Frontiers in Pharmacology

Article	Citations
Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic	1128
Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications	422
Advances in Oral Drug Delivery	370
Perceptions of healthcare professionals and patients on the role of the pharmacist in TB management in Pakistan: A qualitative study	365
Dietary Polyphenols and Their Role in Oxidative Stress-Induced Human Diseases: Insights Into Protective Effects, Antioxidant Potentials and Mechanism(s) of Action	320
Herb and Spices in Colorectal Cancer Prevention and Treatment: A Narrative Review	313
Molecular Sets (MOSES): A Benchmarking Platform for Molecular Generation Models	306
Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors	305
Comparative effectiveness of individualized longer and standardized shorter regimens in the treatment of multidrug resistant tuberculosis in a high burden country	301
PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease	208
DNA Repair Pathways in Cancer Therapy and Resistance	196
Activation of PI3K/AKT/mTOR Pathway Causes Drug Resistance in Breast Cancer	189
COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?	181
Uric Acid and Cardiovascular Disease: An Update From Molecular Mechanism to Clinical Perspective	178
PD-1/PD-L1 Checkpoint Inhibitors in Tumor Immunotherapy	177
PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy	165
Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence	162
The Role of the CXCL12/CXCR4/CXCR7 Chemokine Axis in Cancer	160
Comprehensive Analysis of Cuproptosis-Related Genes in Immune Infiltration and Prognosis in Melanoma	159
Overview of OxLDL and Its Impact on Cardiovascular Health: Focus on Atherosclerosis	158
Phytosterols: From Preclinical Evidence to Potential Clinical Applications	155
The Evasion Mechanisms of Cancer Immunity and Drug Intervention in the Tumor Microenvironment	152
Non-Alcoholic Steatohepatitis: A Review of Its Mechanism, Models and Medical Treatments	140
Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review	139
Fluvoxamine: A Review of Its Mechanism of Action and Its Role in COVID-19	137

AKT Inhibitors: New Weapons in the Fight Against Breast Cancer?	137
Response to the Novel Corona Virus (COVID-19) Pandemic Across Africa: Successes, Challenges, and Implications for the Future	134
A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective	133
Clinically-Relevant ABC Transporter for Anti-Cancer Drug Resistance	127
A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin	126
Neurodegenerative Disease and the NLRP3 Inflammasome	122
Remimazolam: Non-Clinical and Clinical Profile of a New Sedative/Anesthetic Agent	120
Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research	119
The Pharmacological Action of Kaempferol in Central Nervous System Diseases: A Review	119
Research progress of glutathione peroxidase family (GPX) in redoxidation	118
Mesenchymal Stem Cell–Derived Exosomes: A Promising Biological Tool in Nanomedicine	116
Oral Curcumin With Piperine as Adjuvant Therapy for the Treatment of COVID-19: A Randomized Clinical Trial	116
Baicalin Prevents Myocardial Ischemia/Reperfusion Injury Through Inhibiting ACSL4 Mediated Ferroptosis	113
Drug Shortage: Causes, Impact, and Mitigation Strategies	112
Heavy Metal Contaminations in Herbal Medicines: Determination, Comprehensive Risk Assessments, and Solutions	111
G Protein-Coupled Receptors in Taste Physiology and Pharmacology	111
Cellular Mechanisms of Liver Fibrosis	111
Exploring Phytochemicals for Combating Antibiotic Resistance in Microbial Pathogens	107
Novel and Emerging Therapies for Inflammatory Bowel Disease	106
Genistein: A Review on its Anti-Inflammatory Properties	105
Advanced Approaches to Breast Cancer Classification and Diagnosis	105
Anti-SARS-CoV Natural Products With the Potential to Inhibit SARS-CoV-2 (COVID-19)	105
The Role of Oxidative Stress and Natural Antioxidants in Ovarian Aging	105
