Frontiers in Pharmacology

Article	Citations
Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic	1176
Advances in Oral Drug Delivery	384
Perceptions of healthcare professionals and patients on the role of the pharmacist in TB management in Pakistan: A qualitative study	365
Dietary Polyphenols and Their Role in Oxidative Stress-Induced Human Diseases: Insights Into Protective Effects, Antioxidant Potentials and Mechanism(s) of Action	345
Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors	317
Molecular Sets (MOSES): A Benchmarking Platform for Molecular Generation Models	316
Herb and Spices in Colorectal Cancer Prevention and Treatment: A Narrative Review	314
Comparative effectiveness of individualized longer and standardized shorter regimens in the treatment of multidrug resistant tuberculosis in a high burden country	301
PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease	215
DNA Repair Pathways in Cancer Therapy and Resistance	199
Activation of PI3K/AKT/mTOR Pathway Causes Drug Resistance in Breast Cancer	192
Uric Acid and Cardiovascular Disease: An Update From Molecular Mechanism to Clinical Perspective	186
PD-1/PD-L1 Checkpoint Inhibitors in Tumor Immunotherapy	182
Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence	166
PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy	166
The Role of the CXCL12/CXCR4/CXCR7 Chemokine Axis in Cancer	163
Comprehensive Analysis of Cuproptosis-Related Genes in Immune Infiltration and Prognosis in Melanoma	160
Overview of OxLDL and Its Impact on Cardiovascular Health: Focus on Atherosclerosis	160
Phytosterols: From Preclinical Evidence to Potential Clinical Applications	159
The Evasion Mechanisms of Cancer Immunity and Drug Intervention in the Tumor Microenvironment	154
Non-Alcoholic Steatohepatitis: A Review of Its Mechanism, Models and Medical Treatments	141
AKT Inhibitors: New Weapons in the Fight Against Breast Cancer?	138
Fluvoxamine: A Review of Its Mechanism of Action and Its Role in COVID-19	137
A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective	136
Research progress of glutathione peroxidase family (GPX) in redoxidation	132

Clinically-Relevant ABC Transporter for Anti-Cancer Drug Resistance	128
A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin	128
Neurodegenerative Disease and the NLRP3 Inflammasome	122
Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research	121
The Pharmacological Action of Kaempferol in Central Nervous System Diseases: A Review	121
Remimazolam: Non-Clinical and Clinical Profile of a New Sedative/Anesthetic Agent	121
Oral Curcumin With Piperine as Adjuvant Therapy for the Treatment of COVID-19: A Randomized Clinical Trial	120
Heavy Metal Contaminations in Herbal Medicines: Determination, Comprehensive Risk Assessments, and Solutions	117
Mesenchymal Stem Cell–Derived Exosomes: A Promising Biological Tool in Nanomedicine	117
Drug Shortage: Causes, Impact, and Mitigation Strategies	116
G Protein-Coupled Receptors in Taste Physiology and Pharmacology	115
Baicalin Prevents Myocardial Ischemia/Reperfusion Injury Through Inhibiting ACSL4 Mediated Ferroptosis	113
Cellular Mechanisms of Liver Fibrosis	112
Novel and Emerging Therapies for Inflammatory Bowel Disease	110
Exploring Phytochemicals for Combating Antibiotic Resistance in Microbial Pathogens	110
Idiopathic Pulmonary Fibrosis: An Update on Pathogenesis	108
Advanced Approaches to Breast Cancer Classification and Diagnosis	106
The Drug Repurposing for COVID-19 Clinical Trials Provide Very Effective Therapeutic Combinations: Lessons Learned From Major Clinical Studies	106
The Role of Oxidative Stress and Natural Antioxidants in Ovarian Aging	106
Genistein: A Review on its Anti-Inflammatory Properties	106
Pharmacogenetics Guidelines: Overview and Comparison of the DPWG, CPIC, CPNDS, and RNPGx Guidelines	103
Challenges for Drug Repurposing in the COVID-19 Pandemic Era	102
Targeting the Integrated Stress Response in Cancer Therapy	101
Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer's Disease	101
Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application	100
Polyphenols as Antitumor Agents Targeting Key Players in Cancer-Driving Signaling Pathways	98
Natural Compounds With Antimicrobial and Antiviral Effect and Nanocarriers Used for Their Transportation	98
Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits	98
The Role of Tumor Inflammatory Microenvironment in Lung Cancer	96
SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases	96
Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators—What is the Evidence so far?	96
Neuropharmacological Effects of Quercetin: A Literature-Based Review	92
Functions and Diseases of the Retinal Pigment Epithelium	92
System Xc−/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy	92
Progress in the Understanding of the Mechanism of Tamoxifen Resistance in Breast Cancer	92
Best Practice in the chemical characterisation of extracts used in pharmacological and toxicological research—The ConPhyMP—Guidelines12	91
FDX1 can Impact the Prognosis and Mediate the Metabolism of Lung Adenocarcinoma	90
Trends in Antidiabetic Drug Discovery: FDA Approved Drugs, New Drugs in Clinical Trials and Global Sales	89
Psychedelic Communitas: Intersubjective Experience During Psychedelic Group Sessions Predicts Enduring Changes in Psychological Wellbeing and Social Connectedness	89
Analgesic Effect of Acetaminophen: A Review of Known and Novel Mechanisms of Action	87
Pharmacological Effects of Salvianolic Acid B Against Oxidative Damage	86
Mechanisms of Chemotherapy-Induced Neurotoxicity	86
Curcumin as a Potential Treatment for COVID-19	85
Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease	85
Fisetin Attenuates Doxorubicin-Induced Cardiomyopathy In Vivo and In Vitro by Inhibiting Ferroptosis Through SIRT1/Nrf2 Signaling Pathway Activation	84
Oxidative Stress and Hyper-Inflammation as Major Drivers of Severe COVID-19 and Long COVID: Implications for the Benefit of High-Dose Intravenous Vitamin C	83
Baicalin Inhibits Ferroptosis in Intracerebral Hemorrhage	83
Clinical Review: Navitoclax as a Pro-Apoptotic and Anti-Fibrotic Agent	83
Understanding the role of the gut microbiome in gastrointestinal cancer: A review	82
Post-treatment With Irisin Attenuates Acute Kidney Injury in Sepsis Mice Through Anti-Ferroptosis via the SIRT1/Nrf2 Pathway	82

New Insights Into Gut-Bacteria-Derived Indole and Its Derivatives in Intestinal and Liver Diseases	81
Eicosanoids in Cancer: New Roles in Immunoregulation	81
Insight Into the Prospects for RNAi Therapy of Cancer	80
Clinical Insights Into Novel Immune Checkpoint Inhibitors	80
Transforming Growth Factor-Beta (TGF-β) Signaling in Cancer-A Betrayal Within	79
The Inhibitory Effect of 6-Gingerol on Ubiquitin-Specific Peptidase 14 Enhances Autophagy-Dependent Ferroptosis and Anti-Tumor in vivo and in vitro	78
Dysfunctional Vascular Endothelium as a Driver of Atherosclerosis: Emerging Insights Into Pathogenesis and Treatment	78
Therapeutic Alliance and Rapport Modulate Responses to Psilocybin Assisted Therapy for Depression	78
Chlorogenic Acid Improves NAFLD by Regulating gut Microbiota and GLP-1	77
JAK/STAT Signaling: Molecular Targets, Therapeutic Opportunities, and Limitations of Targeted Inhibitions in Solid Malignancies	77
Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway	77
Analysis of Models of Doxorubicin-Induced Cardiomyopathy in Rats and Mice. A Modern View From the Perspective of the Pathophysiologist and the Clinician	76
Pyroptosis in the Initiation and Progression of Atherosclerosis	74
Interleukin-6: A Novel Target for Cardio-Cerebrovascular Diseases	74
Case Report: Central Retinal Artery Occlusion in a COVID-19 Patient	73
Glucosinolates From Cruciferous Vegetables and Their Potential Role in Chronic Disease: Investigating the Preclinical and Clinical Evidence	73
Gut microbiome and human health: Exploring how the probiotic genus Lactobacillus modulate immune responses	72
Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies	72
