OOIR: Observatory of International Research

Papers

(The TQCC of Current Pharmaceutical Analysis is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Analysis of Shenhuang Capsule using HPLC: Method Development, Validation, and Application	92
Application of a Quantitative Proton Nuclear Magnetic Resonance Method for the Determination of Protopine in Radix Dactylicapnotis	82
Characteristics, Biological Activities, Synthesis, and Methods for the Determination of Brexpiprazole in Different Matrices	77
Effect of Diosmin on Pharmacokinetics and Pharmacodynamics of Rivaroxaban in Rats	67
Explore the Constituents and Mechanism of Traditional Chinese Medicine Preparation Zhachong Shisan Pills Based on HPLC-QTOF-MS and Network Pharmacology	38
Non-enzymatic Glucose Detection by Fe₂O₃ Nanorods-reduced Graphene under Physiological pH	36
Head Space GC-MS/MS Method for Quantification of Five Nitrosoamine- Genotoxic Impurities in Metformin HCl	28
Integrated lipidomics and computational analyses reveal cardiolipin dysregulation as a therapeutic target in bortezomib-induced peripheral neuropathy	24
An Integrated Strategy for Rapid Screening of Multi-target Lead Compounds for the Treatment of Alzheimer's Disease from Traditional Chinese Medicines by UHPLC Combined with High-throughput Screening:	20
Comparison of ZIC-HILIC Columns for the Simultaneous Analysis of Antiviral Drugs in Dosage Forms by Hydrophilic Interaction Liquid Chromatography	19
Investigation of the Permeability of Antiretroviral Drugs Lamivudine and Valganciclovir via Single-Pass Intestinal Perfusion (SPIP) Method	16
A systematic and comprehensive review of the properties and synthesis of anticancer heterocyclic natural products	15
Simultaneous Determination of Six Bioactive Components of Astragali Radix in Rat Plasma Using Triple Quadrupole LC/MS and its Application to a Pharmacokinetic Study	14
Maraviroc Oral Disintegration Tablet: Analytical Design of Experiments (DoE) for Assessment and Comparison of In vitro Dissolution Profiles	14
Pitfalls and Opportunities in the Execution of Quality by Design in Analytical Sciences	11
An automated sample pretreatment system for liquid–liquid extraction and its application in the analysis of four steroid hormones in human plasma	10
Charge Variants Analysis of a Bispecific Antibody Using a Fully Automated One-step Capillary Isoelectric Focusing - Mass Spectrometry Method	10
Determination of pH-Solubility Profile and Development of Prediction Models for pH-Dependent Solubility of Atorvastatin Calcium	10
Determination of Trans-loxoprofen-alcohol Tromethamine in Pregnant SD Rats by a Validated LC-MS/MS Method：Application to a Toxicokinetics and Tissue Distribution Study	9
Mini-Review on Bioanalytical Estimation of Brinzolamide	8
Bioinformatic methods uncover 5 diagnostic biomarkers associated with drug resistance and metastasis for gastrointestinal stromal tumor	7
Identification of potential anti-tubercular inhibitors through virtual screening, DFT, and molecular dynamics simulation studies	6
Evaluation and Application of ZIC-HILIC Columns Selectivity for Four Angiotensin II Receptor Blockers in Pharmaceutical Formulations	6
Comprehensive Study on the Chemical Profile and Anti-Tumor Activity of Secondary Metabolites Produced by Aspergillus niger	6
Identification of key molecular targets and mechanism of action in acute kidney injury by integrating network pharmacology and molecular docking	6

