Acta Pharmacologica Sinica

Article	Citations
Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren’s syndrome in mice by promoting TEC kinase degradation	236
Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition	142
Author Correction: Discovery of toxoflavin, a potent IRE1α inhibitor acting through structure-dependent oxidative inhibition	121
Natural product-based screening led to the discovery of a novel PXR agonist with anti-cholestasis activity	119
Celastrol suppresses the growth of vestibular schwannoma in mice by promoting the degradation of β-catenin	101
Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson’s disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle	95
Single-dose methamphetamine administration impairs ORM retrieval in mice via excessive DA-mediated inhibition of PrLGlu activity	92
Reducing lipid peroxidation attenuates stress-induced susceptibility to herpes simplex virus type 1	91
Identification of Licoflavone C as a cap-dependent endonuclease inhibitor against severe fever with thrombocytopenia syndrome virus	85
Activating Wnt/β-catenin signaling by autophagic degradation of APC contributes to the osteoblast differentiation effect of soy isoflavone on osteoporotic mesenchymal stem cells	84
ADT-OH inhibits malignant melanoma metastasis in mice via suppressing CSE/CBS and FAK/Paxillin signaling pathway	84
Otilonium bromide ameliorates pulmonary fibrosis in mice through activating phosphatase PPM1A	82
Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates	78
Satellite cell-derived exosome-mediated delivery of microRNA-23a/27a/26a cluster ameliorates the renal tubulointerstitial fibrosis in mouse diabetic nephropathy	75
Channelopathy of small- and intermediate-conductance Ca2+-activated K+ channels	74
Cystathionine γ-lyase-derived H2S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase	74
Role of TRPM2 in brain tumours and potential as a drug target	73
Extracellular vesicles in vascular remodeling	73
MC1R and melanin-based molecular probes for theranostic of melanoma and beyond	72
Compound 38, a novel potent and selective antagonist of adenosine A2A receptor, enhances arousal in mice	72
Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-κB p65-activated SLC7A11 transcription	65
Paris saponin VII, a Hippo pathway activator, induces autophagy and exhibits therapeutic potential against human breast cancer cells	64
Targeted degradation of membrane and extracellular proteins with LYTACs	62
The hybrid oncolytic peptide NTP-385 potently inhibits adherent cancer cells by targeting the nucleus	59
S670, an amide derivative of 3-O-acetyl-11-keto-β-boswellic acid, induces ferroptosis in human glioblastoma cells by generating ROS and inhibiting STX17-mediated fusion of autophagosome and lysosome	58

tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis	56
Pyroptosis and pyroptosis-inducing cancer drugs	56
Gastrodin promotes CNS myelinogenesis and alleviates demyelinating injury by activating the PI3K/AKT/mTOR signaling	55
Transport mechanism and drug discovery of human monocarboxylate transporter 1	53
Upregulation of wild-type p53 by small molecule-induced elevation of NQO1 in non-small cell lung cancer cells	53
Flavokawain B alleviates LPS-induced acute lung injury via targeting myeloid differentiation factor 2	53
Antagonism of histamine H3 receptor promotes angiogenesis following focal cerebral ischemia	53
Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer	51
FX5, a non-steroidal glucocorticoid receptor antagonist, ameliorates diabetic cognitive impairment in mice	51
Liver X receptor inverse agonist SR9243 attenuates rheumatoid arthritis via modulating glycolytic metabolism of macrophages	50
Transcriptional regulation and small compound targeting of ACE2 in lung epithelial cells	50
Author Correction: ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway	49
Chronic infusion of ELABELA alleviates vascular remodeling in spontaneously hypertensive rats via anti-inflammatory, anti-oxidative and anti-proliferative effects	48
143D, a novel selective KRASG12C inhibitor exhibits potent antitumor activity in preclinical models	48
LN-439A, a novel BAP1 inhibitor, suppresses the growth of basal-like breast cancer by degrading KLF5	48
Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376	48
Identification of pimavanserin tartrate as a potent Ca2+-calcineurin-NFAT pathway inhibitor for glioblastoma therapy	46
