OOIR: Observatory of International Research

Papers

(The TQCC of Hereditas is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
A novel chromatin regulator-related immune checkpoint related gene prognostic signature and potential candidate drugs for endometrial cancer patients	37
Prognostic value of LncRNA PSMA3-AS1 in prostate cancer and its potential regulatory mechanism	29
miR-3913-3p promoted the progression of lung adenocarcinoma by regulating STX3 expression	26
Cellular plasticity and heterogeneity underlying therapy resistance in 3D cervical cancer models	22
Serum LINC01127 serves as a diagnostic biomarker for sepsis and its predictive value for clinical outcomes	21
Upregulation of CENPM is associated with poor clinical outcome and suppression of immune profile in clear cell renal cell carcinoma	21
Identification and validation of USP15 and CUL2 as ubiquitination related biomarker in chronic obstructive pulmonary disease	18
Insulin-like growth factor binding protein 2: a core biomarker of left ventricular dysfunction in dilated cardiomyopathy	18
NSUN2 restrains gastric cancer cell apoptosis and ferroptosis by promoting the m5C modification of EPYC	17
Prognostic value of Linc00662/miR-16-5p/FASN in cervical cancer and regulation of tumor progression	16
Integrating bioinformatics analysis, machine learning, and experimental validation to identify pyroptosis-related genes in the diagnosis of sepsis combined with acute liver failure	16
Mediating Mendelian randomization in the proteome identified potential drug targets for obesity-related allergic asthma	15
Extracellular vesicle-derived TP53BP1, CD34, and PBX1 from human peripheral blood serve as potential biomarkers for the assessment and prediction of vascular aging	15
E2F1-driven EXOSC10 transcription promotes hepatocellular carcinoma growth and stemness: a potential therapeutic target	14
An 8-gene predicting survival model of hepatocellular carcinoma (HCC) related to pyroptosis and cuproptosis	14
Systematic evaluations of forensic effectiveness and genetic structures of two ethnic groups in Northwest China using a self-developed Multi-InDel panel	13
WMRCA + : a weighted majority rule-based clustering method for cancer subtype prediction using metabolic gene sets	12
Comprehensive evaluations of individual discrimination, kinship analysis, genetic relationship exploration and biogeographic origin prediction in Chinese Dongxiang group by a 60-plex DIP panel	12
LncRNA WAC-AS1 expression in human tumors correlates with immune infiltration and affects prognosis	11
In silico and in vitro assessment of TP53, ATM, RAD51, and BAX genes in gastric cancer and their contribution to radiotherapy resistance	10
Cancer-associated fibroblasts and immune escape-related genes serve as biological markers for the prognosis of colorectal cancer	10
An artificial neural network model based on autophagy-related genes in childhood systemic lupus erythematosus	10
A cuproptosis-related lncRNA signature for predicting prognosis and immunotherapy response of lung adenocarcinoma	9
Comprehensive analysis to identify pseudogenes/lncRNAs-hsa-miR-200b-3p-COL5A2 network as a prognostic biomarker in gastric cancer	9
Regulatory role of ezrin in esophageal cancer progression via the PI3K-AKT signaling pathway	8

Stable populations and Hardy-Weinberg equilibrium	8
Evaluation of cystatin C and microalbuminuria as predictive markers for hypertension-related renal complications	8
Structural and functional assessment of TBX20 gene variants in pediatric ventricular septal defect	8
The causal effects between low back pain and cerebrospinal fluid metabolites: a two-sample Mendelian randomization study	8
CircCENPM serves as a CeRNA to aggravate nasopharyngeal carcinoma metastasis and stemness via enhancing BMI1	8
Enhancer-driven transcription of MCM8 by E2F4 promotes ATR pathway activation and glioma stem cell characteristics	7
Mechanism of LINC00958 in ferroptosis of breast cancer through the SRSF1/GPX4 axis	7
SREBF1, a target gene of multiple sclerosis and coronary heart disease: based on mendelian randomization study	7
Exploring the anticancer potential of green synthesized Zn/Cu nanocomposites from olive leaves against lung cancer	7
MiR−33 as a novel diagnostic biomarker for distinguishing cholesterol from adenomatous polyps: a case-control study	7
Susceptibility genes of hyperuricemia and gout	6
Diagnostic and prognostic value of miR-146b-5p in acute pancreatitis	6
RETRACTED ARTICLE: Predictive value of microRNA-133a-3p for early urinary incontinence after radical prostatectomy for prostate cancer and its correlation with rehabilitation effects	6
Revisiting bicoid function: complete inactivation reveals an additional fundamental role in Drosophila egg geometry specification	6
Genetic polymorphism of long non-coding RNA TUG1 and susceptibility to polycystic ovary syndrome: a case-control study	6
A guide to barley mutants	6
Identification and validation of CDC20 and ITCH as ubiquitination related biomarker in idiopathic pulmonary fibrosis	6
