OOIR: Observatory of International Research

Papers

(The median citation count of Biochimica et Biophysica Acta-Proteins and Proteomics is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Co-chaperonin GroES subunit exchange as dependent on time, pH, protein concentration, and urea	64
Structure prediction and engineering of de novo proteins	32
TMB Stab-pred: Predicting the stability of transmembrane β-barrel proteins using their sequence and structural signatures	30
Structure of the complex of camel peptidoglycan recognition protein-S with hexanoic acid reveals novel features of the versatile ligand-binding site at the dimeric interface	25
Solution-based studies on the contact between the complement receptor 3 ligand-binding domain and simvastatin	22
The regulation of the thermal stability and affinity of the HSPA5 (Grp78/BiP) by clients and nucleotides is modulated by domains coupling	20
CDR identification, epitope mapping and binding affinity determination of novel monoclonal antibodies generated against human apolipoprotein B-100	19
Deep learning-based method for predicting and classifying the binding affinity of protein-protein complexes	19
Emerging roles of S100 proteins in podocyte biology and disease: A mini review	18
Active roles of lytic polysaccharide monooxygenases in human pathogenicity	18
Understanding Huntingtin protein aggregation in cell mimicking environments	17
Chemical proteomics approaches for protein post-translational modification studies	15
Beta-KTx14.3, a scorpion toxin, blocks the human potassium channel KCNQ1	14
The oxidative nuclease activity of human cytochrome c with mutations in Ω-loop C/D	13
Identification of new protein-coding potential in Leishmania braziliensis using a proteogenomics approach	13
An intermolecular hydrogen bonded network in the PRELID-TRIAP protein family plays a role in lipid sensing	13
Structure and functional studies of Avt1, a novel peptide from the sea anemone Aulactinia veratra	12
AP lyase activity of the human ribosomal protein uS3: The DNA cleavage sequence specificity and the location of the enzyme active center	12
Direct cryo-EM visualization of the β-sheet structure in curved amyloid protofibril	11
Activity-guided identification, cloning, heterologous expression, and characterization of a highly thermostable mitochondrial superoxide dismutase from Lantana camara	10
Green tea polyphenol EGCG acts differentially on end-stage amyloid polymorphs of α-synuclein formed in different polyol osmolytes	10
Epitope mapping of SARS-CoV-2 RBDs by hydroxyl radical protein footprinting reveals the importance of including negative antibody controls	10
A single amino acid difference between archaeal and human type 2 methionine aminopeptidases differentiates their affinity towards ovalicin	10
Bacteriophage-encoded chaperonins stimulate prion protein fibrillation in an ATP-dependent manner	9
Elucidation of multifunctionality and substrate specificity of human aspartate aminotransferases	9

Biochemical and kinetic properties of quinone oxidoreductase from Leishmania orientalis, a member of medium-chain dehydrogenase/reductase superfamily	9
Editorial Board	9
Flexibility in acidophilic thioredoxins: Insights from Asp43 substitutions in E. coli thioredoxin	9
Uncovering the membrane-integrated SecAN protein that plays a key role in translocating nascent outer membrane proteins	9
Structural-functional relevance of DNAJBs in protein aggregation and associated neurodegenerative diseases	8
Aqueous BSA-PEG solutions under repeated temperature cycles: Liquid-liquid phase separation and properties of the dispersed and condensed phases	8
Exploring human carboxylesterases 1 and 2 selectivity of two families of substrates at an atomistic level	8
Structure-guided engineering of serratiopeptidase using constant-pH molecular dynamics and site-directed mutagenesis to improve pH-dependent functional resilience	8
Corrigendum to ‘Glycoproteomic characterization of Neuropilin-1 reveals critical glycosylation sites for SARS-CoV-2 entry’ [Biochimica et Biophysica Acta (BBA) - proteins and proteomics 1873 (5) (2025	8
Identification of peptides interfering with the PP2Ac And LRRK2 interaction	8
