Acta Pharmacologica Sinica

Article	Citations
Author Correction: Discovery of toxoflavin, a potent IRE1α inhibitor acting through structure-dependent oxidative inhibition	310
Satellite cell-derived exosome-mediated delivery of microRNA-23a/27a/26a cluster ameliorates the renal tubulointerstitial fibrosis in mouse diabetic nephropathy	220
Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates	164
Identification of Licoflavone C as a cap-dependent endonuclease inhibitor against severe fever with thrombocytopenia syndrome virus	141
Translin deletion impairs cocaine-induced locomotor sensitization and RGS8 expression in the nucleus accumbens	129
Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition	119
Magnolin overcomes EGFR TKI resistance in NSCLC by modulation of NDRG1-NRG2-HECW1 pathway	116
Compound 38, a novel potent and selective antagonist of adenosine A2A receptor, enhances arousal in mice	108
S670, an amide derivative of 3-O-acetyl-11-keto-β-boswellic acid, induces ferroptosis in human glioblastoma cells by generating ROS and inhibiting STX17-mediated fusion of autophagosome and lysosome	101
Reducing lipid peroxidation attenuates stress-induced susceptibility to herpes simplex virus type 1	94
Cystathionine γ-lyase-derived H2S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase	92
Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren’s syndrome in mice by promoting TEC kinase degradation	92
Celastrol suppresses the growth of vestibular schwannoma in mice by promoting the degradation of β-catenin	89
Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson’s disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle	86
MC1R and melanin-based molecular probes for theranostic of melanoma and beyond	84
The hybrid oncolytic peptide NTP-385 potently inhibits adherent cancer cells by targeting the nucleus	79
GRK2-mediated phosphorylation and de-succinylation of PKM2 reduce macrophage glycolysis in rheumatoid arthritis	75
Single-dose methamphetamine administration impairs ORM retrieval in mice via excessive DA-mediated inhibition of PrLGlu activity	75
Channelopathy of small- and intermediate-conductance Ca2+-activated K+ channels	72
Pyroptosis and pyroptosis-inducing cancer drugs	70
Extracellular vesicles in vascular remodeling	68
Targeted degradation of membrane and extracellular proteins with LYTACs	67
tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis	67
Otilonium bromide ameliorates pulmonary fibrosis in mice through activating phosphatase PPM1A	67
Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-κB p65-activated SLC7A11 transcription	63

Activating Wnt/β-catenin signaling by autophagic degradation of APC contributes to the osteoblast differentiation effect of soy isoflavone on osteoporotic mesenchymal stem cells	63
Correction to: EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells	61
Author Correction: ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway	61
Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation	61
Resibufogenin ameliorates cerebral ischemia-reperfusion injury by modulating microglial redox homeostasis via Keap1-Nrf2-TFR1/ARE axis	57
143D, a novel selective KRASG12C inhibitor exhibits potent antitumor activity in preclinical models	56
Insomnia-related rodent models in drug discovery	56
Retraction Note: Physcion inhibits the metastatic potential of human colorectal cancer SW620 cells in vitro by suppressing the transcription factor SOX2	55
Gastrodin promotes CNS myelinogenesis and alleviates demyelinating injury by activating the PI3K/AKT/mTOR signaling	54
Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer	54
Dual-responsive nanoparticles loading bevacizumab and gefitinib for molecular targeted therapy against non-small cell lung cancer	54
Exploring the distinct activation mechanisms of neuromedin B receptor through multiple replica molecular dynamics simulations and Markov state modeling	54
FX5, a non-steroidal glucocorticoid receptor antagonist, ameliorates diabetic cognitive impairment in mice	53
Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376	53
Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway	50
DNMT inhibition epigenetically restores the cGAS-STING pathway and activates RIG-I/MDA5-MAVS to enhance antitumor immunity	48
p52-ZER6: a determinant of tumor cell sensitivity to MDM2-p53 binding inhibitors	47
Dendritic cell-liposome conjugates reverse immunosuppressive tumor microenvironment for inhibiting colitis-associated colorectal cancer	47
LN-439A, a novel BAP1 inhibitor, suppresses the growth of basal-like breast cancer by degrading KLF5	46
Transcriptional regulation and small compound targeting of ACE2 in lung epithelial cells	45
Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial calcium-mediated renal tubular cell senescence	45
Chronic infusion of ELABELA alleviates vascular remodeling in spontaneously hypertensive rats via anti-inflammatory, anti-oxidative and anti-proliferative effects	43
Thoracic perivascular adipose tissue inhibits VSMC apoptosis and aortic aneurysm formation in mice via the secretome of browning adipocytes	43
Antagonism of histamine H3 receptor promotes angiogenesis following focal cerebral ischemia	43
TRADD-mediated pyroptosis contributes to diabetic cardiomyopathy	42
Liver X receptor inverse agonist SR9243 attenuates rheumatoid arthritis via modulating glycolytic metabolism of macrophages	42
Transport mechanism and drug discovery of human monocarboxylate transporter 1	42
Author Correction: Anti-diabetic drug canagliflozin hinders skeletal muscle regeneration in mice	41
Methionine-choline deficient diet deteriorates DSS-induced murine colitis through disturbance of gut microbes and infiltration of macrophages	41
Correction: Chemokine CCL2 promotes cardiac regeneration and repair in myocardial infarction mice via activation of the JNK/STAT3 axis	41
Krüppel-like factor 15 ameliorates alcohol-induced liver injury in mice via regulation of the PFKFB3/AKT axis	41
Contrastive learning-based drug screening model for GluN1/GluN3A inhibitors	40
A high-throughput screening campaign against PFKFB3 identified potential inhibitors with novel scaffolds	40
Modest improvement of metabolic and behavioral deficits with long-term ambroxol treatment in a Pink1−/−SNCAA53T double mutant mouse model of Parkinson’s disease	40
The diverse role of the raphe 5-HTergic systems in epilepsy	39
Porcupine inhibitor CGX1321 alleviates heart failure with preserved ejection fraction in mice by blocking WNT signaling	39
14-3-3ζ inhibits maladaptive repair in renal tubules by regulating YAP and reduces renal interstitial fibrosis	39
SAAINT-DB: a comprehensive structural antibody database for antibody modeling and design	39
Melatonin ameliorates bleomycin-induced pulmonary fibrosis via activating NRF2 and inhibiting galectin-3 expression	39
Advances in cannabinoid receptors pharmacology: from receptor structural insights to ligand discovery	38
Mitofusin-2 mediates cannabidiol-induced neuroprotection against cerebral ischemia in rats	38
Regulation of toll-like receptor (TLR) signaling pathways in atherosclerosis: from mechanisms to targeted therapeutics	38
Preclinical characterization of [18F]D2-LW223: an improved metabolically stable PET tracer for imaging the translocator protein 18 kDa (TSPO) in neuroinflammatory rodent models and non-human primates	37
Selumetinib promotes coronary collateral circulation by inducing M2-like macrophage polarization following myocardial infarction	37
Chemistry and bioactivity of secondary metabolites from South China Sea marine fauna and flora: recent research advances and perspective	37
RIPK1 inhibition contributes to lysosomal membrane stabilization in ischemic astrocytes via a lysosomal Hsp70.1B-dependent mechanism	37
JOSD2 alleviates acute kidney injury through deubiquitinating SIRT7 and negativity regulating SIRT7-NF-κB inflammatory pathway in renal tubular epithelial cells	36
NASH: regulatory considerations for clinical drug development and U.S. FDA approval	36
Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol	36
Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy	36

SGLT2 inhibitor empagliflozin promotes revascularization in diabetic mouse hindlimb ischemia by inhibiting ferroptosis	36
Fangchinoline-mediated autophagy inhibition amplifies antigen presentation and PD-1 blockade efficacy in lung cancer	36
Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated fatty liver disease in mice: potential involvement of PANoptosis	35
AlphaFold3 versus experimental structures: assessment of the accuracy in ligand-bound G protein-coupled receptors	35
Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells	35
Celastrol attenuates hepatitis C virus translation and inflammatory response in mice by suppressing heat shock protein 90β	35
Phenethyl isothiocyanate inhibits metastasis potential of non-small cell lung cancer cells through FTO mediated TLE1 m6A modification	34
NADPH acts as an endogenous P2X7 receptor modulator to gate neuroinflammatory responses of microglia	34
Co-inhibition of RAGE and TLR4 sensitizes pancreatic cancer to irreversible electroporation in mice by disrupting autophagy	33
Molecular recognition of two approved drugs Macimorelin and Anamorelin by the growth hormone secretagogue receptor	33
Z16b, a natural compound from Ganoderma cochlear is a novel RyR2 stabilizer preventing catecholaminergic polymorphic ventricular tachycardia	33
CP-25 enhances OAT1-mediated absorption of methotrexate in synoviocytes of collagen-induced arthritis rats	33
Identifying a non-conserved site for achieving allosteric covalent inhibition of CECR2	33
Esculetin facilitates post-stroke rehabilitation by inhibiting CKLF1-mediated neutrophil infiltration	32
ROCK1 inhibition improves wound healing in diabetes via RIPK4/AMPK pathway	32
Therapeutic potential and pharmacological mechanisms of Traditional Chinese Medicine in gout treatment	32
Wogonin attenuates septic cardiomyopathy by suppressing ALOX15-mediated ferroptosis	32
Scutellarin suppresses triple-negative breast cancer metastasis by inhibiting TNFα-induced vascular endothelial barrier breakdown	32
Cardiomyocyte peroxisome proliferator-activated receptor α prevents septic cardiomyopathy via improving mitochondrial function	31
Endothelial dysfunction: mechanisms and contribution to diseases	31
Proteomic characterization of post-translational modifications in drug discovery	31
Skullcapflavone II, a novel NQO1 inhibitor, alleviates aristolochic acid I-induced liver and kidney injury in mice	31
Circular RNA circDhx32 promotes cardiac inflammatory responses in mouse cardiac ischemia-reperfusion injury via binding to FOXO1 competed with AdipoR1	31
Author Correction: Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis	30
Serum amyloid A3 aggravates bleomycin-induced pulmonary fibrosis through Krüppel-like factor 6-dependent interlukin-36α expression	30
(+)-Borneol enantiomer ameliorates epileptic seizure via decreasing the excitability of glutamatergic transmission	30
Thioridazine protects against disturbed flow-induced atherosclerosis by inhibiting RhoA/YAP-mediated endothelial inflammation	30
Endothelial deubiquinatase YOD1 mediates Ang II-induced vascular endothelial-mesenchymal transition and remodeling by regulating β-catenin	30
Celastrol inhibits the DPYSL2-JAK/STAT pathway by targeting mito-IDHs mediated mitochondrial metabolism to exhaust breast cancer	30
G-protein coupled receptor kinase 2 mediates rheumatoid arthritis-induced depression-like behaviors via the hippocampal CRHR1 signaling pathway	30
Correction: Empagliflozin and liraglutide ameliorate HFpEF in mice via augmenting the Erbb4 signaling pathway	29
Dehydrocorydaline maintains the vascular smooth muscle cell contractile phenotype by upregulating Spta1	29
HER3 upregulation reduces DS-8201 sensitivity in HER2-positive tumor cells by ATR/CHK1/FoxO1 signaling cascade	29
Sirtuin 6 mitigates thoracic aortic aneurysm progression via maintenance of mitochondria homeostasis in vascular smooth muscle cells	29
