Purinergic Signalling

Article	Citations
High expression levels of pyrimidine metabolic rate–limiting enzymes are adverse prognostic factors in lung adenocarcinoma: a study based on The Cancer Genome Atlas and Gene Expression Omnibus dataset	41
Ectonucleoside triphosphate diphosphohydrolases and ecto-5′-nucleotidase in purinergic signaling: how the field developed and where we are now	40
Purinergic signaling as a basis of acupuncture-induced analgesia	34
Involvement of P2X7 receptors in chronic pain disorders	30
Nociceptive signaling of P2X receptors in chronic pain states	28
Antagonism of the ATP-gated P2X7 receptor: a potential therapeutic strategy for cancer	28
Structural basis for the functional properties of the P2X7 receptor for extracellular ATP	27
P2X7 receptor antagonism inhibits tumour growth in human high-grade gliomas	22
Recommended tool compounds and drugs for blocking P2X and P2Y receptors	22
Adult mesenchymal stem cells: is there a role for purine receptors in their osteogenic differentiation?	22
Pannexin 1 as a driver of inflammation and ischemia–reperfusion injury	22
Purinergic signalling in spinal pain processing	21
A novel definition and treatment of hyperinflammation in COVID-19 based on purinergic signalling	20
P2X7 receptor deletion attenuates oxidative stress and liver damage in sepsis	17
Pannexin-1 channel “fuels” by releasing ATP from bone marrow cells a state of sterile inflammation required for optimal mobilization and homing of hematopoietic stem cells	17
Innate immunity orchestrates the mobilization and homing of hematopoietic stem/progenitor cells by engaging purinergic signaling—an update	17
Targeting the purinergic pathway in breast cancer and its therapeutic applications	16
Nucleotide P2Y1 receptor agonists are in vitro and in vivo prodrugs of A1/A3 adenosine receptor agonists: implications for roles of P2Y1 and A1/A3 receptors in physiology and pathology	16
Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile	16
Purinergic signaling: a potential therapeutic target for depression and chronic pain	16
Autocrine and paracrine purinergic signaling in the most lethal types of cancer	15
Purinergic modulation of the immune response to infections	15
Electroacupuncture alleviates diabetic neuropathic pain in rats by suppressing P2X3 receptor expression in dorsal root ganglia	15
The role of peripheral adenosine receptors in glutamate-induced pain nociceptive behavior	14
Adenosine receptors regulate exosome production	14

Antidepressant-like effect of guanosine involves activation of AMPA receptor and BDNF/TrkB signaling	14
To inhibit or to boost the ATP/P2RX7 pathway to fight cancer—that is the question	13
P2X7 is a cytotoxic receptor….maybe not: implications for cancer	13
Effect of P2X purinergic receptors in tumor progression and as a potential target for anti-tumor therapy	13
Design and in vivo activity of A3 adenosine receptor agonist prodrugs	13
Comparison of peripheral blood mononuclear cell isolation techniques and the impact of cryopreservation on human lymphocytes expressing CD39 and CD73	12
That was then, this is now: the development of our knowledge and understanding of P2 receptor subtypes	12
Limonene-induced activation of A2A adenosine receptors reduces airway inflammation and reactivity in a mouse model of asthma	12
Guanosine modulates SUMO2/3-ylation in neurons and astrocytes via adenosine receptors	12
Acupuncture modulates extracellular ATP levels in peripheral sensory nervous system during analgesia of ankle arthritis in rats	11
Cystic fibrosis improves COVID-19 survival and provides clues for treatment of SARS-CoV-2	11
Mechanisms of ATP release in pain: role of pannexin and connexin channels	11
Purinergic receptors mediate endothelial dysfunction and participate in atherosclerosis	11
Pannexin 3 channels in health and disease	11
Molecular probes for the human adenosine receptors	11
Caffeine has a dual influence on NMDA receptor–mediated glutamatergic transmission at the hippocampus	10
