Purinergic Signalling

Article	Citations
Ectonucleoside triphosphate diphosphohydrolases and ecto-5′-nucleotidase in purinergic signaling: how the field developed and where we are now	46
Involvement of P2X7 receptors in chronic pain disorders	35
Antagonism of the ATP-gated P2X7 receptor: a potential therapeutic strategy for cancer	32
Structural basis for the functional properties of the P2X7 receptor for extracellular ATP	32
Recommended tool compounds and drugs for blocking P2X and P2Y receptors	27
Pannexin 1 as a driver of inflammation and ischemia–reperfusion injury	25
Purinergic signalling in spinal pain processing	23
A novel definition and treatment of hyperinflammation in COVID-19 based on purinergic signalling	23
Purinergic modulation of the immune response to infections	18
Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile	18
Autocrine and paracrine purinergic signaling in the most lethal types of cancer	18
Antidepressant-like effect of guanosine involves activation of AMPA receptor and BDNF/TrkB signaling	17
Purinergic signaling: a potential therapeutic target for depression and chronic pain	16
Targeting the purinergic pathway in breast cancer and its therapeutic applications	16
Mechanisms of ATP release in pain: role of pannexin and connexin channels	16
Exploration of the link between gut microbiota and purinergic signalling	15
Effect of the conditioned medium of mesenchymal stem cells on the expression levels of P2X4 and P2X7 purinergic receptors in the spinal cord of rats with neuropathic pain	15
Effect of P2X purinergic receptors in tumor progression and as a potential target for anti-tumor therapy	15
Acupuncture modulates extracellular ATP levels in peripheral sensory nervous system during analgesia of ankle arthritis in rats	14
The role of peripheral adenosine receptors in glutamate-induced pain nociceptive behavior	14
Pannexin 3 channels in health and disease	13
Cystic fibrosis improves COVID-19 survival and provides clues for treatment of SARS-CoV-2	13
That was then, this is now: the development of our knowledge and understanding of P2 receptor subtypes	13
To inhibit or to boost the ATP/P2RX7 pathway to fight cancer—that is the question	13
Purinergic receptors mediate endothelial dysfunction and participate in atherosclerosis	13

Novel possibility for cutaneous melanoma treatment by means of rosmarinic acid action on purinergic signaling	13
P2X7 receptor: the regulator of glioma tumor development and survival	12
Molecular probes for the human adenosine receptors	12
ATP, an attractive target for the treatment of refractory chronic cough	12
Neutrophils: fast and furious—the nucleotide pathway	12
Species dependence of A3 adenosine receptor pharmacology and function	11
Influence of NSAIDs and methotrexate on CD73 expression and glioma cell growth	11
Targeting the A3 adenosine receptor to treat hepatocellular carcinoma: anti-cancer and hepatoprotective effects	11
The P2X1 receptor as a therapeutic target	11
Dorsal root ganglia P2X4 and P2X7 receptors contribute to diabetes-induced hyperalgesia and the downregulation of electroacupuncture on P2X4 and P2X7	11
A2A adenosine receptor activation prevents neutrophil aging and promotes polarization from N1 towards N2 phenotype	10
P2X7Rs: new therapeutic targets for osteoporosis	10
Adenosine signaling mediate pain transmission in the central nervous system	10
P2X7 receptor activation mediates superoxide dismutase 1 (SOD1) release from murine NSC-34 motor neurons	10
Optimized HPLC method to elucidate the complex purinergic signaling dynamics that regulate ATP, ADP, AMP, and adenosine levels in human blood	10
Adenosine receptor signalling in Alzheimer’s disease	9
Neuroprotection of exercise: P2X4R and P2X7R regulate BDNF actions	9
Inhibition of phosphorylated calcium/calmodulin-dependent protein kinase IIα relieves streptozotocin-induced diabetic neuropathic pain through regulation of P2X3 receptor in dorsal root ganglia	9
Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5′-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives	9
Contribution of P2X4 receptor in pain associated with rheumatoid arthritis: a review	9
Analgesic effect of electroacupuncture on bone cancer pain in rat model: the role of peripheral P2X3 receptor	9
The antidepressant-like effect of guanosine involves the modulation of adenosine A1 and A2A receptors	8
Purinergic signaling as a new mechanism underlying physical exercise benefits: a narrative review	8
Spinal P2X4 Receptors Involved in Visceral Hypersensitivity of Neonatal Maternal Separation Rats	8
