OOIR: Observatory of International Research

Papers

(The TQCC of Hereditas is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)

Article	Citations
Insulin-like growth factor binding protein 2: a core biomarker of left ventricular dysfunction in dilated cardiomyopathy	41
A novel chromatin regulator-related immune checkpoint related gene prognostic signature and potential candidate drugs for endometrial cancer patients	29
Prognostic value of Linc00662/miR-16-5p/FASN in cervical cancer and regulation of tumor progression	28
Integrating bioinformatics analysis, machine learning, and experimental validation to identify pyroptosis-related genes in the diagnosis of sepsis combined with acute liver failure	22
Upregulation of CENPM is associated with poor clinical outcome and suppression of immune profile in clear cell renal cell carcinoma	22
Prognostic value of LncRNA PSMA3-AS1 in prostate cancer and its potential regulatory mechanism	21
Identification and validation of USP15 and CUL2 as ubiquitination related biomarker in chronic obstructive pulmonary disease	19
Mediating Mendelian randomization in the proteome identified potential drug targets for obesity-related allergic asthma	18
Extracellular vesicle-derived TP53BP1, CD34, and PBX1 from human peripheral blood serve as potential biomarkers for the assessment and prediction of vascular aging	18
E2F1-driven EXOSC10 transcription promotes hepatocellular carcinoma growth and stemness: a potential therapeutic target	17
Systematic evaluations of forensic effectiveness and genetic structures of two ethnic groups in Northwest China using a self-developed Multi-InDel panel	16
An 8-gene predicting survival model of hepatocellular carcinoma (HCC) related to pyroptosis and cuproptosis	16
Comprehensive evaluations of individual discrimination, kinship analysis, genetic relationship exploration and biogeographic origin prediction in Chinese Dongxiang group by a 60-plex DIP panel	14
A cuproptosis-related lncRNA signature for predicting prognosis and immunotherapy response of lung adenocarcinoma	13
An artificial neural network model based on autophagy-related genes in childhood systemic lupus erythematosus	11
LncRNA WAC-AS1 expression in human tumors correlates with immune infiltration and affects prognosis	11
Cell-free DNA from plasma as a promising alternative for detection of gene mutations in patients with Maffucci syndrome	11
Gene expression trend changes in breast cancer populations over two decades: insights from The Cancer Genome Atlas database	10
Comprehensive analysis to identify pseudogenes/lncRNAs-hsa-miR-200b-3p-COL5A2 network as a prognostic biomarker in gastric cancer	10
WMRCA + : a weighted majority rule-based clustering method for cancer subtype prediction using metabolic gene sets	10
Enhancer analysis of the Drosophila zinc finger transcription factor Earmuff by gene targeting	9
Stable populations and Hardy-Weinberg equilibrium	9
In silico and in vitro assessment of TP53, ATM, RAD51, and BAX genes in gastric cancer and their contribution to radiotherapy resistance	9
The causal effects between low back pain and cerebrospinal fluid metabolites: a two-sample Mendelian randomization study	8
RNA-Seq based transcriptome analysis in oral lichen planus	8

