Cancer Biomarkers

Article	Citations
Circulating microRNA-762 upregulation in colorectal cancer may be accompanied by Wnt-1/β-catenin signaling	59
The clinical significance and function of EGFR mutation in TKI treatments of NSCLC patients	54
RAB27B expression in pancreatic cancer is predictive of poor survival but good response to chemotherapy	54
Preoperative albumin-alkaline phosphatase ratio affects the prognosis of patients undergoing hepatocellular carcinoma surgery	33
Individual recombinant repeats of MUC16 display variable binding to CA125 antibodies	29
Involvement of FAM170B-AS1, hsa-miR-1202, and hsa-miR-146a-5p in breast cancer	27
The effect of low-intensity resistance exercise training on Serum tumor biomarkers and quality of life in women with breast cancer: A randomized controlled trial	22
miR-383-5p serves as a tumor suppressor in bladder cancer by suppressing PI3K/AKT signaling pathway	22
Risk stratification of pancreatic cancer by a blood test for apolipoprotein A2-isoforms	22
KIAA1429-mediated RXFP1 attenuates non-small cell lung cancer tumorigenesis via N6-methyladenosine modification	17
KLF5 inhibits the migration and invasion in cervical cancer cell lines by regulating SNAI1	16
Circulating and tissue miR-100 acts as a potential diagnostic biomarker for cervical cancer	15
Methylation of FBN1, SPG20, ITF2, RUNX3, SNCA, MLH1, and SEPT9 genes in circulating cell-free DNA as biomarkers of colorectal cancer	15
Machine learning identifies a 5-serum cytokine panel for the early detection of chronic atrophy gastritis patients	15
GINS2 promotes the progression of human HNSCC by altering RRM2 expression	14
YTHDF1 amplification is correlated with worse outcome and lower immune cell infiltrations in breast cancer	14
Integrative analysis of histone acetyltransferase KAT2A in human cancer	14
Aquaporin-8 is a novel marker for progression of human cervical cancer cells	13
Identification of a novel necroptosis-related LncRNA signature for prognostic prediction and immune response in oral squamous cell carcinoma	13
Erratum to: Annexin A5 overexpression might suppress proliferation and metastasis of human uterine cervical carcinoma cells	13
Impact of the peripheral blood inflammatory indices and modified nomogram-revised risk index on survival of Extranodal Nasal-Type Natural Killer/T-Cell lymphoma	13
Identification of TNFRSF1A as a potential biomarker for osteosarcoma	12
High TCTA expression is an adverse prognostic biomarker in acute myeloid leukemia	12
CHRDL1, NEFH, TAGLN and SYNM as novel diagnostic biomarkers of benign prostatic hyperplasia and prostate cancer	12
US-Japan collaboration: Collaboration across international boundary	12

Multi-omics pan-cancer analysis of monocyte to macrophage differentiation-associated (MMD) and its significance in hepatocellular carcinoma	12
Identification of candidate biomarkers and prognostic analysis of recurrence in colorectal cancer	12
Volume doubling time and radiomic features predict tumor behavior of screen-detected lung cancers	12
TET-2 mutations predict poor outcomes and are associated with unfavorable clinical-biological features in PTCL, not otherwise specified and angioimmunoblastic T-cell lymphoma in Brazilian patients	12
Investigating whether exosomal miR-205-5p derived from tongue squamous cell carcinoma cells stimulates the angiogenic activity of HUVECs by targeting AMOT	12
Analysis of clinical significance and molecular characteristics of methionine metabolism and macrophage-related patterns in hepatocellular carcinoma based on machine learning	12
From discovery to clinical implementation of a pancreatic blood biomarker, apolipoprotein A2 isoform	11
A pilot study to troubleshoot quality control metrics when assessing circulating miRNA expression data reproducibility across study sites	11
Machine learning reveals the role of telomerase activation-related genes in the prognosis of neuroblastoma	11
Expression of serum HMGB1, SAA, and TSGF in patients with colon cancer and the value of prognostic assessment	11
CPT1B, a metabolic molecule, is also an independent risk factor in CN-AML	11
EGFR, HLA-G, CD70, c-MET, and NY-ESO1 as potential biomarkers in high grade epithelial ovarian carcinoma	10
ELAPOR1 suppresses tumor progression in colorectal cancer and indicates favorable prognosis	10
