Cellular & Molecular Immunology

Article	Citations
The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications	1126
Necroptosis, pyroptosis and apoptosis: an intricate game of cell death	731
NLRP3 inflammasome activation and cell death	483
Tumor-infiltrating lymphocytes in the immunotherapy era	396
Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies	390
The ORF3a protein of SARS-CoV-2 induces apoptosis in cells	373
Serum IgA, IgM, and IgG responses in COVID-19	362
Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor	305
An update on the regulatory mechanisms of NLRP3 inflammasome activation	300
Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities	291
SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70	272
A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity	257
Neutrophil chemoattractant receptors in health and disease: double-edged swords	251
Elevated serum levels of S100A8/A9 and HMGB1 at hospital admission are correlated with inferior clinical outcomes in COVID-19 patients	194
Macrophages and the maintenance of homeostasis	184
Cancer immunotherapy with γδ T cells: many paths ahead of us	179
Neutrophils in chronic inflammatory diseases	178
Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses	178
Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases	177
The blood–brain barrier in systemic infection and inflammation	177
Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors	175
Gut microbiome, liver immunology, and liver diseases	174
Increased immune escape of the new SARS-CoV-2 variant of concern Omicron	166
Unique immunological profile in patients with COVID-19	161
Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids	160

Linear epitopes of SARS-CoV-2 spike protein elicit neutralizing antibodies in COVID-19 patients	158
Immunobiology and immunotherapy of HCC: spotlight on innate and innate-like immune cells	154
Dendritic cell migration in inflammation and immunity	153
New insights into the evasion of host innate immunity by Mycobacterium tuberculosis	144
SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response	135
SARS-CoV-2-specific T cells in infection and vaccination	125
Metabolism of tissue macrophages in homeostasis and pathology	124
Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer	115
Activation or exhaustion of CD8+ T cells in patients with COVID-19	107
Manganese salts function as potent adjuvants	106
Pathological and molecular examinations of postmortem testis biopsies reveal SARS-CoV-2 infection in the testis and spermatogenesis damage in COVID-19 patients	103
High-dimensional immune profiling by mass cytometry revealed immunosuppression and dysfunction of immunity in COVID-19 patients	102
The cutting-edge progress of immune-checkpoint blockade in lung cancer	102
Ubiquitination of SARS-CoV-2 ORF7a promotes antagonism of interferon response	102
Tumor-associated myeloid cells: diversity and therapeutic targeting	100
SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy	98
Immunological mechanisms and therapeutic targets of fatty liver diseases	97
Tertiary lymphoid structures in cancer – considerations for patient prognosis	94
SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation	93
Shared and distinct roles of T peripheral helper and T follicular helper cells in human diseases	91
Dendritic cells in cancer immunology	91
Neutralizing antibodies for the prevention and treatment of COVID-19	90
Phase I study of CAR-T cells with PD-1 and TCR disruption in mesothelin-positive solid tumors	90
ACOD1 in immunometabolism and disease	88
Human immunology and immunotherapy: main achievements and challenges	87
Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods	83
Phages and their potential to modulate the microbiome and immunity	83
Neutrophils in liver diseases: pathogenesis and therapeutic targets	83
New insights into the cell- and tissue-specificity of glucocorticoid actions	81
Emerging SARS-CoV-2 variants reduce neutralization sensitivity to convalescent sera and monoclonal antibodies	81
Signaling from T cell receptors (TCRs) and chimeric antigen receptors (CARs) on T cells	81
Challenges and strategies for next-generation bispecific antibody-based antitumor therapeutics	79
Enhancing CAR-T cell efficacy in solid tumors by targeting the tumor microenvironment	74
Pyroptotic macrophages stimulate the SARS-CoV-2-associated cytokine storm	73
Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection	73
Expansion of atypical memory B cells is a prominent feature of COVID-19	72
Ligand recognition by the γδ TCR and discrimination between homeostasis and stress conditions	71
Immunopathobiology and therapeutic targets related to cytokines in liver diseases	69
USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy	69
T cell epitopes in SARS-CoV-2 proteins are substantially conserved in the Omicron variant	67
A compromised specific humoral immune response against the SARS-CoV-2 receptor-binding domain is related to viral persistence and periodic shedding in the gastrointestinal tract	66
Autoimmmune hepatitis	64
NKG2A and COVID-19: another brick in the wall	64
T cell immune responses to SARS-CoV-2 and variants of concern (Alpha and Delta) in infected and vaccinated individuals	64
RRx-001 ameliorates inflammatory diseases by acting as a potent covalent NLRP3 inhibitor	63
“Autoinflammatory psoriasis”—genetics and biology of pustular psoriasis	63
Microglia as hackers of the matrix: sculpting synapses and the extracellular space	62
Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia	62
Therapeutic efficacy of anti-CD19 CAR-T cells in a mouse model of systemic lupus erythematosus	62
Impact of intracellular innate immune receptors on immunometabolism	61

The aryl hydrocarbon receptor and the gut–brain axis	61
Retraction Note to: SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion	60
Ferritin nanoparticle-based SARS-CoV-2 RBD vaccine induces a persistent antibody response and long-term memory in mice	60
The essential functions of mitochondrial dynamics in immune cells	60
IFNγ signaling integrity in colorectal cancer immunity and immunotherapy	57
The roles of microglia in viral encephalitis: from sensome to therapeutic targeting	56
Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells	56
Construction of a sustainable 3-hydroxybutyrate-producing probiotic Escherichia coli for treatment of colitis	56
Protein N-myristoylation: functions and mechanisms in control of innate immunity	55
HLA class I loss in colorectal cancer: implications for immune escape and immunotherapy	54
The soluble glycoprotein NMB (GPNMB) produced by macrophages induces cancer stemness and metastasis via CD44 and IL-33	53
Dynamic immune profiling identifies the stronger graft-versus-leukemia (GVL) effects with haploidentical allografts compared to HLA-matched stem cell transplantation	52
Regulation of natural killer cell activity by glucocorticoids, serotonin, dopamine, and epinephrine	52
Identification of druggable inhibitory immune checkpoints on Natural Killer cells in COVID-19	52
Maternal and fetal T cells in term pregnancy and preterm labor	50
The use of supercytokines, immunocytokines, engager cytokines, and other synthetic cytokines in immunotherapy	50
Recombinant vaccine containing an RBD-Fc fusion induced protection against SARS-CoV-2 in nonhuman primates and mice	48
Tissue-specific Tregs in cancer metastasis: opportunities for precision immunotherapy	48
Oxidized mitochondrial DNA sensing by STING signaling promotes the antitumor effect of an irradiated immunogenic cancer cell vaccine	47
Clinical development of CAR T cell therapy in China: 2020 update	47
OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING	46
Potential contribution of increased soluble IL-2R to lymphopenia in COVID-19 patients	44
Dynamics of the SARS-CoV-2 antibody response up to 10 months after infection	44
Ectopic Tcf1 expression instills a stem-like program in exhausted CD8+ T cells to enhance viral and tumor immunity	44
Biology and pathology of the uterine microenvironment and its natural killer cells	44
Protective humoral immunity in SARS-CoV-2 infected pediatric patients	43
Innate lymphocytes: pathogenesis and therapeutic targets of liver diseases and cancer	42
SARS-CoV-2-specific T cell immunity to structural proteins in inactivated COVID-19 vaccine recipients	42
SARS-CoV-2 infection in K18-ACE2 transgenic mice replicates human pulmonary disease in COVID-19	42
Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y12 signaling pathway	41
Severe COVID-19 patients exhibit an ILC2 NKG2D+ population in their impaired ILC compartment	41
Diet, lipids, and antitumor immunity	41
Delta variant (B.1.617.2) sublineages do not show increased neutralization resistance	40
Epigenetics in modulating immune functions of stromal and immune cells in the tumor microenvironment	40
More bricks in the wall against SARS-CoV-2 infection: involvement of γ9δ2 T cells	40
Systematic evaluation of IgG responses to SARS-CoV-2 spike protein-derived peptides for monitoring COVID-19 patients	40
Protein synthesis, degradation, and energy metabolism in T cell immunity	40
The therapeutic implications of immunosuppressive tumor aerobic glycolysis	39
Cellular and molecular mechanisms breaking immune tolerance in inborn errors of immunity	39
