OOIR: Observatory of International Research

Papers

(The TQCC of Hereditas is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
A novel chromatin regulator-related immune checkpoint related gene prognostic signature and potential candidate drugs for endometrial cancer patients	39
Insulin-like growth factor binding protein 2: a core biomarker of left ventricular dysfunction in dilated cardiomyopathy	33
Prognostic value of LncRNA PSMA3-AS1 in prostate cancer and its potential regulatory mechanism	26
Identification and validation of USP15 and CUL2 as ubiquitination related biomarker in chronic obstructive pulmonary disease	24
Upregulation of CENPM is associated with poor clinical outcome and suppression of immune profile in clear cell renal cell carcinoma	23
miR-3913-3p promoted the progression of lung adenocarcinoma by regulating STX3 expression	20
NSUN2 restrains gastric cancer cell apoptosis and ferroptosis by promoting the m5C modification of EPYC	20
Cellular plasticity and heterogeneity underlying therapy resistance in 3D cervical cancer models	19
Serum LINC01127 serves as a diagnostic biomarker for sepsis and its predictive value for clinical outcomes	19
Prognostic value of Linc00662/miR-16-5p/FASN in cervical cancer and regulation of tumor progression	17
Integrating bioinformatics analysis, machine learning, and experimental validation to identify pyroptosis-related genes in the diagnosis of sepsis combined with acute liver failure	16
Mediating Mendelian randomization in the proteome identified potential drug targets for obesity-related allergic asthma	14
Extracellular vesicle-derived TP53BP1, CD34, and PBX1 from human peripheral blood serve as potential biomarkers for the assessment and prediction of vascular aging	14
An 8-gene predicting survival model of hepatocellular carcinoma (HCC) related to pyroptosis and cuproptosis	13
Systematic evaluations of forensic effectiveness and genetic structures of two ethnic groups in Northwest China using a self-developed Multi-InDel panel	12
A cuproptosis-related lncRNA signature for predicting prognosis and immunotherapy response of lung adenocarcinoma	12
An artificial neural network model based on autophagy-related genes in childhood systemic lupus erythematosus	11
LncRNA WAC-AS1 expression in human tumors correlates with immune infiltration and affects prognosis	11
In silico and in vitro assessment of TP53, ATM, RAD51, and BAX genes in gastric cancer and their contribution to radiotherapy resistance	10
WMRCA + : a weighted majority rule-based clustering method for cancer subtype prediction using metabolic gene sets	10
Comprehensive analysis to identify pseudogenes/lncRNAs-hsa-miR-200b-3p-COL5A2 network as a prognostic biomarker in gastric cancer	10
Stable populations and Hardy-Weinberg equilibrium	9
Comprehensive evaluations of individual discrimination, kinship analysis, genetic relationship exploration and biogeographic origin prediction in Chinese Dongxiang group by a 60-plex DIP panel	9
E2F1-driven EXOSC10 transcription promotes hepatocellular carcinoma growth and stemness: a potential therapeutic target	9
Cancer-associated fibroblasts and immune escape-related genes serve as biological markers for the prognosis of colorectal cancer	8

STEAP2-associated modulation of PI3K/AKT/mTOR signaling contributes to ginkgetin-induced apoptosis in bladder cancer cells	8
Exploring the anticancer potential of green synthesized Zn/Cu nanocomposites from olive leaves against lung cancer	8
Identification and experimental validation of biomarkers associated with T cell infiltration in psoriasis	8
Structural and functional assessment of TBX20 gene variants in pediatric ventricular septal defect	8
A guide to barley mutants	8
miR-4513 promotes the proliferation and metastasis of non-small cell lung cancer cells by targeting VIPR1	8
MiR-642a-3p increases the risk of postmenopausal osteoporosis and fractures by targeting INO80	8
Identification of FOXK1 and SEMA7A as key genes associated with m6A-related programmed cell death in diabetic retinopathy	8
Regulatory role of ezrin in esophageal cancer progression via the PI3K-AKT signaling pathway	7
The causal effects between low back pain and cerebrospinal fluid metabolites: a two-sample Mendelian randomization study	7
MiR−33 as a novel diagnostic biomarker for distinguishing cholesterol from adenomatous polyps: a case-control study	7
Evaluation of cystatin C and microalbuminuria as predictive markers for hypertension-related renal complications	7