Albumin-bilirubin score predicts trastuzumab resistance in HER2-positive breast cancer	10
Down-regulated MiRNA 29-b as a diagnostic marker in colorectal cancer and its correlation with ETV4 and Cyclin D1 immunohistochemical expression	10
Assessing the clinical utility of biomarkers using the intervention probability curve (IPC)	10
miRNAs expression pattern and machine learning models elucidate risk for gastric GIST	10
A risk model based on signature genes predicts prognosis and associates with tumor immunity, drug sensitivity in breast cancer	10
Identification and validation of real hub genes in hepatocellular carcinoma based on weighted gene co-expression network analysis	9
E2F1 transcriptionally regulates CCNA2 expression to promote triple negative breast cancer tumorigenicity	9
The combined detection of hematological indicators is used for the differential diagnosis of colorectal cancer and benign-colorectal lesions	9
Identification of prognostic biomarkers among ICAMs in the breast cancer microenvironment	9
Dysregulation of ECRG4 is associated with malignant properties and of prognostic importance in human gastric cancer	9
A novel disulfidptosis-related prognostic gene signature and experimental validation identify ACTN4 as a novel therapeutic target in lung adenocarcinoma	9
TRB CDR3-cancer testis antigen chemical complementarity scoring for identifying productive immune responses in renal cell carcinoma	9
Deep learning approaches for breast cancer detection in histopathology images: A review	9
Lower subcutaneous fat index predicts bone metastasis in breast cancer	9
A simplified MyProstateScore2.0 for high-grade prostate cancer	8
Evaluation of the role of soluble B7-H3 in association with membrane B7-H3 expression in gastric adenocarcinoma	8
Identification of potential core genes at single-cell level contributing to pathogenesis of pancreatic ductal adenocarcinoma through bioinformatics analysis	8
Prognostic value and gene regulatory network of CMSS1 in hepatocellular carcinoma	8
Prognosis of keratinizing squamous cell carcinoma of the female reproductive system: A retrospective study	8
Prognostic characterization of the pyroptosis-related subtypes and tumor microenvironment infiltration in glioma	8
A panel of epigenetically dysregulated Wnt signaling pathway genes for non-invasive diagnosis of pediatric acute lymphoblastic leukemia	8
External validation of CEA and CA125 prediction model for lymph node metastasis in endometrial cancer: A multi-institute cohort study	8
CA125 normalization within 60 days as an independent prognostic factor for patients with advanced epithelial ovarian cancer	8
The prognostic significance of DDIT4 in endometrial cancer	8
Multi-OMICs data analysis identifies molecular features correlating with tumor immunity in colon cancer	8
Prognostic value of ALK overexpression and molecular abnormalities in high-grade serous ovarian carcinoma	7
Comparative proteomic analysis of exhaled breath condensate between lung adenocarcinoma and CT-detected benign pulmonary nodule patients	7
The ratio of lymphocyte/red blood cells and platelets/lymphocytes are predictive biomarkers for lymph node metastasis in patients with breast cancer	7
Personalized statistical learning algorithms to improve the early detection of cancer using longitudinal biomarkers	7
Role of Tim-3 in regulating tumorigenesis, inflammation, and antitumor immunity therapy	7
Retraction to: Schizandrin A inhibits proliferation, migration and invasion of thyroid cancer cell line TPC-1 by down regulation of microRNA-429	7
Knockdown CYP2S1 inhibits lung cancer cells proliferation and migration	7
Association of 21-gene recurrence score and locoregional recurrence in early breast cancer patients	7
Uncovering the link between human endogenous retroviruses, inflammatory pathways, and gastric cancer development	7
Blood endocan as a biomarker for breast cancer recurrence	7
Retraction to: Knockdown of USP39 by lentivirus-mediated RNA interference suppresses the growth of oral squamous cell carcinoma	7
Knockdown of MACC1 expression attenuates colorectal cancer cell glucose metabolism by suppressing GLUT4 membrane translocation	6

Serum CA19-9 as a predictor of incident metabolic syndrome in obese middle-aged and older men: A 9-year cohort study	6
