infiltration status of ovarian cancer	8
Potential effect of EGCG on the anti-tumor efficacy of metformin in melanoma cells	8

Development and validation of novel inflammatory response-related gene signature for sepsis prognosis	8
HucMSC-Ex alleviates inflammatory bowel disease via the lnc78583-mediated miR3202/HOXB13 pathway	8
Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress	8
Impact of COVID-19 pandemic on the pregnancy outcomes of women undergoing assisted reproductive techniques (ARTs): a systematic review and meta-analysis	8
Effects of gibberellin priming on seedling emergence and transcripts involved in mesocotyl elongation in rice under deep direct-seeding conditions	8
3D printing of bioinspired compartmentalized capsular structure for controlled drug release	8
Silencing of DsbA-L gene impairs the PPARγ agonist function of improving insulin resistance in a high-glucose cell model	8
Efficient gene editing in a medaka (Oryzias latipes) cell line and embryos by SpCas9/tRNA-gRNA	7
Luminal androgen receptor (LAR) subtype of triple-negative breast cancer: molecular, morphological, and clinical features	7
Translationally controlled tumor protein: the mediator promoting cancer invasion and migration and its potential clinical prospects	7
LG-ESSs and HG-ESSs: underlying molecular alterations and potential therapeutic strategies	7
Reduced glycodeoxycholic acid levels are associated with negative clinical outcomes of gestational diabetes mellitus	7
Novel ACADVL variants resulting in mitochondrial defects in long-chain acyl-CoA dehydrogenase deficiency	7
Chinese consensus guidelines for therapeutic drug monitoring of polymyxin B, endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitorin	7
New insights on the utilization of ultrasonicated mustard seed cake: chemical composition and antagonistic potential for root-knot nematode, Meloidogyne javanica	7
Arthrospira maxima (Spirulina) prevents endoplasmic reticulum stress in the kidney through its C-phycocyanin	7
Osteogenic effects of antihypertensive drug benidipine on mouse MC3T3-E1 cells in vitro	7
In vivo antioxidant activity of rabbiteye blueberry (Vaccinium ashei cv. ‘Brightwell’) anthocyanin extracts	7
Exosome-mediated regulatory mechanisms in skeletal muscle: a narrative review	7
Comparative metabolomics provides novel insights into the basis of petiole color differences in celery (Apium graveolens L.)	7
Cornuside alleviates experimental autoimmune encephalomyelitis by inhibiting Th17 cell infiltration into the central nervous system	7
Application of regional citrate anticoagulation in patients at high risk of bleeding during intermittent hemodialysis: a prospective multicenter randomized controlled trial	7
Bioactive constituents of animal-derived traditional Chinese medicinal materials for breast cancer: opportunities and challenges	7
Discovery of potential biomarkers for human atherosclerotic abdominal aortic aneurysm through untargeted metabolomics and transcriptomics	6
Effect of Palrnatine on lipopolysaccharide-induced acute lung injury by inhibiting activation of the Akt/NF-κB pathway	6
Optimized thyroid transcription factor-1 core promoter-driven microRNA-7 expression effectively inhibits the growth of human non-small-cell lung cancer cells	6
Investigation and experimental validation of curcumin-related mechanisms against hepatocellular carcinoma based on network pharmacology	6
Successful treatment of refractory pure red cell aplasia with eltrombopag after ABO-incompatible allogeneic hematopoietic stem cell transplantation	6
Current status and future prospects of stomatology research	6
Suppression of NLRP3 inflammasome by ivermectin ameliorates bleomycin-induced pulmonary fibrosis	6
Physicochemical properties, molecular structure, antioxidant activity, and biological function of extracellular melanin from Ascosphaera apis	6
Gastrointestinal toxicities associated with immune checkpoint inhibitors: a disproportionality analysis leveraging VigiBase, the WHO Adverse Drug Reaction Database	6
Nanosilver alleviates foreign body reaction and facilitates wound repair by regulating macrophage polarization	6
Peripheral nerve injury in patients exposed to n-hexane: an analysis of eight cases	6
Development and validation of an individualized nomogram for early prediction of the duration of SARS-CoV-2 shedding in COVID-19 patients with non-severe disease	6
Detection and quantitative analysis of tumor-associated tertiary lymphoid structures	6
A near-infrared spectroscopy-based end-point determination method for the blending process of Dahuang soda tablets	6
LncRNA-m18as1 competitively binds with miR-18a-5p to regulate follicle-stimulating hormone secretion through the Smad2/3 pathway in rat primary pituitary cells	6