CircCENPM serves as a CeRNA to aggravate nasopharyngeal carcinoma metastasis and stemness via enhancing BMI1	7
Mechanism of LINC00958 in ferroptosis of breast cancer through the SRSF1/GPX4 axis	7
Enhancer-driven transcription of MCM8 by E2F4 promotes ATR pathway activation and glioma stem cell characteristics	7
Susceptibility genes of hyperuricemia and gout	7
Whole blood miRNA expression signatures as predictors of neoadjuvant chemotherapy response in triple-negative breast cancer	6
Genetic overlap between sarcoidosis and lung cancer: a combined in silico and in vitro approach	6
SREBF1, a target gene of multiple sclerosis and coronary heart disease: based on mendelian randomization study	6
Identification and validation of CDC20 and ITCH as ubiquitination related biomarker in idiopathic pulmonary fibrosis	6
Qingjie Fuzheng granules attenuate cancer cachexia by restoring gut microbiota homeostasis and suppressing IL-6/NF-κB signaling in colorectal adenocarcinoma	6
Esketamine induces ferroptosis and suppresses immune evasion in lung adenocarcinoma cells via the hsa_circ_0022392/miR-548b-3p/MAP7 axis	6
RETRACTED ARTICLE: Predictive value of microRNA-133a-3p for early urinary incontinence after radical prostatectomy for prostate cancer and its correlation with rehabilitation effects	6
The causal relationships between gut microbiota and venous thromboembolism: a Mendelian randomization study	6
Diagnostic and prognostic value of miR-146b-5p in acute pancreatitis	6
Mechanisms of Cynarine for treatment of non-alcoholic fatty liver disease based on the integration of network pharmacology, molecular docking and cell experiment	5
A comprehensive analysis of the Cullin family reveals that CUL5 and CUL7 promote colorectal cancer progression and serve as prognostic markers	5
MiR-766-3P promotes degenerative lumbar disc disease by regulating SIRT6 to aggravate the inflammatory response of human nucleus pulposus cells	5
Unraveling the complexities of caffeine: metabolism, genetics, evolution, and health	5
Epithelial zinc finger protein in lung adenocarcinoma: prognostic biomarker with molecular and clinical implications	5
Correction to: Performance comparison of four types of target enrichment baits for exome DNA sequencing	5
Hsa_circ_0006006 is a potential biomarker for prognosis and cisplatin resistance in non-small cell lung cancer	5
Investigating the clinical significance of OAS family genes in breast cancer: an in vitro and in silico study	5
Genetic analysis of albinism caused by compound heterozygous mutations of the OCA2 gene in a Chinese family	5
Exploring the mechanism of dendrobine in treating metabolic associated fatty liver disease based on network pharmacology and experimental validation	5
Ulnar nerve entrapment syndrome: a special case report	5
Integrated multi-omics analysis and machine learning refine molecular subtypes and clinical outcome for hepatocellular carcinoma	5
γ-tocotrienol regulates gastric cancer by targeting notch signaling pathway	5
m6A transferase KIAA1429 mediates the upregulation of LncRNA LINC00968 promoting the progression of gastric cancer cells	5
The novel circFKBP8/miR-432-5p/E2F7 cascade functions as a regulatory network in breast cancer	5
Novel KCNK3 variant in a child with pulmonary arterial hypertension	5
Identification of N6-methyladenosine-associated ferroptosis biomarkers in cervical cancer	5
Revisiting bicoid function: complete inactivation reveals an additional fundamental role in Drosophila egg geometry specification	5
Genetic polymorphism of long non-coding RNA TUG1 and susceptibility to polycystic ovary syndrome: a case-control study	5
Identification of fatty acid metabolism-related genes in the tumor microenvironment of breast cancer by a development and validation of prognostic index signature	5
Fine construction of gene coexpression network analysis using GTOM and RECODE detected a critical module of neuroblastoma stages 4 and 4S	5
The diagnostic and prognostic value of miR-188-5p in intracranial aneurysm (IA) and its potential regulatory mechanism	5
The mechanism of Weiqi decoction treating gastric cancer: a work based on network pharmacology and experimental verification	5
A bioinformatics analysis of the target role of miRNA-431-5p on KLK6 in colorectal cancer	5
Novel variants require established frameworks: emphasizing the role of ISTH diagnostic and classification guidelines in congenital fibrinogen disorders	4

