Purinergic Signalling

Article	Citations
The impact of purine nucleosides on neuroplasticity in the adult brain	35
Extracellular ATP regulates phagocytic activity, mitochondrial respiration, and cytokine secretion of human astrocytic cells	32
Lack of efficacy of a partial adenosine A1 receptor agonist in neuropathic pain models in mice	32
Autocrine and paracrine purinergic signaling in the most lethal types of cancer	29
Editorial: Purinergic signalling — a perspective from China	27
Third meeting of the Australian and New Zealand Purine Club	23
A promising drug for neuropathic pain: identification of vesicular nucleotide transporter as a novel target of eicosapentaenoic acid	19
ATP released from dying cancer cells stimulates P2X4 receptors and mTOR in their neighbors	18
Characterization of purinergic signaling in tumor-infiltrating lymphocytes from lower- and high-grade gliomas	18
NT5E gene and CD38 protein as potential prognostic biomarkers for childhood B-acute lymphoblastic leukemia	18
An introduction to the special issue “The contribution of pannexin-1, connexins and CALHM ATP-release channels to purinergic signalling”	18
The role of the bladder urothelium as a chemical-neural transducer via purinergic signalling in the rapid defence against bacterial infection	17
Editorial-In tribute to Geoff Burnstock	16
Fluorescent A2A and A3 adenosine receptor antagonists as flow cytometry probes	15
Analgesic effect of electroacupuncture on bone cancer pain in rat model: the role of peripheral P2X3 receptor	15
Identification of novel proteins involved in P2X7-mediated signaling cascades	14
A major role for adenosine A2A receptor in the interaction between astrocytes and myelinated neurons: possible implications for the therapy of neurodegenerative disorders	14
Functional role of adenosine via KATP channels in cerebral capillary endothelial cells and pericytes	13
P2Y12 receptor antagonism inhibits proliferation, migration and leads to autophagy of glioblastoma cells	13
P2X7 receptor activation mediates superoxide dismutase 1 (SOD1) release from murine NSC-34 motor neurons	13
Partners in health and disease: pineal gland and purinergic signalling	13
Purinergic P2X7 receptor involves in anti-retinal photodamage effects of berberine	13
Editorial: Small molecules and biologics for future purinergic therapeutics	13
Caffeine plus haloperidol reduces fatigue in an experimental model of Parkinson's disease – a prospective to A2AR-D2R heterodimer antagonism	13
Ectonucleotidase inhibitors: targeting signaling pathways for therapeutic advancement—an in-depth review	12

Effect of chronic maternal L-Glu intake during gestation and/or lactation on oxidative stress markers, AMPA Glu1 receptor and adenosine A1 signalling pathway from foetal and neonatal cerebellum	12
Novel possibility for cutaneous melanoma treatment by means of rosmarinic acid action on purinergic signaling	12
Increasing inosine/decreasing ENT1: promising strategies for anti-obesity therapy	12
Physical exercise as a modulator of the purinergic system in the control of sarcopenia in individuals with chronic kidney disease on hemodialysis	11
Some reflections after a long life in science	11
What strikes most when we think of Geoff	11
P2Y11 receptor is a critical regulator of extracellular ATP-mediated premature senescence in lung fibroblasts: Implications of ER-Ca+2 release/mitochondrial ROS production signaling pathway	10
The P2X7 receptor in mucosal adaptive immunity	10
Potential role of the P2X7 receptor in the proliferation of human diffused large B-cell lymphoma	10
Spinal cord astrocyte P2X7Rs mediate the inhibitory effect of electroacupuncture on visceral hypersensitivity of rat with irritable bowel syndrome	10
Adenosine A2A receptor-bearing GABAergic neurons in the lateral septum of the brain: novel mediators of depressive-like behavior	10
Molecular insights into P2X signalling cascades in acute kidney injury	9
Heterologous expression and biochemical characterization of the recombinant nucleoside triphosphate diphosphohydrolase 2 (LbNTPDase2) from Leishmania (Viannia) braziliensis	9
Targeting P2 receptors in purinergic signaling: a new strategy of active ingredients in traditional Chinese herbals for diseases treatment	9
Schwann cells transplantation improves nerve injury and alleviates neuropathic pain in rats	9
CD73 polymorphisms are associated with schizophrenia	9
