DNA Repair

(The TQCC of DNA Repair is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)
New insights into abasic site repair and tolerance85
Cancer type-dependent correlations between TP53 mutations and antitumor immunity82
Excision repair of topoisomerase DNA-protein crosslinks (TOP-DPC)60
Roles for 53BP1 in the repair of radiation-induced DNA double strand breaks60
The MRE11 complex: A versatile toolkit for the repair of broken DNA58
Mammalian DNA base excision repair: Dancing in the moonlight56
Biomolecular condensates at sites of DNA damage: More than just a phase52
Defining R-loop classes and their contributions to genome instability49
Debulking of topoisomerase DNA-protein crosslinks (TOP-DPC) by the proteasome, non-proteasomal and non-proteolytic pathways48
ADP-ribosylation of DNA and RNA48
Recent advances in γH2AX biomarker-based genotoxicity assays: A marker of DNA damage and repair47
Molecular origins of APOBEC-associated mutations in cancer45
DNA mismatch repair-dependent DNA damage responses and cancer40
Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair37
DNA-protein crosslink formation by endogenous aldehydes and AP sites37
The recent advances in non-homologous end-joining through the lens of lymphocyte development36
The cerebellar degeneration in ataxia-telangiectasia: A case for genome instability34
Towards DNA-damage induced autophagy: A Boolean model of p53-induced cell fate mechanisms33
PARP1: Structural insights and pharmacological targets for inhibition33
Targeting Wee1 kinase as a therapeutic approach in Hematological Malignancies32
Towards a comprehensive view of 8-oxo-7,8-dihydro-2’-deoxyguanosine: Highlighting the intertwined roles of DNA damage and epigenetics in genomic instability32
Strand discrimination in DNA mismatch repair31
Consequences of compromised mitochondrial genome integrity30
Coping with RNA damage with a focus on APE1, a BER enzyme at the crossroad between DNA damage repair and RNA processing/decay29
How to fix DNA-protein crosslinks29
The role of the SWI/SNF chromatin remodelling complex in the response to DNA double strand breaks27
Human DNA ligases in replication and repair26
Time for remodeling: SNF2-family DNA translocases in replication fork metabolism and human disease26
XRCC1 – Strategies for coordinating and assembling a versatile DNA damage response25
Dealing with transcription-blocking DNA damage: Repair mechanisms, RNA polymerase II processing and human disorders25
The evolving complexity of DNA damage foci: RNA, condensates and chromatin in DNA double-strand break repair25
Role of mtDNA disturbances in the pathogenesis of Alzheimer’s and Parkinson’s disease25
TREX1 – Apex predator of cytosolic DNA metabolism25
Roles for MDC1 in cancer development and treatment24
Revisiting the BRCA-pathway through the lens of replication gap suppression24
PARPs’ impact on base excision DNA repair24
P53 in the impaired lungs24
The SNM1A DNA repair nuclease23
DNA damage response and repair in osteosarcoma: Defects, regulation and therapeutic implications23
Hypermutation in single-stranded DNA23
Signaling pathways involved in cell cycle arrest during the DNA breaks23
Transcription-coupled nucleotide excision repair: New insights revealed by genomic approaches22
NAD+-mediated regulation of mammalian base excision repair22
EXO1: A tightly regulated nuclease22
Cellular response to endogenous DNA damage: DNA base modifications in gene expression regulation22
Twenty years of t-loops: A case study for the importance of collaboration in molecular biology21
PRMT1 is critical to FEN1 expression and drug resistance in lung cancer cells21
Expanding molecular roles of UV-DDB: Shining light on genome stability and cancer21
NTHL1 in genomic integrity, aging and cancer21
Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP120
DNA helicases and their roles in cancer20
Impact of circadian disruption on health; SIRT1 and Telomeres20
GTPases, genome, actin: A hidden story in DNA damage response and repair mechanisms19
Transcription coupled base excision repair in mammalian cells: So little is known and so much to uncover19
Two main mutational processes operate in the absence of DNA mismatch repair19
Chromosome breaks generated by low doses of ionizing radiation in G2-phase are processed exclusively by gene conversion19
Understanding the sequence and structural context effects in oxidative DNA damage repair18
Mechanisms of direct replication restart at stressed replisomes17
The dark side of homology-directed repair17
Increased DNA repair capacity augments resistance of glioblastoma cells to photodynamic therapy17
Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase 1 DNA-protein crosslinks and 3′-blocking lesions in the absence of tyrosyl-DNA phosphodiesterase 1 (TDP1)16
Large dataset of octocoral mitochondrial genomes provides new insights into mt-mutS evolution and function16
Significance and limitations of the use of next-generation sequencing technologies for detecting mutational signatures16
PARP1-mediated PARylation of TonEBP prevents R-loop–associated DNA damage16
Structure, function and evolution of the Helix-hairpin-Helix DNA glycosylase superfamily: Piecing together the evolutionary puzzle of DNA base damage repair mechanisms16
The role of telomeres and telomerase in the senescence of postmitotic cells16
Formation and repair of unavoidable, endogenous interstrand cross-links in cellular DNA16