Development of orthotopic mouse models for mid-low rectal cancer	29
Cardiovascular adverse effects of antiviral therapies for COVID-19: Evidence and plausible mechanisms	28
Inhibiting mPGES-2 impedes renal cyst growth in mice with polycystic kidney disease	28
Revisiting the role of GDF15 in atherosclerosis in mouse and human	28
Adaptor protein Src-homology 2 domain containing E (SH2E) deficiency induces heart defect in zebrafish	28
Electrophysiological characterization of human KCNT1 channel modulators and the therapeutic potential of hydroquinine and tipepidine in KCNT1 mutation-associated epilepsy mouse model	28
Discovery of a nitroaromatic nannocystin with potent in vivo anticancer activity against colorectal cancer by targeting AKT1	27
Dorsal raphe GABA-ergic neurons regulate the susceptibility to social transfer of pain in mice	27
Anti-diabetic drug canagliflozin hinders skeletal muscle regeneration in mice	27
c-FLIP promotes drug resistance in non-small-cell lung cancer cells via upregulating FoxM1 expression	27
zDHHC20-driven S-palmitoylation of CD80 is required for its costimulatory function	27
The role of microglia in neurodegenerative diseases: from the perspective of ferroptosis	27
Peptidoglycan isolated from the fruit of Lycium barbarum alleviates liver fibrosis in mice by regulating the TGF-β/Smad7 signaling and gut microbiota	26
Targeting PI3Kα overcomes resistance to KRasG12C inhibitors mediated by activation of EGFR and/or IGF1R	26
Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases	26
Bile acid and receptors: biology and drug discovery for nonalcoholic fatty liver disease	26
Caffeic acid phenethyl ester suppresses intestinal FXR signaling and ameliorates nonalcoholic fatty liver disease by inhibiting bacterial bile salt hydrolase activity	26
GFPBW1, a β-glucan from Grifola frondosa as vaccine adjuvant: APCs activation and maturation	26
Development of PI3Kγ selective inhibitors: the strategies and application	26
Aspirin modulates succinylation of PGAM1K99 to restrict the glycolysis through NF-κB/HAT1/PGAM1 signaling in liver cancer	25
Asiatic acid ameliorates doxorubicin-induced cardiotoxicity by promoting FPN-mediated iron export and inhibiting ferroptosis	25
Prenatal dexamethasone exposure impairs rat blood-testis barrier function and sperm quality in adult offspring via GR/KDM1B/FSTL3/TGFβ signaling	25
PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours	25
Author Correction: Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance	25
Poria cocos: traditional uses, triterpenoid components and their renoprotective pharmacology	25
Novel insights into NOD-like receptors in renal diseases	24
Gentiopicroside ameliorates psoriasis-like skin lesions in mice via regulating the Keap1-Nrf2 pathway and inhibiting keratinocyte activation	24
Pharmacological inhibition of FABP7 by MF 6 counteracts cerebellum dysfunction in an experimental multiple system atrophy mouse model	24
Luteolin ameliorates chronic stress-induced depressive-like behaviors in mice by promoting the Arginase-1+ microglial phenotype via a PPARγ-dependent mechanism	24
Hypocrellin A from an ethnic medicinal fungus protects against NLRP3-driven gout in mice by suppressing inflammasome activation	24
Exploring the constitutive activation mechanism of the class A orphan GPR20	24
GPR41 deficiency aggravates type 1 diabetes in streptozotocin-treated mice by promoting dendritic cell maturation	24
Multifaceted roles of UFMylation in health and disease	24
Targeting cholesterol metabolism: a promising therapy strategy for cancer	24
Inhibiting the Otub1/phosphorylated STAT3 axis for the treatment of non-small cell lung cancer	24
Atypical chemokine receptor 3 induces colorectal tumorigenesis in mice by promoting β-arrestin-NOLC1-fibrillarin-dependent rRNA biogenesis	24
Chronic β-adrenergic stress contributes to cardiomyopathy in rodents with collagen-induced arthritis	23
Cyclic GMP-AMP synthase recognizes the physical features of DNA	23
Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway	23