Repurposing Sigma-1 Receptor Ligands for COVID-19 Therapy?	72
The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions	71
Metformin: A Novel Weapon Against Inflammation	71
Minor Cannabinoids: Biosynthesis, Molecular Pharmacology and Potential Therapeutic Uses	70
Safety and Efficacy of Bromodomain and Extra-Terminal Inhibitors for the Treatment of Hematological Malignancies and Solid Tumors: A Systematic Study of Clinical Trials	70
Lactoferrin Against SARS-CoV-2: In Vitro and In Silico Evidences	70
A Comprehensive Account on Recent Progress in Pharmacological Activities of Benzimidazole Derivatives	70
The Role of Interleukin-8 in Lung Inflammation and Injury: Implications for the Management of COVID-19 and Hyperinflammatory Acute Respiratory Distress Syndrome	69
Possible Benefits of Faecalibacterium prausnitzii for Obesity-Associated Gut Disorders	69
Calming the Storm: Natural Immunosuppressants as Adjuvants to Target the Cytokine Storm in COVID-19	69
MicroRNA as an Important Target for Anticancer Drug Development	68
Cannabidiol as a Therapeutic Target: Evidence of its Neuroprotective and Neuromodulatory Function in Parkinson’s Disease	68
Postoperative Ileus and Postoperative Gastrointestinal Tract Dysfunction: Pathogenic Mechanisms and Novel Treatment Strategies Beyond Colorectal Enhanced Recovery After Surgery Protocols	68
Traditional Herbal Medicines, Bioactive Metabolites, and Plant Products Against COVID-19: Update on Clinical Trials and Mechanism of Actions	67
An Update on Antiviral Therapy Against SARS-CoV-2: How Far Have We Come?	66
The Advancing of Selenium Nanoparticles Against Infectious Diseases	66
Improvement of Gold Nanorods in Photothermal Therapy: Recent Progress and Perspective	66
Machine Learning Techniques for Personalised Medicine Approaches in Immune-Mediated Chronic Inflammatory Diseases: Applications and Challenges	66
Tanshinone IIA: A Review of its Anticancer Effects	66
Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway	66
Gastroprotective Effect of Sinapic Acid on Ethanol-Induced Gastric Ulcers in Rats: Involvement of Nrf2/HO-1 and NF-κB Signaling and Antiapoptotic Role	65
Gastrin Attenuates Renal Ischemia/Reperfusion Injury by a PI3K/Akt/Bad-Mediated Anti-apoptosis Signaling	65
The Role of NLRP3 Inflammasome in Alzheimer’s Disease and Potential Therapeutic Targets	65
Platinum Nanoparticles in Biomedicine: Preparation, Anti-Cancer Activity, and Drug Delivery Vehicles	65
Cordyceps spp.: A Review on Its Immune-Stimulatory and Other Biological Potentials	64
Formulation and Development of Transferrin Targeted Solid Lipid Nanoparticles for Breast Cancer Therapy	64
Necroptosis: A Novel Pathway in Neuroinflammation	63
Efficacy and Safety of Sophora flavescens (Kushen) Based Traditional Chinese Medicine in the Treatment of Ulcerative Colitis: Clinical Evidence and Potential Mechanisms	63
1,2,3-Triazole-Containing Compounds as Anti–Lung Cancer Agents: Current Developments, Mechanisms of Action, and Structure–Activity Relationship	63
Myricetin Inhibits SARS-CoV-2 Viral Replication by Targeting Mpro and Ameliorates Pulmonary Inflammation	63
Crosstalk Between Dysfunctional Mitochondria and Inflammation in Glaucomatous Neurodegeneration	63
Multi-Omics Analysis of Microglial Extracellular Vesicles From Human Alzheimer’s Disease Brain Tissue Reveals Disease-Associated Signatures	62
Multi-Target Approaches in Metabolic Syndrome	62
Bibliometric Analysis of Global Research on Cancer Photodynamic Therapy: Focus on Nano-Related Research	62
Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral Cancer	62
A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies	62
Innate Immunity in Diabetic Wound Healing: Focus on the Mastermind Hidden in Chronic Inflammatory	62
Inflammatory Bowel Disease and Risk of Colorectal Cancer: An Overview From Pathophysiology to Pharmacological Prevention	62
Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2	62
New Trends in Pharmacological Treatments for Osteoarthritis	62
Natural Anti-Inflammatory Compounds as Drug Candidates for Inflammatory Bowel Disease	62
