Acta Pharmacologica Sinica

Article	Citations
Single-dose methamphetamine administration impairs ORM retrieval in mice via excessive DA-mediated inhibition of PrLGlu activity	303
Author Correction: Discovery of toxoflavin, a potent IRE1α inhibitor acting through structure-dependent oxidative inhibition	211
Reducing lipid peroxidation attenuates stress-induced susceptibility to herpes simplex virus type 1	157
Activating Wnt/β-catenin signaling by autophagic degradation of APC contributes to the osteoblast differentiation effect of soy isoflavone on osteoporotic mesenchymal stem cells	134
Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates	120
Identification of Licoflavone C as a cap-dependent endonuclease inhibitor against severe fever with thrombocytopenia syndrome virus	113
Translin deletion impairs cocaine-induced locomotor sensitization and RGS8 expression in the nucleus accumbens	112
MC1R and melanin-based molecular probes for theranostic of melanoma and beyond	104
Magnolin overcomes EGFR TKI resistance in NSCLC by modulation of NDRG1-NRG2-HECW1 pathway	99
Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition	96
Compound 38, a novel potent and selective antagonist of adenosine A2A receptor, enhances arousal in mice	94
S670, an amide derivative of 3-O-acetyl-11-keto-β-boswellic acid, induces ferroptosis in human glioblastoma cells by generating ROS and inhibiting STX17-mediated fusion of autophagosome and lysosome	87
Satellite cell-derived exosome-mediated delivery of microRNA-23a/27a/26a cluster ameliorates the renal tubulointerstitial fibrosis in mouse diabetic nephropathy	85
Celastrol suppresses the growth of vestibular schwannoma in mice by promoting the degradation of β-catenin	84
GRK2-mediated phosphorylation and de-succinylation of PKM2 reduce macrophage glycolysis in rheumatoid arthritis	84
Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren’s syndrome in mice by promoting TEC kinase degradation	82
tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis	76
Otilonium bromide ameliorates pulmonary fibrosis in mice through activating phosphatase PPM1A	75
Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson’s disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle	73
Cystathionine γ-lyase-derived H2S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase	70
Extracellular vesicles in vascular remodeling	69
Channelopathy of small- and intermediate-conductance Ca2+-activated K+ channels	68
Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-κB p65-activated SLC7A11 transcription	65
Pyroptosis and pyroptosis-inducing cancer drugs	65
Natural product-based screening led to the discovery of a novel PXR agonist with anti-cholestasis activity	64

The hybrid oncolytic peptide NTP-385 potently inhibits adherent cancer cells by targeting the nucleus	64
Targeted degradation of membrane and extracellular proteins with LYTACs	63
Transport mechanism and drug discovery of human monocarboxylate transporter 1	62
Correction to: EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells	61
Author Correction: ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway	61
Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation	60
Resibufogenin ameliorates cerebral ischemia-reperfusion injury by modulating microglial redox homeostasis via Keap1-Nrf2-TFR1/ARE axis	59
p52-ZER6: a determinant of tumor cell sensitivity to MDM2-p53 binding inhibitors	56
143D, a novel selective KRASG12C inhibitor exhibits potent antitumor activity in preclinical models	55
Insomnia-related rodent models in drug discovery	55
Retraction Note: Physcion inhibits the metastatic potential of human colorectal cancer SW620 cells in vitro by suppressing the transcription factor SOX2	54
Transcriptional regulation and small compound targeting of ACE2 in lung epithelial cells	52
Thoracic perivascular adipose tissue inhibits VSMC apoptosis and aortic aneurysm formation in mice via the secretome of browning adipocytes	51
Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376	51
Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer	51
Sortilin deletion in the prefrontal cortex and hippocampus ameliorates depressive-like behaviors in mice via regulating ASM/ceramide signaling	51
