OOIR: Observatory of International Research

Papers

(The TQCC of Hereditas is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Insulin-like growth factor binding protein 2: a core biomarker of left ventricular dysfunction in dilated cardiomyopathy	41
A novel chromatin regulator-related immune checkpoint related gene prognostic signature and potential candidate drugs for endometrial cancer patients	28
Upregulation of CENPM is associated with poor clinical outcome and suppression of immune profile in clear cell renal cell carcinoma	26
Prognostic value of LncRNA PSMA3-AS1 in prostate cancer and its potential regulatory mechanism	22
Extracellular vesicle-derived TP53BP1, CD34, and PBX1 from human peripheral blood serve as potential biomarkers for the assessment and prediction of vascular aging	22
Identification and validation of USP15 and CUL2 as ubiquitination related biomarker in chronic obstructive pulmonary disease	20
Prognostic value of Linc00662/miR-16-5p/FASN in cervical cancer and regulation of tumor progression	19
LncRNA WAC-AS1 expression in human tumors correlates with immune infiltration and affects prognosis	18
Integrating bioinformatics analysis, machine learning, and experimental validation to identify pyroptosis-related genes in the diagnosis of sepsis combined with acute liver failure	18
A cuproptosis-related lncRNA signature for predicting prognosis and immunotherapy response of lung adenocarcinoma	17
E2F1-driven EXOSC10 transcription promotes hepatocellular carcinoma growth and stemness: a potential therapeutic target	17
Comprehensive evaluations of individual discrimination, kinship analysis, genetic relationship exploration and biogeographic origin prediction in Chinese Dongxiang group by a 60-plex DIP panel	16
Mediating Mendelian randomization in the proteome identified potential drug targets for obesity-related allergic asthma	14
An artificial neural network model based on autophagy-related genes in childhood systemic lupus erythematosus	13
Cell-free DNA from plasma as a promising alternative for detection of gene mutations in patients with Maffucci syndrome	12
Gene expression trend changes in breast cancer populations over two decades: insights from The Cancer Genome Atlas database	11
Comprehensive analysis to identify pseudogenes/lncRNAs-hsa-miR-200b-3p-COL5A2 network as a prognostic biomarker in gastric cancer	11
Stable populations and Hardy-Weinberg equilibrium	11
An 8-gene predicting survival model of hepatocellular carcinoma (HCC) related to pyroptosis and cuproptosis	10
Systematic evaluations of forensic effectiveness and genetic structures of two ethnic groups in Northwest China using a self-developed Multi-InDel panel	10
In silico and in vitro assessment of TP53, ATM, RAD51, and BAX genes in gastric cancer and their contribution to radiotherapy resistance	9
WMRCA + : a weighted majority rule-based clustering method for cancer subtype prediction using metabolic gene sets	9
Enhancer analysis of the Drosophila zinc finger transcription factor Earmuff by gene targeting	8
RNA-Seq based transcriptome analysis in oral lichen planus	8
MiR−33 as a novel diagnostic biomarker for distinguishing cholesterol from adenomatous polyps: a case-control study	8

Exploring the anticancer potential of green synthesized Zn/Cu nanocomposites from olive leaves against lung cancer	8
The causal effects between low back pain and cerebrospinal fluid metabolites: a two-sample Mendelian randomization study	8
A guide to barley mutants	8
Mechanism of LINC00958 in ferroptosis of breast cancer through the SRSF1/GPX4 axis	7
Susceptibility genes of hyperuricemia and gout	7
Enhancer-driven transcription of MCM8 by E2F4 promotes ATR pathway activation and glioma stem cell characteristics	7
Structural and functional assessment of TBX20 gene variants in pediatric ventricular septal defect	6
SREBF1, a target gene of multiple sclerosis and coronary heart disease: based on mendelian randomization study	6
Identification and validation of CDC20 and ITCH as ubiquitination related biomarker in idiopathic pulmonary fibrosis	6
CircCENPM serves as a CeRNA to aggravate nasopharyngeal carcinoma metastasis and stemness via enhancing BMI1	6
Predictive value of microRNA-133a-3p for early urinary incontinence after radical prostatectomy for prostate cancer and its correlation with rehabilitation effects	6
Hsa_circ_0006006 is a potential biomarker for prognosis and cisplatin resistance in non-small cell lung cancer	5
