OOIR: Observatory of International Research

Papers

(The TQCC of Recent Patents on Anti-Cancer Drug Discovery is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Application of Nano Drug Delivery System (NDDS) in Cancer Therapy: A Perspective	25
Reposition of the Fungicide Ciclopirox for Cancer Treatment	21
Cancer Immunotherapy - Immune Checkpoint Inhibitors in Hepatocellular Carcinoma	18
Current Advances and Outlook in Gastric Cancer Chemoresistance: A Review	18
Phytochemicals as PI3K/ Akt/ mTOR Inhibitors and Their Role in Breast Cancer Treatment	18
Potential Therapeutic Targets of Curcumin, Most Abundant Active Compound of Turmeric Spice: Role in the Management of Various Types of Cancer	17
A Link Between Chemical Structure and Biological Activity in Triterpenoids	15
Effect of PI3K/AKT/mTOR Signaling Pathway on Regulating and Controlling the Anti-Invasion and Metastasis of Hepatoma Cells by Bufalin	15
Gefitinib: An Updated Review of its Role in the Cancer Management, its Nanotechnological Interventions, Recent Patents and Clinical Trials	14
Current Status and Prospects of Camrelizumab, A Humanized Antibody Against Programmed Cell Death Receptor 1	13
Distinct Epigenetic Reprogramming, Mitochondrial Patterns, Cellular Morphology, and Cytotoxicity after Bee Venom Treatment	13
Imitating Hypoxia and Tumor Microenvironment with Immune Evasion by Employing Three Dimensional In vitro Cellular Models: Impressive Tool in Drug Discovery	12
The Patent Landscape of BRAF Target and KRAS Target	11
Interplay between RNA Methylation Eraser FTO and Writer METTL3 in Renal Clear Cell Carcinoma Patient Survival	11
Targeting Cancer Stem Cells with Repurposed Drugs to Improve Current Therapies	11
Anti-EGFR-mAb and 5-Fluorouracil Conjugated Polymeric Nanoparticles for Colorectal Cancer	10
Induced Fit Docking and Automated QSAR Studies Reveal the ER-α Inhibitory Activity of Cannabis sativa in Breast Cancer	10
LINC00936/microRNA-221-3p Regulates Tumor Progression in Ovarian Cancer by Interacting with LAMA3	10
N6-Methyladenosine-Related RNA Signature Predicting the Prognosis of Ovarian Cancer	10
The Efficacy and Mechanism of Proteasome Inhibitors in Solid Tumor Treatment	10
Research and Patents Status of Selected Phytochemicals Against Cancer: How Close and How Far?	10
In Vitro and In Vivo Evaluation of Novel DTX-Loaded Multifunctional Heparin-Based Polymeric Micelles Targeting Folate Receptors and Endosomes	10
Self-immolative Linkers in Prodrugs and Antibody Drug Conjugates in Cancer Treatment	10
Repurposing Chloroquine Analogs as an Adjuvant Cancer Therapy	10
Immunological Mechanism and Clinical Application of PAMP Adjuvants	9