Idiopathic Pulmonary Fibrosis: An Update on Pathogenesis	104
The Drug Repurposing for COVID-19 Clinical Trials Provide Very Effective Therapeutic Combinations: Lessons Learned From Major Clinical Studies	104
Pharmacogenetics Guidelines: Overview and Comparison of the DPWG, CPIC, CPNDS, and RNPGx Guidelines	103
Current Prevention of COVID-19: Natural Products and Herbal Medicine	101
Challenges for Drug Repurposing in the COVID-19 Pandemic Era	101
Targeting the Integrated Stress Response in Cancer Therapy	100
Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer's Disease	100
Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application	98
Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits	97
Polyphenols as Antitumor Agents Targeting Key Players in Cancer-Driving Signaling Pathways	96
Natural Compounds With Antimicrobial and Antiviral Effect and Nanocarriers Used for Their Transportation	95
SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases	95
The Role of Tumor Inflammatory Microenvironment in Lung Cancer	93
Functions and Diseases of the Retinal Pigment Epithelium	92
Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators—What is the Evidence so far?	92
Neuropharmacological Effects of Quercetin: A Literature-Based Review	90
System Xc−/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy	90
Best Practice in the chemical characterisation of extracts used in pharmacological and toxicological research—The ConPhyMP—Guidelines12	89
Progress in the Understanding of the Mechanism of Tamoxifen Resistance in Breast Cancer	89
FDX1 can Impact the Prognosis and Mediate the Metabolism of Lung Adenocarcinoma	87
Analgesic Effect of Acetaminophen: A Review of Known and Novel Mechanisms of Action	87
Trends in Antidiabetic Drug Discovery: FDA Approved Drugs, New Drugs in Clinical Trials and Global Sales	86
Psychedelic Communitas: Intersubjective Experience During Psychedelic Group Sessions Predicts Enduring Changes in Psychological Wellbeing and Social Connectedness	86
Pharmacological Effects of Salvianolic Acid B Against Oxidative Damage	86
Mechanisms of Chemotherapy-Induced Neurotoxicity	85
Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease	84
Targeting Neutrophils to Treat Acute Respiratory Distress Syndrome in Coronavirus Disease	84

Curcumin as a Potential Treatment for COVID-19	83
Clinical Review: Navitoclax as a Pro-Apoptotic and Anti-Fibrotic Agent	82
Eicosanoids in Cancer: New Roles in Immunoregulation	81
Oxidative Stress and Hyper-Inflammation as Major Drivers of Severe COVID-19 and Long COVID: Implications for the Benefit of High-Dose Intravenous Vitamin C	81
Understanding the role of the gut microbiome in gastrointestinal cancer: A review	80
Baicalin Inhibits Ferroptosis in Intracerebral Hemorrhage	80
Clinical Insights Into Novel Immune Checkpoint Inhibitors	80
Post-treatment With Irisin Attenuates Acute Kidney Injury in Sepsis Mice Through Anti-Ferroptosis via the SIRT1/Nrf2 Pathway	79
Insight Into the Prospects for RNAi Therapy of Cancer	79
Fisetin Attenuates Doxorubicin-Induced Cardiomyopathy In Vivo and In Vitro by Inhibiting Ferroptosis Through SIRT1/Nrf2 Signaling Pathway Activation	79
New Insights Into Gut-Bacteria-Derived Indole and Its Derivatives in Intestinal and Liver Diseases	78
The Inhibitory Effect of 6-Gingerol on Ubiquitin-Specific Peptidase 14 Enhances Autophagy-Dependent Ferroptosis and Anti-Tumor in vivo and in vitro	77
Chlorogenic Acid Improves NAFLD by Regulating gut Microbiota and GLP-1	77
Fecal Microbiota Transplantation for the Treatment of Inflammatory Bowel Disease: An Update	76
Dysfunctional Vascular Endothelium as a Driver of Atherosclerosis: Emerging Insights Into Pathogenesis and Treatment	76
Transforming Growth Factor-Beta (TGF-β) Signaling in Cancer-A Betrayal Within	76
A Review of the Pharmacological Properties of Psoralen	75
Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway	75
