OOIR: Observatory of International Research

Papers

(The median citation count of Immune Network is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Phosphatase Ssu72 Is Essential for Homeostatic Balance Between CD4⁺ T Cell Lineages	125
Sphingosylphosphorylcholine Promotes Th9 Cell Differentiation Through Regulation of Smad3, STAT5, and β-Catenin Pathways	124
Dietary Diversity during Early Infancy Increases Microbial Diversity and Prevents Egg Allergy in High-Risk Infants	48
Extracellular Mechanisms of Neutrophils in Immune Cell Crosstalk	33
Beyond Tumor Borders: Intratumoral Microbiome Effects on Tumor Behavior and Therapeutic Responses	32
Impairment of Mitochondrial ATP Synthesis Induces RIPK3-dependent Necroptosis in Lung Epithelial Cells During Lung Injury by Lung Inflammation	32
Distinct T Cell Dysregulation Reflects Disease Severity and Progression in Infantile Epileptic Spasms Syndrome and Lennox-Gastaut Syndrome	31
Current Developments in NK Cell Engagers for Cancer Immunotherapy: Focus on CD16A and NKp46	30
IL-1 Receptor Dynamics in Immune Cells: Orchestrating Immune Precision and Balance	29
Amelioration of DSS-Induced Acute Colitis in Mice by Recombinant Monomeric Human Interleukin-22	29
The Role of CD4 T Cell Help in CD8 T Cell Differentiation and Function During Chronic Infection and Cancer	28
Modeling Incorporating the Severity-Reducing Long-term Immunity: Higher Viral Transmission Paradoxically Reduces Severe COVID-19 During Endemic Transition	24
CAR T Cell Immunotherapy Beyond Haematological Malignancy	23
Optimising IL-2 for Cancer Immunotherapy	23
Context-Dependent Regulation of Type17 Immunity by Microbiota at the Intestinal Barrier	22
Intestinal Dysbiosis Caused by Epithelial Fabp6 Gene Disruption Exacerbates Gut Inflammatory Disease	21
Efficient In Vitro Plasma Cell Differentiation by B Cell Receptor Activation and Cytokine Stimulation	20
Increased B Cell Understanding Puts Improved Vaccine Platforms Just Over the Horizon	19
Outstanding Features of COVID-19 Overlapping Primary Immunodeficiency in Children	19
Strong Immune Privileges of MSC and Other Nes-GFP⁺ Progenitors in Bone Marrow of Transgenic Mice	19
STING-STAT6 Signaling Pathway Promotes IL-4⁺ and IFN-α⁺ Fibrotic T Cell Activation and Exacerbates Scleroderma in SKG Mice	18
Altered Frequency, Activation, and Clinical Relevance of Circulating Innate and Innate-Like Lymphocytes in Patients With Alcoholic Liver Cirrhosis	18
Glucocorticoids Impair the 7α-Hydroxycholesterol-Enhanced Innate Immune Response	18
Development of Bispecific Antibody for Cancer Immunotherapy: Focus on T Cell Engaging Antibody	18
Oxidized LDL Accelerates Cartilage Destruction and Inflammatory Chondrocyte Death in Osteoarthritis by Disrupting the TFEB-Regulated Autophagy-Lysosome Pathway	17

Tissue-Specific Metabolic Reprogramming in Innate Lymphoid Cells and Its Impact on Disease	17
Characterization of Immune Cells From the Lungs of Patients With Chronic Non-Tuberculous Mycobacteria or Pseudomonas aeruginosa Infection	17
Increased Inflammatory Responses in Patients With Active Disseminated Non-Tuberculous Mycobacterial Infection and High Anti-Interferon-Gamma Autoantibodies	17
Neutrophil Migration Is Mediated by VLA-6 in the Inflamed Adipose Tissue	16
Transcriptional and Epigenetic Regulation of Context-Dependent Plasticity in T-Helper Lineages	16
Cigarette Smoke Extract-Treated Mouse Airway Epithelial Cells-Derived Exosomal LncRNA MEG3 Promotes M1 Macrophage Polarization and Pyroptosis in Chronic Obstructive Pulmonary Disease by Upregulating T	16
