OOIR: Observatory of International Research

Papers

(The TQCC of Engineering in Life Sciences is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
	858927920
Engineering and evaluation of thermostable IsPETase variants for PET degradation	50
Preparation of a pH‐responsive chitosan‐montmorillonite‐nitrogen‐doped carbon quantum dots nanocarrier for attenuating doxorubicin limitations in cancer therapy	50
Aptasensors versus immunosensors—Which will prevail?	49
Recent applications of plant cell culture technology in cosmetics and foods	47
Biocatalytic membrane: Go far beyond enzyme immobilization	40
Purification and characterization of the receptor‐binding domain of SARS‐CoV‐2 spike protein from Escherichia coli	38
Enzyme immobilization in hydrogels: A perfect liaison for efficient and sustainable biocatalysis	37
Ultra pH‐sensitive detection of total and free prostate‐specific antigen using electrochemical aptasensor based on reduced graphene oxide/gold nanoparticles emphasis on TiO₂/carbon quantum	28
Investigation of a two‐step device implementing magnetophoresis and dielectrophoresis for separation of circulating tumor cells from blood cells	27
A review of sustainable biodiesel production using biomass derived heterogeneous catalysts	24
Challenges of influencing cellular morphology by morphology engineering techniques and mechanical induced stress on filamentous pellet systems—A critical review	23
Continuous capture of recombinant antibodies by ZnCl₂ precipitation without polyethylene glycol	23
The pro‐inflammatory response of macrophages regulated by acid degradation products of poly(lactide‐co‐glycolide) nanoparticles	22
Food ingredients and food made with plant cell and tissue cultures: State‐of‐the art and future trends	22
Study on dynamic changes of microbial community and lignocellulose transformation mechanism during green waste composting	21
Production of β‐carotene with Dunaliella salina CCAP19/18 at physically simulated outdoor conditions	21
Nanofiltration membrane for bio‐separation: Process‐oriented materials innovation	20
Anti‐EGFR antibody‐drug conjugate for triple‐negative breast cancer therapy	20
One‐step selective affinity purification and immobilization of His‐tagged enzyme by recyclable magnetic nanoparticles	20
Fabrication of Au/Fe₃O₄/RGO based aptasensor for measurement of miRNA‐128, a biomarker for acute lymphoblastic leukemia (ALL)	18
3D printing in biotechnology—An insight into miniaturized and microfluidic systems for applications from cell culture to bioanalytics	17
bletl ‐ A Python package for integrating BioLector microcultivation devices in the Design‐Build‐Test‐Learn cycle	16
Photobioreactors for cultivation and synthesis: Specifications, challenges, and perspectives	16
Tissue engineering in female pelvic floor reconstruction	16