Preclinical and clinical aspects of P2X receptors as a common route in different diseases: A meeting report	9
Istradefylline modulates purinergic enzymes and reduces malignancy-associated factors in B16F10 melanoma cells	8
Kinetic profiling of novel spirobenzo-oxazinepiperidinone derivatives as equilibrative nucleoside transporter 1 inhibitors	8
Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5′-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives	8
Role of the P2X7 receptor in breast cancer progression	8
The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine	8
Tumoral P2Y2 receptor modulates tumor growth and host anti-tumor immune responses in a syngeneic murine model of oral cancer	8
Blockage of the adenosine A2B receptor prevents cardiac fibroblasts overgrowth in rats with pulmonary arterial hypertension	8
The P2 purinoceptors in prostate cancer	8
The role of peripheral adenosine receptors in glutamate-induced pain nociceptive behavior	7
Antagonism of the ATP-gated P2X7 receptor: a potential therapeutic strategy for cancer	7
Role of adenosine in the pathophysiology and treatment of attention deficit hyperactivity disorder	7
Hippocampal astrocytes relieve anxiogenic behavior by increasing, via the release of ATP, excitatory synaptic transmission in dentate gyrus granule cells	7
Purines and purinergic receptors in primary tumors of the central nervous system	7
Machine learning-aided search for ligands of P2Y6 and other P2Y receptors	7
Neuroprotection of exercise: P2X4R and P2X7R regulate BDNF actions	7
Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the microglia P2X4R and neuroinflammation	7
Implications of COVID-19 in Parkinson’s disease: the purinergic system in a therapeutic-target perspective to diminish neurodegeneration	6
The developmental journey of therapies targeting purine receptors: from basic science to clinical trials	6
Spinal P2X4 Receptors Involved in Visceral Hypersensitivity of Neonatal Maternal Separation Rats	6
A maestro role of adenosine A2A receptors in GABAergic synapses stabilization during postnatal neuronal maturation	6
The P2X1 receptor as a therapeutic target	6
Exploration of the link between gut microbiota and purinergic signalling	6
Retraction Note: Lysophosphatidylcholine induces adenosine release from macrophages via TRPM7-mediated mitochondrial activation	6
The role of the P2X7 receptor in inactivated SARS-CoV-2-induced lung injury	6
Inhibition of P2X7 receptors by Lu AF27139 diminishes colonic hypersensitivity and CNS prostanoid levels in a rat model of visceral pain	6
P2X7 receptor antagonist A-438079 alleviates oxidative stress of lung in LPS-induced septic rats	6
Activation of P2X4 receptors in midbrain cerebrospinal fluid-contacting nucleus leads to mechanical hyperalgesia in chronic constriction injury rats	5
Engineered yeast-based eATP precisely controlled system for the treatment of inflammatory bowel disease	5
P2X7 receptor: a potential target for treating comorbid anxiety and depression	5
Purinergic regulation of pulmonary vascular tone	5
Bone phenotype of P2X4 receptor knockout mice: implication of a P2X7 receptor mutation?	5
Editorial	5
The adenosine-A2AR-PKA axis in iSPNs: a novel contributor to regulation of locomotion	5

Deletion of CD73 increases exercise power in mice	5
Memories of Prof. Geoffrey Burnstock	5
Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile	5
Role of ecto-5’-nucleotidase in bladder function activity and smooth muscle contractility	5
Caffeine reduces viability, induces apoptosis, inhibits migration and modulates the CD39/CD73 axis in metastatic cutaneous melanoma cells	5
Editorial: Special issue on purinergic signalling and calcification	5
Selectivity of the P2X3 receptor antagonist Eliapixant, and its potential use in the treatment of endometriosis	5
UTP is a regulator of in vitro and in vivo angiogenic properties of cardiac adipose–derived stem cells	5
The exploration of active components of 701 Dieda Zhentong patch and analgesic properties on chronic constriction injury rats	5
P2 purinergic receptor expression and function in tumor-related immune cells	5
The ATP/P2X7 axis is a crucial regulator of leukemic initiating cells proliferation and homing and an emerging therapeutic target in acute myeloid leukemia	5
Assessment of ATP metabolism to adenosine by ecto-nucleotidases carried by tumor-derived small extracellular vesicles	4
