OOIR: Observatory of International Research

Papers

(The TQCC of DNA Repair is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
ADP-ribosylation of DNA and RNA	65
Defining R-loop classes and their contributions to genome instability	63
Biomolecular condensates at sites of DNA damage: More than just a phase	62
Recent advances in γH2AX biomarker-based genotoxicity assays: A marker of DNA damage and repair	59
Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair	42
PARP1: Structural insights and pharmacological targets for inhibition	39
Towards DNA-damage induced autophagy: A Boolean model of p53-induced cell fate mechanisms	38
Revisiting the BRCA-pathway through the lens of replication gap suppression	37
Towards a comprehensive view of 8-oxo-7,8-dihydro-2’-deoxyguanosine: Highlighting the intertwined roles of DNA damage and epigenetics in genomic instability	36
The cerebellar degeneration in ataxia-telangiectasia: A case for genome instability	36
Strand discrimination in DNA mismatch repair	34
Dealing with transcription-blocking DNA damage: Repair mechanisms, RNA polymerase II processing and human disorders	33
Targeting Wee1 kinase as a therapeutic approach in Hematological Malignancies	33
Coping with RNA damage with a focus on APE1, a BER enzyme at the crossroad between DNA damage repair and RNA processing/decay	31
Time for remodeling: SNF2-family DNA translocases in replication fork metabolism and human disease	29
P53 in the impaired lungs	29
The dark side of homology-directed repair	28
The evolving complexity of DNA damage foci: RNA, condensates and chromatin in DNA double-strand break repair	28
Roles for MDC1 in cancer development and treatment	28
The SNM1A DNA repair nuclease	27
DNA damage response and repair in osteosarcoma: Defects, regulation and therapeutic implications	26
Transcription-coupled nucleotide excision repair: New insights revealed by genomic approaches	25
Signaling pathways involved in cell cycle arrest during the DNA breaks	25
GTPases, genome, actin: A hidden story in DNA damage response and repair mechanisms	24
Transcription coupled base excision repair in mammalian cells: So little is known and so much to uncover	24

DNA helicases and their roles in cancer	23
PRMT1 is critical to FEN1 expression and drug resistance in lung cancer cells	23
CST in maintaining genome stability: Beyond telomeres	23
Cellular response to endogenous DNA damage: DNA base modifications in gene expression regulation	23
Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1	23
The dual role of DNA repair protein MGMT in cancer prevention and treatment	23
Impact of circadian disruption on health; SIRT1 and Telomeres	22
Mechanisms of direct replication restart at stressed replisomes	22
The role of histone H3K36me3 writers, readers and erasers in maintaining genome stability	22
Toxic R-loops: Cause or consequence of replication stress?	21
Transcription-coupled DNA double-strand break repair	21
Formation and repair of unavoidable, endogenous interstrand cross-links in cellular DNA	21
Significance and limitations of the use of next-generation sequencing technologies for detecting mutational signatures	20
Cancer testis antigens and genomic instability: More than immunology	20
Large dataset of octocoral mitochondrial genomes provides new insights into mt-mutS evolution and function	20
Pol β gap filling, DNA ligation and substrate-product channeling during base excision repair opposite oxidized 5-methylcytosine modifications	19
PARP1-mediated PARylation of TonEBP prevents R-loop–associated DNA damage	19
The role of telomeres and telomerase in the senescence of postmitotic cells	19
Increased DNA repair capacity augments resistance of glioblastoma cells to photodynamic therapy	19
C17orf53 is identified as a novel gene involved in inter-strand crosslink repair	18
mTOR pathway and DNA damage response: A therapeutic strategy in cancer therapy	18
Chaperoning histones at the DNA repair dance	18
Biochemical analysis of TOPBP1 oligomerization	18
HOTAIR beyond repression: In protein degradation, inflammation, DNA damage response, and cell signaling	18
