Current Pharmaceutical Analysis

Article	Citations
Molecularly Imprinted Electrochemical Sensors: Analytical and Pharmaceutical Applications Based on Ortho-Phenylenediamine Polymerization	23
Eco-friendly Spectrophotometric Methods for Assessment of Alfuzosin and Solifenacin in their new Pharmaceutical Formulation; Green Profile Evaluation via Eco-scale and GAPI Tools	19
Voltammetric Pathways for the Analysis of Ophthalmic Drugs	17
Albumin-based Nanoparticles as Promising Drug Delivery Systems for Cancer Treatment	14
Hydrophilic Interaction Liquid Chromatography (HILIC): Latest Applications in the Pharmaceutical Researches	13
Validation of Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry Coupled with Electrospray Ionization Method for Quantitative Determination of Ornidazole in Solid Dispersion	10
A Review of the Occurrence of Pharmaceutical Compounds as Emerging Contaminants in Treated Wastewater and Aquatic Environments	9
Recent Developments in the Electrochemical Determination of Sulfonamides	9
Chemically Modified Electrodes in Electrochemical Drug Analysis	8
Determination of Pharmaceuticals by UV-Visible Spectrophotometry	8
Development of 96-microwell Plate Assay with Fluorescence Reader and HPLC Method with Fluorescence Detection for High-throughput Analysis of Linifanib in its Bulk and Dosage Forms	7
Pharmacokinetics of Picroside I, II, III, IV in Rat Plasma by UPLCMS/ MS	7
Applications of QbD-based Software’s in Analytical Research and Development	7
Smart Multivariate Spectrophotometric Assisted Techniques for Simultaneous Determination of Ephedrine Hydrochloride and Naphazoline Nitrate in the Presence of Interfering Parabens	7
Survey on Multi-omics, and Multi-omics Data Analysis, Integration and Application	5
Hydrophilic Interaction Chromatography Analysis of Esculin in Ointments with UV Detection	5
Past, Present and Future of Electroanalytical Sensor for Aspirin, Ibuprofen and Paracetamol Detection	5
Analytical Methods Practiced to Quantitation of Rifampicin: A Captious Survey	5
Development and Validation of HPLC Method for Five Gliptins in Pharmaceutical Dosage Forms in Finished Marketed Products	5
Fingerprint Analysis of Vitex Negundo by HPLC Coupled with Multi-components Analysis	5
Study of the Fragmentation Pathways of Sulfonamides by High-resolution Mass Spectrometry: Application to their Detection in Plasma by Direct Infusion	5
Pharmacokinetic Study of Zhebeirine in Mouse Blood by Ultra- Performance Liquid Chromatography/tandem Mass Spectrometry	5
Elemental Impurities Determination by ICP-AES / ICP-MS: A review of Theory, Interpretation of Concentration Limits, Analytical Method Development Challenges and Validation Criterion for Pharmaceutical	5
Metallic Impurities in Pharmaceuticals: An Overview	5
A Comparative Pharmacokinetic Study of Schisandrol B After Oral Administration of Schisandrol B Monomer and Schisandra chinensis Extract	5

Development and Validation of an LC-MS/MS Method for Simultaneous Determination of Canagliflozin and Metformin HCl in Rat Plasma and its Application	5
Detection of Diuretic Doping by Capillary Electrophoresis and Electrochemical Technology: A Mini-Review	4
Voltammetric Determination of Guaifenesin in Pharmaceuticals and Urine Samples Based on Poly(Bromocresol Purple) Modified Glassy Carbon Electrode	4
Ultrasound Assisted Dispersive Solid Phase Microextraction of Thymol and Carvacrol in Pharmaceutical Products Using Graphene Oxide as an Adsorbent Prior to Analysis by High Performance Liquid Chromato	4
RP-HPLC In-Vitro Dissolution Method Development and Validation for Determination of Olmesartan Medoxomil, Chlorthalidone and Cilnidipine Drug Combinations	4
UPLC-MS/MS Determination of Chlorogenic Acid, Hyperoside and Astragalin in Plasma and its Pharmacokinetic Application in Liver Injury Rats	4
Chemometrics-assisted Spectrophotometric Method for Simultaneous Estimation of Antipsychotic Drugs in Biological Fluid	4
