Current Neuropharmacology

Article	Citations
Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease	335
Role of Nuclear Factor Kappa B (NF-κB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach	160
Crosstalk between Inflammation and the BBB in Stroke	94
Understanding the Role of Histone Deacetylase and their Inhibitors in Neurodegenerative Disorders: Current Targets and Future Perspective	87
Angiogenesis and Blood-Brain Barrier Permeability in Vascular Remodeling after Stroke	83
Effects of Withania somnifera (Ashwagandha) on Stress and the Stress- Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia	71
A Scientometrics Analysis and Visualization of Depressive Disorder	64
Ultramicronized Palmitoylethanolamide and Luteolin Supplement Combined with Olfactory Training to Treat Post-COVID-19 Olfactory Impairment: A Multi-Center Double-Blinded Randomized Placebo- Controlled	60
The Multifaceted Therapeutic Role of N-Acetylcysteine (NAC) in Disorders Characterized by Oxidative Stress	58
The Dual Role of Microglia in Blood-Brain Barrier Dysfunction after Stroke	53
Role of Nitric Oxide in Neurodegeneration: Function, Regulation, and Inhibition	53
Depression and Pain: Use of Antidepressants	50
Mitochondrial Dysfunction in Alzheimer’s Disease: Opportunities for Drug Development	50
PTSD in the COVID-19 Era	50
Potential Mechanisms and Clinical Effectiveness of Acupuncture in Depression	48
The Stroke-Induced Blood-Brain Barrier Disruption: Current Progress of Inspection Technique, Mechanism, and Therapeutic Target	48
Temozolomide: An Updated Overview of Resistance Mechanisms, Nanotechnology Advances and Clinical Applications	47
Exosomes as a Promising Therapeutic Strategy for Peripheral Nerve Injury	43
5-HT3 Receptor Antagonism: A Potential Therapeutic Approach for the Treatment of Depression and other Disorders	42
Expanding the Arsenal Against Huntington's Disease-Herbal Drugs and Their Nanoformulations	41
Neuroinflammation in Huntington’s Disease: A Starring Role for Astrocyte and Microglia	38
Mitochondrion as a Selective Target for the Treatment of Atherosclerosis: Role of Mitochondrial DNA Mutations and Defective Mitophagy in the Pathogenesis of Atherosclerosis and Chronic Inflammation	38
Neuroinflammatory Signaling in the Pathogenesis of Alzheimer’s Disease	37
Glia-Driven Neuroinflammation and Systemic Inflammation in Alzheimer’s Disease	37
C-Phycocyanin-derived Phycocyanobilin as a Potential Nutraceutical Approach for Major Neurodegenerative Disorders and COVID-19- induced Damage to the Nervous System	34

The Effects of General Anesthetics on Synaptic Transmission	33
Treatment of Posttraumatic Stress Disorder: A State-of-the-art Review	33
Recent Evidence in Epigenomics and Proteomics Biomarkers for Early and Minimally Invasive Diagnosis of Alzheimer’s and Parkinson’s Diseases	33
The Role of Mitochondrial Impairment in Alzheimer´s Disease Neurodegeneration: The Tau Connection	31
Association of Oxidative Stress with Neurological Disorders	31
Underlying Mechanisms and Potential Therapeutic Molecular Targets in Blood-Brain Barrier Disruption after Subarachnoid Hemorrhage	31
Inhibition of Caspase 3 and Caspase 9 Mediated Apoptosis: A Multimodal Therapeutic Target in Traumatic Brain Injury	31
Off-label Uses of Selective Serotonin Reuptake Inhibitors (SSRIs)	31
Targeting S100B Protein as a Surrogate Biomarker and its Role in Various Neurological Disorders	30
Tetrahydrobioterin (BH4) Pathway: From Metabolism to Neuropsychiatry	29
New Mechanisms and Targets of Subarachnoid Hemorrhage: A Focus on Mitochondria	29
