Frontiers in Immunology

Papers
(The H4-Index of Frontiers in Immunology is 128. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)
ArticleCitations
Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)1679
The COVID-19 Cytokine Storm; What We Know So Far1106
Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies762
Tumor-Associated Macrophages in Tumor Immunity742
The Genus Alistipes: Gut Bacteria With Emerging Implications to Inflammation, Cancer, and Mental Health731
Immune Response, Inflammation, and the Clinical Spectrum of COVID-19475
Cancer Stem Cells—Origins and Biomarkers: Perspectives for Targeted Personalized Therapies422
The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses412
Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation376
A Review of the Progress and Challenges of Developing a Vaccine for COVID-19346
Cytokine Storm in COVID-19—Immunopathological Mechanisms, Clinical Considerations, and Therapeutic Approaches: The REPROGRAM Consortium Position Paper346
IOBR: Multi-Omics Immuno-Oncology Biological Research to Decode Tumor Microenvironment and Signatures327
Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)324
Overview of Immune Response During SARS-CoV-2 Infection: Lessons From the Past321
Targeting the NLRP3 Inflammasome in Severe COVID-19316
The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology315
The Tumor Microenvironment in the Response to Immune Checkpoint Blockade Therapies314
Redefining Tumor-Associated Macrophage Subpopulations and Functions in the Tumor Microenvironment312
Targeting Inflammation Driven by HMGB1310
Comparative Review of SARS-CoV-2, SARS-CoV, MERS-CoV, and Influenza A Respiratory Viruses305
The SARS-CoV-2 Spike Glycoprotein Biosynthesis, Structure, Function, and Antigenicity: Implications for the Design of Spike-Based Vaccine Immunogens297
Phagocytosis: Our Current Understanding of a Universal Biological Process284
Mucosal Immunity in COVID-19: A Neglected but Critical Aspect of SARS-CoV-2 Infection282
Interferon-α2b Treatment for COVID-19281
Relationships Between Immune Landscapes, Genetic Subtypes and Responses to Immunotherapy in Colorectal Cancer275
Pulmonary Innate Immune Response Determines the Outcome of Inflammation During Pneumonia and Sepsis-Associated Acute Lung Injury272
Gut Microbiota as a Trigger for Metabolic Inflammation in Obesity and Type 2 Diabetes269
Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body268
Maternal Immunological Adaptation During Normal Pregnancy260
Interplay Between NLRP3 Inflammasome and Autophagy258
Interaction of Microglia and Astrocytes in the Neurovascular Unit254
The Intestinal Microbiota and Colorectal Cancer249
Dendritic Cells and Their Role in Immunotherapy245
Highlight of Immune Pathogenic Response and Hematopathologic Effect in SARS-CoV, MERS-CoV, and SARS-Cov-2 Infection241
The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis237
The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria236
The Potential Impact of Zinc Supplementation on COVID-19 Pathogenesis233
COVID-19 Coronavirus Vaccine Design Using Reverse Vaccinology and Machine Learning232
Myeloid Cell-Derived Arginase in Cancer Immune Response230
The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System217
Crosstalk Between Astrocytes and Microglia: An Overview216
Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint211
The Rise of Non-Tuberculosis Mycobacterial Lung Disease211
Interleukin-6 Is a Biomarker for the Development of Fatal Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia211
Reaction of Human Monoclonal Antibodies to SARS-CoV-2 Proteins With Tissue Antigens: Implications for Autoimmune Diseases210
NF-κB: At the Borders of Autoimmunity and Inflammation205
T Helper (Th) Cell Profiles in Pregnancy and Recurrent Pregnancy Losses: Th1/Th2/Th9/Th17/Th22/Tfh Cells205
Mucins in Intestinal Mucosal Defense and Inflammation: Learning From Clinical and Experimental Studies203
Localized Interleukin-12 for Cancer Immunotherapy202
SARS-CoV-2 Accessory Proteins in Viral Pathogenesis: Knowns and Unknowns198
Serological Approaches for COVID-19: Epidemiologic Perspective on Surveillance and Control196
Neutrophils in COVID-19195
Immune-Boosting, Antioxidant and Anti-inflammatory Food Supplements Targeting Pathogenesis of COVID-19194
Human Immune Responses to Adeno-Associated Virus (AAV) Vectors193
A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease191
Colorectal Cancer Immunotherapy: Options and Strategies187
The New Era of Cancer Immunotherapy: Targeting Myeloid-Derived Suppressor Cells to Overcome Immune Evasion183
Humoral Responses and Serological Assays in SARS-CoV-2 Infections180
Crosstalk Between the MSI Status and Tumor Microenvironment in Colorectal Cancer179
ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19175
Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19175
Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions175
The Nexus Between Periodontal Inflammation and Dysbiosis174
The Long Road Toward COVID-19 Herd Immunity: Vaccine Platform Technologies and Mass Immunization Strategies174
The Role of Inflammation in Diabetic Retinopathy172
Regulation of PD-L1 Expression by NF-κB in Cancer172
