OOIR: Observatory of International Research

Papers

(The H4-Index of Frontiers in Pharmacology is 80. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)

Article	Citations
Editorial: Therapeutic drug monitoring (TDM): a useful tool for pediatric pharmacology applied to routine clinical practice, Volume II	675
Efficacy of interventions with live combined Bacillus subtilis and Enterococcus faecium enteric-coated capsules in metabolic associated fatty liver disease patients: a meta-analysis of randomized cont	365
Individualized, dynamic, and full-course vancomycin dosing prediction: a study on the customized dose model	354
Escitalopram oxalate-loaded chitosan nanoparticle in situ gel formulation intended for direct nose-to-brain delivery: in vitro, ex vivo, and in vivo pharmacokinetic evaluation	331
Quantum chemical calculations of nitrosamine activation and deactivation pathways for carcinogenicity risk assessment	329
Association between hyperuricemia and all-cause mortality in people taken Statins: a retrospective cohort study	311
pH-induced conformational changes in the selectivity filter of a potassium channel lead to alterations in its selectivity and permeation properties	267
Side-stepping the guardian of the genome: current cancer therapeutics targeting mutant p53	216
Modulating mitochondria with natural extract compounds: from bench to clinical therapeutic opportunities for COPD	207
D-cycloserine effects on COPD and depression in a murine experimental model	203
GraphTransNet: predicting epilepsy-related genes using a graph-augmented protein language model	191
Licorice attenuates cisplatin-induced hepatotoxicity by alleviating endoplasmic reticulum stress and apoptosis	190
Traditional Chinese medicine in the prevention of diabetes mellitus and cardiovascular complications: mechanisms and therapeutic approaches	180
Gegen Qinlian decoction prevents post-ERCP pancreatitis by regulating NLRP3 inflammasome-mediated pyroptosis	173
Hydroxytyrosol Inhibits MDSCs and Promotes M1 Macrophages in Mice With Orthotopic Pancreatic Tumor	170
Efficacy, safety and mechanism of Honghua Xiaoyao Pill in the treatment of peri-menopausal syndrome: A study protocol for a randomized controlled trial	169
Traditional Chinese Medicine in Treating Primary Podocytosis: From Fundamental Science to Clinical Research	164
Unraveling the pathogenic mechanism of a novel filamin a frameshift variant in periventricular nodular heterotopia	161
Therapeutic drug monitoring practices of anti-infectives: An Asia-wide cross-sectional survey	154
Quantifying the integrated physiological effects of endothelin-1 on cardiovascular and renal function in healthy subjects: a mathematical modeling analysis	147
Assessment of Fasudil on Contrast-Associated Acute Kidney Injury Using Multiparametric Renal MRI	146
Editorial: Chronic pain: what is the mechanism?	143
Long-term clinical course and outcomes of patients with microscopic polyangiitis-associated interstitial lung disease	140
Indirect effect of alpha-1-antitrypsin on endotoxin-induced IL-1β secretion from human PBMCs	133
Corrigendum: Xenon attenuated neonatal lipopolysaccharide exposure induced neuronal necroptosis and subsequently improved cognition in juvenile rats	131