Co-regulation of circadian clock genes and microRNAs in bone metabolism	6
Ameliorative effect of scutellarin on acute alcohol brain injury in mice	6
Recent advances in the use of the CRISPR-Cas system for the detection of infectious pathogens	6
High levels of serum IL-10 indicate disease progression, extramedullary involvement, and poor prognosis in multiple myeloma	5
Serum macrophage migration inhibitory factor as a potential biomarker to evaluate therapeutic response in patients with allergic asthma: an exploratory study	5
Evaluation and application of an efficient plant DNA extraction protocol for laboratory and field testing	5
Emerging role of protein modification in inflammatory bowel disease	5
Development and application of bionic systems consisting of tumor-cell membranes	5
Pulsed low-dose rate radiotherapy has an improved therapeutic effect on abdominal and pelvic malignancies	5
Molecular cloning, characterization and expression analysis of three key starch synthesis-related genes from the bulb of a rare lily germplasm, Lilium brownii var. giganteum	5
Exosomes released by melanocytes modulate fibroblasts to promote keloid formation: a pilot study	5
Modeling the neuro-protection of theaflavic acid from black tea and its synergy with nimodipine via mitochondria apoptotic pathway	5
Kidney function change after transcatheter aortic valve replacement in patients with diabetes and/or hypertension	5
Ethical and legal implications of gene editing in plant breeding: a systematic literature review	5
A high-efficiency and versatile CRISPR/Cas9-mediated HDR-based biallelic editing system	5
Tertiary lymphoid structures as unique constructions associated with the organization, education, and function of tumor-infiltrating immunocytes	5
Role of melatonin receptor 1B gene polymorphism and its effect on the regulation of glucose transport in gestational diabetes mellitus	5
Genetic diversity analysis of forty-three insertion/deletion loci for forensic individual identification in Han Chinese from Beijing based on a novel panel	5
Reduced cell invasion may be a characteristic of placental defects in pregnant women of advanced maternal age at single-cell level	5
Short-chain fatty acids ameliorate spinal cord injury recovery by regulating the balance of regulatory T cells and effector IL-17+ γδ T cells	5
Circular RNAs: typical biomarkers for bone-related diseases	5
Urinary donor-derived cell-free DNA as a non-invasive biomarker for BK polyomavirus-associated nephropathy	5
Aerobic glycolysis in colon cancer is repressed by naringin via the HIF1A pathway	5
Targeting TRMT5 suppresses hepatocellular carcinoma progression via inhibiting the HIF-1α pathways	5
Tartary buckwheat database (TBD): an integrative platform for gene analysis of and biological information on Tartary buckwheat	5
Liensinine attenuates inflammation and oxidative stress in spleen tissue in an LPS-induced mouse sepsis model	5
Effects of angiotensin II receptor blocker usage on viral load, antibody dynamics, and transcriptional characteristics among COVID-19 patients with hypertension	5
3D-printed models improve surgical planning for correction of severe postburn ankle contracture with an external fixator	5
Spatial transcriptome analysis of long non-coding RNAs reveals tissue specificity and functional roles in cancer	5
Development of a pyrF-based counterselectable system for targeted gene deletion in Streptomyces rimosus	5
Aqueous extracts from Tenebrio molitor larval and pupal stages inhibit early hepatocarcinogenesis in vivo	5
Lactobacillus gasseri LA39 promotes hepatic primary bile acid biosynthesis and intestinal secondary bile acid biotransformation	5
CircRNA.0007127 triggers apoptosis through the miR-513a-5p/CASP8 axis in K-562 cells	4
Diagnostic value of optic disc retinal nerve fiber layer thickness for diabetic peripheral neuropathy	4
MRI-derived radiomics models for diagnosis, aggressiveness, and prognosis evaluation in prostate cancer	4
Non-suicidal self-harm is linked to suicidal thoughts in Chinese adolescents with mood disorders: a cross-sectional report	4
Effects of S-adenosylmethionine on production of secondary metabolites in Streptomyces diastatochromogenes 1628	4
Composite B-cell and T-cell lymphomas: clinical, pathological, and molecular features of three cases and literature review	4
AIFM1 variants associated with auditory neuropathy spectrum disorder cause apoptosis due to impaired apoptosis-inducing factor dimerization	4
Cytokine receptor-like factor 1 (CRLF1) promotes cardiac fibrosis via ERK1/2 signaling pathway	4
Diacylated anthocyanins from purple sweet potato (Ipomoea batatas L.) attenuate hyperglycemia and hyperuricemia in mice induced by a high-fructose/high-fat diet	4
