OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Pharmacologica Sinica is 45. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Author Correction: Discovery of toxoflavin, a potent IRE1α inhibitor acting through structure-dependent oxidative inhibition	270
Single-dose methamphetamine administration impairs ORM retrieval in mice via excessive DA-mediated inhibition of PrLGlu activity	181
ADT-OH inhibits malignant melanoma metastasis in mice via suppressing CSE/CBS and FAK/Paxillin signaling pathway	153
Compound 38, a novel potent and selective antagonist of adenosine A2A receptor, enhances arousal in mice	137
Channelopathy of small- and intermediate-conductance Ca2+-activated K+ channels	114
Translin deletion impairs cocaine-induced locomotor sensitization and RGS8 expression in the nucleus accumbens	102
Otilonium bromide ameliorates pulmonary fibrosis in mice through activating phosphatase PPM1A	100
Cystathionine γ-lyase-derived H2S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase	97
GRK2-mediated phosphorylation and de-succinylation of PKM2 reduce macrophage glycolysis in rheumatoid arthritis	96
Reducing lipid peroxidation attenuates stress-induced susceptibility to herpes simplex virus type 1	94
Activating Wnt/β-catenin signaling by autophagic degradation of APC contributes to the osteoblast differentiation effect of soy isoflavone on osteoporotic mesenchymal stem cells	88
Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson’s disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle	86
Satellite cell-derived exosome-mediated delivery of microRNA-23a/27a/26a cluster ameliorates the renal tubulointerstitial fibrosis in mouse diabetic nephropathy	86
Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition	83
Natural product-based screening led to the discovery of a novel PXR agonist with anti-cholestasis activity	79
tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis	78
S670, an amide derivative of 3-O-acetyl-11-keto-β-boswellic acid, induces ferroptosis in human glioblastoma cells by generating ROS and inhibiting STX17-mediated fusion of autophagosome and lysosome	76
Identification of Licoflavone C as a cap-dependent endonuclease inhibitor against severe fever with thrombocytopenia syndrome virus	73
Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates	72
Targeted degradation of membrane and extracellular proteins with LYTACs	68
Paris saponin VII, a Hippo pathway activator, induces autophagy and exhibits therapeutic potential against human breast cancer cells	67
Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren’s syndrome in mice by promoting TEC kinase degradation	67
The hybrid oncolytic peptide NTP-385 potently inhibits adherent cancer cells by targeting the nucleus	62
Pyroptosis and pyroptosis-inducing cancer drugs	60
Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-κB p65-activated SLC7A11 transcription	58

Celastrol suppresses the growth of vestibular schwannoma in mice by promoting the degradation of β-catenin	58
MC1R and melanin-based molecular probes for theranostic of melanoma and beyond	58
Extracellular vesicles in vascular remodeling	56
Author Correction: ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway	55
Transcriptional regulation and small compound targeting of ACE2 in lung epithelial cells	55
Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer	54
Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation	54
Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376	53
FX5, a non-steroidal glucocorticoid receptor antagonist, ameliorates diabetic cognitive impairment in mice	52
Flavokawain B alleviates LPS-induced acute lung injury via targeting myeloid differentiation factor 2	52
DNMT inhibition epigenetically restores the cGAS-STING pathway and activates RIG-I/MDA5-MAVS to enhance antitumor immunity	51
Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway	51
Liver X receptor inverse agonist SR9243 attenuates rheumatoid arthritis via modulating glycolytic metabolism of macrophages	51
143D, a novel selective KRASG12C inhibitor exhibits potent antitumor activity in preclinical models	50
Correction to: EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells	49
Transport mechanism and drug discovery of human monocarboxylate transporter 1	46
Insomnia-related rodent models in drug discovery	46
p52-ZER6: a determinant of tumor cell sensitivity to MDM2-p53 binding inhibitors	46
Dendritic cell-liposome conjugates reverse immunosuppressive tumor microenvironment for inhibiting colitis-associated colorectal cancer	45
Chronic infusion of ELABELA alleviates vascular remodeling in spontaneously hypertensive rats via anti-inflammatory, anti-oxidative and anti-proliferative effects	45
Gastrodin promotes CNS myelinogenesis and alleviates demyelinating injury by activating the PI3K/AKT/mTOR signaling	45