OOIR: Observatory of International Research

Papers

(The H4-Index of Frontiers in Pharmacology is 80. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)

Article	Citations
Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic	1161
Advances in Oral Drug Delivery	376
Perceptions of healthcare professionals and patients on the role of the pharmacist in TB management in Pakistan: A qualitative study	365
Dietary Polyphenols and Their Role in Oxidative Stress-Induced Human Diseases: Insights Into Protective Effects, Antioxidant Potentials and Mechanism(s) of Action	336
Herb and Spices in Colorectal Cancer Prevention and Treatment: A Narrative Review	314
Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors	313
Molecular Sets (MOSES): A Benchmarking Platform for Molecular Generation Models	313
Comparative effectiveness of individualized longer and standardized shorter regimens in the treatment of multidrug resistant tuberculosis in a high burden country	301
PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease	215
DNA Repair Pathways in Cancer Therapy and Resistance	199
Activation of PI3K/AKT/mTOR Pathway Causes Drug Resistance in Breast Cancer	192
PD-1/PD-L1 Checkpoint Inhibitors in Tumor Immunotherapy	182
Uric Acid and Cardiovascular Disease: An Update From Molecular Mechanism to Clinical Perspective	181
Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence	166
PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy	166
The Role of the CXCL12/CXCR4/CXCR7 Chemokine Axis in Cancer	163
Overview of OxLDL and Its Impact on Cardiovascular Health: Focus on Atherosclerosis	160
Comprehensive Analysis of Cuproptosis-Related Genes in Immune Infiltration and Prognosis in Melanoma	160
Phytosterols: From Preclinical Evidence to Potential Clinical Applications	157
The Evasion Mechanisms of Cancer Immunity and Drug Intervention in the Tumor Microenvironment	154
Non-Alcoholic Steatohepatitis: A Review of Its Mechanism, Models and Medical Treatments	141
AKT Inhibitors: New Weapons in the Fight Against Breast Cancer?	138
Fluvoxamine: A Review of Its Mechanism of Action and Its Role in COVID-19	137
A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective	136
Clinically-Relevant ABC Transporter for Anti-Cancer Drug Resistance	128

A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin	128
Research progress of glutathione peroxidase family (GPX) in redoxidation	127
Neurodegenerative Disease and the NLRP3 Inflammasome	122
Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research	121
Remimazolam: Non-Clinical and Clinical Profile of a New Sedative/Anesthetic Agent	121
The Pharmacological Action of Kaempferol in Central Nervous System Diseases: A Review	121
Oral Curcumin With Piperine as Adjuvant Therapy for the Treatment of COVID-19: A Randomized Clinical Trial	120
Mesenchymal Stem Cell–Derived Exosomes: A Promising Biological Tool in Nanomedicine	117
Heavy Metal Contaminations in Herbal Medicines: Determination, Comprehensive Risk Assessments, and Solutions	117
Drug Shortage: Causes, Impact, and Mitigation Strategies	116
Baicalin Prevents Myocardial Ischemia/Reperfusion Injury Through Inhibiting ACSL4 Mediated Ferroptosis	113
Cellular Mechanisms of Liver Fibrosis	112
G Protein-Coupled Receptors in Taste Physiology and Pharmacology	111
Exploring Phytochemicals for Combating Antibiotic Resistance in Microbial Pathogens	110
Novel and Emerging Therapies for Inflammatory Bowel Disease	110
Idiopathic Pulmonary Fibrosis: An Update on Pathogenesis	108
The Role of Oxidative Stress and Natural Antioxidants in Ovarian Aging	106
The Drug Repurposing for COVID-19 Clinical Trials Provide Very Effective Therapeutic Combinations: Lessons Learned From Major Clinical Studies	106
Advanced Approaches to Breast Cancer Classification and Diagnosis	106
Genistein: A Review on its Anti-Inflammatory Properties	106
Pharmacogenetics Guidelines: Overview and Comparison of the DPWG, CPIC, CPNDS, and RNPGx Guidelines	103
Challenges for Drug Repurposing in the COVID-19 Pandemic Era	102
Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer's Disease	101
Current Prevention of COVID-19: Natural Products and Herbal Medicine	101
Targeting the Integrated Stress Response in Cancer Therapy	101
Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application	100
Polyphenols as Antitumor Agents Targeting Key Players in Cancer-Driving Signaling Pathways	98
Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits	98
Natural Compounds With Antimicrobial and Antiviral Effect and Nanocarriers Used for Their Transportation	98
The Role of Tumor Inflammatory Microenvironment in Lung Cancer	96
SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases	96
Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators—What is the Evidence so far?	94
Progress in the Understanding of the Mechanism of Tamoxifen Resistance in Breast Cancer	92
System Xc−/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy	92
Functions and Diseases of the Retinal Pigment Epithelium	92
Neuropharmacological Effects of Quercetin: A Literature-Based Review	92
Best Practice in the chemical characterisation of extracts used in pharmacological and toxicological research—The ConPhyMP—Guidelines12	91
Psychedelic Communitas: Intersubjective Experience During Psychedelic Group Sessions Predicts Enduring Changes in Psychological Wellbeing and Social Connectedness	89
Trends in Antidiabetic Drug Discovery: FDA Approved Drugs, New Drugs in Clinical Trials and Global Sales	89
FDX1 can Impact the Prognosis and Mediate the Metabolism of Lung Adenocarcinoma	87
Analgesic Effect of Acetaminophen: A Review of Known and Novel Mechanisms of Action	87
Pharmacological Effects of Salvianolic Acid B Against Oxidative Damage	86
Mechanisms of Chemotherapy-Induced Neurotoxicity	86
Curcumin as a Potential Treatment for COVID-19	85
Targeting Neutrophils to Treat Acute Respiratory Distress Syndrome in Coronavirus Disease	84
Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease	84
Oxidative Stress and Hyper-Inflammation as Major Drivers of Severe COVID-19 and Long COVID: Implications for the Benefit of High-Dose Intravenous Vitamin C	83
Baicalin Inhibits Ferroptosis in Intracerebral Hemorrhage	83
Clinical Review: Navitoclax as a Pro-Apoptotic and Anti-Fibrotic Agent	83
Post-treatment With Irisin Attenuates Acute Kidney Injury in Sepsis Mice Through Anti-Ferroptosis via the SIRT1/Nrf2 Pathway	82

Understanding the role of the gut microbiome in gastrointestinal cancer: A review	82
New Insights Into Gut-Bacteria-Derived Indole and Its Derivatives in Intestinal and Liver Diseases	81
Eicosanoids in Cancer: New Roles in Immunoregulation	81
Clinical Insights Into Novel Immune Checkpoint Inhibitors	80
Fisetin Attenuates Doxorubicin-Induced Cardiomyopathy In Vivo and In Vitro by Inhibiting Ferroptosis Through SIRT1/Nrf2 Signaling Pathway Activation	80
Insight Into the Prospects for RNAi Therapy of Cancer	80