Efficient phenol degradation by laccase immobilized on functional magnetic nanoparticles in fixed bed reactor under high‐gradient magnetic field	15
pyFOOMB: Python framework for object oriented modeling of bioprocesses	15
Metabolomic and kinetic investigations on the electricity‐aided production of butanol by Clostridium pasteurianum strains	14
Artificial microbial consortia for bioproduction processes	14
Kinetic characteristics of long‐term repeated fed‐batch (LtRFb) l‐lactic acid fermentation by a Bacillus coagulans strain	13
Recent advances in microbial capture of hydrogen sulfide from sour gas via sulfur‐oxidizing bacteria	12
Interrogation of the perturbed gut microbiota in gouty arthritis patients through in silico metabolic modeling	12
An analysis of organism lifelines in an industrial bioreactor using Lattice‐Boltzmann CFD	12
Removal of sugars in wastewater from food production through heterotrophic growth of Galdieria sulphuraria	12
Assessment of extraction options for a next‐generation biofuel: Recovery of bio‐isobutanol from aqueous solutions	12
Analysis of microbial diversity and succession during Xiaoqu Baijiu fermentation using high‐throughput sequencing technology	11
Effects and interactions of metal oxides in microparticle‐enhanced cultivation of filamentous microorganisms	11
A novel downstream process for highly pure 1,3‐propanediol from an efficient fed‐batch fermentation of raw glycerol by Clostridium pasteurianum	11
Collective cell migration of fibroblasts is affected by horizontal vibration of the cell culture dish	11
Characterization of an aerated submerged hollow fiber ultrafiltration device for efficient microalgae harvesting	11
Vascular implants – new aspects for in situ tissue engineering	11
Scaling‐down biopharmaceutical production processes via a single multi‐compartment bioreactor (SMCB)	11
New developments in biological phosphorus accessibility and recovery approaches from soil and waste streams	11
Improvement of glycine biosynthesis from one‐carbon compounds and ammonia catalyzed by the glycine cleavage system in vitro	11
Advances in automated real‐time flow cytometry for monitoring of bioreactor processes	11
Characterization and stabilization in process development and product formulation for super large proteinaceous particles	10
A novel twin‐column continuous chromatography approach for separation and enrichment of monoclonal antibody charge variants	10
Separation and purification of plant terpenoids from biotransformation	10
Manipulation of pore structure during manufacture of agarose microspheres for bioseparation	10
Implementation of QbD strategies in the inoculum expansion of a mAb production process	9
Development of a 3D‐printed single‐use separation chamber for use in mRNA‐based vaccine production with magnetic microparticles	9
Preparation and evaluation of amphipathic lipopeptide‐loaded PLGA microspheres as sustained‐release system for AIDS prevention	9
A worldwide survey on the use of animal‐derived materials and reagents in scientific experimentation	9
Elaboration of an algae‐to‐energy system and recovery of water and nutrients from municipal sewage	9
Micro‐aerobic production of isobutanol with engineered Pseudomonas putida	9
Production of natural colorants by liquid fermentation with Chlorociboria aeruginascens and Laetiporus sulphureus and prospective applications	8
Effect of mesoporous silica nanoparticles‐based nano‐fragrance on the central nervous system	8
Optimization of a mAb production process with regard to robustness and product quality using quality by design principles	8
Retracted: Comparative molecular docking and molecular‐dynamic simulation of wild‐type‐ and mutant carboxylesterase with BTA‐hydrolase for enhanced binding to plastic	8
Insights into Streptomyces coelicolor A3(2) growth and pigment formation with high‐throughput online monitoring	8
Novel synthetic co‐culture of Acetobacterium woodii and Clostridium drakei using CO₂ and in situ generated H₂ for the production of caproic acid via lactic acid	7
Development and characterization of a fiber optical fluorescence sensor for the online monitoring of biofilms and their microenvironment	7
Immobilization of an amino acid racemase for application in crystallization‐based chiral resolutions of asparagine monohydrate	7
A fluorescence‐based yeast sensor for monitoring acetic acid	7
Characterization of a novel microfluidic platform for the isolation of rare single cells to enable CTC analysis from head and neck squamous cell carcinoma patients	7
Purification of a peptide tagged protein via an affinity chromatographic process with underivatized silica	7
Monitoring cell productivity for the production of recombinant proteins by flow cytometry: An effective application using the cold capture assay	7
Synthesis of ethyl acetate from glucose by Kluyveromyces marxianus, Cyberlindnera jadinii and Wickerhamomyces anomalus depending on the induction mode	6
Acceleration of antibacterial activity of curcumin loaded biopolymers against methicillin‐resistant Staphylococcus aureus: Synthesis, optimization, and evaluation	6
Influence of pH value and salts on the adsorption of lysozyme in mixed‐mode chromatography	6
Physiologic isolation and expansion of human mesenchymal stem/stromal cells for manufacturing of cell‐based therapy products	6
Assessing the growth kinetics and stoichiometry of Escherichia coli at the single‐cell level	6
Pilot scale isolation of exopolysaccharides from Streptococcus thermophilus DGCC7710: Impact of methodical details on macromolecular properties and technofunctionality	6
CRISPRi enables fast growth followed by stable aerobic pyruvate formation in Escherichia coli without auxotrophy	6
Parameter and state estimation of backers yeast cultivation with a gas sensor array and unscented Kalman filter	6

Investigation of cell line specific responses to pH inhomogeneity and consequences for process design	6
Removal of heavy metals from industrial wastewater using microbial fuel cell	6
Streamlining of a synthetic co‐culture towards an individually controllable one‐pot process for polyhydroxyalkanoate production from light and CO₂	6
High bioreactor production and emulsifying activity of an unusual exopolymer by Chromohalobacter canadensis 28	5
Improving carotenoid production in recombinant yeast, Saccharomyces cerevisiae, using ultrasound‐irradiated two‐phase extractive fermentation	5
Upgrading of bio‐separation and bioanalysis using synthetic polymers: Molecularly imprinted polymers (MIPs), cryogels, stimuli‐responsive polymers	5
Evaluation of SDS‐coated iron nanostructure on the gene expression of bio surfactant‐producing genes by Pseudomonas aeruginosa	5
A vegetable oil–based biopesticide with ovicidal activity against the two‐spotted spider mite, Tetranychus urticae Koch	5
Effect of metals on the regulation of acidogenic metabolism enhancing biohydrogen and carboxylic acids production from brewery spent grains: Microbial dynamics and biochemical analysis	5
Process adapted calibration improves fluorometric pH sensor precision in sophisticated fermentation processes	5
Evaluation of the mechanical properties and clinical application of nickel–titanium shape memory alloy scaphoid arc nail	5
Comparison of l‐tyrosine containing dipeptides reveals maximum ATP availability for l‐prolyl‐l‐tyrosine in CHO cells	5
Machine learning‐based automated fungal cell counting under a complicated background with ilastik and ImageJ	5
Surfactin production in the bioreactor: Emphasis on magnetic nanoparticles application	5
Enrichment of the rebaudioside A concentration in Stevia rebaudiana extract with cyclodextrin glycosyltransferase from Bacillus licheniformis DSM 13	5
Development, characterization, and application of a 2‐Compartment system to investigate the impact of pH inhomogeneities in large‐scale CHO‐based processes	5
Pseudomonas taiwanensis biofilms for continuous conversion of cyclohexanone in drip flow and rotating bed reactors	5
Preparation of lignosulfonate‐based nanofiltration membranes with improved water desalination performance	5
Regulation of pyruvate dehydrogenase complex related to lactate switch in CHO cells	5