COVID-19 Therapeutics: An Update on Effective Treatments Against Infection With SARS-CoV-2 Variants	16
Exploring the Potential of Glycolytic Modulation in Myeloid-Derived Suppressor Cells for Immunotherapy and Disease Management	15
Vaccine Strategy That Enhances the Protective Efficacy of Systemic Immunization by Establishing Lung-Resident Memory CD8 T Cells Against Influenza Infection	15
Recombinant Human Bone Morphogenetic Protein-2 Priming of Mesenchymal Stem Cells Ameliorate Acute Lung Injury by Inducing Regulatory T Cells	15
Shaping Heterogeneity of Naive CD8⁺ T Cell Pools	15
SOCS3 Attenuates Dexamethasone-Induced M2 Polarization by Down-Regulation of GILZ via ROS- and p38 MAPK-Dependent Pathways	14
Immunopathology and Immunotherapy of Inflammatory Skin Diseases	14
Regulatory T Cell Metabolism: A Promising Therapeutic Target for Cancer Treatment?	14
SiglecF Expressing Neutrophils Exacerbate Th17-Mediated Autoimmune Neuroinflammation	14
Unlocking IL-33: New Insights into Tumor Immunity	14
Soluble CCR2-Expressing Mesenchymal Stem Cells Inhibit Osteoarthritis Development and Progression	13
Enigmatic Roles of Complement Anaphylatoxin Signaling in Health and Disease	13
Change of Dendritic Cell Subsets Involved in Protection Against Listeria monocytogenes Infection in Short-Term-Fasted Mice	13
Mitochondria Activity and CXCR4 Collaboratively Promote the Differentiation of CD11c⁺ B Cells Induced by TLR9 in Lupus	13
Dexamethasone, but Not Vitamin D or A, Dampens the Inflammatory Neutrophil Response to Protect At-risk COVID-19 Patients	12
Commensal Microbiota and Cancer Immunotherapy: Harnessing Commensal Bacteria for Cancer Therapy	12
Virus-like Particle Vaccines Containing RSV Fusion Protein Cleavage Mutations Are Immunogenic and Protective in Cotton Rats With a Prime Dose	12
NLRP3 Exacerbate NETosis-Associated Neuroinflammation in an LPS-Induced Inflamed Brain	11
Monovalent Anti-CD3 Antibodies Effectively Eliminate the TCR-Positive Fraction of TCR-Deleted Allogeneic CAR-T Cells to Prevent GVHD	11
Distinct Transcriptional and Functional Differences of Lung Resident and Monocyte-Derived Alveolar Macrophages During the Recovery Period of Acute Lung Injury	11
NADPH Oxidase 4-mediated Alveolar Macrophage Recruitment to Lung Attenuates Neutrophilic Inflammation in Staphylococcus aureus Infection	11
Mitochondrial Regulator CRIF1 Plays a Critical Role in the Development and Homeostasis of Alveolar Macrophages via Maintaining Metabolic Fitness	10
Comparing the Benefits and Drawbacks of Stem Cell Therapy Based on the Cell Origin or Manipulation Process: Addressing Immunogenicity	10
Decay-Accelerating Factor Differentially Associates With Complement-Mediated Damage in Synovium After Meniscus Tear as Compared to Anterior Cruciate Ligament Injury	10
Trypanosoma cruzi Dysregulates piRNAs Computationally Predicted to Target IL-6 Signaling Molecules During Early Infection of Primary Human Cardiac Fibroblasts	9
Obesity Exacerbates Coxsackievirus Infection via Lipid-Induced Mitochondrial Reactive Oxygen Species Generation	9
Low-Dose Radiotherapy Attenuates Experimental Autoimmune Arthritis by Inducing Apoptosis of Lymphocytes and Fibroblast-Like Synoviocytes	9
Regulation of Ferroptosis in Cancer and Immune Cells	9
A Moonlighting Protein Secreted by a Nasal Microbiome Fortifies the Innate Host Defense Against Bacterial and Viral Infections	9