Elaboration and Validation of HPLC/DAD Method for Quality Control of Products Containing Cannabidiol	4
Impact of UPLC-MS in Food and Drug/Metabolite Analysis	4
Simultaneous Determination of Alogliptin and Pioglitazone in Human Plasma by a Novel LC-MS/MS Method	4
A Review on Analytical Methods of Irbesartan and its Combinations in Pharmaceutical Dosage Forms	4
UPLC-MS/MS Method for Determination of Khasianine in Mouse Blood: Application for Its Pharmacokinetic Study	4
Determination of Main Compositions in Phyllanthus Urinaria and its Effects on Cyp450 in Rats	4
New Coronavirus Outbreak	4
Determination of Shanzhiside Methylester in Rat Plasma by Uplc-Ms/Ms and its Application to a Pharmacokinetic Study	4
Determination of Impurities in Perampanel Bulk Drugs by High- Performance Liquid Chromatography and Gas Chromatography	3
A Suitable Immunosensor for Chloramphenicol Determination: Study of Two Different Competitive Formats	3
An LC-MS/MS Method for Determination of Triple Drugs Combination of Valsartan, Amlodipine and Hydrochlorothiazide in Human Plasma for Bioequivalence Study	3
Analytical Techniques in the Analysis of Darunavir and Ritonavir: A Review	3
Recent Electrochemical Assays on Cephalosporins	3
Progress in the Electrochemical Analysis of Flavonoids: A Scientometric Analysis in CiteSpace	3
Validation of RP-HPLC Method for Determination of Omeprazole in Dissolution Media and Application to Study in-vitro Release from Solid- SNEDDS	3
A Gas Chromatography Flame Ionization Detector Method for Rapid Simultaneous Separation and Determination of Six Active Ingredients of Anticold Drug	3
Development, Validation, and Application of a High-Performance Liquid Chromatography Method for the Analysis of Dissolution Samples of Telmisartan and Rosuvastatin Calcium Double-Layer Formulation	3
An Overview of Excipients Classification and Their Use in Pharmaceuticals	3
A Sensitive Chromatographic Method for Hyaluronate Quantification Applied to Analyze the Desorption Behavior on Contact Lenses	3
Validated RP-LC Methods for Investigating the Degradation Behavior of Acefylline: Application for Analysis in Two Binary Mixtures	3
Recent Trends in Chiral Separation-A Collective Paradigm of Selected Chiral Impurities	3
Study and Determination of Aluminum in Dextran 40 Glucose Injection by ICP-MS	3
A Label-free Electrochemical Immunosensor for Highly Sensitive Detection of TNF α, Based on Star Polymer-modified disposable ITO Electrode	3
A Versatile Stability-indicating Liquid Chromatographic Method for the Simultaneous Determination of Atenolol, Hydrochlorothiazide and Chlorthalidone	3
Novel Rapid Isocratic RP-HPLC Method for Simultaneous Estimation of Phenylephrine Hydrochloride, Paracetamol, Caffeine, Diphenhydramine Hydrochloride	3
Ionic Liquids, Microextraction Methods and Capillary Electrophoresis in Biomedical Research	3
Study of Pharmaceutical Excipient PEG400 Alteration of Pharmacokinetics and Tissue Distribution of Main Flavonoids Metabolites of Baicalin	3
Analysis of Nonsteroidal Anti-inflammatory Drugs by using Microfluidic Techniques: A Review	3
Potential Impurities of Tigecycline: Synthesis, Isolation, Characterization and In Vitro Pharmacological Evaluation	3
Exploiting Kinetic Solubility Differences for Low Level Detection of Crystallinity in Amorphous Drug Formulations	3
Electrochemical Determination of Norepinephrine at Poly (p-aminobenzenesulfonic Acid) Modified Sensor	3
An Easy Efficient Method of Veterinary Drug Residue Analysis in Raw Milk by RP-HPLC-UV with Application to Raw Milk	3
Direct Injection Microemulsion HPLC Method for Simultaneous Determination of Morphine, Tramadol and Lornoxicam in Biological Fluids Using Monolithic Column	3
Strategies for the Separation and Quantification of Non-Steroidal Anti- Inflammatory Drugs Using ZIC-HILIC-HPLC with UV Detection	3
Determination of Endocrine Disruptor Bisphenol-A Leakage from Different Matrices of Dental Resin-based Composite Materials	3
