OOIR: Observatory of International Research

Papers

(The TQCC of DNA Repair is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-07-01 to 2024-07-01.)

Article	Citations
Roles for 53BP1 in the repair of radiation-induced DNA double strand breaks	66
Mammalian DNA base excision repair: Dancing in the moonlight	62
The MRE11 complex: A versatile toolkit for the repair of broken DNA	61
ADP-ribosylation of DNA and RNA	61
Biomolecular condensates at sites of DNA damage: More than just a phase	56
Defining R-loop classes and their contributions to genome instability	55
Debulking of topoisomerase DNA-protein crosslinks (TOP-DPC) by the proteasome, non-proteasomal and non-proteolytic pathways	53
Recent advances in γH2AX biomarker-based genotoxicity assays: A marker of DNA damage and repair	53
Molecular origins of APOBEC-associated mutations in cancer	50
DNA mismatch repair-dependent DNA damage responses and cancer	45
Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair	40
The cerebellar degeneration in ataxia-telangiectasia: A case for genome instability	36
The recent advances in non-homologous end-joining through the lens of lymphocyte development	36
PARP1: Structural insights and pharmacological targets for inhibition	35
Towards DNA-damage induced autophagy: A Boolean model of p53-induced cell fate mechanisms	34
Towards a comprehensive view of 8-oxo-7,8-dihydro-2’-deoxyguanosine: Highlighting the intertwined roles of DNA damage and epigenetics in genomic instability	33
Strand discrimination in DNA mismatch repair	33
The role of the SWI/SNF chromatin remodelling complex in the response to DNA double strand breaks	31
How to fix DNA-protein crosslinks	31
Targeting Wee1 kinase as a therapeutic approach in Hematological Malignancies	31
Revisiting the BRCA-pathway through the lens of replication gap suppression	31
Consequences of compromised mitochondrial genome integrity	31
Role of mtDNA disturbances in the pathogenesis of Alzheimer’s and Parkinson’s disease	29
Coping with RNA damage with a focus on APE1, a BER enzyme at the crossroad between DNA damage repair and RNA processing/decay	29
TREX1 – Apex predator of cytosolic DNA metabolism	29

Human DNA ligases in replication and repair	28
The evolving complexity of DNA damage foci: RNA, condensates and chromatin in DNA double-strand break repair	28
Dealing with transcription-blocking DNA damage: Repair mechanisms, RNA polymerase II processing and human disorders	28
P53 in the impaired lungs	27
Roles for MDC1 in cancer development and treatment	27
Time for remodeling: SNF2-family DNA translocases in replication fork metabolism and human disease	27
PARPs’ impact on base excision DNA repair	27
The SNM1A DNA repair nuclease	26
NAD+-mediated regulation of mammalian base excision repair	26
Hypermutation in single-stranded DNA	25
XRCC1 – Strategies for coordinating and assembling a versatile DNA damage response	25
Signaling pathways involved in cell cycle arrest during the DNA breaks	24
DNA damage response and repair in osteosarcoma: Defects, regulation and therapeutic implications	24
Twenty years of t-loops: A case study for the importance of collaboration in molecular biology	24
EXO1: A tightly regulated nuclease	24
Cellular response to endogenous DNA damage: DNA base modifications in gene expression regulation	23
Transcription-coupled nucleotide excision repair: New insights revealed by genomic approaches	23
NTHL1 in genomic integrity, aging and cancer	23
Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1	23
The dark side of homology-directed repair	23
GTPases, genome, actin: A hidden story in DNA damage response and repair mechanisms	22
PRMT1 is critical to FEN1 expression and drug resistance in lung cancer cells	22
DNA helicases and their roles in cancer	21
Expanding molecular roles of UV-DDB: Shining light on genome stability and cancer	21
Impact of circadian disruption on health; SIRT1 and Telomeres	21
Formation and repair of unavoidable, endogenous interstrand cross-links in cellular DNA	20
Transcription coupled base excision repair in mammalian cells: So little is known and so much to uncover	20
Understanding the sequence and structural context effects in oxidative DNA damage repair	19
Pol β gap filling, DNA ligation and substrate-product channeling during base excision repair opposite oxidized 5-methylcytosine modifications	19
Toxic R-loops: Cause or consequence of replication stress?	19
PARP1-mediated PARylation of TonEBP prevents R-loop–associated DNA damage	19
Untangling trapped topoisomerases with tyrosyl-DNA phosphodiesterases	18
Mechanisms of direct replication restart at stressed replisomes	18
The dual role of DNA repair protein MGMT in cancer prevention and treatment	18
The role of histone H3K36me3 writers, readers and erasers in maintaining genome stability	18
Increased DNA repair capacity augments resistance of glioblastoma cells to photodynamic therapy	18
Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase 1 DNA-protein crosslinks and 3′-blocking lesions in the absence of tyrosyl-DNA phosphodiesterase 1 (TDP1)	18
Large dataset of octocoral mitochondrial genomes provides new insights into mt-mutS evolution and function	18
Structure, function and evolution of the Helix-hairpin-Helix DNA glycosylase superfamily: Piecing together the evolutionary puzzle of DNA base damage repair mechanisms	17
C17orf53 is identified as a novel gene involved in inter-strand crosslink repair	17
Biochemical analysis of TOPBP1 oligomerization	17
The role of DNA damage response in chemo- and radio-resistance of cancer cells: Can DDR inhibitors sole the problem?	17
Transcription-coupled DNA double-strand break repair	17
The role of telomeres and telomerase in the senescence of postmitotic cells	17
Significance and limitations of the use of next-generation sequencing technologies for detecting mutational signatures	16
CST in maintaining genome stability: Beyond telomeres	16
Replication initiation: Implications in genome integrity	16
HOTAIR beyond repression: In protein degradation, inflammation, DNA damage response, and cell signaling	16
Cancer testis antigens and genomic instability: More than immunology	16
Molecular and structural characterization of disease-associated APE1 polymorphisms	16

