OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Pharmacologica Sinica is 46. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Single-dose methamphetamine administration impairs ORM retrieval in mice via excessive DA-mediated inhibition of PrLGlu activity	303
Author Correction: Discovery of toxoflavin, a potent IRE1α inhibitor acting through structure-dependent oxidative inhibition	211
Reducing lipid peroxidation attenuates stress-induced susceptibility to herpes simplex virus type 1	157
Activating Wnt/β-catenin signaling by autophagic degradation of APC contributes to the osteoblast differentiation effect of soy isoflavone on osteoporotic mesenchymal stem cells	134
Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates	120
Identification of Licoflavone C as a cap-dependent endonuclease inhibitor against severe fever with thrombocytopenia syndrome virus	113
Translin deletion impairs cocaine-induced locomotor sensitization and RGS8 expression in the nucleus accumbens	112
MC1R and melanin-based molecular probes for theranostic of melanoma and beyond	104
Magnolin overcomes EGFR TKI resistance in NSCLC by modulation of NDRG1-NRG2-HECW1 pathway	99
Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition	96
Compound 38, a novel potent and selective antagonist of adenosine A2A receptor, enhances arousal in mice	94
S670, an amide derivative of 3-O-acetyl-11-keto-β-boswellic acid, induces ferroptosis in human glioblastoma cells by generating ROS and inhibiting STX17-mediated fusion of autophagosome and lysosome	87
Satellite cell-derived exosome-mediated delivery of microRNA-23a/27a/26a cluster ameliorates the renal tubulointerstitial fibrosis in mouse diabetic nephropathy	85
Celastrol suppresses the growth of vestibular schwannoma in mice by promoting the degradation of β-catenin	84
GRK2-mediated phosphorylation and de-succinylation of PKM2 reduce macrophage glycolysis in rheumatoid arthritis	84
Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren’s syndrome in mice by promoting TEC kinase degradation	82
tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis	76
Otilonium bromide ameliorates pulmonary fibrosis in mice through activating phosphatase PPM1A	75
Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson’s disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle	73
Cystathionine γ-lyase-derived H2S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase	70
Extracellular vesicles in vascular remodeling	69
Channelopathy of small- and intermediate-conductance Ca2+-activated K+ channels	68
Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-κB p65-activated SLC7A11 transcription	65
Pyroptosis and pyroptosis-inducing cancer drugs	65
Natural product-based screening led to the discovery of a novel PXR agonist with anti-cholestasis activity	64

The hybrid oncolytic peptide NTP-385 potently inhibits adherent cancer cells by targeting the nucleus	64
Targeted degradation of membrane and extracellular proteins with LYTACs	63
Transport mechanism and drug discovery of human monocarboxylate transporter 1	62
Correction to: EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells	61
Author Correction: ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway	61
Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation	60
Resibufogenin ameliorates cerebral ischemia-reperfusion injury by modulating microglial redox homeostasis via Keap1-Nrf2-TFR1/ARE axis	59
p52-ZER6: a determinant of tumor cell sensitivity to MDM2-p53 binding inhibitors	56
Insomnia-related rodent models in drug discovery	55
143D, a novel selective KRASG12C inhibitor exhibits potent antitumor activity in preclinical models	55
Retraction Note: Physcion inhibits the metastatic potential of human colorectal cancer SW620 cells in vitro by suppressing the transcription factor SOX2	54
Transcriptional regulation and small compound targeting of ACE2 in lung epithelial cells	52
Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer	51
Sortilin deletion in the prefrontal cortex and hippocampus ameliorates depressive-like behaviors in mice via regulating ASM/ceramide signaling	51
Thoracic perivascular adipose tissue inhibits VSMC apoptosis and aortic aneurysm formation in mice via the secretome of browning adipocytes	51
Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376	51
Antagonism of histamine H3 receptor promotes angiogenesis following focal cerebral ischemia	50
LN-439A, a novel BAP1 inhibitor, suppresses the growth of basal-like breast cancer by degrading KLF5	49
Liver X receptor inverse agonist SR9243 attenuates rheumatoid arthritis via modulating glycolytic metabolism of macrophages	48
Gastrodin promotes CNS myelinogenesis and alleviates demyelinating injury by activating the PI3K/AKT/mTOR signaling	48
Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial calcium-mediated renal tubular cell senescence	46