Acta Pharmacologica Sinica

Article	Citations
Compound 38, a novel potent and selective antagonist of adenosine A2A receptor, enhances arousal in mice	385
Author Correction: Discovery of toxoflavin, a potent IRE1α inhibitor acting through structure-dependent oxidative inhibition	213
Single-dose methamphetamine administration impairs ORM retrieval in mice via excessive DA-mediated inhibition of PrLGlu activity	188
Identification of Licoflavone C as a cap-dependent endonuclease inhibitor against severe fever with thrombocytopenia syndrome virus	170
Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren’s syndrome in mice by promoting TEC kinase degradation	119
Magnolin overcomes EGFR TKI resistance in NSCLC by modulation of NDRG1-NRG2-HECW1 pathway	119
Translin deletion impairs cocaine-induced locomotor sensitization and RGS8 expression in the nucleus accumbens	118
CSF1R inhibitor C19 for glioma immunotherapy enabled by brain-targeting liposomal delivery	113
Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition	107
Activating Wnt/β-catenin signaling by autophagic degradation of APC contributes to the osteoblast differentiation effect of soy isoflavone on osteoporotic mesenchymal stem cells	105
Molecular mechanisms for sustaining cancer stem cells characteristics and targeted therapeutic strategies	103
ER-phagy receptors: structural mechanisms in selective ER degradation and disease implications	90
Cystathionine γ-lyase-derived H2S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase	90
Satellite cell-derived exosome-mediated delivery of microRNA-23a/27a/26a cluster ameliorates the renal tubulointerstitial fibrosis in mouse diabetic nephropathy	89
Otilonium bromide ameliorates pulmonary fibrosis in mice through activating phosphatase PPM1A	87
Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates	86
Targeted degradation of membrane and extracellular proteins with LYTACs	86
MC1R and melanin-based molecular probes for theranostic of melanoma and beyond	85
Reducing lipid peroxidation attenuates stress-induced susceptibility to herpes simplex virus type 1	85
S670, an amide derivative of 3-O-acetyl-11-keto-β-boswellic acid, induces ferroptosis in human glioblastoma cells by generating ROS and inhibiting STX17-mediated fusion of autophagosome and lysosome	83
tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis	81
Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-κB p65-activated SLC7A11 transcription	78
Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson’s disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle	77
GRK2-mediated phosphorylation and de-succinylation of PKM2 reduce macrophage glycolysis in rheumatoid arthritis	77
Resibufogenin ameliorates cerebral ischemia-reperfusion injury by modulating microglial redox homeostasis via Keap1-Nrf2-TFR1/ARE axis	76

Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer	74
143D, a novel selective KRASG12C inhibitor exhibits potent antitumor activity in preclinical models	73
Insomnia-related rodent models in drug discovery	73
Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation	69
Cell-based cancer immunotherapy: milestones, mechanistic insights, and emerging therapeutic directions	68
Correction to: EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells	65
Author Correction: ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway	65
Retraction Note: Physcion inhibits the metastatic potential of human colorectal cancer SW620 cells in vitro by suppressing the transcription factor SOX2	63
Exploring the distinct activation mechanisms of neuromedin B receptor through multiple replica molecular dynamics simulations and Markov state modeling	62
Gastrodin promotes CNS myelinogenesis and alleviates demyelinating injury by activating the PI3K/AKT/mTOR signaling	59
DNMT1-mediated central amygdala to locus coeruleus circuit contributes to chronic pain-related depression in mice	56
Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial calcium-mediated renal tubular cell senescence	56
ATF3/SOX11-regulated FST activates IGF1R–ERK/AKT–Sp1 signaling to sustain trigeminal neuropathic pain	56
Liver X receptor inverse agonist SR9243 attenuates rheumatoid arthritis via modulating glycolytic metabolism of macrophages	55
Thoracic perivascular adipose tissue inhibits VSMC apoptosis and aortic aneurysm formation in mice via the secretome of browning adipocytes	55
p52-ZER6: a determinant of tumor cell sensitivity to MDM2-p53 binding inhibitors	54