Heterocyclic Compounds: Pharmacology of Pyrazole Analogs From Rational Structural Considerations	61
Pharmacological Activities and Mechanisms of Hirudin and Its Derivatives - A Review	61
Phytochemistry, Pharmacology and Medicinal Uses of Plants of the Genus Salix: An Updated Review	61
Methylene Blue Inhibits the SARS-CoV-2 Spike–ACE2 Protein-Protein Interaction–a Mechanism that can Contribute to its Antiviral Activity Against COVID-19	61
Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip	60
Sodium–Glucose CoTransporter-2 Inhibitor Empagliflozin Ameliorates Sunitinib-Induced Cardiac Dysfunction via Regulation of AMPK–mTOR Signaling Pathway–Mediated Autophagy	59
Monoamine Oxidase Inhibitors: A Review of Their Anti-Inflammatory Therapeutic Potential and Mechanisms of Action	59
Medicinal Prospects of Antioxidants From Algal Sources in Cancer Therapy	59
Withania somnifera (L.) Dunal: Opportunity for Clinical Repurposing in COVID-19 Management	59
Bibliometric Analysis of Global Research Trends on Ultrasound Microbubble: A Quickly Developing Field	59
Diallyl Disulfide: A Bioactive Garlic Compound with Anticancer Potential	59
Single-Target Versus Multi-Target Drugs Versus Combinations of Drugs With Multiple Targets: Preclinical and Clinical Evidence for the Treatment or Prevention of Epilepsy	58
CD44-Targeted Nanocarrier for Cancer Therapy	58
Natural Compounds as Medical Strategies in the Prevention and Treatment of Psychiatric Disorders Seen in Neurological Diseases	58
SARS-CoV-2 Switches ‘on’ MAPK and NFκB Signaling via the Reduction of Nuclear DUSP1 and DUSP5 Expression	58
A Review of Approaches for Predicting Drug–Drug Interactions Based on Machine Learning	58
Therapeutic Effects of Naringin in Rheumatoid Arthritis: Network Pharmacology and Experimental Validation	58
Medicinal Plants in COVID-19: Potential and Limitations	57
Does Oral Apigenin Have Real Potential for a Therapeutic Effect in the Context of Human Gastrointestinal and Other Cancers?	57
Review of Shikonin and Derivatives: Isolation, Chemistry, Biosynthesis, Pharmacology and Toxicology	57
Salidroside Attenuates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice and Modulates Inflammation of the Gut-Brain Axis	56

Role of Butyrate, a Gut Microbiota Derived Metabolite, in Cardiovascular Diseases: A comprehensive narrative review	56
Linker Design Impacts Antibody-Drug Conjugate Pharmacokinetics and Efficacy via Modulating the Stability and Payload Release Efficiency	56
Potential Natural Products Against Respiratory Viruses: A Perspective to Develop Anti-COVID-19 Medicines	55
Bibliometric Analysis of the Inflammasome and Pyroptosis in Brain	55
Antitumor Effects of Carvacrol and Thymol: A Systematic Review	55
Phagocytosis, Degranulation and Extracellular Traps Release by Neutrophils—The Current Knowledge, Pharmacological Modulation and Future Prospects	55
Novel Methods and Approaches for Safety Evaluation of Nanoparticle Formulations: A Focus Towards In Vitro Models and Adverse Outcome Pathways	55
Metabolic Profile, Bioactivities, and Variations in the Chemical Constituents of Essential Oils of the Ferula Genus (Apiaceae)	55
Natural Product Erianin Inhibits Bladder Cancer Cell Growth by Inducing Ferroptosis via NRF2 Inactivation	55
Total Flavones of Abelmoschus manihot Ameliorates Podocyte Pyroptosis and Injury in High Glucose Conditions by Targeting METTL3-Dependent m6A Modification-Mediated NLRP3-Inflammasome Activation and PT	54
Maresin1 Protect Against Ferroptosis-Induced Liver Injury Through ROS Inhibition and Nrf2/HO-1/GPX4 Activation	54
Bilirubin Nanoparticles Reduce Diet-Induced Hepatic Steatosis, Improve Fat Utilization, and Increase Plasma β-Hydroxybutyrate	54
Inulin Exerts Beneficial Effects on Non-Alcoholic Fatty Liver Disease via Modulating gut Microbiome and Suppressing the Lipopolysaccharide-Toll-Like Receptor 4-Mψ-Nuclear Factor-κB-Nod-Like Receptor P	54
Receptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer	54
