OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Pharmacologica Sinica is 50. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-07-01 to 2026-07-01.)

Article	Citations
Compound 38, a novel potent and selective antagonist of adenosine A2A receptor, enhances arousal in mice	378
The hybrid oncolytic peptide NTP-385 potently inhibits adherent cancer cells by targeting the nucleus	210
MC1R and melanin-based molecular probes for theranostic of melanoma and beyond	183
Author Correction: Discovery of toxoflavin, a potent IRE1α inhibitor acting through structure-dependent oxidative inhibition	166
Single-dose methamphetamine administration impairs ORM retrieval in mice via excessive DA-mediated inhibition of PrLGlu activity	117
Identification of Licoflavone C as a cap-dependent endonuclease inhibitor against severe fever with thrombocytopenia syndrome virus	116
Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren’s syndrome in mice by promoting TEC kinase degradation	116
Magnolin overcomes EGFR TKI resistance in NSCLC by modulation of NDRG1-NRG2-HECW1 pathway	115
Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition	110
Activating Wnt/β-catenin signaling by autophagic degradation of APC contributes to the osteoblast differentiation effect of soy isoflavone on osteoporotic mesenchymal stem cells	104
Satellite cell-derived exosome-mediated delivery of microRNA-23a/27a/26a cluster ameliorates the renal tubulointerstitial fibrosis in mouse diabetic nephropathy	101
Translin deletion impairs cocaine-induced locomotor sensitization and RGS8 expression in the nucleus accumbens	98
S670, an amide derivative of 3-O-acetyl-11-keto-β-boswellic acid, induces ferroptosis in human glioblastoma cells by generating ROS and inhibiting STX17-mediated fusion of autophagosome and lysosome	86
CSF1R inhibitor C19 for glioma immunotherapy enabled by brain-targeting liposomal delivery	85
Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson’s disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle	84
Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-κB p65-activated SLC7A11 transcription	83
Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates	82
Cystathionine γ-lyase-derived H2S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase	82
GRK2-mediated phosphorylation and de-succinylation of PKM2 reduce macrophage glycolysis in rheumatoid arthritis	82
Otilonium bromide ameliorates pulmonary fibrosis in mice through activating phosphatase PPM1A	82
Molecular mechanisms for sustaining cancer stem cells characteristics and targeted therapeutic strategies	81
Reducing lipid peroxidation attenuates stress-induced susceptibility to herpes simplex virus type 1	81
tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis	77
Targeted degradation of membrane and extracellular proteins with LYTACs	76
ER-phagy receptors: structural mechanisms in selective ER degradation and disease implications	72

143D, a novel selective KRASG12C inhibitor exhibits potent antitumor activity in preclinical models	71
Resibufogenin ameliorates cerebral ischemia-reperfusion injury by modulating microglial redox homeostasis via Keap1-Nrf2-TFR1/ARE axis	71
Insomnia-related rodent models in drug discovery	71
Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer	71
Cell-based cancer immunotherapy: milestones, mechanistic insights, and emerging therapeutic directions	69
Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation	69
p52-ZER6: a determinant of tumor cell sensitivity to MDM2-p53 binding inhibitors	68
Transport mechanism and drug discovery of human monocarboxylate transporter 1	65
TRADD-mediated pyroptosis contributes to diabetic cardiomyopathy	64
LN-439A, a novel BAP1 inhibitor, suppresses the growth of basal-like breast cancer by degrading KLF5	62
Author Correction: ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway	61
Correction to: EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells	61
Retraction Note: Physcion inhibits the metastatic potential of human colorectal cancer SW620 cells in vitro by suppressing the transcription factor SOX2	59
DNMT1-mediated central amygdala to locus coeruleus circuit contributes to chronic pain-related depression in mice	55
Exploring the distinct activation mechanisms of neuromedin B receptor through multiple replica molecular dynamics simulations and Markov state modeling	54
Thoracic perivascular adipose tissue inhibits VSMC apoptosis and aortic aneurysm formation in mice via the secretome of browning adipocytes	54
DNMT inhibition epigenetically restores the cGAS-STING pathway and activates RIG-I/MDA5-MAVS to enhance antitumor immunity	53
Gastrodin promotes CNS myelinogenesis and alleviates demyelinating injury by activating the PI3K/AKT/mTOR signaling	52
Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial calcium-mediated renal tubular cell senescence	52
Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway	51
Liver X receptor inverse agonist SR9243 attenuates rheumatoid arthritis via modulating glycolytic metabolism of macrophages	51
Melatonin ameliorates bleomycin-induced pulmonary fibrosis via activating NRF2 and inhibiting galectin-3 expression	50
Dendritic cell-liposome conjugates reverse immunosuppressive tumor microenvironment for inhibiting colitis-associated colorectal cancer	50
Pharmacological strategies to enhance the response of hepatoblastoma to chemotherapy through MDR1 inhibition	50
RIPK1 inhibition contributes to lysosomal membrane stabilization in ischemic astrocytes via a lysosomal Hsp70.1B-dependent mechanism	50
Contrastive learning-based drug screening model for GluN1/GluN3A inhibitors	50