Plumbagin accelerates serum albumin's amyloid aggregation kinetics and generates fibril polymorphism by inducing non-native β-sheet structures	8
Importance of aspartate 4 in the Mg2+ dependent regulation of Leishmania major PAS domain-containing phosphoglycerate kinase	8
Editorial Board	7
Aromatic interactions surrounding the Asp–X–Glu motif stabilize the active site of HYAL1 and PH20	7
Distinct dynamical features of plasmodial and human HSP70-HSP110 highlight the divergence in their chaperone-assisted protein folding	7
Disulfide-mediated dimerization stabilizes pyruvate kinase of Cryptosporidium parvum: Insights into unique structural assembly and functional implications	7
Citrus flavanone metabolites significantly modulate global proteomic profile in pancreatic β-cells under high-glucose-induced metabolic stress	7
Exploring liquid-liquid phase separation in the organisation of Golgi matrix proteins	6
The molecular basis of the antidepressant action of the magic mushroom extract, psilocin	6
FunPredCATH: An ensemble method for predicting protein function using CATH	6
Investigating protein aggregation in protein-carbohydrate interfaces using sequence and structural features	6
Evolution in neuropsychiatric cis-regulatory enhancers through human-specific neuronal mutations within transcription factor binding sites	6
Unravelling the phosphoregulatory network of protein kinase C-delta (PKC-δ)	6
The effect of pH and nitrite on the haem pocket of GLB-33, a globin-coupled neuronal transmembrane receptor of Caenorhabditis elegans	5
MS analysis of proteins concentrated on the surface of AFM chips from the blood plasma of healthy volunteers	5
Chemometric evaluation of key residues affecting the stability of cold shock proteins	5
Oxygen-carrying proteins employed in blood substitute candidates: differences in interactions with a model antioxidant molecule	5
FeoC from Klebsiella pneumoniae uses its iron sulfur cluster to regulate the GTPase activity of the ferrous iron channel	5
Biophysical characterization of Hpa1 protein from Xanthomonas orzyae	5
Substitution of carbonate by non-physiological synergistic anion modulates the stability and iron release kinetics of serum transferrin	5
Editorial Board	5
Propagation of conformational instability in FK506-binding protein FKBP12	5
Role of electrostatics in cold adaptation: A comparative study of eury- and stenopsychrophilic triose phosphate isomerase	4
Understanding LexA as a central regulator of the bacterial SOS response	4
Editorial Board	4
The effect of denaturants on protein thermal stability analyzed through a theoretical model considering multiple binding sites	4
Proteomic profiling of valproic acid-treated zebrafish embryos highlights dysregulation in energy and purine metabolism, and microtubule dynamics: Implications for autism spectrum disorder	4
Corrigendum to “Mass spectrometry analysis of the oxidation states of the pro oncogenic protein anterior gradient-2 reveals covalent dimerization via an intermolecular disulphide bond” [Biochimica et	4
Editorial Board	4
The apo-acyl coenzyme A binding protein of Leishmania major forms a unique ‘AXXA’ motif mediated dimer	4
Elucidating the inhibitory effects of rationally designed novel hexapeptide against hen egg white lysozyme fibrillation at acidic and physiological pH	4
Human apo-metallothionein 1a is not a random coil: Evidence from guanidinium chloride, high temperature, and acidic pH unfolding studies	4
Structural basis of nuclear transport for NEIL DNA glycosylases mediated by importin-alpha	4
Structure of the Borrelia burgdorferi ATP-dependent metalloprotease FtsH in its functionally relevant hexameric form	4
Phafin2 modulates the aggregation of NLRP3 on dispersed trans-Golgi network	4
Molecular insights into diosgenin's role in preventing protein aggregation in neurodegenerative diseases	4
Strategy for probing the functionality and stereoselectivity of enzyme active sites: Single sites, multiple sites versus multiple molecular forms, conformations, allozymes and isozymes	4
Drug–biomolecular interaction: Spectroscopic and computational insights into esomeprazole binding with human serum albumin	4