Antagonism of histamine H3 receptor promotes angiogenesis following focal cerebral ischemia	50
LN-439A, a novel BAP1 inhibitor, suppresses the growth of basal-like breast cancer by degrading KLF5	49
Liver X receptor inverse agonist SR9243 attenuates rheumatoid arthritis via modulating glycolytic metabolism of macrophages	48
Gastrodin promotes CNS myelinogenesis and alleviates demyelinating injury by activating the PI3K/AKT/mTOR signaling	48
Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial calcium-mediated renal tubular cell senescence	46
Chronic infusion of ELABELA alleviates vascular remodeling in spontaneously hypertensive rats via anti-inflammatory, anti-oxidative and anti-proliferative effects	45
FX5, a non-steroidal glucocorticoid receptor antagonist, ameliorates diabetic cognitive impairment in mice	45
Exploring the distinct activation mechanisms of neuromedin B receptor through multiple replica molecular dynamics simulations and Markov state modeling	44
TRADD-mediated pyroptosis contributes to diabetic cardiomyopathy	44
Dual-responsive nanoparticles loading bevacizumab and gefitinib for molecular targeted therapy against non-small cell lung cancer	42
Correction: Chemokine CCL2 promotes cardiac regeneration and repair in myocardial infarction mice via activation of the JNK/STAT3 axis	41
Dendritic cell-liposome conjugates reverse immunosuppressive tumor microenvironment for inhibiting colitis-associated colorectal cancer	41
DNMT inhibition epigenetically restores the cGAS-STING pathway and activates RIG-I/MDA5-MAVS to enhance antitumor immunity	41
Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway	41
Krüppel-like factor 15 ameliorates alcohol-induced liver injury in mice via regulation of the PFKFB3/AKT axis	40
Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol	40
Author Correction: Anti-diabetic drug canagliflozin hinders skeletal muscle regeneration in mice	40
Fangchinoline-mediated autophagy inhibition amplifies antigen presentation and PD-1 blockade efficacy in lung cancer	40
Chemistry and bioactivity of secondary metabolites from South China Sea marine fauna and flora: recent research advances and perspective	39
A high-throughput screening campaign against PFKFB3 identified potential inhibitors with novel scaffolds	39
RIPK1 inhibition contributes to lysosomal membrane stabilization in ischemic astrocytes via a lysosomal Hsp70.1B-dependent mechanism	38
14-3-3ζ inhibits maladaptive repair in renal tubules by regulating YAP and reduces renal interstitial fibrosis	38
Methionine-choline deficient diet deteriorates DSS-induced murine colitis through disturbance of gut microbes and infiltration of macrophages	38
Selumetinib promotes coronary collateral circulation by inducing M2-like macrophage polarization following myocardial infarction	38
Mitofusin-2 mediates cannabidiol-induced neuroprotection against cerebral ischemia in rats	37
Preclinical characterization of [18F]D2-LW223: an improved metabolically stable PET tracer for imaging the translocator protein 18 kDa (TSPO) in neuroinflammatory rodent models and non-human primates	37
NASH: regulatory considerations for clinical drug development and U.S. FDA approval	37
SGLT2 inhibitor empagliflozin promotes revascularization in diabetic mouse hindlimb ischemia by inhibiting ferroptosis	37
Melatonin ameliorates bleomycin-induced pulmonary fibrosis via activating NRF2 and inhibiting galectin-3 expression	37
Advances in cannabinoid receptors pharmacology: from receptor structural insights to ligand discovery	36
SAAINT-DB: a comprehensive structural antibody database for antibody modeling and design	36
JOSD2 alleviates acute kidney injury through deubiquitinating SIRT7 and negativity regulating SIRT7-NF-κB inflammatory pathway in renal tubular epithelial cells	36
Regulation of toll-like receptor (TLR) signaling pathways in atherosclerosis: from mechanisms to targeted therapeutics	36
Selective EZH2 inhibitor zld1039 alleviates inflammation in cisplatin-induced acute kidney injury partially by enhancing RKIP and suppressing NF-κB p65 pathway	36