Characterization of SARS-CoV-2-specific humoral immunity and its potential applications and therapeutic prospects	39
Immune monitoring of interleukin-7 compassionate use in a critically ill COVID-19 patient	39
Chimeric antigen receptor- and natural killer cell receptor-engineered innate killer cells in cancer immunotherapy	39
The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway	39
Systemically comparing host immunity between survived and deceased COVID-19 patients	38
Microenvironmental influences on T cell immunity in cancer and inflammation	38
SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells	38
A novel CD4+ CTL subtype characterized by chemotaxis and inflammation is involved in the pathogenesis of Graves’ orbitopathy	37
Metabolic programming in dendritic cells tailors immune responses and homeostasis	36
PD-1 blockade-unresponsive human tumor-infiltrating CD8+ T cells are marked by loss of CD28 expression and rescued by IL-15	36
Interleukin-6 mediates neutrophil mobilization from bone marrow in pulmonary hypertension	35
Cross-reactive antibody immunity against SARS-CoV-2 in children and adults	35
Reprogramming cholesterol metabolism in macrophages and its role in host defense against cholesterol-dependent cytolysins	34
IL-33 in COVID-19: friend or foe?	33
Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m6A demethylation of Nr4a1 mRNA	33
Safety, immunogenicity, and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates	33
CD40 stimulation as a molecular adjuvant for cancer vaccines and other immunotherapies	32
NK cell dysfunction in patients with COVID-19	32
Potentiation of NETs release is novel characteristic of TREM-1 activation and the pharmacological inhibition of TREM-1 could prevent from the deleterious consequences of NETs release in sepsis	32
Multiomics: unraveling the panoramic landscapes of SARS-CoV-2 infection	32
sTREM-1 is a specific biomarker of TREM-1 pathway activation	31
Antigen presentation, autoantibody production, and therapeutic targets in autoimmune liver disease	31
Neutralization of the SARS-CoV-2 Delta variant after heterologous and homologous BNT162b2 or ChAdOx1 nCoV-19 vaccination	31
Targeting monoamine oxidase to dampen NLRP3 inflammasome activation in inflammation	31
Inflammatory processes in the liver: divergent roles in homeostasis and pathology	31
Regulation of antitumor immunity by inflammation-induced epigenetic alterations	30
Manganese enhances the antitumor function of CD8+ T cells by inducing type I interferon production	30
Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties	30
CD24Fc protects against viral pneumonia in simian immunodeficiency virus-infected Chinese rhesus monkeys	30
The deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-mediated NF-κB signaling	30
Transcription tipping points for T follicular helper cell and T-helper 1 cell fate commitment	30
Kidney GATA3+ regulatory T cells play roles in the convalescence stage after antibody-mediated renal injury	30
Sepsis-associated severe interleukin-6 storm in critical coronavirus disease 2019	30
STING signaling activation inhibits HBV replication and attenuates the severity of liver injury and HBV-induced fibrosis	29
Downregulated miR-451a as a feature of the plasma cfRNA landscape reveals regulatory networks of IL-6/IL-6R-associated cytokine storms in COVID-19 patients	29
IRAK4 inhibition: a promising strategy for treating RA joint inflammation and bone erosion	29
Microwave ablation of primary breast cancer inhibits metastatic progression in model mice via activation of natural killer cells	28
Hepatitis B virus evades immune recognition via RNA adenosine deaminase ADAR1-mediated viral RNA editing in hepatocytes	27
FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes	26
Supplying the trip to antibody production—nutrients, signaling, and the programming of cellular metabolism in the mature B lineage	26
Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases	26

Systems-based approaches to study immunometabolism	25
Safety and immunogenicity of a SARS-CoV-2 inactivated vaccine in patients with chronic hepatitis B virus infection	25
The spike protein of SARS-CoV-2 variant A.30 is heavily mutated and evades vaccine-induced antibodies with high efficiency	25
Local and systemic effects of IL-17 in joint inflammation: a historical perspective from discovery to targeting	25
CD147 regulates antitumor CD8+ T-cell responses to facilitate tumor-immune escape	25
Immunometabolism at the intersection of metabolic signaling, cell fate, and systems immunology	24
PCBP1 modulates the innate immune response by facilitating the binding of cGAS to DNA	23
Paving the way towards an effective treatment for multiple sclerosis: advances in cell therapy	23
