OOIR: Observatory of International Research

Papers

(The TQCC of Current Pharmaceutical Analysis is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
UPLC-MS/MS Determination of Chlorogenic Acid, Hyperoside and Astragalin in Plasma and its Pharmacokinetic Application in Liver Injury Rats	54
A Validated LC-MS/MS Method for the Determination of Mezlocillin in Plasma: An Adapted Method for Therapeutic Drug Monitoring in Children	31
Analysis of Shenhuang Capsule using HPLC: Method Development, Validation, and Application	28
Application of a Quantitative Proton Nuclear Magnetic Resonance Method for the Determination of Protopine in Radix Dactylicapnotis	19
Non-enzymatic Glucose Detection by Fe₂O₃ Nanorods-reduced Graphene under Physiological pH	14
Quantitation of Conjugation-related Residual Solvents in Antibody Drug Conjugates using Headspace Gas Chromatography	13
Characteristics, Biological Activities, Synthesis, and Methods for the Determination of Brexpiprazole in Different Matrices	13
Effect of Diosmin on Pharmacokinetics and Pharmacodynamics of Rivaroxaban in Rats	12
Explore the Constituents and Mechanism of Traditional Chinese Medicine Preparation Zhachong Shisan Pills Based on HPLC-QTOF-MS and Network Pharmacology	11
Metabolite Fingerprinting of Novel Streptomyces UK-238 from the Himalayan Forest	10
Integrated lipidomics and computational analyses reveal cardiolipin dysregulation as a therapeutic target in bortezomib-induced peripheral neuropathy	10
Head Space GC-MS/MS Method for Quantification of Five Nitrosoamine- Genotoxic Impurities in Metformin HCl	10
A Review of the Characteristics, Properties and Methods for Quantification of Roxithromycin	8
Comparison of ZIC-HILIC Columns for the Simultaneous Analysis of Antiviral Drugs in Dosage Forms by Hydrophilic Interaction Liquid Chromatography	7
Investigation of the Permeability of Antiretroviral Drugs Lamivudine and Valganciclovir via Single-Pass Intestinal Perfusion (SPIP) Method	7
Pitfalls and Opportunities in the Execution of Quality by Design in Analytical Sciences	7
An UHPLC-UV Method for the Determination of Vancomycin in Human Serum	7
Maraviroc Oral Disintegration Tablet: Analytical Design of Experiments (DoE) for Assessment and Comparison of In vitro Dissolution Profiles	6
A systematic and comprehensive review of the properties and synthesis of anticancer heterocyclic natural products	6
Integrated Quality by Design (QbD) Approach for Stability Indicating RPHPLC Method for the Estimation of Tadalafil Hydrochloride in Bulk Drug and Pharmaceutical Formulations	6
An Integrated Strategy for Rapid Screening of Multi-target Lead Compounds for the Treatment of Alzheimer's Disease from Traditional Chinese Medicines by UHPLC Combined with High-throughput Screening:	6
Simultaneous Determination of Six Bioactive Components of Astragali Radix in Rat Plasma Using Triple Quadrupole LC/MS and its Application to a Pharmacokinetic Study	6
Characterization of an Unknown Impurity in Indobufen Tablets by HPLC-Q-TOF MS and NMR	6
Evaluation and Application of ZIC-HILIC Columns Selectivity for Four Angiotensin II Receptor Blockers in Pharmaceutical Formulations	5
Mini-Review on Bioanalytical Estimation of Brinzolamide	5

Determination of Trans-loxoprofen-alcohol Tromethamine in Pregnant SD Rats by a Validated LC-MS/MS Method：Application to a Toxicokinetics and Tissue Distribution Study	5
Determination of pH-Solubility Profile and Development of Prediction Models for pH-Dependent Solubility of Atorvastatin Calcium	5
Analytical Methods for the Quantification of Cisplatin, Carboplatin, and Oxaliplatin in Various Matrices over the Last Two Decades	5
Determination of Acotiamide in Human Plasma by LC-MS/MS and its Application to a Pharmacokinetic Study	5
Charge Variants Analysis of a Bispecific Antibody Using a Fully Automated One-step Capillary Isoelectric Focusing - Mass Spectrometry Method	5
Stability Indicating Method for Known and Unknown Impurities Profiling for Vildagliptin in Vildagliptin Tablet	5
Ionic Liquids, Microextraction Methods and Capillary Electrophoresis in Biomedical Research	4
Analyzing Paraben Degradation in Parenteral Formulations with High-performance Liquid Chromatography	4
In silico exploration of Aloe vera leaf compounds as dual AChE and BChE inhibitors for Alzheimer’s disease therapy	4
Review on Analytical Methodologies, Chemical and Therapeutic Perspectives of Curcumin: A Ubiquitous Natural Molecule	4
