OOIR: Observatory of International Research

Papers

(The H4-Index of Frontiers in Immunology is 124. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
IDO1-AhR axis increases T regulatory cells in Plasmodium vivax malaria infection	585
Comparative efficacy and safety of induction therapy in solid organ transplantation: a systematic review and network meta-analysis	394
Comprehensive analysis of phosducin-like 3 as a diagnostic, prognostic and immunological marker in pan-cancer	390
Regulation of cancer by inflammasomes: from inflammation to tumorigenesis	354
miR-107-enriched exosomes promote ROS/wnt/autophagy, inhibit intracellular mycobacterial growth and attenuate lung infection	348
Leveraging the integration of bioinformatics and machine learning to uncover common biomarkers and molecular pathways underlying diabetes and nephrolithiasis	339
Oncostatin M enhances the lengthening of sensory nerves and skin hypersensitivity	330
Modulation of the immune microenvironment using nanomaterials: a new strategy for tumor immunotherapy	294
Serum metabolomic analysis reveals disorder of steroid hormone biosynthesis in patients with idiopathic inflammatory myopathy	292
Editorial: The Immunology of Adverse Drug Reactions	282
SARS-CoV-2 Spike Protein Expression In Vitro and Hematologic Effects in Mice Vaccinated With AZD1222 (ChAdOx1 nCoV-19)	280
Penpulimab, an Fc-Engineered IgG1 Anti-PD-1 Antibody, With Improved Efficacy and Low Incidence of Immune-Related Adverse Events	256
Proteomic and Metabolomic Characterization of SARS-CoV-2-Infected Cynomolgus Macaque at Early Stage	256
Hsa_Circ_0066351 Acts as a Prognostic and Immunotherapeutic Biomarker in Colorectal Cancer	253
Safety of JAK and IL-6 inhibitors in patients with rheumatoid arthritis: a multicenter cohort study	251
Histone acetylation-related IncRNA: Potential biomarkers for predicting prognosis and immune response in lung adenocarcinoma, and distinguishing hot and cold tumours	249
Different cytokine and chemokine profiles in hospitalized patients with COVID-19 during the first and second outbreaks from Argentina show no association with clinical comorbidities	247
IL-12α deficiency attenuates pressure overload-induced cardiac inflammation, hypertrophy, dysfunction, and heart failure progression	244
Long-Term Suppression of Circulating Proinflammatory Cytokines in Multiple Sclerosis Patients Following Autologous Haematopoietic Stem Cell Transplantation	243
Eosinophil is a predictor of severe immune-related adverse events induced by ipilimumab plus nivolumab therapy in patients with renal cell carcinoma: a retrospective multicenter cohort study	240
Early immune profiling reveals distinct inflammatory responses between children and adults few days after primary SARS-CoV-2 infection	239
Escalating SARS-CoV-2 specific humoral immune response in rheumatoid arthritis patients and healthy controls	238
Discovery of an independent poor-prognosis subtype associated with tertiary lymphoid structures in breast cancer	236
Identification of diagnostic genes and drug prediction in metabolic syndrome-associated rheumatoid arthritis by integrated bioinformatics analysis, machine learning, and molecular docking	228
Atypical Ataxia Presentation in Variant Ataxia Telangiectasia: Iranian Case-Series and Review of the Literature	223

Pathogenic Roles of CXCL10 in Experimental Autoimmune Prostatitis by Modulating Macrophage Chemotaxis and Cytokine Secretion	218
Case report: Efgartigimod is a novel therapeutic option for ocular myasthenia gravis: a report of 2 cases	212
The impact of persistent organic pollutants on fertility: exposure to the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin alters reproductive tract immune responses	210
Poly I:C elicits broader and stronger humoral and cellular responses to a Plasmodium vivax circumsporozoite protein malaria vaccine than Alhydrogel in mice	210
The role of γδT lymphocytes in atherosclerosis	206
