Acta Pharmacologica Sinica

Article	Citations
Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19	1530
Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients	303
Small molecule inhibitors targeting the PD-1/PD-L1 signaling pathway	193
Hypoxia, HIF-1α, and COVID-19: from pathogenic factors to potential therapeutic targets	149
Natural products: potential treatments for cisplatin-induced nephrotoxicity	142
Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma	135
Drp1-dependent mitochondrial fission in cardiovascular disease	128
Growth factors-based therapeutic strategies and their underlying signaling mechanisms for peripheral nerve regeneration	104
Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies	96
Caspase-11/4 and gasdermin D-mediated pyroptosis contributes to podocyte injury in mouse diabetic nephropathy	95
Engineering nanomedicines through boosting immunogenic cell death for improved cancer immunotherapy	91
Matrine attenuates pathological cardiac fibrosis via RPS5/p38 in mice	85
Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation	82
ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma	81
Baicalin prevents LPS-induced activation of TLR4/NF-κB p65 pathway and inflammation in mice via inhibiting the expression of CD14	66
Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases	62
Advanced biomaterials for cancer immunotherapy	60
Identification of SARS-CoV-2 entry inhibitors among already approved drugs	59
Structure genomics of SARS-CoV-2 and its Omicron variant: drug design templates for COVID-19	58
ATF3 contributes to brucine-triggered glioma cell ferroptosis via promotion of hydrogen peroxide and iron	58
Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia	58
NRF2-GPX4/SOD2 axis imparts resistance to EGFR-tyrosine kinase inhibitors in non-small-cell lung cancer cells	56
Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer’s disease via inhibition of ACSL4-dependent ferroptosis	56
Ex vivo pulsed dendritic cell vaccination against cancer	56
Nrf2 activation ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain	55

Deletion of TLR4 attenuates lipopolysaccharide-induced acute liver injury by inhibiting inflammation and apoptosis	54
Luteolin alleviates cognitive impairment in Alzheimer’s disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation	53
Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabetic kidney disease	53
Baicalein attenuates cardiac hypertrophy in mice via suppressing oxidative stress and activating autophagy in cardiomyocytes	52
DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress	51
Mitochondrial Ca2+ regulation in the etiology of heart failure: physiological and pathophysiological implications	51
New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer’s disease	50
Mutations in key driver genes of pancreatic cancer: molecularly targeted therapies and other clinical implications	50
Metformin and cancer immunity	50
Gut microbiota dysbiosis-induced activation of the intrarenal renin–angiotensin system is involved in kidney injuries in rat diabetic nephropathy	49
Baicalein ameliorates ulcerative colitis by improving intestinal epithelial barrier via AhR/IL-22 pathway in ILC3s	48
The glycolytic process in endothelial cells and its implications	47
Recombinant human ACE2: potential therapeutics of SARS-CoV-2 infection and its complication	47
Sirt1 inhibits renal tubular cell epithelial–mesenchymal transition through YY1 deacetylation in diabetic nephropathy	46
PEITC triggers multiple forms of cell death by GSH-iron-ROS regulation in K7M2 murine osteosarcoma cells	45
NOD-like receptors in autoimmune diseases	45
Harnessing nanomedicine to overcome the immunosuppressive tumor microenvironment	45
N-myristoylation: from cell biology to translational medicine	44
Zinc as a countermeasure for cadmium toxicity	43
Icariside II attenuates cerebral ischemia/reperfusion-induced blood–brain barrier dysfunction in rats via regulating the balance of MMP9/TIMP1	42
A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors	42
Potential application of endocannabinoid system agents in neuropsychiatric and neurodegenerative diseases—focusing on FAAH/MAGL inhibitors	42
Salvianolic acid A prevented cerebrovascular endothelial injury caused by acute ischemic stroke through inhibiting the Src signaling pathway	41
Atomic force microscopy for revealing micro/nanoscale mechanics in tumor metastasis: from single cells to microenvironmental cues	41
