Purinergic Signalling

Article	Citations
Neuroprotection of exercise: P2X4R and P2X7R regulate BDNF actions	42
Characterization of purinergic signaling in tumor-infiltrating lymphocytes from lower- and high-grade gliomas	41
Some reflections after a long life in science	35
Hippocampal astrocytes relieve anxiogenic behavior by increasing, via the release of ATP, excitatory synaptic transmission in dentate gyrus granule cells	33
The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine	30
Purinergic P2X7 receptor involves in anti-retinal photodamage effects of berberine	26
P2Y12 receptor antagonism inhibits proliferation, migration and leads to autophagy of glioblastoma cells	25
Role of the P2X7 receptor in breast cancer progression	23
Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the microglia P2X4R and neuroinflammation	23
Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5′-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives	22
Moxibustion pre-treatment attenuates seizure severity during status epilepticus and counteracts the proconvulsant function of the purinergic P2X7 receptor	20
UTP is a regulator of in vitro and in vivo angiogenic properties of cardiac adipose–derived stem cells	19
P2X7 receptor promotes migration and invasion of non-small cell lung cancer A549 cells through the PI3K/Akt pathways	19
Human plasmacytoid dendritic cells express the functional purinergic halo (CD39/CD73)	17
Promoting glymphatic flow: A non-invasive strategy using 40 Hz light flickering	17
Correction to: A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes	17
The exploration of active components of 701 Dieda Zhentong patch and analgesic properties on chronic constriction injury rats	17
ENTPD5: identification of splicing variants and their impact on cancer survival	16
Electroacupuncture may alleviate inflammatory pain by downregulating the expression of P2Y14 receptor in the primary somatosensory cortex	16
Purinergic receptors mediate endothelial dysfunction and participate in atherosclerosis	16
ENTPD1 (CD39) and NT5E (CD73) expression in human medulloblastoma: an in silico analysis	14
Diadenosine pentaphosphate regulates dendrite growth and number in cultured hippocampal neurons	14
Astrocytic adenosine A2B receptors: a crucial player in brain function	14
Editorial: purinergic signalling—perspectives from Australia and New Zealand	13
Macrophage P2Y6 receptor signalling as a key mediator and therapeutic target in atherosclerosis	13

Pharmacological interaction and immune response of purinergic receptors in therapeutic modulation	13
Effects of nanoflubendazole and purinergic signaling modulation in overcoming neuroblastoma chemoresistance	13
Purinergic P2X3 receptors in the carotid body as new therapeutic targets for controlling heart failure	12
Purines help determine the gut’s sweet tooth	12
The P2Y2 receptor as a sensor of nucleotides and cell recruitment during inflammatory processes of the liver	12
Inhibiting the P2Y13 receptor reduces IL-33 and HMGB1 lung concentrations and inflammatory cell infiltration in a murine model of asthma	12
MicroRNA: Crucial modulator in purinergic signalling involved diseases	12
Pharmacological characterization of P2Y receptor subtypes – an update	11
Pleiotropic effects of clopidogrel	11
Mono-ADP-ribosylation sites of human CD73 inhibit its adenosine-generating enzymatic activity	11
Second meeting of the Australian and New Zealand Purine Club	11
NPP1 and TNAP hydrolyze ATP synergistically during biomineralization	10
Preface to special issue “A tribute to Maria Teresa Miras-Portugal”	10
May be adenosine an immuno-quorum-sensing signal?	10
Pharmacological characterization of DPTN and other selective A3 adenosine receptor antagonists	10
Synthesis of new non-natural l-glycosidic flavonoid derivatives and their evaluation as inhibitors of Trypanosoma cruzi ecto-nucleoside triphosphate diphosphohydrolase 1 (TcNTPDase1)	10
Purinergic system in cancer stem cells	10
Genetic polymorphisms of purinergic P2Y2 receptor were associated with the susceptibility to essential hypertension in Chinese postmenopausal women	9
P2 purinergic receptor dysregulation in urologic disease	9
DUSP1/MKP-1 represents another piece in the P2X7R intracellular signaling puzzle in cerebellar cells: our last journey with Mª Teresa along the purinergic pathways of Eden	9
Purinergic ATP triggers moxibustion-induced local anti-nociceptive effect on inflammatory pain model	9
Cutaneous melanoma and purinergic modulation by phenolic compounds	8
The anti-inflammatory effect of physical exercise on type 2 diabetes: the role of purinergic signaling	8
Ginsenosides enhance P2X7-dependent cytokine secretion from LPS-primed rodent macrophages	8
The role of Pannexin-1 channels and extracellular ATP in the pathogenesis of the human immunodeficiency virus	8
