OOIR: Observatory of International Research

Papers

(The TQCC of Recent Patents on Anti-Cancer Drug Discovery is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Developments in the Application of 1,2,3-Triazoles in Cancer Treatment	39
Novel Selective Histone Deacetylase 6 (HDAC6) Inhibitors: A Patent Review (2016-2019)	21
Phytochemicals as PI3K/ Akt/ mTOR Inhibitors and Their Role in Breast Cancer Treatment	16
Reposition of the Fungicide Ciclopirox for Cancer Treatment	16
Cancer Immunotherapy - Immune Checkpoint Inhibitors in Hepatocellular Carcinoma	16
Current Advances and Outlook in Gastric Cancer Chemoresistance: A Review	15
Application of Nano Drug Delivery System (NDDS) in Cancer Therapy: A Perspective	14
Effect of PI3K/AKT/mTOR Signaling Pathway on Regulating and Controlling the Anti-Invasion and Metastasis of Hepatoma Cells by Bufalin	14
Potential Therapeutic Targets of Curcumin, Most Abundant Active Compound of Turmeric Spice: Role in the Management of Various Types of Cancer	13
Current Status and Prospects of Camrelizumab, A Humanized Antibody Against Programmed Cell Death Receptor 1	12
Alkaloids as Anticancer Agents: A Review of Chinese Patents in Recent 5 Years	11
Anti-EGFR-mAb and 5-Fluorouracil Conjugated Polymeric Nanoparticles for Colorectal Cancer	11
Targeting Cancer Stem Cells with Repurposed Drugs to Improve Current Therapies	11
Feasibility of Repurposing Clioquinol for Cancer Therapy	11
Bortezomib – First Therapeutic Proteasome Inhibitor for Cancer Therapy: A Review of Patent Literature	11
Interplay between RNA Methylation Eraser FTO and Writer METTL3 in Renal Clear Cell Carcinoma Patient Survival	10
Distinct Epigenetic Reprogramming, Mitochondrial Patterns, Cellular Morphology, and Cytotoxicity after Bee Venom Treatment	10
In Vitro and In Vivo Evaluation of Novel DTX-Loaded Multifunctional Heparin-Based Polymeric Micelles Targeting Folate Receptors and Endosomes	10
The Patent Landscape of BRAF Target and KRAS Target	9
LINC00936/microRNA-221-3p Regulates Tumor Progression in Ovarian Cancer by Interacting with LAMA3	9
Gefitinib: An Updated Review of its Role in the Cancer Management, its Nanotechnological Interventions, Recent Patents and Clinical Trials	9
The Efficacy and Mechanism of Proteasome Inhibitors in Solid Tumor Treatment	8
Induced Fit Docking and Automated QSAR Studies Reveal the ER-α Inhibitory Activity of Cannabis sativa in Breast Cancer	8
Recent Trend for EGFR-Based and ALK-Based Targets: A Patent Analysis	8
Immunological Mechanism and Clinical Application of PAMP Adjuvants	8

