OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Pharmacologica Sinica is 43. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19	1530
Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients	303
Small molecule inhibitors targeting the PD-1/PD-L1 signaling pathway	193
Hypoxia, HIF-1α, and COVID-19: from pathogenic factors to potential therapeutic targets	149
Natural products: potential treatments for cisplatin-induced nephrotoxicity	142
Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma	135
Drp1-dependent mitochondrial fission in cardiovascular disease	128
Growth factors-based therapeutic strategies and their underlying signaling mechanisms for peripheral nerve regeneration	104
Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies	96
Caspase-11/4 and gasdermin D-mediated pyroptosis contributes to podocyte injury in mouse diabetic nephropathy	95
Engineering nanomedicines through boosting immunogenic cell death for improved cancer immunotherapy	91
Matrine attenuates pathological cardiac fibrosis via RPS5/p38 in mice	85
Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation	82
ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma	81
Baicalin prevents LPS-induced activation of TLR4/NF-κB p65 pathway and inflammation in mice via inhibiting the expression of CD14	66
Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases	62
Advanced biomaterials for cancer immunotherapy	60
Identification of SARS-CoV-2 entry inhibitors among already approved drugs	59
ATF3 contributes to brucine-triggered glioma cell ferroptosis via promotion of hydrogen peroxide and iron	58
Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia	58
Structure genomics of SARS-CoV-2 and its Omicron variant: drug design templates for COVID-19	58
Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer’s disease via inhibition of ACSL4-dependent ferroptosis	56
Ex vivo pulsed dendritic cell vaccination against cancer	56
NRF2-GPX4/SOD2 axis imparts resistance to EGFR-tyrosine kinase inhibitors in non-small-cell lung cancer cells	56
Nrf2 activation ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain	55

Deletion of TLR4 attenuates lipopolysaccharide-induced acute liver injury by inhibiting inflammation and apoptosis	54
Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabetic kidney disease	53
Luteolin alleviates cognitive impairment in Alzheimer’s disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation	53
Baicalein attenuates cardiac hypertrophy in mice via suppressing oxidative stress and activating autophagy in cardiomyocytes	52
Mitochondrial Ca2+ regulation in the etiology of heart failure: physiological and pathophysiological implications	51
DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress	51
Metformin and cancer immunity	50
New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer’s disease	50
Mutations in key driver genes of pancreatic cancer: molecularly targeted therapies and other clinical implications	50
Gut microbiota dysbiosis-induced activation of the intrarenal renin–angiotensin system is involved in kidney injuries in rat diabetic nephropathy	49
Baicalein ameliorates ulcerative colitis by improving intestinal epithelial barrier via AhR/IL-22 pathway in ILC3s	48
The glycolytic process in endothelial cells and its implications	47
Recombinant human ACE2: potential therapeutics of SARS-CoV-2 infection and its complication	47
Sirt1 inhibits renal tubular cell epithelial–mesenchymal transition through YY1 deacetylation in diabetic nephropathy	46
Harnessing nanomedicine to overcome the immunosuppressive tumor microenvironment	45
PEITC triggers multiple forms of cell death by GSH-iron-ROS regulation in K7M2 murine osteosarcoma cells	45
NOD-like receptors in autoimmune diseases	45
N-myristoylation: from cell biology to translational medicine	44
Zinc as a countermeasure for cadmium toxicity	43