OOIR: Observatory of International Research

Papers

(The H4-Index of Frontiers in Pharmacology is 82. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic	818
Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications	330
The Bone Extracellular Matrix in Bone Formation and Regeneration	315
Advances in Oral Drug Delivery	280
Cell-Penetrating Peptides in Diagnosis and Treatment of Human Diseases: From Preclinical Research to Clinical Application	271
Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors	249
Molecular Sets (MOSES): A Benchmarking Platform for Molecular Generation Models	243
The Drug-Resistance Mechanisms of Five Platinum-Based Antitumor Agents	242
Advances in Oral Drug Delivery for Regional Targeting in the Gastrointestinal Tract - Influence of Physiological, Pathophysiological and Pharmaceutical Factors	215
Dietary Polyphenols and Their Role in Oxidative Stress-Induced Human Diseases: Insights Into Protective Effects, Antioxidant Potentials and Mechanism(s) of Action	207
Nanocurcumin: A Promising Candidate for Therapeutic Applications	200
Modeling Parkinson’s Disease With the Alpha-Synuclein Protein	186
A Review of the Pharmacological Action of Astragalus Polysaccharide	179
Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety	175
COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?	166
Perceptions of healthcare professionals and patients on the role of the pharmacist in TB management in Pakistan: A qualitative study	163
DNA Repair Pathways in Cancer Therapy and Resistance	162
PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease	162
Ferroptosis and Its Potential Role in Human Diseases	159
Activation of PI3K/AKT/mTOR Pathway Causes Drug Resistance in Breast Cancer	156
Herb and Spices in Colorectal Cancer Prevention and Treatment: A Narrative Review	150
The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action	146
Uric Acid and Cardiovascular Disease: An Update From Molecular Mechanism to Clinical Perspective	143
A Snapshot of the Global Race for Vaccines Targeting SARS-CoV-2 and the COVID-19 Pandemic	142
Comparative effectiveness of individualized longer and standardized shorter regimens in the treatment of multidrug resistant tuberculosis in a high burden country	141

From Animal Poisons and Venoms to Medicines: Achievements, Challenges and Perspectives in Drug Discovery	141
Histone Deacetylases Inhibitors in Neurodegenerative Diseases, Neuroprotection and Neuronal Differentiation	139
The Role of the CXCL12/CXCR4/CXCR7 Chemokine Axis in Cancer	139
SIRT1 Activation by Natural Phytochemicals: An Overview	139
PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy	138
Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence	137
Discovering Anti-Cancer Drugs via Computational Methods	137
Overview of OxLDL and Its Impact on Cardiovascular Health: Focus on Atherosclerosis	136
Comprehensive Analysis of Cuproptosis-Related Genes in Immune Infiltration and Prognosis in Melanoma	132
Phytosterols: From Preclinical Evidence to Potential Clinical Applications	130
Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia	130
Fluvoxamine: A Review of Its Mechanism of Action and Its Role in COVID-19	128
PD-1/PD-L1 Checkpoint Inhibitors in Tumor Immunotherapy	127
Response to the Novel Corona Virus (COVID-19) Pandemic Across Africa: Successes, Challenges, and Implications for the Future	127
Effect of Berberine on Atherosclerosis and Gut Microbiota Modulation and Their Correlation in High-Fat Diet-Fed ApoE−/− Mice	123
Medicinal Plants as Sources of Active Molecules Against COVID-19	121
Unraveling Plant Natural Chemical Diversity for Drug Discovery Purposes	121
Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review	113
Non-Alcoholic Steatohepatitis: A Review of Its Mechanism, Models and Medical Treatments	111
Fat Therapeutics: The Clinical Capacity of Adipose-Derived Stem Cells and Exosomes for Human Disease and Tissue Regeneration	110
Knowledge Mapping of Drug-Induced Liver Injury: A Scientometric Investigation (2010–2019)	109
Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research	107
The Pharmacological Action of Kaempferol in Central Nervous System Diseases: A Review	106
Progressive 3D Printing Technology and Its Application in Medical Materials	103
Oral Curcumin With Piperine as Adjuvant Therapy for the Treatment of COVID-19: A Randomized Clinical Trial	103
AKT Inhibitors: New Weapons in the Fight Against Breast Cancer?	102
Cellular and Molecular Pathways of COVID-19 and Potential Points of Therapeutic Intervention	102
Clinically-Relevant ABC Transporter for Anti-Cancer Drug Resistance	101
Neurodegenerative Disease and the NLRP3 Inflammasome	101
Resveratrol Modulates the Gut Microbiota and Inflammation to Protect Against Diabetic Nephropathy in Mice	101
P2X7 in Cancer: From Molecular Mechanisms to Therapeutics	101
A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective	100
Anti-SARS-CoV Natural Products With the Potential to Inhibit SARS-CoV-2 (COVID-19)	98
Combination of Ruxolitinib and Eculizumab for Treatment of Severe SARS-CoV-2-Related Acute Respiratory Distress Syndrome: A Controlled Study	97
Mesenchymal Stem Cell–Derived Exosomes: A Promising Biological Tool in Nanomedicine	97
Cellular Mechanisms of Liver Fibrosis	96
Novel and Emerging Therapies for Inflammatory Bowel Disease	94
Challenges for Drug Repurposing in the COVID-19 Pandemic Era	94
Heavy Metal Contaminations in Herbal Medicines: Determination, Comprehensive Risk Assessments, and Solutions	94
Neutrophilia and NETopathy as Key Pathologic Drivers of Progressive Lung Impairment in Patients With COVID-19	93
Recent Advances in NAMPT Inhibitors: A Novel Immunotherapic Strategy	93
Current Prevention of COVID-19: Natural Products and Herbal Medicine	92
Interplay of EMT and CSC in Cancer and the Potential Therapeutic Strategies	92
A Review on the Potential Use of Medicinal Plants From Asteraceae and Lamiaceae Plant Family in Cardiovascular Diseases	91
The Role of Oxidative Stress and Natural Antioxidants in Ovarian Aging	88
Pharmacogenetics Guidelines: Overview and Comparison of the DPWG, CPIC, CPNDS, and RNPGx Guidelines	88
Passiflora edulis: An Insight Into Current Researches on Phytochemistry and Pharmacology	87
The Evasion Mechanisms of Cancer Immunity and Drug Intervention in the Tumor Microenvironment	87
Baicalin Prevents Myocardial Ischemia/Reperfusion Injury Through Inhibiting ACSL4 Mediated Ferroptosis	87
Drug Shortage: Causes, Impact, and Mitigation Strategies	86

The Drug Repurposing for COVID-19 Clinical Trials Provide Very Effective Therapeutic Combinations: Lessons Learned From Major Clinical Studies	86
Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer's Disease	86
G Protein-Coupled Receptors in Taste Physiology and Pharmacology	86
Immunosuppressive Drugs and COVID-19: A Review	85
Advanced Approaches to Breast Cancer Classification and Diagnosis	85
Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits	85
Repurposing Drugs, Ongoing Vaccine, and New Therapeutic Development Initiatives Against COVID-19	84
Pathways Connecting Late-Life Depression and Dementia	82