Therapeutic potential of colchicine in cardiovascular medicine: a pharmacological review	41
Widespread myocardial dysfunction in COVID-19 patients detected by myocardial strain imaging using 2-D speckle-tracking echocardiography	40
Rg1 improves LPS-induced Parkinsonian symptoms in mice via inhibition of NF-κB signaling and modulation of M1/M2 polarization	39
Angiogenin and tRNA fragments in Parkinson’s disease and neurodegeneration	38
Tu-San-Qi (Gynura japonica): the culprit behind pyrrolizidine alkaloid-induced liver injury in China	38
Nanomedicine-based immunotherapy for central nervous system disorders	37
Pharmacokinetics and tissue distribution of remdesivir and its metabolites nucleotide monophosphate, nucleotide triphosphate, and nucleoside in mice	37
Metformin promotes microglial cells to facilitate myelin debris clearance and accelerate nerve repairment after spinal cord injury	37
Targeting HMGB1 for the treatment of sepsis and sepsis-induced organ injury	37
Pyroptosis and pyroptosis-inducing cancer drugs	37
Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog against SARS-CoV-2, in Chinese healthy subjects	36
Overview of therapeutic drug research for COVID-19 in China	36
Research progress on the protective effects of licorice-derived 18β-glycyrrhetinic acid against liver injury	36
Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein	36
Blueberry-derived exosomes-like nanoparticles ameliorate nonalcoholic fatty liver disease by attenuating mitochondrial oxidative stress	36
Cardamonin protects against lipopolysaccharide-induced myocardial contractile dysfunction in mice through Nrf2-regulated mechanism	35
Ferroptosis in viral infection: the unexplored possibility	35
Ginsenoside Rb1 alleviates diabetic kidney podocyte injury by inhibiting aldose reductase activity	35
Melatonin promotes cardiomyocyte proliferation and heart repair in mice with myocardial infarction via miR-143-3p/Yap/Ctnnd1 signaling pathway	34
Tetrandrine alleviates silicosis by inhibiting canonical and non-canonical NLRP3 inflammasome activation in lung macrophages	34
MDL-800, an allosteric activator of SIRT6, suppresses proliferation and enhances EGFR-TKIs therapy in non-small cell lung cancer	34
Celastrol induces lipophagy via the LXRα/ABCA1 pathway in clear cell renal cell carcinoma	34
Involvement of the secreted protein Metrnl in human diseases	34
Diterbutyl phthalate attenuates osteoarthritis in ACLT mice via suppressing ERK/c-fos/NFATc1 pathway, and subsequently inhibiting subchondral osteoclast fusion	33
β-sitosterol ameliorates influenza A virus-induced proinflammatory response and acute lung injury in mice by disrupting the cross-talk between RIG-I and IFN/STAT signaling	33
AlphaFold2 versus experimental structures: evaluation on G protein-coupled receptors	33

Autophagy-dependent removal of α-synuclein: a novel mechanism of GM1 ganglioside neuroprotection against Parkinson’s disease	33
Pyrroloquinoline quinone promotes mitochondrial biogenesis in rotenone-induced Parkinson’s disease model via AMPK activation	33
Current advances in the use of exosomes, liposomes, and bioengineered hybrid nanovesicles in cancer detection and therapy	33
Synergistic antitumor activity of sorafenib and artesunate in hepatocellular carcinoma cells	32
Disulfiram-loaded lactoferrin nanoparticles for treating inflammatory diseases	31
The hepatotoxicity of Polygonum multiflorum: The emerging role of the immune-mediated liver injury	31
Cancer nanomedicine meets immunotherapy: opportunities and challenges	31
Regulatory T cells in ischemic stroke	31
KLF4 initiates sustained YAP activation to promote renal fibrosis in mice after ischemia-reperfusion kidney injury	31
Catalpol improves impaired neurovascular unit in ischemic stroke rats via enhancing VEGF-PI3K/AKT and VEGF-MEK1/2/ERK1/2 signaling	31
Emerging roles of class I PI3K inhibitors in modulating tumor microenvironment and immunity	31
Nanomedicines based on nanoscale metal-organic frameworks for cancer immunotherapy	31
Bile acid and receptors: biology and drug discovery for nonalcoholic fatty liver disease	31
Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3	31
Short-chain fatty acids exert opposite effects on the expression and function of p-glycoprotein and breast cancer resistance protein in rat intestine	30
Chitosan oligosaccharide modified liposomes enhance lung cancer delivery of paclitaxel	30
Gasdermin E-derived caspase-3 inhibitors effectively protect mice from acute hepatic failure	30
