Acta Pharmacologica Sinica

Article	Citations
Single-dose methamphetamine administration impairs ORM retrieval in mice via excessive DA-mediated inhibition of PrLGlu activity	298
Author Correction: Discovery of toxoflavin, a potent IRE1α inhibitor acting through structure-dependent oxidative inhibition	196
S670, an amide derivative of 3-O-acetyl-11-keto-β-boswellic acid, induces ferroptosis in human glioblastoma cells by generating ROS and inhibiting STX17-mediated fusion of autophagosome and lysosome	147
ADT-OH inhibits malignant melanoma metastasis in mice via suppressing CSE/CBS and FAK/Paxillin signaling pathway	127
Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-κB p65-activated SLC7A11 transcription	113
Extracellular vesicles in vascular remodeling	113
Targeted degradation of membrane and extracellular proteins with LYTACs	108
Reducing lipid peroxidation attenuates stress-induced susceptibility to herpes simplex virus type 1	101
tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis	98
Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates	93
Identification of Licoflavone C as a cap-dependent endonuclease inhibitor against severe fever with thrombocytopenia syndrome virus	92
Celastrol suppresses the growth of vestibular schwannoma in mice by promoting the degradation of β-catenin	92
Translin deletion impairs cocaine-induced locomotor sensitization and RGS8 expression in the nucleus accumbens	86
GRK2-mediated phosphorylation and de-succinylation of PKM2 reduce macrophage glycolysis in rheumatoid arthritis	84
Compound 38, a novel potent and selective antagonist of adenosine A2A receptor, enhances arousal in mice	82
Cystathionine γ-lyase-derived H2S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase	81
Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren’s syndrome in mice by promoting TEC kinase degradation	79
Natural product-based screening led to the discovery of a novel PXR agonist with anti-cholestasis activity	75
Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson’s disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle	71
Channelopathy of small- and intermediate-conductance Ca2+-activated K+ channels	71
MC1R and melanin-based molecular probes for theranostic of melanoma and beyond	69
Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition	67
Satellite cell-derived exosome-mediated delivery of microRNA-23a/27a/26a cluster ameliorates the renal tubulointerstitial fibrosis in mouse diabetic nephropathy	66
Activating Wnt/β-catenin signaling by autophagic degradation of APC contributes to the osteoblast differentiation effect of soy isoflavone on osteoporotic mesenchymal stem cells	64
Pyroptosis and pyroptosis-inducing cancer drugs	63

The hybrid oncolytic peptide NTP-385 potently inhibits adherent cancer cells by targeting the nucleus	62
Dual-responsive nanoparticles loading bevacizumab and gefitinib for molecular targeted therapy against non-small cell lung cancer	60
Otilonium bromide ameliorates pulmonary fibrosis in mice through activating phosphatase PPM1A	60
Transport mechanism and drug discovery of human monocarboxylate transporter 1	59
Dendritic cell-liposome conjugates reverse immunosuppressive tumor microenvironment for inhibiting colitis-associated colorectal cancer	57
Author Correction: ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway	56
Correction to: EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells	56
143D, a novel selective KRASG12C inhibitor exhibits potent antitumor activity in preclinical models	55
TRADD-mediated pyroptosis contributes to diabetic cardiomyopathy	55
p52-ZER6: a determinant of tumor cell sensitivity to MDM2-p53 binding inhibitors	55
Exploring the distinct activation mechanisms of neuromedin B receptor through multiple replica molecular dynamics simulations and Markov state modeling	55
Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial calcium-mediated renal tubular cell senescence	54
Retraction Note: Physcion inhibits the metastatic potential of human colorectal cancer SW620 cells in vitro by suppressing the transcription factor SOX2	52
Insomnia-related rodent models in drug discovery	51
Gastrodin promotes CNS myelinogenesis and alleviates demyelinating injury by activating the PI3K/AKT/mTOR signaling	51
Antagonism of histamine H3 receptor promotes angiogenesis following focal cerebral ischemia	48
