OOIR: Observatory of International Research

Papers

(The median citation count of Immune Network is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Phosphatase Ssu72 Is Essential for Homeostatic Balance Between CD4⁺ T Cell Lineages	80
Sphingosylphosphorylcholine Promotes Th9 Cell Differentiation Through Regulation of Smad3, STAT5, and β-Catenin Pathways	53
Advances in IL-2 Family Cytokine-Based Cancer Therapies: Overcoming Challenges Through Molecular Engineering and Delivery Strategies	44
Extracellular Mechanisms of Neutrophils in Immune Cell Crosstalk	44
Beyond Tumor Borders: Intratumoral Microbiome Effects on Tumor Behavior and Therapeutic Responses	39
Harnessing the Gut Microbiota to Improve Cancer Immunotherapy: Focus on Lung Cancer	36
The Role of CD4 T Cell Help in CD8 T Cell Differentiation and Function During Chronic Infection and Cancer	33
Distinct T Cell Dysregulation Reflects Disease Severity and Progression in Infantile Epileptic Spasms Syndrome and Lennox-Gastaut Syndrome	27
IL-1 Receptor Dynamics in Immune Cells: Orchestrating Immune Precision and Balance	27
Current Developments in NK Cell Engagers for Cancer Immunotherapy: Focus on CD16A and NKp46	27
Intestinal Dysbiosis Caused by Epithelial Fabp6 Gene Disruption Exacerbates Gut Inflammatory Disease	27
Optimising IL-2 for Cancer Immunotherapy	26
Efficient In Vitro Plasma Cell Differentiation by B Cell Receptor Activation and Cytokine Stimulation	25
Glucocorticoids Impair the 7α-Hydroxycholesterol-Enhanced Innate Immune Response	25
Strong Immune Privileges of MSC and Other Nes-GFP⁺ Progenitors in Bone Marrow of Transgenic Mice	25
STING-STAT6 Signaling Pathway Promotes IL-4⁺ and IFN-α⁺ Fibrotic T Cell Activation and Exacerbates Scleroderma in SKG Mice	24
Altered Frequency, Activation, and Clinical Relevance of Circulating Innate and Innate-Like Lymphocytes in Patients With Alcoholic Liver Cirrhosis	24
COVID-19 Therapeutics: An Update on Effective Treatments Against Infection With SARS-CoV-2 Variants	23
Increased Inflammatory Responses in Patients With Active Disseminated Non-Tuberculous Mycobacterial Infection and High Anti-Interferon-Gamma Autoantibodies	23
From Ex Vivo to In Vivo : Advances in Lentiviral Vector Engineering for CAR-T Therapy	22
Oxidized LDL Accelerates Cartilage Destruction and Inflammatory Chondrocyte Death in Osteoarthritis by Disrupting the TFEB-Regulated Autophagy-Lysosome Pathway	20
Tissue-Specific Metabolic Reprogramming in Innate Lymphoid Cells and Its Impact on Disease	20
Cigarette Smoke Extract-Treated Mouse Airway Epithelial Cells-Derived Exosomal LncRNA MEG3 Promotes M1 Macrophage Polarization and Pyroptosis in Chronic Obstructive Pulmonary Disease by Upregulating T	20
Recombinant Human Bone Morphogenetic Protein-2 Priming of Mesenchymal Stem Cells Ameliorate Acute Lung Injury by Inducing Regulatory T Cells	19
Transcriptional and Epigenetic Regulation of Context-Dependent Plasticity in T-Helper Lineages	19