Nano-sized Metal and Metal Oxide Modified Electrodes for Pharmaceuticals Analysis	3
Comparison of HPLC-DAD and UPLC-MS/MS in Monitoring Serum Concentration of Lamotrigine	3
Simultaneous Determination of Alogliptin, Linagliptin, Saxagliptin, and Sitagliptin in Bulk Drug and Formulation by UPLC Q-TOF-MS	3
Preface	3
Chiral Separation of Oxomemazine Enantiomers by HPLC Technique and Enantiomeric Separation Mechanism via Docking Studies	3
Analytical Methods for the Quantification of Cisplatin, Carboplatin, and Oxaliplatin in Various Matrices over the Last Two Decades	2
Characterization of an Unknown Impurity in Indobufen Tablets by HPLC-Q-TOF MS and NMR	2
Development of Validated Stability Indicating HPTLC Method for the Estimation of Teriflunomide in Bulk and Tablet Dosage Form	2

An UPLC-MS/MS Method for Routine Quantification of Insulin Degludec in Plasma	2
A New Stability-indicating Chiral RP-HPLC Method for the Determination of Degradation Products in Meclizine Hydrochloride	2
Determination of Loratadine and Its Active Metabolite in Plasma by LC/MS/MS: An Adapted Method for Children	2
Simultaneous Analysis of Ipratropium Bromide and its Related Substances Using HPLC	2
Importance of Method Validation in the Analysis of Biomarker	2
Novel Simultaneous Identification of Capsaicin and It’s Quantification in Transferosome Formulation By HP-TLC Technique	2
Spectrophotometric Determination of Vitamin B1 in Dosage forms Using Drugs Compounds as Reagents by Normal and Reverse Flow Injection Methods	2
Quantitative Determination and Validation of Four Phenolic Acids in Salvia Miltiorrhiza Bunge using 1H-NMR Spectroscopy	2
Development and Validation of a Novel Reversed Phase High Performance Liquid Chromatography with Refractive Index Detector Method for Assay of Polyvinyl Alcohol in an Ophthalmic Solution	2
Determination of Free Amino Acids in Banlangen Granule and its Fractions by Solid Phase Extraction Combined with Ion-pair Hig-h Perfor mance Liquid Chromatography using a Corona-charged Aerosol Detect	2
Pharmacokinetic Differences of Grape Seed Procyanidins According to the Gavage Administration Between Normal Rats and Alzheimer's Disease Rats	2
Rapid Determination of Acarbose in Tablets by 1H NMR Spectroscopy	2
HPLC Tests in Quality Control under the Market Surveillance Program for Medicinal Products Containing Amlodipine and Valsartan	2
Simultaneous Determination of D-amino Acids in Rat Urine by Highperformance Liquid Chromatography-tandem Mass Spectrometry Method: Application to Investigate the Clinical Value of D-amino Acids in the	2
Assessment of Purity Parameters of Generic and Brand Name Losartan Potassium	2
Determination of Meloxicam Using Direct and Indirect Flow Injection Spectrophotometry	2
Characteristics, Biological Activities, Synthesis, and Methods for the Determination of Brexpiprazole in Different Matrices	2
Difference of Chemical Compositions in Fu Zheng Fang with Different Dosage Forms Based on HPLC-Q-Exactive Orbitrap/MS Combined with Multivariate Statistical Analysis	2
Systemic Optimization and Validation of RP-HPLC Method for the Estimation of Ritonavir from Hybrid Polymeric Nanoparticles in Rat Plasma	2
Development and Validation of a Method for Simultaneous Estimation of Sitagliptin and Ertugliflozin in Rat Plasma by LC-MS method	2
Pharmacokinetics of Benzoic Acid, 4-[[(2-Hydroxyethyl)Amino]Carbonyl]- Methyl Ester from Portulaca Oleracea L. in Rats after Intravenous and Oral Administrations Using UHPLC-ESI-Q-TOF/MS	2
Permeation of Hydroxypropyl-Beta-Cyclodextrin and Its Inclusion Complex Through Mouse Small Intestine Determined by Spectrophotometry	2
Quantitation of Pregabalin by HPLC-UV Method using Ninhydrin Derivatization: Development and Validation	2
Characterization of 10 Biogenic Amines in Male Silkworm Moth by HPLC with Precolumn Derivatization	2
Development and Validation of an HPLC Method for the Quantification of Morin Flavonoid Encapsulated within PLGA Nanoparticles	2