Transcriptional regulation and small compound targeting of ACE2 in lung epithelial cells	47
Thoracic perivascular adipose tissue inhibits VSMC apoptosis and aortic aneurysm formation in mice via the secretome of browning adipocytes	46
Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376	46
Sortilin deletion in the prefrontal cortex and hippocampus ameliorates depressive-like behaviors in mice via regulating ASM/ceramide signaling	45
Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation	44
Flavokawain B alleviates LPS-induced acute lung injury via targeting myeloid differentiation factor 2	44
Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer	43
Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway	43
LN-439A, a novel BAP1 inhibitor, suppresses the growth of basal-like breast cancer by degrading KLF5	42
DNMT inhibition epigenetically restores the cGAS-STING pathway and activates RIG-I/MDA5-MAVS to enhance antitumor immunity	42
Chronic infusion of ELABELA alleviates vascular remodeling in spontaneously hypertensive rats via anti-inflammatory, anti-oxidative and anti-proliferative effects	42
Liver X receptor inverse agonist SR9243 attenuates rheumatoid arthritis via modulating glycolytic metabolism of macrophages	41
Correction: Chemokine CCL2 promotes cardiac regeneration and repair in myocardial infarction mice via activation of the JNK/STAT3 axis	40
FX5, a non-steroidal glucocorticoid receptor antagonist, ameliorates diabetic cognitive impairment in mice	40
Krüppel-like factor 15 ameliorates alcohol-induced liver injury in mice via regulation of the PFKFB3/AKT axis	39
Author Correction: Anti-diabetic drug canagliflozin hinders skeletal muscle regeneration in mice	39
RIPK1 inhibition contributes to lysosomal membrane stabilization in ischemic astrocytes via a lysosomal Hsp70.1B-dependent mechanism	38
AlphaFold3 versus experimental structures: assessment of the accuracy in ligand-bound G protein-coupled receptors	37
Porcupine inhibitor CGX1321 alleviates heart failure with preserved ejection fraction in mice by blocking WNT signaling	37
Selective EZH2 inhibitor zld1039 alleviates inflammation in cisplatin-induced acute kidney injury partially by enhancing RKIP and suppressing NF-κB p65 pathway	37
Selumetinib promotes coronary collateral circulation by inducing M2-like macrophage polarization following myocardial infarction	37
NASH: regulatory considerations for clinical drug development and U.S. FDA approval	37
SAAINT-DB: a comprehensive structural antibody database for antibody modeling and design	37
Regulation of toll-like receptor (TLR) signaling pathways in atherosclerosis: from mechanisms to targeted therapeutics	36
Methionine-choline deficient diet deteriorates DSS-induced murine colitis through disturbance of gut microbes and infiltration of macrophages	36
Deletion of p38γ attenuates ethanol consumption- and acetaminophen-induced liver injury in mice through promoting Dlg1	36
Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol	36
Fangchinoline-mediated autophagy inhibition amplifies antigen presentation and PD-1 blockade efficacy in lung cancer	36
Mitofusin-2 mediates cannabidiol-induced neuroprotection against cerebral ischemia in rats	35
A high-throughput screening campaign against PFKFB3 identified potential inhibitors with novel scaffolds	35
Celastrol attenuates hepatitis C virus translation and inflammatory response in mice by suppressing heat shock protein 90β	35
Preclinical characterization of [18F]D2-LW223: an improved metabolically stable PET tracer for imaging the translocator protein 18 kDa (TSPO) in neuroinflammatory rodent models and non-human primates	35
Contrastive learning-based drug screening model for GluN1/GluN3A inhibitors	34
14-3-3ζ inhibits maladaptive repair in renal tubules by regulating YAP and reduces renal interstitial fibrosis	34

The diverse role of the raphe 5-HTergic systems in epilepsy	34
JOSD2 alleviates acute kidney injury through deubiquitinating SIRT7 and negativity regulating SIRT7-NF-κB inflammatory pathway in renal tubular epithelial cells	34
SGLT2 inhibitor empagliflozin promotes revascularization in diabetic mouse hindlimb ischemia by inhibiting ferroptosis	34
Advances in cannabinoid receptors pharmacology: from receptor structural insights to ligand discovery	33