Anti-inflammatory and analgesic properties of Polyphyllin VI revealed by network pharmacology and RNA sequencing	8
P2Y11/IL-1 receptor crosstalk controls macrophage inflammation: a novel target for anti-inflammatory strategies?	8
Crosstalk between P2Y receptors and cyclooxygenase activity in inflammation and tissue repair	8
RETRACTED ARTICLE: Lysophosphatidylcholine induces adenosine release from macrophages via TRPM7-mediated mitochondrial activation	8
Mechanisms of ATP release in pain: role of pannexin and connexin channels	7
Identification of novel proteins involved in P2X7-mediated signaling cascades	7
Editorial—Translation of purinergic drugs into therapeutic use	7
P2Y6 promoted pruning of FSTL1 nerves by cutaneous macrophages to reset pain threshold and cardiac function	7
P2Y11 receptor is a critical regulator of extracellular ATP-mediated premature senescence in lung fibroblasts: Implications of ER-Ca+2 release/mitochondrial ROS production signaling pathway	7
Potential role of the P2X7 receptor in the proliferation of human diffused large B-cell lymphoma	7
Adenosine receptor signalling in Alzheimer’s disease	7
Pannexin 3 channels in health and disease	7
Partners in health and disease: pineal gland and purinergic signalling	7
Quinacrine is not a vital fluorescent probe for vesicular ATP storage	6
Heterologous expression and biochemical characterization of the recombinant nucleoside triphosphate diphosphohydrolase 2 (LbNTPDase2) from Leishmania (Viannia) braziliensis	6
Purinergic P2Y1 and P2Y12 receptors control enteric nervous system activity through neuro-glia-macrophage crosstalk	6
Fluorescent A2A and A3 adenosine receptor antagonists as flow cytometry probes	6
The ATP/P2X7 axis is a crucial regulator of leukemic initiating cells proliferation and homing and an emerging therapeutic target in acute myeloid leukemia	6
T cell-derived adenosine regulates fibroblast IL-6 formation via A2B receptors in the infarcted heart	6
Analgesic effect of electroacupuncture on bone cancer pain in rat model: the role of peripheral P2X3 receptor	6
Role and recent progress of P2Y12 receptor in cancer development	5
CD39 in the development and progression of pulmonary arterial hypertension	5
Purinergic signaling in liver disease: calcium signaling and induction of inflammation	5
EU COST Action CA21130 PRESTO ‘P2X receptors as therapeutic targets’ inaugural meeting report	5
Molecular mechanisms of extracellular-ATP-mediated colorectal cancer progression: Implication of purinergic receptors-mediated nucleocytoplasmic shuttling of HuR	5

Antagonism of the ATP-gated P2X7 receptor inhibits the proliferation of hepatocellular carcinoma cells	5
Retraction Note: Modulation of the TGF-β1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells	5
Ectonucleotidases as bridge between the ATP and adenosine world: reflections on Geoffrey Burnstock	5
Transactivation of receptor tyrosine kinases by purinergic P2Y and adenosine receptors	5
Mechanosensitive release of ATP in the urinary bladder mucosa	5
Correction to: Purinoceptor: a novel target for hypertension	5
P2 purinergic receptor expression and function in tumor-related immune cells	5
In vivo phenotypic validation of adenosine receptor-dependent activity of non-adenosine drugs	5
Announcement of changes to the Editorial Board	5
Purinergic signaling as a new mechanism underlying physical exercise benefits: a narrative review	5
Gallic acid modulates purine metabolism and oxidative stress induced by ethanol exposure in zebrafish brain	5
Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile	5
Purinergic modulation of the immune response to infections	4
Screening herbal and natural product libraries to aid discovery of novel allosteric modulators of human P2X7	4
Purinoceptor: a novel target for hypertension	4
The antidepressant-like effect of guanosine involves the modulation of adenosine A1 and A2A receptors	4
Combined oral contraceptives alter ectonucleotidase and adenosine deaminase activities in peripheral blood cells	4
Purinergic signaling: a potential therapeutic target for depression and chronic pain	4
CD39 activities in the treated acupoints contributed to the analgesic mechanism of acupuncture on arthritis rats	4
P2X receptors in the balance between inflammation and pathogen control in sepsis	4
Gene expression alterations of purinergic signaling components in obesity-associated intestinal low-grade inflammation in type 2 diabetes	4
Burnstock oration — purinergic signalling in kidney transplantation	4
Adenosine signaling mediate pain transmission in the central nervous system	4
Unexpected role of microglia and P2Y12 in the induction of and emergence from anesthesia	4
ATP released from dying cancer cells stimulates P2X4 receptors and mTOR in their neighbors	4
