Recent Patents on Anti-Cancer Drug Discovery

Papers
(The median citation count of Recent Patents on Anti-Cancer Drug Discovery is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)
ArticleCitations
Acknowledgement to Contributors61
Acknowledgement to Reviewers55
ZNF146-Mediated HMGB1-NF-κB Signaling Activation as a Therapeutic Target and Prognostic Biomarker in Osteosarcoma35
Current Prospects for Adrenocortical Carcinoma Pharmacotherapy35
L-Selenomethylselenocysteine Exerts Inhibitory Effects on the Progression of Esophageal Cancer by Targeting the PI3K/AKT Signaling Pathway22
Advanced Strategies of CAR-T Cell Therapy in Solid Tumors and Hematological Malignancies20
Integrated Proteomics and Metabolomics Analysis Provides Insights into Metformin Down-regulating GLUL and SP1 to Inhibit Esophageal Squamous Cell Carcinoma Migration and Invasion20
Patent Selections18
Comprehensive Genomic Analysis of Puerarin in Inhibiting Bladder Urothelial Carcinoma Cell Proliferation and Migration18
Bioinformatic Analysis and Experimental Validation of HMGA2-AS1 as a Prognostic Biomarker Associated with Immune Infiltration in Gastric Cancer18
Research Progress on the Anticancer Activity of Plant Polysaccharides18
Multi-omics Analysis Uncovers TFRC/HMOX1-dependent Ferroptosis Mediating Celastrol’s Anti-invasive/Metastatic Effects on Esophageal Squamous Cell Carcinoma16
Protective Assessment of Novel (BNC Formulation) against Brain Tumor16
Statin Use and Hepatocellular Carcinoma Risk: A Comprehensive Meta-Analysis and Systematic Review16
A Comprehensive Review of Genistein and Chitosan: Mechanistic Foundations, Regulatory Roadmap, and Future Research Directions15
Innovative Therapeutic Strategies for Hormone-sensitive Breast Cancer: A Patent Landscape Review15
The Prognostic Role of Interferon Gamma-inducible Protein 30 in Clear Cell Renal Cell Carcinoma with Immune Infiltrates15
Radiotherapy Enhancing and Radioprotective Properties of Berberine: A Systematic Review15
Nanomaterials for Diagnosis and Treatment of Lung Cancer: A Review of Recent Patents15
The Application of Nanotechnology in Immunotherapy based Combinations for Cancer Treatment14
Network Pharmacology-based Prediction and Verification of Shikonin for Treating Colorectal Cancer14
The Present State and Potential Applications of Artificial Intelligence in Cancer Diagnosis and Treatment14
Oral Metronomic Chemotherapy in Nasopharyngeal Carcinoma with Radiotherapy Interruptions: A Lesson Learned from the Lockdown Due to COVID-1914
Bioinformatics Analysis of Key Genes Associated with Resistance to the Combination of Bevacizumab and Pemetrexed Chemotherapy in Non-small Cell Lung Cancer13
Prognostic Value of Fatty Acid Metabolism-related Genes in Patients with Bladder Cancer13
Patent Selections13
Acknowledgement To Reviewers13
USP31 Activates the Wnt/β-catenin Signaling Pathway and Promotes Gastric Cancer Cell Proliferation, Invasion and Migration13
Alpha-solanine Anti-tumor Effects in Non-small Cell Lung Cancer Through Regulating the Energy Metabolism Pathway13
The Causal Effects of Cholelithiasis on Acute Pancreatitis and Pancreatic Cancer: A Large Sample Size Mendelian Randomization Analysis12
Regulating Lipid Metabolism via Mitochondrial Dynamics in Tongue Squamous Cell Carcinoma Cancer Stem Cells12
Vitexin’s Role in Colon Cancer Apoptosis: AMPK/mTOR Pathway Modulation Explored Through Experimental and Computational Approaches12
Bourgeoning Cancer Targets11
Mechanisms of Anti-PD Therapy Resistance in Digestive System Neoplasms11
Survival Benefits of Ganoderma Lucidum in Early-stage Triple-negative Breast Cancer: A Real World Study11