Development of a Quantitative NMR Method for Direct and Simultaneous Determination of Four Flavonoids in Scutellaria baicalensis georgi Extracts	2
Risk Assessment, Screening and Control of Elemental Impurities in Pharmaceutical Drug Products: A Review	2
Comparative Study of Different Derivative Spectrophotometric Techniques for the Analysis and Separation of Metformin, Empagliflozin, and Glimepiride	2
Stereospecific Determination of Sertraline and its Impurities in Bulk Drug Using Cyclodextrins as a Chiral Selector	2
Far Infrared-assisted Sample Extraction and Solvent Removal for Capillary Electrophoretic Determination of the Bioactive Constituents in Citri Reticulatae Pericarpium	2
Charge Variants Analysis of a Bispecific Antibody Using a Fully Automated One-step Capillary Isoelectric Focusing - Mass Spectrometry Method	2
Analytical Aspects for Evaluation of Pharmaceutical Products: A Mini- Review	2
Therapeutic Monitoring of Plasma Digoxin for COVID-19 Patients Using a Simple UPLC-MS/MS Method	2
Method Development and Validation for the Determination of Linezolid Drug in Human Plasma by Reversed-Phase High-Performance Liquid Chromatography	2
Advances in the Use of Graphene Nanocomposites for the Electrochemical Determination of Glucose: A Review	2
Trace Determination of Tamoxifen using Optimized Solvent Bar Microextraction and HPLC-UV	2
Chemical Fingerprint Analysis and Simultaneous Determination of Nucleosides and Amino Acids in Kang Fu Xin Liquid by High Performance Liquid Chromatography with Diode Array Detector	2
Investigation on the Metabolism of Curcumin and Baicalein in Zebrafish by Liquid Chromatography-tandem Mass Spectrometry Analysis	2
An UHPLC-UV Method for the Determination of Vancomycin in Human Serum	2
A Reliable HPLC-ELSD Method for Determination of Cholesterol, Phosphatidylcholine, Lysophosphatidylcholine Content and the Stability of a Liposomal Formulation	2
A Validated Method for Separation and Determination of Codeine Phosphate Hemihydrate Impurities in Bilayer Tablet Dosage Form of Naproxen Sodium and Codeine Phosphate by Using UHPLC	1
Comprehensive Analysis of Purity and Glycosylation Status of Chinese Marketed Recombinant and Urinary FSHs	1
Selective and Sensitive UHPLC Method for the Trace Analysis of Formaldehyde in Drug Substance Using Fused-core Column Technology and Detailed Pre-column Derivatization study	1
Development and Validation of a UPLC-MS/MS Method for the Simultaneous Determination of Verapamil and Trandolapril in Rat Plasma: Application to a Pharmacokinetic Study	1
Units and Methods of Proteolytic Activity Determination	1
QbD Approach For Anti-Cancer Drugs - A Review	1
An RP-HPLC Method for Quantitative Analysis of Linagliptin Entrapped in Nanotransfersomes and its Application to Skin Permeation Studies	1
Method Development and Validation for the Determination of Residual Solvents in Racecadotril by Gas Chromatography	1
Review on Analytical Methodologies, Chemical and Therapeutic Perspectives of Curcumin: A Ubiquitous Natural Molecule	1
A Comparative Chemometric Study for Quantitative Determination of Duloxetine Hydrochloride in the Presence of its Toxic Impurity 1-Naphthol	1
Content and Composition of Phospholipids, Fatty Acids and Sterols in Commercial Natural Phospholipid Excipients	1
A Highly Sensitive LC–MS/MS Method Development and Validation of Fedratinib in Human Plasma and Pharmacokinetic Evaluation in Healthy Rabbits	1
An Overview: The Evaluation of Formation Mechanisms, Preparation Techniques and Chemical and Analytical Characterization Methods of the In Situ Forming Implants	1
Evaluation and Application of ZIC-HILIC Columns Selectivity for Four Angiotensin II Receptor Blockers in Pharmaceutical Formulations	1
LC-MS/MS Analytical Method for Determination of Montelukast in Human Plasma and its Application to a Bioequivalence Study	1
Analytical Methodologies for Determination of Hydroxychloroquine and its Metabolites in Pharmaceutical, Biological and Environmental Samples	1
