OOIR: Observatory of International Research

Papers

(The median citation count of Immune Network is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Phosphatase Ssu72 Is Essential for Homeostatic Balance Between CD4⁺ T Cell Lineages	134
Sphingosylphosphorylcholine Promotes Th9 Cell Differentiation Through Regulation of Smad3, STAT5, and β-Catenin Pathways	133
Dietary Diversity during Early Infancy Increases Microbial Diversity and Prevents Egg Allergy in High-Risk Infants	52
Extracellular Mechanisms of Neutrophils in Immune Cell Crosstalk	39
IL-1 Receptor Dynamics in Immune Cells: Orchestrating Immune Precision and Balance	37
Amelioration of DSS-Induced Acute Colitis in Mice by Recombinant Monomeric Human Interleukin-22	35
Distinct T Cell Dysregulation Reflects Disease Severity and Progression in Infantile Epileptic Spasms Syndrome and Lennox-Gastaut Syndrome	33
Impairment of Mitochondrial ATP Synthesis Induces RIPK3-dependent Necroptosis in Lung Epithelial Cells During Lung Injury by Lung Inflammation	33
The Role of CD4 T Cell Help in CD8 T Cell Differentiation and Function During Chronic Infection and Cancer	33
Modeling Incorporating the Severity-Reducing Long-term Immunity: Higher Viral Transmission Paradoxically Reduces Severe COVID-19 During Endemic Transition	33
Beyond Tumor Borders: Intratumoral Microbiome Effects on Tumor Behavior and Therapeutic Responses	32
Current Developments in NK Cell Engagers for Cancer Immunotherapy: Focus on CD16A and NKp46	31
Intestinal Dysbiosis Caused by Epithelial Fabp6 Gene Disruption Exacerbates Gut Inflammatory Disease	28
Context-Dependent Regulation of Type17 Immunity by Microbiota at the Intestinal Barrier	24
Optimising IL-2 for Cancer Immunotherapy	24
Efficient In Vitro Plasma Cell Differentiation by B Cell Receptor Activation and Cytokine Stimulation	23
CAR T Cell Immunotherapy Beyond Haematological Malignancy	23
Increased B Cell Understanding Puts Improved Vaccine Platforms Just Over the Horizon	22
Outstanding Features of COVID-19 Overlapping Primary Immunodeficiency in Children	21
Strong Immune Privileges of MSC and Other Nes-GFP⁺ Progenitors in Bone Marrow of Transgenic Mice	21
Glucocorticoids Impair the 7α-Hydroxycholesterol-Enhanced Innate Immune Response	21
Development of Bispecific Antibody for Cancer Immunotherapy: Focus on T Cell Engaging Antibody	20
STING-STAT6 Signaling Pathway Promotes IL-4⁺ and IFN-α⁺ Fibrotic T Cell Activation and Exacerbates Scleroderma in SKG Mice	20
Increased Inflammatory Responses in Patients With Active Disseminated Non-Tuberculous Mycobacterial Infection and High Anti-Interferon-Gamma Autoantibodies	19
Altered Frequency, Activation, and Clinical Relevance of Circulating Innate and Innate-Like Lymphocytes in Patients With Alcoholic Liver Cirrhosis	19

Transcriptional and Epigenetic Regulation of Context-Dependent Plasticity in T-Helper Lineages	18
Oxidized LDL Accelerates Cartilage Destruction and Inflammatory Chondrocyte Death in Osteoarthritis by Disrupting the TFEB-Regulated Autophagy-Lysosome Pathway	18
Tissue-Specific Metabolic Reprogramming in Innate Lymphoid Cells and Its Impact on Disease	18
Characterization of Immune Cells From the Lungs of Patients With Chronic Non-Tuberculous Mycobacteria or Pseudomonas aeruginosa Infection	18
Neutrophil Migration Is Mediated by VLA-6 in the Inflamed Adipose Tissue	17
Recombinant Human Bone Morphogenetic Protein-2 Priming of Mesenchymal Stem Cells Ameliorate Acute Lung Injury by Inducing Regulatory T Cells	17
COVID-19 Therapeutics: An Update on Effective Treatments Against Infection With SARS-CoV-2 Variants	17
Exploring the Potential of Glycolytic Modulation in Myeloid-Derived Suppressor Cells for Immunotherapy and Disease Management	17
SiglecF Expressing Neutrophils Exacerbate Th17-Mediated Autoimmune Neuroinflammation	17