AXL antibody and AXL-ADC mediate antitumor efficacy via targeting AXL in tumor-intrinsic epithelial-mesenchymal transition and tumor-associated M2-like macrophage	23
DZ2002 alleviates corneal angiogenesis and inflammation in rodent models of dry eye disease via regulating STAT3-PI3K-Akt-NF-κB pathway	23
Targeted VEGFA therapy in regulating early acute kidney injury and late fibrosis	23
Betaine-homocysteine methyltransferase protects against acetaminophen-induced acute liver failure via BACH1-SCD1-oleic acid axis	23
Urolithin A ameliorates obesity-induced metabolic cardiomyopathy in mice via mitophagy activation	23
Inhibition of HIF-prolyl hydroxylase promotes renal tubule regeneration via the reprogramming of renal proximal tubular cells	22
Correction: A novel annexin dimer targets microglial phagocytosis of astrocytes to protect the brain-blood barrier after cerebral ischemia	22

Cardiac-specific deletion of BRG1 ameliorates ventricular arrhythmia in mice with myocardial infarction	22
Tigecycline suppresses colon cancer stem cells and impairs tumor engraftment by targeting SNAI1-regulated epithelial-mesenchymal transition	22
Somatostatin receptor 2 targeting peptide modifications for peptide-drug conjugate treatment of small cell lung cancer	22
Neuropeptide-mediated activation of astrocytes improves stress resilience in mice by modulating cortical neural synapses	22
Inhibition of Setd7 protects against cardiomyocyte hypertrophy via inhibiting lipid oxidation	22
Deep learning enables the discovery of a novel cuproptosis-inducing molecule for the inhibition of hepatocellular carcinoma	22
BMP1 inhibitor UK383367 improves MI-induced cardiac remodeling and fibrosis in mice via ameliorating macrophage polarization and mitochondrial dysfunction	21
NADPHnet: a novel strategy to predict compounds for regulation of NADPH metabolism via network-based methods	21
GluN2A-NMDA receptor inhibition disinhibits the prefrontal cortex, reduces forced swim immobility, and impairs sensorimotor gating	21
Notoginsenoside R1 protects against myocardial ischemia/reperfusion injury in mice via suppressing TAK1-JNK/p38 signaling	21
Inhibition of CD36 ameliorates mouse spinal cord injury by accelerating microglial lipophagy	21
Activation of D2-like dopamine receptors improves the neuronal network and cognitive function of PPT1KI mice	21
Brigatinib, a newly discovered AXL inhibitor, suppresses AXL-mediated acquired resistance to osimertinib in EGFR-mutated non-small cell lung cancer	21
The PIWI-interacting RNA CRAPIR alleviates myocardial ischemia‒reperfusion injury by reducing p53-mediated apoptosis via binding to SRSF1	21
Modeling exposure-driven adverse events of EGFR TKIs in the treatment of patients with non-small cell lung cancer	21
Adiponectin receptor agonist AdipoRon modulates human and mouse platelet function	21
Updates on novel pharmacotherapeutics for the treatment of nonalcoholic steatohepatitis	21
Characterization of LTr1 derived from cruciferous vegetables as a novel anti-glioma agent via inhibiting TrkA/PI3K/AKT pathway	21
Dl-3-n-butylphthalide promotes angiogenesis in ischemic stroke mice through upregulating autocrine and paracrine sonic hedgehog	20
Pentapeptide PYRAE triggers ER stress-mediated apoptosis of breast cancer cells in mice by targeting RHBDF1-BiP interaction	20
Formyl peptide receptor 2 is a potential biomarker and therapeutic target for inflammatory bowel disease	20
Circular RNA hsa_circ_0000288 protects against epilepsy in mice by binding to and stabilizing caprin1 protein	20
Novel Caspase-1 inhibitor CZL80 improves neurological function in mice after progressive ischemic stroke within a long therapeutic time-window	20
Decoding ligand recognition and constitutive activation of histamine H3 and H4 receptors	20
PHLDA1 contributes to hypoxic ischemic brain injury in neonatal rats via inhibiting FUNDC1-mediated mitophagy	20
Discovery of FO-4-15, a novel 1,2,4-oxadiazole derivative, ameliorates cognitive impairments in 3×Tg mice by activating the mGluR1/CaMKIIα pathway	20