TRADD-mediated pyroptosis contributes to diabetic cardiomyopathy	54
Dendritic cell-liposome conjugates reverse immunosuppressive tumor microenvironment for inhibiting colitis-associated colorectal cancer	52
Transport mechanism and drug discovery of human monocarboxylate transporter 1	52
LN-439A, a novel BAP1 inhibitor, suppresses the growth of basal-like breast cancer by degrading KLF5	52
Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway	52
SGLT2 inhibitor empagliflozin promotes revascularization in diabetic mouse hindlimb ischemia by inhibiting ferroptosis	51
GATA3 drives chronic stress-induced depressive-like behaviors by reducing hippocampal CA3 pyramidal neuronal activity in male mice	51
Methionine-choline deficient diet deteriorates DSS-induced murine colitis through disturbance of gut microbes and infiltration of macrophages	51
DNMT inhibition epigenetically restores the cGAS-STING pathway and activates RIG-I/MDA5-MAVS to enhance antitumor immunity	51
Dendritic cell diversity and dysfunction in cancer: implications for immunotherapy and therapeutic targeting	50
Krüppel-like factor 15 ameliorates alcohol-induced liver injury in mice via regulation of the PFKFB3/AKT axis	49
SAAINT-DB: a comprehensive structural antibody database for antibody modeling and design	49
Contrastive learning-based drug screening model for GluN1/GluN3A inhibitors	48
Author Correction: Anti-diabetic drug canagliflozin hinders skeletal muscle regeneration in mice	47
RIPK1 inhibition contributes to lysosomal membrane stabilization in ischemic astrocytes via a lysosomal Hsp70.1B-dependent mechanism	47
Correction: Chemokine CCL2 promotes cardiac regeneration and repair in myocardial infarction mice via activation of the JNK/STAT3 axis	47
Echoes in the powerhouse: mito-lncRNAs contribution to cardiac function and disease	46
A high-throughput screening campaign against PFKFB3 identified potential inhibitors with novel scaffolds	46
Preclinical characterization of [18F]D2-LW223: an improved metabolically stable PET tracer for imaging the translocator protein 18 kDa (TSPO) in neuroinflammatory rodent models and non-human primates	46
Selumetinib promotes coronary collateral circulation by inducing M2-like macrophage polarization following myocardial infarction	46
Time-resolved proteomic and phosphoproteomic analysis reveals convergent and divergent biological perturbations induced by FDA-approved CDK4/6 inhibitors in hormone receptor-positive breast cancers	45
Chemistry and bioactivity of secondary metabolites from South China Sea marine fauna and flora: recent research advances and perspective	44
Fangchinoline-mediated autophagy inhibition amplifies antigen presentation and PD-1 blockade efficacy in lung cancer	44
Mitofusin-2 mediates cannabidiol-induced neuroprotection against cerebral ischemia in rats	43
UBC9-mediated p53 SUMOylation drives tubular senescence and exacerbates acute kidney injury in mice	43
Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy	42
Celastrol attenuates hepatitis C virus translation and inflammatory response in mice by suppressing heat shock protein 90β	42
Advances in cannabinoid receptors pharmacology: from receptor structural insights to ligand discovery	41
JOSD2 alleviates acute kidney injury through deubiquitinating SIRT7 and negativity regulating SIRT7-NF-κB inflammatory pathway in renal tubular epithelial cells	41
Melatonin ameliorates bleomycin-induced pulmonary fibrosis via activating NRF2 and inhibiting galectin-3 expression	41
AlphaFold3 versus experimental structures: assessment of the accuracy in ligand-bound G protein-coupled receptors	41
Pharmacological strategies to enhance the response of hepatoblastoma to chemotherapy through MDR1 inhibition	40
KCNE2 upregulation improves cardiac function by inhibiting Smurf1-mediated SERCA2a degradation in diabetic cardiomyopathy in mice	39
Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated fatty liver disease in mice: potential involvement of PANoptosis	39

Porcupine inhibitor CGX1321 alleviates heart failure with preserved ejection fraction in mice by blocking WNT signaling	38
BMAL1 silencing as a promising chemosensitizing strategy for triple-negative breast cancer	38
Regulation of toll-like receptor (TLR) signaling pathways in atherosclerosis: from mechanisms to targeted therapeutics	38
Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol	38