CDT1 facilitates metastasis in prostate cancer and correlates with cell cycle regulation	6
Subcutaneous fat predicts bone metastasis in breast cancer: A novel multimodality-based deep learning model	6
The protein-protein interaction network of intestinal gastric cancer patients reveals hub proteins with potential prognostic value	6
Pan-TRK immunohistochemistry as screening tool for NTRK fusions: A diagnostic workflow for the identification of positive patients in clinical practice	6
Clinical powers of Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 (AIMP1) for head-neck squamous cell carcinoma	6
Assessing the prognostic value of IMDC risk score for nivolumab-treated patients with renal cancer and malignant melanoma	6
The association between pain and WHO grade of pancreatic neuroendocrine neoplasms: A multicenter study	6
Salivary DNA methylation markers for cancer of oral cavity	6
Retraction to: MicroRNA-1246 inhibits cell invasion and epithelial mesenchymal transition process by targeting CXCR4 in lung cancer cells	6
Detection of hypermethylated BCAT1 and IKZF1 DNA in blood and tissues of colorectal, breast and prostate cancer patients	6
CmP signaling network unveils novel biomarkers for triple negative breast cancer in African American women	6
Non-invasive prediction of DCE-MRI radiomics model on CCR5 in breast cancer based on a machine learning algorithm	6
The effect of chromosome abnormalities on expression of SnoRNA in radioresistant and radiosensitive cell lines after irradiation	6
Hypermethylation of the BRCA2 gene promoter and its co-hypermethylation with the BRCA1 gene promoter in patients with breast cancer	6
The miRNA content of circulating exosomes in DLBCL patients and in vitro influence of DLBCL-derived exosomes on miRNA expression of healthy B-cells from peripheral blood	5
Identification of metabolic biomarkers for diagnosis of epithelial ovarian cancer using internal extraction electrospray ionization mass spectrometry (iEESI-MS)	5
Pulmonary adenocarcinoma of low malignant potential defines indolent NSCLC associated with overdiagnosis in the national lung screening trial	5
The prognostic and antitumor roles of key genes of ferroptosis in liver hepatocellular cancer and stomach adenocarcinoma	5
The association between albumin-globulin ratio (AGR) and survival in patients treated with immune checkpoint inhibitors	5
Hsa_circ_0101308 adjusted by N6-methyladenosine (m 6 A) impacts chemo-resistance in cervical cancer via sponging miR-224	5
Relevance of plasma bone marrow Activin-A and CXCL-12 concentration levels as a biomarker in acute myeloid leukemia	5
A new immune-related gene signature predicts the prognosis and immune escape of bladder cancer	5
Prognostic value of an eighteen-genes panel in acute myeloid leukemia by analyzing TARGET and TCGA databases	5
Clinical implication and prognostic significance of FLT3-ITD and ASXL1 mutations in Egyptian AML patients: A single-center study	5
Identification of a prognostic signature based on five ferroptosis-related genes for diffuse large B-cell lymphoma	5
Retraction to: MicroRNA-152 inhibits tumor cell growth while inducing apoptosis via the transcriptional repression of cathepsin L in gastrointestinal stromal tumor	5
Retraction to: LINC01638 lncRNA promotes the proliferation, migration and invasion of prostate carcinoma cells by interacting with Notch1	5
Advances in SEMA3F regulation of clinically high-incidence cancers	5
Internalization of extracellular double-stranded DNA as a potential marker of cancer stem cells in Epstein–Barr virus-induced B-cell lymphoma	5
Upregulated mitosis-associated genes CENPE, CENPF, and DLGAP5 predict poor prognosis and chemotherapy resistance of Acute Myeloid Leukemia	5
The importance of biglycan, decorin and TGF-1 levels in the diagnosis of non-small cell lung cancer	5
Comprehensive analysis of negatively correlated miRNA-mRNA regulatory pairs associated with microsatellite instability in colorectal cancer	5
EMP3: A promising biomarker for tumor prognosis and targeted cancer therapy	4
Lidocaine inhibited migration of NSCLCA549 cells via the CXCR4 regulation	4
Changes in subcellular localization of Lysyl-tRNA synthetase and the 67-kDa laminin receptor in epithelial ovarian cancer metastases	4