Determination of Pyridostigmine Bromide in Presence of its Related Impurities by Four Modified Classical Least Square Based Models: A Comparative Study	1
Comparison Study on the Contents of Eight Flavonoids in three Different Processed Products of Scutellariae Radix using Ultra-high Performance Liquid Chromatography Coupled With Triple-Quadrupole Mass	1
Crystal Transition and Drug-excipient Compatibility of Clarithromycin in Sustained Release Tablets	1
Development of Fast and Simple LC-ESI-MS/MS Technique for the Quantification of Regorafenib; Application to Pharmacokinetics in Healthy Rabbits	1
A Sensitive HPLC-MS/MS Method for the Quantification of Selegiline in Beagle Dog Plasma: Application to a Pharmacokinetic Study	1
Sensitive Detection of Levocetirizine as a new Generation Antihistamine by Stripping Square Wave Voltammetry	1
Calcium/Copper Alginate Framework Doped with CuO Nanoparticles as a Novel Adsorbent for Micro-extraction of Benzodiazepines from Human Serum	1
Quantitative Analysis of 5-Hydroxymethylfurfural in Linezolid Injection by High Performance Liquid Chromatography	1
Ultrafiltration-based Sample Preparation for Pharmaceutical Analysis	1
A Critical Review on Smartphone Based Determinations of Drugs	1
Challenges, Progress and Promises of Impurities Annotation for LCMSIT- TOF	1
Review on Determination of Berberine in Biological and Pharmaceutical Matrices: An Analytical and Therapeutic Perspective	1
The Metabolism of Tanshinone IIA, Protocatechuic Aldehyde, Danshensu, Salvianolic Acid B and Hydroxysafflor Yellow A in Zebrafish	1
Development and Validation of A High-Performance Liquid Chromatography- Mass Spectroscopy Assay for the Bioequivalence Study of Guanfacine Extended Release (GXR) Tablet in Human Plasma	1
Simultaneous Analysis of Sexual Stimulants and Anabolic Steroids as Adulterants in Dietary Supplements by High Performance Liquid Chromatography with Photodiode Array Detection	1
Simultaneous Determination of Eight Potential Q-Markers in Zishen Tongguan Capsules Based on UHPLC-MS/MS	1
Identification, Characterization, and the Determination of Process-related Impurities in Minodronic Acid Bulk Drug	1
Q-TOF LC/MS-based Untargeted Metabolomics Approach to Evaluate the Effect of Folate-Conjugated Cyclodextrins on Triple-Negative Breast Cancer Cells	1
A Validated LC-MS/MS Method for the Determination of Mezlocillin in Plasma: An Adapted Method for Therapeutic Drug Monitoring in Children	1
Analytical Methods for the Identification of Pigments in Tattoo Inks and Some of Their Physiological Side Effects: A Review	1
Recent Applications of High Performance Thin Layer Chromatography and Derivative Spectrophotometry in Pharmaceutical Analysis	1
Voltammetric Determination of Diazepam on Antimony Film Screen- Printed Electrode in Pharmaceutical Formulations	1
Analytical Techniques for the Estimation of Perindopril Erbumine: A Review	1
Progress in Quantitative Methods for Azelnidipine and Chlorthalidone: An Analytical Basis for a Recently Approved FDC	1

Voltammetric Methods Used in the Determination of Nucleoside Reverse Transcriptase Inhibitors	1
Advances in Electrochemical Methods for the Analysis of Pharmaceuticals	1
A Review on Different Analytical Techniques for Determination of DNP Drugs and their Metabolites in Pharmaceutical Formulations	1
Characterization of Allergic Polymerized Impurities in Cephalosporins by MALDI-TOF MS/MS Spectrometry	1
Development and Validation of Teneligliptin Stereoisomers by HPLC Using Cellulose Based Immobilized Polysaccharide Chiral Stationary Phase	1
Progress in Analytical Techniques for Remogliflozin Etabonate, Vildagliptin And Metformin Hydrochloride: A Recently, Approved FDC	1
Mini-Review on Bioanalytical Estimation of Brinzolamide	1
Simultaneous and Sensitive Determination of Amphetamine, Codeine and Morphine in Exhaled Breath Condensate, Using Capillary Electrophoresis Coupled with On-line and Off-line Enhancing Methods	1