The diverse role of the raphe 5-HTergic systems in epilepsy	35
Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy	35
Celastrol attenuates hepatitis C virus translation and inflammatory response in mice by suppressing heat shock protein 90β	35
Porcupine inhibitor CGX1321 alleviates heart failure with preserved ejection fraction in mice by blocking WNT signaling	35
AlphaFold3 versus experimental structures: assessment of the accuracy in ligand-bound G protein-coupled receptors	35
Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated fatty liver disease in mice: potential involvement of PANoptosis	34
Contrastive learning-based drug screening model for GluN1/GluN3A inhibitors	34
Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells	33
Z16b, a natural compound from Ganoderma cochlear is a novel RyR2 stabilizer preventing catecholaminergic polymorphic ventricular tachycardia	33
Molecular recognition of two approved drugs Macimorelin and Anamorelin by the growth hormone secretagogue receptor	33
CP-25 enhances OAT1-mediated absorption of methotrexate in synoviocytes of collagen-induced arthritis rats	33
Circular RNA circDhx32 promotes cardiac inflammatory responses in mouse cardiac ischemia-reperfusion injury via binding to FOXO1 competed with AdipoR1	33
NADPH acts as an endogenous P2X7 receptor modulator to gate neuroinflammatory responses of microglia	33
Co-inhibition of RAGE and TLR4 sensitizes pancreatic cancer to irreversible electroporation in mice by disrupting autophagy	32
Current status and challenges in the drug treatment for fibrotic nonalcoholic steatohepatitis	32
Endothelial dysfunction: mechanisms and contribution to diseases	32
Therapeutic potential and pharmacological mechanisms of Traditional Chinese Medicine in gout treatment	32
Skullcapflavone II, a novel NQO1 inhibitor, alleviates aristolochic acid I-induced liver and kidney injury in mice	32
Scutellarin suppresses triple-negative breast cancer metastasis by inhibiting TNFα-induced vascular endothelial barrier breakdown	31
Proteomic characterization of post-translational modifications in drug discovery	31
ROCK1 inhibition improves wound healing in diabetes via RIPK4/AMPK pathway	31
Phenethyl isothiocyanate inhibits metastasis potential of non-small cell lung cancer cells through FTO mediated TLE1 m6A modification	31
Wogonin attenuates septic cardiomyopathy by suppressing ALOX15-mediated ferroptosis	31
Cardiomyocyte peroxisome proliferator-activated receptor α prevents septic cardiomyopathy via improving mitochondrial function	30
Identifying a non-conserved site for achieving allosteric covalent inhibition of CECR2	30
Esculetin facilitates post-stroke rehabilitation by inhibiting CKLF1-mediated neutrophil infiltration	30
Author Correction: Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis	29
Adaptor protein Src-homology 2 domain containing E (SH2E) deficiency induces heart defect in zebrafish	29
Discovery of a nitroaromatic nannocystin with potent in vivo anticancer activity against colorectal cancer by targeting AKT1	29
Thioridazine protects against disturbed flow-induced atherosclerosis by inhibiting RhoA/YAP-mediated endothelial inflammation	29
Dorsal raphe GABA-ergic neurons regulate the susceptibility to social transfer of pain in mice	29
(+)-Borneol enantiomer ameliorates epileptic seizure via decreasing the excitability of glutamatergic transmission	29
Dehydrocorydaline maintains the vascular smooth muscle cell contractile phenotype by upregulating Spta1	28
HER3 upregulation reduces DS-8201 sensitivity in HER2-positive tumor cells by ATR/CHK1/FoxO1 signaling cascade	28
Electrophysiological characterization of human KCNT1 channel modulators and the therapeutic potential of hydroquinine and tipepidine in KCNT1 mutation-associated epilepsy mouse model	28
Development of orthotopic mouse models for mid-low rectal cancer	28
Revisiting the role of GDF15 in atherosclerosis in mouse and human	28
Anti-diabetic drug canagliflozin hinders skeletal muscle regeneration in mice	27
Celastrol inhibits the DPYSL2-JAK/STAT pathway by targeting mito-IDHs mediated mitochondrial metabolism to exhaust breast cancer	27