Purinergic signalling in the cardiovascular system—a tribute to Geoffrey Burnstock	8
Pharmacological characterization of DPTN and other selective A3 adenosine receptor antagonists	8
Protective effects of dihydromyricetin on primary hippocampal astrocytes from cytotoxicity induced by comorbid diabetic neuropathic pain and depression	8
The P2 purinoceptors in prostate cancer	8
The real-time detection of acupuncture-induced extracellular ATP mobilization in acupoints and exploration of its role in acupuncture analgesia	8
Enlightening activation gating in P2X receptors	8
Effects of intranasal guanosine administration on brain function in a rat model of ischemic stroke	8
Spinal cord astrocyte P2X7Rs mediate the inhibitory effect of electroacupuncture on visceral hypersensitivity of rat with irritable bowel syndrome	8
NPP1 and TNAP hydrolyze ATP synergistically during biomineralization	7
MicroRNA: Crucial modulator in purinergic signalling involved diseases	7
Lack of efficacy of a partial adenosine A1 receptor agonist in neuropathic pain models in mice	7
ATP transporters in the joints	7
Hematopoietic stem cells on the crossroad between purinergic signaling and innate immunity	7
Purinoceptor: a novel target for hypertension	7
Pleiotropic effects of clopidogrel	7
P2X7 receptor promotes migration and invasion of non-small cell lung cancer A549 cells through the PI3K/Akt pathways	7
P2X7 receptor antagonist A-438079 alleviates oxidative stress of lung in LPS-induced septic rats	6
Purinergic signaling: a potential therapeutic target for ischemic stroke	6
Adenosine A1 and A2A receptors are involved on guanosine protective effects against oxidative burst and mitochondrial dysfunction induced by 6-OHDA in striatal slices	6
Deletion of CD73 increases exercise power in mice	6
The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine	6
Involvement of ectonucleotidases and purinergic receptor expression during acute Chagas disease in the cortex of mice treated with resveratrol and benznidazole	6
P2X7 receptor involved in antitumor activity of atractylenolide I in human cervical cancer cells	6
P2Y1R and P2Y2R: potential molecular triggers in muscle regeneration	6
The history of the Purine Club: a tribute to Prof. Geoffrey Burnstock	6
Involvement of purinergic P2Y1R in antidepressant-like effects of electroacupuncture treatment on social isolation stress mice	6

Adenosine A2A receptors blockade attenuates dexamethasone-induced alterations in cultured astrocytes	6
Pannexin 1 channels and ATP release in epilepsy: two sides of the same coin	5
Emerging roles of the P2X7 receptor in cancer pain	5
The ATP/P2X7 axis is a crucial regulator of leukemic initiating cells proliferation and homing and an emerging therapeutic target in acute myeloid leukemia	5
P2Y12 receptor antagonism inhibits proliferation, migration and leads to autophagy of glioblastoma cells	5
Purinergic ATP triggers moxibustion-induced local anti-nociceptive effect on inflammatory pain model	5
Targeting purinergic receptors to attenuate inflammation of dry eye	5
Enhanced expression of P2X4 purinoceptors in pyramidal neurons of the rat hippocampal CA1 region may be involved ischemia-reperfusion injury	5
Extracellular ectonucleotidases are differentially regulated in murine tissues and human polymorphonuclear leukocytes during sepsis and inflammation	5
P2X7: a receptor with a split personality that raises new hopes for anti-cancer therapy	5
Extracellular levels of the sleep homeostasis mediator, adenosine, are regulated by glutamatergic neurons during wakefulness and sleep	5
Pharmacological characterization of P2Y receptor subtypes – an update	5
Role of the extracellular ATP/pyrophosphate metabolism cycle in vascular calcification	5
Gene regulation in activated microglia by adenosine A3 receptor agonists: a transcriptomics study	5
Purinergic signaling in myocardial ischemia–reperfusion injury	5
Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the microglia P2X4R and neuroinflammation	5
P2X7-mediated alteration of membrane fluidity is associated with the late stages of age-related macular degeneration	5
The role of Pannexin-1 channels and extracellular ATP in the pathogenesis of the human immunodeficiency virus	4
Long non-coding RNA MSTRG.81401 short hairpin RNA relieves diabetic neuropathic pain and behaviors of depression by inhibiting P2X4 receptor expression in type 2 diabetic rats	4
Purinergic interplay between erythrocytes and platelets in diabetes-associated vascular dysfunction	4
Bone phenotype of P2X4 receptor knockout mice: implication of a P2X7 receptor mutation?	4