Effects of fourteen essential minerals and vitamins on acute and chronic tubulointerstitial nephritis: a multivariate Mendelian randomization study	4
Recognition and confirmation of key genes associated with nicotinamide metabolism in acute myocardial infarction	4
Screening of ulcerative colitis biomarkers and potential pathways based on weighted gene co-expression network, machine learning and ceRNA hypothesis	4
Why Hereditas leads hereditary cancer awareness now more than ever	4
BHLHE40-mediated RGS16 upregulation: a driver propelling gastric cancer progression via ferroptosis suppression	4
Elevated HMGB1 promotes the malignant progression and contributes to cisplatin resistance of non-small cell lung cancer	4
Decoding mitochondrial stress genes in DCM: towards precision diagnosis and therapy	4
Integrated single-cell and bulk transcriptomic profiling reveals cancer-associated fibroblast heterogeneity in glioblastoma and establishes a clinically actionable prognostic model and preliminary exp	4
Effect of Wendan decoction granules on preventing endolymphatic hydrops and protecting vestibular function in Guinea pigs	4
The diagnostic and prognostic value of LncRNA FAM3D-AS1 expression in nasopharyngeal carcinoma and its effect on tumor progression and cisplatin resistance	4
Serum vitamin C levels and risk of osteoporosis: results from a cross-sectional study and Mendelian randomization analysis	4
Mechanistic evaluation of a traditional herbal decoction in attenuating hepatic fibrosis via Nrf2/GPX4 pathway activation and ferroptosis inhibition	4
Multi-omics integration in deciphering non-small cell lung cancer drug resistance: current status, challenges, and future prospects	4
Genetic insights into therapeutic targets for gout: evidence from a multi-omics mendelian randomization study	4
Yi Gong San inhibits tumor immune escape by sensitizing colorectal cancer stem cells via the NF-κB pathway	4
Erianin inhibits the progression of DDP-resistant lung adenocarcinoma by regulating the Wnt/β-catenin pathway and activating the caspase-3 for apoptosis in vitro and in vivo	4
β-Nicotinamide mononucleotide alleviates Alcohol-Induced liver injury in a mouse model through activation of NAD+/SIRT1 signaling pathways	4
A novel risk model consisting of nine platelet-related gene signatures for predicting prognosis, immune features and drug sensitivity in glioma	4
Association between chronic obstructive pulmonary disease and osteoporosis: Mendelian randomization combined with bibliometric analysis	4
Development and implementation of an etiology-based diagnostic framework for acute abdominal pain in emergency settings	4
Disulfidptosis classification of pancreatic carcinoma reveals correlation with clinical prognosis and immune profile	4
Suppression of circ_0091761 ameliorates acute myocardial infarction-induced endothelial injury through regulation of miR-1278	4
Screening and analysis of programmed cell death related genes and targeted drugs in sepsis	4
Performance of a self-developed panel for biogeographic ancestry inference and dissection of the genetic background of three Tibetan groups	4
Identification and validation of energy metabolism-related genes in diabetic kidney disease through integrated bioinformatics and in vivo analysis	4
Extracellular matrix-growth factor signalling drives the oncogenic mir-125b-2/UCK2 axis in hepatocellular carcinoma	4
Role of necroptosis and immune infiltration in essential thrombocytosis	4
Circular RNAs: novel noncoding players in male infertility	4
Investigation of the molecular mechanism of Xiaoluo Wan in thyroid-associated ophthalmopathy: network analysis and in vivo study	4
Optical genome mapping of a complex structural rearrangement family line on chromosome 18	4
EZH2 regulates pancreatic cancer cells through E2F1, GLI1, CDK3, and Mcm4	4
Managing gastrointestinal involvement in cutaneomucosal venous malformation: safety and efficacy of endoscopic sclerotherapy	4
Acetylation proteomics and metabolomics analyses reveal the involvement of starch synthase undergoing acetylation modification during UV-B stress resistance in Rhododendron Chrysanthum Pall	4
PTTG1 regulates the TGF-β/Smad pathway to promote the growth and metastasis of gastric cancer cells	4
LncRNA RASAL2-AS1 serves as a potential biomarker for prognosis and regulates cellular processes via the miR-590-5p/PDCD5 axis and Wnt/β-catenin pathway in cervical cancer	4