Development and Validation of a Microbiological Agar Assay for Determination of Thiamphenicol in Soft Capsules	1
Methods for Analysis of Fluorinated Quinolones in Mixtures with Nitroimidazole Antibacterial Drugs	1
Azithromycin Nanosuspension Preparation using Evaporative Precipitation into the Aqueous Solution (EPAS) Method and its Comparative Dissolution Study	1
LC-MS/MS Method Development and Validation of Lenvatinib and its Related Impurities in Rat Plasma: Application to a Pharmacokinetic Study	1
Integrated Quality by Design (QbD) Approach for Stability Indicating RPHPLC Method for the Estimation of Tadalafil Hydrochloride in Bulk Drug and Pharmaceutical Formulations	1
Comprehensive Study on the Chemical Profile and Anti-Tumor Activity of Secondary Metabolites Produced by Aspergillus niger	1
Spectroscopic Determination of Dissociation Constants of Some 4- nitrobenzaldehyde-4-substituted phenyl-1-carbonylhydrazones in Sodium Hydroxide Media	1
Quantification and Pharmacokinetics Study of Pedunculoside in Rats by Using UPLC-MS/MS	1
The Metabolism of Portulacatone B from Portulaca oleracea L. in Rats by UHPLC-ESI-Q-TOF/MS	1
Volatile Chemical Profile of Ethanol-based Hand Sanitizer Marketed in Brazil by HS-SPME/GC-MS	1
Metabolite Detection and Profiling Using Analytical Methods	1
Ultra-Performance Liquid Chromatography Coupled with a Triple Quadrupole Mass Spectrometric Method for the Quantification of Antiepileptic Drugs Methsuximide and Normesuximide in Human Plasma and its	1
LC-MS/MS Method Development and Validation for the Determination of Ilexsaponin A1 and Its Application in Intestinal Bacterial Metabolic Study	1
Development of HPLC Method for the Purity Test by Design of Experiments and Determination of Activation Energy of Hydrolytic Degradation Reactions of Sofosbuvir	1
Metabolic Changes in Rat Plasma After Epilepsy by UPLC-MS/MS	1
Trace Extraction of Metoprolol from Plasma, Urine and EBC Samples Using Modified Magnetic Nanoparticles Followed by Spectrofluorimetric Determination for Drug Monitoring Purposes	1
Metabolic Changes in Mouse Plasma after Acute Diquat Poisoning by UPLC-MS/MS	1
Metabolic Changes in Hyperlipidemic Rats After The Administration of Xuezhikang	1
Analysis of the Genotoxic Impurity S-(+)-Epichlorohydrin Contained in (S)-Oxiracetam using Gas Chromatography	1
Will MXenes be the Next Two-dimensional Material Candidate for Biosensing?	1
Establishment of HLB-UPLC-MS/MS Method to Determine Hainanmycin Sodium in Chicken Liver	1
An Overview of Analytical Methods for the Identification and Quantification of Baclofen	1
Pharmacokinetics of Recombinant Human Growth Hormone (rhGH) in Beagles by ELISA	1
Establishing Tablet Dissolution Curve Through Determination of Underivatized Alendronate Sodium by Capillary Electrophoresis-UV Detector	1
Acknowledgements to Reviewers	1
Development and Validation of a Rapid and Efficient Method for Simultaneous Determination of Scopolin and Scopoletin in Convolvulus Species by Ultra- high-performance Liquid Chromatography-Tandem Mass	1
Sequential Injection Chromatography with Monolithic Column for Phenothiazines Assay in Human Urine and Pharmaceutical Formulations	1
Development and Validation of RP-HPLC Method for the Simultaneous Determination of Levamisole HCl and Oxyclozanide and its Application in the Assay of Veterinary Bolus Formulations	1
Establishment and Validation of an ICP-MS Method for Simultaneous Measurement of 24 Elemental Impurities in Ubenimex APIs According to USP/ICH guidelines	1
A Rapid and Selective UPLC-MS/MS Assay for Accurate Analysis of Apatinib in Rat Plasma and its Application to a Pharmacokinetic Study	1
Acknowledgements to Reviewers	1
Application of Chemometrics-assisted HPLC-DAD Strategies for Simultaneous Determination of Paracetamol, Pseudoephedrine HCl, Dextromethorphan HBr, Doxylamine Succinate and Saccharin in Syrup Formulati	1