DNA Repair

Article	Citations
Active genome integrity	64
Activation of Escherichia coli RecA* in recA730 lexA+ and recA730 lexA(Def) strain backgrounds	55
Regulatory apoptotic fragment of PARP1 complements catalytic fragment for PAR and DNA-dependent activity but inhibits DNA-induced catalytic stimulation of PARP2	52
DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining	44
Building an integrated view of R-loops, transcription, and chromatin	41
Contents of previous 3 special issues in this series of perspectives	40
Spatial mapping of the DNA adducts in cancer	35
Functional defects of cancer-associated MDC1 mutations in DNA damage repair	34
Suppressors of Blm-deficiency identify three novel proteins that facilitate DNA repair in Ustilago maydis	28
Editors’ note Penny Jeggo and Bennett Van Houten	27
Single-molecule approaches for DNA damage detection and repair: A focus on Repair Assisted Damage Detection (RADD)	26
Acetylation of H3K56 orchestrates UV-responsive chromatin events that generate DNA accessibility during Nucleotide Excision Repair	25
The burden of overweight: Higher body mass index, but not vital exhaustion, is associated with higher DNA damage and lower DNA repair capacity	25
Single-molecule imaging of genome maintenance proteins encountering specific DNA sequences and structures	23
Harnessing R-loop dynamics: Challenging cancer therapy resistance	22
The role of human PrimPol active site residue Gln48 in catalysis and complex formation with DNA	21
Stressed? Break-induced replication comes to the rescue!	21
From cooperation to conflicts – A complicated relationship between transcription and replication	21
A novel Family V uracil DNA glycosylase from Sulfolobus islandicus REY15A	20
Irc20 modulates LOH frequency and distribution in S. cerevisiae	20
Corruption of DNA end-joining in mammalian chromosomes by progerin expression	19
PARP1-PROTACs providing novel opportunities in precision oncology by targeting DNA damage response	19
Targeting base excision repair in precision oncology	18
Editorial Board	18
Positioning loss of PARP1 activity as the central toxic event in BRCA-deficient cancer	18

Editorial Board	18
Chromatin meets the cytoskeleton: the importance of nuclear actin dynamics and associated motors for genome stability	18
Comparing Mfd- and UvrD-dependent models of transcription coupled DNA repair in live Escherichia coli using single-molecule tracking	17
What are the DNA lesions underlying formaldehyde toxicity?	17
The B cell dilemma: Diversity or fidelity?	17
DNA damage response and genomic instability disorder: Meeting report of the 20th Ataxia-Telangiectasia Workshop (ATW-2024) in conjunction with the 15th international symposium on DNA damage response &	17
DNA repair-related heritable photosensitivity syndromes: Mutation landscape in a multiethnic cohort of 17 multigenerational families with high degree of consanguinity	16
DNA synthesis across DNA hairpins by human PrimPol	16
Phospho-SIM and exon8b of PML protein regulate formation of doxorubicin-induced rDNA-PML compartment	16
PARP inhibitors in ovarian cancer: Mechanisms of resistance and implications to therapy	16
The differential roles of rad9 alternatively spliced forms in double- strand DNA break repair during Drosophila meiosis	16
Protein-protein interactions in the core nucleotide excision repair pathway	15
The role of SLFN11 in DNA replication stress response and its implications for the Fanconi anemia pathway	15
Metazoan nuclear pore complexes in gene regulation and genome stability	15
Double-strand break repair and mis-repair in 3D	15
Editorial Board	15
The interferon response at the intersection of genome integrity and innate immunity	15
Centromere: A Trojan horse for genome stability	14
Editorial Board	14
Long-range PCR as a tool for evaluating mitochondrial DNA damage: Principles, benefits, and limitations of the technique	14
Camptothecin compromises transcription recovery and cell survival against cisplatin and ultraviolet irradiation regardless of transcription-coupled nucleotide excision repair	13
One-ended and two-ended breaks at nickase-broken replication forks	13
Expression of BRCA1, BRCA2, RAD51, and other DSB repair factors is regulated by CRL4WDR70	13
Endogenous base damage as a driver of genomic instability in homologous recombination-deficient cancers	13
Using the safety scissors: DNA resection regulation at DNA double-strand breaks and telomeres	12
NBS1 binds directly to TOPBP1 via disparate interactions between the NBS1 BRCT1 domain and the TOPBP1 BRCT1 and BRCT2 domains	12
Richard Gatti: From concert pianist to bone marrow transplants and the DNA damage response syndrome, ataxia-telangiectasia	12
Variation in G-quadruplex sequence and topology differentially impacts human DNA polymerase fidelity	12
Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory	12
Impairment of the non-catalytic subunit Dpb2 of DNA Pol ɛ results in increased involvement of Pol δ on the leading strand	12
The multifaceted roles of the Ctf4 replisome hub in the maintenance of genome integrity	12
Chromosomal single-strand break repair and neurological disease: Implications on transcription and emerging genomic tools	12
Yearly perspective from the Co-Editors in Chief	11
miR-185–5p rewires cisplatin resistance by restoring miR-203a-3p expression via downregulation of SOX9	11
Biochemical characterization and mutational analysis of a mismatch glycosylase from the hyperthermophilic euryarchaeon Thermococcus barophilus Ch5	11
Inhibition of human DNA alkylation damage repair enzyme ALKBH2 by HIV protease inhibitor ritonavir	11
Somatic mutation patterns at Ig and Non-Ig Loci	11
Cutting Edge Perspectives in genome maintenance X	11
Reversible association of ubiquitin with PCNA is important for template switching in S. cerevisiae	10
Mechanisms and regulation of replication fork reversal	10
Presenilin-1, mutated in familial Alzheimer’s disease, maintains genome stability via a γ-secretase dependent way	10
Altered pathways in Cockayne syndrome: Involvement of MAPK, PI3K-Akt, extracellular matrix, inflammation, and neuronal signaling	10
Weaponizing CRISPR/Cas9 for selective elimination of cells with an aberrant genome	10
RNF4 prevents genomic instability caused by chronic DNA under-replication	10
How DNA secondary structures drive replication fork instability	10
C-terminal residues of DNA polymerase β and E3 ligase required for ubiquitin-linked proteolysis of oxidative DNA-protein crosslinks	10
Corrigendum to “Role of NEIL1 in genome maintenance” [DNA Repair 148 (2025) 103820]	10
BRCA1 and BRCA2 in DNA damage and replication stress response: Insights into their functions, mechanisms, and implications for cancer treatment	10
Small-molecule activator of SMUG1 enhances repair of pyrimidine lesions in DNA	10
A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein	10

