Cellular & Molecular Immunology

Article	Citations
The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications	1310
Necroptosis, pyroptosis and apoptosis: an intricate game of cell death	861
NLRP3 inflammasome activation and cell death	560
Tumor-infiltrating lymphocytes in the immunotherapy era	448
Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities	337
An update on the regulatory mechanisms of NLRP3 inflammasome activation	336
SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70	286
A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity	263
Macrophages and the maintenance of homeostasis	220
Neutrophils in chronic inflammatory diseases	216
The blood–brain barrier in systemic infection and inflammation	203
Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases	202
Elevated serum levels of S100A8/A9 and HMGB1 at hospital admission are correlated with inferior clinical outcomes in COVID-19 patients	198
Gut microbiome, liver immunology, and liver diseases	196
Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors	194
Cancer immunotherapy with γδ T cells: many paths ahead of us	191
Dendritic cell migration in inflammation and immunity	186
Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids	178
Unique immunological profile in patients with COVID-19	176
Increased immune escape of the new SARS-CoV-2 variant of concern Omicron	173
Immunobiology and immunotherapy of HCC: spotlight on innate and innate-like immune cells	168
New insights into the evasion of host innate immunity by Mycobacterium tuberculosis	161
Linear epitopes of SARS-CoV-2 spike protein elicit neutralizing antibodies in COVID-19 patients	159
Metabolism of tissue macrophages in homeostasis and pathology	151
SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response	141

Manganese salts function as potent adjuvants	136
SARS-CoV-2-specific T cells in infection and vaccination	133
Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer	126
Activation or exhaustion of CD8+ T cells in patients with COVID-19	120
SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy	115
The cutting-edge progress of immune-checkpoint blockade in lung cancer	115
Tumor-associated myeloid cells: diversity and therapeutic targeting	112
Immunological mechanisms and therapeutic targets of fatty liver diseases	111
Phase I study of CAR-T cells with PD-1 and TCR disruption in mesothelin-positive solid tumors	111
Pathological and molecular examinations of postmortem testis biopsies reveal SARS-CoV-2 infection in the testis and spermatogenesis damage in COVID-19 patients	110
Ubiquitination of SARS-CoV-2 ORF7a promotes antagonism of interferon response	106
Shared and distinct roles of T peripheral helper and T follicular helper cells in human diseases	105
Dendritic cells in cancer immunology	104
Phages and their potential to modulate the microbiome and immunity	98
SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation	97
Human immunology and immunotherapy: main achievements and challenges	96
Neutralizing antibodies for the prevention and treatment of COVID-19	93
New insights into the cell- and tissue-specificity of glucocorticoid actions	87
Enhancing CAR-T cell efficacy in solid tumors by targeting the tumor microenvironment	86
Neutrophils in liver diseases: pathogenesis and therapeutic targets	85
Emerging SARS-CoV-2 variants reduce neutralization sensitivity to convalescent sera and monoclonal antibodies	85
Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods	84
Ligand recognition by the γδ TCR and discrimination between homeostasis and stress conditions	81
Pyroptotic macrophages stimulate the SARS-CoV-2-associated cytokine storm	79
Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection	79
T cell epitopes in SARS-CoV-2 proteins are substantially conserved in the Omicron variant	78
Immunopathobiology and therapeutic targets related to cytokines in liver diseases	78
USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy	77
RRx-001 ameliorates inflammatory diseases by acting as a potent covalent NLRP3 inhibitor	74
Expansion of atypical memory B cells is a prominent feature of COVID-19	73
Autoimmmune hepatitis	72
Impact of intracellular innate immune receptors on immunometabolism	72
Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia	72
“Autoinflammatory psoriasis”—genetics and biology of pustular psoriasis	71
Ferritin nanoparticle-based SARS-CoV-2 RBD vaccine induces a persistent antibody response and long-term memory in mice	69
A compromised specific humoral immune response against the SARS-CoV-2 receptor-binding domain is related to viral persistence and periodic shedding in the gastrointestinal tract	69
Microglia as hackers of the matrix: sculpting synapses and the extracellular space	69
T cell immune responses to SARS-CoV-2 and variants of concern (Alpha and Delta) in infected and vaccinated individuals	67
Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells	65
Construction of a sustainable 3-hydroxybutyrate-producing probiotic Escherichia coli for treatment of colitis	64
The aryl hydrocarbon receptor and the gut–brain axis	64