Sirtuin 6 mitigates thoracic aortic aneurysm progression via maintenance of mitochondria homeostasis in vascular smooth muscle cells	27
Caffeic acid phenethyl ester suppresses intestinal FXR signaling and ameliorates nonalcoholic fatty liver disease by inhibiting bacterial bile salt hydrolase activity	27
Development of PI3Kγ selective inhibitors: the strategies and application	27
Novel treatment for refractory rheumatoid arthritis with total glucosides of paeony and nobiletin codelivered in a self-nanoemulsifying drug delivery system	27
Inhibiting mPGES-2 impedes renal cyst growth in mice with polycystic kidney disease	27
Aspirin modulates succinylation of PGAM1K99 to restrict the glycolysis through NF-κB/HAT1/PGAM1 signaling in liver cancer	27
Correction: Empagliflozin and liraglutide ameliorate HFpEF in mice via augmenting the Erbb4 signaling pathway	27
PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours	27
c-FLIP promotes drug resistance in non-small-cell lung cancer cells via upregulating FoxM1 expression	27
Cardiovascular adverse effects of antiviral therapies for COVID-19: Evidence and plausible mechanisms	26
NFAT inhibitor 11R-VIVIT ameliorates mouse renal fibrosis after ischemia-reperfusion-induced acute kidney injury	26
Bile acid and receptors: biology and drug discovery for nonalcoholic fatty liver disease	26
GFPBW1, a β-glucan from Grifola frondosa as vaccine adjuvant: APCs activation and maturation	26
Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases	25
G-protein coupled receptor kinase 2 mediates rheumatoid arthritis-induced depression-like behaviors via the hippocampal CRHR1 signaling pathway	25
Peptidoglycan isolated from the fruit of Lycium barbarum alleviates liver fibrosis in mice by regulating the TGF-β/Smad7 signaling and gut microbiota	25
zDHHC20-driven S-palmitoylation of CD80 is required for its costimulatory function	25
Targeting PI3Kα overcomes resistance to KRasG12C inhibitors mediated by activation of EGFR and/or IGF1R	25
Serum amyloid A3 aggravates bleomycin-induced pulmonary fibrosis through Krüppel-like factor 6-dependent interlukin-36α expression	25
The role of microglia in neurodegenerative diseases: from the perspective of ferroptosis	25
Atypical chemokine receptor 3 induces colorectal tumorigenesis in mice by promoting β-arrestin-NOLC1-fibrillarin-dependent rRNA biogenesis	24
Prenatal dexamethasone exposure impairs rat blood-testis barrier function and sperm quality in adult offspring via GR/KDM1B/FSTL3/TGFβ signaling	24
Asiatic acid ameliorates doxorubicin-induced cardiotoxicity by promoting FPN-mediated iron export and inhibiting ferroptosis	24
Chronic β-adrenergic stress contributes to cardiomyopathy in rodents with collagen-induced arthritis	24
Author Correction: Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance	24
Poria cocos: traditional uses, triterpenoid components and their renoprotective pharmacology	24
Betaine-homocysteine methyltransferase protects against acetaminophen-induced acute liver failure via BACH1-SCD1-oleic acid axis	24
Endothelial deubiquinatase YOD1 mediates Ang II-induced vascular endothelial-mesenchymal transition and remodeling by regulating β-catenin	24
Luteolin ameliorates chronic stress-induced depressive-like behaviors in mice by promoting the Arginase-1+ microglial phenotype via a PPARγ-dependent mechanism	23
Inhibiting the Otub1/phosphorylated STAT3 axis for the treatment of non-small cell lung cancer	23
Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway	23
Cyclic GMP-AMP synthase recognizes the physical features of DNA	23
Novel insights into NOD-like receptors in renal diseases	23
Pharmacological inhibition of FABP7 by MF 6 counteracts cerebellum dysfunction in an experimental multiple system atrophy mouse model	23
Hypocrellin A from an ethnic medicinal fungus protects against NLRP3-driven gout in mice by suppressing inflammasome activation	23
Targeted VEGFA therapy in regulating early acute kidney injury and late fibrosis	22
Exploring the constitutive activation mechanism of the class A orphan GPR20	22
Multifaceted roles of UFMylation in health and disease	22
