OOIR: Observatory of International Research

Papers

(The H4-Index of Frontiers in Immunology is 123. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Myeloid-specific blockade of notch signaling alleviates dopaminergic neurodegeneration in Parkinson’s disease by dominantly regulating resident microglia activation through NF-κB signaling	704
Novel Allele Detection Tool Benchmark and Application With Antibody Repertoire Sequencing Dataset	473
Impact of BCG vaccination on the repertoire of human γδ T cell receptors	388
Capturing the multifaceted function of adipose tissue macrophages	338
Dual-Organ Transcriptomic Analysis of Rainbow Trout Infected With Ichthyophthirius multifiliis Through Co-Expression and Machine Learning	320
Atypical Ataxia Presentation in Variant Ataxia Telangiectasia: Iranian Case-Series and Review of the Literature	319
CD160 Promotes NK Cell Functions by Upregulating Glucose Metabolism and Negatively Correlates With HIV Disease Progression	290
The Therapeutic Potential for Targeting Group 2 Innate Lymphoid Cells in Asthma	289
The worthy role of hepatic arterial infusion chemotherapy in combination with anti-programmed cell death protein 1 monoclonal antibody immunotherapy in advanced hepatocellular carcinoma	288
Identification of NETs-related biomarkers and molecular clusters in systemic lupus erythematosus	284
Retinal response to systemic inflammation differs between sexes and neurons	277
Apoptosis in megakaryocytes: Safeguard and threat for thrombopoiesis	265
PLEKHA4 is a novel prognostic biomarker that reshapes the tumor microenvironment in lower-grade glioma	250
Fc receptors act as innate immune receptors during infection?	248
Hedgehog costimulation during ischemia-reperfusion injury potentiates cytokine and homing responses of CD4+ T cells	248
Role of nuclear receptor PXR in immune cells and inflammatory diseases	245
Perspectives of ERCC1 in early-stage and advanced cervical cancer: From experiments to clinical applications	232
Genetic deletion of HVEM in a leukemia B cell line promotes a preferential increase of PD-1- stem cell-like T cells over PD-1+ T cells curbing tumor progression	232
Editorial: Targeting key cellular signaling network for cancer chemotherapy and immunotherapy	231
The Immunological Roles of Olfactory Ensheathing Cells in the Treatment of Spinal Cord Injury	216
Removal of natural anti-αGal antibodies elicits protective immunity against Gram-negative bacterial infections	216
Salivary interleukin-17A and interferon-γ levels are elevated in children with food allergies in China	214
Investigating the impact of STING pathway activation on breast cancer treatment outcomes: development and validation of a prognostic model	214
Editorial: The gut-immune axis: a complex training ground impacting inflammatory pathologies	211
Profiling the T Cell Receptor Alpha/Delta Locus in Salmonids	209

Identification of cuproptosis-related subtypes, characterization of tumor microenvironment infiltration, and development of a prognosis model in breast cancer	206
Role of UFMylation in tumorigenesis and cancer immunotherapy	204
Identification and Validation of Immune Molecular Subtypes in Pancreatic Ductal Adenocarcinoma: Implications for Prognosis and Immunotherapy	202
The need for paradigm shift: prognostic significance and implications of standard therapy-related systemic immunosuppression in glioblastoma for immunotherapy and oncolytic virotherapy	196
Penpulimab, an Fc-Engineered IgG1 Anti-PD-1 Antibody, With Improved Efficacy and Low Incidence of Immune-Related Adverse Events	195
Whole-Process Treatment of Combined Small Cell Lung Cancer Initially Diagnosed as “Lung Squamous Cell Carcinoma”: A Case Report and Review of the Literature	192
Post Transplantation Bilirubin Nanoparticles Ameliorate Murine Graft Versus Host Disease via a Reduction of Systemic and Local Inflammation	188
Exploring the ROS reduction strategies in chronic lupus management	187
IL-21 is required for the maintenance and pathogenesis of murine Vγ4+ IL-17-producing γδT cells	187
Case Report: Suspected Case of Brucella-Associated Immune Reconstitution Inflammatory Syndrome	187
The PRotective Effect of Maternal Immunisation on preTerm birth: characterising the Underlying mechanisms and Role in newborn immune function: the PREMITUR study protocol	186
Study protocol: a prospective single-center study for non-invasive biomonitoring of renal complications in cancer patients treated with immune checkpoint inhibitors	181
Differential in vivo labeling with barcoded antibodies allows for simultaneous transcriptomic profiling of airway, lung tissue and intravascular immune cells	180
Case Report: Successful Treatment of Alopecia Universalis With Tofacitinib and Increased Cytokine Levels: Normal Therapeutic Reaction or Danger Signal?	179
SIRGs score may be a predictor of prognosis and immunotherapy response for esophagogastric junction adenocarcinoma	179
Anti-synthetase syndrome is associated with a higher risk of hospitalization among patients with idiopathic inflammatory myopathy and COVID-19	177