Prospective Challenges for Patenting and Clinical Trials of Anticancer Compounds from Natural Products: Coherent Review10
Mir-338-3p Increases the Sensitivity to Oxaliplatin via Reversing Epithelialmesenchymal Transition in Hepatocellular Carcinoma Cells10
Integrated Single-cell and Bulk RNA Sequencing Analysis Cross Talk between Ferroptosis-related Genes and Prognosis in Oral Cavity Squamous Cell Carcinoma10
Selenium Supplementation in Children and Adolescents Undergoing Cancer Treatment: An Analysis of the Inflammatory Profile and the Expression of Antioxidant Regulators10
Screening of Candidate Inflammatory Markers of Epithelial Cells in Hepatocellular Carcinoma based on Integration Analysis of TCGA/ICGC Databases and Single-cell Sequencing10
Predictive Modelling of Overall Survival in Adult Patients with Primary Diffuse Large B-cell Lymphoma of the Breast Using the Surveillance, Epidemiology, and End Results (SEER) Database10
Pioneering Paclitaxel Delivery: Next-generation Protein Nanocarriers for Transformative Cancer Therapy10
Meet the Editorial Board Member9
Patent Selections9
Construction and Identification of a Human Colorectal Adenoma Epithelial Cell Line by SV40 Large T-antigen Transfection9
Intracholecystic Papillary-tubular Neoplasm (ICPN) of the Gallbladder: A Case Report Focusing on an Unexpected Pathological Finding9
lncRNA H22954 Inhibits Angiogenesis in Acute Myeloid Leukemia through a PDGFA-dependent Mechanism9
SSPH I, A Novel Anti-cancer Saponin, Inhibits EMT and Invasion and Migration of NSCLC by Suppressing MAPK/ERK1/2 and PI3K/AKT/ mTOR Signaling Pathways8
Acknowledgement to Reviewers8
Targeting the Key Signaling Pathways in Breast Cancer: From Molecular Mechanism to Therapeutic Interventions8
The m 6 A Reader IGF2BP2 Promotes Oral Squamous Cell Carcinoma Progression by Maintaining UCA1 Stability8
Preface7
Application of Nano Drug Delivery System (NDDS) in Cancer Therapy: A Perspective7
Ubiquitination-related Gene UBTD1 Mediates Poor Prognosis of Colorectal Cancer and Affects Colorectal Cancer Cell Proliferation and Ferroptosis7
Puerarin: An Anticancer and Anti-Inflammatory Agent7
Natural STAT3 Inhibitors for Cancer Treatment: A Comprehensive Literature Review7
Aucubin Inhibits Liver Cancer via HMGB1-mediated Inactivation of the PI3K/AKT/mTOR Signaling Pathway6
A Phase I Open-label Study of the Safety, Tolerability, and Pharmacokinetics of NHWD-870 HCl in Patients with Lymphoma and Other Advanced Solid Tumors6
Adverse Effects of Gefitinib on Skin and Colon in a Lung Cancer Mouse Model6
Shengma Biejia Decoction Suppresses Acute Myeloid Leukemia by Regulating Mitochondrial Dynamics through the PI3K/AKT Signaling Pathway6
The FJQR Has Synergistic Effect with Fluoropyrimidine in the Maintenance Treatment for HER-2 Negative Gastric Cancer6
Advances in the Treatment of Chronic Myeloid Leukemia6
Exploring the Anticancer Potentials of Polyphenols: A Comprehensive Review of Patents in the Last Five Years6
Targeted Regulation of Osteoblasts and Osteoclasts in Osteosarcoma Patients by CSF3R Receptor Inhibition of Osteolysis Caused by Tumor Inflammation Based on Transcriptional Spectrum Analysis and Drug 6
The Synergistic Effect of Ruthenium Complex Δ-Ru1 and Doxorubicin in a Mouse Breast Cancer Model6
Prognostic and Therapeutic Values of Autophagy-related Genes in Triple-negative Breast Cancer6
Fatty Acid Synthase (FASN): A Patent Review Since 2016-Present6
A Synergistic Combination of Oleanolic Acid and Apatinib to Enhance Antitumor Effect on Liver Cancer Cells and Protect against Hepatic Injury5
pH-responsive Sulfated Hyaluronic Acid Nanoparticles Targeting Tumor Cells and CAFs for the Treatment of Breast Cancer5
