OOIR: Observatory of International Research

Papers

(The TQCC of Engineering in Life Sciences is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Engineering and evaluation of thermostable IsPETase variants for PET degradation	62
Preparation of a pH‐responsive chitosan‐montmorillonite‐nitrogen‐doped carbon quantum dots nanocarrier for attenuating doxorubicin limitations in cancer therapy	61
Recent applications of plant cell culture technology in cosmetics and foods	61
Aptasensors versus immunosensors—Which will prevail?	59
Enzyme immobilization in hydrogels: A perfect liaison for efficient and sustainable biocatalysis	48
Purification and characterization of the receptor‐binding domain of SARS‐CoV‐2 spike protein from Escherichia coli	42
A review of sustainable biodiesel production using biomass derived heterogeneous catalysts	38
Ultra pH‐sensitive detection of total and free prostate‐specific antigen using electrochemical aptasensor based on reduced graphene oxide/gold nanoparticles emphasis on TiO₂/carbon quantum	34
Food ingredients and food made with plant cell and tissue cultures: State‐of‐the art and future trends	32
The pro‐inflammatory response of macrophages regulated by acid degradation products of poly(lactide‐co‐glycolide) nanoparticles	30
Nanofiltration membrane for bio‐separation: Process‐oriented materials innovation	28
Study on dynamic changes of microbial community and lignocellulose transformation mechanism during green waste composting	28
Challenges of influencing cellular morphology by morphology engineering techniques and mechanical induced stress on filamentous pellet systems—A critical review	27
Artificial microbial consortia for bioproduction processes	27
Photobioreactors for cultivation and synthesis: Specifications, challenges, and perspectives	25
Fabrication of Au/Fe₃O₄/RGO based aptasensor for measurement of miRNA‐128, a biomarker for acute lymphoblastic leukemia (ALL)	24
One‐step selective affinity purification and immobilization of His‐tagged enzyme by recyclable magnetic nanoparticles	24
3D printing in biotechnology—An insight into miniaturized and microfluidic systems for applications from cell culture to bioanalytics	24
Efficient phenol degradation by laccase immobilized on functional magnetic nanoparticles in fixed bed reactor under high‐gradient magnetic field	19
Analysis of microbial diversity and succession during Xiaoqu Baijiu fermentation using high‐throughput sequencing technology	18
bletl ‐ A Python package for integrating BioLector microcultivation devices in the Design‐Build‐Test‐Learn cycle	18
pyFOOMB: Python framework for object oriented modeling of bioprocesses	18
Recent advances in microbial capture of hydrogen sulfide from sour gas via sulfur‐oxidizing bacteria	17
Effects and interactions of metal oxides in microparticle‐enhanced cultivation of filamentous microorganisms	17
Assessment of extraction options for a next‐generation biofuel: Recovery of bio‐isobutanol from aqueous solutions	16

