OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Innate Immunity is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Human Ribonuclease 6 Has a Protective Role during Experimental Urinary Tract Infection	48
Expansion of Phenotypically Altered Dendritic Cell Populations in the Small Airways and Alveolar Parenchyma in Patients with Chronic Obstructive Pulmonary Disease	29
Obituary of Prof. Uli Theopold, 1957–2023	29
Regulation of TLR10 Expression and Its Role in Chemotaxis of Human Neutrophils	26
Type I interferon, induced by adenovirus or adenoviral vector infection, regulates the cytokine response to LPS in a macrophage type-specific manner	24
Mechanisms and Therapeutic Strategies for MAFLD Targeting TLR4 Signaling Pathways	24
Murine Ribonuclease 6 Limits Bacterial Dissemination During Experimental Urinary Tract Infection	23
Metabolism Shapes Immune Responses to <i>Staphylococcus aureus</i>	23
Differential Recognition of Lipopolysaccharide O-Antigens by the Pattern Recognition Molecules MBL and Ficolins of the Complement System	22
Macrophage-Biomimetic Nanoparticles Ameliorate Ulcerative Colitis through Reducing Inflammatory Factors Expression	22
Farewell to Professors Arne Egesten and Heiko Herwald	22
Broad Ultrastructural and Transcriptomic Changes Underlie the Multinucleated Giant Hemocyte Mediated Innate Immune Response against Parasitoids	21
Human Blood Non-Classical/Classical Monocyte Cells Are Heterogeneously Presented in Severe COVID-19 and Correlate with Disease Activity	21
<i>Ehrlichia chaffeensis</i> Co-Opts Phagocytic Hemocytes for Systemic Dissemination in the Lone Star Tick, <i>Amblyomma americanum</i>	19
Acknowledgement to Reviewers	18
The Role of Ficolins in Lung Injury	18
Innate Immune Training with Bacterial Extracts Enhances Lung Macrophage Recruitment to Protect from Betacoronavirus Infection	18
Streptococcus pyogenes Activates Human Platelets via Streptolysin S-Mediated Calcium Ion Influx	17
Activation of NLRP3 Inflammasome Complexes by Beta-Tricalcium Phosphate Particles and Stimulation of Immune Cell Migration in vivo	16
Pro-Inflammatory of PRDM1/SIRT2/NLRP3 Axis in Monosodium Urate-Induced Acute Gouty Arthritis	15
CLIPA7 Exhibits Pleiotropic Roles in the <b><i>Anopheles gambiae</i></b> Immune Response	15
GDF15 Suppresses Lymphoproliferation and Humoral Autoimmunity in a Murine Model of Systemic Lupus Erythematosus	14
Perilipin 1 Deficiency Prompts Lipolysis in Lipid Droplets and Aggravates the Pathogenesis of Persistent Immune Activation in <i>Drosophila</i>	14
Lipoteichoic Acids Are Essential for Pneumococcal Colonization and Membrane Integrity	14
Complex Thrombo-Inflammatory Responses versus Outcomes of Non-COVID-19 Community-Acquired Pneumonia and COVID-19	14

<b><i>Streptococcus pneumoniae</i></b> Impairs Maturation of Human Dendritic Cells and Consequent Activation of CD4<sup>+</sup> T Cells via Pneumolysin	14
N6-Methyladenosine (m6A) Modification in Natural Immune Cell-Mediated Inflammatory Diseases	13
YTHDC1-Modified m6A Methylation of Hsa_circ_0102678 Promotes Keratinocyte Inflammation Induced by <i>Cutibacterium acnes</i> Biofilm through Regulating miR-146a/TRAF6 and IRAK1 Axis	13
Tollip Inhibits IL-33 Release and Inflammation in Influenza A Virus-Infected Mouse Airways	13
Unraveling the Complex Nexus of Macrophage Metabolism, Periodontitis, and Associated Comorbidities	12
The Role of Neutrophil in COVID-19 — Positive or Negative	12