IFNγ signaling integrity in colorectal cancer immunity and immunotherapy	62
HLA class I loss in colorectal cancer: implications for immune escape and immunotherapy	62
The roles of microglia in viral encephalitis: from sensome to therapeutic targeting	61
Retraction Note to: SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion	61
The use of supercytokines, immunocytokines, engager cytokines, and other synthetic cytokines in immunotherapy	60
The soluble glycoprotein NMB (GPNMB) produced by macrophages induces cancer stemness and metastasis via CD44 and IL-33	59
Protein N-myristoylation: functions and mechanisms in control of innate immunity	57
Tissue-specific Tregs in cancer metastasis: opportunities for precision immunotherapy	55
Dynamic immune profiling identifies the stronger graft-versus-leukemia (GVL) effects with haploidentical allografts compared to HLA-matched stem cell transplantation	55

Identification of druggable inhibitory immune checkpoints on Natural Killer cells in COVID-19	54
Protein synthesis, degradation, and energy metabolism in T cell immunity	53
OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING	53
Recombinant vaccine containing an RBD-Fc fusion induced protection against SARS-CoV-2 in nonhuman primates and mice	52
Diet, lipids, and antitumor immunity	51
Clinical development of CAR T cell therapy in China: 2020 update	50
Biology and pathology of the uterine microenvironment and its natural killer cells	50
Innate lymphocytes: pathogenesis and therapeutic targets of liver diseases and cancer	48
A novel CD4+ CTL subtype characterized by chemotaxis and inflammation is involved in the pathogenesis of Graves’ orbitopathy	47
The therapeutic implications of immunosuppressive tumor aerobic glycolysis	46
Chimeric antigen receptor- and natural killer cell receptor-engineered innate killer cells in cancer immunotherapy	46
SARS-CoV-2 infection in K18-ACE2 transgenic mice replicates human pulmonary disease in COVID-19	45
Characterization of SARS-CoV-2-specific humoral immunity and its potential applications and therapeutic prospects	45
Dynamics of the SARS-CoV-2 antibody response up to 10 months after infection	45
Severe COVID-19 patients exhibit an ILC2 NKG2D+ population in their impaired ILC compartment	43
Cellular and molecular mechanisms breaking immune tolerance in inborn errors of immunity	43
Metabolic programming in dendritic cells tailors immune responses and homeostasis	42
SARS-CoV-2-specific T cell immunity to structural proteins in inactivated COVID-19 vaccine recipients	42
SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells	41
Interleukin-6 mediates neutrophil mobilization from bone marrow in pulmonary hypertension	40
Immune monitoring of interleukin-7 compassionate use in a critically ill COVID-19 patient	40
Systematic evaluation of IgG responses to SARS-CoV-2 spike protein-derived peptides for monitoring COVID-19 patients	40
Delta variant (B.1.617.2) sublineages do not show increased neutralization resistance	40
Microenvironmental influences on T cell immunity in cancer and inflammation	40
The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway	40
Epigenetics in modulating immune functions of stromal and immune cells in the tumor microenvironment	40
Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties	39
CD40 stimulation as a molecular adjuvant for cancer vaccines and other immunotherapies	38
Potentiation of NETs release is novel characteristic of TREM-1 activation and the pharmacological inhibition of TREM-1 could prevent from the deleterious consequences of NETs release in sepsis	38
Reprogramming cholesterol metabolism in macrophages and its role in host defense against cholesterol-dependent cytolysins	38
Safety, immunogenicity, and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates	37
Manganese enhances the antitumor function of CD8+ T cells by inducing type I interferon production	36
Cross-reactive antibody immunity against SARS-CoV-2 in children and adults	36
IL-33 in COVID-19: friend or foe?	35
Transcription tipping points for T follicular helper cell and T-helper 1 cell fate commitment	35
NK cell dysfunction in patients with COVID-19	35
Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m6A demethylation of Nr4a1 mRNA	34
Multiomics: unraveling the panoramic landscapes of SARS-CoV-2 infection	34
Antigen presentation, autoantibody production, and therapeutic targets in autoimmune liver disease	34
Inflammatory processes in the liver: divergent roles in homeostasis and pathology	34
Sepsis-associated severe interleukin-6 storm in critical coronavirus disease 2019	33
sTREM-1 is a specific biomarker of TREM-1 pathway activation	33
Kidney GATA3+ regulatory T cells play roles in the convalescence stage after antibody-mediated renal injury	32
The deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-mediated NF-κB signaling	32
Regulation of antitumor immunity by inflammation-induced epigenetic alterations	32
Immunometabolism at the intersection of metabolic signaling, cell fate, and systems immunology	31
Downregulated miR-451a as a feature of the plasma cfRNA landscape reveals regulatory networks of IL-6/IL-6R-associated cytokine storms in COVID-19 patients	31