Single-cell RNA sequencing identifies CCR4 as a therapeutic target for sepsis with DB07845 as a potential inhibitor	6
Analyzing Paraben Degradation in Parenteral Formulations with High-performance Liquid Chromatography	6
Analytical Methods for the Quantification of Cisplatin, Carboplatin, and Oxaliplatin in Various Matrices over the Last Two Decades	6
Ionic Liquids, Microextraction Methods and Capillary Electrophoresis in Biomedical Research	5
iTRAQ-based Proteomic Analysis Unveils NCAM1 as a Novel Regulator in Doxorubicin-induced Cardiotoxicity and DT-010-exerted Cardioprotection	5
Metabolic Study of Benzamidenafil using Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry	5
Measurement Uncertainty and Validation for Quantification of Marijuana Metabolite: (−)-11-nor-9-Carboxy-Δ9-THC in Human Urine by GC-MS/MS	5
Impact of sodium carbonate processing on the chemical profile and antimicrobial properties of saussurea lappa root extracts	5
Review on Analytical Methodologies, Chemical and Therapeutic Perspectives of Curcumin: A Ubiquitous Natural Molecule	5
Validation of RP-HPLC Method for Determination of Omeprazole in Dissolution Media and Application to Study in-vitro Release from Solid- SNEDDS	5
Acknowledgements to Reviewers	5
Exploring antiproliferative potential, in silico docking, and molecular dynamics of pyrimidine-morpholine hybrid molecules	5
In silico exploration of Aloe vera leaf compounds as dual AChE and BChE inhibitors for Alzheimer’s disease therapy	5
Determination of Thrombin Activity by Reversed-phase High Performance Liquid Chromatography	5
Molecular Absorption Scanning and Assay of Serotonin Reception Inhibitor Antidepressant Drugs	5
Studies on the Anti-HBV Mechanism of Syringopicroside Based on Serum Metabolomics	4
Development and Validation of Stability-Indicating RP-HPLC Method for the Estimation of Fisetin in Novel Cubosomal Nanoformulation: Application to the Marketed Formulation and Selected Plant Extracts	4
Identification of diagnostic biomarkers and therapeutic targets for abdominal aortic aneurysms based on disulfidptosis mechanism	4
Simultaneous Detection of Phillyrin and its Three Metabolites in Rat Bile, Excrement and Urine via HPLC-ESI-MS/MS Quantitative Method	4
Validation of the T-47D Cell Culture Bioassay for the Potency Assessment of Botulinum Neurotoxin Type A	4
A Quantitative LC-MS/MS Method for the Simultaneous Determination of the Presence of R-α-lipoic Acid and S-α-lipoic Acid After Protein Precipitation in Rat Plasma and its Application in a Toxicokineti	4
Protein Species of Origin Determination By NMR Relaxometry	4
Stability Study and Simultaneous Determination of Norepinephrine, Moxifloxacin, and Piperacillin + Tazobactam Mixtures Applied in Intensive Care Medicine	4
Identification, Characterization, and the Determination of Process-related Impurities in Minodronic Acid Bulk Drug	4
Importance of Method Validation in the Analysis of Biomarker	4
Structure Analysis of Unsaturated Polymyxin E Components Based on High-Performance Liquid Chromatography - Quadrupole/ Time of Flight Tandem Mass Spectrometry and Photochemical Reaction	4
Integrating Organ-on-chip Models In Drug Discovery: A Comprehensive Review on Innovations and Implications	4
Detection of Diuretic Doping by Capillary Electrophoresis and Electrochemical Technology: A Mini-Review	4
Implementation of QbD approach in RP-HPLC method optimization and validation for concurrent estimation of Deflazacort and Tamsulosin hydrochloride under ICH Q14 and Q2R2 framework	4
Simultaneously Determining Seven Second-Line Anti-TB Drugs by UHPLC- MS: Application for TDM in HIV-TB Patients	4
Validation of GF-AAS Method for the Determination of Aluminium Content in Human Albumin Finished Product	4
Development and Validation of an Eco-Friendly Liquid Chromatography- Tandem Mass Spectrometry Method for Rapid Quantification of Γ-Aminobutyric Acid in Cordyceps sinensis and its Related Species	3
A Diagnostic Tool for Good Chromatographic Practices Applied to HPLC in Pharmaceutical Quality Control	3
Determination of Two Potential Genotoxic Impurities in Crisaborole API by UPLC-MS/MS	3
Metabolic Profiling Techniques and Their Application in Cancer Research	3
Molecular Docking and Dynamic Simulation Approach to Target Penicillin- Binding Protein 1B (LpoB) of Salmonella typhimurium with Flavonoids	3
Trifluridine/tipiracil exhibits potent antitumor activity in triple-negative breast cancer by targeting SKP2 and inducing cell cycle arrest and apoptosis	3
Analytical Method Development and Validation to Determine Oxidized Follitropin Recombinant Follicle Stimulating Hormone (rFSH) Injection by RP-HPLC	3
Network pharmacology, molecular docking, and molecular dynamics simulation in drug development: A comprehensive perspective	3
Identification of Method-Induced Artifacts and Light Chain C-terminal Extension Sequence Variants in Therapeutic Monoclonal Antibodies by Complementary Analytical Methods	3
Distribution, Metabolism, Excretion and Toxicokinetics of Vitexin in Rats and Dogs	3
Development and Validation of a UPLC-MS/MS Method for the Simultaneous Determination of Verapamil and Trandolapril in Rat Plasma: Application to a Pharmacokinetic Study	3
Universally Applicable Methods for Comprehensive Risk Assessment of Elemental Impurities in Vitamin A and D Preparations	3
Development and Application of Chitosan Nanogel as a Sorbent for Methotrexate Extraction	3
Exploring the Potential Anti-Hepatocarcinoma Mechanism of Ruangan Lidan Decoction through UHPLC-Q-TOF-MS/MS Analysis and Network Pharmacology Approaches	3
Advancing pharmaceutical research: A comprehensive review of cutting-edge tools and technologies	3
Efficient Green Solvent Extraction and Bioassay Studies of Favipiravir in Rat Dried Blood Spots Using Ionic Liquid-based Dispersive Liquid-liquid Microextraction (IL-DLLME) Coupled with HPLC-PDA: Appl	3
Establishment and Validation of a Robust Reversed-Phase HPLC Method for the Determination of Calotropis gigantea in Bulk Material and Marketed Product	3
A Validated 2D-LC-UV Method for Simultaneous Determination of Imatinib and N-desmethylimatinib in Plasma and its Clinical Application for Therapeutic Drug Monitoring with GIST Patients	3
Formulation and evaluation of apigenin-loaded microsponge gel for effective angioedema therapy	3

Chemical characterization, antioxidant effect and xanthine oxidase inhibition of Micromeria fruticosa (L.) druce hexane extract	3
Research Progress on Quantification Methods of Drug Concentration of Monoclonal Antibodies	3
Pharmacokinetics and Tissue Distribution Study of Daphnoretin in Ethanol Extract from the Roots of Wikstroemia Indica in Rats by a Validated UPLC-MS/MS Method	3
A Review on Analytical Method Development for the Estimation of a Potent Muscarinic Receptor Antagonist Tolterodine Tartrate	3
Unveiling cloperastine fendizoate degradation using MS/MS: A novel HPLC method for simultaneous analysis with parabens and degradant characterization	3
Development of Acid-Neutralization and In Vitro Dissolution to Evaluate the Overall Quality of Compound Aluminum Hydroxide Tablets	3