miR-142-5p Encapsulated by Serum-Derived Extracellular Vesicles Protects against Acute Lung Injury in Septic Rats following Remote Ischemic Preconditioning via the PTEN/PI3K/Akt Axis	11
Glyceraldehyde-3-Phosphate Dehydrogenase Binds with Spike Protein and Inhibits the Entry of SARS-CoV-2 into Host Cells	11
Increase in the Complement Activation Product C4d and the Terminal Complement Complex sC5b-9 Is Associated with Disease Severity and a Fatal Outcome in Necrotizing Soft-Tissue Infection	11
Dysregulated Immunometabolism Is Associated with the Generation of Myeloid-Derived Suppressor Cells in <b><i>Staphylococcus aureus</i></b> Chronic Infection	10
Combined Heterozygous Genetic Variations in Complement C2 and C8B: An Explanation for Multidimensional Immune Imbalance?	10
The Gene Signature of Activated M-CSF-Primed Human Monocyte-Derived Macrophages Is IL-10-Dependent	10
Yin and Yang of Biofilm Formation and Cyclic di-GMP Signaling of the Gastrointestinal Pathogen <b><i>Salmonella enterica</i></b> Serovar Typhimurium	10
IRF1 Is Required for MDA5 (IFIH1) Induction by IFN-α, LPS, and poly(I:C) in Murine Macrophages	10
Vitamin D Enhances Neutrophil Generation and Function in Zebrafish (<b><i>Danio rerio</i></b>)	10
TLR10: An intriguing Toll-like receptor with many unanswered questions	10
Interleukin-33 Ameliorates Murine Systemic Lupus Erythematosus and Is Associated with Induction of M2 Macrophage Polarisation and Regulatory T Cells	10
Development and Characterization of Novel ELISAs for the Specific Quantification of the Factor H-Related Proteins 2, 3, 4, and 5	10
The Dynamics of Circulating Heparin-Binding Protein: Implications for Its Use as a Biomarker	9
Interactions of Probiotics with the Immune Cells of Patients with COVID-19 Pneumonia	9
<b><i>Porphyromonas gingivalis</i></b> Gingipains-Mediated Degradation of Plasminogen Activator Inhibitor-1 Leads to Delayed Wound Healing Responses in Human Endothelial Cells	9
Ste20-Like Kinase TAOK1 Positively Regulates Antiviral Responses by Controlling the TBK1-IRF3 Signaling Axis	9
Dysregulation of TLR Signaling-Associated Gene Expression in X-linked Agammaglobulinemia: Implications for Correlations Genotype-Phenotype and Disease Expression	9
The Novel Inducer of Innate Immunity HO53 Stimulates Autophagy in Human Airway Epithelial Cells	9
Oxidative stress and chronic inflammation as partners in crime in interstitial cystitis/bladder pain syndrome	9
Development, Characterization, and in vivo Validation of a Humanized C6 Monoclonal Antibody that Inhibits the Membrane Attack Complex	9
Erratum	9
Interference with Lipoprotein Maturation Sensitizes Methicillin-Resistant <b><i>Staphylococcus aureus</i></b> to Human Group IIA-Secreted Phospholipase A<sub>2</sub>	9
Acinetobacter baumannii Clinical Isolates Resist Complement-Mediated Lysis by Inhibiting the Complement Cascade and Improperly Depositing MAC	9
Does Adenosine Triphosphate via Purinergic Receptor Signalling Fuel Pulmonary Fibrosis?	9
Analyzing the Role of Specific Damage-Associated Molecular Patterns-Related Genes in Osteoarthritis and Investigating the Association between β-Amyloid and Apolipoprotein E Isoforms	8
C-Terminal PEGylation Improves SAAP-148 Peptide’s Immunomodulatory Activities	8
<b><i>Candida</i></b> Administration Worsens Neutrophil Extracellular Traps in Renal Ischemia Reperfusion Injury Mice: An Impact of Gut Fungi on Acute Kidney Injury	8