The Molecular Docking of Flavonoids Isolated from Daucus carota as a Dual Inhibitor of MDM2 and MDMX	8
Repurposing of Metformin for Cancer Therapy: Updated Patent and Literature Review	8
Artificial Intelligence and Cancer Drug Development	8
N6-Methyladenosine-Related RNA Signature Predicting the Prognosis of Ovarian Cancer	8
Anti-Cancer Effect of Melatonin via Downregulation of Delta-like Ligand 4 in Estrogen-Responsive Breast Cancer Cells	7
Self-immolative Linkers in Prodrugs and Antibody Drug Conjugates in Cancer Treatment	7
Repurposing Chloroquine Analogs as an Adjuvant Cancer Therapy	7
Recent Patents on Anti-Cancer Potential of Helenalin	7
Research and Patents Status of Selected Phytochemicals Against Cancer: How Close and How Far?	7
Expression of B Cell Translocation Gene 1 Protein in Colon Carcinoma and its Clinical Significance	7
Imitating Hypoxia and Tumor Microenvironment with Immune Evasion by Employing Three Dimensional In vitro Cellular Models: Impressive Tool in Drug Discovery	7
Natural Product as Substrates of ABC Transporters: A Review	7
High Expression of MYL9 Indicates Poor Clinical Prognosis of Epithelial Ovarian Cancer	7
Pseudo-ginsenoside Rh2 Induces Protective Autophagy in Hepatocellular Carcinoma HepG2 Cells	6
Advancement of Traditional Chinese Medicine in Regulation of Intestinal Flora: Mechanism-based Role in Disease Management	6
Novel Pathways and Mechanisms of Nicotine-Induced Oral Carcinogenesis	6
Anti-cancer Research on Arnebiae radix-derived Naphthoquinone in Recent Five Years	6
Transdermal Drug Delivery: A Step towards Treatment of Cancer	6
The Synthesis, Structural Modification and Mode of Anticancer Action of Evodiamine: A Review	6
Terpenes with Antitumor Activity: A Patent Review	5
Understanding and Targeting the Epigenetic Regulation to Overcome EGFR-TKIs Resistance in Human Cancer	5
Overview of Inorganic Nanoparticles: An Expanding Horizon in Tumor Therapeutics	5
Anti-EGFR Binding Nanobody Delivery System to Improve the Diagnosis and Treatment of Solid Tumours	5
The Impact of Polyphenolics in the Management of Breast Cancer: Mechanistic Aspects and Recent Patents	5
Nano-Based Drug Delivery of Anticancer Chemotherapeutic Drugs Targeting Breast Cancer	5
Antioxidant, Anti-Inflammatory and Anticancer Activities of the Methanolic Extract of Thottea siliquosa: An In Vitro and In Silico Study	5
Daidzein and Chicory Extract Arrest the Cell Cycle via Inhibition of Cyclin D/CDK4 and Cyclin A/CDK2 Gene Expression in Hepatocellular Carcinoma	5
STAT3 Inhibitor Napabucasin Inhibits Tumor Growth and Cooperates with Proteasome Inhibition in Human Ovarian Cancer Cells	5
Modulation of MicroRNAs by Euphorbia Microsciadia Boiss in MDA-MB-231 Cell Line: New Possibilities in Breast Cancer Therapy	5
An Update of Lysine Specific Demethylase 1 Inhibitor: A Patent Review (2016-2020)	5
Prospective Challenges for Patenting and Clinical Trials of Anticancer Compounds from Natural Products: Coherent Review	5
Cancer Stem Cells and their Management in Cancer Therapy	4
Eudragit, a Nifty Polymer for Anticancer Preparations: A Patent Review	4
Lentiviral-Mediated Beclin-1 Overexpression Inhibits Cell Proliferation and Induces Autophagy of Human Esophageal Carcinoma Eca109 Cell Xenograft in Nude Mice	4
Human Saliva Metabolome for Oral Lichen Planus Biomarker Identification	4
A Link Between Chemical Structure and Biological Activity in Triterpenoids	4
Regression of Breast Cancer Metastases Following Treatment with Irradiated SV-BR-1-GM, a GM-CSF Overexpressing Breast Cancer Cell Line: Intellectual Property and Immune Markers of Response	4
pH-responsive Sulfated Hyaluronic Acid Nanoparticles Targeting Tumor Cells and CAFs for the Treatment of Breast Cancer	4
Qigefang Inhibits Migration, Invasion, and Metastasis of ESCC by Inhibiting Gas6/Axl Signaling Pathway	4
Recent Patents on the Development of c-Met Kinase Inhibitors	4
Recent Progress in Natural Anticancer Agents Discovery from Tea (Camellia sinensis): A Review	4
Metallodrugs as Anticancer Chemotherapeutics and Diagnostic Agents: A Critical Patent Review (2010-2020)	4
Downregulation of miRNA-14669 Reverses Vincristine Resistance in Colorectal Cancer Cells through PI3K/AKT Signaling Pathway	4
SOX4 Serves an Oncogenic Role in the Tumourigenesis of Human Breast Adenocarcinoma by Promoting Cell Proliferation, Migration and Inhibiting Apoptosis	4
MiR-125b Inhibits Cell Proliferation and Induces Apoptosis in Human Colon Cancer SW480 Cells via Targeting STAT3	4
Combining PD-1 Inhibitor with VEGF/VEGFR2 Inhibitor in Chemotherapy: Report of a Patient with End-Stage Cholangiocarcinoma and Review of Literature	4
Exploring the Anticancer Potentials of Polyphenols: A Comprehensive Review of Patents in the Last Five Years	4
ZFP36L1 Promotes Gastric Cancer Progression via Regulating JNK and p38 MAPK Signaling Pathways	4
Current Prospects for Adrenocortical Carcinoma Pharmacotherapy	4