Identification of N6-methyladenosine-associated ferroptosis biomarkers in cervical cancer	5
The causal relationships between gut microbiota and venous thromboembolism: a Mendelian randomization study	5
Integrated multi-omics analysis and machine learning refine molecular subtypes and clinical outcome for hepatocellular carcinoma	5
A bioinformatics analysis of the target role of miRNA-431-5p on KLK6 in colorectal cancer	5
Revisiting bicoid function: complete inactivation reveals an additional fundamental role in Drosophila egg geometry specification	5
Diagnostic and prognostic value of miR-146b-5p in acute pancreatitis	5
Genetic analysis of albinism caused by compound heterozygous mutations of the OCA2 gene in a Chinese family	5
Genetic overlap between sarcoidosis and lung cancer: a combined in silico and in vitro approach	5
Correction to: Performance comparison of four types of target enrichment baits for exome DNA sequencing	5
Exploring the mechanism of dendrobine in treating metabolic associated fatty liver disease based on network pharmacology and experimental validation	5
Qingxie Fuzheng granules attenuate cancer cachexia by restoring gut microbiota homeostasis and suppressing IL-6/NF-κB signaling in colorectal adenocarcinoma	5
Ulnar nerve entrapment syndrome: a special case report	5
Mechanisms of Cynarine for treatment of non-alcoholic fatty liver disease based on the integration of network pharmacology, molecular docking and cell experiment	5
Association between chronic obstructive pulmonary disease and osteoporosis: Mendelian randomization combined with bibliometric analysis	5
The mechanism of Weiqi decoction treating gastric cancer: a work based on network pharmacology and experimental verification	4
The novel circFKBP8/miR-432-5p/E2F7 cascade functions as a regulatory network in breast cancer	4
m6A transferase KIAA1429 mediates the upregulation of LncRNA LINC00968 promoting the progression of gastric cancer cells	4
Circular RNAs: novel noncoding players in male infertility	4
Screening of ulcerative colitis biomarkers and potential pathways based on weighted gene co-expression network, machine learning and ceRNA hypothesis	4
Fine construction of gene coexpression network analysis using GTOM and RECODE detected a critical module of neuroblastoma stages 4 and 4S	4
γ-tocotrienol regulates gastric cancer by targeting notch signaling pathway	4
Investigating the clinical significance of OAS family genes in breast cancer: an in vitro and in silico study	4
Investigation of the molecular mechanism of Xiaoluo Wan in thyroid-associated ophthalmopathy: network analysis and in vivo study	4
Decoding mitochondrial stress genes in DCM: towards precision diagnosis and therapy	4
BHLHE40-mediated RGS16 upregulation: a driver propelling gastric cancer progression via ferroptosis suppression	4
Identification of fatty acid metabolism-related genes in the tumor microenvironment of breast cancer by a development and validation of prognostic index signature	4
Epithelial zinc finger protein in lung adenocarcinoma: prognostic biomarker with molecular and clinical implications	4
β-Nicotinamide mononucleotide alleviates Alcohol-Induced liver injury in a mouse model through activation of NAD+/SIRT1 signaling pathways	4
EZH2 regulates pancreatic cancer cells through E2F1, GLI1, CDK3, and Mcm4	4
A novel risk model consisting of nine platelet-related gene signatures for predicting prognosis, immune features and drug sensitivity in glioma	4
Genetic insights into therapeutic targets for gout: evidence from a multi-omics mendelian randomization study	4
Novel variants require established frameworks: emphasizing the role of ISTH diagnostic and classification guidelines in congenital fibrinogen disorders	3
Effects of fourteen essential minerals and vitamins on acute and chronic tubulointerstitial nephritis: a multivariate Mendelian randomization study	3
The unidirectional phylogeny of Homo sapiens anchors the origin of modern humans in Eurasia	3
Identification of biomarkers, immune infiltration landscape, and treatment targets of ischemia–reperfusion acute kidney injury at an early stage by bioinformatics methods	3
Yi Gong San inhibits tumor immune escape by sensitizing colorectal cancer stem cells via the NF-κB pathway	3
Erianin inhibits the progression of DDP-resistant lung adenocarcinoma by regulating the Wnt/β-catenin pathway and activating the caspase-3 for apoptosis in vitro and in vivo	3