Impact of ATP Synthase Subunit β on TLR Signaling Pathway in Promoting Airway Remodeling and Heterogeneity of Small Airway Epithelial Cells in Chronic Obstructive Pulmonary Disease	8
Procoagulant Activity of Blood and Microvesicles Is Disturbed by Pneumococcal Pneumolysin, Which Interacts with Coagulation Factors	8
Patients Hospitalized with COVID-19 Demonstrate Distinct Plasma Cytokine and Chemokine Concentrations in vivo and TLR-Mediated Cytokine and Chemokine Production in Whole Blood in vitro	8
C4b-Binding Protein and Factor H Attenuate NLRP3 Inflammasome-Mediated Signalling Response during Group A Streptococci Infection in Human Cells	8
CAPN1 Promotes Pseudomonas aeruginosa-Induced Infection by Interacting with TFEB and Inhibiting Autophagy	8
Cathelicidins Induce Toll-Interacting Protein Synthesis to Prevent Apoptosis in Colonic Epithelium	7
Tryptophol Acetate and Tyrosol Acetate, Small-Molecule Metabolites Identified in a Probiotic Mixture, Inhibit Hyperinflammation	7
Pattern-Recognition Receptors and Immunometabolic Reprogramming: What We Know and What to Explore	6
Emerging Roles of cGAS-STING Signaling in Mediating Ocular Inflammation	6
Lectin Pathway Enzyme MASP-2 and Downstream Complement Activation in COVID-19	6
Impact of Changes in Human Airway Epithelial Cellular Composition and Differentiation on SARS-CoV-2 Infection Biology	6
RNA Viruses, Toll-Like Receptors, and Cytokines: The Perfect Storm?	6
Degradation of Ubiquitin-Editing Enzyme A20 following Autophagy Activation Promotes RNF168 Nuclear Translocation and NF-κB Activation in Lupus Nephritis	6
TLR2 or TLR4 Stimulation Induces Transmembrane TNF-Driven Priming in Macrophages Which Results in Improved Clearance of a Subsequent Staphylococcus aureus Infection	6
Identification of Immune Candidate Genes in Post-Sepsis Syndrome: Linking Innate Immunity to Long-Term Autoimmune Responses	6
Role of Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in inflammation and pathogen-associated interactions	5
Ras-Related Protein Rab5a Regulates Complement C5a Receptor Trafficking, Chemotaxis, and Chemokine Secretion in Human Macrophages	5

Prediction of Respiratory Failure and Mortality in COVID-19 Patients Using Long Pentraxin PTX3	5
Development of a C3 Humanized Rat as a New Model for Evaluating Novel C3 Inhibitors	5
Stat3 Regulates Developmental Hematopoiesis and Impacts Myeloid Cell Function via Canonical and Non-Canonical Modalities	5
Ex vivo and in vitro Monocyte Responses Do Not Reflect in vivo Immune Responses and Tolerance	5
TLR2 and NLRP3 Orchestrate Regulatory Roles in Escherichia coli Infection-Induced Septicemia in Mouse Models	4
TLR7 Activation in M-CSF-Dependent Monocyte-Derived Human Macrophages Potentiates Inflammatory Responses and Prompts Neutrophil Recruitment	4
Mesenchymal Stromal Cells Facilitate Neutrophil-Trained Immunity by Reprogramming Hematopoietic Stem Cells	4
Bruton’s Tyrosine Kinase in Neutrophils Is Crucial for Host Defense against <b><i>Klebsiella pneumoniae</i></b>	4
Acknowledgement to Reviewers	4
Erratum	4
Histamine Produced by Gram-Negative Bacteria Impairs Neutrophil’s Antimicrobial Response by Engaging the Histamine 2 Receptor	4
TLR9 dependent activation by inactivated parapoxvirus ovis (iPPVO) in murine bone marrow-derived dendritic cells is associated with specific strain-dependent dendritic cell subsets	4
Formyl Peptide Receptor Type 2 Deficiency in Myeloid Cells Amplifies Sepsis-Induced Cardiac Dysfunction	4