Mechanisms of Cynarine for treatment of non-alcoholic fatty liver disease based on the integration of network pharmacology, molecular docking and cell experiment	6
Unraveling the complexities of caffeine: metabolism, genetics, evolution, and health	6
Genetic overlap between sarcoidosis and lung cancer: a combined in silico and in vitro approach	6
Qingjie Fuzheng granules attenuate cancer cachexia by restoring gut microbiota homeostasis and suppressing IL-6/NF-κB signaling in colorectal adenocarcinoma	6
Ulnar nerve entrapment syndrome: a special case report	6
Genetic analysis of albinism caused by compound heterozygous mutations of the OCA2 gene in a Chinese family	6
Fine construction of gene coexpression network analysis using GTOM and RECODE detected a critical module of neuroblastoma stages 4 and 4S	5
The mechanism of Weiqi decoction treating gastric cancer: a work based on network pharmacology and experimental verification	5
The diagnostic and prognostic value of miR-188-5p in intracranial aneurysm (IA) and its potential regulatory mechanism	5
A comprehensive analysis of the Cullin family reveals that CUL5 and CUL7 promote colorectal cancer progression and serve as prognostic markers	5
Exploring the mechanism of dendrobine in treating metabolic associated fatty liver disease based on network pharmacology and experimental validation	5
γ-tocotrienol regulates gastric cancer by targeting notch signaling pathway	5
m6A transferase KIAA1429 mediates the upregulation of LncRNA LINC00968 promoting the progression of gastric cancer cells	5
Correction to: Performance comparison of four types of target enrichment baits for exome DNA sequencing	5
A bioinformatics analysis of the target role of miRNA-431-5p on KLK6 in colorectal cancer	5
Integrated multi-omics analysis and machine learning refine molecular subtypes and clinical outcome for hepatocellular carcinoma	5
Identification of fatty acid metabolism-related genes in the tumor microenvironment of breast cancer by a development and validation of prognostic index signature	5
Epithelial zinc finger protein in lung adenocarcinoma: prognostic biomarker with molecular and clinical implications	5
The novel circFKBP8/miR-432-5p/E2F7 cascade functions as a regulatory network in breast cancer	5
Novel KCNK3 variant in a child with pulmonary arterial hypertension	5
Identification of N6-methyladenosine-associated ferroptosis biomarkers in cervical cancer	5
The causal relationships between gut microbiota and venous thromboembolism: a Mendelian randomization study	5
Erianin inhibits the progression of DDP-resistant lung adenocarcinoma by regulating the Wnt/β-catenin pathway and activating the caspase-3 for apoptosis in vitro and in vivo	4
BHLHE40-mediated RGS16 upregulation: a driver propelling gastric cancer progression via ferroptosis suppression	4
Association between chronic obstructive pulmonary disease and osteoporosis: Mendelian randomization combined with bibliometric analysis	4
Genetic insights into therapeutic targets for gout: evidence from a multi-omics mendelian randomization study	4
Identification and validation of energy metabolism-related genes in diabetic kidney disease through integrated bioinformatics and in vivo analysis	4
A novel risk model consisting of nine platelet-related gene signatures for predicting prognosis, immune features and drug sensitivity in glioma	4
Disulfidptosis classification of pancreatic carcinoma reveals correlation with clinical prognosis and immune profile	4
Role of necroptosis and immune infiltration in essential thrombocytosis	4
Serum vitamin C levels and risk of osteoporosis: results from a cross-sectional study and Mendelian randomization analysis	4
Circular RNAs: novel noncoding players in male infertility	4
Why Hereditas leads hereditary cancer awareness now more than ever	4

Investigation of the molecular mechanism of Xiaoluo Wan in thyroid-associated ophthalmopathy: network analysis and in vivo study	4
Investigating the clinical significance of OAS family genes in breast cancer: an in vitro and in silico study	4
Screening of ulcerative colitis biomarkers and potential pathways based on weighted gene co-expression network, machine learning and ceRNA hypothesis	4
Effects of fourteen essential minerals and vitamins on acute and chronic tubulointerstitial nephritis: a multivariate Mendelian randomization study	4
Performance of a self-developed panel for biogeographic ancestry inference and dissection of the genetic background of three Tibetan groups	4
Suppression of circ_0091761 ameliorates acute myocardial infarction-induced endothelial injury through regulation of miR-1278	4
PTTG1 regulates the TGF-β/Smad pathway to promote the growth and metastasis of gastric cancer cells	4
Yi Gong San inhibits tumor immune escape by sensitizing colorectal cancer stem cells via the NF-κB pathway	4
EZH2 regulates pancreatic cancer cells through E2F1, GLI1, CDK3, and Mcm4	4
Optical genome mapping of a complex structural rearrangement family line on chromosome 18	4
β-Nicotinamide mononucleotide alleviates Alcohol-Induced liver injury in a mouse model through activation of NAD+/SIRT1 signaling pathways	4