Development of β-sheet structure in Aβ aggregation intermediates diminishes exposed hydrophobic surface area and enhances proinflammatory activity	4
The structural basis of conserved residue variant effect on enzyme activity of UGT2B15	4

The Fe and Zn cofactor dilemma	3
NDM-1 Zn1-binding residue His116 plays critical roles in antibiotic hydrolysis	3
Structural conservation in the glutathione binding in Sphingomonas sp. glutaredoxin Grx3 and variations for cold adaptation	3
BthTX-I, a phospholipase A2-like toxin, is inhibited by the plant cinnamic acid derivative: chlorogenic acid	3
Nitrated products formed on α-synuclein are preferentially incorporated into oligomers but excluded from fibrils: A mechanism for accumulation of neurotoxic species	3
Identification of the interfacial regions in misfolded transthyretin oligomers	3
Identification of potential pharmacological chaperones that selectively stabilize mutated Aspartoacylases in Canavan disease	3
Full-size recombinant ORF1p-L1 and RT domain of ORF2p-L1: Protein expression, purification and characterization	3
Mapping the Periostin splice isoforms in atopic dermatitis and an in vitro asthma model – A multi-platform analysis using mass spectrometry and RT-qPCR	3
LncRNA CERS6 - AS1 mediates the IGF2BP1/LIN28B axis to promote proliferation, migration and invasion in ovarian cancer	3
Intrinsic affinity of protein – ligand binding by differential scanning calorimetry	3
Computing pathogenicity of mutations in human cytochrome P450 superfamily	3
AttnSeq-PPI: Enhancing protein-protein interaction network prediction using transfer learning-driven hybrid attention	3
Glycoproteomic characterization of Neuropilin-1 reveals critical glycosylation sites for SARS-CoV-2 entry	3
Integrated computational and biological assays to identify and validate L. donovani homoserine dehydrogenase inhibitors	3
Structural insights into the interaction between the BH3-like domain of hepatitis B virus X protein and LC3B	3
License to bind: Role of glycoproteins in male (in)fertility	2
Classification of binding property of amyloid β to lipid membranes: Membranomic research using quartz crystal microbalance combined with the immobilization of lipid planar membranes	2
Structural insights into the mechanism underlying the dual cofactor specificity of glyoxylate reductase from Acetobacter aceti in the β-hydroxyacid dehydrogenase family	2
Native structure of the monoclonal therapeutic CD20 antibody ocrelizumab	2
Native mass spectrometry for the investigation of protein structural (dis)order	2
Understanding the mechanism of amylin aggregation: From identifying crucial segments to tracing dominant sequential events to modeling potential aggregation suppressors	2
Multifunctionality analysis of serine hydroxymethyltransferases from human and Escherichia coli	2
Structural characterization of the type I-B CRISPR Cas7 from Thermobaculum terrenum	2
Heterotypic liquid-liquid phase separation of tau and α-synuclein: Implications for overlapping neuropathologies	2
Conformational and dynamic properties of the KH1 domain of FMRP and its fragile X syndrome linked G266E variant	2
Electrochemical enzyme biosensing reveals differential abundance of GPI-anchored metalloprotease across Leishmania (Viannia) braziliensis subpopulations	2
Insights into key kinase regulatory network of LARP1 based on co-occurring phosphorylation events	2
Cd-induced cytosolic proteome changes in the cyanobacterium Anabaena sp. PCC7120 are mediated by LexA as one of the regulatory proteins	2
Tracking heme biology with resonance Raman spectroscopy	2
Crystal structure of thymidine kinase from the multi-drug resistant col strain of Staphylococcus aureus	2
Enzymatic and biophysical characterization of a novel modular cellulosomal GH5 endoglucanase multifunctional from the anaerobic gut fungus Piromyces finnis	2
Cytotoxicity originates at the amorphous intermediate stage during amyloid-like oligomerization of serum albumin under mild denaturing conditions	2
The regulation of RGLG2-VWA by Ca2+ ions	2
Polyol and sugar osmolytes stabilize the molten globule state of α-lactalbumin and inhibit amyloid fibril formation	1