Editorial: Oral mucosa and disorders: from drug discovery to development and translation	130
Pre- and post-chemotherapy spermatogenesis in male patients with malignant bone and soft tissue tumors	128
Time trends and regional variations in prices of anticancer medicines in China	128
The categorizations of vasculogenic mimicry in clear cell renal cell carcinoma unveil inherent connections with clinical and immune features	127
Advances in the study of Ophiopogon japonicus polysaccharides: structural characterization, bioactivity and gut microbiota modulation regulation	127
Editorial: Impact of anesthetics on cancer behavior and outcome	125
Cyclohexene oxide CA, a derivative of zeylenone, exhibits anti-cancer activity in glioblastoma by inducing G0/G1 phase arrest through interference with EZH2	122
Unlocking cellular traffic jams: olive oil-mediated rescue of CNG mutant channels	121
Erratum: Isoflurane-lipid emulsion injection as an anticonvulsant and neuroprotectant treatment for nerve agent exposure	119
Editorial: Interplays and Functions of Gaseous Mediators: From Underlying Mechanisms to Therapeutic Approaches in Cardiovascular Diseases	118
Sputum microbe community alterations induced by long-term inhaled corticosteroid use are associated with airway function in chronic obstructive pulmonary disease patients based on metagenomic next-gen	117
Therapeutic drug monitoring of voriconazole and the impact of inflammation on plasma trough concentrations in children	117
Ginseng and Polygonum multiflorum formula protects brain function in Alzheimer’s disease	116
Impact of domiciliary administration of NSAIDs on COVID-19 hospital outcomes: an unCoVer analysis	115
RRx-001 Exerts Neuroprotection Against LPS-Induced Microglia Activation and Neuroinflammation Through Disturbing the TLR4 Pathway	114
AduCPI2 alleviates MSU-induced acute gouty arthritis in mice by inhibiting cathepsin S and the C5a-C5aR1 axis	113
Integration of meta-analysis and network pharmacology analysis to investigate the pharmacological mechanisms of traditional Chinese medicine in the treatment of hepatocellular carcinoma	112
Editorial: Methods in predictive toxicology 2023	111
Efficacy and safety profile of biotechnological agents and Janus kinase inhibitors in VEXAS syndrome: data from the international AIDA Network VEXAS registry	109
Efficacy and safety of Abelmoschus moschatus capsules combined with tripterygium glycoside tablets on diabetic nephropathy: A systematic review and meta-analysis	109
Effects of long-term antipsychotic medication on brain instability in first-episode schizophrenia patients: a resting-state fMRI study	107
Corrigendum: Shu-Xie decoction alleviates oxidative stress and colon injury in acute sleep-deprived mice by suppressing p62/KEAP1/NRF2/HO1/NQO1 signaling	106
Plasma calcitonin gene-related peptide and nitric oxide predict therapeutic response to amlodipine in pediatric primary hypertension	105
Integrating single-cell RNA-seq, bulk RNA-seq and network pharmacology reveals protective effect of salidroside in peritoneal dialysis-associated peritoneal fibrosis	105
Pre-clinical toxicity assessment of Artemisia absinthium extract-loaded polymeric nanoparticles associated with their oral administration	104
Strategies for salvage therapy post CAR-T therapy failure in refractory/relapsed multiple myeloma patients	103
Chinese herbal compound for multidrug-resistant or extensively drug-resistant bacterial pneumonia: a meta-analysis and trial sequential analysis with association rule mining to identify core herb comb	103
Associations between ionomic profile and metabolic abnormalities in a murine model of sodium sulfide induced alopecia areata	103
Safety evaluation of medroxyprogesterone acetate: a pharmacovigilance analysis using FDA adverse event reporting system data	102
Nodosin Exerts an Anti-Colorectal Cancer Effect by Inhibiting Proliferation and Triggering Complex Cell Death in Vitro and in Vivo	101
Corrigendum: The Extract of Sonneratia apetala Leaves and Branches Ameliorates Hyperuricemia in Mice by Regulating Renal Uric Acid Transporters and Suppressing the Activation of the JAK/STAT Signaling	100
Long-term administration of bumetanide improve functional recovery after spinal cord injury in rats	94
Differences in right ventricular function and response to targeted therapy between patients with IPAH and PAH-CHD	91
Role of ferroptosis in atrial fibrillation: a review	91
Neuroprotective effect of dexmedetomidine on autophagy in mice administered intracerebroventricular injections of Aβ25–35	91
Editorial: Utilizing omics strategies to discover new drug targets for cancers	90
Ninjin’yoeito ameliorated PPE-induced pulmonary emphysema and anxiety/depressive-like behavior in aged C57BL/6J mice	90
Shuxie-1 Decoction Alleviated CUMS -Induced Liver Injury via IL-6/JAK2/STAT3 Signaling	90
The efficacy of aminosalicylates in acute radiation enteritis: a systematic review and meta-analysis	89
Editorial: Autoimmune and Inflammatory Rheumatic Diseases: Identifying Biomarkers of Response to Therapy With Biologics	89
Effect of Fu Zheng Jie Du Formula on outcomes in patients with severe pneumonia receiving prone ventilation: a retrospective cohort study	88
Potential efficacy and mechanisms of icariin for the animal model of osteonecrosis of the femoral head	88
The functional significance of vascular DNA hypermethylation in atherosclerosis: a historical perspective	88
Exploration of the Mechanism of Salvianolic Acid for Injection Against Ischemic Stroke: A Research Based on Computational Prediction and Experimental Validation	87
CDFA: Calibrated deep feature aggregation for screening synergistic drug combinations	86
Antisense Oligonucleotide-Based Therapy on miR-181a-5p Alleviates Cartilage Degradation of Temporomandibular Joint Osteoarthritis via Promoting SIRT1	85
Natural drugs targeting inflammation pathways can be used to treat atherosclerosis	85
mPEG-PDLLA Micelles Potentiate Docetaxel for Intraperitoneal Chemotherapy in Ovarian Cancer Peritoneal Metastasis	84
Does preterm birth increase the initiation of antidepressant use during the postpartum? A population-based investigation	84
Pharmacokinetics and absorption mechanism of tandospirone citrate	82

Chemical synthesis of a reported p47phox/p22phox inhibitor and characterization of its instability and irreproducible activity	82
A Novel Compound, Tanshinol Borneol Ester, Ameliorates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Oxidative Stress via the mTOR/β-TrCP/NRF2 Pathway	81
Case Report: Rhabdomyolysis secondary to vildagliptin overdose in a suicidal attempt: A case report and brief literature review	81
Network pharmacology and experimental verification-based strategy to explore the underlying mechanism of Liu Jun An Wei formula in the treatment of gastrointestinal reactions caused by chemotherapy fo	81
Development of a vaccine against the synthetic opioid U-47700	80
Hepatoprotective Efficacy and Interventional Mechanism of Qijia Rougan Decoction in Liver Fibrosis	80
Naoxintong capsule for treating cardiovascular and cerebrovascular diseases: from bench to bedside	80
Potential mechanisms of Lian-Zhi-Fan solution for TNBS-induced ulcerative colitis in rats via a metabolomics approach	80
Interleukin 22 and its association with neurodegenerative disease activity	80