Adaptive immunity at the crossroads of autophagy and metabolism	23
IL-17 sustains the plasma cell response via p38-mediated Bcl-xL RNA stability in lupus pathogenesis	23
Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis	23
MHC class I-independent activation of virtual memory CD8 T cells induced by chemotherapeutic agent-treated cancer cells	22
PD-L1+ exosomes from bone marrow-derived cells of tumor-bearing mice inhibit antitumor immunity	22
Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool	22
Synthetic vitamin K analogs inhibit inflammation by targeting the NLRP3 inflammasome	21
Kupffer cell restoration after partial hepatectomy is mainly driven by local cell proliferation in IL-6-dependent autocrine and paracrine manners	21
Variations in killer-cell immunoglobulin-like receptor and human leukocyte antigen genes and immunity to malaria	21
Differential efficiencies to neutralize the novel mutants B.1.1.7 and 501Y.V2 by collected sera from convalescent COVID-19 patients and RBD nanoparticle-vaccinated rhesus macaques	21
HIV-1 Vif suppresses antiviral immunity by targeting STING	20
The inhibitor effect of RKIP on inflammasome activation and inflammasome-dependent diseases	20
Expanded natural killer cells augment the antimyeloma effect of daratumumab, bortezomib, and dexamethasone in a mouse model	20
Taurocholic acid inhibits the response to interferon-α therapy in patients with HBeAg-positive chronic hepatitis B by impairing CD8+ T and NK cell function	20
VRK2 is involved in the innate antiviral response by promoting mitostress-induced mtDNA release	20
Implications of metabolism-driven myeloid dysfunctions in cancer therapy	20
Reactivation of latent tuberculosis with TNF inhibitors: critical role of the beta 2 chain of the IL-12 receptor	20
Exploring innate immunity in cancer immunotherapy: opportunities and challenges	19
Homeostasis and regulation of autoreactive B cells	19
No crossreactivity of anti-SARS-CoV-2 spike protein antibodies with Syncytin-1	19
Exosomes derived from nasopharyngeal carcinoma cells induce IL-6 production from macrophages to promote tumorigenesis	18
STING regulates BCR signaling in normal and malignant B cells	18
Changes in the humoral immunity response in SARS-CoV-2 convalescent patients over 8 months	18
Cytokines that target immune killer cells against tumors	18
Resident and migratory adipose immune cells control systemic metabolism and thermogenesis	17
The microbiota is dispensable for the early stages of peripheral regulatory T cell induction within mesenteric lymph nodes	17
A recently described type 2 conventional dendritic cell (cDC2) subset mediates inflammation	17
Distinct roles but cooperative effect of TLR3/9 agonists and PD-1 blockade in converting the immunotolerant microenvironment of irreversible electroporation-ablated tumors	17
Conventional type 1 dendritic cells protect against age-related adipose tissue dysfunction and obesity	17
New insights into follicular helper T cell response and regulation in autoimmune pathogenesis	17
Dexamethasone ameliorates severe pneumonia but slightly enhances viral replication in the lungs of SARS-CoV-2-infected Syrian hamsters	17
Macrophage subsets at the maternal-fetal interface	17
Opposing regulatory functions of the TIM3 (HAVCR2) signalosome in primary effector T cells as revealed by quantitative interactomics	17
The large GTPase Rab44 regulates granule exocytosis in mast cells and IgE-mediated anaphylaxis	17
Single-cell analysis reveals the origins and intrahepatic development of liver-resident IFN-γ-producing γδ T cells	17
Beyond monogenetic rare variants: tackling the low rate of genetic diagnoses in predominantly antibody deficiency	16
Exploring the stage-specific roles of Tcf-1 in T cell development and malignancy at single-cell resolution	16
Vaccine booster efficiently inhibits entry of SARS-CoV-2 omicron variant	16
SEMA3A-mediated crosstalk between prostate cancer cells and tumor-associated macrophages promotes androgen deprivation therapy resistance	16
miR-23a/b suppress cGAS-mediated innate and autoimmunity	15
Placenta-derived IL-32β activates neutrophils to promote preeclampsia development	15
TGF-β-induced CD4+ FoxP3+ regulatory T cell-derived extracellular vesicles modulate Notch1 signaling through miR-449a and prevent collagen-induced arthritis in a murine model	15
The ubiquitin ligase Peli1 inhibits ICOS and thereby Tfh-mediated immunity	15
Recovered COVID-19 patients with recurrent viral RNA exhibit lower levels of anti-RBD antibodies	15
Meteorin-β/Meteorin like/IL-41 attenuates airway inflammation in house dust mite-induced allergic asthma	15