Peptide from NSP7 is able to form amyloid-like fibrils: Artifact or challenge to drug design?	1
Biophysical analysis of SECIS binding protein 2 (SBP2) from Naegleria gruberi	1
DSP-1, the major fibronectin type-II protein of donkey seminal plasma is a small heat-shock protein and exhibits chaperone-like activity against thermal and oxidative stress	1
Self-association of Apolipoprotein A-I studied with multiple-association models: A pyrene multiparametric analysis	1
Biophysical characterization of human-cell-expressed, full-length κI O18/O8, AL-09, λ6a, and Wil immunoglobulin light chains	1
Efficient production of a novel recombinant fusion protein of EIEC effector IpaD and EGFP: Biophysical characterization and functional studies	1
Deciphering the cleavage sites of 3C-like protease in Gammacoronaviruses and Deltacoronaviruses	1
Computational phosphoproteomic insights into predominant BRAF phosphosites and associated regulatory networks in cancer	1
The explorations of dynamic interactions of paxillin at the focal adhesions	1
Production of recombinant lytic polysaccharide monooxygenases and evaluation effect of its addition into Aspergillus fumigatus var. niveus cocktail for sugarcane bagasse saccharification	1
Incorporation of pyridoxal-5′-phosphate into the apoenzyme: A structural study of D-amino acid transaminase from Haliscomenobacter hydrossis	1
Oligomeric state of the N-terminal domain of DnaT for replication restart in Escherichia coli	1
CRUMBS-associated mutations in Retinitis Pigmentosa and its impact on molecular scaffolding	1
Molecular dynamics simulations suggest Thiosemicarbazones can bind p53 cancer mutant R175H	1
Effect of tubulin self-association on GTP hydrolysis and nucleotide exchange reactions	1
Editorial Board	1
The role of the N-terminal p.R56Q mutation in modulating oligomerization and chaperone activity of human αB-crystallin in relation to cardiomyopathy	1
Metaviromics analysis of marine biofilm reveals a glycoside hydrolase endolysin with high specificity towards Acinetobacter baumannii	1
Calcium dependence and biochemical characterization of metacaspase-3 from Trypanosoma cruzi	1
Robust assessment of sample preparation protocols for proteomics of cells and tissues	1
Assigning roles in Chlamydomonas ribosome biogenesis: The conserved factor NIP7	1
Arg236 in human chymotrypsin B2 (CTRB2) is a key determinant of high enzyme activity, trypsinogen degradation capacity, and protection against pancreatitis	1
The structural and functional consequences of melatonin and serotonin on human αB-crystallin and their dual role in the eye lens transparency	1
Biochemical characterization and assay development for adenylosuccinate synthetase Rv0357c from Mycobacterium tuberculosis	1
Structural insights of the complex formed by KRAS G12V and a novel TIG3 peptide	1
Deciphering the structural attributes of PPAR-γ and SIRT1 to identify their dual activators using a combined molecular modeling approach	1
DUSP15 exhibits structural and dynamical signatures inconsistent with catalytic phosphatase activity	1
A short structural extension dictates the early stages of folding of a PDZ domain	1
Comparative proteomic profiling of advanced, injectable, and titanium-prepared platelet rich fibrins (PRF): Insights into functional divergence and clinical potential	1
A dissected non-ribosomal peptide synthetase maintains activity	1
The anti-platelet drug ticlopidine inhibits FapC fibrillation and biofilm production: Highlighting its antibiotic activity	1
Role of N-terminal of metacaspase of Candida albicans in calcium binding.	1
Modulation of α-synuclein phase separation by biomolecules	1
Amyloid-β aggregates induced by β-cholesteryl glucose-embedded liposomes	1
Engineering of conserved residues near antibody heavy chain complementary determining region 3 (HCDR3) improves both affinity and stability	1
Structural basis for the allosteric behaviour and substrate specificity of Lactococcus lactis Prolidase	1
Mechanistic aspects of the transamination reactions catalyzed by D-amino acid transaminase from Haliscomenobacter hydrossis	1
Characterization of E121K mutation of D-amino acid oxidase – Insights into mechanisms leading to amyotrophic lateral sclerosis	1