P2Y14 receptors: a new target for treating ulcerative colitis	4
Transcriptomic analysis reveals novel age-independent immunomodulatory proteins as a mode of cerebroprotection in P2X4 receptor knockout mice after ischemic stroke	4
Antagonism of the ATP-gated P2X7 receptor inhibits the proliferation of hepatocellular carcinoma cells	4
Extracellular ectonucleotidases are differentially regulated in murine tissues and human polymorphonuclear leukocytes during sepsis and inflammation	4
P2Y1R and P2Y2R: potential molecular triggers in muscle regeneration	4
P2X7 receptors: a bibliometric review from 2002 to 2023	4
Fetal bovine serum contains biologically available ATP	4
Quinacrine is not a vital fluorescent probe for vesicular ATP storage	4
Human plasmacytoid dendritic cells express the functional purinergic halo (CD39/CD73)	4
Purinergic signaling in myocardial ischemia–reperfusion injury	4
Purinergic receptor: a crucial regulator of adipose tissue functions	4
P2X7 receptor promotes migration and invasion of non-small cell lung cancer A549 cells through the PI3K/Akt pathways	3
Consequences of an obesogenic diet can be prevented by knockout of P2Y6 purinergic receptor in mice	3
Geoffrey Burnstock (1929–2020): the finest pharmacologist and an inspiring scientist	3
To inhibit or to boost the ATP/P2RX7 pathway to fight cancer—that is the question	3
Is the regulation by miRNAs of NTPDase1 and ecto-5’-nucleotidase genes involved with the different profiles of breast cancer subtypes?	3
Targeting adenosine A2A receptors for early intervention of retinopathy of prematurity	3
Involvement of P2X7 receptors in chronic pain disorders	3
Emerging roles of the P2X7 receptor in cancer pain	3
Effects of intranasal guanosine administration on brain function in a rat model of ischemic stroke	3
Promoting glymphatic flow: A non-invasive strategy using 40 Hz light flickering	3
Moxibustion pre-treatment attenuates seizure severity during status epilepticus and counteracts the proconvulsant function of the purinergic P2X7 receptor	3
P2X7Rs: new therapeutic targets for osteoporosis	3
A novel definition and treatment of hyperinflammation in COVID-19 based on purinergic signalling	3
Enhanced expression of P2X4 purinoceptors in pyramidal neurons of the rat hippocampal CA1 region may be involved ischemia-reperfusion injury	3
Curcumin modulates purinergic signaling and inflammatory response in cutaneous metastatic melanoma cells	3
Cystic fibrosis improves COVID-19 survival and provides clues for treatment of SARS-CoV-2	3
María Teresa Miras Portugal: a pioneer for vesicular nucleotide storage	3
Therapeutic potential for P2Y2 receptor antagonism	3
Adenosine A2A receptors blockade attenuates dexamethasone-induced alterations in cultured astrocytes	3
Purinergic P2Y1 and P2Y12 receptors control enteric nervous system activity through neuro-glia-macrophage crosstalk	2
Correction to: Preparation and preliminary evaluation of a tritium-labeled allosteric P2X4 receptor antagonist	2
P2X7 receptors and pannexin1 hemichannels shape presynaptic transmission	2
Purinergic interplay between erythrocytes and platelets in diabetes-associated vascular dysfunction	2
Purinergic receptors mediate endothelial dysfunction and participate in atherosclerosis	2
Pharmacological interaction and immune response of purinergic receptors in therapeutic modulation	2
Role and recent progress of P2Y12 receptor in cancer development	2
CD39 in the development and progression of pulmonary arterial hypertension	2
James Saville Wiley (1936–2022): pioneer of purinergic research in Australia and abroad	2
Gallic acid modulates purine metabolism and oxidative stress induced by ethanol exposure in zebrafish brain	2
Diadenosine pentaphosphate regulates dendrite growth and number in cultured hippocampal neurons	2
P2X7 receptor in macrophage polarization and its implications in neuroblastoma tumor behavior	2
Correction to: Role and recent progress of P2Y12 receptor in cancer development	2
Differently expression of the metabotropic P2Y receptor family after hypoxia-induced seizures in neonates and seizure suppression via P2Y1 receptor agonism	2
A novel mechanism of rotavirus infection involving purinergic signaling	2
Chemical biology-based approaches to study adenosine A2A − dopamine D2 receptor heteromers	2
Hematopoietic stem cells on the crossroad between purinergic signaling and innate immunity	1