Exploring the Potential of Glycolytic Modulation in Myeloid-Derived Suppressor Cells for Immunotherapy and Disease Management	18
Neutrophil Migration Is Mediated by VLA-6 in the Inflamed Adipose Tissue	18
Vaccine Strategy That Enhances the Protective Efficacy of Systemic Immunization by Establishing Lung-Resident Memory CD8 T Cells Against Influenza Infection	17
SiglecF Expressing Neutrophils Exacerbate Th17-Mediated Autoimmune Neuroinflammation	17
Regulatory T Cell Metabolism: A Promising Therapeutic Target for Cancer Treatment?	16
Unlocking IL-33: New Insights into Tumor Immunity	15
IL7-TBRII, a Dual Cytokine Modulator Targeting IL-7 and TGF-β Pathways, Inhibits Tumor Progression and Metastasis	14
Soluble CCR2-Expressing Mesenchymal Stem Cells Inhibit Osteoarthritis Development and Progression	14
Enigmatic Roles of Complement Anaphylatoxin Signaling in Health and Disease	14
Shaping Heterogeneity of Naive CD8⁺ T Cell Pools	14
Virus-like Particle Vaccines Containing RSV Fusion Protein Cleavage Mutations Are Immunogenic and Protective in Cotton Rats With a Prime Dose	13
Distinct Transcriptional and Functional Differences of Lung Resident and Monocyte-Derived Alveolar Macrophages During the Recovery Period of Acute Lung Injury	12
Dynamic Interplay Between Tumor Cells and the Immune System	12
NLRP3 Exacerbate NETosis-Associated Neuroinflammation in an LPS-Induced Inflamed Brain	12
Decay-Accelerating Factor Differentially Associates With Complement-Mediated Damage in Synovium After Meniscus Tear as Compared to Anterior Cruciate Ligament Injury	12
Mitochondria Activity and CXCR4 Collaboratively Promote the Differentiation of CD11c⁺ B Cells Induced by TLR9 in Lupus	12
Monovalent Anti-CD3 Antibodies Effectively Eliminate the TCR-Positive Fraction of TCR-Deleted Allogeneic CAR-T Cells to Prevent GVHD	12
Comparing the Benefits and Drawbacks of Stem Cell Therapy Based on the Cell Origin or Manipulation Process: Addressing Immunogenicity	12
NADPH Oxidase 4-mediated Alveolar Macrophage Recruitment to Lung Attenuates Neutrophilic Inflammation in Staphylococcus aureus Infection	11
Aging Mediates Inflammatory Transformation of Kidney-Resident Macrophages via Thrombospondin-1 Signaling	10
Mitochondrial Regulator CRIF1 Plays a Critical Role in the Development and Homeostasis of Alveolar Macrophages via Maintaining Metabolic Fitness	10
Low-Dose Radiotherapy Attenuates Experimental Autoimmune Arthritis by Inducing Apoptosis of Lymphocytes and Fibroblast-Like Synoviocytes	9
A Moonlighting Protein Secreted by a Nasal Microbiome Fortifies the Innate Host Defense Against Bacterial and Viral Infections	9
The Multifaceted Roles of NK Cells in the Context of Murine Cytomegalovirus and Lymphocytic Choriomeningitis Virus Infections	9
Regulation of Ferroptosis in Cancer and Immune Cells	9
Regulatory T Cell Heterogeneity in the Steady State and Tumor	8
Adoptive Cellular Therapies in Pediatric Leukemia Patients After Allogeneic-Hematopoietic Stem Cell Transplants	8
Tissue-Resident ILC2s Across Organs: Heterogeneity, Niche Crosstalk, and Shared Regulatory Circuits	7
Tumor Cells as Architects of Immune Refractoriness: Dismantling Intrinsic Programs of Tumor Cells for Clinical Translation	7
T Cell Microvilli: Finger-Shaped External Structures Linked to the Fate of T Cells	7
The Impact of Pulmonary Disorders on Neurological Health (Lung-Brain Axis)	7
Recombinant Human IL-32θ Induces Polarization Into M1-like Macrophage in Human Monocytic Cells	7
The Role of Inflammasome-Associated Innate Immune Receptors in Cancer	7
Metabolic Challenges in Anticancer CD8 T Cell Functions	7
Roles of Virtual Memory T Cells in Diseases	7
Cytokine Storm Related to CD4⁺ T Cells in Influenza Virus-Associated Acute Necrotizing Encephalopathy	6
Modulation of Immune Responses by Metabolic Reprogramming: The Key Role of Immunometabolism	6
Diverse Functions of Macrophages in Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease: Bridging Inflammation and Metabolism	6
COVID-19 Vaccination Alters NK Cell Dynamics and Transiently Reduces HBsAg Titers Among Patients With Chronic Hepatitis B	6
Interleukin-18 Binding Protein (IL-18BP): A Long Journey From Discovery to Clinical Application	6
Bifidobacterium longum RAPO Attenuates Dermal and Pulmonary Fibrosis in a Mouse Model of Systemic Sclerosis through Macrophage Modulation and Growth of Short-Chain Fatty Acid Producers	6
Bone Marrow Progenitors and IL-2 Signaling Contribute to the Strain Differences of Kidney Innate Lymphoid Cells	6
Comprehensive Transcriptomic Analysis for Thymic Epithelial Cells of Aged Mice and Humans	6
Cytokines, Vascular Endothelial Growth Factors, and PlGF in Autoimmunity: Insights From Rheumatoid Arthritis to Multiple Sclerosis	6
IL-17 and IL-21: Their Immunobiology and Therapeutic Potentials	5
Immune Cells Are Differentially Affected by SARS-CoV-2 Viral Loads in K18-hACE2 Mice	5
T Cell Resistance: On the Mechanisms of T Cell Non-activation	5
Influenza Virus-Derived CD8 T Cell Epitopes: Implications for the Development of Universal Influenza Vaccines	5
Role of the Aryl Hydrocarbon Receptor in the Self-Renewal, Differentiation, and Immunomodulation of Adult Stem Cells	5
Cytokines and Immune Disorders: Illuminating Cytokines as Hubs Within the Immune Network	5

Cytokine Engineering in CAR-T Cell Therapy: Next-Generation Strategies