Toxic R-loops: Cause or consequence of replication stress?16
Biochemical analysis of TOPBP1 oligomerization16
Function and evolution of the DNA-protein crosslink proteases Wss1 and SPRTN16
Molecular and structural characterization of disease-associated APE1 polymorphisms16
Untangling trapped topoisomerases with tyrosyl-DNA phosphodiesterases16
Pol β gap filling, DNA ligation and substrate-product channeling during base excision repair opposite oxidized 5-methylcytosine modifications15
C17orf53 is identified as a novel gene involved in inter-strand crosslink repair15
Daughter-strand gaps in DNA replication – substrates of lesion processing and initiators of distress signalling15
CST in maintaining genome stability: Beyond telomeres15
Replication initiation: Implications in genome integrity15
Molecular basis for the MacroD1-mediated hydrolysis of ADP-ribosylation15
Structural biology of DNA abasic site protection by SRAP proteins14
Helicobacter pylori severely reduces expression of DNA repair proteins PMS2 and ERCC1 in gastritis and gastric cancer14
Cancer testis antigens and genomic instability: More than immunology14
The role of DNA damage response in chemo- and radio-resistance of cancer cells: Can DDR inhibitors sole the problem?14
Understanding the DNA double-strand break repair and its therapeutic implications13
DNA damage response and breast cancer development: Possible therapeutic applications of ATR, ATM, PARP, BRCA1 inhibition13
mTOR pathway and DNA damage response: A therapeutic strategy in cancer therapy13
Compromised repair of radiation-induced DNA double-strand breaks in Fanconi anemia fibroblasts in G213
Transcription-coupled repair and the transcriptional response to UV-Irradiation13
The role of histone H3K36me3 writers, readers and erasers in maintaining genome stability13
The meiosis-specific MEIOB–SPATA22 complex cooperates with RPA to form a compacted mixed MEIOB/SPATA22/RPA/ssDNA complex13
Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes13
Olaparib enhances curcumin-mediated apoptosis in oral cancer cells by inducing PARP trapping through modulation of BER and chromatin assembly12
The dual role of DNA repair protein MGMT in cancer prevention and treatment12
Regulation of UV damage repair in quiescent yeast cells12
Nucleophosmin interaction with APE1: Insights into DNA repair regulation12
Double strand break (DSB) repair in Cyanobacteria: Understanding the process in an ancient organism12
Role of histone acetyltransferases MOF and Tip60 in genome stability12
Non-canonical function of nuclear PTEN and its implication on tumorigenesis12
Transcription-coupled DNA double-strand break repair12
New twists to the ALTernative endings at telomeres12
HOTAIR beyond repression: In protein degradation, inflammation, DNA damage response, and cell signaling12
RNA helicase, DDX3X, is actively recruited to sites of DNA damage in live cells12
Impacts of chromatin dynamics and compartmentalization on DNA repair11
DNA polymerase β outperforms DNA polymerase γ in key mitochondrial base excision repair activities11
Non-canonical interaction of DNA repair proteins with intact and cleaved AP sites11
The cross-talk between signaling pathways, noncoding RNAs and DNA damage response: Emerging players in cancer progression11
MicroRNAs and the DNA damage response: How is cell fate determined?11
Transcriptional dysregulation of base excision repair proteins in breast cancer11
Perspectives on formaldehyde dysregulation: Mitochondrial DNA damage and repair in mammalian cells11
DNA damage response and PD-1/PD-L1 pathway in ovarian cancer11
Cyclin-dependent kinase inhibitors (CDKIs) and the DNA damage response: The link between signaling pathways and cancer11
Fine-tuning of DNA base excision/strand break repair via acetylation11
Double-strand breaks: When DNA repair events accidentally meet11
DNA repair pathways as guardians of the genome: Therapeutic potential and possible prognostic role in hematologic neoplasms11
Molecular analysis directs the prognosis, management and treatment of patients with xeroderma pigmentosum10
The “adductome”: A limited repertoire of adducted proteins in human cells10
DNA mismatch repair in the chromatin context: Mechanisms and therapeutic potential10
USP13 regulates the replication stress response by deubiquitinating TopBP110
Sp1-dependent recruitment of the histone acetylase p300 to DSBs facilitates chromatin remodeling and recruitment of the NHEJ repair factor Ku7010
Alteration of genetic recombination and double-strand break repair in human cells by progerin expression10
The multifaceted roles of DNA repair and replication proteins in aging and obesity10
miR-197-5p increases Doxorubicin-mediated anticancer cytotoxicity of HT1080 fibrosarcoma cells by decreasing drug efflux10
Proficiency in homologous recombination repair is prerequisite for activation of G2-checkpoint at low radiation doses10
Chaperoning histones at the DNA repair dance10
Requirements for PARP-1 covalent crosslinking to DNA (PARP-1 DPC)10
PCNA, a focus on replication stress and the alternative lengthening of telomeres pathway9
Telomere replication—When the going gets tough9
Size-dependent antirecombinogenic effect of short spacers on palindrome recombinogenicity9
Structural determinants of nucleobase modification recognition in the AlkB family of dioxygenases9
Hydroxychloroquine induces oxidative DNA damage and mutation in mammalian cells9