Simultaneous Determination of D-amino Acids in Rat Urine by Highperformance Liquid Chromatography-tandem Mass Spectrometry Method: Application to Investigate the Clinical Value of D-amino Acids in the	4
Simultaneous Analysis of Sexual Stimulants and Anabolic Steroids as Adulterants in Dietary Supplements by High Performance Liquid Chromatography with Photodiode Array Detection	4
Development and Validation of a Simple HPLC-UV Method to Assay DEET Repellents and its Application to Different Commercial Forms	4
A Validated Method for Separation and Determination of Codeine Phosphate Hemihydrate Impurities in Bilayer Tablet Dosage Form of Naproxen Sodium and Codeine Phosphate by Using UHPLC	4
Bioinformatic methods uncover 5 diagnostic biomarkers associated with drug resistance and metastasis for gastrointestinal stromal tumor	4
Comprehensive Study on the Chemical Profile and Anti-Tumor Activity of Secondary Metabolites Produced by Aspergillus niger	4
Validation of RP-HPLC Method for Determination of Omeprazole in Dissolution Media and Application to Study in-vitro Release from Solid- SNEDDS	4
iTRAQ-based Proteomic Analysis Unveils NCAM1 as a Novel Regulator in Doxorubicin-induced Cardiotoxicity and DT-010-exerted Cardioprotection	4
Development and Validation of Teneligliptin Stereoisomers by HPLC Using Cellulose Based Immobilized Polysaccharide Chiral Stationary Phase	4
Molecular Absorption Scanning and Assay of Serotonin Reception Inhibitor Antidepressant Drugs	3
Determination of Thrombin Activity by Reversed-phase High Performance Liquid Chromatography	3
Bio-Analytical Method Development and Validation for Estimation of Zaltoprofen in Human Plasma by Reverse Phase -HPLC Method	3
Structure Analysis of Unsaturated Polymyxin E Components Based on High-Performance Liquid Chromatography - Quadrupole/ Time of Flight Tandem Mass Spectrometry and Photochemical Reaction	3
Simultaneous Detection of Phillyrin and its Three Metabolites in Rat Bile, Excrement and Urine via HPLC-ESI-MS/MS Quantitative Method	3
Detection of Diuretic Doping by Capillary Electrophoresis and Electrochemical Technology: A Mini-Review	3
Importance of Method Validation in the Analysis of Biomarker	3
Eco-friendly Spectrophotometric Methods for Assessment of Alfuzosin and Solifenacin in their new Pharmaceutical Formulation; Green Profile Evaluation via Eco-scale and GAPI Tools	3
Identification, Characterization, and the Determination of Process-related Impurities in Minodronic Acid Bulk Drug	3
Acknowledgements to Reviewers	3
Measurement Uncertainty and Validation for Quantification of Marijuana Metabolite: (−)-11-nor-9-Carboxy-Δ9-THC in Human Urine by GC-MS/MS	3
Chemometrics-assisted Spectrophotometric Method for Simultaneous Estimation of Antipsychotic Drugs in Biological Fluid	3
Elaboration and Validation of HPLC/DAD Method for Quality Control of Products Containing Cannabidiol	3
Voltammetric Determination of Diazepam on Antimony Film Screen- Printed Electrode in Pharmaceutical Formulations	3
A Diagnostic Tool for Good Chromatographic Practices Applied to HPLC in Pharmaceutical Quality Control	3
Identification of diagnostic biomarkers and therapeutic targets for abdominal aortic aneurysms based on disulfidptosis mechanism	3
Validation of GF-AAS Method for the Determination of Aluminium Content in Human Albumin Finished Product	3
Development and Validation of Stability-Indicating RP-HPLC Method for the Estimation of Fisetin in Novel Cubosomal Nanoformulation: Application to the Marketed Formulation and Selected Plant Extracts	3
A Quantitative LC-MS/MS Method for the Simultaneous Determination of the Presence of R-α-lipoic Acid and S-α-lipoic Acid After Protein Precipitation in Rat Plasma and its Application in a Toxicokineti	3
Metabolic Study of Benzamidenafil using Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry	3
Studies on the Anti-HBV Mechanism of Syringopicroside Based on Serum Metabolomics	3
Identification, Isolation and Characterization of a Pharmaceutical Impurity in Levocetirizine Hydrochloride	3
Protein Species of Origin Determination By NMR Relaxometry	3
Integrating Organ-on-chip Models In Drug Discovery: A Comprehensive Review on Innovations and Implications	3
Simultaneously Determining Seven Second-Line Anti-TB Drugs by UHPLC- MS: Application for TDM in HIV-TB Patients	3
Validation of the T-47D Cell Culture Bioassay for the Potency Assessment of Botulinum Neurotoxin Type A	3
Method Development and Validation for the Determination of Residual Solvents in Racecadotril by Gas Chromatography	3