Modest improvement of metabolic and behavioral deficits with long-term ambroxol treatment in a Pink1−/−SNCAA53T double mutant mouse model of Parkinson’s disease	38
ROCK1 inhibition improves wound healing in diabetes via RIPK4/AMPK pathway	37
Therapeutic potential and pharmacological mechanisms of Traditional Chinese Medicine in gout treatment	37
Molecular recognition of two approved drugs Macimorelin and Anamorelin by the growth hormone secretagogue receptor	37
Repurposing atorvastatin for uterine leiomyosarcoma: mevalonate pathway inhibition yields preclinical antitumor efficacy	37
Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells	37
Circular RNA circDhx32 promotes cardiac inflammatory responses in mouse cardiac ischemia-reperfusion injury via binding to FOXO1 competed with AdipoR1	36
A modified tail suspension test for the assessment of behavioral despair in mice after stroke	36
Correction: Deguelin inhibits growth and prolactin synthesis in prolactinomas by targeting the PI3K/AKT/CREB3L1 pathway and ornithine decarboxylase	36
Discovery of vasodilatory effects of Na+/H+ exchanger 1 inhibitors to treat vasospastic angina	36
Few-shot learning-driven discovery of Lutein suppresses Th1-mediated inflammation via glucose metabolism	35
Esculetin facilitates post-stroke rehabilitation by inhibiting CKLF1-mediated neutrophil infiltration	35
Proteomic characterization of post-translational modifications in drug discovery	34
Morchella polysaccharide ameliorates myocardial infarction inflammation in mice through increasing gut microbiota-derived 12-HEPE	34
Phenethyl isothiocyanate inhibits metastasis potential of non-small cell lung cancer cells through FTO mediated TLE1 m6A modification	33
Rebalancing the inflammatory trajectory from inflammatory bowel disease to colitis-associated colorectal cancer via artemisinin-based multitarget therapy	33
Co-inhibition of RAGE and TLR4 sensitizes pancreatic cancer to irreversible electroporation in mice by disrupting autophagy	33
Visible light reprograms MSCs and T cells into tumor-suppressive states via OPN4-mediated epigenetic remodeling	33
Fangchinoline restores TFEB-driven lysosomal biogenesis and blocks H1N1 infection	33
Wogonin attenuates septic cardiomyopathy by suppressing ALOX15-mediated ferroptosis	33
Author Correction: Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis	32
Cardiomyocyte peroxisome proliferator-activated receptor α prevents septic cardiomyopathy via improving mitochondrial function	32
Inhibiting mPGES-2 impedes renal cyst growth in mice with polycystic kidney disease	32
Endothelial dysfunction: mechanisms and contribution to diseases	32
NADPH acts as an endogenous P2X7 receptor modulator to gate neuroinflammatory responses of microglia	32
Correction: Empagliflozin and liraglutide ameliorate HFpEF in mice via augmenting the Erbb4 signaling pathway	32
Identifying a non-conserved site for achieving allosteric covalent inhibition of CECR2	32
Skullcapflavone II, a novel NQO1 inhibitor, alleviates aristolochic acid I-induced liver and kidney injury in mice	32
Serum amyloid A3 aggravates bleomycin-induced pulmonary fibrosis through Krüppel-like factor 6-dependent interlukin-36α expression	31
Adaptor protein Src-homology 2 domain containing E (SH2E) deficiency induces heart defect in zebrafish	31
(+)-Borneol enantiomer ameliorates epileptic seizure via decreasing the excitability of glutamatergic transmission	31
G-protein coupled receptor kinase 2 mediates rheumatoid arthritis-induced depression-like behaviors via the hippocampal CRHR1 signaling pathway	31
HER3 upregulation reduces DS-8201 sensitivity in HER2-positive tumor cells by ATR/CHK1/FoxO1 signaling cascade	31
Development of orthotopic mouse models for mid-low rectal cancer	31
Development of PI3Kγ selective inhibitors: the strategies and application	31
Sonic Hedgehog-Gli1 signaling promotes microglial activation via the IKKβ/NF-κB pathway	30
Electrophysiological characterization of human KCNT1 channel modulators and the therapeutic potential of hydroquinine and tipepidine in KCNT1 mutation-associated epilepsy mouse model	30
Cardiovascular adverse effects of antiviral therapies for COVID-19: Evidence and plausible mechanisms	30
TIGAR overexpression alleviates intracerebral hemorrhage injury in mice by suppressing ATF4/NOX4/p22phox-mediated oxidative stress and inflammation	30
Dehydrocorydaline maintains the vascular smooth muscle cell contractile phenotype by upregulating Spta1	29