RANK in cancer-associated fibroblasts: A valuable prognostic determinant for metastasis in early-stage breast cancer patients	4
Serum aspartate aminotransferase, a novel potential biomarker of prognosis in extranodal natural killer/T cell lymphoma, nasal type	4
Erratum	4
Capillary microsampling-based single-cell metabolomics by mass spectrometry and its applications in medicine and drug discovery	4
Association of miR-21 and miR-335 to microsatellite instability and prognosis in stage III colorectal cancer	4
Immunological function and prognostic value of lymphoid-specific helicase in liver hepatocellular carcinoma	4
SPARC regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma	4
Circulating tumor DNA (ctDNA) as a biomarker of response to therapy in advanced Hepatocellular carcinoma treated with Nivolumab	4
Estimated proportion of cancer deaths not addressed by current cancer screening efforts in the United States	4
Evaluation of CDCP1 (CD318) and endoglin (CD105) expression as prognostic markers in acute myeloid leukemia	4
Impact of detecting plasma EGFR mutations with ultrasensitive liquid biopsy in outcomes of NSCLC patients treated with first- or second-generation EGFR-TKIs	4
Prediction for recurrent non-muscle invasive bladder cancer	4
Identification of RNA-binding protein RBMS3 as a potential biomarker for immunotherapy in bladder cancer	4
Radiomics and artificial intelligence for risk stratification of pulmonary nodules: Ready for primetime?	4
Thresholding of prominent biomarkers of breast cancer on overall survival using classification and regression tree	4
PDGFRB is a potential prognostic biomarker and correlated with immune infiltrates in gastric cancer	4
Targeting PKM2 promotes chemosensitivity of breast cancer cells in vitro and in vivo	4
DNALI1 is a prognosis-related biomarker and correlates with immune infiltrates in low grade glioma	4
Erratum	4
Targeted proteomics for cancer biomarker verification and validation	4
miR-370 is better than miR-375 as a non-invasive diagnostic biomarker for pediatric acute myeloid leukemia patients	4
Elevated expression patterns of P-element Induced Wimpy Testis (PIWI) transcripts are potential candidate markers for Hepatocellular Carcinoma	4
A comprehensive analysis of mRNA expression profiles of Esophageal Squamous Cell Carcinoma reveals downregulation of Desmoglein 1 and crucial genomic targets	4
Expression and clinical significance of TYRP1, ABCB5, and MMP17 in sinonasal mucosal melanoma	4
A novel cuproptosis-related lncRNA signature predicts the prognosis and immunotherapy for hepatocellular carcinoma	4
Clinical significance of “S” isoform of DCLK1 in different gastric cancer subtypes using newly produced monoclonal antibody	4
Diagnostic utility of lipocalin 2 and metalloproteinase 9 levels in early-stage endometrial cancer	4
Detection of leucine-rich alpha-2-glycoprotein 1 containing immunocomplexes in the plasma of lung cancer patients with epitope-specific mAbs	4
Identification of DNA methylation-regulated WEE1 with potential implications in prognosis and immunotherapy for low-grade glioma	4
Construct dysregulated miRNA-mRNA interaction networks to conjecture possible pathogenesis for Stomach adenocarcinomas	4
Genetic polymorphisms of Cathepsin B are associated with gastric cancer risk and prognosis in a Chinese population	4
Differential gene expression analysis for osteosarcoma lung metastases	4
Machine learning methods revealed the roles of immune-metabolism related genes in immune infiltration, stemness, and prognosis of neuroblastoma	3
Exosome-delivered circular RNA DLGAP4 induces chemoresistance via miR-143-HK2 axis in neuroblastoma	3
Polyclonal plasma cell (PolyPC) signature as a key indicator for predicting the progression of MGUS to multiple myeloma	3
Predictive role of HPGD gene in carcinogenesis and immune environment monitoring in human cervical cancer	3
Notice of retraction	3
The predictive potential of Neuronatin for neoadjuvant chemotherapy of breast cancer	3
Effect of D-mannose on Philadelphia chromosome-positive leukemia cells	3
Overexpression of lncRNA TUG1 enhances the efficacy of DC-CIK immunotherapy in neuroblastoma in vitro and in vivo	3