ZNF750 facilitates carcinogenesis via promoting the expression of long non-coding RNA CYTOR and influences pharmacotherapy response in colon adenocarcinoma	4

Novel perspective in transplantation therapy of mesenchymal stem cells: targeting the ferroptosis pathway	4
Isolated superior mesenteric artery rupture caused by abdominal trauma	4
Mitochondrial fusion protein 2 regulates endoplasmic reticulum stress in preeclampsia	4
Tea tree oil, a vibrant source of neuroprotection via neuroinflammation inhibition: a critical insight into repurposing Melaleuca alternifolia by unfolding its characteristics	4
Clinically applicable artificial intelligence algorithm for the diagnosis, evaluation, and monitoring of acute retinal necrosis	4
High-throughput sequencing identifies salivary microbiota in Chinese caries-free preschool children with primary dentition	4
USH2A mutation and specific driver mutation subtypes are associated with clinical efficacy of immune checkpoint inhibitors in lung cancer	4
Clinical characteristics and plasma antibody titer of patients with COVID-19 in Zhejiang, China	4
Application of a recombinant replicase to localize the Trionyx sinensis hemorrhagic syndrome virus and evaluate its effects on antiviral genes of T. sinensis	4
Engineered Bacillus subtilis alleviates intestinal oxidative injury through Nrf2-Keap1 pathway in enterotoxigenic Escherichia coli (ETEC) K88-infected piglet	4
ERα promotes transcription of tumor suppressor gene ApoA-I by establishing H3K27ac-enriched chromatin microenvironment in breast cancer cells	4
Layers of interstitial fluid flow along a “slit-shaped” vascular adventitia	4
Factors associated with a SARS-CoV-2 recurrence after hospital discharge among patients with COVID-19: systematic review and meta-analysis	4
Defense and anti-defense mechanisms of bacteria and bacteriophages	3
An expandable chamber for safe brain retraction: new technologies in the field of transcranial endoscopic surgery	3
Endoplasmic reticulum stress is involved in retinal injury induced by repeated transient spikes of intraocular pressure	3
Application of silk fibroin coatings for biomaterial surface modification: a silk road for biomedicine	3
Polysaccharide isolated from wax apple suppresses ethyl carbamate-induced oxidative damage in human hepatocytes	3
Genome-wide analysis of microRNA156 and its targets, the genes encoding SQUAMOSA promoter-binding protein-like (SPL) transcription factors, in the grass family Poaceae	3
Overview of the main biological mechanisms linked to changes in periodontal ligament stem cells and the inflammatory microenvironment	3
High-throughput “read-on-ski” automated imaging and label-free detection system for toxicity screening of compounds using personalised human kidney organoids	3
Nrf2-mediated ferroptosis of spermatogenic cells involved in male reproductive toxicity induced by polystyrene nanoplastics in mice	3
Comparative transcriptome analysis of candidate genes involved in chlorogenic acid biosynthesis during fruit development in three pear varieties of Xinjiang Uygur Autonomous Region	3
Rapid visual detection of Vibrio parahaemolyticus by combining LAMP-CRISPR/Cas12b with heat-labile uracil-DNA glycosylase to eliminate carry-over contamination	3
Assessment of quality deviation of pork and salmon due to temperature fluctuations during superchilling	3
Effects of Aeriscardovia aeriphila on growth performance, antioxidant functions, immune responses, and gut microbiota in broiler chickens	3
Safety of protease inhibitors and Arbidol for SARS-CoV-2 pneumonia in Zhejiang Province, China	3
Therapeutic potential of traditional Chinese medicine for vascular endothelial growth factor	3
ADP-ribosylhydrolases: from DNA damage repair to COVID-19	3
Biomarkers of malignant transformation in oral leukoplakia: from bench to bedside	3
UPF1 increases amino acid levels and promotes cell proliferation in lung adenocarcinoma via the eIF2α-ATF4 axis	3
Andrographolide protects against atrial fibrillation by alleviating oxidative stress injury and promoting impaired mitochondrial bioenergetics	3
Chinese young people’s perceptions and preferences with regard to various edible urban plants	3
Mass spectrometry-based protein-protein interaction techniques and their applications in studies of DNA damage repair	3
Aeromonas sobria regulates proinflammatory immune response in mouse macrophages via activating the MAPK, AKT, and NF-κB pathways	3
Development and accuracy of artificial intelligence-generated prediction of facial changes in orthodontic treatment: a scoping review	3
Carotenoid components and their biosynthesis in a bud mutant of Shiranui mandarin (Citrus reticulata Blanco) with citrine flavedo	3