MIF tautomerase inhibitor 4-IPP alleviates HFD-induced obesity by restoring CD137-mediated browning of white adipocytes in mice	29
Discovery of a nitroaromatic nannocystin with potent in vivo anticancer activity against colorectal cancer by targeting AKT1	29
Dorsal raphe GABA-ergic neurons regulate the susceptibility to social transfer of pain in mice	29
zDHHC20-driven S-palmitoylation of CD80 is required for its costimulatory function	28
Transcription factor targeting strategies in cancer: mechanisms, challenges and cutting-edge progress	28
Discovery of non-opioid peptides that selectively relieve mechanical pain in rodents through inhibition of TRPV4 channels	28
Celastrol inhibits the DPYSL2-JAK/STAT pathway by targeting mito-IDHs mediated mitochondrial metabolism to exhaust breast cancer	28
Sirtuin 6 mitigates thoracic aortic aneurysm progression via maintenance of mitochondria homeostasis in vascular smooth muscle cells	27
The role of microglia in neurodegenerative diseases: from the perspective of ferroptosis	27
Thioridazine protects against disturbed flow-induced atherosclerosis by inhibiting RhoA/YAP-mediated endothelial inflammation	27
Targeting PI3Kα overcomes resistance to KRasG12C inhibitors mediated by activation of EGFR and/or IGF1R	27
Peptidoglycan isolated from the fruit of Lycium barbarum alleviates liver fibrosis in mice by regulating the TGF-β/Smad7 signaling and gut microbiota	27
GFPBW1, a β-glucan from Grifola frondosa as vaccine adjuvant: APCs activation and maturation	27
PPARβ/δ contributes to the antidiabetic effect and the increase in GDF15 caused by metformin	26
Endothelial deubiquinatase YOD1 mediates Ang II-induced vascular endothelial-mesenchymal transition and remodeling by regulating β-catenin	26
Prenatal dexamethasone exposure impairs rat blood-testis barrier function and sperm quality in adult offspring via GR/KDM1B/FSTL3/TGFβ signaling	26
Targeting cholesterol metabolism: a promising therapy strategy for cancer	26
Poria cocos: traditional uses, triterpenoid components and their renoprotective pharmacology	26
Author Correction: Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance	26
Astrocytic adrenergic α2 receptor contributes to the mechanisms underlying the circadian rhythmicity of seizure susceptibility	26
Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway	26
Revisiting the role of GDF15 in atherosclerosis in mouse and human	26
Asiatic acid ameliorates doxorubicin-induced cardiotoxicity by promoting FPN-mediated iron export and inhibiting ferroptosis	26
Chronic β-adrenergic stress contributes to cardiomyopathy in rodents with collagen-induced arthritis	26
Cyclic GMP-AMP synthase recognizes the physical features of DNA	25
Chloroethylnitrosourea analogue HJ03 overcomes temozolomide resistance of glioblastoma in mice through induction of ferroptosis and apoptosis	25
Deficient chaperone-mediated autophagy drives multiorgan fibrogenesis via SMAD2/4 stabilization to sustain TGFβ-SMAD signaling	25
Betaine-homocysteine methyltransferase protects against acetaminophen-induced acute liver failure via BACH1-SCD1-oleic acid axis	25
Correction: Aspirin alleviates cardiac fibrosis in mice by inhibiting autophagy	25
GPR41 deficiency aggravates type 1 diabetes in streptozotocin-treated mice by promoting dendritic cell maturation	25
Technology-enabled insights into SLC transporters in MAFLD: redefining the multi-hit pathogenesis and therapeutic landscape	25
Sweetening the bonds: how O-GlcNAcylation modulates cell adhesion	25
Exploring the constitutive activation mechanism of the class A orphan GPR20	24
Luteolin ameliorates chronic stress-induced depressive-like behaviors in mice by promoting the Arginase-1+ microglial phenotype via a PPARγ-dependent mechanism	24
Targeted VEGFA therapy in regulating early acute kidney injury and late fibrosis	24
Gentiopicroside ameliorates psoriasis-like skin lesions in mice via regulating the Keap1-Nrf2 pathway and inhibiting keratinocyte activation	24

Serum/glucocorticoid-regulated kinase 1 regulates vascular inflammation in atherosclerosis	24
Hypocrellin A from an ethnic medicinal fungus protects against NLRP3-driven gout in mice by suppressing inflammasome activation	23
Evolution of KRAS molecular glues: from allele-selective to Pan-RAS and protein–protein interaction modulators	23
Pharmacological inhibition of FABP7 by MF 6 counteracts cerebellum dysfunction in an experimental multiple system atrophy mouse model	23
