OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Pharmacologica Sinica is 48. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Translin deletion impairs cocaine-induced locomotor sensitization and RGS8 expression in the nucleus accumbens	361
Otilonium bromide ameliorates pulmonary fibrosis in mice through activating phosphatase PPM1A	200
Cystathionine γ-lyase-derived H2S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase	180
Compound 38, a novel potent and selective antagonist of adenosine A2A receptor, enhances arousal in mice	160
Reducing lipid peroxidation attenuates stress-induced susceptibility to herpes simplex virus type 1	114
The hybrid oncolytic peptide NTP-385 potently inhibits adherent cancer cells by targeting the nucleus	114
MC1R and melanin-based molecular probes for theranostic of melanoma and beyond	111
Author Correction: Discovery of toxoflavin, a potent IRE1α inhibitor acting through structure-dependent oxidative inhibition	108
Single-dose methamphetamine administration impairs ORM retrieval in mice via excessive DA-mediated inhibition of PrLGlu activity	102
Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition	101
Identification of Licoflavone C as a cap-dependent endonuclease inhibitor against severe fever with thrombocytopenia syndrome virus	97
Satellite cell-derived exosome-mediated delivery of microRNA-23a/27a/26a cluster ameliorates the renal tubulointerstitial fibrosis in mouse diabetic nephropathy	95
Activating Wnt/β-catenin signaling by autophagic degradation of APC contributes to the osteoblast differentiation effect of soy isoflavone on osteoporotic mesenchymal stem cells	80
S670, an amide derivative of 3-O-acetyl-11-keto-β-boswellic acid, induces ferroptosis in human glioblastoma cells by generating ROS and inhibiting STX17-mediated fusion of autophagosome and lysosome	80
Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren’s syndrome in mice by promoting TEC kinase degradation	79
GRK2-mediated phosphorylation and de-succinylation of PKM2 reduce macrophage glycolysis in rheumatoid arthritis	78
Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates	78
ER-phagy receptors: structural mechanisms in selective ER degradation and disease implications	77
Magnolin overcomes EGFR TKI resistance in NSCLC by modulation of NDRG1-NRG2-HECW1 pathway	77
CSF1R inhibitor C19 for glioma immunotherapy enabled by brain-targeting liposomal delivery	76
Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson’s disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle	76
Targeted degradation of membrane and extracellular proteins with LYTACs	75
Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-κB p65-activated SLC7A11 transcription	74
tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis	70
Resibufogenin ameliorates cerebral ischemia-reperfusion injury by modulating microglial redox homeostasis via Keap1-Nrf2-TFR1/ARE axis	69

Channelopathy of small- and intermediate-conductance Ca2+-activated K+ channels	69
Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer	69
143D, a novel selective KRASG12C inhibitor exhibits potent antitumor activity in preclinical models	68
Insomnia-related rodent models in drug discovery	67
Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation	66
Exploring the distinct activation mechanisms of neuromedin B receptor through multiple replica molecular dynamics simulations and Markov state modeling	65
Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376	62
Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway	62
Dual-responsive nanoparticles loading bevacizumab and gefitinib for molecular targeted therapy against non-small cell lung cancer	61
Liver X receptor inverse agonist SR9243 attenuates rheumatoid arthritis via modulating glycolytic metabolism of macrophages	60
Dendritic cell-liposome conjugates reverse immunosuppressive tumor microenvironment for inhibiting colitis-associated colorectal cancer	59
Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial calcium-mediated renal tubular cell senescence	59
Cell-based cancer immunotherapy: milestones, mechanistic insights, and emerging therapeutic directions	57
p52-ZER6: a determinant of tumor cell sensitivity to MDM2-p53 binding inhibitors	55
Transport mechanism and drug discovery of human monocarboxylate transporter 1	52
TRADD-mediated pyroptosis contributes to diabetic cardiomyopathy	51
Author Correction: ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway	50
LN-439A, a novel BAP1 inhibitor, suppresses the growth of basal-like breast cancer by degrading KLF5	50
Correction to: EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells	50
Retraction Note: Physcion inhibits the metastatic potential of human colorectal cancer SW620 cells in vitro by suppressing the transcription factor SOX2	50
Thoracic perivascular adipose tissue inhibits VSMC apoptosis and aortic aneurysm formation in mice via the secretome of browning adipocytes	49
DNMT inhibition epigenetically restores the cGAS-STING pathway and activates RIG-I/MDA5-MAVS to enhance antitumor immunity	49
Gastrodin promotes CNS myelinogenesis and alleviates demyelinating injury by activating the PI3K/AKT/mTOR signaling	49
Contrastive learning-based drug screening model for GluN1/GluN3A inhibitors	48
AlphaFold3 versus experimental structures: assessment of the accuracy in ligand-bound G protein-coupled receptors	48
Fangchinoline-mediated autophagy inhibition amplifies antigen presentation and PD-1 blockade efficacy in lung cancer	48