Recent Patents on Anti-Cancer Drug Discovery

Papers
(The median citation count of Recent Patents on Anti-Cancer Drug Discovery is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)
ArticleCitations
Acknowledgement to Contributors33
Acknowledgement to Reviewers27
Current Prospects for Adrenocortical Carcinoma Pharmacotherapy26
Comprehensive Genomic Analysis of Puerarin in Inhibiting Bladder Urothelial Carcinoma Cell Proliferation and Migration21
High Expression of MYL9 Indicates Poor Clinical Prognosis of Epithelial Ovarian Cancer20
Interplay between RNA Methylation Eraser FTO and Writer METTL3 in Renal Clear Cell Carcinoma Patient Survival20
Advanced Strategies of CAR-T Cell Therapy in Solid Tumors and Hematological Malignancies20
N6-Methyladenosine-Related RNA Signature Predicting the Prognosis of Ovarian Cancer17
Research Progress on the Anticancer Activity of Plant Polysaccharides16
Statin Use and Hepatocellular Carcinoma Risk: A Comprehensive Meta- Analysis and Systematic Review16
Patent Selections15
Nanomaterials for Diagnosis and Treatment of Lung Cancer: A Review of Recent Patents14
The Prognostic Role of Interferon Gamma-inducible Protein 30 in Clear Cell Renal Cell Carcinoma with Immune Infiltrates14
Bioinformatic Analysis and Experimental Validation of HMGA2-AS1 as a Prognostic Biomarker Associated with Immune Infiltration in Gastric Cancer14
Protective Assessment of Novel (Bncs Formulation) against Brain Tumor14
Santacruzamate A Compositions, Analogs and Methods of Use: A Patent Evaluation of WO 2014/018913 (A2)13
Radiotherapy Enhancing and Radioprotective Properties of Berberine: A Systematic Review13
The Application of Nanotechnology in Immunotherapy based Combinations for Cancer Treatment13
The Present State and Potential Applications of Artificial Intelligence in Cancer Diagnosis and Treatment13
The Anti-Tumor Mechanism and Target of Triptolide Based on Network Pharmacology and Molecular Docking13
Potential Therapeutic Targets of Curcumin, Most Abundant Active Compound of Turmeric Spice: Role in the Management of Various Types of Cancer13
Current Status and Future Perspectives on Old Drug Repurposing for Cancer Treatment12
Prognostic Value of Fatty Acid Metabolism-related Genes in Patients with Bladder Cancer12
Cancer Immunotherapy - Immune Checkpoint Inhibitors in Hepatocellular Carcinoma12
Network Pharmacology-based Prediction and Verification of Shikonin for Treating Colorectal Cancer12
Acknowledgement To Reviewers11
Regulating Lipid Metabolism via Mitochondrial Dynamics in Tongue Squamous Cell Carcinoma Cancer Stem Cells11
Alpha-solanine Anti-tumor Effects in Non-small Cell Lung Cancer Through Regulating the Energy Metabolism Pathway11
USP31 Activates the Wnt/β-catenin Signaling Pathway and Promotes Gastric Cancer Cell Proliferation, Invasion and Migration11
The Causal Effects of Cholelithiasis on Acute Pancreatitis and Pancreatic Cancer: A Large Sample Size Mendelian Randomization Analysis10
Bioinformatics Analysis of Key Genes Associated with Resistance to the Combination of Bevacizumab and Pemetrexed Chemotherapy in Non-small Cell Lung Cancer10
Survival Benefits of Ganoderma Lucidum in Early-stage Triple-negative Breast Cancer: A Real World Study10
Self-immolative Linkers in Prodrugs and Antibody Drug Conjugates in Cancer Treatment10
Bourgeoning Cancer Targets10
Vitexin’s Role in Colon Cancer Apoptosis: AMPK/mTOR Pathway Modulation Explored Through Experimental and Computational Approaches10
Mechanisms of Anti-PD Therapy Resistance in Digestive System Neoplasms9
STAT3 Inhibitor Napabucasin Inhibits Tumor Growth and Cooperates with Proteasome Inhibition in Human Ovarian Cancer Cells9
Reposition of the Fungicide Ciclopirox for Cancer Treatment9
