OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Pharmacologica Sinica is 45. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren’s syndrome in mice by promoting TEC kinase degradation	236
Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition	142
Author Correction: Discovery of toxoflavin, a potent IRE1α inhibitor acting through structure-dependent oxidative inhibition	121
Natural product-based screening led to the discovery of a novel PXR agonist with anti-cholestasis activity	119
Celastrol suppresses the growth of vestibular schwannoma in mice by promoting the degradation of β-catenin	101
Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson’s disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle	95
Single-dose methamphetamine administration impairs ORM retrieval in mice via excessive DA-mediated inhibition of PrLGlu activity	92
Reducing lipid peroxidation attenuates stress-induced susceptibility to herpes simplex virus type 1	91
Identification of Licoflavone C as a cap-dependent endonuclease inhibitor against severe fever with thrombocytopenia syndrome virus	85
ADT-OH inhibits malignant melanoma metastasis in mice via suppressing CSE/CBS and FAK/Paxillin signaling pathway	84
Activating Wnt/β-catenin signaling by autophagic degradation of APC contributes to the osteoblast differentiation effect of soy isoflavone on osteoporotic mesenchymal stem cells	84
Otilonium bromide ameliorates pulmonary fibrosis in mice through activating phosphatase PPM1A	82
Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates	78
Satellite cell-derived exosome-mediated delivery of microRNA-23a/27a/26a cluster ameliorates the renal tubulointerstitial fibrosis in mouse diabetic nephropathy	75
Cystathionine γ-lyase-derived H2S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase	74
Channelopathy of small- and intermediate-conductance Ca2+-activated K+ channels	74
Role of TRPM2 in brain tumours and potential as a drug target	73
Extracellular vesicles in vascular remodeling	73
Compound 38, a novel potent and selective antagonist of adenosine A2A receptor, enhances arousal in mice	72
MC1R and melanin-based molecular probes for theranostic of melanoma and beyond	72
Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-κB p65-activated SLC7A11 transcription	65
Paris saponin VII, a Hippo pathway activator, induces autophagy and exhibits therapeutic potential against human breast cancer cells	64
Targeted degradation of membrane and extracellular proteins with LYTACs	62
The hybrid oncolytic peptide NTP-385 potently inhibits adherent cancer cells by targeting the nucleus	59
S670, an amide derivative of 3-O-acetyl-11-keto-β-boswellic acid, induces ferroptosis in human glioblastoma cells by generating ROS and inhibiting STX17-mediated fusion of autophagosome and lysosome	58

tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis	56
Pyroptosis and pyroptosis-inducing cancer drugs	56
Gastrodin promotes CNS myelinogenesis and alleviates demyelinating injury by activating the PI3K/AKT/mTOR signaling	55
Antagonism of histamine H3 receptor promotes angiogenesis following focal cerebral ischemia	53
Transport mechanism and drug discovery of human monocarboxylate transporter 1	53
Upregulation of wild-type p53 by small molecule-induced elevation of NQO1 in non-small cell lung cancer cells	53
Flavokawain B alleviates LPS-induced acute lung injury via targeting myeloid differentiation factor 2	53
FX5, a non-steroidal glucocorticoid receptor antagonist, ameliorates diabetic cognitive impairment in mice	51
Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer	51
Liver X receptor inverse agonist SR9243 attenuates rheumatoid arthritis via modulating glycolytic metabolism of macrophages	50
Transcriptional regulation and small compound targeting of ACE2 in lung epithelial cells	50
Author Correction: ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway	49
Chronic infusion of ELABELA alleviates vascular remodeling in spontaneously hypertensive rats via anti-inflammatory, anti-oxidative and anti-proliferative effects	48
143D, a novel selective KRASG12C inhibitor exhibits potent antitumor activity in preclinical models	48
LN-439A, a novel BAP1 inhibitor, suppresses the growth of basal-like breast cancer by degrading KLF5	48
Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376	48
Correction to: EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells	46
Identification of pimavanserin tartrate as a potent Ca2+-calcineurin-NFAT pathway inhibitor for glioblastoma therapy	46
Insomnia-related rodent models in drug discovery	46
Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation	45