CD133 is an independent predictive and prognostic marker in metastatic breast cancer	3
Microbial biomarker development for detection and prognosis of early-stage non-small cell lung cancer	3
Spatial proteomics and transcriptomics characterization of tissue and multiple cancer types including decalcified marrow	3
Hsa_circ_0002346 inhibits proliferation, invasion, and migration of breast cancer cells and promotes apoptosis: A novel potential biomarker for breast cancer	3

Retraction to: Knockdown of lncRNA CCAT2 inhibits endometrial cancer cells growth and metastasis via sponging miR-216b	3
MicroRNA-204/CREB5 axis regulates vasculogenic mimicry in breast cancer cells	3
A clinical spectrum of resectable lung adenocarcinoma with micropapillary component (MPC) concurrently presenting as mixed ground-glass opacity nodules	3
An integrative approach toward identification and analysis of therapeutic targets involved in HPV pathogenesis with a focus on carcinomas	3
Clinical correlations with EGFR circulating tumor DNA testing in all-stage lung adenocarcinoma	3
Changes in the neutrophil to lymphocyte ratio as predictors of outcome in pediatric patients with central nervous system tumors undergoing surgical resection	3
Exploring lipid metabolism-associated gene biomarkers and their regulatory mechanisms in nasopharyngeal carcinoma	3
Machine learning analyses of highly-multiplexed immunofluorescence identifies distinct tumor and stromal cell populations in primary pancreatic tumors1	3
Bioinformatics analysis of markers based on m6A related to prognosis combined with immune invasion of rectal adenocarcinoma	3
Association of SIRT1 single gene nucleotide polymorphisms and serum SIRT1 levels with laryngeal squamous cell carcinoma patient survival rate	3
Upregulation of MED7 was associated with progression in hepatocellular carcinoma	3
Effects of methylation and imprinting expression of Insulin-like growth factor 2 gene in gastric cancer	3
Expression of CD10 and CD15 in colorectal mucinous and signet ring adenocarcinomas and its relation to clinicopathological features and prognosis	3
lncRNA ARAP1-AS1 enhances proliferation and impairs apoptosis of lymphoma cells by sponging miR-6867-5p	3
Development and validation of machine learning models for early diagnosis and prognosis of lung adenocarcinoma using miRNA expression profiles	3
Prognostic impact of invariant natural killer T cells in solid and hematological tumors; systematic review and meta-analysis	3
AhRR methylation contributes to disease progression in urothelial bladder cancer	3
Predictive value of preoperative inflammatory markers and serum CA 125 level for surgical outcome in Indonesian women with epithelial ovarian cancer	3
Prognostic value of Talin-1 in renal cell carcinoma and its association with B7-H3	3
Aberrant STAT1 methylation as a non-invasive biomarker in blood of HCV induced hepatocellular carcinoma	3
A computed tomography-based score indicative of lung cancer aggression (SILA) predicts lung adenocarcinomas with low malignant potential or vascular invasion	3
Endothelial activation and stress index (EASIX) as a predictive biomarker in small cell lung cancer	3
Multi-omics comprehensive analysis reveals the predictive value of N6-methyladenosine- related genes in prognosis and immune escape of bladder cancer	3
PD-1 inhibitor combined with Docetaxel exerts synergistic anti-prostate cancer effect in mice by down-regulating the expression of PI3K/AKT/NFKB-P65/PD-L1 signaling pathway	3
Erratum	3
The clinical value of a nomogram constructed from CEA, CA199, PT, FIB, tumor differentiation and TNM stage in colorectal cancer	2
Notice of retraction	2
Toll-like receptor 3 is a potential prognosis marker and associated with immune infiltration in stomach adenocarcinoma	2
Diagnostic and prognostic utility of TROP-2, SLP-2, and CXCL12 expression in papillary thyroid carcinoma	2
Identification of immune cell infiltration pattern and related critical genes in metastatic castration-resistant prostate cancer by bioinformatics analysis	2
Systematic exploration of prognostic alternative splicing events related to tumor immune microenvironment of Clear Cell Renal Cell Carcinoma	2
The bioinformatics analysis of CD59 in Helicobacter pylori infected gastric cancer	2