Cigarette Smoke Extract-Treated Mouse Airway Epithelial Cells-Derived Exosomal LncRNA MEG3 Promotes M1 Macrophage Polarization and Pyroptosis in Chronic Obstructive Pulmonary Disease by Upregulating T	17
Vaccine Strategy That Enhances the Protective Efficacy of Systemic Immunization by Establishing Lung-Resident Memory CD8 T Cells Against Influenza Infection	17
Shaping Heterogeneity of Naive CD8⁺ T Cell Pools	15
Immunopathology and Immunotherapy of Inflammatory Skin Diseases	15
Change of Dendritic Cell Subsets Involved in Protection Against Listeria monocytogenes Infection in Short-Term-Fasted Mice	15
Unlocking IL-33: New Insights into Tumor Immunity	15
Regulatory T Cell Metabolism: A Promising Therapeutic Target for Cancer Treatment?	15
SOCS3 Attenuates Dexamethasone-Induced M2 Polarization by Down-Regulation of GILZ via ROS- and p38 MAPK-Dependent Pathways	15
Enigmatic Roles of Complement Anaphylatoxin Signaling in Health and Disease	14
IL7-TBRII, a Dual Cytokine Modulator Targeting IL-7 and TGF-β Pathways, Inhibits Tumor Progression and Metastasis	14
Soluble CCR2-Expressing Mesenchymal Stem Cells Inhibit Osteoarthritis Development and Progression	14
Commensal Microbiota and Cancer Immunotherapy: Harnessing Commensal Bacteria for Cancer Therapy	13
Mitochondria Activity and CXCR4 Collaboratively Promote the Differentiation of CD11c⁺ B Cells Induced by TLR9 in Lupus	13
Virus-like Particle Vaccines Containing RSV Fusion Protein Cleavage Mutations Are Immunogenic and Protective in Cotton Rats With a Prime Dose	13
Dexamethasone, but Not Vitamin D or A, Dampens the Inflammatory Neutrophil Response to Protect At-risk COVID-19 Patients	12
NLRP3 Exacerbate NETosis-Associated Neuroinflammation in an LPS-Induced Inflamed Brain	12
Obesity Exacerbates Coxsackievirus Infection via Lipid-Induced Mitochondrial Reactive Oxygen Species Generation	11
NADPH Oxidase 4-mediated Alveolar Macrophage Recruitment to Lung Attenuates Neutrophilic Inflammation in Staphylococcus aureus Infection	11
Distinct Transcriptional and Functional Differences of Lung Resident and Monocyte-Derived Alveolar Macrophages During the Recovery Period of Acute Lung Injury	11
Monovalent Anti-CD3 Antibodies Effectively Eliminate the TCR-Positive Fraction of TCR-Deleted Allogeneic CAR-T Cells to Prevent GVHD	11
Decay-Accelerating Factor Differentially Associates With Complement-Mediated Damage in Synovium After Meniscus Tear as Compared to Anterior Cruciate Ligament Injury	11
Comparing the Benefits and Drawbacks of Stem Cell Therapy Based on the Cell Origin or Manipulation Process: Addressing Immunogenicity	11
Mitochondrial Regulator CRIF1 Plays a Critical Role in the Development and Homeostasis of Alveolar Macrophages via Maintaining Metabolic Fitness	11
Trypanosoma cruzi Dysregulates piRNAs Computationally Predicted to Target IL-6 Signaling Molecules During Early Infection of Primary Human Cardiac Fibroblasts	10
The Multifaceted Roles of NK Cells in the Context of Murine Cytomegalovirus and Lymphocytic Choriomeningitis Virus Infections	10
Aging Mediates Inflammatory Transformation of Kidney-Resident Macrophages via Thrombospondin-1 Signaling	10
A Moonlighting Protein Secreted by a Nasal Microbiome Fortifies the Innate Host Defense Against Bacterial and Viral Infections	10
The Impact of Pulmonary Disorders on Neurological Health (Lung-Brain Axis)	9
Regulation of Ferroptosis in Cancer and Immune Cells	9
Recombinant Human IL-32θ Induces Polarization Into M1-like Macrophage in Human Monocytic Cells	9
Metabolic Challenges in Anticancer CD8 T Cell Functions	9
Low-Dose Radiotherapy Attenuates Experimental Autoimmune Arthritis by Inducing Apoptosis of Lymphocytes and Fibroblast-Like Synoviocytes	9
Omicron Subvariants, Including BA.4 and BA.5, Substantially Preserve T Cell Epitopes of Ancestral SARS-CoV-2	9