Pannexin 1 channels and ATP release in epilepsy: two sides of the same coin	1
Molecular mechanisms of extracellular-ATP-mediated colorectal cancer progression: Implication of purinergic receptors-mediated nucleocytoplasmic shuttling of HuR	1
Caffeine: a potential mechanism for anti-obesity	1
Editorial: purinergic signalling—perspectives from Australia and New Zealand	1
Role of the extracellular ATP/pyrophosphate metabolism cycle in vascular calcification	1
Pleiotropic effects of clopidogrel	1
P2X7 receptor involved in antitumor activity of atractylenolide I in human cervical cancer cells	1
The functional role of P2 purinergic receptors in the progression of gastric cancer	1
EU COST Action CA21130 PRESTO ‘P2X receptors as therapeutic targets’ inaugural meeting report	1
Adenosine A1 and A2A receptors are involved on guanosine protective effects against oxidative burst and mitochondrial dysfunction induced by 6-OHDA in striatal slices	1
Correction to: Purinoceptor: a novel target for hypertension	1
In vivo phenotypic validation of adenosine receptor-dependent activity of non-adenosine drugs	1
Retraction Note: Modulation of the TGF-β1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells	1
How selective antagonists and genetic modification have helped characterise the expression and functions of vascular P2Y receptors	1
ENTPD5: identification of splicing variants and their impact on cancer survival	1
Purinergic signaling in liver disease: calcium signaling and induction of inflammation	1
Coffee, adenosine, and the liver	1
Announcement of changes to the Editorial Board	1
ENTPD1 (CD39) and NT5E (CD73) expression in human glioblastoma: an in silico analysis	1
Gene regulation in activated microglia by adenosine A3 receptor agonists: a transcriptomics study	1
Adenosine A2A receptor controls the gateway of the choroid plexus	1

Role of CD73 and the purinergic signaling pathway in the pathogenesis of fusion-negative rhabdomyosarcoma	1
Microglial purinergic signaling in Alzheimer’s disease	1
MicroRNA: Crucial modulator in purinergic signalling involved diseases	1
Influence of NSAIDs and methotrexate on CD73 expression and glioma cell growth	1
Mechanosensitive release of ATP in the urinary bladder mucosa	1
Lessons from the physiological role of guanosine in neurodegeneration and cancer: Toward a multimodal mechanism of action?	1
Electroacupuncture may alleviate inflammatory pain by downregulating the expression of P2Y14 receptor in the primary somatosensory cortex	1
Astrocytic adenosine A2B receptors: a crucial player in brain function	1
Purinergic pathways and their clinical use in the treatment of acute myeloid leukemia	1
Modafinil exerts anti-inflammatory and anti-fibrotic effects by upregulating adenosine A2A and A2B receptors	1
Optimized HPLC method to elucidate the complex purinergic signaling dynamics that regulate ATP, ADP, AMP, and adenosine levels in human blood	1
Neutrophils: fast and furious—the nucleotide pathway	1
Limited contribution of the of P2X4 receptor to LPS-induced microglial reaction in mice	1
Purinergic signaling in the peripheral vestibular system	1
Inhibiting the P2Y13 receptor reduces IL-33 and HMGB1 lung concentrations and inflammatory cell infiltration in a murine model of asthma	1
ENTPD1 (CD39) and NT5E (CD73) expression in human medulloblastoma: an in silico analysis	1
Purinergic P2X3 receptors in the carotid body as new therapeutic targets for controlling heart failure	1
Identifiability of enzyme kinetic parameters in substrate competition: a case study of CD39/NTPDase1	1
Purines help determine the gut’s sweet tooth	1
The role of purinergic signaling in acupuncture-mediated relief of neuropathic and inflammatory pain	1
Ectonucleotidases as bridge between the ATP and adenosine world: reflections on Geoffrey Burnstock	1
Pharmacological differences between human and mouse P2X4 receptor explored using old and new tools	1
Rosmarinic acid modulates purinergic signaling and induces apoptosis in melanoma cells	1
Correction to: The history of the purine Club: a tribute to prof. Geoffrey Burnstock	1
Targeting purinergic receptors to attenuate inflammation of dry eye	1
Identification of purinergic system components in the venom of Bothrops mattogrossensis and the inhibitory effect of specioside extracted from Tabebuia aurea	1
Correction to: A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes	1