Integrated Single-cell and Bulk RNA Sequencing Analysis Cross Talk between Ferroptosis-related Genes and Prognosis in Oral Cavity Squamous Cell Carcinoma9
Current Status and Prospects of Camrelizumab, A Humanized Antibody Against Programmed Cell Death Receptor 18
Screening of Candidate Inflammatory Markers of Epithelial Cells in Hepatocellular Carcinoma Based on Integration Analysis of TCGA/ICGC Databases and Single-cell Sequencing8
Recent Trend for EGFR-Based and ALK-Based Targets: A Patent Analysis8
Predictive Modelling of Overall Survival in Adult Patients with Primary Diffuse Large B-cell Lymphoma of the Breast Using the Surveillance, Epidemiology, and End Results (SEER) Database8
Patent Selections8
Antioxidant, Anti-Inflammatory and Anticancer Activities of the Methanolic Extract of Thottea siliquosa: An In Vitro and In Silico Study8
Prospective Challenges for Patenting and Clinical Trials of Anticancer Compounds from Natural Products: Coherent Review8
Puerarin: An Anticancer and Anti-Inflammatory Agent7
Targeting the Key Signaling Pathways in Breast Cancer: From Molecular Mechanism to Therapeutic Interventions7
SSPH I, A Novel Anti-cancer Saponin, Inhibits EMT and Invasion and Migration of NSCLC by Suppressing MAPK/ERK1/2 and PI3K/AKT/ mTOR Signaling Pathways7
Intracholecystic Papillary-tubular Neoplasm (ICPN) of the Gallbladder: A Case Report Focusing on an Unexpected Pathological Finding7
Construction and Identification of a Human Colorectal Adenoma Epithelial Cell Line by SV40 Large T-Antigen Transfection7
Anti-EGFR-mAb and 5-Fluorouracil Conjugated Polymeric Nanoparticles for Colorectal Cancer7
Circular RNA NF1-419 Inhibits Proliferation and Induces Apoptosis by Regulating Lipid Metabolism in Astroglioma Cells7
lncRNA H22954 Inhibits Angiogenesis in Acute Myeloid Leukemia through a PDGFA-dependent Mechanism7
Patent Selections7
The m6A Reader IGF2BP2 Promotes Oral Squamous Cell Carcinoma Progression by Maintaining UCA1 Stability7
Meet the Editorial Board Member7
Ubiquitination-related Gene UBTD1 Mediates Poor Prognosis of Colorectal Cancer and Affects Colorectal Cancer Cell Proliferation and Ferroptosis7
Application of Nano Drug Delivery System (NDDS) in Cancer Therapy: A Perspective6
The FJQR Has Synergistic Effect with Fluoropyrimidine in the Maintenance Treatment for HER-2 Negative Gastric Cancer6
Fatty Acid Synthase (FASN): A Patent Review Since 2016-Present6
Preface6
Natural STAT3 Inhibitors for Cancer Treatment: A Comprehensive Literature Review6
The Synergistic Effect of Ruthenium Complex Δ-Ru1 and Doxorubicin in a Mouse Breast Cancer Model6
Advances in the Treatment of Chronic Myeloid Leukemia6
Metallodrugs as Anticancer Chemotherapeutics and Diagnostic Agents: A Critical Patent Review (2010-2020)6
Patent Selections6
Targeted Regulation of Osteoblasts and Osteoclasts in Osteosarcoma Patients by CSF3R Receptor Inhibition of Osteolysis Caused by Tumor Inflammation Based on Transcriptional Spectrum Analysis and Drug 6
Prognostic and Therapeutic Values of Autophagy-related Genes in Triple-negative Breast Cancer6
Immunological Mechanism and Clinical Application of PAMP Adjuvants5
Exploring the Anticancer Potentials of Polyphenols: A Comprehensive Review of Patents in the Last Five Years5
Patent Selections5
A Synergistic Combination of Oleanolic Acid and Apatinib to Enhance Antitumor Effect on Liver Cancer Cells and Protect against Hepatic Injury5
Combining PD-1 Inhibitor with VEGF/VEGFR2 Inhibitor in Chemotherapy: Report of a Patient with End-Stage Cholangiocarcinoma and Review of Literature5
UBE2L3 Suppresses Oxidative Stress-regulated Necroptosis to Accelerate Osteosarcoma Progression5
Investigating the Therapeutic Potential and Molecular Mechanisms of Daphnetin: A Comprehensive Review5
Adverse Effects of Gefitinib on Skin and Colon in a Lung Cancer Mouse Model5