Regulation of tumor infiltrated innate immune cells by adenosine	10
P2X7 receptor: the regulator of glioma tumor development and survival	10
Exploration of the link between gut microbiota and purinergic signalling	10
Influence of NSAIDs and methotrexate on CD73 expression and glioma cell growth	10
Characterization of the N6-etheno-bridge method to assess extracellular metabolism of adenine nucleotides: detection of a possible role for purine nucleoside phosphorylase in adenosine metabolism	10
Optimized HPLC method to elucidate the complex purinergic signaling dynamics that regulate ATP, ADP, AMP, and adenosine levels in human blood	9
P2X3 receptors contribute to transition from acute to chronic muscle pain	9
Dorsal root ganglia P2X4 and P2X7 receptors contribute to diabetes-induced hyperalgesia and the downregulation of electroacupuncture on P2X4 and P2X7	9
Involvement of adenosine A1 and A2A receptors on guanosine-mediated anti-tremor effects in reserpinized mice	9
Electroacupuncture improves myocardial ischemia injury via activation of adenosine receptors	9
Novel possibility for cutaneous melanoma treatment by means of rosmarinic acid action on purinergic signaling	9
Inhibition of phosphorylated calcium/calmodulin-dependent protein kinase IIα relieves streptozotocin-induced diabetic neuropathic pain through regulation of P2X3 receptor in dorsal root ganglia	8
Real-time measurement of adenosine and ATP release in the central nervous system	8
Effect of the conditioned medium of mesenchymal stem cells on the expression levels of P2X4 and P2X7 purinergic receptors in the spinal cord of rats with neuropathic pain	8
Pharmacological characterization of DPTN and other selective A3 adenosine receptor antagonists	8
Protective effects of dihydromyricetin on primary hippocampal astrocytes from cytotoxicity induced by comorbid diabetic neuropathic pain and depression	8
Adenosine signaling mediate pain transmission in the central nervous system	8
Purinergic signaling as a new mechanism underlying physical exercise benefits: a narrative review	8
P2X7 receptor activation mediates superoxide dismutase 1 (SOD1) release from murine NSC-34 motor neurons	8
ATP transporters in the joints	7
NPP1 and TNAP hydrolyze ATP synergistically during biomineralization	7
Neutrophils: fast and furious—the nucleotide pathway	7
The P2 purinoceptors in prostate cancer	7
A2A adenosine receptor activation prevents neutrophil aging and promotes polarization from N1 towards N2 phenotype	7
P2X7 siRNA targeted to the kidneys increases klotho and delays the progression of experimental diabetic nephropathy	7
P2X7Rs: new therapeutic targets for osteoporosis	7
ATP, an attractive target for the treatment of refractory chronic cough	7
Contribution of P2X4 receptor in pain associated with rheumatoid arthritis: a review	7
Professor Dr. Geoffrey Burnstock (1929–2020)	7
Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5′-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives	7
The antidepressant-like effect of guanosine involves the modulation of adenosine A1 and A2A receptors	6
The real-time detection of acupuncture-induced extracellular ATP mobilization in acupoints and exploration of its role in acupuncture analgesia	6
Species dependence of A3 adenosine receptor pharmacology and function	6
Involvement of purinergic P2Y1R in antidepressant-like effects of electroacupuncture treatment on social isolation stress mice	6

P2Y1R and P2Y2R: potential molecular triggers in muscle regeneration	6
Analgesic effect of electroacupuncture on bone cancer pain in rat model: the role of peripheral P2X3 receptor	6
Impaired UTP-induced relaxation in the carotid arteries of spontaneously hypertensive rats	6
Purinergic signalling in the cardiovascular system—a tribute to Geoffrey Burnstock	6
The P2X7 ion channel is dispensable for energy and metabolic homeostasis of white and brown adipose tissues	6
