OOIR: Observatory of International Research

Papers

(The TQCC of Purinergic Signalling is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Ectonucleoside triphosphate diphosphohydrolases and ecto-5′-nucleotidase in purinergic signaling: how the field developed and where we are now	46
Involvement of P2X7 receptors in chronic pain disorders	35
Structural basis for the functional properties of the P2X7 receptor for extracellular ATP	32
Antagonism of the ATP-gated P2X7 receptor: a potential therapeutic strategy for cancer	32
Recommended tool compounds and drugs for blocking P2X and P2Y receptors	27
Pannexin 1 as a driver of inflammation and ischemia–reperfusion injury	25
Purinergic signalling in spinal pain processing	23
A novel definition and treatment of hyperinflammation in COVID-19 based on purinergic signalling	23
Purinergic modulation of the immune response to infections	18
Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile	18
Autocrine and paracrine purinergic signaling in the most lethal types of cancer	18
Antidepressant-like effect of guanosine involves activation of AMPA receptor and BDNF/TrkB signaling	17
Purinergic signaling: a potential therapeutic target for depression and chronic pain	16
Targeting the purinergic pathway in breast cancer and its therapeutic applications	16
Mechanisms of ATP release in pain: role of pannexin and connexin channels	16
Exploration of the link between gut microbiota and purinergic signalling	15
Effect of the conditioned medium of mesenchymal stem cells on the expression levels of P2X4 and P2X7 purinergic receptors in the spinal cord of rats with neuropathic pain	15
Effect of P2X purinergic receptors in tumor progression and as a potential target for anti-tumor therapy	15
The role of peripheral adenosine receptors in glutamate-induced pain nociceptive behavior	14
Acupuncture modulates extracellular ATP levels in peripheral sensory nervous system during analgesia of ankle arthritis in rats	14
That was then, this is now: the development of our knowledge and understanding of P2 receptor subtypes	13
To inhibit or to boost the ATP/P2RX7 pathway to fight cancer—that is the question	13
Purinergic receptors mediate endothelial dysfunction and participate in atherosclerosis	13
Novel possibility for cutaneous melanoma treatment by means of rosmarinic acid action on purinergic signaling	13
Pannexin 3 channels in health and disease	13