Mechanistic insights into CDCA gene family-mediated glioblastoma progression: implications for diagnosis, prognosis, and therapeutic targeting	4
Coptisine regulates PI3K/AKT pathway to block bladder cancer progression: a study based on network pharmacology, in vitro and in vivo assays	4
Correlation between gut microbiota characteristics and non-small cell lung cancer based on macrogenomics sequencing	3
Understanding the contemporary high obesity rate from an evolutionary genetic perspective	3
A novel molecular subtypes and risk model based on inflammatory response-related lncrnas for bladder cancer	3
miR-671-5p as a diagnostic biomarker and therapeutic target in periodontitis via THBS1 regulation	3
Inhibition of microRNA-660-5p decreases breast cancer progression through direct targeting of TMEM41B	3
Shenling Baizhu San attenuates testicular spermatogenic dysfunction in hyperuricemic mice via dual modulation of MAPK/NF-κB and NLRP3 inflammasome pathways	3
Enhancer-based gene therapy: a new path for precision medicine	3
RNA binding protein ILF3 increases CEP55 mRNA stability to enhance malignant potential of breast cancer cells and suppress ferroptosis	3
Jianpi Qutan Decoction improves hepatic lipid metabolism in atherosclerosis mice via PPARα-CPT1α pathway regulation	3
Programmed death 1 inhibitor combined with radiotherapy decreases epidermal growth factor receptor expression in breast cancer	3
Ginsenoside Rg1 delays the senescence of adipose-derived stem cells: network pharmacology and experimental validation	3
Zebrafish nampt-a mutants are viable despite perturbed primitive hematopoiesis	3
RBM15 mediates m6A methylation modification of FOSB mRNA to promote dysfunction of trophoblast cells-a potential link to preeclampsia	3
Efficacy of red ointment in wound cavity repair following non-puerperal mastitis debridement	3
Correction: Identification and functional characterization of key biomarkers in diffuse large B-cell lymphoma: emphasis on STYX as a prognostic marker and therapeutic target	3
Multi-Omics analysis and in vitro validation reveal diagnostic and therapeutic roles of novel hub genes in ovarian cancer	3
Identification and validation of autophagy-related genes in Kawasaki disease	3
Mutations in the acetolactate synthase (ALS) enzyme affect shattercane (Sorghum bicolor) response to ALS-inhibiting herbicides	3
Knockdown of IGF2BP2 overcomes cisplatin-resistance in lung cancer through downregulating Spon2 gene	3
WDR62 affects the progression of ovarian cancer by regulating the cell cycle	3
Integrative multi-omics and single-cell transcriptomics reveal ARHGEF12 driving chemoresistance in bladder cancer	3
Predicting the therapeutic role and potential mechanisms of Indole-3-acetic acid in diminished ovarian reserve based on network pharmacology and molecular docking	3
Identification of immune-related mitochondrial metabolic disorder genes in septic shock using bioinformatics and machine learning	3
Analysis of spermidine’s effect on coronary heart disease risk using bidirectional Mendelian randomization and LC-MS/MS	3
Analysis of the biological mechanism of Gurigumu-13 in the treatment of non-alcoholic fatty liver disease based on network pharmacology	3
Editorial: Celebration of DNA Day	3
Uncovering new MicroRNAs linked to acute pancreatitis: zeroing in on the protective effect	3
Global research trends in non-coding RNA and intestinal epithelial homeostasis: an integrated bibliometric analysis (2007–2024)	3
Characterization of key genes and immune cell infiltration associated with endometriosis through integrating bioinformatics and experimental analyses	3
TFAP2A promotes NSCLC malignant progression by enhancing AOC1 transcription	3
Protective effect of Saikosaponin D modulating endoplasmic reticulum stress mediated by TLR4/MyD88/NF-κB/NLRP3 pathway on cholestatic liver injury	3
Metabolic heterogeneity and survival outcomes in papillary renal cell carcinoma: insights from multi-datasets and machine learning analyses	3
Transformation and gene-disruption in the apple-pathogen, Neonectria ditissima	3
Expression of long non-coding RNA NNT-AS1 in children with severe pneumonia and its effect on lipopolysaccharide-induced human embryonic lung fibroblast injury	3
Development and validation of a succinylation-related prognostic model for esophageal squamous cell carcinoma based on multi-omics bioinformatics analysis	3
Daidzein and puerarin synergistically suppress gastric cancer proliferation via STAT3/FAK pathway Inhibition	3