Involvement of ectonucleotidases and purinergic receptor expression during acute Chagas disease in the cortex of mice treated with resveratrol and benznidazole	6
P2X7 receptor involved in antitumor activity of atractylenolide I in human cervical cancer cells	6
Effects of intranasal guanosine administration on brain function in a rat model of ischemic stroke	6
Geoffery Burnstock’s influence on the evolution of P2X3 receptor pharmacology	6
Extracellular creatine kinase may modulate purinergic signalling	6
The history of the Purine Club: a tribute to Prof. Geoffrey Burnstock	6
MicroRNA: Crucial modulator in purinergic signalling involved diseases	6
Tribute to Prof. Geoffrey Burnstock: his contribution to acupuncture	6
COVID-19 and purinergic signaling: the need for investigation	6
Purinoceptor: a novel target for hypertension	5
Targeting purinergic receptors to attenuate inflammation of dry eye	5
Deletion of CD73 increases exercise power in mice	5
The ATP/P2X7 axis is a crucial regulator of leukemic initiating cells proliferation and homing and an emerging therapeutic target in acute myeloid leukemia	5
Neuroprotection of exercise: P2X4R and P2X7R regulate BDNF actions	5
Purinergic signaling: a potential therapeutic target for ischemic stroke	5
Deletion of the adenosine A2A receptor increases the survival rate in a mice model of polymicrobial sepsis	5
Enhanced expression of P2X4 purinoceptors in pyramidal neurons of the rat hippocampal CA1 region may be involved ischemia-reperfusion injury	5
Adenosine A2A receptors blockade attenuates dexamethasone-induced alterations in cultured astrocytes	5
Lack of efficacy of a partial adenosine A1 receptor agonist in neuropathic pain models in mice	5
Adenosine receptor signalling in Alzheimer’s disease	5
Enlightening activation gating in P2X receptors	5
Spinal P2X4 Receptors Involved in Visceral Hypersensitivity of Neonatal Maternal Separation Rats	5
Purinergic signaling in myocardial ischemia–reperfusion injury	5
The P2X1 receptor as a therapeutic target	5
Spinal cord astrocyte P2X7Rs mediate the inhibitory effect of electroacupuncture on visceral hypersensitivity of rat with irritable bowel syndrome	5
Adenosine A1 and A2A receptors are involved on guanosine protective effects against oxidative burst and mitochondrial dysfunction induced by 6-OHDA in striatal slices	4
Contribution of Val/Ile87 residue in the extracellular domain in agonist-induced current responses of the human and rat P2X7 receptors	4
The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine	4
The role of Pannexin-1 channels and extracellular ATP in the pathogenesis of the human immunodeficiency virus	4
The circadian regulation of extracellular ATP	4
Mono-ADP-ribosylation sites of human CD73 inhibit its adenosine-generating enzymatic activity	4
Pannexin 1 channels and ATP release in epilepsy: two sides of the same coin	4
Bone phenotype of P2X4 receptor knockout mice: implication of a P2X7 receptor mutation?	4
Extracellular ectonucleotidases are differentially regulated in murine tissues and human polymorphonuclear leukocytes during sepsis and inflammation	4
Extracellular levels of the sleep homeostasis mediator, adenosine, are regulated by glutamatergic neurons during wakefulness and sleep	4
P2Y12 receptor gene polymorphisms are associated with epilepsy	4
Purinergic ATP triggers moxibustion-induced local anti-nociceptive effect on inflammatory pain model	4
Pharmacological characterization of P2Y receptor subtypes – an update	4
Purinergic interplay between erythrocytes and platelets in diabetes-associated vascular dysfunction	4
Purinergic receptor: a crucial regulator of adipose tissue functions	4
Fluorescent A2A and A3 adenosine receptor antagonists as flow cytometry probes	4
P2X7: a receptor with a split personality that raises new hopes for anti-cancer therapy	4
Pleiotropic effects of clopidogrel	4
Hematopoietic stem cells on the crossroad between purinergic signaling and innate immunity	4