AXL antibody and AXL-ADC mediate antitumor efficacy via targeting AXL in tumor-intrinsic epithelial-mesenchymal transition and tumor-associated M2-like macrophage	22
GPR41 deficiency aggravates type 1 diabetes in streptozotocin-treated mice by promoting dendritic cell maturation	22
Targeting cholesterol metabolism: a promising therapy strategy for cancer	22

Urolithin A ameliorates obesity-induced metabolic cardiomyopathy in mice via mitophagy activation	22
DZ2002 alleviates corneal angiogenesis and inflammation in rodent models of dry eye disease via regulating STAT3-PI3K-Akt-NF-κB pathway	22
Gentiopicroside ameliorates psoriasis-like skin lesions in mice via regulating the Keap1-Nrf2 pathway and inhibiting keratinocyte activation	22
Inhibition of HIF-prolyl hydroxylase promotes renal tubule regeneration via the reprogramming of renal proximal tubular cells	21
Activation of D2-like dopamine receptors improves the neuronal network and cognitive function of PPT1KI mice	21
The PIWI-interacting RNA CRAPIR alleviates myocardial ischemia‒reperfusion injury by reducing p53-mediated apoptosis via binding to SRSF1	21
Correction: A novel annexin dimer targets microglial phagocytosis of astrocytes to protect the brain-blood barrier after cerebral ischemia	21
Neuropeptide-mediated activation of astrocytes improves stress resilience in mice by modulating cortical neural synapses	21
Brigatinib, a newly discovered AXL inhibitor, suppresses AXL-mediated acquired resistance to osimertinib in EGFR-mutated non-small cell lung cancer	21
Inhibition of Setd7 protects against cardiomyocyte hypertrophy via inhibiting lipid oxidation	21
Inhibition of CD36 ameliorates mouse spinal cord injury by accelerating microglial lipophagy	21
GluN2A-NMDA receptor inhibition disinhibits the prefrontal cortex, reduces forced swim immobility, and impairs sensorimotor gating	21
Tigecycline suppresses colon cancer stem cells and impairs tumor engraftment by targeting SNAI1-regulated epithelial-mesenchymal transition	21
Discovery of FO-4-15, a novel 1,2,4-oxadiazole derivative, ameliorates cognitive impairments in 3×Tg mice by activating the mGluR1/CaMKIIα pathway	20
Pentapeptide PYRAE triggers ER stress-mediated apoptosis of breast cancer cells in mice by targeting RHBDF1-BiP interaction	20
BMP1 inhibitor UK383367 improves MI-induced cardiac remodeling and fibrosis in mice via ameliorating macrophage polarization and mitochondrial dysfunction	20
PHLDA1 contributes to hypoxic ischemic brain injury in neonatal rats via inhibiting FUNDC1-mediated mitophagy	20
NADPHnet: a novel strategy to predict compounds for regulation of NADPH metabolism via network-based methods	20
Notoginsenoside R1 protects against myocardial ischemia/reperfusion injury in mice via suppressing TAK1-JNK/p38 signaling	20
GLP-1 mimetics as a potential therapy for nonalcoholic steatohepatitis	20
Somatostatin receptor 2 targeting peptide modifications for peptide-drug conjugate treatment of small cell lung cancer	20
Updates on novel pharmacotherapeutics for the treatment of nonalcoholic steatohepatitis	20
Decoding ligand recognition and constitutive activation of histamine H3 and H4 receptors	20
Adiponectin receptor agonist AdipoRon modulates human and mouse platelet function	20
ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway	20
Circular RNA hsa_circ_0000288 protects against epilepsy in mice by binding to and stabilizing caprin1 protein	20
Deep learning enables the discovery of a novel cuproptosis-inducing molecule for the inhibition of hepatocellular carcinoma	20
Thermoregulatory pathway underlying the pyrogenic effects of prostaglandin E2 in the lateral parabrachial nucleus of male rats	20
Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson’s disease treatment	20
Differential modulation of subthalamic projection neurons by short-term and long-term electrical stimulation in physiological and parkinsonian conditions	20
Cardiac-specific deletion of BRG1 ameliorates ventricular arrhythmia in mice with myocardial infarction	20
Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis	20
Modeling exposure-driven adverse events of EGFR TKIs in the treatment of patients with non-small cell lung cancer	20
