OOIR: Observatory of International Research

Papers

(The TQCC of DNA Repair is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Active genome integrity	64
Activation of Escherichia coli RecA* in recA730 lexA+ and recA730 lexA(Def) strain backgrounds	55
Regulatory apoptotic fragment of PARP1 complements catalytic fragment for PAR and DNA-dependent activity but inhibits DNA-induced catalytic stimulation of PARP2	52
DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining	44
Building an integrated view of R-loops, transcription, and chromatin	41
Contents of previous 3 special issues in this series of perspectives	40
Spatial mapping of the DNA adducts in cancer	35
Functional defects of cancer-associated MDC1 mutations in DNA damage repair	34
Suppressors of Blm-deficiency identify three novel proteins that facilitate DNA repair in Ustilago maydis	28
Editors’ note Penny Jeggo and Bennett Van Houten	27
Single-molecule approaches for DNA damage detection and repair: A focus on Repair Assisted Damage Detection (RADD)	26
The burden of overweight: Higher body mass index, but not vital exhaustion, is associated with higher DNA damage and lower DNA repair capacity	25
Acetylation of H3K56 orchestrates UV-responsive chromatin events that generate DNA accessibility during Nucleotide Excision Repair	25
Single-molecule imaging of genome maintenance proteins encountering specific DNA sequences and structures	23
Harnessing R-loop dynamics: Challenging cancer therapy resistance	22
From cooperation to conflicts – A complicated relationship between transcription and replication	21
The role of human PrimPol active site residue Gln48 in catalysis and complex formation with DNA	21
Stressed? Break-induced replication comes to the rescue!	21
Irc20 modulates LOH frequency and distribution in S. cerevisiae	20
A novel Family V uracil DNA glycosylase from Sulfolobus islandicus REY15A	20
PARP1-PROTACs providing novel opportunities in precision oncology by targeting DNA damage response	19
Corruption of DNA end-joining in mammalian chromosomes by progerin expression	19
Chromatin meets the cytoskeleton: the importance of nuclear actin dynamics and associated motors for genome stability	18
Targeting base excision repair in precision oncology	18
Editorial Board	18

Positioning loss of PARP1 activity as the central toxic event in BRCA-deficient cancer	18
Editorial Board	18
Comparing Mfd- and UvrD-dependent models of transcription coupled DNA repair in live Escherichia coli using single-molecule tracking	17
What are the DNA lesions underlying formaldehyde toxicity?	17
The B cell dilemma: Diversity or fidelity?	17
DNA damage response and genomic instability disorder: Meeting report of the 20th Ataxia-Telangiectasia Workshop (ATW-2024) in conjunction with the 15th international symposium on DNA damage response &	17
DNA repair-related heritable photosensitivity syndromes: Mutation landscape in a multiethnic cohort of 17 multigenerational families with high degree of consanguinity	16
DNA synthesis across DNA hairpins by human PrimPol	16
Phospho-SIM and exon8b of PML protein regulate formation of doxorubicin-induced rDNA-PML compartment	16
PARP inhibitors in ovarian cancer: Mechanisms of resistance and implications to therapy	16
The differential roles of rad9 alternatively spliced forms in double- strand DNA break repair during Drosophila meiosis	16
The interferon response at the intersection of genome integrity and innate immunity	15
Protein-protein interactions in the core nucleotide excision repair pathway	15
The role of SLFN11 in DNA replication stress response and its implications for the Fanconi anemia pathway	15
Metazoan nuclear pore complexes in gene regulation and genome stability	15
Double-strand break repair and mis-repair in 3D	15
Editorial Board	15
Long-range PCR as a tool for evaluating mitochondrial DNA damage: Principles, benefits, and limitations of the technique	14
Centromere: A Trojan horse for genome stability	14
Editorial Board	14
Endogenous base damage as a driver of genomic instability in homologous recombination-deficient cancers	13
Camptothecin compromises transcription recovery and cell survival against cisplatin and ultraviolet irradiation regardless of transcription-coupled nucleotide excision repair	13
One-ended and two-ended breaks at nickase-broken replication forks	13
Expression of BRCA1, BRCA2, RAD51, and other DSB repair factors is regulated by CRL4WDR70	13
Impairment of the non-catalytic subunit Dpb2 of DNA Pol ɛ results in increased involvement of Pol δ on the leading strand	12
The multifaceted roles of the Ctf4 replisome hub in the maintenance of genome integrity	12
Chromosomal single-strand break repair and neurological disease: Implications on transcription and emerging genomic tools	12
Using the safety scissors: DNA resection regulation at DNA double-strand breaks and telomeres	12
NBS1 binds directly to TOPBP1 via disparate interactions between the NBS1 BRCT1 domain and the TOPBP1 BRCT1 and BRCT2 domains	12
Richard Gatti: From concert pianist to bone marrow transplants and the DNA damage response syndrome, ataxia-telangiectasia	12
Variation in G-quadruplex sequence and topology differentially impacts human DNA polymerase fidelity	12
Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory	12
Yearly perspective from the Co-Editors in Chief	11
miR-185–5p rewires cisplatin resistance by restoring miR-203a-3p expression via downregulation of SOX9	11
Biochemical characterization and mutational analysis of a mismatch glycosylase from the hyperthermophilic euryarchaeon Thermococcus barophilus Ch5	11
Inhibition of human DNA alkylation damage repair enzyme ALKBH2 by HIV protease inhibitor ritonavir	11
Somatic mutation patterns at Ig and Non-Ig Loci	11
Cutting Edge Perspectives in genome maintenance X	11
Altered lipid profile in mice lacking the DNA repair protein ERCC1	10
Frailty, sex, and poverty are associated with DNA damage and repair in frail, middle-aged urban adults	10
Reversible association of ubiquitin with PCNA is important for template switching in S. cerevisiae	10
Mechanisms and regulation of replication fork reversal	10
Presenilin-1, mutated in familial Alzheimer’s disease, maintains genome stability via a γ-secretase dependent way	10
Altered pathways in Cockayne syndrome: Involvement of MAPK, PI3K-Akt, extracellular matrix, inflammation, and neuronal signaling	10
Weaponizing CRISPR/Cas9 for selective elimination of cells with an aberrant genome	10
RNF4 prevents genomic instability caused by chronic DNA under-replication	10
How DNA secondary structures drive replication fork instability	10
C-terminal residues of DNA polymerase β and E3 ligase required for ubiquitin-linked proteolysis of oxidative DNA-protein crosslinks	10
Corrigendum to “Role of NEIL1 in genome maintenance” [DNA Repair 148 (2025) 103820]	10
BRCA1 and BRCA2 in DNA damage and replication stress response: Insights into their functions, mechanisms, and implications for cancer treatment	10