Chemistry and bioactivity of secondary metabolites from South China Sea marine fauna and flora: recent research advances and perspective	33
Melatonin ameliorates bleomycin-induced pulmonary fibrosis via activating NRF2 and inhibiting galectin-3 expression	33
Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy	33
Co-inhibition of RAGE and TLR4 sensitizes pancreatic cancer to irreversible electroporation in mice by disrupting autophagy	32
Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated fatty liver disease in mice: potential involvement of PANoptosis	32
Identifying a non-conserved site for achieving allosteric covalent inhibition of CECR2	32
Esculetin facilitates post-stroke rehabilitation by inhibiting CKLF1-mediated neutrophil infiltration	32
CP-25 enhances OAT1-mediated absorption of methotrexate in synoviocytes of collagen-induced arthritis rats	32
Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells	32
Circular RNA circDhx32 promotes cardiac inflammatory responses in mouse cardiac ischemia-reperfusion injury via binding to FOXO1 competed with AdipoR1	31
Dezocine as a potent analgesic: overview of its pharmacological characterization	31
Z16b, a natural compound from Ganoderma cochlear is a novel RyR2 stabilizer preventing catecholaminergic polymorphic ventricular tachycardia	31
Endothelial dysfunction: mechanisms and contribution to diseases	31
Molecular recognition of two approved drugs Macimorelin and Anamorelin by the growth hormone secretagogue receptor	30
ROCK1 inhibition improves wound healing in diabetes via RIPK4/AMPK pathway	30
Skullcapflavone II, a novel NQO1 inhibitor, alleviates aristolochic acid I-induced liver and kidney injury in mice	30
Therapeutic potential and pharmacological mechanisms of Traditional Chinese Medicine in gout treatment	29
Phenethyl isothiocyanate inhibits metastasis potential of non-small cell lung cancer cells through FTO mediated TLE1 m6A modification	29
NADPH acts as an endogenous P2X7 receptor modulator to gate neuroinflammatory responses of microglia	29
Adaptor protein Src-homology 2 domain containing E (SH2E) deficiency induces heart defect in zebrafish	28
Wogonin attenuates septic cardiomyopathy by suppressing ALOX15-mediated ferroptosis	28
Development of PI3Kγ selective inhibitors: the strategies and application	28
Scutellarin suppresses triple-negative breast cancer metastasis by inhibiting TNFα-induced vascular endothelial barrier breakdown	28
Proteomic characterization of post-translational modifications in drug discovery	28
Author Correction: Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis	28
Cardiomyocyte peroxisome proliferator-activated receptor α prevents septic cardiomyopathy via improving mitochondrial function	28
Current status and challenges in the drug treatment for fibrotic nonalcoholic steatohepatitis	28
Dehydrocorydaline maintains the vascular smooth muscle cell contractile phenotype by upregulating Spta1	27
Development of orthotopic mouse models for mid-low rectal cancer	27
c-FLIP promotes drug resistance in non-small-cell lung cancer cells via upregulating FoxM1 expression	27
(+)-Borneol enantiomer ameliorates epileptic seizure via decreasing the excitability of glutamatergic transmission	27
Electrophysiological characterization of human KCNT1 channel modulators and the therapeutic potential of hydroquinine and tipepidine in KCNT1 mutation-associated epilepsy mouse model	27
Asiatic acid ameliorates doxorubicin-induced cardiotoxicity by promoting FPN-mediated iron export and inhibiting ferroptosis	27
G-protein coupled receptor kinase 2 mediates rheumatoid arthritis-induced depression-like behaviors via the hippocampal CRHR1 signaling pathway	26
Targeting PI3Kα overcomes resistance to KRasG12C inhibitors mediated by activation of EGFR and/or IGF1R	26
Correction: Empagliflozin and liraglutide ameliorate HFpEF in mice via augmenting the Erbb4 signaling pathway	26
GFPBW1, a β-glucan from Grifola frondosa as vaccine adjuvant: APCs activation and maturation	26
HER3 upregulation reduces DS-8201 sensitivity in HER2-positive tumor cells by ATR/CHK1/FoxO1 signaling cascade	26
Sirtuin 6 mitigates thoracic aortic aneurysm progression via maintenance of mitochondria homeostasis in vascular smooth muscle cells	26
Serum amyloid A3 aggravates bleomycin-induced pulmonary fibrosis through Krüppel-like factor 6-dependent interlukin-36α expression	26