The role of the bladder urothelium as a chemical-neural transducer via purinergic signalling in the rapid defence against bacterial infection	3
Third meeting of the Australian and New Zealand Purine Club	3
Enhanced expression of P2X4 purinoceptors in pyramidal neurons of the rat hippocampal CA1 region may be involved ischemia-reperfusion injury	3
Activation of P2X4 receptors in midbrain cerebrospinal fluid-contacting nucleus leads to mechanical hyperalgesia in chronic constriction injury rats	3
The role of purinergic signaling in acupuncture-mediated relief of neuropathic and inflammatory pain	3
Schwann cells transplantation improves nerve injury and alleviates neuropathic pain in rats	3
The impact of purine nucleosides on neuroplasticity in the adult brain	3
P2Y14 receptors: a new target for treating ulcerative colitis	3
Transcriptomic analysis reveals novel age-independent immunomodulatory proteins as a mode of cerebroprotection in P2X4 receptor knockout mice after ischemic stroke	3
Caffeine reduces viability, induces apoptosis, inhibits migration and modulates the CD39/CD73 axis in metastatic cutaneous melanoma cells	3
Rosmarinic acid modulates purinergic signaling and induces apoptosis in melanoma cells	3
Spinal cord astrocyte P2X7Rs mediate the inhibitory effect of electroacupuncture on visceral hypersensitivity of rat with irritable bowel syndrome	3
A major role for adenosine A2A receptor in the interaction between astrocytes and myelinated neurons: possible implications for the therapy of neurodegenerative disorders	3
The P2X1 receptor as a therapeutic target	3
NT5E gene and CD38 protein as potential prognostic biomarkers for childhood B-acute lymphoblastic leukemia	3
To inhibit or to boost the ATP/P2RX7 pathway to fight cancer—that is the question	3
P2X7 receptor in macrophage polarization and its implications in neuroblastoma tumor behavior	3
Is the regulation by miRNAs of NTPDase1 and ecto-5’-nucleotidase genes involved with the different profiles of breast cancer subtypes?	3
Caffeine plus haloperidol reduces fatigue in an experimental model of Parkinson's disease – a prospective to A2AR-D2R heterodimer antagonism	3
P2X7 receptor involved in antitumor activity of atractylenolide I in human cervical cancer cells	2
Hematopoietic stem cells on the crossroad between purinergic signaling and innate immunity	2
Long non-coding RNA MSTRG.81401 short hairpin RNA relieves diabetic neuropathic pain and behaviors of depression by inhibiting P2X4 receptor expression in type 2 diabetic rats	2
Caffeine: a potential mechanism for anti-obesity	2
P2X7 and P2Y1 receptors in DRG mediate electroacupuncture to inhibit peripheral sensitization in rats with IBS visceral pain	2
Correction to: Regulation of TrkB receptor translocation to lipid rafts by adenosine A2A receptors and its functional implications for BDNF-induced regulation of synaptic plasticity	2
Covalently Binding Adenosine A3 Receptor Agonist ICBM Irreversibly Reduces Voltage-Gated Ca2+ Currents in Dorsal Root Ganglion Neurons	2
ADP as a novel stimulus for NLRP3-inflammasome activation in mice fails to translate to humans	2
A step-by-step protocol based on data mining to explore purinergic signaling in glioblastoma	2
Functional role of P2X7 purinergic receptor in cancer and cancer-related pain	2
Adenosine A2A receptor controls the gateway of the choroid plexus	2
Role of the extracellular ATP/pyrophosphate metabolism cycle in vascular calcification	2
P2 purinergic receptors regulate the progression of colorectal cancer	2
SCH58261 effectively prevents the reduction in excitability of striatal MSNs in mice following 20 h of sleep deprivation	2
Astrocytic P2X7 receptor regulates depressive-like behavioral reactions of mice in response to acute stressful stimulation	2
P2 X 7 receptor is a critical regulator of extracellular ATP-induced profibrotic genes expression in rat kidney: implication of transforming growth factor-β/Smad signaling pathway	2
Differently expression of the metabotropic P2Y receptor family after hypoxia-induced seizures in neonates and seizure suppression via P2Y1 receptor agonism	2
P2X7 receptor is essential for ST36-attenuated cardiac fibrosis upon beta-adrenergic insult	2
P2Y12 receptor-mediated cyclooxygenase 2 (COX-2) expression enhances tumor cell progression in a mouse model of lymphoma	2
Involvement of purinergic signalling in the vasomotor response to hypochlorous acid in porcine coronary artery	2
Structural basis for the functional properties of the P2X7 receptor for extracellular ATP	2
The P2X7 receptor is a target of p53 and regulates haematopoiesis following radiation-induced genotoxic stress	2
Metastasis and angiogenesis in cervical cancer: key aspects of purinergic signaling in platelets and possible therapeutic targets	2
Inhibition of P2X7 receptors by Lu AF27139 diminishes colonic hypersensitivity and CNS prostanoid levels in a rat model of visceral pain	1
