OOIR: Observatory of International Research

Papers

(The TQCC of Purinergic Signalling is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Some reflections after a long life in science	45
Hippocampal astrocytes relieve anxiogenic behavior by increasing, via the release of ATP, excitatory synaptic transmission in dentate gyrus granule cells	37
P2Y12 receptor antagonism inhibits proliferation, migration and leads to autophagy of glioblastoma cells	32
Characterization of purinergic signaling in tumor-infiltrating lymphocytes from lower- and high-grade gliomas	30
Neuroprotection of exercise: P2X4R and P2X7R regulate BDNF actions	29
Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the microglia P2X4R and neuroinflammation	23
The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine	22
Purinergic P2X7 receptor involves in anti-retinal photodamage effects of berberine	21
Role of the P2X7 receptor in breast cancer progression	20
P2X7 receptor promotes migration and invasion of non-small cell lung cancer A549 cells through the PI3K/Akt pathways	19
Promoting glymphatic flow: A non-invasive strategy using 40 Hz light flickering	19
Human plasmacytoid dendritic cells express the functional purinergic halo (CD39/CD73)	19
The exploration of active components of 701 Dieda Zhentong patch and analgesic properties on chronic constriction injury rats	18
Moxibustion pre-treatment attenuates seizure severity during status epilepticus and counteracts the proconvulsant function of the purinergic P2X7 receptor	18
Correction to: A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes	17
Diadenosine pentaphosphate regulates dendrite growth and number in cultured hippocampal neurons	15
Effects of nanoflubendazole and purinergic signaling modulation in overcoming neuroblastoma chemoresistance	15
Astrocytic adenosine A2B receptors: a crucial player in brain function	14
ENTPD1 (CD39) and NT5E (CD73) expression in human medulloblastoma: an in silico analysis	14
Purinergic receptors mediate endothelial dysfunction and participate in atherosclerosis	14
Macrophage P2Y6 receptor signalling as a key mediator and therapeutic target in atherosclerosis	14
Purines help determine the gut’s sweet tooth	13
Editorial: purinergic signalling—perspectives from Australia and New Zealand	13
Purinergic P2X3 receptors in the carotid body as new therapeutic targets for controlling heart failure	13
Electroacupuncture may alleviate inflammatory pain by downregulating the expression of P2Y14 receptor in the primary somatosensory cortex	13

