OOIR: Observatory of International Research

Papers

(The H4-Index of Frontiers in Pharmacology is 84. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Association between hyperuricemia and all-cause mortality in people taken Statins: a retrospective cohort study	569
pH-induced conformational changes in the selectivity filter of a potassium channel lead to alterations in its selectivity and permeation properties	380
GraphTransNet: predicting epilepsy-related genes using a graph-augmented protein language model	368
Quantifying the integrated physiological effects of endothelin-1 on cardiovascular and renal function in healthy subjects: a mathematical modeling analysis	339
Editorial: Chronic pain: what is the mechanism?	318
Time trends and regional variations in prices of anticancer medicines in China	317
Editorial: Impact of anesthetics on cancer behavior and outcome	310
Unlocking cellular traffic jams: olive oil-mediated rescue of CNG mutant channels	302
Impact of domiciliary administration of NSAIDs on COVID-19 hospital outcomes: an unCoVer analysis	230
Differences in right ventricular function and response to targeted therapy between patients with IPAH and PAH-CHD	226
Effect of Fu Zheng Jie Du Formula on outcomes in patients with severe pneumonia receiving prone ventilation: a retrospective cohort study	217
Potential efficacy and mechanisms of icariin for the animal model of osteonecrosis of the femoral head	209
Case Report: Rhabdomyolysis secondary to vildagliptin overdose in a suicidal attempt: A case report and brief literature review	201
Development of a vaccine against the synthetic opioid U-47700	186
Association between antihypertensive drugs and oral cancer: a drug target Mendelian randomization study	184
Research hotspots and trend analysis of cell transplantation in traumatic spinal cord injury: a bibliometric and visualized analysis	183
Editorial: Women in nanomedicine	178
Comparison of pharmacokinetics and safety between CE-fosphenytoin sodium, fosphenytoin sodium, and phenytoin sodium after intravenous and intramuscular administration in healthy volunteers	176
Editorial: Leukocyte biology and muscle pathology: Leukocytes as potential targets to control muscle inflammation, mass, and pain	176
Editorial: Evolution of phytochemicals and phytotherapies in the treatment and management of cancer: targeted strategies in cancer precision medicine	173
Drug-drug interactions between antithrombotics and direct-acting antivirals in hepatitis C virus (HCV) patients: A brief, updated report	171
Non-aromatizable androgens modulate the lipopolysaccharide induced expression of the P2X7 receptor in human adipocytes	157
Significance of LRFN4 in prognosis and tumor microenvironment of lung adenocarcinoma	153
Editorial: Advances on targeted nanomedicines for atherosclerosis	143
Influence of the ABCB1-rs1045642 gene polymorphism on blood drug concentration in voriconazole-treated patients with severe invasive fungal infection	141