TGFβ2-mediated epithelial–mesenchymal transition and NF-κB pathway activation contribute to osimertinib resistance	30
Benzimidazoles induce concurrent apoptosis and pyroptosis of human glioblastoma cells via arresting cell cycle	30
Gastrodin protects H9c2 cardiomyocytes against oxidative injury by ameliorating imbalanced mitochondrial dynamics and mitochondrial dysfunction	29
Polydatin attenuates renal fibrosis in diabetic mice through regulating the Cx32-Nox4 signaling pathway	29
Application of targeted therapy strategies with nanomedicine delivery for atherosclerosis	29
Berberine alleviates visceral hypersensitivity in rats by altering gut microbiome and suppressing spinal microglial activation	29
Bispecific antibody simultaneously targeting PD1 and HER2 inhibits tumor growth via direct tumor cell killing in combination with PD1/PDL1 blockade and HER2 inhibition	29
Puerarin ameliorated pressure overload-induced cardiac hypertrophy in ovariectomized rats through activation of the PPARα/PGC-1 pathway	28
Lp-PLA2 inhibition prevents Ang II-induced cardiac inflammation and fibrosis by blocking macrophage NLRP3 inflammasome activation	28
Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated fatty liver disease in mice: potential involvement of PANoptosis	28
Nanomedicine and cancer immunotherapy	28
Pirfenidone ameliorates silica-induced lung inflammation and fibrosis in mice by inhibiting the secretion of interleukin-17A	27
Suppression of the USP10/CCND1 axis induces glioblastoma cell apoptosis	27
Intrinsic and acquired resistance to CDK4/6 inhibitors and potential overcoming strategies	27
The m6A demethylase FTO promotes the osteogenesis of mesenchymal stem cells by downregulating PPARG	27
STING inhibitor ameliorates LPS-induced ALI by preventing vascular endothelial cells-mediated immune cells chemotaxis and adhesion	27
Ursolic acid reduces hepatocellular apoptosis and alleviates alcohol-induced liver injury via irreversible inhibition of CASP3 in vivo	27
Gout-associated monosodium urate crystal-induced necrosis is independent of NLRP3 activity but can be suppressed by combined inhibitors for multiple signaling pathways	27
6-Gingerol protects against cardiac remodeling by inhibiting the p38 mitogen-activated protein kinase pathway	26
Structure, regulation, and biological functions of TIGAR and its role in diseases	26
Garciesculenxanthone B induces PINK1-Parkin-mediated mitophagy and prevents ischemia-reperfusion brain injury in mice	26
Ethyl ferulate protects against lipopolysaccharide-induced acute lung injury by activating AMPK/Nrf2 signaling pathway	26
Diosmetin has therapeutic efficacy in colitis regulating gut microbiota, inflammation, and oxidative stress via the circ-Sirt1/Sirt1 axis	26
FOXO3a protects glioma cells against temozolomide-induced DNA double strand breaks via promotion of BNIP3-mediated mitophagy	26
The artemisinin analog SM934 alleviates dry eye disease in rodent models by regulating TLR4/NF-κB/NLRP3 signaling	26
Tanshinone IIA prevents LPS-induced inflammatory responses in mice via inactivation of succinate dehydrogenase in macrophages	25
Subtype-selective mechanisms of negative allosteric modulators binding to group I metabotropic glutamate receptors	25
Sphingomyelin synthase 2 facilitates M2-like macrophage polarization and tumor progression in a mouse model of triple-negative breast cancer	25
Pretreatment with chitosan oligosaccharides attenuate experimental severe acute pancreatitis via inhibiting oxidative stress and modulating intestinal homeostasis	25
Probiotics protect against RSV infection by modulating the microbiota-alveolar-macrophage axis	25
Exploring the protective effects of schizandrol A in acute myocardial ischemia mice by comprehensive metabolomics profiling integrated with molecular mechanism studies	25
Targeting the cholinergic system in Parkinson’s disease	25
Inhibition of AXL enhances chemosensitivity of human ovarian cancer cells to cisplatin via decreasing glycolysis	24
MicroRNAs are involved in the development and progression of gastric cancer	24
Caspase-11 promotes NLRP3 inflammasome activation via the cleavage of pannexin1 in acute kidney disease	24
GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages	24
Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53	24
Lipid/PAA-coated mesoporous silica nanoparticles for dual-pH-responsive codelivery of arsenic trioxide/paclitaxel against breast cancer cells	24