Insomnia-related rodent models in drug discovery	46
Correction to: EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells	46
Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation	45
p52-ZER6: a determinant of tumor cell sensitivity to MDM2-p53 binding inhibitors	44
Furmonertinib (Alflutinib, AST2818) is a potential positive control drug comparable to rifampin for evaluation of CYP3A4 induction in sandwich-cultured primary human hepatocytes	44
TRADD-mediated pyroptosis contributes to diabetic cardiomyopathy	43
Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial calcium-mediated renal tubular cell senescence	42
Bispecific antibody simultaneously targeting PD1 and HER2 inhibits tumor growth via direct tumor cell killing in combination with PD1/PDL1 blockade and HER2 inhibition	41
Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway	40
Benzimidazoles induce concurrent apoptosis and pyroptosis of human glioblastoma cells via arresting cell cycle	40
Dual-responsive nanoparticles loading bevacizumab and gefitinib for molecular targeted therapy against non-small cell lung cancer	40
Thoracic perivascular adipose tissue inhibits VSMC apoptosis and aortic aneurysm formation in mice via the secretome of browning adipocytes	39
Sortilin deletion in the prefrontal cortex and hippocampus ameliorates depressive-like behaviors in mice via regulating ASM/ceramide signaling	38
Kanglexin delays heart aging by promoting mitophagy	38
JOSD2 alleviates acute kidney injury through deubiquitinating SIRT7 and negativity regulating SIRT7-NF-κB inflammatory pathway in renal tubular epithelial cells	38
Author Correction: Anti-diabetic drug canagliflozin hinders skeletal muscle regeneration in mice	38
Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol	37
RIPK1 inhibition contributes to lysosomal membrane stabilization in ischemic astrocytes via a lysosomal Hsp70.1B-dependent mechanism	37
Mitofusin-2 mediates cannabidiol-induced neuroprotection against cerebral ischemia in rats	36
NASH: regulatory considerations for clinical drug development and U.S. FDA approval	35
Discovery of novel MIF inhibitors that attenuate microglial inflammatory activation by structures-based virtual screening and in vitro bioassays	35
Discovery of novel DprE1 inhibitors via computational bioactivity fingerprints and structure-based virtual screening	34
Celastrol attenuates hepatitis C virus translation and inflammatory response in mice by suppressing heat shock protein 90β	34
Antiatherosclerotic effect of dehydrocorydaline on ApoE−/− mice: inhibition of macrophage inflammation	34
AlphaFold3 versus experimental structures: assessment of the accuracy in ligand-bound G protein-coupled receptors	33
Fangchinoline-mediated autophagy inhibition amplifies antigen presentation and PD-1 blockade efficacy in lung cancer	33
The diverse role of the raphe 5-HTergic systems in epilepsy	32
Deletion of p38γ attenuates ethanol consumption- and acetaminophen-induced liver injury in mice through promoting Dlg1	32
Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy	32
Chemistry and bioactivity of secondary metabolites from South China Sea marine fauna and flora: recent research advances and perspective	32
Melatonin ameliorates bleomycin-induced pulmonary fibrosis via activating NRF2 and inhibiting galectin-3 expression	32
14-3-3ζ inhibits maladaptive repair in renal tubules by regulating YAP and reduces renal interstitial fibrosis	31
A high-throughput screening campaign against PFKFB3 identified potential inhibitors with novel scaffolds	31

ATF3 contributes to brucine-triggered glioma cell ferroptosis via promotion of hydrogen peroxide and iron	31
Methionine-choline deficient diet deteriorates DSS-induced murine colitis through disturbance of gut microbes and infiltration of macrophages	31
Correction: Chemokine CCL2 promotes cardiac regeneration and repair in myocardial infarction mice via activation of the JNK/STAT3 axis	31
Porcupine inhibitor CGX1321 alleviates heart failure with preserved ejection fraction in mice by blocking WNT signaling	30
Exogenous glutathione exerts a therapeutic effect in ischemic stroke rats by interacting with intrastriatal dopamine	29
Selumetinib promotes coronary collateral circulation by inducing M2-like macrophage polarization following myocardial infarction	29
