OOIR: Observatory of International Research

Papers

(The TQCC of Cellular & Molecular Immunology is 33. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 500 papers]. The publications cover those that have been published in the past four years, i.e., from 2019-09-01 to 2023-09-01.)

Article	Citations
Functional exhaustion of antiviral lymphocytes in COVID-19 patients	1214
Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine	1193
The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications	775
Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients	687
Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein	477
Necroptosis, pyroptosis and apoptosis: an intricate game of cell death	445
Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies	360
The ORF3a protein of SARS-CoV-2 induces apoptosis in cells	344
Serum IgA, IgM, and IgG responses in COVID-19	342
Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor	294
Tumor-infiltrating lymphocytes in the immunotherapy era	286
NLRP3 inflammasome activation and cell death	277
COVID-19: a new challenge for human beings	269
SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70	248
A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity	234
Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities	224
An update on the regulatory mechanisms of NLRP3 inflammasome activation	210
Myeloid immunosuppression and immune checkpoints in the tumor microenvironment	202
Neutrophil chemoattractant receptors in health and disease: double-edged swords	195
Elevated serum levels of S100A8/A9 and HMGB1 at hospital admission are correlated with inferior clinical outcomes in COVID-19 patients	175
Linear epitopes of SARS-CoV-2 spike protein elicit neutralizing antibodies in COVID-19 patients	153
Epigenetic regulation of macrophages: from homeostasis maintenance to host defense	146
Cancer immunotherapy with γδ T cells: many paths ahead of us	145
The function and clinical application of extracellular vesicles in innate immune regulation	144
Increased immune escape of the new SARS-CoV-2 variant of concern Omicron	141

Novel antibody epitopes dominate the antigenicity of spike glycoprotein in SARS-CoV-2 compared to SARS-CoV	140
Exhaustion and senescence: two crucial dysfunctional states of T cells in the tumor microenvironment	139
Unique immunological profile in patients with COVID-19	136
Macrophages and the maintenance of homeostasis	136
Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors	136
Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses	131
Immunobiology and immunotherapy of HCC: spotlight on innate and innate-like immune cells	128
Gut microbiome, liver immunology, and liver diseases	120
SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response	119
Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids	119
The blood–brain barrier in systemic infection and inflammation	117
SARS-CoV-2-specific T cells in infection and vaccination	115
Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases	115
New insights into the evasion of host innate immunity by Mycobacterium tuberculosis	114
Molecular anatomy and pathogenic actions of Helicobacter pylori CagA that underpin gastric carcinogenesis	111
A novel coronavirus (2019-nCoV) causing pneumonia-associated respiratory syndrome	108
Neutrophils in chronic inflammatory diseases	97
High-dimensional immune profiling by mass cytometry revealed immunosuppression and dysfunction of immunity in COVID-19 patients	97
Pathological and molecular examinations of postmortem testis biopsies reveal SARS-CoV-2 infection in the testis and spermatogenesis damage in COVID-19 patients	92
Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer	90
Dendritic cell migration in inflammation and immunity	89
Tumor-associated myeloid cells: diversity and therapeutic targeting	84
Ubiquitination of SARS-CoV-2 ORF7a promotes antagonism of interferon response	84
CCL5 deficiency promotes liver repair by improving inflammation resolution and liver regeneration through M2 macrophage polarization	83
Activation or exhaustion of CD8+ T cells in patients with COVID-19	79
SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation	79
Emerging SARS-CoV-2 variants reduce neutralization sensitivity to convalescent sera and monoclonal antibodies	78
Physiology of gangliosides and the role of antiganglioside antibodies in human diseases	77
Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods	75
Manganese salts function as potent adjuvants	75
Shared and distinct roles of T peripheral helper and T follicular helper cells in human diseases	75
Immunological mechanisms and therapeutic targets of fatty liver diseases	72
Neutralizing antibodies for the prevention and treatment of COVID-19	72
SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy	70
The cutting-edge progress of immune-checkpoint blockade in lung cancer	68
New insights into the cell- and tissue-specificity of glucocorticoid actions	67
ACOD1 in immunometabolism and disease	66
Signaling from T cell receptors (TCRs) and chimeric antigen receptors (CARs) on T cells	66
Pyroptotic macrophages stimulate the SARS-CoV-2-associated cytokine storm	66
Tertiary lymphoid structures in cancer – considerations for patient prognosis	66
Targeting innate sensing in the tumor microenvironment to improve immunotherapy	65
Human immunology and immunotherapy: main achievements and challenges	65
Metabolism of tissue macrophages in homeostasis and pathology	64
Expansion of atypical memory B cells is a prominent feature of COVID-19	64
Phase I study of CAR-T cells with PD-1 and TCR disruption in mesothelin-positive solid tumors	64
Challenges and strategies for next-generation bispecific antibody-based antitumor therapeutics	63
Neutrophils in liver diseases: pathogenesis and therapeutic targets	62
T cell epitopes in SARS-CoV-2 proteins are substantially conserved in the Omicron variant	62
Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases	62
Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection	61