Adoptive Cellular Therapies in Pediatric Leukemia Patients After Allogeneic-Hematopoietic Stem Cell Transplants	9
The Role of Inflammasome-Associated Innate Immune Receptors in Cancer	8
Mitochondrial Transplantation Ameliorates the Development and Progression of Osteoarthritis	8
Comprehensive Transcriptomic Analysis for Thymic Epithelial Cells of Aged Mice and Humans	8
Tissue-Resident ILC2s Across Organs: Heterogeneity, Niche Crosstalk, and Shared Regulatory Circuits	8
Cytokines, Vascular Endothelial Growth Factors, and PlGF in Autoimmunity: Insights From Rheumatoid Arthritis to Multiple Sclerosis	8
Bifidobacterium longum RAPO Attenuates Dermal and Pulmonary Fibrosis in a Mouse Model of Systemic Sclerosis through Macrophage Modulation and Growth of Short-Chain Fatty Acid Producers	8
T Cell Microvilli: Finger-Shaped External Structures Linked to the Fate of T Cells	8

Cytokine Inductions and Intracellular Signal Profiles by Stimulation of dsRNA and SEB in the Macrophages and Epithelial Cells	7
Interleukin-18 Binding Protein (IL-18BP): A Long Journey From Discovery to Clinical Application	7
Roles of Virtual Memory T Cells in Diseases	7
Modulation of Immune Responses by Metabolic Reprogramming: The Key Role of Immunometabolism	7
Diverse Functions of Macrophages in Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease: Bridging Inflammation and Metabolism	7
T Cell Resistance: On the Mechanisms of T Cell Non-activation	6
Evaluation of Immunoproteasome-Specific Proteolytic Activity Using Fluorogenic Peptide Substrates	6
Advancements of Common Gamma-Chain Family Cytokines in Cancer Immunotherapy	6
Engineering Cell Therapies for Autoimmune Diseases: From Preclinical to Clinical Proof of Concept	6
Bone Marrow Progenitors and IL-2 Signaling Contribute to the Strain Differences of Kidney Innate Lymphoid Cells	6
Cytokine Storm Related to CD4⁺ T Cells in Influenza Virus-Associated Acute Necrotizing Encephalopathy	6
Influenza Virus-Derived CD8 T Cell Epitopes: Implications for the Development of Universal Influenza Vaccines	6
COVID-19 Vaccination Alters NK Cell Dynamics and Transiently Reduces HBsAg Titers Among Patients With Chronic Hepatitis B	6
Cytokines and Immune Disorders: Illuminating Cytokines as Hubs Within the Immune Network	6
Recent Advances in Allergen-Specific Immunotherapy in Humans: A Systematic Review	5
Tobacco Smoking Could Accentuate Epithelial-Mesenchymal Transition and Th2-Type Response in Patients With Chronic Rhinosinusitis With Nasal Polyps	5
Ubiquitin-like Proteins in Autoimmune Diseases: Current Evidence and Therapeutic Opportunities	5
Patients With Mild COVID-19 Exhibit Low Functional Avidity of SARS-CoV-2 Membrane Protein-Reactive CD4⁺ T Cells	5
Application of Antimicrobial Peptide LL-37 as an Adjuvant for Middle East Respiratory Syndrome-Coronavirus Antigen Induces an Efficient Protective Immune Response Against Viral Infection After Intrana	5
Cytokine Engineering in CAR-T Cell Therapy: Next-Generation Strategies	5
Exosomes in Action: Unraveling Their Role in Autoimmune Diseases and Exploring Potential Therapeutic Applications	5
Targeted Immunotherapy for Autoimmune Disease	5
A Novel Approach of T Cell Receptor Classification Reveals Dynamic Interactions Amongst Diet, Microbiota, and Host T Cells	5
IL-17 and IL-21: Their Immunobiology and Therapeutic Potentials	5
Immune Cells Are Differentially Affected by SARS-CoV-2 Viral Loads in K18-hACE2 Mice	5
Synovial Fluid as a Crucial Component of the Joint Microenvironment in Rheumatoid Arthritis	5
SARS-CoV-2 mRNA Vaccine Elicits Sustained T Cell Responses Against the Omicron Variant in Adolescents	5
Role of the Aryl Hydrocarbon Receptor in the Self-Renewal, Differentiation, and Immunomodulation of Adult Stem Cells	5