KRAS Pathways: A Potential Gateway for Cancer Therapeutics and Diagnostics5
Patent Selections5
Melanoma Metastasizing to the Breast: A Case Report5
Advancements in Sotorasib: A Comprehensive Review of its Efficacy in Non-small Lung Cancer Treatment5
Development of a Novel Lipid Metabolism-related Gene Prognostic Signature for Patients with Colorectal Cancer5
Targeting Notch Pathway in Cancer Diagnostics and Therapeutics: An Emerging Approach5
Innovations in Diagnosis Immunotherapy and Combination Therapy of Prostate Cancer: A Patent-driven Analysis5
Investigating the Therapeutic Potential and Molecular Mechanisms ofDaphnetin: A Comprehensive Review5
UBE2L3 Suppresses Oxidative Stress-regulated Necroptosis to Accelerate Osteosarcoma Progression5
Morusin Suppresses Pancreatic Cancer Cell Proliferation and Migration by Targeting SLC6A12 to Inhibit NF-κB and β-catenin Signaling Pathways5
LMNB1 and LMNB2 as Prognostic Risk Factors in Hepatocellular Carcinoma: Therapeutic Potential of GSK461364 via Downregulation of LMNB1 and LMNB2 Expression5
Patent Selections5
Nano-carriers based Approaches Loaded with Herbal Bioactive Compounds for the Treatment of Cancer: Recent Updates and Future Prospects4
LINC00936/microRNA-221-3p Regulates Tumor Progression in Ovarian Cancer by Interacting with LAMA34
Daidzein and Chicory Extract Arrest the Cell Cycle via Inhibition of Cyclin D/CDK4 and Cyclin A/CDK2 Gene Expression in Hepatocellular Carcinoma4
Eukaryotic Initiation Factor 3C Can Affect the Proliferation and Invasion of Ovarian Cancer by Regulating the p53 Signalling Pathway4
Exosome-Derived Cargos in Immune Microenvironment in Esophageal Carcinoma: A Mini-Review4
Exploring the Molecular Mechanisms and Biological Effects of CELF2 in the Development of Gastric Cancer4
Ribosome-inactivating Protein MAP30 Isolated from Momordica Charantia L. Induces Apoptosis in Hepatocellular Carcinoma Cells4
Epigallocatechin Gallate Derivative Y 6 Reverses Oxaliplatin Resistance in Hepatocellular Carcinoma via Targeting the MiR-338-3p/HIF-1α/TWIST Axis to4
TGF-β Score based on Silico Analysis can Robustly Predict Prognosis and Immunological Characteristics in Lower-grade Glioma: The Evidence from Multicenter Studies4
Structure-Based Virtual Screening of Novel FOXM1 Inhibitors as Potential Compounds for Glioblastoma Treatment4
Patents on PARP-1 Inhibitors for the Management of Cancer from 2017-20234
Patent Selections4
Altering Landscape of Cancer Vaccines: Unique Platforms, Research on Therapeutic Applications and Recent Patents4
Targeting Ferroptosis as a New Approach for Radiation Protection and Mitigation3
Lomitapide as a Novel Therapeutic Agent in Breast Cancer: Mechanism and Potential Implications3
Green Synthesized Nanoparticles as a Plausible Therapeutic Strategy Against Hepatocellular Carcinoma: An Update on its Preclinical and Clinical Relevance3
Unveiling miR-1468-5p: A New Prognostic Biomarker and Therapeutic Target in Lung Adenocarcinoma3
Nanotechnology a Boon for Colorectal Cancer Treatment3
The Impact of Polyphenolics in the Management of Breast Cancer: Mechanistic Aspects and Recent Patents3
Single-cell and Bulk RNA-Seq Analyses Reveal TOMM7-mediated Multi-cell Death Mechanisms Driving Muscle-invasive Bladder Cancer Progression3
Identification of Breast Cancer Immune-related Prognostic Characteristics in Tumor Microenvironment3
Patent Selections3
A Single-arm, Open-label, Phase Ib Clinical Study Evaluating the Efficacy and Safety of Durvalumab in Combination with Albumin-bound Paclitaxel and Carboplatin as Neoadjuvant Therapy for Resectable St3
Adhesin Component Member STAG2 Enhances Cisplatin Tolerance in Colorectal Cancer Cells through the Epithelial-mesenchymal Transition Pathway3