Interleukins 4 and 13 in Asthma: Key Pathophysiologic Cytokines and Druggable Molecular Targets	54
Mitochondrial Iron Overload-Mediated Inhibition of Nrf2-HO-1/GPX4 Assisted ALI-Induced Nephrotoxicity	53
Targeting the Wnt/β-Catenin Signaling Pathway as a Potential Therapeutic Strategy in Renal Tubulointerstitial Fibrosis	53
Knowledge Domain and Emerging Trends in Podocyte Injury Research From 1994 to 2021: A Bibliometric and Visualized Analysis	53
Diabetic Nephropathy: Novel Molecular Mechanisms and Therapeutic Targets	53
Fisetin Rescues the Mice Brains Against D-Galactose-Induced Oxidative Stress, Neuroinflammation and Memory Impairment	53
Therapeutic Applications of Terpenes on Inflammatory Diseases	53
Pharmacokinetics and Excretion of Berberine and Its Nine Metabolites in Rats	53
New Developments in Prokinetic Therapy for Gastric Motility Disorders	53
COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms	52
Favipiravir Versus Arbidol for Clinical Recovery Rate in Moderate and Severe Adult COVID-19 Patients: A Prospective, Multicenter, Open-Label, Randomized Controlled Clinical Trial	52
Dexmedetomidine Attenuates Ferroptosis-Mediated Renal Ischemia/Reperfusion Injury and Inflammation by Inhibiting ACSL4 via α2-AR	52
Current State and Future Directions of Intranasal Delivery Route for Central Nervous System Disorders: A Scientometric and Visualization Analysis	52
Targeting Oxidative Stress as a Therapeutic Approach for Idiopathic Pulmonary Fibrosis	52
Regulatory Mechanisms of Baicalin in Cardiovascular Diseases: A Review	52
Nano and Microparticles as Potential Oral Vaccine Carriers and Adjuvants Against Infectious Diseases	52
Dapagliflozin Alleviates Hepatic Steatosis by Restoring Autophagy via the AMPK-mTOR Pathway	52
Lidocaine Promoted Ferroptosis by Targeting miR-382-5p /SLC7A11 Axis in Ovarian and Breast Cancer	52
The Antimicrobial Potential of the Neem Tree Azadirachta indica	52
Significance of Medicinal Mushrooms in Integrative Oncology: A Narrative Review	52
Efficacy and Safety of Berberine Alone for Several Metabolic Disorders: A Systematic Review and Meta-Analysis of Randomized Clinical Trials	51
A Review of Medicinal Plants with Antiviral Activity Available in Bangladesh and Mechanistic Insight Into Their Bioactive Metabolites on SARS-CoV-2, HIV and HBV	51
Targeting Angiogenesis in Breast Cancer: Current Evidence and Future Perspectives of Novel Anti-Angiogenic Approaches	51
Taohong Siwu Decoction Ameliorates Ischemic Stroke Injury Via Suppressing Pyroptosis	51
Antibiotic Combination Therapy: A Strategy to Overcome Bacterial Resistance to Aminoglycoside Antibiotics	51
Galangin Inhibits Gastric Cancer Growth Through Enhancing STAT3 Mediated ROS Production	51
Analysis of Antidepressant Activity of Huang-Lian Jie-Du Decoction Through Network Pharmacology and Metabolomics	50
Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies	50
Ferulic Acid Ameliorates Atherosclerotic Injury by Modulating Gut Microbiota and Lipid Metabolism	50
Targeting Neutrophils in Sepsis: From Mechanism to Translation	50
Emerging Role of MiR-192-5p in Human Diseases	50
The Potential of Chitosan in Nanomedicine: An Overview of the Cytotoxicity of Chitosan Based Nanoparticles	50
A Review on Plant Bioactive Compounds and Their Modes of Action Against Coronavirus Infection	50
Inflammatory Caspases Drive Pyroptosis in Acute Lung Injury	50
Review of various NAMPT inhibitors for the treatment of cancer	50
Luteolin Ameliorates Experimental Pulmonary Arterial Hypertension via Suppressing Hippo-YAP/PI3K/AKT Signaling Pathway	49
Roles of Macrophages in Atherogenesis	49
The Role of Uptake and Efflux Transporters in the Disposition of Glucuronide and Sulfate Conjugates	49
Maresin 1 Attenuates Lipopolysaccharide-Induced Acute Kidney Injury via Inhibiting NOX4/ROS/NF-κB Pathway	49
Cancer and apoptosis: The apoptotic activity of plant and marine natural products and their potential as targeted cancer therapeutics	49
The Breast Cancer Stem Cells Traits and Drug Resistance	49