JAK/STAT Signaling: Molecular Targets, Therapeutic Opportunities, and Limitations of Targeted Inhibitions in Solid Malignancies	74
Analysis of Models of Doxorubicin-Induced Cardiomyopathy in Rats and Mice. A Modern View From the Perspective of the Pathophysiologist and the Clinician	74
Pyroptosis in the Initiation and Progression of Atherosclerosis	74
Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies	72
Therapeutic Alliance and Rapport Modulate Responses to Psilocybin Assisted Therapy for Depression	72
α1-Adrenergic Receptors in Neurotransmission, Synaptic Plasticity, and Cognition	72
Case Report: Central Retinal Artery Occlusion in a COVID-19 Patient	71
Repurposing Sigma-1 Receptor Ligands for COVID-19 Therapy?	71
The Biological Functions and Clinical Applications of Integrins in Cancers	71
Glucosinolates From Cruciferous Vegetables and Their Potential Role in Chronic Disease: Investigating the Preclinical and Clinical Evidence	71
Metformin: A Novel Weapon Against Inflammation	70
Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives	70
Interleukin-6: A Novel Target for Cardio-Cerebrovascular Diseases	70
Safety and Efficacy of Bromodomain and Extra-Terminal Inhibitors for the Treatment of Hematological Malignancies and Solid Tumors: A Systematic Study of Clinical Trials	70
The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions	70
Calming the Storm: Natural Immunosuppressants as Adjuvants to Target the Cytokine Storm in COVID-19	69
Possible Benefits of Faecalibacterium prausnitzii for Obesity-Associated Gut Disorders	69
Lactoferrin Against SARS-CoV-2: In Vitro and In Silico Evidences	69
A Comprehensive Account on Recent Progress in Pharmacological Activities of Benzimidazole Derivatives	69
The Role of Interleukin-8 in Lung Inflammation and Injury: Implications for the Management of COVID-19 and Hyperinflammatory Acute Respiratory Distress Syndrome	68
MicroRNA as an Important Target for Anticancer Drug Development	68
Gut microbiome and human health: Exploring how the probiotic genus Lactobacillus modulate immune responses	68
Cannabidiol as a Therapeutic Target: Evidence of its Neuroprotective and Neuromodulatory Function in Parkinson’s Disease	68
Postoperative Ileus and Postoperative Gastrointestinal Tract Dysfunction: Pathogenic Mechanisms and Novel Treatment Strategies Beyond Colorectal Enhanced Recovery After Surgery Protocols	67
Minor Cannabinoids: Biosynthesis, Molecular Pharmacology and Potential Therapeutic Uses	67
Traditional Herbal Medicines, Bioactive Metabolites, and Plant Products Against COVID-19: Update on Clinical Trials and Mechanism of Actions	67
An Update on Antiviral Therapy Against SARS-CoV-2: How Far Have We Come?	66
The Role of NLRP3 Inflammasome in Alzheimer’s Disease and Potential Therapeutic Targets	65
Tanshinone IIA: A Review of its Anticancer Effects	65
Formulation and Development of Transferrin Targeted Solid Lipid Nanoparticles for Breast Cancer Therapy	64
Phytochemistry and Pharmacological Activities of Wolfiporia cocos (F.A. Wolf) Ryvarden & Gilb	64
Machine Learning Techniques for Personalised Medicine Approaches in Immune-Mediated Chronic Inflammatory Diseases: Applications and Challenges	64
Improvement of Gold Nanorods in Photothermal Therapy: Recent Progress and Perspective	64
Platinum Nanoparticles in Biomedicine: Preparation, Anti-Cancer Activity, and Drug Delivery Vehicles	64
Gastroprotective Effect of Sinapic Acid on Ethanol-Induced Gastric Ulcers in Rats: Involvement of Nrf2/HO-1 and NF-κB Signaling and Antiapoptotic Role	64
Gastrin Attenuates Renal Ischemia/Reperfusion Injury by a PI3K/Akt/Bad-Mediated Anti-apoptosis Signaling	64
The Advancing of Selenium Nanoparticles Against Infectious Diseases	64
1,2,3-Triazole-Containing Compounds as Anti–Lung Cancer Agents: Current Developments, Mechanisms of Action, and Structure–Activity Relationship	63
Cordyceps spp.: A Review on Its Immune-Stimulatory and Other Biological Potentials	63