Multifaceted roles of UFMylation in health and disease	23
Inhibiting the Otub1/phosphorylated STAT3 axis for the treatment of non-small cell lung cancer	23
β-Sitosterol ameliorates metabolic dysfunction-associated steatohepatitis by targeting the RAC1/mTOR/TFEB axis thus activating lipophagy-lysosomal pathway	23
Correction: A novel annexin dimer targets microglial phagocytosis of astrocytes to protect the brain-blood barrier after cerebral ischemia	23
AXL antibody and AXL-ADC mediate antitumor efficacy via targeting AXL in tumor-intrinsic epithelial-mesenchymal transition and tumor-associated M2-like macrophage	23
DZ2002 alleviates corneal angiogenesis and inflammation in rodent models of dry eye disease via regulating STAT3-PI3K-Akt-NF-κB pathway	23
Modeling exposure-driven adverse events of EGFR TKIs in the treatment of patients with non-small cell lung cancer	23
GluN2A-NMDA receptor inhibition disinhibits the prefrontal cortex, reduces forced swim immobility, and impairs sensorimotor gating	23
Characterization of LTr1 derived from cruciferous vegetables as a novel anti-glioma agent via inhibiting TrkA/PI3K/AKT pathway	22
Somatostatin receptor 2 targeting peptide modifications for peptide-drug conjugate treatment of small cell lung cancer	22
Metabolic checkpoint blockade of IL4I1 by ZY-MY-111 reactivates CD8+ T cell immunity and suppresses tumor growth	22
Targeting RSK2 enhances the efficacy of IGF1R inhibitor against triple-negative breast cancer via antagonizing IGF1/IGF1R signaling mediated by GATA3-IGFBP5 pathway	22
Activation of D2-like dopamine receptors improves the neuronal network and cognitive function of PPT1KI mice	22
Tigecycline suppresses colon cancer stem cells and impairs tumor engraftment by targeting SNAI1-regulated epithelial-mesenchymal transition	22
Inhibition of Setd7 protects against cardiomyocyte hypertrophy via inhibiting lipid oxidation	22
Cardiac-specific deletion of BRG1 ameliorates ventricular arrhythmia in mice with myocardial infarction	22
A novel superior colliculus circuit mediates visual cue-driven methamphetamine taking and seeking	22
Neuropeptide-mediated activation of astrocytes improves stress resilience in mice by modulating cortical neural synapses	22
Notoginsenoside R1 protects against myocardial ischemia/reperfusion injury in mice via suppressing TAK1-JNK/p38 signaling	21
Selective inhibition of monoamine oxidase B represents a therapeutic strategy for diabetic peripheral neuropathy	21
Inhibition of HIF-prolyl hydroxylase promotes renal tubule regeneration via the reprogramming of renal proximal tubular cells	21
Cannabidiol inhibits both human KV7.1 and KV7.1/KCNE1 channels through distinct sites	21
Circular RNA hsa_circ_0000288 protects against epilepsy in mice by binding to and stabilizing caprin1 protein	21
Targeting BCL9/BCL9L enhances CD4+ T cell-mediated Th1 antitumor immunity through activation of STAT1/STAT4 signaling	21
Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis	21
The PIWI-interacting RNA CRAPIR alleviates myocardial ischemia‒reperfusion injury by reducing p53-mediated apoptosis via binding to SRSF1	21
BMP1 inhibitor UK383367 improves MI-induced cardiac remodeling and fibrosis in mice via ameliorating macrophage polarization and mitochondrial dysfunction	21
Adiponectin receptor agonist AdipoRon modulates human and mouse platelet function	20
RNF10 deficiency in cardiomyocytes impairs mitophagy and drives pathological hypertrophy	20
PHLDA1 contributes to hypoxic ischemic brain injury in neonatal rats via inhibiting FUNDC1-mediated mitophagy	20
Inhibition of CD36 ameliorates mouse spinal cord injury by accelerating microglial lipophagy	20
Dl-3-n-butylphthalide promotes angiogenesis in ischemic stroke mice through upregulating autocrine and paracrine sonic hedgehog	20
A sinomenine derivative protects life-threatening inflammatory injuries via covalently binding to a novel allosteric inhibition site of IRF3	20
Deep learning enables the discovery of a novel cuproptosis-inducing molecule for the inhibition of hepatocellular carcinoma	20
Brigatinib, a newly discovered AXL inhibitor, suppresses AXL-mediated acquired resistance to osimertinib in EGFR-mutated non-small cell lung cancer	20
Inhibiting the transcription and replication of Ebola viruses by disrupting the nucleoprotein and VP30 protein interaction with small molecules	19
A novel selective ERK1/2 inhibitor, Laxiflorin B, targets EGFR mutation subtypes in non-small-cell lung cancer	19