Profiling the T Cell Receptor Alpha/Delta Locus in Salmonids	205
Editorial: Gut dysbiosis-induced systemic inflammation in neurological diseases and disorders	202
LPS Stimulation Induces Small Heterodimer Partner Expression Through the AMPK-NRF2 Pathway in Large Yellow Croaker (Larimichthys crocea)	200
Functional Effects of Receptor-Binding Domain Mutations of SARS-CoV-2 B.1.351 and P.1 Variants	199
Chronic Kidney Failure Provokes the Enrichment of Terminally Differentiated CD8+ T Cells, Impairing Cytotoxic Mechanisms After Kidney Transplantation	198
PRRX1 Is a Novel Prognostic Biomarker and Facilitates Tumor Progression Through Epithelial–Mesenchymal Transition in Uveal Melanoma	197
The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation	196
The Lung Alveolar Cell (LAC) miRNome and Gene Expression Profile of the SP-A-KO Mice After Infection With and Without Rescue With Human Surfactant Protein-A2 (1A0)	195
mTOR Signaling Pathway Regulates the Release of Proinflammatory Molecule CCL5 Implicated in the Pathogenesis of Autism Spectrum Disorder	191
IL-27 Mediates Pro-Inflammatory Effects via the ERK Signaling Pathway During Preterm Labor	189
Seminal Plasma and Seminal Plasma Exosomes of Aged Male Mice Affect Early Embryo Implantation via Immunomodulation	188
Low-Dose Acetylsalicylic Acid Reduces T Cell Immune Activation: Potential Implications for HIV Prevention	188
Blood filtering system for COVID-19 management: novel modality of the cytokine storm therapeutics	187
Immunity against Delta and Omicron variants elicited by homologous inactivated vaccine booster in kidney transplant recipients	185
Different responses involving Tfh cells delay parasite-specific antibody production in Trypanosoma cruzi acute experimental models	184
Immune modulatory stem cells represent a significant component of the immune system	184
Interactions with and activation of immune cells by CD41a+ extracellular vesicles	183
Proteomic and metabolomic analysis of serum in women infected with COVID-19 during late pregnancy	182
Exploring the effects of dietary methionine supplementation on European seabass mucosal immune responses against Tenacibaculum maritimum	181
Molecular screening of transitional B cells as a prognostic marker of improved graft outcome and reduced rejection risk in kidney transplant	181
A distinct immune landscape in anti-synthetase syndrome profiled by a single-cell genomic study	181
A strategy to reconstitute immunity without GVHD via adoptive allogeneic Tscm therapy	181
Brain FADE syndrome: the final common pathway of chronic inflammation in neurological disease	180
HDL-C as a novel predictor of immune reconstitution in people living with HIV: insights from a baseline-to-dynamic change cohort study in China, 2005–2022	179
Investigation of GPR137C as a promising novel marker for the progression of prostate cancer through G4 screen and bioinformatics analyses	176
Development of a Phagocytosis-Dependent Gene Signature to Predict Prognosis and Response to Checkpoint Inhibition in Clear-Cell Renal Cell Carcinoma	172
Single-Cell RNA-seq Analysis Reveals Cellular Functional Heterogeneity in Dermis Between Fibrotic and Regenerative Wound Healing Fates	171
Immunogenomic Landscape in Breast Cancer Reveals Immunotherapeutically Relevant Gene Signatures	169
Marek’s disease virus-specific T cells proliferate, express antiviral cytokines but have impaired degranulation response	167
Tipping the balance between erythroid cell differentiation and induction of anemia in response to the inflammatory pathology associated with chronic trypanosome infections	167
Immunoinformatics Approach Toward the Introduction of a Novel Multi-Epitope Vaccine Against Clostridium difficile	166
Patients with juvenile idiopathic arthritis have decreased clonal diversity in the CD8+ T cell repertoire response to influenza vaccination	164