Stability Study and Simultaneous Determination of Norepinephrine, Moxifloxacin, and Piperacillin + Tazobactam Mixtures Applied in Intensive Care Medicine	3
Application of Chemometrics-assisted HPLC-DAD Strategies for Simultaneous Determination of Paracetamol, Pseudoephedrine HCl, Dextromethorphan HBr, Doxylamine Succinate and Saccharin in Syrup Formulati	2
A Rapid and Selective UPLC-MS/MS Assay for Accurate Analysis of Apatinib in Rat Plasma and its Application to a Pharmacokinetic Study	2
Pharmacokinetics and Tissue Distribution Study of Daphnoretin in Ethanol Extract from the Roots of Wikstroemia Indica in Rats by a Validated UPLC-MS/MS Method	2

Formulation and evaluation of apigenin-loaded microsponge gel for effective angioedema therapy	2
Method Validation and Monitoring of N-nitrosodimethylamine in Metformin Hydrochloride Products in China by GC-MS/MS	2
Development and Validation of a Reliable LC-MS/MS Method for Simultaneous Quantification of Hydrochlorothiazide in the Presence of Different Co-formulated Anti-hypertensive Medications in Biological M	2
Methods for Analysis of Fluorinated Quinolones in Mixtures with Nitroimidazole Antibacterial Drugs	2
Development and Validation of a UPLC-MS/MS Method for the Simultaneous Determination of Verapamil and Trandolapril in Rat Plasma: Application to a Pharmacokinetic Study	2
A Review on Analytical Method Development for the Estimation of a Potent Muscarinic Receptor Antagonist Tolterodine Tartrate	2
Identification of Method-Induced Artifacts and Light Chain C-terminal Extension Sequence Variants in Therapeutic Monoclonal Antibodies by Complementary Analytical Methods	2
Study of Pharmaceutical Excipient PEG400 Alteration of Pharmacokinetics and Tissue Distribution of Main Flavonoids Metabolites of Baicalin	2
Efficient Green Solvent Extraction and Bioassay Studies of Favipiravir in Rat Dried Blood Spots Using Ionic Liquid-based Dispersive Liquid-liquid Microextraction (IL-DLLME) Coupled with HPLC-PDA: Appl	2
A Validated 2D-LC-UV Method for Simultaneous Determination of Imatinib and N-desmethylimatinib in Plasma and its Clinical Application for Therapeutic Drug Monitoring with GIST Patients	2
Research Progress on Quantification Methods of Drug Concentration of Monoclonal Antibodies	2
A Review on Different Analytical Techniques for Determination of DNP Drugs and their Metabolites in Pharmaceutical Formulations	2
Distribution, Metabolism, Excretion and Toxicokinetics of Vitexin in Rats and Dogs	2
Diagnosis Model of Hydrogen Sulfide Poisoning Based on Support Vector Machine	2
Metabolic Profiling Techniques and Their Application in Cancer Research	2
Green Analysis by Eco-scale Assessment for Quality Control of Azithromycin Tablets	2
Molecular Docking and Dynamic Simulation Approach to Target Penicillin- Binding Protein 1B (LpoB) of Salmonella typhimurium with Flavonoids	2
Improved Detection of Veterinary Drug Residues: Advancing Analytical Techniques to Ensure Food Safety	2
Analytical Method Development and Validation to Determine Oxidized Follitropin Recombinant Follicle Stimulating Hormone (rFSH) Injection by RP-HPLC	2
Advancing pharmaceutical research: A comprehensive review of cutting-edge tools and technologies	2
Validated RP-LC Methods for Investigating the Degradation Behavior of Acefylline: Application for Analysis in Two Binary Mixtures	2
Determination of three Unsaturated Fatty Acids in Pressure Ulcer Rats Using A UPLC-MS/MS Method	2
Development and Application of Chitosan Nanogel as a Sorbent for Methotrexate Extraction	2
Development of Acid-Neutralization and In Vitro Dissolution to Evaluate the Overall Quality of Compound Aluminum Hydroxide Tablets	2
Universally Applicable Methods for Comprehensive Risk Assessment of Elemental Impurities in Vitamin A and D Preparations	2
Isolation and Characterization of An Allergic Dimer Impurity in Cefmenoxime Hydrochloride by NMR and HR-MS Method	2
Determination of Two Potential Genotoxic Impurities in Crisaborole API by UPLC-MS/MS	2
Development of Simple HPLC-UV Method for the Simultaneous Determination of Repaglinide, Dexamethasone, and Remdesivir, and its Application to Synthetic Mixture and Human Plasma	2
Development and Validation of an Eco-Friendly Liquid Chromatography- Tandem Mass Spectrometry Method for Rapid Quantification of Γ-Aminobutyric Acid in Cordyceps sinensis and its Related Species	2
A Review: Drug Excipient Iincompatiblity by Ftir Spectroscopy	2
Establishment and Validation of a Robust Reversed-Phase HPLC Method for the Determination of Calotropis gigantea in Bulk Material and Marketed Product	2