Hsa_circ_0006006 is a potential biomarker for prognosis and cisplatin resistance in non-small cell lung cancer	4
Decoding mitochondrial stress genes in DCM: towards precision diagnosis and therapy	4
Coptisine regulates PI3K/AKT pathway to block bladder cancer progression: a study based on network pharmacology, in vitro and in vivo assays	4
Integrated single-cell and bulk transcriptomic profiling reveals cancer-associated fibroblast heterogeneity in glioblastoma and establishes a clinically actionable prognostic model and preliminary exp	4
Effect of Wendan decoction granules on preventing endolymphatic hydrops and protecting vestibular function in Guinea pigs	4
Managing gastrointestinal involvement in cutaneomucosal venous malformation: safety and efficacy of endoscopic sclerotherapy	4
Multi-omics integration in deciphering non-small cell lung cancer drug resistance: current status, challenges, and future prospects	4
Recognition and confirmation of key genes associated with nicotinamide metabolism in acute myocardial infarction	4
Screening and analysis of programmed cell death related genes and targeted drugs in sepsis	3
Identification of biomarkers, immune infiltration landscape, and treatment targets of ischemia–reperfusion acute kidney injury at an early stage by bioinformatics methods	3
Elevated HMGB1 promotes the malignant progression and contributes to cisplatin resistance of non-small cell lung cancer	3
Uncovering new MicroRNAs linked to acute pancreatitis: zeroing in on the protective effect	3
Understanding the contemporary high obesity rate from an evolutionary genetic perspective	3
Jianpi Qutan Decoction improves hepatic lipid metabolism in atherosclerosis mice via PPARα-CPT1α pathway regulation	3
Correction: Identification and functional characterization of key biomarkers in diffuse large B-cell lymphoma: emphasis on STYX as a prognostic marker and therapeutic target	3
Transformation and gene-disruption in the apple-pathogen, Neonectria ditissima	3
Enhancer-based gene therapy: a new path for precision medicine	3
Mutations in the acetolactate synthase (ALS) enzyme affect shattercane (Sorghum bicolor) response to ALS-inhibiting herbicides	3
Metabolic heterogeneity and survival outcomes in papillary renal cell carcinoma: insights from multi-datasets and machine learning analyses	3
Mechanistic insights into CDCA gene family-mediated glioblastoma progression: implications for diagnosis, prognosis, and therapeutic targeting	3
Acetylation proteomics and metabolomics analyses reveal the involvement of starch synthase undergoing acetylation modification during UV-B stress resistance in Rhododendron Chrysanthum Pall	3
Extracellular matrix-growth factor signalling drives the oncogenic mir-125b-2/UCK2 axis in hepatocellular carcinoma	3
Development and implementation of an etiology-based diagnostic framework for acute abdominal pain in emergency settings	3
Knockdown of IGF2BP2 overcomes cisplatin-resistance in lung cancer through downregulating Spon2 gene	3
Arecoline promotes proliferation and migration of human HepG2 cells through activation of the PI3K/AKT/mTOR pathway	3
Multi-Omics analysis and in vitro validation reveal diagnostic and therapeutic roles of novel hub genes in ovarian cancer	3
Characterization of key genes and immune cell infiltration associated with endometriosis through integrating bioinformatics and experimental analyses	3
Mutation update of SERPING1 related to hereditary angioedema in the Chinese population	3
miR-671-5p as a diagnostic biomarker and therapeutic target in periodontitis via THBS1 regulation	3
Mechanistic evaluation of a traditional herbal decoction in attenuating hepatic fibrosis via Nrf2/GPX4 pathway activation and ferroptosis inhibition	3
WDR62 affects the progression of ovarian cancer by regulating the cell cycle	3
The diagnostic and prognostic value of LncRNA FAM3D-AS1 expression in nasopharyngeal carcinoma and its effect on tumor progression and cisplatin resistance	3
Trimeric complexes of Antp-TBP with TFIIEβ or Exd modulate transcriptional activity	3
Novel variants require established frameworks: emphasizing the role of ISTH diagnostic and classification guidelines in congenital fibrinogen disorders	3
TFAP2A promotes NSCLC malignant progression by enhancing AOC1 transcription	3
Global research trends in non-coding RNA and intestinal epithelial homeostasis: an integrated bibliometric analysis (2007–2024)	3
Shenling Baizhu San attenuates testicular spermatogenic dysfunction in hyperuricemic mice via dual modulation of MAPK/NF-κB and NLRP3 inflammasome pathways	3
Programmed death 1 inhibitor combined with radiotherapy decreases epidermal growth factor receptor expression in breast cancer	3
Protective effect of Saikosaponin D modulating endoplasmic reticulum stress mediated by TLR4/MyD88/NF-κB/NLRP3 pathway on cholestatic liver injury	3
RNA binding protein ILF3 increases CEP55 mRNA stability to enhance malignant potential of breast cancer cells and suppress ferroptosis	3
Integrative multi-omics and single-cell transcriptomics reveal ARHGEF12 driving chemoresistance in bladder cancer	3