Structural basis for the broad and potent cross-reactivity of an N501Y-centric antibody against sarbecoviruses	164
Delayed diagnosis of the full triad autoimmune polyendocrine syndrome type 2 with adrenal crisis: a case report and literature review	162
Case report: Reversible splenial lesion syndrome preceding the onset of multiple sclerosis	162
Divergent COVID-19 Disease Trajectories Predicted by a DAMP-Centered Immune Network Model	161
Longitudinal analysis of immunocyte responses and inflammatory cytokine profiles in SFTSV-infected rhesus macaques	160
A bivalent self-amplifying RNA vaccine against yellow fever and Zika viruses	160
Tumor-associated CD8+T cell tolerance induced by erythroid progenitor cells	159
Syntaxin-4 and SNAP23 are involved in neutrophil degranulation, but not in the release of mitochondrial DNA during NET formation	158
Good Tumor Response to Chemoradioimmunotherapy in dMMR/MSI-H Advanced Colorectal Cancer: A Case Series	158
Disparate viral pandemics from COVID19 to monkeypox and beyond: a simple, effective and universal therapeutic approach hiding in plain sight	158
The mechanisms and factors that induce trained immunity in arthropods and mollusks	153
Antigen-specific T helper cells and cytokine profiles predict intensity and longevity of cellular and humoral responses to SARS-CoV-2 booster vaccination	152
The ΔfbpAΔsapM candidate vaccine derived from Mycobacterium tuberculosis H37Rv is markedly immunogenic in macrophages and induces robust immunity to tuberculosis in mice	151

Integrative single-cell analysis of longitudinal t(8;21) AML reveals heterogeneous immune cell infiltration and prognostic signatures	151
Editorial: Pemphigus and pemphigoid diseases: in memoriam Detlef Zillikens	150
Altered distribution and function of NK-cell subsets lead to impaired tumor surveillance in JAK2V617F myeloproliferative neoplasms	148
Advancing mRNA technologies for therapies and vaccines: An African context	147
Editorial: Characterisation, functions and roles of antigen-specific regulatory T cells in health and disease	146
Apoptosis in megakaryocytes: Safeguard and threat for thrombopoiesis	145
Haematopoietic Stem Cell Transplantation Results in Extensive Remodelling of the Clonal T Cell Repertoire in Multiple Sclerosis	145
Long Non-Coding RNA- Associated Competing Endogenous RNA Axes in T-Cells in Multiple Sclerosis	144
Case Report: Successful Treatment of Alopecia Universalis With Tofacitinib and Increased Cytokine Levels: Normal Therapeutic Reaction or Danger Signal?	144
Transcutaneous Vagal Nerve Stimulation Alone or in Combination With Radiotherapy Stimulates Lung Tumor Infiltrating Lymphocytes But Fails to Suppress Tumor Growth	144
Neutrophil heterogeneity in complement C1q expression associated with sepsis mortality	144
Microbiota-Derived Propionate Modulates Megakaryopoiesis and Platelet Function	143
NK cells from COVID-19 positive patients exhibit enhanced cytotoxic activity upon NKG2A and KIR2DL1 blockade	143
Current Strategies to Modulate Regulatory T Cell Activity in Allergic Inflammation	142
Editorial: Heterogeneity of ILC2s	141
Increased interleukin-9 and Th9 cells in patients with refractory Graves’ disease and interleukin-9 polymorphisms are associated with autoimmune thyroid diseases	141
Low-dose administration of prednisone has a good effect on the treatment of prolonged hematologic toxicity post-CD19 CAR-T cell therapy	141
Identification of Vancomycin Resistance in Methicillin-resistant Staphylococcus aureus in two macaque species and decolonization and long-term prevention of recolonization in Cynomolgus Macaques (Maca	139
HLA molecular mismatches and induced donor-specific tolerance in combined living donor kidney and hematopoietic stem cell transplantation	139
Editorial: The gut-immune axis: a complex training ground impacting inflammatory pathologies	138
Anti-synthetase syndrome is associated with a higher risk of hospitalization among patients with idiopathic inflammatory myopathy and COVID-19	138