Clinical characteristics and related risk factors of disease severity in 101 COVID-19 patients hospitalized in Wuhan, China	24
MicroRNA-99b-3p promotes angiotensin II-induced cardiac fibrosis in mice by targeting GSK-3β	24
Dapagliflozin attenuates pressure overload-induced myocardial remodeling in mice via activating SIRT1 and inhibiting endoplasmic reticulum stress	23
Nanoengineered targeting strategy for cancer immunotherapy	23
Fisetin alleviates sepsis-induced multiple organ dysfunction in mice via inhibiting p38 MAPK/MK2 signaling	23
Cinnamaldehyde induces autophagy-mediated cell death through ER stress and epigenetic modification in gastric cancer cells	23
Surface loading of nanoparticles on engineered or natural erythrocytes for prolonged circulation time: strategies and applications	23
BMSC-derived exosomes ameliorate sulfur mustard-induced acute lung injury by regulating the GPRC5A–YAP axis	23
Ruscogenin attenuates particulate matter-induced acute lung injury in mice via protecting pulmonary endothelial barrier and inhibiting TLR4 signaling pathway	23
The novel cereblon modulator CC-885 inhibits mitophagy via selective degradation of BNIP3L	23
Triptolide suppresses the growth and metastasis of non-small cell lung cancer by inhibiting β-catenin-mediated epithelial–mesenchymal transition	23
Avasimibe exerts anticancer effects on human glioblastoma cells via inducing cell apoptosis and cell cycle arrest	23
Intrarenal 1-methoxypyrene, an aryl hydrocarbon receptor agonist, mediates progressive tubulointerstitial fibrosis in mice	23
Updates on novel pharmacotherapeutics for the treatment of nonalcoholic steatohepatitis	22
DL0410 ameliorates cognitive disorder in SAMP8 mice by promoting mitochondrial dynamics and the NMDAR-CREB-BDNF pathway	22
Novel CDK9 inhibitor oroxylin A promotes wild-type P53 stability and prevents hepatocellular carcinoma progression by disrupting both MDM2 and SIRT1 signaling	22
Ginsenoside Rb1 alleviates colitis in mice via activation of endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 signaling pathway	22
Direct cardio-protection of Dapagliflozin against obesity-related cardiomyopathy via NHE1/MAPK signaling	22
TRIM25 activates AKT/mTOR by inhibiting PTEN via K63-linked polyubiquitination in non-small cell lung cancer	22
Multi-compound and drug-combination pharmacokinetic research on Chinese herbal medicines	22
Reduced nicotinamide adenine dinucleotide phosphate in redox balance and diseases: a friend or foe?	22
Interleukin-17 upregulation participates in the pathogenesis of heart failure in mice via NF-κB-dependent suppression of SERCA2a and Cav1.2 expression	22
Activation of GPR120 in podocytes ameliorates kidney fibrosis and inflammation in diabetic nephropathy	21
Bmal1 inhibits phenotypic transformation of hepatic stellate cells in liver fibrosis via IDH1/α-KG-mediated glycolysis	21
Metrnl deficiency decreases blood HDL cholesterol and increases blood triglyceride	21

Pristimerin protects against inflammation and metabolic disorder in mice through inhibition of NLRP3 inflammasome activation	21
Gut microbiota in pancreatic diseases: possible new therapeutic strategies	21
A simple, quick, and efficient CRISPR/Cas9 genome editing method for human induced pluripotent stem cells	21
Targeted inhibition of calpain in mitochondria alleviates oxidative stress-induced myocardial injury	21
Artemisinin improves neurocognitive deficits associated with sepsis by activating the AMPK axis in microglia	21
Methylene blue ameliorates brain edema in rats with experimental ischemic stroke via inhibiting aquaporin 4 expression	21
Aloe-emodin exerts cholesterol-lowering effects by inhibiting proprotein convertase subtilisin/kexin type 9 in hyperlipidemic rats	21
Ginsenoside Rg1 exerts neuroprotective effects in 3-nitropronpionic acid-induced mouse model of Huntington’s disease via suppressing MAPKs and NF-κB pathways in the striatum	20
Mesenchymal stem cells in fibrotic diseases—the two sides of the same coin	20
Anti-PD-L1 mediating tumor-targeted codelivery of liposomal irinotecan/JQ1 for chemo-immunotherapy	20
Zonisamide, an antiepileptic drug, alleviates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress	20
Pharmacokinetics-based identification of pseudoaldosterogenic compounds originating from Glycyrrhiza uralensis roots (Gancao) after dosing LianhuaQingwen capsule	20
Trilobatin rescues cognitive impairment of Alzheimer’s disease by targeting HMGB1 through mediating SIRT3/SOD2 signaling pathway	20