Editorial: Novel biomarkers for predicting response to cancer immunotherapy	176
Transcriptomic Analysis and C-Terminal Epitope Tagging Reveal Differential Processing and Signaling of Endogenous TLR3 and TLR7	175
What Function Do Platelets Play in Inflammation and Bacterial and Viral Infections?	175
Etanercept treatment for pediatric toxic epidermal necrolysis induced by deflazacort: a case report and literature review	175
Association between circulating leukocytes and arrhythmias: Mendelian randomization analysis in immuno-cardiac electrophysiology	174
Induction of IDO1 and Kynurenine by Serine Proteases Subtilisin, Prostate Specific Antigen, CD26 and HtrA: A New Form of Immunosuppression?	173
Human B-1 cells are important contributors to the naturally-occurring IgM pool against the tumor-associated ganglioside Neu5GcGM3	173
Post-SARS-CoV-2 infection and post-vaccine-related neurological complications share clinical features and the same positivity to anti-ACE2 antibodies	171
Editorial: Novel Platform for Antigen Delivery to Dendritic Cells for Immunotherapy	169
Vdelta1 T cells are more resistant than Vdelta2 T cells to the immunosuppressive properties of galectin-3	169
SRA inhibition improves antitumor potency of antigen-targeted chaperone vaccine	167
Global trends in research on MOG antibody-associated disease: bibliometrics and visualization analysis	165
Nomograms confirm serum IL-6 and CRP as predictors of immune checkpoint inhibitor efficacy in unresectable hepatocellular carcinoma	165
Understanding tissue-resident macrophages unlocks the potential for novel combinatorial strategies in breast cancer	164
Editorial: Dual role of inflammatory mediators in cancer immunotherapy	163
Immunological Findings and Clinical Outcomes of Infants With Positive Newborn Screening for Severe Combined Immunodeficiency From a Tertiary Care Center in the U.S.	163
Failure to decrease HbA1c levels following TB treatment is associated with elevated Th1/Th17 CD4+ responses	162
Serum metabolomic analysis reveals disorder of steroid hormone biosynthesis in patients with idiopathic inflammatory myopathy	162
Roles of Epithelial and Mesenchymal TRP Channels in Mediating Inflammatory Fibrosis	161
Editorial: Characterisation, functions and roles of antigen-specific regulatory T cells in health and disease	160
COL11A1 as an novel biomarker for breast cancer with machine learning and immunohistochemistry validation	160
Stereo electronic principles for selecting fully-protective, chemically-synthesised malaria vaccines	160
The Lung Alveolar Cell (LAC) miRNome and Gene Expression Profile of the SP-A-KO Mice After Infection With and Without Rescue With Human Surfactant Protein-A2 (1A0)	160
Editorial: Heterogeneity of ILC2s	159
Determining the Optimal (Neo)Adjuvant Regimen for Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer Regarding Survival Outcome: A Network Meta-Analysis	158
Amelioration of Beta Interferon Inhibition by NS4B Contributes to Attenuating Tembusu Virus Virulence in Ducks	158
Longitudinal analysis of immunocyte responses and inflammatory cytokine profiles in SFTSV-infected rhesus macaques	156
Pan-cancer analysis reveals MTTP as a prognostic and immunotherapeutic biomarker in human tumors	154
Editorial: Gasdermins in the defense against pathogens	153
The potential role of cfDNA-related innate immune responses in postoperative bone loss after alveolar bone grafting	152
Editorial: Broadening our view on nucleic acid sensing: novel sensors, signaling pathways, and involvement in non-infectious diseases	151
Case Report: A myasthenia gravis patient complicated with renal failure was effectively treated with efgartigimod	151
SARS-CoV-2 pre-exposure prophylaxis with tixagevimab/cilgavimab (AZD7442) provides protection in inborn errors of immunity with antibody defects: a real-world experience	150
Soluble Fc Receptor for IgM in Sera From Subsets of Patients With Chronic Lymphocytic Leukemia as Determined by a New Mouse Monoclonal Antibody	149

Tumor-associated CD8+T cell tolerance induced by erythroid progenitor cells	149
Inhibiting SIRT-2 by AK-7 restrains airway inflammation and oxidative damage promoting lung resurgence through NF-kB and MAP kinase signaling pathway	148
Experimental Models of Infectious Pulmonary Complications Following Hematopoietic Cell Transplantation	148
Long Non-Coding RNA- Associated Competing Endogenous RNA Axes in T-Cells in Multiple Sclerosis	148
Intracellular NAD+ Depletion Confers a Priming Signal for NLRP3 Inflammasome Activation	147
Defining a Methylation Signature Associated With Operational Tolerance in Kidney Transplant Recipients	147
A Potent and Protective Human Neutralizing Antibody Against SARS-CoV-2 Variants	147
Editorial: The role of toll-like receptors and their related signaling pathways in viral infection and inflammation	143
Editorial: Ubiquitin and ubiquitin-like modifications in viral infection and innate immunity	142