Local and systemic effects of IL-17 in joint inflammation: a historical perspective from discovery to targeting	31
Neutralization of the SARS-CoV-2 Delta variant after heterologous and homologous BNT162b2 or ChAdOx1 nCoV-19 vaccination	31
STING signaling activation inhibits HBV replication and attenuates the severity of liver injury and HBV-induced fibrosis	31
FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes	30
Hepatitis B virus evades immune recognition via RNA adenosine deaminase ADAR1-mediated viral RNA editing in hepatocytes	30
Supplying the trip to antibody production—nutrients, signaling, and the programming of cellular metabolism in the mature B lineage	29
Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases	28
CD147 regulates antitumor CD8+ T-cell responses to facilitate tumor-immune escape	28
Systems-based approaches to study immunometabolism	28
Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool	27
IL-17 sustains the plasma cell response via p38-mediated Bcl-xL RNA stability in lupus pathogenesis	26
Paving the way towards an effective treatment for multiple sclerosis: advances in cell therapy	25
The spike protein of SARS-CoV-2 variant A.30 is heavily mutated and evades vaccine-induced antibodies with high efficiency	25
Safety and immunogenicity of a SARS-CoV-2 inactivated vaccine in patients with chronic hepatitis B virus infection	25
Adaptive immunity at the crossroads of autophagy and metabolism	25
Resident and migratory adipose immune cells control systemic metabolism and thermogenesis	24
Kupffer cell restoration after partial hepatectomy is mainly driven by local cell proliferation in IL-6-dependent autocrine and paracrine manners	24
Reactivation of latent tuberculosis with TNF inhibitors: critical role of the beta 2 chain of the IL-12 receptor	24
Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis	24
HIV-1 Vif suppresses antiviral immunity by targeting STING	24
Synthetic vitamin K analogs inhibit inflammation by targeting the NLRP3 inflammasome	23
Differential efficiencies to neutralize the novel mutants B.1.1.7 and 501Y.V2 by collected sera from convalescent COVID-19 patients and RBD nanoparticle-vaccinated rhesus macaques	22
Taurocholic acid inhibits the response to interferon-α therapy in patients with HBeAg-positive chronic hepatitis B by impairing CD8+ T and NK cell function	22
Exploring innate immunity in cancer immunotherapy: opportunities and challenges	22
VRK2 is involved in the innate antiviral response by promoting mitostress-induced mtDNA release	22
Expanded natural killer cells augment the antimyeloma effect of daratumumab, bortezomib, and dexamethasone in a mouse model	21
Meteorin-β/Meteorin like/IL-41 attenuates airway inflammation in house dust mite-induced allergic asthma	21
The inhibitor effect of RKIP on inflammasome activation and inflammasome-dependent diseases	21
Dexamethasone ameliorates severe pneumonia but slightly enhances viral replication in the lungs of SARS-CoV-2-infected Syrian hamsters	20
New insights into follicular helper T cell response and regulation in autoimmune pathogenesis	20
Implications of metabolism-driven myeloid dysfunctions in cancer therapy	20
Beyond monogenetic rare variants: tackling the low rate of genetic diagnoses in predominantly antibody deficiency	19
Single-cell analysis reveals the origins and intrahepatic development of liver-resident IFN-γ-producing γδ T cells	19

Distinct roles but cooperative effect of TLR3/9 agonists and PD-1 blockade in converting the immunotolerant microenvironment of irreversible electroporation-ablated tumors	19
A recently described type 2 conventional dendritic cell (cDC2) subset mediates inflammation	19
miR-23a/b suppress cGAS-mediated innate and autoimmunity	19
No crossreactivity of anti-SARS-CoV-2 spike protein antibodies with Syncytin-1	19
Priming of NLRP3 inflammasome activation by Msn kinase MINK1 in macrophages	18
The microbiota is dispensable for the early stages of peripheral regulatory T cell induction within mesenteric lymph nodes	18
Vaccine booster efficiently inhibits entry of SARS-CoV-2 omicron variant	18
TGF-β-induced CD4+ FoxP3+ regulatory T cell-derived extracellular vesicles modulate Notch1 signaling through miR-449a and prevent collagen-induced arthritis in a murine model	18
SEMA3A-mediated crosstalk between prostate cancer cells and tumor-associated macrophages promotes androgen deprivation therapy resistance	18
Changes in the humoral immunity response in SARS-CoV-2 convalescent patients over 8 months	18
STING regulates BCR signaling in normal and malignant B cells	18
Conventional type 1 dendritic cells protect against age-related adipose tissue dysfunction and obesity	17
The ubiquitin ligase Peli1 inhibits ICOS and thereby Tfh-mediated immunity	17
Opposing regulatory functions of the TIM3 (HAVCR2) signalosome in primary effector T cells as revealed by quantitative interactomics	17
Placenta-derived IL-32β activates neutrophils to promote preeclampsia development	17
SRSF1 plays a critical role in invariant natural killer T cell development and function	17