P2X7-mediated alteration of membrane fluidity is associated with the late stages of age-related macular degeneration	3
Purinergic signaling in thyroid disease	3
Long non-coding RNA MSTRG.81401 short hairpin RNA relieves diabetic neuropathic pain and behaviors of depression by inhibiting P2X4 receptor expression in type 2 diabetic rats	3
Gene regulation in activated microglia by adenosine A3 receptor agonists: a transcriptomics study	3
Association between the rs3751143 polymorphism of P2RX7 gene and chronic lymphocytic leukemia: A meta-analysis	3
Targeting P2 receptors in purinergic signaling: a new strategy of active ingredients in traditional Chinese herbals for diseases treatment	3
Optical control of purinergic signaling	3
BAC transgenic mice to study the expression of P2X2 and P2Y1 receptors	3
Adenosine A2A receptor controls the gateway of the choroid plexus	3
ENTPD5: identification of splicing variants and their impact on cancer survival	3
Therapeutic potential for P2Y2 receptor antagonism	3
Burnstock and the legacy of the inhibitory junction potential and P2Y1 receptors	3
P2Y11/IL-1 receptor crosstalk controls macrophage inflammation: a novel target for anti-inflammatory strategies?	3
P2 purinergic receptor dysregulation in urologic disease	3
Role of the extracellular ATP/pyrophosphate metabolism cycle in vascular calcification	3
P2X7 receptor promotes migration and invasion of non-small cell lung cancer A549 cells through the PI3K/Akt pathways	3
P2X7 receptor antagonist A-438079 alleviates oxidative stress of lung in LPS-induced septic rats	3
The P2X7 receptor in mucosal adaptive immunity	3
Istradefylline modulates purinergic enzymes and reduces malignancy-associated factors in B16F10 melanoma cells	2
Purinergic signaling in tanycytes and its contribution to nutritional sensing	2
Adenosine A2A receptor null chondrocyte transcriptome resembles that of human osteoarthritic chondrocytes	2
Burnstock oration — purinergic signalling in kidney transplantation	2
Targeting the A3 adenosine receptor to treat hepatocellular carcinoma: anti-cancer and hepatoprotective effects	2
In vivo phenotypic validation of adenosine receptor-dependent activity of non-adenosine drugs	2
A novel mechanism of rotavirus infection involving purinergic signaling	2
Selectivity of the P2X3 receptor antagonist Eliapixant, and its potential use in the treatment of endometriosis	2
Geoffrey Burnstock (1929–2020): the finest pharmacologist and an inspiring scientist	2
P2Y12 receptor antagonism inhibits proliferation, migration and leads to autophagy of glioblastoma cells	2
Pancreatic cancer immune evasion mechanisms: the immunosuppressive role of P2RX1-negative neutrophils	2
Geoffrey Burnstock, our friend and magister: the diadenosine polyphosphate connection	2
Purinergic signaling in the peripheral vestibular system	2

Tribute to Prof. Geoffrey Burnstock: transition of purinergicsignaling to drug discovery	2
Gallic acid modulates purine metabolism and oxidative stress induced by ethanol exposure in zebrafish brain	2
Ectonucleotidases as bridge between the ATP and adenosine world: reflections on Geoffrey Burnstock	2
Fetal bovine serum contains biologically available ATP	2
UTP is a regulator of in vitro and in vivo angiogenic properties of cardiac adipose–derived stem cells	2
The developmental journey of therapies targeting purine receptors: from basic science to clinical trials	2
Modulation of osteoblast differentiation and function by the P2X4 receptor	2
In silico identification of A1 agonists and A2a inhibitors in pain based on molecular docking strategies and dynamics simulations	2
DT-0111: a novel P2X3 receptor antagonist	2
Coffee, adenosine, and the liver	2
Fibroblast growth factor 2 upregulates ecto-5′-nucleotidase and adenosine deaminase via MAPK pathways in cultured rat spinal cord astrocytes	2
Is the regulation by miRNAs of NTPDase1 and ecto-5’-nucleotidase genes involved with the different profiles of breast cancer subtypes?	2
Emerging roles of the P2X7 receptor in cancer pain	2