A retrospective analysis of factors associated with the length of hospital stay in COVID-19 patients treated with Nirmatrelvir / Ritonavir	133
Evaluation of variable new antigen receptors (vNARs) as a novel cathepsin S (CTSS) targeting strategy	130
Androgen receptor inhibitor ameliorates pulmonary arterial hypertension by enhancing the apoptosis level through suppressing the Notch3/Hes5 pathway	128
Cymensifin A: a promising pharmaceutical candidate to defeat lung cancer via cellular reactive oxygen species-mediated apoptosis	126
Case report: Dezocine’s rapid and sustained antidepressant effects	124
A nano-preparation approach to enable the delivery of daphnoretin to potentiate the therapeutical efficacy in hepatocellular cancer	124
Menisoxoisoaporphine A, a novel oxoisoaporphine alkaloid from Menispermi Rhizoma, inhibits inflammation by targeting PDE4B	122
The clinically applied PARP inhibitor talazoparib ameliorates imiquimod-induced psoriasis in mice without reducing skin inflammation	120
Male mice treated with combined anti-fibrotic therapeutics, IPW5371 and tadalafil, are predisposed to adverse cardiovascular events	117
The clinical value of screening for acetaminophen in all patients with intentional overdose or altered mental status suspected to be secondary to overdose	115
Which is the optimal choice in lipid-lowering therapy for reducing major cardiovascular events? a network meta-analysis	114
Network pharmacology-based and experimental identification of the effects of Renshen Yangrong decoction on myocardial infarction	113
Cost-effectiveness of empagliflozin for the treatment of heart failure: a systematic review	111
Tailoring second-line or above therapy for patients with advanced or metastatic gastric cancer: A multicenter real-world study	111
The macrocyclic lactone oxacyclododecindione reduces fibrosis progression	110
Editorial: Streaming inflammation: From damage to healing and resilience–Volume II	109
Natural drugs targeting inflammation pathways can be used to treat atherosclerosis	107
Inhibition of PPARγ by BZ26, a GW9662 derivate, attenuated obesity-related breast cancer progression by inhibiting the reprogramming of mature adipocytes into to cancer associate adipocyte-like cells	107
Editorial: Genomic discoveries and pharmaceutical development in urologic tumors	106
Commentary: Iridoids derived from Valeriana jatamansi jones alleviates neuroinflammation and blood spinal cord barrier permeability after spinal cord injury by activating the Nrf2/HO-1 signaling pathw	106
Cytotoxicity and reversal effect of sertraline, fluoxetine, and citalopram on MRP1- and MRP7-mediated MDR	106
Dopaminergic REST is implicated in the tamoxifen-induced neuroprotection against manganese toxicity in female mice	106
Integrated chemometric evaluation of morphological traits, chemical composition, and hepatotoxicity of Polygonum multiflorum	104
Optimization of gabapentin dosage in pediatric patients with renal impairment: a physiologically based pharmacokinetic modeling approach	103
Icotinib derivatives as tyrosine kinase inhibitors with anti-esophageal squamous carcinoma activity	103
Ex vivo perfusion model of mouse liver and its application to analyze the effects of OCT1 deficiency	102
Accidental cannabis intoxication in two young children: clinical presentation and toxicokinetics - a case series	102
Interaction and potential mechanisms between atorvastatin and voriconazole, agents used to treat dyslipidemia and fungal infections	101
Protective effects of insulin on dry eye syndrome via TLR4/NF-κB pathway: based on network pharmacology and in vitro experiments validation	99
Safety profile of lutein-based blue dyes and surgical lights	99
Evaluation of standard use of intravenous infusion in 25 general hospitals in Shanxi province based on factor analysis and cluster analysis	99
Editorial: Big data for biomedical research of inflammatory diseases	98
Strategies for salvage therapy post CAR-T therapy failure in refractory/relapsed multiple myeloma patients	98
The efficacy of aminosalicylates in acute radiation enteritis: a systematic review and meta-analysis	97
Is it possible to diagnose therapeutic adherence in mild cognitive impairment and dementia patients in clinical practice?	97
Functional characterization of the α1-adrenoceptor in adult male rat locus coeruleus neurons ex vivo	96
Acute myocardial infarction induced by avatrombopag: a case report	96
Machine learning methods for propensity and disease risk score estimation in high-dimensional data: a plasmode simulation and real-world data cohort analysis	95
The Amazonian kambô frog Phyllomedusa bicolor (Amphibia: Phyllomedusidae): Current knowledge on biology, phylogeography, toxinology, ethnopharmacology and medical aspects	95
8 specific Chinese herbal injections combined with chemotherapy for breast cancer: a systematic review and network meta-analysis of comparative safety and efficacy	95
Recent clinical evidence on nutrition, novel pharmacotherapy, and vaccination in inflammatory bowel diseases	92
Efficacy, safety and mechanism of Honghua Xiaoyao Pill in the treatment of peri-menopausal syndrome: A study protocol for a randomized controlled trial	90
Barriers to prescribing and insurance approval of SGLT2 inhibitors for heart failure: a mixed-methods study in Jordan	90
Investigating the therapeutic potential of hesperidin targeting CRISP2 in intervertebral disc degeneration and cancer risk mitigation	90
Integrating single-cell RNA-seq, bulk RNA-seq and network pharmacology reveals protective effect of salidroside in peritoneal dialysis-associated peritoneal fibrosis	89
Doxycycline for the treatment of breast cancer-related lymphedema	89
A machine learning model integrating gut microbiota biomarkers for predicting neurological recovery after cerebral hypoxia-ischemia: a single-center study augmented with public data	89
Wendan decoction in the treatment of nonalcoholic fatty liver disease: A systematic review and meta-analysis	88
Targeting cancer with delphinidin: from molecular insights to therapeutic implications	88
SARS-CoV-2 infection dysregulates the expression of clinically relevant drug metabolizing enzymes in Vero E6 cells and membrane transporters in human lung tissues	87

Correction: Efficacy and safety of oral Chinese medicine combined with chemotherapy: a systematic review and network meta-analysis	87
Sishen Pill and its active phytochemicals in treating inflammatory bowel disease and colon cancer: an overview	85
Does preterm birth increase the initiation of antidepressant use during the postpartum? A population-based investigation	85
Ivarmacitinib reduces the need for adding/escalating medications in moderate-to-severe rheumatoid arthritis patients: a post hoc analysis from a phase III trial	85
Potential mechanisms of Lian-Zhi-Fan solution for TNBS-induced ulcerative colitis in rats via a metabolomics approach	85
A minimal PBPK model to accelerate preclinical development of drugs against tuberculosis	85
Biomimetic astragaloside-IV-loaded mesoporous silica nanoparticles for treatment of dilated cardiomyopathy	84
Effect of age and ICU types on mortality in invasive mechanically ventilated patients with sepsis receiving dexmedetomidine: a retrospective cohort study with propensity score matching	84
Exploring the mechanism of baicalein on choroid melanoma based on network pharmacology, transcriptomics and experimental verification	84
Clinical study of ganshuang granule combined with tenofovir in the treatment of chronic hepatitis B complicated with nonalcoholic fatty liver disease	84