Recent Patent-Based Perspective on Diagnostic and Therapeutic Interventions in Malignant Mesothelioma: Is Drug Repositioning Knocking on the Door?5
Patent Selections4
Patent Selections:4
Daidzein and Chicory Extract Arrest the Cell Cycle via Inhibition of Cyclin D/CDK4 and Cyclin A/CDK2 Gene Expression in Hepatocellular Carcinoma4
Epigallocatechin Gallate Derivative Y6 Reverses Oxaliplatin Resistance in Hepatocellular Carcinoma via Targeting the MiR-338-3p/HIF-1α/TWIST Axis to Inhibit EMT4
Targeting Ferroptosis as a New Approach for Radiation Protection and Mitigation4
LINC00936/microRNA-221-3p Regulates Tumor Progression in Ovarian Cancer by Interacting with LAMA34
pH-responsive Sulfated Hyaluronic Acid Nanoparticles Targeting Tumor Cells and CAFs for the Treatment of Breast Cancer4
Targeting Notch Pathway in Cancer Diagnostics and Therapeutics: An Emerging Approach4
Patents on PARP-1 Inhibitors for the Management of Cancer from 2017-20234
Ribosome-inactivating Protein MAP30 Isolated from Momordica Charantia L. Induces Apoptosis in Hepatocellular Carcinoma Cells4
Strategies for Developing Cancer Theranostics Approaches4
Development of a Novel Lipid Metabolism-related Gene Prognostic Signature for Patients with Colorectal Cancer4
KRAS Pathways: A Potential Gateway for Cancer Therapeutics and Diagnostics4
Structure-Based Virtual Screening Identifying Novel FOXM1 Inhibitors as the Lead Compounds for Glioblastoma4
Exosome-Derived Cargos in Immune Microenvironment in Esophageal Carcinoma: A Mini-Review4
TGF-β Score based on Silico Analysis can Robustly Predict Prognosis and Immunological Characteristics in Lower-grade Glioma: The Evidence from Multicenter Studies4
New 1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-2-phenylisoquinoline-1(2H)-ones as Phosphoinositide 3-kinase Inhibitors for Treating Cancer and Other Diseases3
A Single-Arm, Open-Label, Phase Ib Clinical Study Evaluating the Efficacy and Safety of Durvalumab in Combination with Albumin-Bound Paclitaxel and Carboplatin as Neoadjuvant Therapy for Resectable St3
Differentiation of Acute Leukemia Cells Including Cells with MLL-AF4 Rearrangements Induced by Jiyuan Oridonin A3
Altering Landscape of Cancer Vaccines: Unique Platforms, Research on Therapeutic Applications and Recent Patents3
Eukaryotic Initiation Factor 3C Can Affect the Proliferation and Invasion of Ovarian Cancer by Regulating the p53 Signalling Pathway3
β-estradiol Induces Mitochondrial Apoptosis in Cervical Cancer through the Suppression of AKT/NF-κB Signaling Pathway3
Patent Selections3
Recent Patents of Pharmaceutical Co-Crystals: Product Development on Anti-Cancer Drugs and Beyond3
Meet the Editorial Board Member3
Identification of Breast Cancer Immune-related Prognostic Characteristics in Tumor Microenvironment3
ZFP36L1 Promotes Gastric Cancer Progression via Regulating JNK and p38 MAPK Signaling Pathways3
Adhesin Component Member STAG2 Enhances Cisplatin Tolerance in Colorectal Cancer Cells through the Epithelial-Mesenchymal Transition Pathway3
Green Synthesized Nanoparticles as a Plausible Therapeutic Strategy Against Hepatocellular Carcinoma: An Update on its Preclinical and Clinical Relevance3
Ultrasound-Mediated Cancer Therapeutics Delivery using Micelles and Liposomes: A Review3
Patent Selections3
Antibody-drug Conjugates for Breast Cancer Treatment3
Human Saliva Metabolome for Oral Lichen Planus Biomarker Identification3
The Impact of Polyphenolics in the Management of Breast Cancer: Mechanistic Aspects and Recent Patents2
Updated Progress on Mass Spectrometry Imaging and its Application in Cancer Treatment and Drug Discovery2
Competitive Effect of Overexpressed C-terminal of Snail-1 (CSnail) in Control of the Growth and Metastasis of Melanoma Cells2
1,3,4-Oxadiazoles as Anticancer Agents: A Review2