Advances in cannabinoid receptors pharmacology: from receptor structural insights to ligand discovery	29
Preclinical characterization of [18F]D2-LW223: an improved metabolically stable PET tracer for imaging the translocator protein 18 kDa (TSPO) in neuroinflammatory rodent models and non-human primates	29
Selective EZH2 inhibitor zld1039 alleviates inflammation in cisplatin-induced acute kidney injury partially by enhancing RKIP and suppressing NF-κB p65 pathway	29
Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated fatty liver disease in mice: potential involvement of PANoptosis	28
Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein	28
Regulation of toll-like receptor (TLR) signaling pathways in atherosclerosis: from mechanisms to targeted therapeutics	28
CP-25 enhances OAT1-mediated absorption of methotrexate in synoviocytes of collagen-induced arthritis rats	28
SGLT2 inhibitor empagliflozin promotes revascularization in diabetic mouse hindlimb ischemia by inhibiting ferroptosis	28
Current status and challenges in the drug treatment for fibrotic nonalcoholic steatohepatitis	27
ML365 inhibits TWIK2 channel to block ATP-induced NLRP3 inflammasome	27
Phenethyl isothiocyanate inhibits metastasis potential of non-small cell lung cancer cells through FTO mediated TLE1 m6A modification	27
Co-inhibition of RAGE and TLR4 sensitizes pancreatic cancer to irreversible electroporation in mice by disrupting autophagy	27
Esculetin facilitates post-stroke rehabilitation by inhibiting CKLF1-mediated neutrophil infiltration	27
Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells	26
Proteomic characterization of post-translational modifications in drug discovery	26
Scutellarin suppresses triple-negative breast cancer metastasis by inhibiting TNFα-induced vascular endothelial barrier breakdown	26
Wogonin attenuates septic cardiomyopathy by suppressing ALOX15-mediated ferroptosis	26
Hypertrophic preconditioning attenuates post-myocardial infarction injury through deacetylation of isocitrate dehydrogenase 2	26
Dezocine as a potent analgesic: overview of its pharmacological characterization	25
Therapeutic potential and pharmacological mechanisms of Traditional Chinese Medicine in gout treatment	25
Cardiomyocyte peroxisome proliferator-activated receptor α prevents septic cardiomyopathy via improving mitochondrial function	25
Endothelial dysfunction: mechanisms and contribution to diseases	25
Z16b, a natural compound from Ganoderma cochlear is a novel RyR2 stabilizer preventing catecholaminergic polymorphic ventricular tachycardia	25
Identifying a non-conserved site for achieving allosteric covalent inhibition of CECR2	25
Long-term running exercise alleviates cognitive dysfunction in APP/PSEN1 transgenic mice via enhancing brain lysosomal function	25
Skullcapflavone II, a novel NQO1 inhibitor, alleviates aristolochic acid I-induced liver and kidney injury in mice	24
Discovery of a nitroaromatic nannocystin with potent in vivo anticancer activity against colorectal cancer by targeting AKT1	24
zDHHC20-driven S-palmitoylation of CD80 is required for its costimulatory function	24
Estrogen-dependent KCa1.1 modulation is essential for retaining neuroexcitation of female-specific subpopulation of myelinated Ah-type baroreceptor neurons in rats	24
ROCK1 inhibition improves wound healing in diabetes via RIPK4/AMPK pathway	24
Development of PI3Kγ selective inhibitors: the strategies and application	24
Anti-diabetic drug canagliflozin hinders skeletal muscle regeneration in mice	23
Cardiovascular adverse effects of antiviral therapies for COVID-19: Evidence and plausible mechanisms	23
Adaptor protein Src-homology 2 domain containing E (SH2E) deficiency induces heart defect in zebrafish	23
c-FLIP promotes drug resistance in non-small-cell lung cancer cells via upregulating FoxM1 expression	23
Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates	23
Author Correction: Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis	22
Development of orthotopic mouse models for mid-low rectal cancer	22
PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours	22
Thioridazine protects against disturbed flow-induced atherosclerosis by inhibiting RhoA/YAP-mediated endothelial inflammation	22
Bergenin, a PPARγ agonist, inhibits Th17 differentiation and subsequent neutrophilic asthma by preventing GLS1-dependent glutaminolysis	22