Transdermal Drug Delivery: A Step towards Treatment of Cancer	9
Eudragit, a Nifty Polymer for Anticancer Preparations: A Patent Review	9
Terpenes with Antitumor Activity: A Patent Review	9
Artificial Intelligence and Cancer Drug Development	9
Advancement of Traditional Chinese Medicine in Regulation of Intestinal Flora: Mechanism-based Role in Disease Management	8
Novel Pathways and Mechanisms of Nicotine-Induced Oral Carcinogenesis	8
Recent Trend for EGFR-Based and ALK-Based Targets: A Patent Analysis	8
The Impact of Polyphenolics in the Management of Breast Cancer: Mechanistic Aspects and Recent Patents	8
Metallodrugs as Anticancer Chemotherapeutics and Diagnostic Agents: A Critical Patent Review (2010-2020)	8
Repurposing of Metformin for Cancer Therapy: Updated Patent and Literature Review	8
Anti-Cancer Effect of Melatonin via Downregulation of Delta-like Ligand 4 in Estrogen-Responsive Breast Cancer Cells	8
Anti-cancer Research on Arnebiae radix-derived Naphthoquinone in Recent Five Years	8
Understanding and Targeting the Epigenetic Regulation to Overcome EGFR-TKIs Resistance in Human Cancer	8
STAT3 Inhibitor Napabucasin Inhibits Tumor Growth and Cooperates with Proteasome Inhibition in Human Ovarian Cancer Cells	7
Combining PD-1 Inhibitor with VEGF/VEGFR2 Inhibitor in Chemotherapy: Report of a Patient with End-Stage Cholangiocarcinoma and Review of Literature	7
Anti-EGFR Binding Nanobody Delivery System to Improve the Diagnosis and Treatment of Solid Tumours	7
The Synthesis, Structural Modification and Mode of Anticancer Action of Evodiamine: A Review	7
Natural Product as Substrates of ABC Transporters: A Review	7
High Expression of MYL9 Indicates Poor Clinical Prognosis of Epithelial Ovarian Cancer	7
Ultrasound-Mediated Cancer Therapeutics Delivery using Micelles and Liposomes: A Review	7
Nano-Based Drug Delivery of Anticancer Chemotherapeutic Drugs Targeting Breast Cancer	7
ZFP36L1 Promotes Gastric Cancer Progression via Regulating JNK and p38 MAPK Signaling Pathways	6
Multifunctional Patented Nanotherapeutics for Cancer Intervention: 2010- Onwards	6
The Application of Nanotechnology in Immunotherapy based Combinations for Cancer Treatment	6
Overview of Inorganic Nanoparticles: An Expanding Horizon in Tumor Therapeutics	6
Prognostic and Therapeutic Values of Autophagy-related Genes in Triple-negative Breast Cancer	6
Pseudo-ginsenoside Rh2 Induces Protective Autophagy in Hepatocellular Carcinoma HepG2 Cells	6
An Update of Lysine Specific Demethylase 1 Inhibitor: A Patent Review (2016-2020)	6
Gliotoxin Induced Ferroptosis by Downregulating SUV39H1 Expression in Esophageal Cancer Cells	6
Exploring the Anticancer Potentials of Polyphenols: A Comprehensive Review of Patents in the Last Five Years	6
pH-responsive Sulfated Hyaluronic Acid Nanoparticles Targeting Tumor Cells and CAFs for the Treatment of Breast Cancer	5
Prediction of Cancer Treatment Using Advancements in Machine Learning	5
Alpha-solanine Anti-tumor Effects in Non-small Cell Lung Cancer Through Regulating the Energy Metabolism Pathway	5
Prospective Challenges for Patenting and Clinical Trials of Anticancer Compounds from Natural Products: Coherent Review	5
Recent Patents of Pharmaceutical Co-Crystals: Product Development on Anti-Cancer Drugs and Beyond	5
Human Saliva Metabolome for Oral Lichen Planus Biomarker Identification	5
Daidzein and Chicory Extract Arrest the Cell Cycle via Inhibition of Cyclin D/CDK4 and Cyclin A/CDK2 Gene Expression in Hepatocellular Carcinoma	5
Antioxidant, Anti-Inflammatory and Anticancer Activities of the Methanolic Extract of Thottea siliquosa: An In Vitro and In Silico Study	5
MiR-125b Inhibits Cell Proliferation and Induces Apoptosis in Human Colon Cancer SW480 Cells via Targeting STAT3	5
Network Pharmacology-based Prediction and Verification of Shikonin for Treating Colorectal Cancer	5
Regression of Breast Cancer Metastases Following Treatment with Irradiated SV-BR-1-GM, a GM-CSF Overexpressing Breast Cancer Cell Line: Intellectual Property and Immune Markers of Response	5