A specific immune signature for predicting the prognosis of glioma patients with IDH1-mutation and guiding immune checkpoint blockade therapy	141
Tetanus-diphtheria vaccine can prime SARS-CoV-2 cross-reactive T cells	140
Metabolic Controls on Epigenetic Reprogramming in Regulatory T Cells	140
A novel inflammation-related lncRNAs prognostic signature identifies LINC00346 in promoting proliferation, migration, and immune infiltration of glioma	138
Single-cell detection of primary transcripts, their genomic loci and nuclear factors by 3D immuno-RNA/DNA FISH in T cells	138
Vaccine Can Induce CD4-Mediated Responses to Homocitrullinated Peptides via Multiple HLA-Types and Confer Anti-Tumor Immunity	138
In-Depth Immunophenotyping With Mass Cytometry During TB Treatment Reveals New T-Cell Subsets Associated With Culture Conversion	137
Neonatal overfeeding attenuates microgliosis and hippocampal damage in an infant rat model of pneumococcal meningitis	137
Editorial: Community series in the role of angiogenesis and immune response in tumor microenvironment of solid tumor, volume III	135
The roles of AIM2 in neurodegenerative diseases: insights and therapeutic implications	134
Case Report: Real NPSLE? A patient with systemic sclerosis overlapping systemic lupus erythematosus presenting as epilepsy	134
Knowledge, attitude, and practice of Chinese parents with infants (aged 0–3 years) toward immunity, gut microbiota and biotics: a comprehensive study	134
Case report: Excessive daytime sleepiness as a presenting manifestation of autoimmune glial fibrillary acidic protein astrocytopathy	132
Single-Dose 13-Valent Conjugate Pneumococcal Vaccine in People Living With HIV – Immunological Response and Protection	131
Celiac disease - a pluripathological model in pediatric practice	131
A strategy to reconstitute immunity without GVHD via adoptive allogeneic Tscm therapy	130
Intratumoral high endothelial venules in solid tumors: a pooled study	130
Poly I:C elicits broader and stronger humoral and cellular responses to a Plasmodium vivax circumsporozoite protein malaria vaccine than Alhydrogel in mice	130
Editorial: Host-virus interaction at the omics and ecology levels	129
Overload of the Temporomandibular Joints Accumulates γδ T Cells in a Mouse Model of Rheumatoid Arthritis: A Morphological and Histological Evaluation	129
The anti-inflammatory and tolerogenic potential of small spleen peptides	129
Harnessing the potential of the NALT and BALT as targets for immunomodulation using engineering strategies to enhance mucosal uptake	129
Causal associations between Helicobacter Pylori infection and the risk and symptoms of Parkinson’s disease: a Mendelian randomization study	128
Counterproductive effects of anti-CD38 and checkpoint inhibitor for the treatment of NK/T cell lymphoma	128
ATM-TCR: TCR-Epitope Binding Affinity Prediction Using a Multi-Head Self-Attention Model	128
Frequency, characteristics, and immunological accompaniments of ataxia in anti-NMDAR antibody-associated encephalitis	127
PD-1-siRNA Delivered by Attenuated Salmonella Enhances the Antitumor Effect of Chloroquine in Colon Cancer	127
Expansion of Immature Neutrophils During SIV Infection Is Associated With Their Capacity to Modulate T-Cell Function	127
Evaluation of porcine GM-CSF during PRRSV infection in vitro and in vivo indicating a protective role of GM-CSF related with M1 biased activation in alveolar macrophage during PRRSV infection	127
Respiratory syncytial virus vaccination among US adults aged ≥60 years	126
Disrupted balance between pro-inflammatory lipid mediators and anti-inflammatory specialized pro-resolving mediators is linked to hyperinflammation in patients with alcoholic hepatitis	126
Effects of serial radon spa therapy on pain and peripheral immune status in patients suffering from musculoskeletal disorders– results from a prospective, randomized, placebo-controlled trial	125
Advantages of the zebrafish tumor xenograft model: the evaluation of efficacy in cancer therapy and the application to the study of lncRNAs	125
Picolinate-mediated immunomodulation: insights from Mendelian randomization on the role of NK cell percentage in the pathogenesis of lichen planus	125
Identification of key biomarkers related to fibrocartilage chondrocytes for osteoarthritis based on bulk, single-cell transcriptomic data	124
Macrophage-derived extracellular vesicles from Ascaris lumbricoides antigen exposure enhance Mycobacterium tuberculosis growth control, reduce IL-1β, and contain miR-342-5p, miR-516b-5p, and miR-570-3	124
Elevated circulating group-2 innate lymphoid cells expressing activation markers and correlated tryptase AB1 levels in active ascariasis	124
Bridging Computational Vaccinology and Vaccine Development Through Systematic Identification, Characterization, and Downselection of Conserved and Variable Circumsporozoite Protein CD4 T Cell Epitopes	123
Functional Characterization of Glycoprotein Nonmetastatic Melanoma Protein B in Scleroderma Fibrosis	123
Novel qEEG Biomarker to Distinguish Anti-NMDAR Encephalitis From Other Types of Autoimmune Encephalitis	123