Gut Microbiota Regulate Astrocytic Functions in the Brain: Possible Therapeutic Consequences	29
cGAS-STING-mediated IFN-I Response in Host Defense and Neuroinflammatory Diseases	29
Neurodegenerative Pathways in Alzheimer’s Disease: A Review	29
Therapeutic and Mechanistic Effects of Curcumin in Huntington’s Disease	27
Progression in Moyamoya Disease: Clinical Features, Neuroimaging Evaluation, and Treatment	27
The Role of Autophagy in the Pathogenesis of Ischemic Stroke	26
Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin Norepinephrine Reuptake Inhibitors (SNRIs) During Pregnancy and the Risk for Autism spectrum disorder (ASD) and Attention deficit hyperact	26
Linalool as a Therapeutic and Medicinal Tool in Depression Treatment: A Review	26
Management Perspective of Wilson’s Disease: Early Diagnosis and Individualized Therapy	26
Pharmacological and Non-pharmacological Treatments of Sleep Disorders in Parkinson's Disease	25
Elucidating the Potential Side Effects of Current Anti-Seizure Drugs for Epilepsy	25
The Links between Cardiovascular Diseases and Alzheimer's Disease	25
Dysregulation of the Gut-Brain Axis, Dysbiosis and Influence of Numerous Factors on Gut Microbiota Associated Parkinson’s Disease	25
Neural Substrates for the Regulation of Sleep and General Anesthesia	24
Effects of Histone Modification in Major Depressive Disorder	23
Neurochemical and Behavioral Consequences of Ethanol and/or Caffeine Exposure: Effects in Zebrafish and Rodents	21
The Dawn of Mitophagy: What Do We Know by Now?	21
SIRT1 Promotes Neuronal Fortification in Neurodegenerative Diseases through Attenuation of Pathological Hallmarks and Enhancement of Cellular Lifespan	21
Behavioral Tasks Evaluating Schizophrenia-like Symptoms in Animal Models: A Recent Update	21
Neuroprotective Effects of Neuropeptide Y against Neurodegenerative Disease	21
PLGA-Based Curcumin Delivery System: An Interesting Therapeutic Approach in the Treatment of Alzheimer’s Disease	20
The Updated Role of the Blood Brain Barrier in Subarachnoid Hemorrhage: From Basic and Clinical Studies	20
Hydrogen Sulfide (H2S) Signaling as a Protective Mechanism against Endogenous and Exogenous Neurotoxicants	20
Crocus Sativus L. (Saffron) in Alzheimer’s Disease Treatment: Bioactive Effects on Cognitive Impairment	20
Nanotechnological Advances for Nose to Brain Delivery of Therapeutics to Improve the Parkinson Therapy	20
Acid-Sensing Ion Channels: Focus on Physiological and Some Pathological Roles in the Brain	20
Effects of General Anesthetics on Synaptic Transmission and Plasticity	19
Chlorogenic Acid Improves PTSD-like Symptoms and Associated Mechanisms	19
Challenges of Delirium Management in Patients with Traumatic Brain Injury: From Pathophysiology to Clinical Practice	19
Current and Emerging Treatments for Methamphetamine Use Disorder	19
Emerging Evidence for Neuropsycho-Consequences of COVID-19	19
BACE1: A Key Regulator in Alzheimer’s Disease Progression and Current Development of its Inhibitors	19
Targeting Brain-spleen Crosstalk After Stroke: New Insights Into Stroke Pathology and Treatment	19
Sleep Disturbances and Cognitive Impairment in the Course of Type 2 Diabetes-A Possible Link	19
Role of Hydrogen Sulfide and Polysulfides in Neurological Diseases: Focus on Protein S-Persulfidation	19
Synthetic Cannabinoids and Cathinones Cardiotoxicity: Facts and Perspectives	19
Effects of Risperidone in Autistic Children and Young Adults: A Systematic Review and Meta-Analysis	18
Interaction between Zinc, GPR39, BDNF and Neuropeptides in Depression	18