Fluorescent A2A and A3 adenosine receptor antagonists as flow cytometry probes	4
The circadian regulation of extracellular ATP	4
Adenosine A2A receptor controls the gateway of the choroid plexus	4
Purinergic receptor: a crucial regulator of adipose tissue functions	4
The developmental journey of therapies targeting purine receptors: from basic science to clinical trials	4
P2Y12 receptor gene polymorphisms are associated with epilepsy	4
P2 purinergic receptor dysregulation in urologic disease	4
Mono-ADP-ribosylation sites of human CD73 inhibit its adenosine-generating enzymatic activity	4
Therapeutic potential for P2Y2 receptor antagonism	4
Targeting P2 receptors in purinergic signaling: a new strategy of active ingredients in traditional Chinese herbals for diseases treatment	4
Gallic acid modulates purine metabolism and oxidative stress induced by ethanol exposure in zebrafish brain	3
Istradefylline modulates purinergic enzymes and reduces malignancy-associated factors in B16F10 melanoma cells	3
Modulation of osteoblast differentiation and function by the P2X4 receptor	3
P2Y11/IL-1 receptor crosstalk controls macrophage inflammation: a novel target for anti-inflammatory strategies?	3
ATP breakdown in plasma of children limits the antimicrobial effectiveness of their neutrophils	3
DT-0111: a novel P2X3 receptor antagonist	3
Ectonucleotidases as bridge between the ATP and adenosine world: reflections on Geoffrey Burnstock	3
Selectivity of the P2X3 receptor antagonist Eliapixant, and its potential use in the treatment of endometriosis	3
Antinociceptive and neurochemical effects of a single dose of IB-MECA in chronic pain rat models	3
Purinergic signaling in tanycytes and its contribution to nutritional sensing	3
Burnstock oration — purinergic signalling in kidney transplantation	3
Purinergic signaling in thyroid disease	3
Molecular mechanisms of extracellular-ATP-mediated colorectal cancer progression: Implication of purinergic receptors-mediated nucleocytoplasmic shuttling of HuR	3
ENTPD5: identification of splicing variants and their impact on cancer survival	3
Is the regulation by miRNAs of NTPDase1 and ecto-5’-nucleotidase genes involved with the different profiles of breast cancer subtypes?	3
The striatum drives the ergogenic effects of caffeine	3
Optical control of purinergic signaling	3
In silico identification of A1 agonists and A2a inhibitors in pain based on molecular docking strategies and dynamics simulations	3
BAC transgenic mice to study the expression of P2X2 and P2Y1 receptors	3
Coffee, adenosine, and the liver	3
Adenosine A2A receptor null chondrocyte transcriptome resembles that of human osteoarthritic chondrocytes	2
Covalently Binding Adenosine A3 Receptor Agonist ICBM Irreversibly Reduces Voltage-Gated Ca2+ Currents in Dorsal Root Ganglion Neurons	2
Purinergic signaling in the peripheral vestibular system	2
A novel mechanism of rotavirus infection involving purinergic signaling	2
Fetal bovine serum contains biologically available ATP	2
Inhibition of P2X7 receptors by Lu AF27139 diminishes colonic hypersensitivity and CNS prostanoid levels in a rat model of visceral pain	2
Pancreatic cancer immune evasion mechanisms: the immunosuppressive role of P2RX1-negative neutrophils	2
Rehabilitation of the P2X5 receptor: a re-evaluation of structure and function	2
ENTPD1 (CD39) and NT5E (CD73) expression in human glioblastoma: an in silico analysis	2
Consequences of an obesogenic diet can be prevented by knockout of P2Y6 purinergic receptor in mice	2
UTP is a regulator of in vitro and in vivo angiogenic properties of cardiac adipose–derived stem cells	2
The P2X7 receptor in mucosal adaptive immunity	2
Correction to: Involvement of P2Y12 receptor of stellate ganglion in diabetic cardiovascular autonomic neuropathy	2
Characterisation of P2Y receptor subtypes mediating vasodilation and vasoconstriction of rat pulmonary artery using selective antagonists	2
In vivo phenotypic validation of adenosine receptor-dependent activity of non-adenosine drugs	2
Geoffrey Burnstock (1929–2020): the finest pharmacologist and an inspiring scientist	2
Activation of P2X4 receptors in midbrain cerebrospinal fluid-contacting nucleus leads to mechanical hyperalgesia in chronic constriction injury rats	2
Transactivation of receptor tyrosine kinases by purinergic P2Y and adenosine receptors	1
Modafinil exerts anti-inflammatory and anti-fibrotic effects by upregulating adenosine A2A and A2B receptors	1
Astrocytic adenosine A2B receptors: a crucial player in brain function	1