LncRNA STK4 antisense RNA 1 (STK4-AS1) promoted osteosarcoma by inhibiting p53 expression	2
Usefulness of protein-based salivary markers in the diagnosis of oral potentially malignant disorders: A systematic review and meta-analysis	2
Association of endocan expression with clinicopathological prognostic parameters in breast carcinoma	2
Construction of a lncRNA-mediated ceRNA network and a genomic-clinicopathologic nomogram to predict survival for breast cancer patients	2
Plasma checkpoint protein 1 (Chk1) as a potential diagnostic biomarker for opisthorchiasis and cholangiocarcinoma	2
Discrepancies of RET gene and risk of differentiated thyroid carcinoma	2
The tumor microenvironment and prognostic role of autophagy- and immune-related genes in bladder cancer	2
Carboxypeptidase E mRNA: Overexpression predicts recurrence and death in lung adenocarcinoma cancer patients	2
Erratum	2
Comprehensive analysis and establishment of a prognostic model based on non-genetic predictors in multiple myeloma1	2
Suppression effect of a dual cancer-specific oncolytic adenovirus on luciferase-labeled human melanoma cells in vitro and in vivo	2
MKRN1/2 serve as tumor suppressors in renal clear cell carcinoma by regulating the expression of p53	2
Circ_0049271 targets the miR-1197/PTRF axis to attenuate the malignancy of osteosarcoma	2
Identification of Hub genes with prognostic values in colorectal cancer by integrated bioinformatics analysis	2
Profile of soluble factors in pleural effusions predict prognosis in mesothelioma	2
Dynamic changes in practical inflammation and immunity markers in cancer patients receiving immune-enhancing nutritional supplementation during concurrent chemoradiotherapy	2
IGF-1R depletion sensitizes colon cancer cell lines to radiotherapy	2
POM121 promotes proliferation and metastasis in non-small-cell lung cancer through TGF-β/SMAD and PI3K/AKT pathways	2
The change of soluble programmed cell death ligand-1 (sPD-L1): A new predictor of prognosis in hypopharyngeal squamous cell carcinoma patients treated with radiotherapy	2
Combined HPV 16 E2 and L1 methylation predict response to treatment with cidofovir and imiquimod in patients with vulval intraepithelial neoplasia	2
Epigenetically-regulated serum GAS5 as a potential biomarker for patients with chronic hepatitis B virus infection	2
Circulating microRNAs as molecular biomarkers for lung adenocarcinoma	2
Association of single nucleotide polymorphism miRNA-146a (rs2910164) with increased predisposition to oral squamous cell carcinoma in central India population	2
Pan-cancer transcriptomic data of ABI1 transcript variants and molecular constitutive elements identifies novel cancer metastatic and prognostic biomarkers	2
Comparison of CINtec PLUS cytology and cobas HPV test for triaging Canadian patients with LSIL cytology referred to colposcopy: A two-year prospective study	2
Circulating microRNA as potential diagnostic and prognostic biomarkers of well-differentiated thyroid cancer: A review article	2
Urinary VOCs as biomarkers of early stage lung tumour development in mice	2
Biomarkers and potential function analysis of triple-negative breast cancer screening based on bioinformatics	2
Vitamin D receptor polymorphisms associate with the efficacy and toxicity of radioiodine-131 therapy in patients with differentiated thyroid cancer	2
Granzymes expression patterns predict immunotherapy response and identify the heterogeneity of CD8+ T cell subsets	2
MiR-224 promotes lymphatic metastasis by targeting ANGPTL1 in non-small-cell lung carcinoma	2
Integrative genome wide analysis of protein tyrosine phosphatases identifies CDC25C as prognostic and predictive marker for chemoresistance in breast cancer	2
Long non-coding RNAs PTENP1, GNG12-AS1, MAGI2-AS3 and MEG3 as tumor suppressors in breast cancer and their associations with clinicopathological parameters	2
Screening of key methylation-driven genes CDO1 in breast cancer based on WGCNA	2
Rho GTPase-activating protein 4 is upregulated in Kidney Renal Clear Cell Carcinoma and associated with poor prognosis and immune infiltration	2
KIF18A promotes cervical squamous cell carcinoma progression by activating the PI3K/AKT pathway through upregulation of CENPE	2
Bioinformatics screened of biomarkers for the prognosis of hepatocellular carcinoma	2