Structural and functional assessment of TBX20 gene variants in pediatric ventricular septal defect	8
SREBF1, a target gene of multiple sclerosis and coronary heart disease: based on mendelian randomization study	8
Susceptibility genes of hyperuricemia and gout	8
A guide to barley mutants	7
Enhancer-driven transcription of MCM8 by E2F4 promotes ATR pathway activation and glioma stem cell characteristics	7
CircCENPM serves as a CeRNA to aggravate nasopharyngeal carcinoma metastasis and stemness via enhancing BMI1	7
MiR−33 as a novel diagnostic biomarker for distinguishing cholesterol from adenomatous polyps: a case-control study	7
Exploring the anticancer potential of green synthesized Zn/Cu nanocomposites from olive leaves against lung cancer	7
Regulatory role of ezrin in esophageal cancer progression via the PI3K-AKT signaling pathway	6
Qingjie Fuzheng granules attenuate cancer cachexia by restoring gut microbiota homeostasis and suppressing IL-6/NF-κB signaling in colorectal adenocarcinoma	6
Mechanism of LINC00958 in ferroptosis of breast cancer through the SRSF1/GPX4 axis	6
Identification and validation of CDC20 and ITCH as ubiquitination related biomarker in idiopathic pulmonary fibrosis	6
Predictive value of microRNA-133a-3p for early urinary incontinence after radical prostatectomy for prostate cancer and its correlation with rehabilitation effects	6
Diagnostic and prognostic value of miR-146b-5p in acute pancreatitis	6
Exploring the mechanism of dendrobine in treating metabolic associated fatty liver disease based on network pharmacology and experimental validation	5
Genetic analysis of albinism caused by compound heterozygous mutations of the OCA2 gene in a Chinese family	5
Association between chronic obstructive pulmonary disease and osteoporosis: Mendelian randomization combined with bibliometric analysis	5
Genetic overlap between sarcoidosis and lung cancer: a combined in silico and in vitro approach	5
The causal relationships between gut microbiota and venous thromboembolism: a Mendelian randomization study	5
Mechanisms of Cynarine for treatment of non-alcoholic fatty liver disease based on the integration of network pharmacology, molecular docking and cell experiment	5
β-Nicotinamide mononucleotide alleviates Alcohol-Induced liver injury in a mouse model through activation of NAD+/SIRT1 signaling pathways	5
Integrated multi-omics analysis and machine learning refine molecular subtypes and clinical outcome for hepatocellular carcinoma	5
Ulnar nerve entrapment syndrome: a special case report	5
Revisiting bicoid function: complete inactivation reveals an additional fundamental role in Drosophila egg geometry specification	5
Identification of N6-methyladenosine-associated ferroptosis biomarkers in cervical cancer	5
Hsa_circ_0006006 is a potential biomarker for prognosis and cisplatin resistance in non-small cell lung cancer	4
Investigating the clinical significance of OAS family genes in breast cancer: an in vitro and in silico study	4
m6A transferase KIAA1429 mediates the upregulation of LncRNA LINC00968 promoting the progression of gastric cancer cells	4
A bioinformatics analysis of the target role of miRNA-431-5p on KLK6 in colorectal cancer	4
Genetic insights into therapeutic targets for gout: evidence from a multi-omics mendelian randomization study	4
Erianin inhibits the progression of DDP-resistant lung adenocarcinoma by regulating the Wnt/β-catenin pathway and activating the caspase-3 for apoptosis in vitro and in vivo	4
Investigation of the molecular mechanism of Xiaoluo Wan in thyroid-associated ophthalmopathy: network analysis and in vivo study	4
Fine construction of gene coexpression network analysis using GTOM and RECODE detected a critical module of neuroblastoma stages 4 and 4S	4
Identification of fatty acid metabolism-related genes in the tumor microenvironment of breast cancer by a development and validation of prognostic index signature	4
The novel circFKBP8/miR-432-5p/E2F7 cascade functions as a regulatory network in breast cancer	4
BHLHE40-mediated RGS16 upregulation: a driver propelling gastric cancer progression via ferroptosis suppression	4
A novel risk model consisting of nine platelet-related gene signatures for predicting prognosis, immune features and drug sensitivity in glioma	4
Circular RNAs: novel noncoding players in male infertility	4
Epithelial zinc finger protein in lung adenocarcinoma: prognostic biomarker with molecular and clinical implications	4
Correction to: Performance comparison of four types of target enrichment baits for exome DNA sequencing	4
The mechanism of Weiqi decoction treating gastric cancer: a work based on network pharmacology and experimental verification	4
γ-tocotrienol regulates gastric cancer by targeting notch signaling pathway	4
Screening of ulcerative colitis biomarkers and potential pathways based on weighted gene co-expression network, machine learning and ceRNA hypothesis	4
Decoding mitochondrial stress genes in DCM: towards precision diagnosis and therapy	4
Why Hereditas leads hereditary cancer awareness now more than ever	3
Yi Gong San inhibits tumor immune escape by sensitizing colorectal cancer stem cells via the NF-κB pathway	3
Managing gastrointestinal involvement in cutaneomucosal venous malformation: safety and efficacy of endoscopic sclerotherapy	3
Trimeric complexes of Antp-TBP with TFIIEβ or Exd modulate transcriptional activity	3
Development and implementation of an etiology-based diagnostic framework for acute abdominal pain in emergency settings	3
Role of necroptosis and immune infiltration in essential thrombocytosis	3