The P2Y2 receptor as a sensor of nucleotides and cell recruitment during inflammatory processes of the liver	13
Inhibiting the P2Y13 receptor reduces IL-33 and HMGB1 lung concentrations and inflammatory cell infiltration in a murine model of asthma	13
Pharmacological interaction and immune response of purinergic receptors in therapeutic modulation	13
MicroRNA: Crucial modulator in purinergic signalling involved diseases	12
Mono-ADP-ribosylation sites of human CD73 inhibit its adenosine-generating enzymatic activity	12
Pharmacological characterization of P2Y receptor subtypes – an update	12
Second meeting of the Australian and New Zealand Purine Club	12
Synthesis of new non-natural l-glycosidic flavonoid derivatives and their evaluation as inhibitors of Trypanosoma cruzi ecto-nucleoside triphosphate diphosphohydrolase 1 (TcNTPDase1)	11
Pharmacological characterization of DPTN and other selective A3 adenosine receptor antagonists	11
NPP1 and TNAP hydrolyze ATP synergistically during biomineralization	11
Pleiotropic effects of clopidogrel	11
Preface to special issue “A tribute to Maria Teresa Miras-Portugal”	11
P2 purinergic receptor dysregulation in urologic disease	11
RETRACTED ARTICLE: Lysophosphatidylcholine induces adenosine release from macrophages via TRPM7-mediated mitochondrial activation	10
May be adenosine an immuno-quorum-sensing signal?	10
Genetic polymorphisms of purinergic P2Y2 receptor were associated with the susceptibility to essential hypertension in Chinese postmenopausal women	10
Purinergic system in cancer stem cells	10
Crosstalk between P2Y receptors and cyclooxygenase activity in inflammation and tissue repair	9
Cutaneous melanoma and purinergic modulation by phenolic compounds	9
DUSP1/MKP-1 represents another piece in the P2X7R intracellular signaling puzzle in cerebellar cells: our last journey with Mª Teresa along the purinergic pathways of Eden	9
P2Y11/IL-1 receptor crosstalk controls macrophage inflammation: a novel target for anti-inflammatory strategies?	9
The role of Pannexin-1 channels and extracellular ATP in the pathogenesis of the human immunodeficiency virus	9
Identification of novel proteins involved in P2X7-mediated signaling cascades	8
P2Y6 promoted pruning of FSTL1 nerves by cutaneous macrophages to reset pain threshold and cardiac function	8
The anti-inflammatory effect of physical exercise on type 2 diabetes: the role of purinergic signaling	8
Adenosine receptor signalling in Alzheimer’s disease	8
Partners in health and disease: pineal gland and purinergic signalling	8
Anti-inflammatory and analgesic properties of Polyphyllin VI revealed by network pharmacology and RNA sequencing	8
Mechanisms of ATP release in pain: role of pannexin and connexin channels	8
Correction to: The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia	8
Ginsenosides enhance P2X7-dependent cytokine secretion from LPS-primed rodent macrophages	8
Potential role of the P2X7 receptor in the proliferation of human diffused large B-cell lymphoma	7
Fluorescent A2A and A3 adenosine receptor antagonists as flow cytometry probes	7
P2Y11 receptor is a critical regulator of extracellular ATP-mediated premature senescence in lung fibroblasts: Implications of ER-Ca+2 release/mitochondrial ROS production signaling pathway	7
Analgesic effect of electroacupuncture on bone cancer pain in rat model: the role of peripheral P2X3 receptor	7
Editorial—Translation of purinergic drugs into therapeutic use	7
Heterologous expression and biochemical characterization of the recombinant nucleoside triphosphate diphosphohydrolase 2 (LbNTPDase2) from Leishmania (Viannia) braziliensis	7
Antagonism of the ATP-gated P2X7 receptor inhibits the proliferation of hepatocellular carcinoma cells	6
Purinergic P2Y1 and P2Y12 receptors control enteric nervous system activity through neuro-glia-macrophage crosstalk	6
Retraction Note: Modulation of the TGF-β1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells	6
T cell-derived adenosine regulates fibroblast IL-6 formation via A2B receptors in the infarcted heart	6
P2 purinergic receptor expression and function in tumor-related immune cells	6
CD39 in the development and progression of pulmonary arterial hypertension	6
Quinacrine is not a vital fluorescent probe for vesicular ATP storage	6
In vivo phenotypic validation of adenosine receptor-dependent activity of non-adenosine drugs	6
Role and recent progress of P2Y12 receptor in cancer development	6
Mechanosensitive release of ATP in the urinary bladder mucosa	5
Gallic acid modulates purine metabolism and oxidative stress induced by ethanol exposure in zebrafish brain	5
Purinergic signaling as a new mechanism underlying physical exercise benefits: a narrative review	5
The enzymatic degradation of ATP to adenosine by microglial CD39 regulates neurovascular coupling and metabolic supply to the brain	5

Correction to: Purinoceptor: a novel target for hypertension	5
Ectonucleotidases as bridge between the ATP and adenosine world: reflections on Geoffrey Burnstock	5
EU COST Action CA21130 PRESTO ‘P2X receptors as therapeutic targets’ inaugural meeting report	5
Purinergic modulation of the immune response to infections	5
Burnstock oration — purinergic signalling in kidney transplantation	5
Purinergic signaling in liver disease: calcium signaling and induction of inflammation	5
Molecular mechanisms of extracellular-ATP-mediated colorectal cancer progression: Implication of purinergic receptors-mediated nucleocytoplasmic shuttling of HuR	5
Transactivation of receptor tyrosine kinases by purinergic P2Y and adenosine receptors	5
The P2Y2 receptor: a new player in taste buds	5
Announcement of changes to the Editorial Board	5