Myricetin Inhibits SARS-CoV-2 Viral Replication by Targeting Mpro and Ameliorates Pulmonary Inflammation	63
Necroptosis: A Novel Pathway in Neuroinflammation	62
A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine	62
Multi-Target Approaches in Metabolic Syndrome	62
Efficacy and Safety of Sophora flavescens (Kushen) Based Traditional Chinese Medicine in the Treatment of Ulcerative Colitis: Clinical Evidence and Potential Mechanisms	62
Crosstalk Between Dysfunctional Mitochondria and Inflammation in Glaucomatous Neurodegeneration	62
A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies	62
Bibliometric Analysis of Global Research on Cancer Photodynamic Therapy: Focus on Nano-Related Research	62
Multi-Omics Analysis of Microglial Extracellular Vesicles From Human Alzheimer’s Disease Brain Tissue Reveals Disease-Associated Signatures	61
Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2	61
Methylene Blue Inhibits the SARS-CoV-2 Spike–ACE2 Protein-Protein Interaction–a Mechanism that can Contribute to its Antiviral Activity Against COVID-19	61
Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway	61
Heterocyclic Compounds: Pharmacology of Pyrazole Analogs From Rational Structural Considerations	61
New Trends in Pharmacological Treatments for Osteoarthritis	60
Natural Anti-Inflammatory Compounds as Drug Candidates for Inflammatory Bowel Disease	60
Medicinal Prospects of Antioxidants From Algal Sources in Cancer Therapy	59
Formononetin Attenuates Airway Inflammation and Oxidative Stress in Murine Allergic Asthma	59
Pharmacological Activities and Mechanisms of Hirudin and Its Derivatives - A Review	59
Withania somnifera (L.) Dunal: Opportunity for Clinical Repurposing in COVID-19 Management	59
Diallyl Disulfide: A Bioactive Garlic Compound with Anticancer Potential	59
Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral Cancer	59
Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip	59
Innate Immunity in Diabetic Wound Healing: Focus on the Mastermind Hidden in Chronic Inflammatory	59

Phytochemistry, Pharmacology and Medicinal Uses of Plants of the Genus Salix: An Updated Review	58
The Potential of Antiviral Peptides as COVID-19 Therapeutics	58
Sodium–Glucose CoTransporter-2 Inhibitor Empagliflozin Ameliorates Sunitinib-Induced Cardiac Dysfunction via Regulation of AMPK–mTOR Signaling Pathway–Mediated Autophagy	58
The Role of Photoactivated and Non-Photoactivated Verteporfin on Tumor	58
Inflammatory Bowel Disease and Risk of Colorectal Cancer: An Overview From Pathophysiology to Pharmacological Prevention	58
Therapeutic Effects of Naringin in Rheumatoid Arthritis: Network Pharmacology and Experimental Validation	58
Natural Compounds as Medical Strategies in the Prevention and Treatment of Psychiatric Disorders Seen in Neurological Diseases	57
CD44-Targeted Nanocarrier for Cancer Therapy	57
Monoamine Oxidase Inhibitors: A Review of Their Anti-Inflammatory Therapeutic Potential and Mechanisms of Action	57
Medicinal Plants in COVID-19: Potential and Limitations	57
Single-Target Versus Multi-Target Drugs Versus Combinations of Drugs With Multiple Targets: Preclinical and Clinical Evidence for the Treatment or Prevention of Epilepsy	56
Does Oral Apigenin Have Real Potential for a Therapeutic Effect in the Context of Human Gastrointestinal and Other Cancers?	56
A Review of Approaches for Predicting Drug–Drug Interactions Based on Machine Learning	56
Role of Butyrate, a Gut Microbiota Derived Metabolite, in Cardiovascular Diseases: A comprehensive narrative review	56
Phagocytosis, Degranulation and Extracellular Traps Release by Neutrophils—The Current Knowledge, Pharmacological Modulation and Future Prospects	55
Salidroside Attenuates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice and Modulates Inflammation of the Gut-Brain Axis	55
Antitumor Effects of Carvacrol and Thymol: A Systematic Review	55