Phytocannabinoids: General Aspects and Pharmacological Potential in Neurodegenerative Diseases	18

Plant-Derived Natural Compounds for the Treatment of Amyotrophic Lateral Sclerosis: An Update	18
Current Understanding of Central Nervous System Drainage Systems: Implications in the Context of Neurodegenerative Diseases	18
Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmac	18
From the Molecular Mechanism to Pre-clinical Results: Anti-epileptic Effects of Fingolimod	17
Src Family Kinases in the Central Nervous System: Their Emerging Role in Pathophysiology of Migraine and Neuropathic Pain	17
Beyond its Psychiatric Use: The Benefits of Low-dose Lithium Supplementation	17
Ketogenic Diet: An Effective Treatment Approach for Neurodegenerative Diseases	17
Nerve Growth Factor in Alcohol Use Disorders	17
The Potential Role of Hypoxia-Inducible Factor-1 in the Progression and Therapy of Central Nervous System Diseases	17
Xenogeneic Decellularized Extracellular Matrix-based Biomaterials For Peripheral Nerve Repair and Regeneration	17
Adolescent Substance Abuse, Transgenerational Consequences and Epigenetics	17
MicroRNAs in the Blood-Brain Barrier in Hypoxic-Ischemic Brain Injury	17
7,8-Dihydroxyflavone and Neuropsychiatric Disorders: A Translational Perspective from the Mechanism to Drug Development	17
Phytochemicals Targeting Oxidative Stress, Interconnected Neuroinflammatory, and Neuroapoptotic Pathways Following Radiation	16
Immune Checkpoint Inhibitors and Neurotoxicity	16
The Brain-gut Axis-where are we now and how can we Modulate these Connections?	16
Biomedical Perspectives of Acute and Chronic Neurological and Neuropsychiatric Sequelae of COVID-19	16
Neuroprotective Potential of Caffeic Acid Phenethyl Ester (CAPE) in CNS Disorders: Mechanistic and Therapeutic Insights	16
Crosstalk between Microglia and Neurons in Neurotrauma: An Overview of the Underlying Mechanisms	16
Pharmacologic Treatment of Restless Legs Syndrome	16
Autophagy & Phagocytosis in Neurological Disorders and their Possible Cross-talk	16
Drug Delivery Nanosystems in Glioblastoma Multiforme Treatment: Current State of the Art	16
Novel Synthetic and Natural Therapies for Traumatic Brain Injury	16
Effects of Di-2-Ethylhexyl Phthalate on Central Nervous System Functions: A Narrative Review	15
Tyrosol as a Neuroprotector: Strong Effects of a “Weak” Antioxidant	15
Protective Effects of Dendrobium nobile Lindl. Alkaloids on Alzheimer's Disease-like Symptoms Induced by High-methionine Diet	15
Role of Gut Microbiota in Multiple Sclerosis and Potential Therapeutic Implications	15
Is It the Twilight of BACE1 Inhibitors?	15
Peripheral and Central Glutamate Dyshomeostasis in Neurodegenerative Disorders	15
Anti-IL-6 Therapies for Neuromyelitis Optica Spectrum Disorders: A Systematic Review of Safety and Efficacy	15
Effects of Mulberry on The Central Nervous System: A Literature Review	15
The e-Psychonauts’ ‘Spiced’ World; Assessment of the Synthetic Cannabinoids’ Information Available Online	15
Cholecystokinin-Mediated Neuromodulation of Anxiety and Schizophrenia: A “Dimmer-Switch” Hypothesis	15
siRNA Therapeutics: Future Promise for Neurodegenerative Diseases	15
Targeting Glioblastoma: The Current State of Different Therapeutic Approaches	14
Circadian Rhythm Disruption and Alzheimer’s Disease: The Dynamics of a Vicious Cycle	14
The Emerging Role of the Double-Edged Impact of Arachidonic Acid- Derived Eicosanoids in the Neuroinflammatory Background of Depression.	14