Thioridazine protects against disturbed flow-induced atherosclerosis by inhibiting RhoA/YAP-mediated endothelial inflammation	26
Endothelial deubiquinatase YOD1 mediates Ang II-induced vascular endothelial-mesenchymal transition and remodeling by regulating β-catenin	26
The role of microglia in neurodegenerative diseases: from the perspective of ferroptosis	26
Novel treatment for refractory rheumatoid arthritis with total glucosides of paeony and nobiletin codelivered in a self-nanoemulsifying drug delivery system	26
Bile acid and receptors: biology and drug discovery for nonalcoholic fatty liver disease	25
Peptidoglycan isolated from the fruit of Lycium barbarum alleviates liver fibrosis in mice by regulating the TGF-β/Smad7 signaling and gut microbiota	25
Dorsal raphe GABA-ergic neurons regulate the susceptibility to social transfer of pain in mice	25
zDHHC20-driven S-palmitoylation of CD80 is required for its costimulatory function	25
Ainsliadimer C, a disesquiterpenoid isolated from Ainsliaea macrocephala, ameliorates inflammatory responses in adipose tissue via Sirtuin 1-NLRP3 inflammasome axis	25
Revisiting the role of GDF15 in atherosclerosis in mouse and human	25
NFAT inhibitor 11R-VIVIT ameliorates mouse renal fibrosis after ischemia-reperfusion-induced acute kidney injury	24
Celastrol inhibits the DPYSL2-JAK/STAT pathway by targeting mito-IDHs mediated mitochondrial metabolism to exhaust breast cancer	24
Cardiovascular adverse effects of antiviral therapies for COVID-19: Evidence and plausible mechanisms	24
Aspirin modulates succinylation of PGAM1K99 to restrict the glycolysis through NF-κB/HAT1/PGAM1 signaling in liver cancer	24
Anti-diabetic drug canagliflozin hinders skeletal muscle regeneration in mice	24
PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours	24
Inhibiting mPGES-2 impedes renal cyst growth in mice with polycystic kidney disease	24
Discovery of a nitroaromatic nannocystin with potent in vivo anticancer activity against colorectal cancer by targeting AKT1	24
Caffeic acid phenethyl ester suppresses intestinal FXR signaling and ameliorates nonalcoholic fatty liver disease by inhibiting bacterial bile salt hydrolase activity	24
Author Correction: Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance	23
Effect of autoinduction and food on the pharmacokinetics of furmonertinib and its active metabolite characterized by a population pharmacokinetic model	23
Targeting cyclin-dependent kinase 9 in cancer therapy	23
Gentiopicroside ameliorates psoriasis-like skin lesions in mice via regulating the Keap1-Nrf2 pathway and inhibiting keratinocyte activation	23
Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases	23
Poria cocos: traditional uses, triterpenoid components and their renoprotective pharmacology	23
GPR41 deficiency aggravates type 1 diabetes in streptozotocin-treated mice by promoting dendritic cell maturation	23
Luteolin ameliorates chronic stress-induced depressive-like behaviors in mice by promoting the Arginase-1+ microglial phenotype via a PPARγ-dependent mechanism	23
Prenatal dexamethasone exposure impairs rat blood-testis barrier function and sperm quality in adult offspring via GR/KDM1B/FSTL3/TGFβ signaling	23
Betaine-homocysteine methyltransferase protects against acetaminophen-induced acute liver failure via BACH1-SCD1-oleic acid axis	23
Multifaceted roles of UFMylation in health and disease	22
Pharmacological inhibition of FABP7 by MF 6 counteracts cerebellum dysfunction in an experimental multiple system atrophy mouse model	22
Atypical chemokine receptor 3 induces colorectal tumorigenesis in mice by promoting β-arrestin-NOLC1-fibrillarin-dependent rRNA biogenesis	22
Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway	22
Chronic β-adrenergic stress contributes to cardiomyopathy in rodents with collagen-induced arthritis	22
Inhibiting the Otub1/phosphorylated STAT3 axis for the treatment of non-small cell lung cancer	22
Cyclic GMP-AMP synthase recognizes the physical features of DNA	21

Targeting cholesterol metabolism: a promising therapy strategy for cancer	21
Urolithin A ameliorates obesity-induced metabolic cardiomyopathy in mice via mitophagy activation	21
Activation of D2-like dopamine receptors improves the neuronal network and cognitive function of PPT1KI mice	21
Hypocrellin A from an ethnic medicinal fungus protects against NLRP3-driven gout in mice by suppressing inflammasome activation	21