NKG2A and COVID-19: another brick in the wall	61
T cell immune responses to SARS-CoV-2 and variants of concern (Alpha and Delta) in infected and vaccinated individuals	61
Phages and their potential to modulate the microbiome and immunity	60
NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling	60
Anti-inflammatory mechanisms of the novel cytokine interleukin-38 in allergic asthma	59
Retraction Note to: SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion	59
Dendritic cells in cancer immunology	59
Immunopathobiology and therapeutic targets related to cytokines in liver diseases	57
A compromised specific humoral immune response against the SARS-CoV-2 receptor-binding domain is related to viral persistence and periodic shedding in the gastrointestinal tract	56
Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity	53
Enhancing CAR-T cell efficacy in solid tumors by targeting the tumor microenvironment	53
Ligand recognition by the γδ TCR and discrimination between homeostasis and stress conditions	52
Spaceflight and simulated microgravity suppresses macrophage development via altered RAS/ERK/NFκB and metabolic pathways	51
Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy	51
Local heroes or villains: tissue-resident memory T cells in human health and disease	50
Ferritin nanoparticle-based SARS-CoV-2 RBD vaccine induces a persistent antibody response and long-term memory in mice	50
Epitopes for a 2019-nCoV vaccine	50
USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy	49
Identification of druggable inhibitory immune checkpoints on Natural Killer cells in COVID-19	49
The aryl hydrocarbon receptor and the gut–brain axis	49
Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells	47
Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia	47
The essential functions of mitochondrial dynamics in immune cells	47
Dendritic cells license regulatory B cells to produce IL-10 and mediate suppression of antigen-specific CD8 T cells	46
The roles of microglia in viral encephalitis: from sensome to therapeutic targeting	45
Impact of intracellular innate immune receptors on immunometabolism	45
“Autoinflammatory psoriasis”—genetics and biology of pustular psoriasis	44
Dynamic immune profiling identifies the stronger graft-versus-leukemia (GVL) effects with haploidentical allografts compared to HLA-matched stem cell transplantation	44
Potential contribution of increased soluble IL-2R to lymphopenia in COVID-19 patients	43
Regulation of natural killer cell activity by glucocorticoids, serotonin, dopamine, and epinephrine	42
Recombinant vaccine containing an RBD-Fc fusion induced protection against SARS-CoV-2 in nonhuman primates and mice	42
Protective humoral immunity in SARS-CoV-2 infected pediatric patients	41
Oxidized mitochondrial DNA sensing by STING signaling promotes the antitumor effect of an irradiated immunogenic cancer cell vaccine	41
RRx-001 ameliorates inflammatory diseases by acting as a potent covalent NLRP3 inhibitor	41
SARS-CoV-2-specific T cell immunity to structural proteins in inactivated COVID-19 vaccine recipients	41
HLA class I loss in colorectal cancer: implications for immune escape and immunotherapy	41
Autoimmmune hepatitis	40
Dynamics of the SARS-CoV-2 antibody response up to 10 months after infection	40
Tissue-resident memory T cells and their biological characteristics in the recurrence of inflammatory skin disorders	39
Systematic evaluation of IgG responses to SARS-CoV-2 spike protein-derived peptides for monitoring COVID-19 patients	39
Innate lymphocytes: pathogenesis and therapeutic targets of liver diseases and cancer	39
Microglia as hackers of the matrix: sculpting synapses and the extracellular space	39
Jagged1-mediated myeloid Notch1 signaling activates HSF1/Snail and controls NLRP3 inflammasome activation in liver inflammatory injury	38
IFNγ signaling integrity in colorectal cancer immunity and immunotherapy	38
Clinical development of CAR T cell therapy in China: 2020 update	37
Severe COVID-19 patients exhibit an ILC2 NKG2D+ population in their impaired ILC compartment	37
Delta variant (B.1.617.2) sublineages do not show increased neutralization resistance	37
More bricks in the wall against SARS-CoV-2 infection: involvement of γ9δ2 T cells	37
OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING	37
Therapeutic efficacy of anti-CD19 CAR-T cells in a mouse model of systemic lupus erythematosus	37
Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y12 signaling pathway	36
Maternal and fetal T cells in term pregnancy and preterm labor	36
Immune monitoring of interleukin-7 compassionate use in a critically ill COVID-19 patient	35
Epigenetics in modulating immune functions of stromal and immune cells in the tumor microenvironment	35
Ectopic Tcf1 expression instills a stem-like program in exhausted CD8+ T cells to enhance viral and tumor immunity	35
Systemically comparing host immunity between survived and deceased COVID-19 patients	35
SARS-CoV-2 infection in K18-ACE2 transgenic mice replicates human pulmonary disease in COVID-19	34
Construction of a sustainable 3-hydroxybutyrate-producing probiotic Escherichia coli for treatment of colitis	34
B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling	34
Biology and pathology of the uterine microenvironment and its natural killer cells	33
Tissue-specific Tregs in cancer metastasis: opportunities for precision immunotherapy	33