Metal Nanoparticles as Emerging Drug Candidates in the Management of Cancers and Microbial Infectious Diseases2
Nano-Based Drug Delivery of Anticancer Chemotherapeutic Drugs Targeting Breast Cancer2
Transdermal Drug Delivery: A Step towards Treatment of Cancer2
Meet the Associate Editorial Board Member2
Meet Our Associate Editorial Board Member2
A Combined Bioinformatic and Nanoparticle-Based Study Reveal the Role of ABCG2 in the Drug Resistant Breast Cancer2
Repurposing of Metformin for Cancer Therapy: Updated Patent and Literature Review2
Patent Selections2
Downregulation of miRNA-14669 Reverses Vincristine Resistance in Colorectal Cancer Cells through PI3K/AKT Signaling Pathway2
Patent Selections2
Nanotechnology a Boon for Colorectal Cancer Treatment2
Unveiling miR-1468-5p: A New Prognostic Biomarker and Therapeutic Target in Lung Adenocarcinoma2
The Role of KCNMA1 Expression in Digestive Cancers: A Potential Prognostic Biomarker2
Inhibiting the Activity of ABCG2 by KU55933 in Colorectal Cancer2
Increased SLC7A3 Expression Inhibits Tumor Cell Proliferation and Predicts a Favorable Prognosis in Breast Cancer2
Development and Evaluation of a Novel Hyaluronic Acid and Chitosan-modified Phytosome for Co-delivery of Oxymatrine and Glycyrrhizin for Combination Therapy2
Sema3A Inhibits Osteolytic Bone Metastasis of Non-small Cell Lung Cancer1
West African Medicinal Plant Substances and Molecules Activities Against Viral Hepatitis B and Hepatocellular Carcinoma1
TENT5A Increases Glioma Malignancy and Promotes its Progression1
Recent Progress in Natural Anticancer Agents Discovery from Tea (Camellia sinensis): A Review1
Identification of Immune Infiltration-related Molecular Features in Ovarian Cancer Patients and Experimental Validation of Immune Response Molecular Mechanisms through Integrated WGCNA, Machine Learni1
Next Generation Sequencing in the Management of Leptomeningeal Metastases of Non-Small Cell Lung Cancer: A Case Report and Literature Review1
Neochamaejasmine A Promotes Apoptosis and Cell Cycle Arrest in B16F10 Melanoma Cells via JNK and p38 MAPK Signaling Pathway1
From Multiple Myeloma to Acute Myeloid Leukemia: A Case Report of a 61-year-old Woman after 8 Years of Chemotherapy and Immunotherapy1
The Anti-Proliferative Effect of a Newly-Produced Anti-PSCA-Peptide Antibody by Multiple Bioinformatics Tools, on Prostate Cancer Cells1
Phytochemicals and Nanoparticles in the Modulation of PI3K/Akt/mTOR Kinases and its Implications in the Development and Progression of Gastrointestinal Cancers: A Review of Preclinical and Clinical Ev1
A Link Between Chemical Structure and Biological Activity in Triterpenoids1
The Patent Landscape of BRAF Target and KRAS Target1
Targeting Cancer Stem Cells with Repurposed Drugs to Improve Current Therapies1
The Clinical Significance and Prognostic Value of ALDH1 Expression in Non-small Cell Lung Cancer: A Systematic Review and Meta-analysis1
Selinexor as a Therapeutic Target: Advances in Non-small Cell and Small Cell Lung Cancer Treatment Strategies1
Preclinical Effects of Melatonin on the Development of Ehrlich's Tumor: A Biochemical, Cognitive, and Molecular Approach1
Effect of PI3K/AKT/mTOR Signaling Pathway on Regulating and Controlling the Anti-Invasion and Metastasis of Hepatoma Cells by Bufalin1
Pseudo-ginsenoside Rh2 Induces Protective Autophagy in Hepatocellular Carcinoma HepG2 Cells1
The Non-hodgkin Lymphoma Treatment and Side Effects: A Systematic Review and Meta-analysis1
In Vitro Metabolism of E2, G2: Novel Bile Acid-Coupling Camptothecin Analogues, in Rat Liver Microsomes1
Knockdown of RhoA Expression Reverts Enzalutamide Resistance via the p38 MAPK Pathway in Castration-resistant Prostate Cancer1
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