Characterization of LTr1 derived from cruciferous vegetables as a novel anti-glioma agent via inhibiting TrkA/PI3K/AKT pathway	20
Dl-3-n-butylphthalide promotes angiogenesis in ischemic stroke mice through upregulating autocrine and paracrine sonic hedgehog	20
Tetramethylpyrazine prevents liver fibrotic injury in mice by targeting hepatocyte-derived and mitochondrial DNA-enriched extracellular vesicles	19
Novel Caspase-1 inhibitor CZL80 improves neurological function in mice after progressive ischemic stroke within a long therapeutic time-window	19
Indoxyl sulphate-TNFα axis mediates uremic encephalopathy in rodent acute kidney injury	19
Formyl peptide receptor 2 is a potential biomarker and therapeutic target for inflammatory bowel disease	19
Chemokine CCL2 promotes cardiac regeneration and repair in myocardial infarction mice via activation of the JNK/STAT3 axis	19
Deubiquitinating enzyme USP11 promotes renal tubular cell senescence and fibrosis via inhibiting the ubiquitin degradation of TGF-β receptor II	19
Dihydroartemisinin suppresses renal fibrosis in mice by inhibiting DNA-methyltransferase 1 and increasing Klotho	19
Inhibiting the transcription and replication of Ebola viruses by disrupting the nucleoprotein and VP30 protein interaction with small molecules	19
Aberrant neuronal excitation promotes neuroinflammation in the primary motor cortex of ischemic stroke mice	19
Heat shock protein family A member 8 serving as a co-activator of transcriptional factor ETV4 up-regulates PHLDA2 to promote the growth of liver cancer	19
124I-labeled anti-CD147 antibody for noninvasive detection of CD147-positive pan-cancers: construction and preclinical studies	18
A novel selective ERK1/2 inhibitor, Laxiflorin B, targets EGFR mutation subtypes in non-small-cell lung cancer	18
Role of thrombospondin-1 in high-salt–induced mesenteric artery endothelial impairment in rats	18
Discovery of novel GluN1/GluN3A NMDA receptor inhibitors using a deep learning-based method	18
Liver receptor homolog-1: structures, related diseases, and drug discovery	18
Serum granulosa cell-derived TNF-α promotes inflammation and apoptosis of renal tubular cells and PCOS-related kidney injury through NF-κB signaling	18
A novel small-molecule PCSK9 inhibitor E28362 ameliorates hyperlipidemia and atherosclerosis	18
AI-enhanced virtual screening approach to hit identification for GluN1/GluN3A NMDA receptor	18
α-MSH-catabolic enzyme prolylcarboxypeptidase in nucleus accumbens shell ameliorates stress susceptibility in mice through regulating synaptic plasticity	18
USP11 promotes renal tubular cell pyroptosis and fibrosis in UUO mice via inhibiting KLF4 ubiquitin degradation	18
Colchicine reduces neointima formation and VSMC phenotype transition by modulating SRF-MYOCD activation and autophagy	18
MMP-9 inhibitor SB-3CT improves neurological outcomes in ischemic stroke mice by modulation of astrocytic lipid metabolism	18
An efficient deep learning-based strategy to screen inhibitors for GluN1/GluN3A receptor	18
A structure-based virtual screening identifies a novel MDM2 antagonist in the activation of the p53 signaling and inhibition of tumor growth	17
Norcantharidin promotes M1 macrophage polarization and suppresses colorectal cancer growth	17
Targeting the 5-HT1B-YAP positive feedback loop protects against disturbed flow-induced atherogenesis in mice	17
Disturbance of suprachiasmatic nucleus function improves cardiac repair after myocardial infarction by IGF2-mediated macrophage transition	17
Ivacaftor, a CFTR potentiator, synergizes with osimertinib against acquired resistance to osimertinib in NSCLC by regulating CFTR-PTEN-AKT axis	17
TGFβR-1/ALK5 inhibitor RepSox induces enteric glia-to-neuron transition and influences gastrointestinal mobility in adult mice	17
YY1/HIF-1α/mROS positive-feedback loop exacerbates glomerular mesangial cell proliferation in mouse early diabetic kidney disease	17
The aminosteroid U73122 promotes oligodendrocytes generation and myelin formation	17
ROS-induced degradation of hERG potassium channels contributes to aripiprazole-induced prolongation of the QTc interval	17