How selective antagonists and genetic modification have helped characterise the expression and functions of vascular P2Y receptors	1
First evidence of Tityus confluens Borelli, 1899 (Buthidae) venom altering purine metabolism in rat blood cells	1
P2X7Rs: new therapeutic targets for osteoporosis	1
Purinergic signaling in health: special issue of purines 2022 in Brazil	1
ATP breakdown in plasma of children limits the antimicrobial effectiveness of their neutrophils	1
P2X7 receptors and pannexin1 hemichannels shape presynaptic transmission	1
Chemical biology-based approaches to study adenosine A2A − dopamine D2 receptor heteromers	1
Istradefylline modulates purinergic enzymes and reduces malignancy-associated factors in B16F10 melanoma cells	1
Purines and purinergic receptors in primary tumors of the central nervous system	1
Adenosine A2A receptor null chondrocyte transcriptome resembles that of human osteoarthritic chondrocytes	1
The striatum drives the ergogenic effects of caffeine	1
P2Y12 receptor gene polymorphisms are associated with epilepsy	1

P2X7-mediated alteration of membrane fluidity is associated with the late stages of age-related macular degeneration	1
Purinergic signaling in tanycytes and its contribution to nutritional sensing	1
Maria Teresa Miras Portugal (1948–2021): in memoriam	1
Novel synthesized ionizable lipid for LNP-mediated P2X7siRNA to inhibit migration and induce apoptosis of breast cancer cells	1
Blockage of the adenosine A2B receptor prevents cardiac fibroblasts overgrowth in rats with pulmonary arterial hypertension	1
The P2X7R is a crucial target for Angiotensin II-induced myocardial ferroptosis and remodeling	1
Editorial: Small molecules and biologics for future purinergic therapeutics	1
Correction to: P2 purinergic receptors regulate the progression of colorectal cancer	1
Pannexin 1 as a driver of inflammation and ischemia–reperfusion injury	1
Novel possibility for cutaneous melanoma treatment by means of rosmarinic acid action on purinergic signaling	1
Enlightening activation gating in P2X receptors	1
Spinal P2X4 Receptors Involved in Visceral Hypersensitivity of Neonatal Maternal Separation Rats	1
P2X7 receptor activation mediates superoxide dismutase 1 (SOD1) release from murine NSC-34 motor neurons	1
Electroacupuncture regulates the P2X7R-NLRP3 inflammatory cascade to relieve decreased sensation on ocular surface of type 2 diabetic rats with dry eye	1
P2X7 receptor: the regulator of glioma tumor development and survival	1
Functional role of adenosine via KATP channels in cerebral capillary endothelial cells and pericytes	1
Functional expression of the ATP-gated P2X7 receptor in human iPSC-derived astrocytes	1
Regulation of GABAergic neurotransmission by purinergic receptors in brain physiology and disease	1
Publisher Correction to: Adenosine receptor signalling in Alzheimer’s disease	1
Pharmacological differences between human and mouse P2X4 receptor explored using old and new tools	1
The circadian regulation of extracellular ATP	1
ATP release mediated by pannexin-3 is required for plasma cell survival via P2X4 receptors in bone marrow	1
ENTPD1 (CD39) and NT5E (CD73) expression in human glioblastoma: an in silico analysis	1
CD73 polymorphisms are associated with schizophrenia	1
Purinergic signaling in the peripheral vestibular system	1
Retraction Note: Lysophosphatidylcholine induces adenosine release from macrophages via TRPM7-mediated mitochondrial activation	1
Characterisation of P2Y receptor subtypes mediating vasodilation and vasoconstriction of rat pulmonary artery using selective antagonists	1
Cell cycle regulation by ADP and IGF-1 in cultured late developing glia progenitors of the avian retina	1
Role of ecto-5’-nucleotidase in bladder function activity and smooth muscle contractility	1
ATP, an attractive target for the treatment of refractory chronic cough	1
Preclinical and clinical aspects of P2X receptors as a common route in different diseases: A meeting report	1
A new approach to psoriasis therapy: photoswitchable A3 adenosine receptor activation	1
The real-time detection of acupuncture-induced extracellular ATP mobilization in acupoints and exploration of its role in acupuncture analgesia	1
A2B adenosine receptor signaling and regulation	1
Modulation of osteoblast differentiation and function by the P2X4 receptor	1
Regulation of transcription factor function by purinergic signalling in cardiovascular diseases	1
Reprogramming the tumor microenvironment by targeting cytidine deaminase in pancreatic ductal adenocarcinoma tumors: implications for the role of P2Y6 receptors	1
ATP transporters in the joints	1
Species dependence of A3 adenosine receptor pharmacology and function	1
Microglial purinergic signaling in Alzheimer’s disease	1