Effectiveness and Safety of Oral Anticoagulants in Older Patients With Atrial Fibrillation: A Systematic Review and Meta-Analysis	55
SARS-CoV-2 Switches ‘on’ MAPK and NFκB Signaling via the Reduction of Nuclear DUSP1 and DUSP5 Expression	55
Metabolic Profile, Bioactivities, and Variations in the Chemical Constituents of Essential Oils of the Ferula Genus (Apiaceae)	55
Potential Natural Products Against Respiratory Viruses: A Perspective to Develop Anti-COVID-19 Medicines	55
Linker Design Impacts Antibody-Drug Conjugate Pharmacokinetics and Efficacy via Modulating the Stability and Payload Release Efficiency	54
Receptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer	54
Interleukins 4 and 13 in Asthma: Key Pathophysiologic Cytokines and Druggable Molecular Targets	54
Bilirubin Nanoparticles Reduce Diet-Induced Hepatic Steatosis, Improve Fat Utilization, and Increase Plasma β-Hydroxybutyrate	54
Natural Product Erianin Inhibits Bladder Cancer Cell Growth by Inducing Ferroptosis via NRF2 Inactivation	54
Total Flavones of Abelmoschus manihot Ameliorates Podocyte Pyroptosis and Injury in High Glucose Conditions by Targeting METTL3-Dependent m6A Modification-Mediated NLRP3-Inflammasome Activation and PT	54
Glomerular Endothelial Cells as Instigators of Glomerular Sclerotic Diseases	54
Bibliometric Analysis of Global Research Trends on Ultrasound Microbubble: A Quickly Developing Field	54
Bibliometric Analysis of the Inflammasome and Pyroptosis in Brain	54
First-Line Immune-Checkpoint Inhibitors in Non-Small Cell Lung Cancer: Current Landscape and Future Progress	53
Diabetic Nephropathy: Novel Molecular Mechanisms and Therapeutic Targets	53
Novel Methods and Approaches for Safety Evaluation of Nanoparticle Formulations: A Focus Towards In Vitro Models and Adverse Outcome Pathways	53
Review of Shikonin and Derivatives: Isolation, Chemistry, Biosynthesis, Pharmacology and Toxicology	53
Inulin Exerts Beneficial Effects on Non-Alcoholic Fatty Liver Disease via Modulating gut Microbiome and Suppressing the Lipopolysaccharide-Toll-Like Receptor 4-Mψ-Nuclear Factor-κB-Nod-Like Receptor P	53
Lidocaine Promoted Ferroptosis by Targeting miR-382-5p /SLC7A11 Axis in Ovarian and Breast Cancer	52
Pharmacogenetics in Psychiatry: An Update on Clinical Usability	52
Knowledge Domain and Emerging Trends in Podocyte Injury Research From 1994 to 2021: A Bibliometric and Visualized Analysis	52
Favipiravir Versus Arbidol for Clinical Recovery Rate in Moderate and Severe Adult COVID-19 Patients: A Prospective, Multicenter, Open-Label, Randomized Controlled Clinical Trial	52
Pharmacokinetics and Excretion of Berberine and Its Nine Metabolites in Rats	52
Nano and Microparticles as Potential Oral Vaccine Carriers and Adjuvants Against Infectious Diseases	52
Mitochondrial Iron Overload-Mediated Inhibition of Nrf2-HO-1/GPX4 Assisted ALI-Induced Nephrotoxicity	52
Maresin1 Protect Against Ferroptosis-Induced Liver Injury Through ROS Inhibition and Nrf2/HO-1/GPX4 Activation	52
Fisetin Rescues the Mice Brains Against D-Galactose-Induced Oxidative Stress, Neuroinflammation and Memory Impairment	52
Current State and Future Directions of Intranasal Delivery Route for Central Nervous System Disorders: A Scientometric and Visualization Analysis	51
Taohong Siwu Decoction Ameliorates Ischemic Stroke Injury Via Suppressing Pyroptosis	51
Targeting the Wnt/β-Catenin Signaling Pathway as a Potential Therapeutic Strategy in Renal Tubulointerstitial Fibrosis	51
New Developments in Prokinetic Therapy for Gastric Motility Disorders	51
Therapeutic Applications of Terpenes on Inflammatory Diseases	51
Pharmacological Activities of Psoralidin: A Comprehensive Review of the Molecular Mechanisms of Action	51
Dapagliflozin Alleviates Hepatic Steatosis by Restoring Autophagy via the AMPK-mTOR Pathway	51
COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms	51
Dexmedetomidine Attenuates Ferroptosis-Mediated Renal Ischemia/Reperfusion Injury and Inflammation by Inhibiting ACSL4 via α2-AR	51