Small-molecule activator of SMUG1 enhances repair of pyrimidine lesions in DNA	10
A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein	10
The flap endonuclease-1 mediated maturation of Okazaki fragments is critical for the cellular tolerance to remdesivir	9
Editorial Board	9
Remdesivir triphosphate is a valid substrate to initiate synthesis of DNA primers by human PrimPol	9
Probing the structure and function of polymerase θ helicase-like domain	9
Contents of previous 3 special issues in this series of perspectives	9
Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhances alkylating agent and PARG inhibition induced cytotoxicity	9
Editorial Board	9
Obituary	9
Mlh1 interacts with both Msh2 and Msh6 for recruitment during mismatch repair	9
Insight into meiotic DNA end resection: Mechanisms and regulation	9
DNA Repair Special Issue: Genome maintenance pathways in cancer - etiology, biomarkers and targets	9
KBM-mediated interactions with KU80 promote cellular resistance to DNA replication stress in CHO cells	9
Regulation of DNA damage-induced HLA class I presentation	9
TFIIH central activity in nucleotide excision repair to prevent disease	9
Tribute to life and science of Grigory (Gosha) Dianov	8
Low and high doses of ionizing radiation evoke discrete global (phospho)proteome responses	8
Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication	8
The replication stress response: Mechanisms and functions	8
DNA lesions that block transcription induce the death of Trypanosoma cruzi via ATR activation, which is dependent on the presence of R-loops	8
Genome integrity and inflammation in the nervous system	8
Variants in the first methionine of RAD51C are homologous recombination proficient due to an alternative start site	8
A special issue: DNA damage response in disease and therapy	8
Therapeutic targeting of mismatch repair proteins in triplet repeat expansion diseases	8
Screening of glycosylase activity on oxidative derivatives of methylcytosine: Pedobacter heparinus SMUG2 as a formylcytosine- and carboxylcytosine-DNA glycosylase	8
Biochemical characterization and mutational studies of endonuclease Q from the hyperthermophilic euryarchaeon Thermococcus gammatolerans	8
Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates	8
USP1 in regulation of DNA repair pathways	8
Cutting edge perspectives in genome maintenance XI	8
SMC-5/6 complex subunit NSE-1 plays a crucial role in meiosis and DNA repair in Caenorhabditis elegans	8
Discovery of KPT-6566 as STAG1/2 Inhibitor sensitizing PARP and NHEJ Inhibitors to suppress tumor cells growth in vitro	8