Retracted: Comparative molecular docking and molecular‐dynamic simulation of wild‐type‐ and mutant carboxylesterase with BTA‐hydrolase for enhanced binding to plastic	15
An analysis of organism lifelines in an industrial bioreactor using Lattice‐Boltzmann CFD	15
A novel downstream process for highly pure 1,3‐propanediol from an efficient fed‐batch fermentation of raw glycerol by Clostridium pasteurianum	15
New developments in biological phosphorus accessibility and recovery approaches from soil and waste streams	15
Vascular implants – new aspects for in situ tissue engineering	14
Interrogation of the perturbed gut microbiota in gouty arthritis patients through in silico metabolic modeling	14
Separation and purification of plant terpenoids from biotransformation	14
Removal of sugars in wastewater from food production through heterotrophic growth of Galdieria sulphuraria	14
Metabolomic and kinetic investigations on the electricity‐aided production of butanol by Clostridium pasteurianum strains	14
Scaling‐down biopharmaceutical production processes via a single multi‐compartment bioreactor (SMCB)	14
Advances in automated real‐time flow cytometry for monitoring of bioreactor processes	13
A novel twin‐column continuous chromatography approach for separation and enrichment of monoclonal antibody charge variants	13
Characterization of an aerated submerged hollow fiber ultrafiltration device for efficient microalgae harvesting	12
Micro‐aerobic production of isobutanol with engineered Pseudomonas putida	11
Improvement of glycine biosynthesis from one‐carbon compounds and ammonia catalyzed by the glycine cleavage system in vitro	11
Effect of metals on the regulation of acidogenic metabolism enhancing biohydrogen and carboxylic acids production from brewery spent grains: Microbial dynamics and biochemical analysis	11
Development of a 3D‐printed single‐use separation chamber for use in mRNA‐based vaccine production with magnetic microparticles	10
Optimization of a mAb production process with regard to robustness and product quality using quality by design principles	10
Physiologic isolation and expansion of human mesenchymal stem/stromal cells for manufacturing of cell‐based therapy products	10
Monitoring cell productivity for the production of recombinant proteins by flow cytometry: An effective application using the cold capture assay	9
Assessment of microbial activity by CO₂ production during heating oil storage	9
Implementation of QbD strategies in the inoculum expansion of a mAb production process	9
Acceleration of antibacterial activity of curcumin loaded biopolymers against methicillin‐resistant Staphylococcus aureus: Synthesis, optimization, and evaluation	9
Insights into Streptomyces coelicolor A3(2) growth and pigment formation with high‐throughput online monitoring	9
Novel synthetic co‐culture of Acetobacterium woodii and Clostridium drakei using CO₂ and in situ generated H₂ for the production of caproic acid via lactic acid	9
Production of natural colorants by liquid fermentation with Chlorociboria aeruginascens and Laetiporus sulphureus and prospective applications	9
A worldwide survey on the use of animal‐derived materials and reagents in scientific experimentation	9
Streamlining of a synthetic co‐culture towards an individually controllable one‐pot process for polyhydroxyalkanoate production from light and CO₂	9
CRISPRi enables fast growth followed by stable aerobic pyruvate formation in Escherichia coli without auxotrophy	8
Characterization of a novel microfluidic platform for the isolation of rare single cells to enable CTC analysis from head and neck squamous cell carcinoma patients	8
A fluorescence‐based yeast sensor for monitoring acetic acid	8
Purification of a peptide tagged protein via an affinity chromatographic process with underivatized silica	8
Parameter and state estimation of backers yeast cultivation with a gas sensor array and unscented Kalman filter	7
Assessing the growth kinetics and stoichiometry of Escherichia coli at the single‐cell level	7
Upgrading of bio‐separation and bioanalysis using synthetic polymers: Molecularly imprinted polymers (MIPs), cryogels, stimuli‐responsive polymers	7
Pilot scale isolation of exopolysaccharides from Streptococcus thermophilus DGCC7710: Impact of methodical details on macromolecular properties and technofunctionality	7
Improving carotenoid production in recombinant yeast, Saccharomyces cerevisiae, using ultrasound‐irradiated two‐phase extractive fermentation	7
Cultivated meat manufacturing: Technology, trends, and challenges	7
Preparation of lignosulfonate‐based nanofiltration membranes with improved water desalination performance	7
Efficient co‐production of propionic acid and succinic acid by Propionibacterium acidipropionici using membrane separation coupled technology	6
Pseudomonas taiwanensis biofilms for continuous conversion of cyclohexanone in drip flow and rotating bed reactors	6
Removal of heavy metals from industrial wastewater using microbial fuel cell	6
Influence of pH value and salts on the adsorption of lysozyme in mixed‐mode chromatography	6
Applicability of a single‐use bioreactor compared to a glass bioreactor for the fermentation of filamentous fungi and evaluation of the reproducibility of growth in pellet form	6
Enhanced sequestration of carbon dioxide into calcium carbonate using pressure and a carbonic anhydrase from alkaliphilic Coleofasciculus chthonoplastes	6
Purification of pluripotent embryonic stem cells using dielectrophoresis and a flow control system	6
Enrichment of the rebaudioside A concentration in Stevia rebaudiana extract with cyclodextrin glycosyltransferase from Bacillus licheniformis DSM 13	6
Synthesis of ethyl acetate from glucose by Kluyveromyces marxianus, Cyberlindnera jadinii and Wickerhamomyces anomalus depending on the induction mode	6
Machine learning‐based automated fungal cell counting under a complicated background with ilastik and ImageJ	6
Facilitated endospore detection for Bacillus spp. through automated algorithm‐based image processing	5

Patterned vascularization in a directional ice‐templated scaffold of decellularized matrix	5
Synthetic mutualism in engineered E. coli mutant strains as functional basis for microbial production consortia	5
Impact of lipopolysaccharides on cultivation and recombinant protein expression in human embryonal kidney (HEK‐293) cells	5
Three‐liquid‐phase salting‐out extraction of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)‐rich oils from Euphausia superba	5
Modeling multiphase fluid flow, mass transfer, and chemical reactions in bioreactors using large‐eddy simulation	5
Implementing a digital infrastructure for the lab using a central laboratory server and the SiLA2 communication standard	5
FAIR research data management as community approach in bioengineering	5
Evaluation of the mechanical properties and clinical application of nickel–titanium shape memory alloy scaphoid arc nail	5
Optimization of bioprocesses with Brewers’ spent grain and Cellulomonas uda	5
Evaluation of SDS‐coated iron nanostructure on the gene expression of bio surfactant‐producing genes by Pseudomonas aeruginosa	5
Coupling the fermentation and membrane separation process for polyamides monomer cadaverine production from feedstock lysine	5
Stress‐induced increase of monoclonal antibody production in CHO cells	5