Identification and validation of mitophagy-related genes in acute myocardial infarction and ischemic cardiomyopathy and study of immune mechanisms across different risk groups	137
MediMer: a versatile do-it-yourself peptide-receptive MHC class I multimer platform for tumor neoantigen-specific T cell detection	137
Reduced B cell frequencies in cord blood of HIV-exposed uninfected infants: an immunological and transcriptomic analysis	137
GPX8 regulates pan-apoptosis in gliomas to promote microglial migration and mediate immunotherapy responses	136
A comprehensive neuroimaging review of the primary and metastatic brain tumors treated with immunotherapy: current status, and the application of advanced imaging approaches and artificial intelligenc	136
The mARS complex: a critical mediator of immune regulation and homeostasis	135
Prevalence and duration of SARS-CoV-2 fecal shedding in breastfeeding dyads following maternal COVID-19 diagnosis	135
Advantages of the zebrafish tumor xenograft model: the evaluation of efficacy in cancer therapy and the application to the study of lncRNAs	134
Identification of cellular senescence-related genes and immune cell infiltration characteristics in intervertebral disc degeneration	133
Editorial: Exploring the role of T helper cells in autoimmune disease	133
Multidisciplinary approach to treating complex immune dysregulation disorders: an adaptive model for institutional implementation	133
Yorkie Negatively Regulates the Expression of Antimicrobial Proteins by Inducing Cactus Transcription in Prawns Macrobrachium nipponense	132
Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C	131
Imidazoquinolines with improved pharmacokinetic properties induce a high IFNα to TNFα ratio in vitro and in vivo	130
Nur77 and PPARγ regulate transcription and polarization in distinct subsets of M2-like reparative macrophages during regenerative inflammation	130
Biomarkers of fibrosis, kidney tissue injury and inflammation may predict severity and outcome of renal ANCA – associated vasculitis	130
The KIR repertoire of a West African chimpanzee population is characterized by limited gene, allele, and haplotype variation	130
Frequency, characteristics, and immunological accompaniments of ataxia in anti-NMDAR antibody-associated encephalitis	130
A new personalized vaccine strategy based on inducing the pyroptosis of tumor cells in vivo by transgenic expression of a truncated GSDMD N-terminus	129
Systematic Mendelian randomization study of the effect of gut microbiome and plasma metabolome on severe COVID-19	129
Nucleic acid-sensing toll-like receptors: Important players in Sjögren’s syndrome	129
Nomograms confirm serum IL-6 and CRP as predictors of immune checkpoint inhibitor efficacy in unresectable hepatocellular carcinoma	129
PLCγ2 controls neutrophil-like cell sensitivity through calcium oscillation and gates chemoattractant concentration range for chemotaxis	129
The Impact of Age Difference on the Efficacy and Safety of COVID-19 Vaccines: A Systematic Review and Meta-Analysis	128
High Salt Induces a Delayed Activation of Human Neutrophils	126
Lactobacillus spp. act in synergy to attenuate splenomegaly and lymphadenopathy in lupus-prone MRL/lpr mice	126
Comparative efficacy and safety of different recommended doses of telitacicept in patients with systemic lupus erythematosus in China: a systematic review and meta-analysis	125
Interferon therapy and its association with depressive disorders – A review	125
Neutrophil extracellular traps and macrophage activation contibute to thrombosis and post-covid syndrome in SARS-CoV-2 infection	124
Identification and Clinical Validation of Key Extracellular Proteins as the Potential Biomarkers in Relapsing-Remitting Multiple Sclerosis	124
Role of SARS-CoV-2-specific memory B cells promoting immune protection after booster vaccination in solid organ transplantation	124