Cystic fibrosis improves COVID-19 survival and provides clues for treatment of SARS-CoV-2	13
Molecular probes for the human adenosine receptors	12
ATP, an attractive target for the treatment of refractory chronic cough	12
Neutrophils: fast and furious—the nucleotide pathway	12
P2X7 receptor: the regulator of glioma tumor development and survival	12
Targeting the A3 adenosine receptor to treat hepatocellular carcinoma: anti-cancer and hepatoprotective effects	11
The P2X1 receptor as a therapeutic target	11
Dorsal root ganglia P2X4 and P2X7 receptors contribute to diabetes-induced hyperalgesia and the downregulation of electroacupuncture on P2X4 and P2X7	11
Species dependence of A3 adenosine receptor pharmacology and function	11
Influence of NSAIDs and methotrexate on CD73 expression and glioma cell growth	11
A2A adenosine receptor activation prevents neutrophil aging and promotes polarization from N1 towards N2 phenotype	10
P2X7Rs: new therapeutic targets for osteoporosis	10
Adenosine signaling mediate pain transmission in the central nervous system	10
P2X7 receptor activation mediates superoxide dismutase 1 (SOD1) release from murine NSC-34 motor neurons	10
Optimized HPLC method to elucidate the complex purinergic signaling dynamics that regulate ATP, ADP, AMP, and adenosine levels in human blood	10
Adenosine receptor signalling in Alzheimer’s disease	9
Neuroprotection of exercise: P2X4R and P2X7R regulate BDNF actions	9
Inhibition of phosphorylated calcium/calmodulin-dependent protein kinase IIα relieves streptozotocin-induced diabetic neuropathic pain through regulation of P2X3 receptor in dorsal root ganglia	9
Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5′-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives	9
Contribution of P2X4 receptor in pain associated with rheumatoid arthritis: a review	9
Analgesic effect of electroacupuncture on bone cancer pain in rat model: the role of peripheral P2X3 receptor	9
Spinal P2X4 Receptors Involved in Visceral Hypersensitivity of Neonatal Maternal Separation Rats	8
Purinergic signalling in the cardiovascular system—a tribute to Geoffrey Burnstock	8
Pharmacological characterization of DPTN and other selective A3 adenosine receptor antagonists	8
Protective effects of dihydromyricetin on primary hippocampal astrocytes from cytotoxicity induced by comorbid diabetic neuropathic pain and depression	8
The P2 purinoceptors in prostate cancer	8
The real-time detection of acupuncture-induced extracellular ATP mobilization in acupoints and exploration of its role in acupuncture analgesia	8
Enlightening activation gating in P2X receptors	8
Effects of intranasal guanosine administration on brain function in a rat model of ischemic stroke	8
Spinal cord astrocyte P2X7Rs mediate the inhibitory effect of electroacupuncture on visceral hypersensitivity of rat with irritable bowel syndrome	8
The antidepressant-like effect of guanosine involves the modulation of adenosine A1 and A2A receptors	8
Purinergic signaling as a new mechanism underlying physical exercise benefits: a narrative review	8
ATP transporters in the joints	7
Hematopoietic stem cells on the crossroad between purinergic signaling and innate immunity	7
Purinoceptor: a novel target for hypertension	7
Pleiotropic effects of clopidogrel	7
P2X7 receptor promotes migration and invasion of non-small cell lung cancer A549 cells through the PI3K/Akt pathways	7
NPP1 and TNAP hydrolyze ATP synergistically during biomineralization	7
MicroRNA: Crucial modulator in purinergic signalling involved diseases	7
Lack of efficacy of a partial adenosine A1 receptor agonist in neuropathic pain models in mice	7
Purinergic signaling: a potential therapeutic target for ischemic stroke	6
Adenosine A1 and A2A receptors are involved on guanosine protective effects against oxidative burst and mitochondrial dysfunction induced by 6-OHDA in striatal slices	6
Deletion of CD73 increases exercise power in mice	6
The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine	6
Involvement of ectonucleotidases and purinergic receptor expression during acute Chagas disease in the cortex of mice treated with resveratrol and benznidazole	6
P2X7 receptor involved in antitumor activity of atractylenolide I in human cervical cancer cells	6
P2Y1R and P2Y2R: potential molecular triggers in muscle regeneration	6
The history of the Purine Club: a tribute to Prof. Geoffrey Burnstock	6
Involvement of purinergic P2Y1R in antidepressant-like effects of electroacupuncture treatment on social isolation stress mice	6
Adenosine A2A receptors blockade attenuates dexamethasone-induced alterations in cultured astrocytes	6

P2X7 receptor antagonist A-438079 alleviates oxidative stress of lung in LPS-induced septic rats	6
The ATP/P2X7 axis is a crucial regulator of leukemic initiating cells proliferation and homing and an emerging therapeutic target in acute myeloid leukemia	5
P2X7: a receptor with a split personality that raises new hopes for anti-cancer therapy	5
P2Y12 receptor antagonism inhibits proliferation, migration and leads to autophagy of glioblastoma cells	5
Pharmacological characterization of P2Y receptor subtypes – an update	5
Targeting purinergic receptors to attenuate inflammation of dry eye	5
Enhanced expression of P2X4 purinoceptors in pyramidal neurons of the rat hippocampal CA1 region may be involved ischemia-reperfusion injury	5
Extracellular ectonucleotidases are differentially regulated in murine tissues and human polymorphonuclear leukocytes during sepsis and inflammation	5
P2X7-mediated alteration of membrane fluidity is associated with the late stages of age-related macular degeneration	5
Extracellular levels of the sleep homeostasis mediator, adenosine, are regulated by glutamatergic neurons during wakefulness and sleep	5
Role of the extracellular ATP/pyrophosphate metabolism cycle in vascular calcification	5
Gene regulation in activated microglia by adenosine A3 receptor agonists: a transcriptomics study	5
Purinergic signaling in myocardial ischemia–reperfusion injury	5
Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the microglia P2X4R and neuroinflammation	5
Purinergic ATP triggers moxibustion-induced local anti-nociceptive effect on inflammatory pain model	5
Pannexin 1 channels and ATP release in epilepsy: two sides of the same coin	5
Emerging roles of the P2X7 receptor in cancer pain	5