Emerging Role of MiR-192-5p in Human Diseases	50
Targeting Angiogenesis in Breast Cancer: Current Evidence and Future Perspectives of Novel Anti-Angiogenic Approaches	50
Galangin Inhibits Gastric Cancer Growth Through Enhancing STAT3 Mediated ROS Production	50
Regulatory Mechanisms of Baicalin in Cardiovascular Diseases: A Review	50
A Review on Plant Bioactive Compounds and Their Modes of Action Against Coronavirus Infection	50
Analysis of Antidepressant Activity of Huang-Lian Jie-Du Decoction Through Network Pharmacology and Metabolomics	50
The Antimicrobial Potential of the Neem Tree Azadirachta indica	50
Significance of Medicinal Mushrooms in Integrative Oncology: A Narrative Review	50
Antibiotic Combination Therapy: A Strategy to Overcome Bacterial Resistance to Aminoglycoside Antibiotics	50
Inflammatory Caspases Drive Pyroptosis in Acute Lung Injury	50
Ferulic Acid Ameliorates Atherosclerotic Injury by Modulating Gut Microbiota and Lipid Metabolism	50
Efficacy and Safety of Berberine Alone for Several Metabolic Disorders: A Systematic Review and Meta-Analysis of Randomized Clinical Trials	49
Targeting Oxidative Stress as a Therapeutic Approach for Idiopathic Pulmonary Fibrosis	49
TLR9 and COVID-19: A Multidisciplinary Theory of a Multifaceted Therapeutic Target	49
The Role of Uptake and Efflux Transporters in the Disposition of Glucuronide and Sulfate Conjugates	49
Review of various NAMPT inhibitors for the treatment of cancer	49
Targeting Neutrophils in Sepsis: From Mechanism to Translation	49
Ginger from Farmyard to Town: Nutritional and Pharmacological Applications	49
A Review of Medicinal Plants with Antiviral Activity Available in Bangladesh and Mechanistic Insight Into Their Bioactive Metabolites on SARS-CoV-2, HIV and HBV	48
Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRS	48
RIPK2 as a New Therapeutic Target in Inflammatory Bowel Diseases	48
Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies	48
The efficacy and safety of JAK inhibitors for alopecia areata: A systematic review and meta-analysis of prospective studies	48
The Breast Cancer Stem Cells Traits and Drug Resistance	48
The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress	48
Effects of Puerarin on the Prevention and Treatment of Cardiovascular Diseases	47
Immunomodulatory Effects and Mechanisms of Curcuma Species and Their Bioactive Compounds: A Review	47
Anticancer Applications and Pharmacological Properties of Piperidine and Piperine: A Comprehensive Review on Molecular Mechanisms and Therapeutic Perspectives	47
Berberine: A Review of its Pharmacokinetics Properties and Therapeutic Potentials in Diverse Vascular Diseases	47
Insights Into Amentoflavone: A Natural Multifunctional Biflavonoid	47
Maresin 1 Attenuates Lipopolysaccharide-Induced Acute Kidney Injury via Inhibiting NOX4/ROS/NF-κB Pathway	47
A Review of Treatment of Coronavirus Disease 2019 (COVID-19): Therapeutic Repurposing and Unmet Clinical Needs	47
Ketamine Use for Cancer and Chronic Pain Management	47
Roles of Macrophages in Atherogenesis	46
Shenkang Injection and Its Three Anthraquinones Ameliorates Renal Fibrosis by Simultaneous Targeting IƙB/NF-ƙB and Keap1/Nrf2 Signaling Pathways	46
Andrade-Oliveira Salvianolic Acid B Modulates Caspase-1–Mediated Pyroptosis in Renal Ischemia-Reperfusion Injury via Nrf2 Pathway	46
Anti–SARS-CoV-2 Natural Products as Potentially Therapeutic Agents	46
Active Components and Pharmacological Effects of Cornus officinalis: Literature Review	46
Pulmonary Edema in COVID-19 Patients: Mechanisms and Treatment Potential	46
The Potential of Chitosan in Nanomedicine: An Overview of the Cytotoxicity of Chitosan Based Nanoparticles	46
Targeting Neuroinflammation in Brain Cancer: Uncovering Mechanisms, Pharmacological Targets, and Neuropharmaceutical Developments	46
Essential Oils as Multicomponent Mixtures and Their Potential for Human Health and Well-Being	46