Structure, function and evolution of the Helix-hairpin-Helix DNA glycosylase superfamily: Piecing together the evolutionary puzzle of DNA base damage repair mechanisms	17
The role of DNA damage response in chemo- and radio-resistance of cancer cells: Can DDR inhibitors sole the problem?	17
Replication initiation: Implications in genome integrity	17
RNA helicase, DDX3X, is actively recruited to sites of DNA damage in live cells	17
DNA double-strand break repair in male germ cells during spermatogenesis and its association with male infertility development	16
Transcription-coupled repair and the transcriptional response to UV-Irradiation	16
Daughter-strand gaps in DNA replication – substrates of lesion processing and initiators of distress signalling	16
Cyclin-dependent kinase inhibitors (CDKIs) and the DNA damage response: The link between signaling pathways and cancer	16
Understanding the DNA double-strand break repair and its therapeutic implications	15
New twists to the ALTernative endings at telomeres	15
DNA damage response and PD-1/PD-L1 pathway in ovarian cancer	15
The meiosis-specific MEIOB–SPATA22 complex cooperates with RPA to form a compacted mixed MEIOB/SPATA22/RPA/ssDNA complex	15
Role of histone acetyltransferases MOF and Tip60 in genome stability	15
Double-strand breaks: When DNA repair events accidentally meet	15
A DNA replication fork-centric view of the budding yeast DNA damage response	14
Non-canonical function of nuclear PTEN and its implication on tumorigenesis	14
Impacts of chromatin dynamics and compartmentalization on DNA repair	14
Compromised repair of radiation-induced DNA double-strand breaks in Fanconi anemia fibroblasts in G2	14
The cross-talk between signaling pathways, noncoding RNAs and DNA damage response: Emerging players in cancer progression	14
UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1	14
Perspectives on formaldehyde dysregulation: Mitochondrial DNA damage and repair in mammalian cells	14
Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes	14
Olaparib enhances curcumin-mediated apoptosis in oral cancer cells by inducing PARP trapping through modulation of BER and chromatin assembly	13
Double strand break (DSB) repair in Cyanobacteria: Understanding the process in an ancient organism	13
The multifaceted roles of DNA repair and replication proteins in aging and obesity	13
Sp1-dependent recruitment of the histone acetylase p300 to DSBs facilitates chromatin remodeling and recruitment of the NHEJ repair factor Ku70	13

Hydroxychloroquine induces oxidative DNA damage and mutation in mammalian cells	13
DNA damage response and breast cancer development: Possible therapeutic applications of ATR, ATM, PARP, BRCA1 inhibition	13
miR-197-5p increases Doxorubicin-mediated anticancer cytotoxicity of HT1080 fibrosarcoma cells by decreasing drug efflux	13
DNA repair pathways as guardians of the genome: Therapeutic potential and possible prognostic role in hematologic neoplasms	13
New insights into the DNA repair pathway choice with NuA4/TIP60	12
Alteration of genetic recombination and double-strand break repair in human cells by progerin expression	12
DNA damage and regulation of protein homeostasis	12
Histone variants: The unsung guardians of the genome	12
DNA polymerase β outperforms DNA polymerase γ in key mitochondrial base excision repair activities	12
MicroRNAs and the DNA damage response: How is cell fate determined?	12
Sequence context effects of replication of Fapy•dG in three mutational hot spot sequences of the p53 gene in human cells	11
Modulation of immune responses by DNA damage signaling	11
G-quadruplex resolution: From molecular mechanisms to physiological relevance	11
DNA damage-induced sumoylation of Sp1 induces its interaction with RNF4 and degradation in S phase to remove 53BP1 from DSBs and permit HR	11
Proficiency in homologous recombination repair is prerequisite for activation of G2-checkpoint at low radiation doses	11
USP13 regulates the replication stress response by deubiquitinating TopBP1	11
Molecular dynamics simulations reveal how H3K56 acetylation impacts nucleosome structure to promote DNA exposure for lesion sensing	11