The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress	49
Chronic inflammation, cancer development and immunotherapy	49
TLR9 and COVID-19: A Multidisciplinary Theory of a Multifaceted Therapeutic Target	49
Immunomodulatory Effects and Mechanisms of Curcuma Species and Their Bioactive Compounds: A Review	49
Ginger from Farmyard to Town: Nutritional and Pharmacological Applications	49
The efficacy and safety of JAK inhibitors for alopecia areata: A systematic review and meta-analysis of prospective studies	49
Pulmonary Edema in COVID-19 Patients: Mechanisms and Treatment Potential	48
BI 1015550 is a PDE4B Inhibitor and a Clinical Drug Candidate for the Oral Treatment of Idiopathic Pulmonary Fibrosis	48
Self-Medication With Over-the-counter Medicines Among the Working Age Population in Metropolitan Areas of Thailand	48
Insights Into Amentoflavone: A Natural Multifunctional Biflavonoid	48
Advances in Fingerprint Analysis for Standardization and Quality Control of Herbal Medicines	48
Berberine: A Review of its Pharmacokinetics Properties and Therapeutic Potentials in Diverse Vascular Diseases	48
RIPK2 as a New Therapeutic Target in Inflammatory Bowel Diseases	48
Effects of Puerarin on the Prevention and Treatment of Cardiovascular Diseases	48
The Expiry of Humira® Market Exclusivity and the Entry of Adalimumab Biosimilars in Europe: An Overview of Pricing and National Policy Measures	48
Trends in the Immunomodulatory Effects of Cordyceps militaris: Total Extracts, Polysaccharides and Cordycepin	47
Ketamine Use for Cancer and Chronic Pain Management	47
A Review of Treatment of Coronavirus Disease 2019 (COVID-19): Therapeutic Repurposing and Unmet Clinical Needs	47
Anticancer Applications and Pharmacological Properties of Piperidine and Piperine: A Comprehensive Review on Molecular Mechanisms and Therapeutic Perspectives	47
Limitations of Antibiotic MIC-Based PK-PD Metrics: Looking Back to Move Forward	46
Policies to Encourage the Use of Biosimilars in European Countries and Their Potential Impact on Pharmaceutical Expenditure	46
Active Components and Pharmacological Effects of Cornus officinalis: Literature Review	46
Genistein Ameliorates Renal Fibrosis Through Regulation Snail via m6A RNA Demethylase ALKBH5	46
The significance of glycolysis in tumor progression and its relationship with the tumor microenvironment	46
Anti–SARS-CoV-2 Natural Products as Potentially Therapeutic Agents	46
Targeting Neuroinflammation in Brain Cancer: Uncovering Mechanisms, Pharmacological Targets, and Neuropharmaceutical Developments	46
Essential Oils as Multicomponent Mixtures and Their Potential for Human Health and Well-Being	46
Nigella Plants – Traditional Uses, Bioactive Phytoconstituents, Preclinical and Clinical Studies	46
Shenkang Injection and Its Three Anthraquinones Ameliorates Renal Fibrosis by Simultaneous Targeting IƙB/NF-ƙB and Keap1/Nrf2 Signaling Pathways	46
Pharmacological Modulation of Nrf2/HO-1 Signaling Pathway as a Therapeutic Target of Parkinson’s Disease	46
Pioglitazone Inhibits Diabetes-Induced Atrial Mitochondrial Oxidative Stress and Improves Mitochondrial Biogenesis, Dynamics, and Function Through the PPAR-γ/PGC-1α Signaling Pathway	45
Corynoxine Protects Dopaminergic Neurons Through Inducing Autophagy and Diminishing Neuroinflammation in Rotenone-Induced Animal Models of Parkinson’s Disease	45
Neuroinflammatory In Vitro Cell Culture Models and the Potential Applications for Neurological Disorders	45
Targeting Mitochondrial ROS-Mediated Ferroptosis by Quercetin Alleviates High-Fat Diet-Induced Hepatic Lipotoxicity	45
A Review on Drug Delivery System for Tumor Therapy	45
Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases	45
Direct Oral Anticoagulants: From Randomized Clinical Trials to Real-World Clinical Practice	45
Cannabidiol for neurodegenerative disorders: A comprehensive review	44
Influence of Inflammation on Cytochromes P450 Activity in Adults: A Systematic Review of the Literature	44
Investigating Toxin Diversity and Abundance in Snake Venom Proteomes	44