Aberrant neuronal excitation promotes neuroinflammation in the primary motor cortex of ischemic stroke mice	20
ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway	20
Inhibiting the transcription and replication of Ebola viruses by disrupting the nucleoprotein and VP30 protein interaction with small molecules	20
Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis	20
Deubiquitinating enzyme USP11 promotes renal tubular cell senescence and fibrosis via inhibiting the ubiquitin degradation of TGF-β receptor II	19
Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson’s disease treatment	19
124I-labeled anti-CD147 antibody for noninvasive detection of CD147-positive pan-cancers: construction and preclinical studies	19
Indoxyl sulphate-TNFα axis mediates uremic encephalopathy in rodent acute kidney injury	19
AI-enhanced virtual screening approach to hit identification for GluN1/GluN3A NMDA receptor	19
Heat shock protein family A member 8 serving as a co-activator of transcriptional factor ETV4 up-regulates PHLDA2 to promote the growth of liver cancer	19
Discovery of novel GluN1/GluN3A NMDA receptor inhibitors using a deep learning-based method	19
USP11 promotes renal tubular cell pyroptosis and fibrosis in UUO mice via inhibiting KLF4 ubiquitin degradation	19
Thermoregulatory pathway underlying the pyrogenic effects of prostaglandin E2 in the lateral parabrachial nucleus of male rats	19
Chemokine CCL2 promotes cardiac regeneration and repair in myocardial infarction mice via activation of the JNK/STAT3 axis	19
An efficient deep learning-based strategy to screen inhibitors for GluN1/GluN3A receptor	19
A novel selective ERK1/2 inhibitor, Laxiflorin B, targets EGFR mutation subtypes in non-small-cell lung cancer	19
A novel small-molecule PCSK9 inhibitor E28362 ameliorates hyperlipidemia and atherosclerosis	18
Tetramethylpyrazine prevents liver fibrotic injury in mice by targeting hepatocyte-derived and mitochondrial DNA-enriched extracellular vesicles	18
Serum granulosa cell-derived TNF-α promotes inflammation and apoptosis of renal tubular cells and PCOS-related kidney injury through NF-κB signaling	18
Ivacaftor, a CFTR potentiator, synergizes with osimertinib against acquired resistance to osimertinib in NSCLC by regulating CFTR-PTEN-AKT axis	18
Targeting the 5-HT1B-YAP positive feedback loop protects against disturbed flow-induced atherogenesis in mice	18
Colchicine reduces neointima formation and VSMC phenotype transition by modulating SRF-MYOCD activation and autophagy	18
Dihydroartemisinin suppresses renal fibrosis in mice by inhibiting DNA-methyltransferase 1 and increasing Klotho	18
The aminosteroid U73122 promotes oligodendrocytes generation and myelin formation	18
ROS-induced degradation of hERG potassium channels contributes to aripiprazole-induced prolongation of the QTc interval	18
Role of thrombospondin-1 in high-salt–induced mesenteric artery endothelial impairment in rats	18
MMP-9 inhibitor SB-3CT improves neurological outcomes in ischemic stroke mice by modulation of astrocytic lipid metabolism	18
α-MSH-catabolic enzyme prolylcarboxypeptidase in nucleus accumbens shell ameliorates stress susceptibility in mice through regulating synaptic plasticity	18
Liver receptor homolog-1: structures, related diseases, and drug discovery	18
Mesenchymal stem cells in fibrotic diseases—the two sides of the same coin	17
Clobetasol propionate, a Nrf-2 inhibitor, sensitizes human lung cancer cells to radiation-induced killing via mitochondrial ROS-dependent ferroptosis	17
Norcantharidin promotes M1 macrophage polarization and suppresses colorectal cancer growth	17
Mass spectrometry imaging: new eyes on natural products for drug research and development	17
Activation of TRPV1 receptor facilitates myelin repair following demyelination via the regulation of microglial function	17
AI-driven breakthroughs in ion channel drug discovery: the future is now	17
6-Methyl flavone inhibits Nogo-B expression and improves high fructose diet-induced liver injury in mice	17