NFAT inhibitor 11R-VIVIT ameliorates mouse renal fibrosis after ischemia-reperfusion-induced acute kidney injury	22
GFPBW1, a β-glucan from Grifola frondosa as vaccine adjuvant: APCs activation and maturation	22
The novel indomethacin derivative CZ-212-3 exerts antitumor effects on castration-resistant prostate cancer by degrading androgen receptor and its variants	22
Aspirin modulates succinylation of PGAM1K99 to restrict the glycolysis through NF-κB/HAT1/PGAM1 signaling in liver cancer	22
Asiatic acid ameliorates doxorubicin-induced cardiotoxicity by promoting FPN-mediated iron export and inhibiting ferroptosis	21
Targeting PI3Kα overcomes resistance to KRasG12C inhibitors mediated by activation of EGFR and/or IGF1R	21
Poria cocos: traditional uses, triterpenoid components and their renoprotective pharmacology	21
Ainsliadimer C, a disesquiterpenoid isolated from Ainsliaea macrocephala, ameliorates inflammatory responses in adipose tissue via Sirtuin 1-NLRP3 inflammasome axis	21
(+)-Borneol enantiomer ameliorates epileptic seizure via decreasing the excitability of glutamatergic transmission	21
Celastrol inhibits the DPYSL2-JAK/STAT pathway by targeting mito-IDHs mediated mitochondrial metabolism to exhaust breast cancer	21
Peptidoglycan isolated from the fruit of Lycium barbarum alleviates liver fibrosis in mice by regulating the TGF-β/Smad7 signaling and gut microbiota	21
Correction: Empagliflozin and liraglutide ameliorate HFpEF in mice via augmenting the Erbb4 signaling pathway	21
Endothelial deubiquinatase YOD1 mediates Ang II-induced vascular endothelial-mesenchymal transition and remodeling by regulating β-catenin	21
Dorsal raphe GABA-ergic neurons regulate the susceptibility to social transfer of pain in mice	21
Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases	20
The role of microglia in neurodegenerative diseases: from the perspective of ferroptosis	20
Effect of autoinduction and food on the pharmacokinetics of furmonertinib and its active metabolite characterized by a population pharmacokinetic model	20
Novel treatment for refractory rheumatoid arthritis with total glucosides of paeony and nobiletin codelivered in a self-nanoemulsifying drug delivery system	20
IFN-α inhibits HBV transcription and replication by promoting HDAC3-mediated de-2-hydroxyisobutyrylation of histone H4K8 on HBV cccDNA minichromosome in liver	20
Caffeic acid phenethyl ester suppresses intestinal FXR signaling and ameliorates nonalcoholic fatty liver disease by inhibiting bacterial bile salt hydrolase activity	20
Electrophysiological characterization of human KCNT1 channel modulators and the therapeutic potential of hydroquinine and tipepidine in KCNT1 mutation-associated epilepsy mouse model	20
Dehydrocorydaline maintains the vascular smooth muscle cell contractile phenotype by upregulating Spta1	20
Bile acid and receptors: biology and drug discovery for nonalcoholic fatty liver disease	20
Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway	19
Atypical chemokine receptor 3 induces colorectal tumorigenesis in mice by promoting β-arrestin-NOLC1-fibrillarin-dependent rRNA biogenesis	19
Age-dependent alterations in key components of the nigrostriatal dopaminergic system and distinct motor phenotypes	19
Chronic β-adrenergic stress contributes to cardiomyopathy in rodents with collagen-induced arthritis	19
Targeting cholesterol metabolism: a promising therapy strategy for cancer	19
Targeting cyclin-dependent kinase 9 in cancer therapy	19
Author Correction: Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance	19
Inhibiting the Otub1/phosphorylated STAT3 axis for the treatment of non-small cell lung cancer	19
Pharmacological inhibition of FABP7 by MF 6 counteracts cerebellum dysfunction in an experimental multiple system atrophy mouse model	19
Novel insights into NOD-like receptors in renal diseases	19

Multifaceted roles of UFMylation in health and disease	19
GPR41 deficiency aggravates type 1 diabetes in streptozotocin-treated mice by promoting dendritic cell maturation	19
Cyclic GMP-AMP synthase recognizes the physical features of DNA	19
Hypocrellin A from an ethnic medicinal fungus protects against NLRP3-driven gout in mice by suppressing inflammasome activation	19
Targeted VEGFA therapy in regulating early acute kidney injury and late fibrosis	18
Chalcone derivatives ameliorate lipopolysaccharide-induced acute lung injury and inflammation by targeting MD2	18