Identification of biomarkers, immune infiltration landscape, and treatment targets of ischemia–reperfusion acute kidney injury at an early stage by bioinformatics methods	3
Integrated single-cell and bulk transcriptomic profiling reveals cancer-associated fibroblast heterogeneity in glioblastoma and establishes a clinically actionable prognostic model and preliminary exp	3
Serum vitamin C levels and risk of osteoporosis: results from a cross-sectional study and Mendelian randomization analysis	3
Acetylation proteomics and metabolomics analyses reveal the involvement of starch synthase undergoing acetylation modification during UV-B stress resistance in Rhododendron Chrysanthum Pall	3
Suppression of circ_0091761 ameliorates acute myocardial infarction-induced endothelial injury through regulation of miR-1278	3
Novel variants require established frameworks: emphasizing the role of ISTH diagnostic and classification guidelines in congenital fibrinogen disorders	3
Effects of fourteen essential minerals and vitamins on acute and chronic tubulointerstitial nephritis: a multivariate Mendelian randomization study	3
Disulfidptosis classification of pancreatic carcinoma reveals correlation with clinical prognosis and immune profile	3
Elevated HMGB1 promotes the malignant progression and contributes to cisplatin resistance of non-small cell lung cancer	3
Effect of Wendan decoction granules on preventing endolymphatic hydrops and protecting vestibular function in Guinea pigs	3
WDR62 affects the progression of ovarian cancer by regulating the cell cycle	3
EZH2 regulates pancreatic cancer cells through E2F1, GLI1, CDK3, and Mcm4	3
Mechanistic insights into CDCA gene family-mediated glioblastoma progression: implications for diagnosis, prognosis, and therapeutic targeting	2
Protein content and HvNAM alleles in Nordic barley (Hordeum vulgare) during a century of breeding	2
A novel mutation of CTC1 leads to telomere shortening in a chinese family with interstitial lung disease	2
Development and validation of an RBP gene signature for prognosis prediction in colorectal cancer based on WGCNA	2
TGF-β1/SMOC2/AKT and ERK axis regulates proliferation, migration, and fibroblast to myofibroblast transformation in lung fibroblast, contributing with the asthma progression	2
Zebrafish nampt-a mutants are viable despite perturbed primitive hematopoiesis	2
Metabolic heterogeneity and survival outcomes in papillary renal cell carcinoma: insights from multi-datasets and machine learning analyses	2
Inhibition of microRNA-660-5p decreases breast cancer progression through direct targeting of TMEM41B	2
Identification and validation of autophagy-related genes in Kawasaki disease	2
Identification of immune-related mitochondrial metabolic disorder genes in septic shock using bioinformatics and machine learning	2
Identification of crucial genes involved in pathogenesis of regional weakening of the aortic wall	2
Shenling Baizhu San attenuates testicular spermatogenic dysfunction in hyperuricemic mice via dual modulation of MAPK/NF-κB and NLRP3 inflammasome pathways	2
TFAP2A promotes NSCLC malignant progression by enhancing AOC1 transcription	2
Correlation between gut microbiota characteristics and non-small cell lung cancer based on macrogenomics sequencing	2
Mutations in the acetolactate synthase (ALS) enzyme affect shattercane (Sorghum bicolor) response to ALS-inhibiting herbicides	2
Mechanistic evaluation of a traditional herbal decoction in attenuating hepatic fibrosis via Nrf2/GPX4 pathway activation and ferroptosis inhibition	2
Screening and analysis of programmed cell death related genes and targeted drugs in sepsis	2
Multi-Omics analysis and in vitro validation reveal diagnostic and therapeutic roles of novel hub genes in ovarian cancer	2
The potential role of biomarkers CD28 and PF4 in the pathogenesis of idiopathic pulmonary fibrosis and their impact on the prognosis: an immune microenvironment analysis	2
Programmed death 1 inhibitor combined with radiotherapy decreases epidermal growth factor receptor expression in breast cancer	2
Daidzein and puerarin synergistically suppress gastric cancer proliferation via STAT3/FAK pathway Inhibition	2
Correction: Identification and functional characterization of key biomarkers in diffuse large B-cell lymphoma: emphasis on STYX as a prognostic marker and therapeutic target	2
Efficacy of red ointment in wound cavity repair following non-puerperal mastitis debridement	2
Transformation and gene-disruption in the apple-pathogen, Neonectria ditissima	2
Editorial: Celebration of DNA Day	2
Arecoline promotes proliferation and migration of human HepG2 cells through activation of the PI3K/AKT/mTOR pathway	2
Mutation update of SERPING1 related to hereditary angioedema in the Chinese population	2
RNA binding protein ILF3 increases CEP55 mRNA stability to enhance malignant potential of breast cancer cells and suppress ferroptosis	2
The diagnostic and prognostic value of LncRNA FAM3D-AS1 expression in nasopharyngeal carcinoma and its effect on tumor progression and cisplatin resistance	2
miR-671-5p as a diagnostic biomarker and therapeutic target in periodontitis via THBS1 regulation	2
miR-31-5p from placental and peripheral blood exosomes is a potential biomarker to diagnose preeclampsia	2
Genomics in animal breeding from the perspectives of matrices and molecules	2
LncRNA LUCAT1 as a prognostic biomarker in cholangiocarcinoma through targeting miR-141-3p: clinical and functional insights	2
Carnosic acid enhances cisplatin sensitivity and suppresses gastric cancer progression via the TP53/SLC7A11/ALOX12 axis	2
Characterization of key genes and immune cell infiltration associated with endometriosis through integrating bioinformatics and experimental analyses	2
Analysis of spermidine’s effect on coronary heart disease risk using bidirectional Mendelian randomization and LC-MS/MS	2
Predicting the therapeutic role and potential mechanisms of Indole-3-acetic acid in diminished ovarian reserve based on network pharmacology and molecular docking	2
A novel molecular subtypes and risk model based on inflammatory response-related lncrnas for bladder cancer	2
Understanding the contemporary high obesity rate from an evolutionary genetic perspective	2
Knockdown of IGF2BP2 overcomes cisplatin-resistance in lung cancer through downregulating Spon2 gene	2