AXL antibody and AXL-ADC mediate antitumor efficacy via targeting AXL in tumor-intrinsic epithelial-mesenchymal transition and tumor-associated M2-like macrophage	21
Inhibition of HIF-prolyl hydroxylase promotes renal tubule regeneration via the reprogramming of renal proximal tubular cells	21
DZ2002 alleviates corneal angiogenesis and inflammation in rodent models of dry eye disease via regulating STAT3-PI3K-Akt-NF-κB pathway	21
Novel insights into NOD-like receptors in renal diseases	21
Targeted VEGFA therapy in regulating early acute kidney injury and late fibrosis	21
Exploring the constitutive activation mechanism of the class A orphan GPR20	21
Neuropeptide-mediated activation of astrocytes improves stress resilience in mice by modulating cortical neural synapses	21
The PIWI-interacting RNA CRAPIR alleviates myocardial ischemia‒reperfusion injury by reducing p53-mediated apoptosis via binding to SRSF1	20
Tigecycline suppresses colon cancer stem cells and impairs tumor engraftment by targeting SNAI1-regulated epithelial-mesenchymal transition	20
Notoginsenoside R1 protects against myocardial ischemia/reperfusion injury in mice via suppressing TAK1-JNK/p38 signaling	20
Circular RNA hsa_circ_0000288 protects against epilepsy in mice by binding to and stabilizing caprin1 protein	20
GluN2A-NMDA receptor inhibition disinhibits the prefrontal cortex, reduces forced swim immobility, and impairs sensorimotor gating	20
BMP1 inhibitor UK383367 improves MI-induced cardiac remodeling and fibrosis in mice via ameliorating macrophage polarization and mitochondrial dysfunction	20
Inhibition of Setd7 protects against cardiomyocyte hypertrophy via inhibiting lipid oxidation	20
Somatostatin receptor 2 targeting peptide modifications for peptide-drug conjugate treatment of small cell lung cancer	20
Correction: A novel annexin dimer targets microglial phagocytosis of astrocytes to protect the brain-blood barrier after cerebral ischemia	20
GLP-1 mimetics as a potential therapy for nonalcoholic steatohepatitis	20
Deep learning enables the discovery of a novel cuproptosis-inducing molecule for the inhibition of hepatocellular carcinoma	20
Characterization of LTr1 derived from cruciferous vegetables as a novel anti-glioma agent via inhibiting TrkA/PI3K/AKT pathway	19
ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway	19
Dysregulation of iron homeostasis and methamphetamine reward behaviors in Clk1-deficient mice	19
SARS-CoV-2 receptor binding domain radio-probe: a non-invasive approach for angiotensin-converting enzyme 2 mapping in mice	19
Dl-3-n-butylphthalide promotes angiogenesis in ischemic stroke mice through upregulating autocrine and paracrine sonic hedgehog	19
Cardiac-specific deletion of BRG1 ameliorates ventricular arrhythmia in mice with myocardial infarction	19
Adiponectin receptor agonist AdipoRon modulates human and mouse platelet function	19
Inhibition of CD36 ameliorates mouse spinal cord injury by accelerating microglial lipophagy	19
Brigatinib, a newly discovered AXL inhibitor, suppresses AXL-mediated acquired resistance to osimertinib in EGFR-mutated non-small cell lung cancer	19
Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis	19
NADPHnet: a novel strategy to predict compounds for regulation of NADPH metabolism via network-based methods	19
Modeling exposure-driven adverse events of EGFR TKIs in the treatment of patients with non-small cell lung cancer	19
Updates on novel pharmacotherapeutics for the treatment of nonalcoholic steatohepatitis	19
Serum granulosa cell-derived TNF-α promotes inflammation and apoptosis of renal tubular cells and PCOS-related kidney injury through NF-κB signaling	18
124I-labeled anti-CD147 antibody for noninvasive detection of CD147-positive pan-cancers: construction and preclinical studies	18
Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson’s disease treatment	18
USP11 promotes renal tubular cell pyroptosis and fibrosis in UUO mice via inhibiting KLF4 ubiquitin degradation	18
Novel Caspase-1 inhibitor CZL80 improves neurological function in mice after progressive ischemic stroke within a long therapeutic time-window	18
Discovery of novel GluN1/GluN3A NMDA receptor inhibitors using a deep learning-based method	18
Colchicine reduces neointima formation and VSMC phenotype transition by modulating SRF-MYOCD activation and autophagy	18