Dipeptidyl peptidase 4 inhibitor sitagliptin protected against dextran sulfate sodium-induced experimental colitis by potentiating the action of GLP-2	20
Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52	20
Betulinic acid hydroxamate prevents colonic inflammation and fibrosis in murine models of inflammatory bowel disease	20
Caffeine promotes angiogenesis through modulating endothelial mitochondrial dynamics	20
Anti-inflammatory signaling through G protein-coupled receptors	20
Bergenin, a PPARγ agonist, inhibits Th17 differentiation and subsequent neutrophilic asthma by preventing GLS1-dependent glutaminolysis	19
GJA1-20k attenuates Ang II-induced pathological cardiac hypertrophy by regulating gap junction formation and mitochondrial function	19
Methylene blue prevents osteoarthritis progression and relieves pain in rats via upregulation of Nrf2/PRDX1	19
Mzb1 protects against myocardial infarction injury in mice via modulating mitochondrial function and alleviating inflammation	19
WNK-SPAK/OSR1-NCC kinase signaling pathway as a novel target for the treatment of salt-sensitive hypertension	19
Post-translational modification of KRAS: potential targets for cancer therapy	19
Sorafenib triggers ferroptosis via inhibition of HBXIP/SCD axis in hepatocellular carcinoma	19
Psychosis in Parkinson’s disease and parkinsonism in antipsychotic-naive schizophrenia spectrum psychosis: clinical, nosological and pathobiological challenges	19
ZEB1 serves an oncogenic role in the tumourigenesis of HCC by promoting cell proliferation, migration, and inhibiting apoptosis via Wnt/β-catenin signaling pathway	18
Druggability of lipid metabolism modulation against renal fibrosis	18
Pantoprazole ameliorates liver fibrosis and suppresses hepatic stellate cell activation in bile duct ligation rats by promoting YAP degradation	18
Reversal of the immunosuppressive tumor microenvironment by nanoparticle-based activation of immune-associated cells	18
PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours	18
Neuronal chemokine-like-factor 1 (CKLF1) up-regulation promotes M1 polarization of microglia in rat brain after stroke	18
Nanomedicine-mediated alteration of the pharmacokinetic profile of small molecule cancer immunotherapeutics	18
Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives	18
RIP1 promotes proliferation through G2/M checkpoint progression and mediates cisplatin-induced apoptosis and necroptosis in human ovarian cancer cells	18
Sodium propionate exerts anticancer effect in mice bearing breast cancer cell xenograft by regulating JAK2/STAT3/ROS/p38 MAPK signaling	18
Feasibility study of 68Ga-labeled CAR T cells for in vivo tracking using micro-positron emission tomography imaging	18
Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer	17
Integrative phosphatidylcholine metabolism through phospholipase A2 in rats with chronic kidney disease	17
DCZ5248, a novel dual inhibitor of Hsp90 and autophagy, exerts antitumor activity against colon cancer	17
Cepharanthine sensitizes human triple negative breast cancer cells to chemotherapeutic agent epirubicin via inducing cofilin oxidation-mediated mitochondrial fission and apoptosis	17
Hepatocyte-derived VEGFA accelerates the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma via activating hepatic stellate cells	17
Roxithromycin attenuates bleomycin-induced pulmonary fibrosis by targeting senescent cells	17
Asiatic acid alleviates ischemic myocardial injury in mice by modulating mitophagy- and glycophagy-based energy metabolism	17
FXR: structures, biology, and drug development for NASH and fibrosis diseases	17
DrugRep: an automatic virtual screening server for drug repurposing	17
Pramipexole inhibits astrocytic NLRP3 inflammasome activation via Drd3-dependent autophagy in a mouse model of Parkinson’s disease	17
Osimertinib successfully combats EGFR-negative glioblastoma cells by inhibiting the MAPK pathway	17
TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2	17
A brief guide to good practices in pharmacological experiments: Western blotting	17
Inhibition of miR-135a-5p attenuates vascular smooth muscle cell proliferation and vascular remodeling in hypertensive rats	17
Kanglexin delays heart aging by promoting mitophagy	17
A novel Diels–Alder adduct of mulberry leaves exerts anticancer effect through autophagy-mediated cell death	17
Chromatin accessibility analysis reveals that TFAP2A promotes angiogenesis in acquired resistance to anlotinib in lung cancer cells	16
