OOIR: Observatory of International Research

Papers

(The TQCC of Purinergic Signalling is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Some reflections after a long life in science	33
Purinergic P2X7 receptor involves in anti-retinal photodamage effects of berberine	26
The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine	25
Characterization of purinergic signaling in tumor-infiltrating lymphocytes from lower- and high-grade gliomas	23
P2Y12 receptor antagonism inhibits proliferation, migration and leads to autophagy of glioblastoma cells	23
Neuroprotection of exercise: P2X4R and P2X7R regulate BDNF actions	23
Role of the P2X7 receptor in breast cancer progression	22
Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the microglia P2X4R and neuroinflammation	21
Hippocampal astrocytes relieve anxiogenic behavior by increasing, via the release of ATP, excitatory synaptic transmission in dentate gyrus granule cells	21
Promoting glymphatic flow: A non-invasive strategy using 40 Hz light flickering	20
Human plasmacytoid dendritic cells express the functional purinergic halo (CD39/CD73)	19
Moxibustion pre-treatment attenuates seizure severity during status epilepticus and counteracts the proconvulsant function of the purinergic P2X7 receptor	18
P2X7 receptor promotes migration and invasion of non-small cell lung cancer A549 cells through the PI3K/Akt pathways	17
Diadenosine pentaphosphate regulates dendrite growth and number in cultured hippocampal neurons	17
The exploration of active components of 701 Dieda Zhentong patch and analgesic properties on chronic constriction injury rats	17
Correction to: A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes	17
Astrocytic adenosine A2B receptors: a crucial player in brain function	16
ENTPD1 (CD39) and NT5E (CD73) expression in human medulloblastoma: an in silico analysis	15
Second meeting of the Australian and New Zealand Purine Club	14
Macrophage P2Y6 receptor signalling as a key mediator and therapeutic target in atherosclerosis	14
Pharmacological interaction and immune response of purinergic receptors in therapeutic modulation	14
Inhibiting the P2Y13 receptor reduces IL-33 and HMGB1 lung concentrations and inflammatory cell infiltration in a murine model of asthma	14
Purinergic receptors mediate endothelial dysfunction and participate in atherosclerosis	14
Effects of nanoflubendazole and purinergic signaling modulation in overcoming neuroblastoma chemoresistance	14
Editorial: purinergic signalling—perspectives from Australia and New Zealand	14

Electroacupuncture may alleviate inflammatory pain by downregulating the expression of P2Y14 receptor in the primary somatosensory cortex	14
MicroRNA: Crucial modulator in purinergic signalling involved diseases	13
The P2Y2 receptor as a sensor of nucleotides and cell recruitment during inflammatory processes of the liver	13
Pharmacological characterization of P2Y receptor subtypes – an update	13
Purines help determine the gut’s sweet tooth	13
Preface to special issue “A tribute to Maria Teresa Miras-Portugal”	12
Purinergic system in cancer stem cells	12
Pleiotropic effects of clopidogrel	12
May be adenosine an immuno-quorum-sensing signal?	12
Purinergic P2X3 receptors in the carotid body as new therapeutic targets for controlling heart failure	12
Synthesis of new non-natural l-glycosidic flavonoid derivatives and their evaluation as inhibitors of Trypanosoma cruzi ecto-nucleoside triphosphate diphosphohydrolase 1 (TcNTPDase1)	12
Cutaneous melanoma and purinergic modulation by phenolic compounds	11
P2 purinergic receptor dysregulation in urologic disease	11
RETRACTED ARTICLE: Lysophosphatidylcholine induces adenosine release from macrophages via TRPM7-mediated mitochondrial activation	11
NPP1 and TNAP hydrolyze ATP synergistically during biomineralization	11
DUSP1/MKP-1 represents another piece in the P2X7R intracellular signaling puzzle in cerebellar cells: our last journey with Mª Teresa along the purinergic pathways of Eden	10
Crosstalk between P2Y receptors and cyclooxygenase activity in inflammation and tissue repair	10
The anti-inflammatory effect of physical exercise on type 2 diabetes: the role of purinergic signaling	9
P2Y11/IL-1 receptor crosstalk controls macrophage inflammation: a novel target for anti-inflammatory strategies?	9
Ginsenosides enhance P2X7-dependent cytokine secretion from LPS-primed rodent macrophages	9
P2Y6 promoted pruning of FSTL1 nerves by cutaneous macrophages to reset pain threshold and cardiac function	9
Genetic polymorphisms of purinergic P2Y2 receptor were associated with the susceptibility to essential hypertension in Chinese postmenopausal women	8
Partners in health and disease: pineal gland and purinergic signalling	8
Anti-inflammatory and analgesic properties of Polyphyllin VI revealed by network pharmacology and RNA sequencing	8
P2Y11 receptor is a critical regulator of extracellular ATP-mediated premature senescence in lung fibroblasts: Implications of ER-Ca+2 release/mitochondrial ROS production signaling pathway	8
Adenosine receptor signalling in Alzheimer’s disease	8
Identification of novel proteins involved in P2X7-mediated signaling cascades	8
Fluorescent A2A and A3 adenosine receptor antagonists as flow cytometry probes	8
Purinergic P2Y1 and P2Y12 receptors control enteric nervous system activity through neuro-glia-macrophage crosstalk	7
Heterologous expression and biochemical characterization of the recombinant nucleoside triphosphate diphosphohydrolase 2 (LbNTPDase2) from Leishmania (Viannia) braziliensis	7
Correction to: The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia	7
Role and recent progress of P2Y12 receptor in cancer development	7
T cell-derived adenosine regulates fibroblast IL-6 formation via A2B receptors in the infarcted heart	7
Potential role of the P2X7 receptor in the proliferation of human diffused large B-cell lymphoma	7
Editorial—Translation of purinergic drugs into therapeutic use	7
Antagonism of the ATP-gated P2X7 receptor inhibits the proliferation of hepatocellular carcinoma cells	7
P2 purinergic receptor expression and function in tumor-related immune cells	7
Analgesic effect of electroacupuncture on bone cancer pain in rat model: the role of peripheral P2X3 receptor	7
Ectonucleotidases as bridge between the ATP and adenosine world: reflections on Geoffrey Burnstock	6
EU COST Action CA21130 PRESTO ‘P2X receptors as therapeutic targets’ inaugural meeting report	6
Purinergic signaling in liver disease: calcium signaling and induction of inflammation	6
Gallic acid modulates purine metabolism and oxidative stress induced by ethanol exposure in zebrafish brain	6
Announcement of changes to the Editorial Board	6
CD39 in the development and progression of pulmonary arterial hypertension	6
Retraction Note: Modulation of the TGF-β1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells	6
Molecular mechanisms of extracellular-ATP-mediated colorectal cancer progression: Implication of purinergic receptors-mediated nucleocytoplasmic shuttling of HuR	6
Correction to: Purinoceptor: a novel target for hypertension	6
Mechanosensitive release of ATP in the urinary bladder mucosa	6
In vivo phenotypic validation of adenosine receptor-dependent activity of non-adenosine drugs	6