Luteolin ameliorates chronic stress-induced depressive-like behaviors in mice by promoting the Arginase-1+ microglial phenotype via a PPARγ-dependent mechanism	18
Exploring the constitutive activation mechanism of the class A orphan GPR20	18
A novel and effective approach to generate germline-like monoclonal antibodies by integration of phage and mammalian cell display platforms	18
AXL antibody and AXL-ADC mediate antitumor efficacy via targeting AXL in tumor-intrinsic epithelial-mesenchymal transition and tumor-associated M2-like macrophage	18
Prenatal dexamethasone exposure impairs rat blood-testis barrier function and sperm quality in adult offspring via GR/KDM1B/FSTL3/TGFβ signaling	18
DZ2002 alleviates corneal angiogenesis and inflammation in rodent models of dry eye disease via regulating STAT3-PI3K-Akt-NF-κB pathway	18
Cardiac-specific deletion of BRG1 ameliorates ventricular arrhythmia in mice with myocardial infarction	18
Gentiopicroside ameliorates psoriasis-like skin lesions in mice via regulating the Keap1-Nrf2 pathway and inhibiting keratinocyte activation	18
Urolithin A ameliorates obesity-induced metabolic cardiomyopathy in mice via mitophagy activation	18
Tetrandrine alleviates silicosis by inhibiting canonical and non-canonical NLRP3 inflammasome activation in lung macrophages	18
Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis	18
Adiponectin receptor agonist AdipoRon modulates human and mouse platelet function	17
Inhibition of HIF-prolyl hydroxylase promotes renal tubule regeneration via the reprogramming of renal proximal tubular cells	17
Correction: A novel annexin dimer targets microglial phagocytosis of astrocytes to protect the brain-blood barrier after cerebral ischemia	17
Dysregulation of iron homeostasis and methamphetamine reward behaviors in Clk1-deficient mice	17
GLP-1 mimetics as a potential therapy for nonalcoholic steatohepatitis	17
Characterization of LTr1 derived from cruciferous vegetables as a novel anti-glioma agent via inhibiting TrkA/PI3K/AKT pathway	17
Activation of D2-like dopamine receptors improves the neuronal network and cognitive function of PPT1KI mice	17
NADPHnet: a novel strategy to predict compounds for regulation of NADPH metabolism via network-based methods	17
Modified citrus pectin inhibits breast cancer development in mice by targeting tumor-associated macrophage survival and polarization in hypoxic microenvironment	17
PHLDA1 contributes to hypoxic ischemic brain injury in neonatal rats via inhibiting FUNDC1-mediated mitophagy	17
Neuropeptide-mediated activation of astrocytes improves stress resilience in mice by modulating cortical neural synapses	17
Circular RNA hsa_circ_0000288 protects against epilepsy in mice by binding to and stabilizing caprin1 protein	17
The PIWI-interacting RNA CRAPIR alleviates myocardial ischemia‒reperfusion injury by reducing p53-mediated apoptosis via binding to SRSF1	17
Dl-3-n-butylphthalide promotes angiogenesis in ischemic stroke mice through upregulating autocrine and paracrine sonic hedgehog	17
Inhibition of CD36 ameliorates mouse spinal cord injury by accelerating microglial lipophagy	16
Prenatal dexamethasone exposure programs the decreased testosterone synthesis in offspring rats by low level of endogenous glucocorticoids	16
Notoginsenoside R1 protects against myocardial ischemia/reperfusion injury in mice via suppressing TAK1-JNK/p38 signaling	16
Discovery of FO-4-15, a novel 1,2,4-oxadiazole derivative, ameliorates cognitive impairments in 3×Tg mice by activating the mGluR1/CaMKIIα pathway	16
SARS-CoV-2 receptor binding domain radio-probe: a non-invasive approach for angiotensin-converting enzyme 2 mapping in mice	16
Pyk2 inhibition attenuates hypoxic-ischemic brain injury in neonatal mice	16
Signaling profiles in HEK 293T cells co-expressing GLP-1 and GIP receptors	16
Deep learning enables the discovery of a novel cuproptosis-inducing molecule for the inhibition of hepatocellular carcinoma	16
Updates on novel pharmacotherapeutics for the treatment of nonalcoholic steatohepatitis	16
ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway	16
Brigatinib, a newly discovered AXL inhibitor, suppresses AXL-mediated acquired resistance to osimertinib in EGFR-mutated non-small cell lung cancer	16
Thermoregulatory pathway underlying the pyrogenic effects of prostaglandin E2 in the lateral parabrachial nucleus of male rats	15