Managing gastrointestinal involvement in cutaneomucosal venous malformation: safety and efficacy of endoscopic sclerotherapy	3

Effect of Wendan decoction granules on preventing endolymphatic hydrops and protecting vestibular function in Guinea pigs	3
Disulfidptosis classification of pancreatic carcinoma reveals correlation with clinical prognosis and immune profile	3
Role of necroptosis and immune infiltration in essential thrombocytosis	3
Elevated HMGB1 promotes the malignant progression and contributes to cisplatin resistance of non-small cell lung cancer	3
Correlation between gut microbiota characteristics and non-small cell lung cancer based on macrogenomics sequencing	2
Identification of immune-related mitochondrial metabolic disorder genes in septic shock using bioinformatics and machine learning	2
Development and implementation of an etiology-based diagnostic framework for acute abdominal pain in emergency settings	2
Multi-Omics analysis and in vitro validation reveal diagnostic and therapeutic roles of novel hub genes in ovarian cancer	2
Screening and analysis of programmed cell death related genes and targeted drugs in sepsis	2
Characterization of key genes and immune cell infiltration associated with endometriosis through integrating bioinformatics and experimental analyses	2
Serum vitamin C levels and risk of osteoporosis: results from a cross-sectional study and Mendelian randomization analysis	2
Transformation and gene-disruption in the apple-pathogen, Neonectria ditissima	2
Knockdown of IGF2BP2 overcomes cisplatin-resistance in lung cancer through downregulating Spon2 gene	2
Identification of crucial genes involved in pathogenesis of regional weakening of the aortic wall	2
Editorial: Celebration of DNA Day	2
Inhibition of microRNA-660-5p decreases breast cancer progression through direct targeting of TMEM41B	2
A novel molecular subtypes and risk model based on inflammatory response-related lncrnas for bladder cancer	2
RNA binding protein ILF3 increases CEP55 mRNA stability to enhance malignant potential of breast cancer cells and suppress ferroptosis	2
The diagnostic and prognostic value of LncRNA FAM3D-AS1 expression in nasopharyngeal carcinoma and its effect on tumor progression and cisplatin resistance	2
Mutations in the acetolactate synthase (ALS) enzyme affect shattercane (Sorghum bicolor) response to ALS-inhibiting herbicides	2
Arecoline promotes proliferation and migration of human HepG2 cells through activation of the PI3K/AKT/mTOR pathway	2
Acetylation proteomics and metabolomics analyses reveal the involvement of starch synthase undergoing acetylation modification during UV-B stress resistance in Rhododendron Chrysanthum Pall	2
Identification and validation of autophagy-related genes in Kawasaki disease	2
Trimeric complexes of Antp-TBP with TFIIEβ or Exd modulate transcriptional activity	2
Integrated single-cell and bulk transcriptomic profiling reveals cancer-associated fibroblast heterogeneity in glioblastoma and establishes a clinically actionable prognostic model and preliminary exp	2
WDR62 affects the progression of ovarian cancer by regulating the cell cycle	2
Predicting the therapeutic role and potential mechanisms of Indole-3-acetic acid in diminished ovarian reserve based on network pharmacology and molecular docking	2
Efficacy of red ointment in wound cavity repair following non-puerperal mastitis debridement	2
Understanding the contemporary high obesity rate from an evolutionary genetic perspective	2
Programmed death 1 inhibitor combined with radiotherapy decreases epidermal growth factor receptor expression in breast cancer	2
TFAP2A promotes NSCLC malignant progression by enhancing AOC1 transcription	2
Protein content and HvNAM alleles in Nordic barley (Hordeum vulgare) during a century of breeding	2
Mutation update of SERPING1 related to hereditary angioedema in the Chinese population	2
Correction: Identification and functional characterization of key biomarkers in diffuse large B-cell lymphoma: emphasis on STYX as a prognostic marker and therapeutic target	2
Mechanistic insights into CDCA gene family-mediated glioblastoma progression: implications for diagnosis, prognosis, and therapeutic targeting	2
Suppression of circ_0091761 ameliorates acute myocardial infarction-induced endothelial injury through regulation of miR-1278	2
Mechanistic evaluation of a traditional herbal decoction in attenuating hepatic fibrosis via Nrf2/GPX4 pathway activation and ferroptosis inhibition	2