The Multifaceted Roles of NK Cells in the Context of Murine Cytomegalovirus and Lymphocytic Choriomeningitis Virus Infections	9
Adoptive Cellular Therapies in Pediatric Leukemia Patients After Allogeneic-Hematopoietic Stem Cell Transplants	8
The Role of Inflammasome-Associated Innate Immune Receptors in Cancer	8
Metabolic Challenges in Anticancer CD8 T Cell Functions	8
The Impact of Pulmonary Disorders on Neurological Health (Lung-Brain Axis)	8
Recombinant Human IL-32θ Induces Polarization Into M1-like Macrophage in Human Monocytic Cells	8
Omicron Subvariants, Including BA.4 and BA.5, Substantially Preserve T Cell Epitopes of Ancestral SARS-CoV-2	8
Roles of Virtual Memory T Cells in Diseases	7
Cytokines, Vascular Endothelial Growth Factors, and PlGF in Autoimmunity: Insights From Rheumatoid Arthritis to Multiple Sclerosis	7
Comprehensive Transcriptomic Analysis for Thymic Epithelial Cells of Aged Mice and Humans	7
T Cell Microvilli: Finger-Shaped External Structures Linked to the Fate of T Cells	7
Bifidobacterium longum RAPO Attenuates Dermal and Pulmonary Fibrosis in a Mouse Model of Systemic Sclerosis through Macrophage Modulation and Growth of Short-Chain Fatty Acid Producers	7
Mitochondrial Transplantation Ameliorates the Development and Progression of Osteoarthritis	7
Cytokine Inductions and Intracellular Signal Profiles by Stimulation of dsRNA and SEB in the Macrophages and Epithelial Cells	6
Bone Marrow Progenitors and IL-2 Signaling Contribute to the Strain Differences of Kidney Innate Lymphoid Cells	6

Modulation of Immune Responses by Metabolic Reprogramming: The Key Role of Immunometabolism	6
Interleukin-18 Binding Protein (IL-18BP): A Long Journey From Discovery to Clinical Application	6
COVID-19 Vaccination Alters NK Cell Dynamics and Transiently Reduces HBsAg Titers Among Patients With Chronic Hepatitis B	6
Evaluation of Immunoproteasome-Specific Proteolytic Activity Using Fluorogenic Peptide Substrates	6
Diverse Functions of Macrophages in Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease: Bridging Inflammation and Metabolism	6
Influenza Virus-Derived CD8 T Cell Epitopes: Implications for the Development of Universal Influenza Vaccines	5
Application of Antimicrobial Peptide LL-37 as an Adjuvant for Middle East Respiratory Syndrome-Coronavirus Antigen Induces an Efficient Protective Immune Response Against Viral Infection After Intrana	5
Recent Advances in Allergen-Specific Immunotherapy in Humans: A Systematic Review	5
Advancements of Common Gamma-Chain Family Cytokines in Cancer Immunotherapy	5
IL-17 and IL-21: Their Immunobiology and Therapeutic Potentials	5
Synovial Fluid as a Crucial Component of the Joint Microenvironment in Rheumatoid Arthritis	5
Ubiquitin-like Proteins in Autoimmune Diseases: Current Evidence and Therapeutic Opportunities	5
Immune Cells Are Differentially Affected by SARS-CoV-2 Viral Loads in K18-hACE2 Mice	5
Cytokine Storm Related to CD4⁺ T Cells in Influenza Virus-Associated Acute Necrotizing Encephalopathy	5
T Cell Resistance: On the Mechanisms of T Cell Non-activation	5
Role of the Aryl Hydrocarbon Receptor in the Self-Renewal, Differentiation, and Immunomodulation of Adult Stem Cells	5
Tobacco Smoking Could Accentuate Epithelial-Mesenchymal Transition and Th2-Type Response in Patients With Chronic Rhinosinusitis With Nasal Polyps	5
Engineering Cell Therapies for Autoimmune Diseases: From Preclinical to Clinical Proof of Concept	5
Cytokines and Immune Disorders: Illuminating Cytokines as Hubs Within the Immune Network	5