Dapsone, More than an Effective Neuro and Cytoprotective Drug	14
Green Tea, A Medicinal Food with Promising Neurological Benefits	14
Therapeutic Potential of Multifunctional Derivatives of Cholinesterase Inhibitors	14
Is Adult Hippocampal Neurogenesis Really Relevant for the Treatment of Psychiatric Disorders?	14
Treatment of Circadian Rhythm Sleep–Wake Disorders	14
The Complexity of Secondary Cascade Consequent to Traumatic Brain Injury: Pathobiology and Potential Treatments	14
Epilepsy and Cognitive Impairment in Childhood and Adolescence: A Mini-Review	13
Advances in the Pharmacological and Non-pharmacological Management of Non-motor Symptoms in Parkinson’s Disease: An Update Since 2017	13
The Investigation into Neurotoxicity Mechanisms of Nonylphenol: A Narrative Review	13
Post-Translational Modifications of BACE1 in Alzheimer's Disease	13
Melatonin as a Chronobiotic with Sleep-promoting Properties	13
Resveratrol-Mediated Regulation of Mitochondria Biogenesis-associated Pathways in Neurodegenerative Diseases: Molecular Insights and Potential Therapeutic Applications	13
The Role of Voltage-Gated Calcium Channels in Basal Ganglia Neurodegenerative Disorders	13
Fabry Disease: Current and Novel Therapeutic Strategies. A Narrative Review	13
Bidirectional Communication Between Microglia and Astrocytes in Neuroinflammation	13
Uncoupling Protein 2 as a Pathogenic Determinant and Therapeutic Target in Cardiovascular and Metabolic Diseases	12
Cholinesterase Inhibitory Potential of Quercetin towards Alzheimer’s Disease - A Promising Natural Molecule or Fashion of the Day? - A Narrowed Review	12
Depression: An Insight into Heterocyclic and Cyclic Hydrocarbon Compounds Inspired from Natural Sources	12
Interplay of BDNF and GDNF in the Mature Spinal Somatosensory System and Its Potential Therapeutic Relevance	12
Pharmacological Strategy for Congenital Myasthenic Syndrome with CHRNE Mutations: A Meta-Analysis of Case Reports	12
Voxel-wise Functional Connectivity of the Default Mode Network in Epilepsies: A Systematic Review and Meta-Analysis	12
Hexahydrocannabinol Pharmacology, Toxicology, and Analysis: The First Evidence for a Recent New Psychoactive Substance	12
Identifying c-fos Expression as a Strategy to Investigate the Actions of General Anesthetics on the Central Nervous System	12
Neurodevelopment Following Exposure to Antiseizure Medications in Utero: A Review	12
Natural Product-based Nanomedicine: Recent Advances and Issues for the Treatment of Alzheimer's Disease	12
Modulation of Gut-Brain Axis by Probiotics: A Promising Anti-depressant Approach	12
Antioxidant Enzymes and Weight Gain in Drug-naive First-episode Schizophrenia Patients Treated with Risperidone for 12 Weeks: A Prospective Longitudinal Study	12
Early Biomarkers and Intervention Programs for the Infant Exposed to Prenatal Stress	12
The HPA Axis as Target for Depression	12
C-terminus of Hsp70 Interacting Protein (CHIP) and Neurodegeneration: Lessons from the Bench and Bedside	12
Therapeutic Strategies to Protect the Central Nervous System against Shiga Toxin from Enterohemorrhagic Escherichia coli	12
The Effects of Drugs used for the Treatment of Attention Deficit Hyperactivity Disorder (ADHD) on Pregnancy Outcome and Breast-feeding: A Critical Review	12
Association Between the COMT Val158Met Polymorphism and Antipsychotic Efficacy in Schizophrenia: An Updated Meta-Analysis	11
Inflammation Drives Alzheimer's Disease: Emphasis on 5-lipoxygenase Pathways	11
Poloxamer 188 (P188), A Potential Polymeric Protective Agent for Central Nervous System Disorders: A Systematic Review	11