Aberrant neuronal excitation promotes neuroinflammation in the primary motor cortex of ischemic stroke mice	19
AI-enhanced virtual screening approach to hit identification for GluN1/GluN3A NMDA receptor	19
Cell death pathways and targeting therapeutics in cancer therapy	19
Thermoregulatory pathway underlying the pyrogenic effects of prostaglandin E2 in the lateral parabrachial nucleus of male rats	19
Discovery of FO-4-15, a novel 1,2,4-oxadiazole derivative, ameliorates cognitive impairments in 3×Tg mice by activating the mGluR1/CaMKIIα pathway	19
NADPHnet: a novel strategy to predict compounds for regulation of NADPH metabolism via network-based methods	19
Discovery of novel GluN1/GluN3A NMDA receptor inhibitors using a deep learning-based method	19
Indoleacrylic acid mitigates vascular rarefaction and enhances ischemia-induced neovascularization in aging via APLNR signaling	19
Pentapeptide PYRAE triggers ER stress-mediated apoptosis of breast cancer cells in mice by targeting RHBDF1-BiP interaction	19
Heat shock protein family A member 8 serving as a co-activator of transcriptional factor ETV4 up-regulates PHLDA2 to promote the growth of liver cancer	19
Decoding ligand recognition and constitutive activation of histamine H3 and H4 receptors	19
Asiatic acid promotes CD8+ T cell-mediated antitumor immunity by targeting HDAC8/CXCL10 axis in hepatocellular carcinoma	18
Advances in targeted therapies for pediatric tumors	18
An efficient deep learning-based strategy to screen inhibitors for GluN1/GluN3A receptor	18
Chemokine CCL2 promotes cardiac regeneration and repair in myocardial infarction mice via activation of the JNK/STAT3 axis	18
Serum granulosa cell-derived TNF-α promotes inflammation and apoptosis of renal tubular cells and PCOS-related kidney injury through NF-κB signaling	18
Colchicine reduces neointima formation and VSMC phenotype transition by modulating SRF-MYOCD activation and autophagy	18
Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson’s disease treatment	18
124I-labeled anti-CD147 antibody for noninvasive detection of CD147-positive pan-cancers: construction and preclinical studies	18
MMP-9 inhibitor SB-3CT improves neurological outcomes in ischemic stroke mice by modulation of astrocytic lipid metabolism	18
Formyl peptide receptor 2 is a potential biomarker and therapeutic target for inflammatory bowel disease	18
A novel small-molecule PCSK9 inhibitor E28362 ameliorates hyperlipidemia and atherosclerosis	17
Indoxyl sulphate-TNFα axis mediates uremic encephalopathy in rodent acute kidney injury	17
Disturbance of suprachiasmatic nucleus function improves cardiac repair after myocardial infarction by IGF2-mediated macrophage transition	17
6-Methyl flavone inhibits Nogo-B expression and improves high fructose diet-induced liver injury in mice	17
Deubiquitinating enzyme USP11 promotes renal tubular cell senescence and fibrosis via inhibiting the ubiquitin degradation of TGF-β receptor II	17
USP11 promotes renal tubular cell pyroptosis and fibrosis in UUO mice via inhibiting KLF4 ubiquitin degradation	17
HDAC inhibitor GCJ-490A modulates tumor microenvironment and synergizes with PD-1 antibody against breast and lung cancers in syngeneic murine models	17
α-MSH-catabolic enzyme prolylcarboxypeptidase in nucleus accumbens shell ameliorates stress susceptibility in mice through regulating synaptic plasticity	17
Role of thrombospondin-1 in high-salt–induced mesenteric artery endothelial impairment in rats	17
A structure-based virtual screening identifies a novel MDM2 antagonist in the activation of the p53 signaling and inhibition of tumor growth	17
Resibufogenin promotes angiogenesis via the VAV3-mediated ITGA5–VEGF signaling axis in macrophages to alleviate myocardial infarction	17
Ivacaftor, a CFTR potentiator, synergizes with osimertinib against acquired resistance to osimertinib in NSCLC by regulating CFTR-PTEN-AKT axis	17
ROS-induced degradation of hERG potassium channels contributes to aripiprazole-induced prolongation of the QTc interval	16
AI-driven breakthroughs in ion channel drug discovery: the future is now	16
GluD1 at the synaptic crossroads: from domain structure to circuit dysfunction	16
Roles and related underlying mechanisms of mitochondrial RNA modification in cancer progression	16
Targeting the 5-HT1B-YAP positive feedback loop protects against disturbed flow-induced atherogenesis in mice	16