Daughter-strand gaps in DNA replication – substrates of lesion processing and initiators of distress signalling	15
Transcription-coupled repair and the transcriptional response to UV-Irradiation	15
Structural biology of DNA abasic site protection by SRAP proteins	15
Molecular basis for the MacroD1-mediated hydrolysis of ADP-ribosylation	15
mTOR pathway and DNA damage response: A therapeutic strategy in cancer therapy	15
Understanding the DNA double-strand break repair and its therapeutic implications	15
Role of histone acetyltransferases MOF and Tip60 in genome stability	14
Chaperoning histones at the DNA repair dance	14
Compromised repair of radiation-induced DNA double-strand breaks in Fanconi anemia fibroblasts in G2	13
DNA repair pathways as guardians of the genome: Therapeutic potential and possible prognostic role in hematologic neoplasms	13
New twists to the ALTernative endings at telomeres	13
The meiosis-specific MEIOB–SPATA22 complex cooperates with RPA to form a compacted mixed MEIOB/SPATA22/RPA/ssDNA complex	13
RNA helicase, DDX3X, is actively recruited to sites of DNA damage in live cells	13
Double strand break (DSB) repair in Cyanobacteria: Understanding the process in an ancient organism	13
DNA damage response and breast cancer development: Possible therapeutic applications of ATR, ATM, PARP, BRCA1 inhibition	13
Double-strand breaks: When DNA repair events accidentally meet	13
DNA double-strand break repair in male germ cells during spermatogenesis and its association with male infertility development	13
Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes	13
Perspectives on formaldehyde dysregulation: Mitochondrial DNA damage and repair in mammalian cells	13
Cyclin-dependent kinase inhibitors (CDKIs) and the DNA damage response: The link between signaling pathways and cancer	13
DNA damage response and PD-1/PD-L1 pathway in ovarian cancer	13
MicroRNAs and the DNA damage response: How is cell fate determined?	12
Non-canonical function of nuclear PTEN and its implication on tumorigenesis	12
Sp1-dependent recruitment of the histone acetylase p300 to DSBs facilitates chromatin remodeling and recruitment of the NHEJ repair factor Ku70	12
Impacts of chromatin dynamics and compartmentalization on DNA repair	12
Olaparib enhances curcumin-mediated apoptosis in oral cancer cells by inducing PARP trapping through modulation of BER and chromatin assembly	12
DNA polymerase β outperforms DNA polymerase γ in key mitochondrial base excision repair activities	11
PCNA, a focus on replication stress and the alternative lengthening of telomeres pathway	11
DNA mismatch repair in the chromatin context: Mechanisms and therapeutic potential	11
The multifaceted roles of DNA repair and replication proteins in aging and obesity	11
miR-197-5p increases Doxorubicin-mediated anticancer cytotoxicity of HT1080 fibrosarcoma cells by decreasing drug efflux	11
A DNA replication fork-centric view of the budding yeast DNA damage response	11
Alteration of genetic recombination and double-strand break repair in human cells by progerin expression	11
Hydroxychloroquine induces oxidative DNA damage and mutation in mammalian cells	11
Transcriptional dysregulation of base excision repair proteins in breast cancer	11
Fine-tuning of DNA base excision/strand break repair via acetylation	11
The cross-talk between signaling pathways, noncoding RNAs and DNA damage response: Emerging players in cancer progression	11
USP13 regulates the replication stress response by deubiquitinating TopBP1	11
Sequence context effects of replication of Fapy•dG in three mutational hot spot sequences of the p53 gene in human cells	10
Proficiency in homologous recombination repair is prerequisite for activation of G2-checkpoint at low radiation doses	10
Histone variants: The unsung guardians of the genome	10
DNA damage-induced sumoylation of Sp1 induces its interaction with RNF4 and degradation in S phase to remove 53BP1 from DSBs and permit HR	10
Tissue-specific reduction in MLH1 expression induces microsatellite instability in intestine of Mlh1 mice	10
G-quadruplex resolution: From molecular mechanisms to physiological relevance	10
Molecular dynamics simulations reveal how H3K56 acetylation impacts nucleosome structure to promote DNA exposure for lesion sensing	10
Molecular analysis directs the prognosis, management and treatment of patients with xeroderma pigmentosum	10
DNA damage and regulation of protein homeostasis	10
Post-translational modification of factors involved in homologous recombination	10
Telomere replication—When the going gets tough	10