PHLDA1 contributes to hypoxic ischemic brain injury in neonatal rats via inhibiting FUNDC1-mediated mitophagy	18
Discovery of FO-4-15, a novel 1,2,4-oxadiazole derivative, ameliorates cognitive impairments in 3×Tg mice by activating the mGluR1/CaMKIIα pathway	18
Pentapeptide PYRAE triggers ER stress-mediated apoptosis of breast cancer cells in mice by targeting RHBDF1-BiP interaction	18
Decoding ligand recognition and constitutive activation of histamine H3 and H4 receptors	18
Indoxyl sulphate-TNFα axis mediates uremic encephalopathy in rodent acute kidney injury	18
An efficient deep learning-based strategy to screen inhibitors for GluN1/GluN3A receptor	18
Aberrant neuronal excitation promotes neuroinflammation in the primary motor cortex of ischemic stroke mice	18
Thermoregulatory pathway underlying the pyrogenic effects of prostaglandin E2 in the lateral parabrachial nucleus of male rats	18
A novel selective ERK1/2 inhibitor, Laxiflorin B, targets EGFR mutation subtypes in non-small-cell lung cancer	18
AI-enhanced virtual screening approach to hit identification for GluN1/GluN3A NMDA receptor	18
Heat shock protein family A member 8 serving as a co-activator of transcriptional factor ETV4 up-regulates PHLDA2 to promote the growth of liver cancer	18
Inhibiting the transcription and replication of Ebola viruses by disrupting the nucleoprotein and VP30 protein interaction with small molecules	18
Tetramethylpyrazine prevents liver fibrotic injury in mice by targeting hepatocyte-derived and mitochondrial DNA-enriched extracellular vesicles	17
Chemokine CCL2 promotes cardiac regeneration and repair in myocardial infarction mice via activation of the JNK/STAT3 axis	17
Liver receptor homolog-1: structures, related diseases, and drug discovery	17
Role of thrombospondin-1 in high-salt–induced mesenteric artery endothelial impairment in rats	17
Deubiquitinating enzyme USP11 promotes renal tubular cell senescence and fibrosis via inhibiting the ubiquitin degradation of TGF-β receptor II	17
Differential modulation of subthalamic projection neurons by short-term and long-term electrical stimulation in physiological and parkinsonian conditions	17
A novel small-molecule PCSK9 inhibitor E28362 ameliorates hyperlipidemia and atherosclerosis	17
α-MSH-catabolic enzyme prolylcarboxypeptidase in nucleus accumbens shell ameliorates stress susceptibility in mice through regulating synaptic plasticity	17
Dihydroartemisinin suppresses renal fibrosis in mice by inhibiting DNA-methyltransferase 1 and increasing Klotho	17
MMP-9 inhibitor SB-3CT improves neurological outcomes in ischemic stroke mice by modulation of astrocytic lipid metabolism	17
Author Correction: α-Galactosylceramide and its analog OCH differentially affect the pathogenesis of ISO-induced cardiac injury in mice	17
Norcantharidin promotes M1 macrophage polarization and suppresses colorectal cancer growth	17
Disturbance of suprachiasmatic nucleus function improves cardiac repair after myocardial infarction by IGF2-mediated macrophage transition	16
ROS-induced degradation of hERG potassium channels contributes to aripiprazole-induced prolongation of the QTc interval	16
Activation of TRPV1 receptor facilitates myelin repair following demyelination via the regulation of microglial function	16
Mass spectrometry imaging: new eyes on natural products for drug research and development	16
Functional characterization and in vitro pharmacological rescue of KCNQ2 pore mutations associated with epileptic encephalopathy	16
O-GlcNAcylation mediates H2O2-induced apoptosis through regulation of STAT3 and FOXO1	16
The aminosteroid U73122 promotes oligodendrocytes generation and myelin formation	16
A structure-based virtual screening identifies a novel MDM2 antagonist in the activation of the p53 signaling and inhibition of tumor growth	16
HDAC inhibitor GCJ-490A modulates tumor microenvironment and synergizes with PD-1 antibody against breast and lung cancers in syngeneic murine models	16
Mesenchymal stem cells in fibrotic diseases—the two sides of the same coin	16
TGFβR-1/ALK5 inhibitor RepSox induces enteric glia-to-neuron transition and influences gastrointestinal mobility in adult mice	16
Ivacaftor, a CFTR potentiator, synergizes with osimertinib against acquired resistance to osimertinib in NSCLC by regulating CFTR-PTEN-AKT axis	16