A novel selective ERK1/2 inhibitor, Laxiflorin B, targets EGFR mutation subtypes in non-small-cell lung cancer	15
Colchicine reduces neointima formation and VSMC phenotype transition by modulating SRF-MYOCD activation and autophagy	15
Heat shock protein family A member 8 serving as a co-activator of transcriptional factor ETV4 up-regulates PHLDA2 to promote the growth of liver cancer	15
Deubiquitinating enzyme USP11 promotes renal tubular cell senescence and fibrosis via inhibiting the ubiquitin degradation of TGF-β receptor II	15
124I-labeled anti-CD147 antibody for noninvasive detection of CD147-positive pan-cancers: construction and preclinical studies	15
Aberrant neuronal excitation promotes neuroinflammation in the primary motor cortex of ischemic stroke mice	15
Roflupram protects against rotenone-induced neurotoxicity and facilitates α-synuclein degradation in Parkinson’s disease models	15
Inhibiting the transcription and replication of Ebola viruses by disrupting the nucleoprotein and VP30 protein interaction with small molecules	15
Serum granulosa cell-derived TNF-α promotes inflammation and apoptosis of renal tubular cells and PCOS-related kidney injury through NF-κB signaling	15
An efficient deep learning-based strategy to screen inhibitors for GluN1/GluN3A receptor	15
Role of thrombospondin-1 in high-salt–induced mesenteric artery endothelial impairment in rats	15
MMP-9 inhibitor SB-3CT improves neurological outcomes in ischemic stroke mice by modulation of astrocytic lipid metabolism	15
USP11 promotes renal tubular cell pyroptosis and fibrosis in UUO mice via inhibiting KLF4 ubiquitin degradation	15
Differential modulation of subthalamic projection neurons by short-term and long-term electrical stimulation in physiological and parkinsonian conditions	15
A novel small-molecule PCSK9 inhibitor E28362 ameliorates hyperlipidemia and atherosclerosis	14
Tetramethylpyrazine prevents liver fibrotic injury in mice by targeting hepatocyte-derived and mitochondrial DNA-enriched extracellular vesicles	14
Author Correction: α-Galactosylceramide and its analog OCH differentially affect the pathogenesis of ISO-induced cardiac injury in mice	14
Mass spectrometry imaging: new eyes on natural products for drug research and development	14
The aminosteroid U73122 promotes oligodendrocytes generation and myelin formation	14
Ivacaftor, a CFTR potentiator, synergizes with osimertinib against acquired resistance to osimertinib in NSCLC by regulating CFTR-PTEN-AKT axis	14
TGFβR-1/ALK5 inhibitor RepSox induces enteric glia-to-neuron transition and influences gastrointestinal mobility in adult mice	14
Chemokine CCL2 promotes cardiac regeneration and repair in myocardial infarction mice via activation of the JNK/STAT3 axis	14
Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson’s disease treatment	14
Luteolin alleviates cognitive impairment in Alzheimer’s disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation	14
YY1/HIF-1α/mROS positive-feedback loop exacerbates glomerular mesangial cell proliferation in mouse early diabetic kidney disease	14
Liver receptor homolog-1: structures, related diseases, and drug discovery	14
6-Methyl flavone inhibits Nogo-B expression and improves high fructose diet-induced liver injury in mice	14
O-GlcNAcylation mediates H2O2-induced apoptosis through regulation of STAT3 and FOXO1	14
Pentapeptide PYRAE triggers ER stress-mediated apoptosis of breast cancer cells in mice by targeting RHBDF1-BiP interaction	14
Novel Caspase-1 inhibitor CZL80 improves neurological function in mice after progressive ischemic stroke within a long therapeutic time-window	14
Dihydroartemisinin suppresses renal fibrosis in mice by inhibiting DNA-methyltransferase 1 and increasing Klotho	14
Indoxyl sulphate-TNFα axis mediates uremic encephalopathy in rodent acute kidney injury	14
Activation of TRPV1 receptor facilitates myelin repair following demyelination via the regulation of microglial function	14
A structure-based virtual screening identifies a novel MDM2 antagonist in the activation of the p53 signaling and inhibition of tumor growth	14
α-MSH-catabolic enzyme prolylcarboxypeptidase in nucleus accumbens shell ameliorates stress susceptibility in mice through regulating synaptic plasticity	14
Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3	14