Glutamate NMDA Receptor Antagonists with Relevance to Schizophrenia: A Review of Zebrafish Behavioral Studies	11
Receptors for Advanced Glycation End Products (RAGE): Promising Targets Aiming at the Treatment of Neurodegenerative Conditions	11
A Healthy Gut for a Healthy Brain: Preclinical, Clinical and Regulatory Aspects	11
The Role of Astrogliosis in Formation of the Syrinx in Spinal Cord Injury	11
Herb-drug Interactions in Neuropsychiatric Pharmacotherapy – A Review of Clinically Relevant Findings	11
Sex-Specific Association between Antioxidant Defense System and Therapeutic Response to Risperidone in Schizophrenia: A Prospective Longitudinal Study	11
Protective Effects of Polydatin Against Dementia-Related Disorders	11
Overview of Chemistry and Therapeutic Potential of Non-Nitrogen Heterocyclics as Anticonvulsant Agents	11

Targeting Ionotropic Glutamate Receptors in the Treatment of Epilepsy	11
Neutrophil Heterogeneity and its Roles in the Inflammatory Network after Ischemic Stroke	11
Implication of Hippocampal Neurogenesis in Autism Spectrum Disorder: Pathogenesis and Therapeutic Implications	11
Pathways Involved in Remyelination after Cerebral Ischemia	11
Comparative Analysis of the Pre- and Post-Medication Effects of Antipsychotic Agents on the Blood-Based Oxidative Stress Biomarkers in Patients with Schizophrenia: A Meta-Analysis	11
Alzheimer’s Disease: New Concepts on the Role of Autoimmunity and NLRP3 Inflammasome in the Pathogenesis of the Disease	11
The Gut-Brain Axis and the Microbiome in Anxiety Disorders, Post-Traumatic Stress Disorder and Obsessive-Compulsive Disorder	10
Microtubule-modulating Agents in the Fight Against Neurodegeneration: Will it ever Work?	10
The Role of Stem Cells in the Therapy of Stroke	10
Transgenerational Abnormalities Induced by Paternal Preconceptual Alcohol Drinking: Findings from Humans and Animal Models	10
Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders	10
Use of Zebrafish Genetic Models to Study Etiology of the Amyloid-Beta and Neurofibrillary Tangle Pathways in Alzheimer's Disease	10
Treatment of Autism Spectrum Disorders by Mitochondrial-targeted Drug: Future of Neurological Diseases Therapeutics	10
Current Clinical Psychopharmacology in Borderline Personality Disorder	10
Targeting Options of Tumor-Associated Macrophages (TAM) Activity in Gliomas	10
How to Optimize the Effectiveness and Safety of Parkinson’s Disease Therapy? – A Systematic Review of Drugs Interactions with Food and Dietary Supplements	10
A Review of Artificial Intelligence in Cerebrovascular Disease Imaging: Applications and Challenges	10
Patients Stratification Strategies to Optimize the Effectiveness of Scavenging Biogenic Aldehydes: Towards a Neuroprotective Approach for Parkinson's Disease	10
Nanocarrier-Based Drug Delivery to Brain: Interventions of Surface Modification	10
Cholinergic Modulation of General Anesthesia	10
Building Resilience with Aerobic Exercise: Role of FKBP5	10
The Role of Neuroglial Metabotropic Glutamate Receptors in Alzheimer’s Disease	10
Stem Cell-based Therapeutic and Diagnostic Approaches in Alzheimer's Disease	10
Depression as an Immunometabolic Disorder: Exploring Shared Pharmacotherapeutics with Cardiovascular Disease	10
Current Strategies for Promoting the Large-scale Production of Exosomes	10
Sceletium for Managing Anxiety, Depression and Cognitive Impairment: A Traditional Herbal Medicine in Modern-Day Regulatory Systems	10
The Role of Nrf2 in Relieving Cerebral Ischemia-Reperfusion Injury	10