Gene expression alterations of purinergic signaling components in obesity-associated intestinal low-grade inflammation in type 2 diabetes	1
Limited contribution of the of P2X4 receptor to LPS-induced microglial reaction in mice	1
Maria Teresa Miras Portugal (1948–2021): in memoriam	1
Quinacrine is not a vital fluorescent probe for vesicular ATP storage	1
Crosstalk between P2Y receptors and cyclooxygenase activity in inflammation and tissue repair	1
P2X7 receptor: a potential target for treating comorbid anxiety and depression	1
A maestro role of adenosine A2A receptors in GABAergic synapses stabilization during postnatal neuronal maturation	1
Preparation and preliminary evaluation of a tritium-labeled allosteric P2X4 receptor antagonist	1
Kinetic profiling of novel spirobenzo-oxazinepiperidinone derivatives as equilibrative nucleoside transporter 1 inhibitors	1

Purinergic system in cancer stem cells	1
What strikes most when we think of Geoff	1
P2 X 7 receptor is a critical regulator of extracellular ATP-induced profibrotic genes expression in rat kidney: implication of transforming growth factor-β/Smad signaling pathway	1
Caffeine plus haloperidol reduces fatigue in an experimental model of Parkinson's disease – a prospective to A2AR-D2R heterodimer antagonism	1
A major role for adenosine A2A receptor in the interaction between astrocytes and myelinated neurons: possible implications for the therapy of neurodegenerative disorders	1
The functional role of P2 purinergic receptors in the progression of gastric cancer	1
Pharmacological differences between human and mouse P2X4 receptor explored using old and new tools	1
James Saville Wiley (1936–2022): pioneer of purinergic research in Australia and abroad	1
Cutaneous melanoma and purinergic modulation by phenolic compounds	1
P2X7 receptors and pannexin1 hemichannels shape presynaptic transmission	1
P2X receptors in the balance between inflammation and pathogen control in sepsis	1
Human plasmacytoid dendritic cells express the functional purinergic halo (CD39/CD73)	1
Engineered yeast-based eATP precisely controlled system for the treatment of inflammatory bowel disease	1
Genetic and functional modulation by agonist MRS5698 and allosteric enhancer LUF6000 at the native A3 adenosine receptor in HL-60 cells	1
Machine learning-aided search for ligands of P2Y6 and other P2Y receptors	1
P2 purinergic receptors regulate the progression of colorectal cancer	1
Molecular insights into P2X signalling cascades in acute kidney injury	1
P2X7R: pivotal player in sepsis-induced liver damage	1
Increasing inosine/decreasing ENT1: promising strategies for anti-obesity therapy	1
Feedback facilitation by adenosine A2A receptors of ATP release from mouse hippocampal nerve terminals	1
Functional role of adenosine via KATP channels in cerebral capillary endothelial cells and pericytes	1
NT5E gene and CD38 protein as potential prognostic biomarkers for childhood B-acute lymphoblastic leukemia	1
Second meeting of the Australian and New Zealand Purine Club	1
EU COST Action CA21130 PRESTO ‘P2X receptors as therapeutic targets’ inaugural meeting report	1
Pharmacological interaction and immune response of purinergic receptors in therapeutic modulation	1
CD39 in the development and progression of pulmonary arterial hypertension	1
The role of pyruvate-induced enhancement of oxygen metabolism in extracellular purinergic signaling in the post-cardiac arrest rat model	1
Caffeine reduces viability, induces apoptosis, inhibits migration and modulates the CD39/CD73 axis in metastatic cutaneous melanoma cells	1
Functional expression of the ATP-gated P2X7 receptor in human iPSC-derived astrocytes	1
Purinergic signalling mediates the inhibitory effect of microglia on neuronal activity in the brain	1
Targeting adenosine A2A receptors for early intervention of retinopathy of prematurity	1
Regulation of nerve-evoked contractions of the murine vas deferens	1
Blockage of the adenosine A2B receptor prevents cardiac fibroblasts overgrowth in rats with pulmonary arterial hypertension	1
The P2X7 receptor is a target of p53 and regulates haematopoiesis following radiation-induced genotoxic stress	1
Potential role of the P2X7 receptor in the proliferation of human diffused large B-cell lymphoma	1
A2A receptor signaling drives cisplatin-mediated hippocampal neurotoxicity and cognitive defects in mice	1
Ectonucleotidase inhibitors: targeting signaling pathways for therapeutic advancement—an in-depth review	1
ADP as a novel stimulus for NLRP3-inflammasome activation in mice fails to translate to humans	1
Identification of novel proteins involved in P2X7-mediated signaling cascades	1