Macrophages: The Good, the Bad, and the Gluttony171
SARS-CoV-2 Variants, Vaccines, and Host Immunity169
Macrophage Polarization and Its Role in Liver Disease169
TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease168
Aspects of the Tumor Microenvironment Involved in Immune Resistance and Drug Resistance166
Impact of Bacterial Metabolites on Gut Barrier Function and Host Immunity: A Focus on Bacterial Metabolism and Its Relevance for Intestinal Inflammation165
Severe COVID-19: NLRP3 Inflammasome Dysregulated164
Acute Transverse Myelitis (ATM):Clinical Review of 43 Patients With COVID-19-Associated ATM and 3 Post-Vaccination ATM Serious Adverse Events With the ChAdOx1 nCoV-19 Vaccine (AZD1222)163
The Role of PD-1 in Acute and Chronic Infection161
CD8+ T Cell Exhaustion in Cancer159
Remodeling of the Immune Response With Aging: Immunosenescence and Its Potential Impact on COVID-19 Immune Response158
Tumor-Infiltrating Lymphocytes and Their Prognostic Value in Cutaneous Melanoma158
Monocytes and Macrophages in COVID-19158
CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape157
The Role of Calcium–Calcineurin–NFAT Signaling Pathway in Health and Autoimmune Diseases156
T Cells in Fibrosis and Fibrotic Diseases156
Epstein-Barr Virus and Systemic Autoimmune Diseases154
Emerging Concepts and Technologies in Vaccine Development154
B and T Cells Driving Multiple Sclerosis: Identity, Mechanisms and Potential Triggers153
Molecular Heterogeneity and Immunosuppressive Microenvironment in Glioblastoma152
Role of Vascular Smooth Muscle Cell Plasticity and Interactions in Vessel Wall Inflammation150
Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity149
Phagocytosis of Apoptotic Cells in Resolution of Inflammation148
SARS-CoV-2 Vaccines Based on the Spike Glycoprotein and Implications of New Viral Variants147
Unraveling the Mystery Surrounding Post-Acute Sequelae of COVID-19146
Increased sCD163 and sCD14 Plasmatic Levels and Depletion of Peripheral Blood Pro-Inflammatory Monocytes, Myeloid and Plasmacytoid Dendritic Cells in Patients With Severe COVID-19 Pneumonia146
Metabolic Reprograming of Microglia in the Regulation of the Innate Inflammatory Response146
Identification of SARS-CoV-2 Cell Entry Inhibitors by Drug Repurposing Using in silico Structure-Based Virtual Screening Approach146
Neurotoxicity and Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy: Insights Into Mechanisms and Novel Therapies144
Intestinal Flora and Disease Mutually Shape the Regional Immune System in the Intestinal Tract143
NLRP3 Inflammasome Activation in Cancer: A Double-Edged Sword142
Phage Display Derived Monoclonal Antibodies: From Bench to Bedside141
NF-κB Pathway as a Potential Target for Treatment of Critical Stage COVID-19 Patients141
Adjuvants for Coronavirus Vaccines139
COVID-19: Coronavirus Vaccine Development Updates138
Role of the IL-23/IL-17 Pathway in Rheumatic Diseases: An Overview138
Different Innate and Adaptive Immune Responses to SARS-CoV-2 Infection of Asymptomatic, Mild, and Severe Cases138
Immunotherapy for Ovarian Cancer: Adjuvant, Combination, and Neoadjuvant138
Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response137
Anti-angiogenic Agents in Combination With Immune Checkpoint Inhibitors: A Promising Strategy for Cancer Treatment137
Novel Coronavirus-Induced NLRP3 Inflammasome Activation: A Potential Drug Target in the Treatment of COVID-19137
Efficacy, Immunogenicity and Safety of COVID-19 Vaccines: A Systematic Review and Meta-Analysis135
Exhausted CD8+T Cells in the Tumor Immune Microenvironment: New Pathways to Therapy135
The Chemokine Receptor CXCR4 in Cell Proliferation and Tissue Regeneration134
IL-1β and the Intestinal Epithelial Tight Junction Barrier134
The Global Epidemic of the SARS-CoV-2 Delta Variant, Key Spike Mutations and Immune Escape133
The Lung Macrophage in SARS-CoV-2 Infection: A Friend or a Foe?133
An Attempt to Polarize Human Neutrophils Toward N1 and N2 Phenotypes in vitro133
The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside132
Myeloid-Derived Suppressor Cells in Tumors: From Mechanisms to Antigen Specificity and Microenvironmental Regulation131
Genetics Insight for COVID-19 Susceptibility and Severity: A Review131
Probiotics in Medicine: A Long Debate131
Multiple Roles for Chemokines in Neutrophil Biology131
Microbiota Modulation of the Gut-Lung Axis in COVID-19131
Gamma-Delta CAR-T Cells Show CAR-Directed and Independent Activity Against Leukemia130
Reactive Oxygen Species in Macrophages: Sources and Targets130
Omicron: A Heavily Mutated SARS-CoV-2 Variant Exhibits Stronger Binding to ACE2 and Potently Escapes Approved COVID-19 Therapeutic Antibodies129
Overview: Systemic Inflammatory Response Derived From Lung Injury Caused by SARS-CoV-2 Infection Explains Severe Outcomes in COVID-19129
Versican—A Critical Extracellular Matrix Regulator of Immunity and Inflammation129
The Immune Response and Immunopathology of COVID-19128
Immune Cells in the BBB Disruption After Acute Ischemic Stroke: Targets for Immune Therapy?128
The Roles of Inflammation in Keloid and Hypertrophic Scars128
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