HDAC inhibitor GCJ-490A modulates tumor microenvironment and synergizes with PD-1 antibody against breast and lung cancers in syngeneic murine models	17
Disturbance of suprachiasmatic nucleus function improves cardiac repair after myocardial infarction by IGF2-mediated macrophage transition	17
Roles and related underlying mechanisms of mitochondrial RNA modification in cancer progression	17
GluD1 at the synaptic crossroads: from domain structure to circuit dysfunction	17
A structure-based virtual screening identifies a novel MDM2 antagonist in the activation of the p53 signaling and inhibition of tumor growth	17
O-GlcNAcylation mediates H2O2-induced apoptosis through regulation of STAT3 and FOXO1	16
CD200R blockade enhances anti-tumor immunity by unleashing NK and CD8+ T cells in tumor	16
Author Correction: Pharmacokinetics, mass balance, and metabolism of [14C]vicagrel, a novel irreversible P2Y12 inhibitor in humans	16
Autoimmune diseases: targets, biology, and drug discovery	16
Notoginsenoside R1 promotes Lgr5+ stem cell and epithelium renovation in colitis mice via activating Wnt/β-Catenin signaling	16
TGFβR-1/ALK5 inhibitor RepSox induces enteric glia-to-neuron transition and influences gastrointestinal mobility in adult mice	16
Cell senescence induced by toxic interaction between α-synuclein and iron precedes nigral dopaminergic neuron loss in a mouse model of Parkinson’s disease	16
YY1/HIF-1α/mROS positive-feedback loop exacerbates glomerular mesangial cell proliferation in mouse early diabetic kidney disease	16
Functional characterization and in vitro pharmacological rescue of KCNQ2 pore mutations associated with epileptic encephalopathy	16
Ceftazidime exhibits a broad inhibition to the infection of SARS-CoV-2 prototype and Omicron variant in vitro by blocking spike protein-ACE2 interaction	16
PACAP/PAC1-R activation contributes to hyperalgesia in 6-OHDA-induced Parkinson’s disease model rats via promoting excitatory synaptic transmission of spinal dorsal horn neurons	15
Discovery, evaluation and mechanism study of WDR5-targeted small molecular inhibitors for neuroblastoma	15
Uricolysis by Arthrobacter globiformis uricase: structural basis for its catalytic activity and thermostability	15
Author Correction: Paris saponin VII, a Hippo pathway activator, induces autophagy and exhibits therapeutic potential against human breast cancer cells	15
Deguelin inhibits growth and prolactin synthesis in prolactinomas by targeting the PI3K/AKT/CREB3L1 pathway and ornithine decarboxylase	15
Bile duct ligation impairs visual acuity in rats by ammonia- and bilirubin-induced retinal degeneration	15
Chromosome instability functions as a potential therapeutic reference by enhancing chemosensitivity to BCL-XL inhibitors in colorectal carcinoma	15
ATM promotes bone metastatic propensity of breast cancer by inducing osteoclastogenesis via the NFκB-CCL2 pathway	15
CD73 inhibitor AB680 suppresses glioblastoma in mice by inhibiting purine metabolism and promoting P2RY12+ microglia transformation	15
Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells	14
A novel FAK-degrading PROTAC molecule exhibited both anti-tumor activities and efficient MDR reversal effects	14
A novel monoacylglycerol lipase-targeted 18F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network	14
Apolipoprotein B100 acts as a tumor suppressor in ovarian cancer via lipid/ER stress axis-induced blockade of autophagy	14
SZC-6, a small-molecule activator of SIRT3, attenuates cardiac hypertrophy in mice	14
Pregnane X receptor activation alleviates renal fibrosis in mice via interacting with p53 and inhibiting the Wnt7a/β-catenin signaling	14
Epigenetic-based combination therapy and liposomal codelivery overcomes osimertinib-resistant NSCLC via repolarizing tumor-associated macrophages	14
Dysregulation of iron homeostasis by TfR-1 renders EZH2 wild type diffuse large B-cell lymphoma resistance to EZH2 inhibition	14
Targeting metabolism to enhance immunotherapy within tumor microenvironment	14