PCNA, a focus on replication stress and the alternative lengthening of telomeres pathway	11
NELF complex fosters BRCA1 and RAD51 recruitment to DNA damage sites and modulates sensitivity to PARP inhibition	11
Paradoxical role of the major DNA repair protein, OGG1, in action-at-a-distance mutation induction by 8-oxo-7,8-dihydroguanine	11
Tissue-specific reduction in MLH1 expression induces microsatellite instability in intestine of Mlh1 mice	10
Analysis of mutational signatures in C. elegans: Implications for cancer genome analysis	10
Histone and Chromatin Dynamics Facilitating DNA repair	10
Genome maintenance during embryogenesis	10
Structural determinants of nucleobase modification recognition in the AlkB family of dioxygenases	10
Timely upstream events regulating nucleotide excision repair by ubiquitin-proteasome system: ubiquitin guides the way	10
Repair of DNA double-strand breaks in RNAPI- and RNAPII-transcribed loci	10
Post-translational modification of factors involved in homologous recombination	10
The FAcilitates Chromatin Transcription (FACT) complex: Its roles in DNA repair and implications for cancer therapy	10
Compartmentalization of the DNA damage response: Mechanisms and functions	9
Shining light on single-strand lesions caused by the chemotherapy drug bleomycin	9
The interactions between DNA methylation machinery and long non-coding RNAs in tumor progression and drug resistance	9
The DNA ligands Arg47 and Arg76 are crucial for catalysis by human PrimPol	9
The multifaceted functions of homologous recombination in dealing with replication-associated DNA damages	9
Mechanisms of genome stability maintenance during cell division	9
The RNF8 and RNF168 Ubiquitin Ligases Regulate Pro- and Anti-Resection Activities at Broken DNA Ends During Non-Homologous End Joining	9
Structure and mechanism in non-homologous end joining	9
To indel or not to indel: Factors influencing mutagenesis during chromosomal break end joining	9
Multi-omic analysis of altered transcriptome and epigenetic signatures in the UV-induced DNA damage response	9
The mRNA tether model for activation-induced deaminase and its relevance for Ig somatic hypermutation and class switch recombination	8
An open-source platform to quantify subnuclear foci and protein colocalization in response to replication stress	8
CometChip enables parallel analysis of multiple DNA repair activities	8
Insights into the Direct Oxidative Repair of Etheno Lesions: MD and QM/MM Study on the Substrate Scope of ALKBH2 and AlkB	8
DNA-protein crosslinks are repaired via homologous recombination in mammalian mitochondria	8
The fast-growing business of Serine ADP-ribosylation	8
Variation in G-quadruplex sequence and topology differentially impacts human DNA polymerase fidelity	8
RNA in DNA repair	8
Ubiquitylation in DNA double-strand break repair	8
The N-terminal domain of uracil-DNA glycosylase: Roles for disordered regions	8
Impact of DNA sequences on DNA ‘opening’ by the Rad4/XPC nucleotide excision repair complex	8
A novel DDB2 mutation causes defective recognition of UV-induced DNA damages and prevalent equine squamous cell carcinoma	8
Pan-cancer antagonistic inhibition pattern of ATM-driven G2/M checkpoint pathway vs other DNA repair pathways	8
Mechanisms of SSBP1 variants in mitochondrial disease: Molecular dynamics simulations reveal stable tetramers with altered DNA binding surfaces	8
Alternative complexes formed by the Escherichia coli clamp loader accessory protein HolC (x) with replication protein HolD (ψ) and repair protein YoaA	8
O-GlcNAc transferase is important for homology-directed repair	8
The burden of overweight: Higher body mass index, but not vital exhaustion, is associated with higher DNA damage and lower DNA repair capacity	8
Histone lysine modifying enzymes and their critical roles in DNA double-strand break repair	8
Histone variants H3.3 and H2A.Z/H3.3 facilitate excision of uracil from nucleosome core particles	8
Three targets in one complex: A molecular perspective of TFIIH in cancer therapy	8
Genome integrity and inflammation in the nervous system	8