Blockage of sphingosine-1-phosphate receptor 2 attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice	16
Melittin ameliorates inflammation in mouse acute liver failure via inhibition of PKM2-mediated Warburg effect	16
L-Carnitine protects against tacrolimus-induced renal injury by attenuating programmed cell death via PI3K/AKT/PTEN signaling	16
G3BP1 promotes human breast cancer cell proliferation through coordinating with GSK-3β and stabilizing β-catenin	16
The C terminus of DJ-1 determines its homodimerization, MGO detoxification activity and suppression of ferroptosis	16
Fatty acid-binding protein 7 triggers α-synuclein oligomerization in glial cells and oligodendrocytes associated with oxidative stress	16
Ginsenoside Rg1 in neurological diseases: From bench to bedside	16
MicroRNA-214 contributes to Ang II-induced cardiac hypertrophy by targeting SIRT3 to provoke mitochondrial malfunction	16
A GLP-1 analog lowers ER stress and enhances protein folding to ameliorate homocysteine-induced endothelial dysfunction	16
Wu-5, a novel USP10 inhibitor, enhances crenolanib-induced FLT3-ITD-positive AML cell death via inhibiting FLT3 and AMPK pathways	16
Extracellular vesicles in vascular remodeling	16
Activating α7nAChR ameliorates abdominal aortic aneurysm through inhibiting pyroptosis mediated by NLRP3 inflammasome	16
Ganoderic acid alleviates chemotherapy-induced fatigue in mice bearing colon tumor	16
Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis	16
1,2,4-Trimethoxybenzene selectively inhibits NLRP3 inflammasome activation and attenuates experimental autoimmune encephalomyelitis	16
Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy	16
10,11-dehydrocurvularin exerts antitumor effect against human breast cancer by suppressing STAT3 activation	16
Engineered nanomedicines block the PD-1/PD-L1 axis for potentiated cancer immunotherapy	16
Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates	15
CDER167, a dual inhibitor of URAT1 and GLUT9, is a novel and potent uricosuric candidate for the treatment of hyperuricemia	15
Inhibition of drug-metabolizing enzymes by Jingyin granules: implications of herb–drug interactions in antiviral therapy	15
Inhibition of histamine receptor H3 suppresses the growth and metastasis of human non-small cell lung cancer cells via inhibiting PI3K/Akt/mTOR and MEK/ERK signaling pathways and blocking EMT	15
The impact of cannabinoid type 2 receptors (CB2Rs) in neuroprotection against neurological disorders	15
Sulforaphane activates anti-inflammatory microglia, modulating stress resilience associated with BDNF transcription	15
Pseudoginsenoside-F11 attenuates cognitive dysfunction and tau phosphorylation in sporadic Alzheimer’s disease rat model	15
Berberine inhibits colorectal tumor growth by suppressing SHH secretion	15
Phase separation as a therapeutic target in tight junction-associated human diseases	15
Rictor/mTORC2 involves mitochondrial function in ES cells derived cardiomyocytes via mitochondrial Connexin 43	15
Diabetes downregulates peptide transporter 1 in the rat jejunum: possible involvement of cholate-induced FXR activation	15
Development of a nanobody-based immunoassay for the sensitive detection of fibrinogen-like protein 1	15
Lupeol protects against cardiac hypertrophy via TLR4-PI3K-Akt-NF-κB pathways	15
Exogenous glutathione exerts a therapeutic effect in ischemic stroke rats by interacting with intrastriatal dopamine	15
Noncoding RNAs in doxorubicin-induced cardiotoxicity and their potential as biomarkers and therapeutic targets	15
Modulating mitochondrial dynamics attenuates cardiac ischemia-reperfusion injury in prediabetic rats	15
Tetramethylpyrazine prevents liver fibrotic injury in mice by targeting hepatocyte-derived and mitochondrial DNA-enriched extracellular vesicles	14
Paris saponin VII, a Hippo pathway activator, induces autophagy and exhibits therapeutic potential against human breast cancer cells	14
NADPH is superior to NADH or edaravone in ameliorating metabolic disturbance and brain injury in ischemic stroke	14
β-Arrestin2 deficiency attenuates oxidative stress in mouse hepatic fibrosis through modulation of NOX4	14
3,4-dihydroxytoluene, a metabolite of rutin, suppresses the progression of nonalcoholic fatty liver disease in mice by inhibiting p300 histone acetyltransferase activity	14
Drinking water temperature affects cognitive function and progression of Alzheimer’s disease in a mouse model	14
Drug development in targeting ion channels for brain edema	14