The Role of KCNMA1 Expression in Digestive Cancers: A Potential Prognostic Biomarker3
Recent Patents of Pharmaceutical Co-Crystals: Product Development on Anti-Cancer Drugs and Beyond3
Meet the Associate Editorial Board Member3
β-estradiol Induces Mitochondrial Apoptosis in Cervical Cancer through the Suppression of AKT/NF-κB Signaling Pathway3
Spatial and Single-cell Multi-omics Approaches Unravel the Genetic and Immunological Landscape of SIRPB1 in Kidney Renal Clear Cell Carcinoma3
ZFP36L1 Promotes Gastric Cancer Progression via Regulating JNK and p38 MAPK Signaling Pathways3
New 1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-2-phenylisoquinoline-1(2H)-ones as Phosphoinositide 3-kinase Inhibitors for Treating Cancer and Other Diseases3
Antibody-drug Conjugates for Breast Cancer Treatment3
Updated Progress on Mass Spectrometry Imaging and its Application in Cancer Treatment and Drug Discovery3
Patent Selections3
Lactylation Plays a Novel Role in the Tumor Microenvironment and its Prognostic Implications for Breast Cancer3
Differentiation of Acute Leukemia Cells Including Cells with MLL-AF4 Rearrangements Induced by Jiyuan Oridonin A3
Strategies for Developing Cancer Theranostics Approaches3
Inhibiting the Activity of ABCG2 by KU55933 in Colorectal Cancer2
Patent Selections2
1,3,4-Oxadiazoles as Anticancer Agents: A Review2
Development and Evaluation of a Novel Hyaluronic Acid and Chitosan-modified Phytosome for Co-delivery of Oxymatrine and Glycyrrhizin for Combination Therapy2
Nano-Based Drug Delivery of Anticancer Chemotherapeutic Drugs Targeting Breast Cancer2
Tracing the Technological Trajectory of CAR-T Cell Therapy in Cancer Treatment through Patent Analysis2
Sema3A Affect Osteolytic Bone Metastasis of Non-small Cell Lung Cancer2
The Non-hodgkin Lymphoma Treatment and Side Effects: A Systematic Review and Meta-analysis2
Preclinical Effects of Melatonin on the Development of Ehrlich's Tumor: A Biochemical, Cognitive, and Molecular Approach2
Dahuang Zhechong Pill Combined with TNS4 Silencing Inhibits the NF-Κb/VEGF Pathway To Slow Down The Progression Of Pancreatic Cancer2
Competitive Effect of Overexpressed C-terminal of Snail-1 (CSnail) in Control of the Growth and Metastasis of Melanoma Cells2
West African Medicinal Plant Substances and Molecules Activities Against Viral Hepatitis B and Hepatocellular Carcinoma2
Identification of Immune Infiltration-related Molecular Features in Ovarian Cancer Patients and Experimental Validation of Immune Response Molecular Mechanisms through Integrated WGCNA, Machine Learni2
TENT5A Increases Glioma Malignancy and Promotes its Progression2
Advances in Artemisinin-based Therapies: Innovations in Synthesis, Drug Delivery, and Expanding Therapeutic Applications2
Metal Nanoparticles as Emerging Drug Candidates in the Management of Cancers and Microbial Infectious Diseases2
Transdermal Drug Delivery: A Step towards Treatment of Cancer2
Phytochemicals and Nanoparticles in the Modulation of PI3K/Akt/mTOR Kinases and its Implications in the Development and Progression of Gastrointestinal Cancers: A Review of Preclinical and Clinical Ev2
Increased SLC7A3 Expression Inhibits Tumor Cell Proliferation and Predicts a Favorable Prognosis in Breast Cancer2
Recent Progress in Natural Anticancer Agents Discovery from Tea (Camellia sinensis): A Review2
From Multiple Myeloma to Acute Myeloid Leukemia: A Case Report of a 61-year-old Woman after 8 Years of Chemotherapy and Immunotherapy2
Neochamaejasmine A Promotes Apoptosis and Cell Cycle Arrest in B16F10 Melanoma Cells via JNK and p38 MAPK Signaling Pathway2
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