Altered lipid profile in mice lacking the DNA repair protein ERCC1	10
Frailty, sex, and poverty are associated with DNA damage and repair in frail, middle-aged urban adults	10
Contents of previous 3 special issues in this series of perspectives	9
Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhances alkylating agent and PARG inhibition induced cytotoxicity	9
Obituary	9
Mlh1 interacts with both Msh2 and Msh6 for recruitment during mismatch repair	9
DNA Repair Special Issue: Genome maintenance pathways in cancer - etiology, biomarkers and targets	9
Insight into meiotic DNA end resection: Mechanisms and regulation	9
KBM-mediated interactions with KU80 promote cellular resistance to DNA replication stress in CHO cells	9
Regulation of DNA damage-induced HLA class I presentation	9
TFIIH central activity in nucleotide excision repair to prevent disease	9
Editorial Board	9
The flap endonuclease-1 mediated maturation of Okazaki fragments is critical for the cellular tolerance to remdesivir	9
Remdesivir triphosphate is a valid substrate to initiate synthesis of DNA primers by human PrimPol	9
Probing the structure and function of polymerase θ helicase-like domain	9
Editorial Board	9
A special issue: DNA damage response in disease and therapy	8
Therapeutic targeting of mismatch repair proteins in triplet repeat expansion diseases	8
Screening of glycosylase activity on oxidative derivatives of methylcytosine: Pedobacter heparinus SMUG2 as a formylcytosine- and carboxylcytosine-DNA glycosylase	8
Biochemical characterization and mutational studies of endonuclease Q from the hyperthermophilic euryarchaeon Thermococcus gammatolerans	8
Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates	8
USP1 in regulation of DNA repair pathways	8
Cutting edge perspectives in genome maintenance XI	8
SMC-5/6 complex subunit NSE-1 plays a crucial role in meiosis and DNA repair in Caenorhabditis elegans	8
Discovery of KPT-6566 as STAG1/2 Inhibitor sensitizing PARP and NHEJ Inhibitors to suppress tumor cells growth in vitro	8
Tribute to life and science of Grigory (Gosha) Dianov	8
Low and high doses of ionizing radiation evoke discrete global (phospho)proteome responses	8
Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication	8
The replication stress response: Mechanisms and functions	8
DNA lesions that block transcription induce the death of Trypanosoma cruzi via ATR activation, which is dependent on the presence of R-loops	8
Genome integrity and inflammation in the nervous system	8
Variants in the first methionine of RAD51C are homologous recombination proficient due to an alternative start site	8
Structure and mechanism in non-homologous end joining	7
The roles of non-productive complexes of DNA repair proteins with DNA lesions	7
From rest to repair: Safeguarding genomic integrity in quiescent cells	7
Editorial Board	7
Real-time single-molecule visualization using DNA curtains reveals the molecular mechanisms underlying DNA repair pathways	7
Compartmentalization of the DNA damage response: Mechanisms and functions	7
Why the ROS matters: One-electron oxidants focus DNA damage and repair on G-quadruplexes for gene regulation	7
LncRNA LINC01664 promotes cancer resistance through facilitating homologous recombination-mediated DNA repair	7
Replication initiation sites and zones in the mammalian genome: Where are they located and how are they defined?	7
The biochemistry of the carcinogenic alcohol metabolite acetaldehyde	7
DNA damage repair (DDR) related prognostic risk model in multiple myeloma based on single-cell and bulk sequencing	7
The role of histone H3K36me3 writers, readers and erasers in maintaining genome stability	7
PARPs and ADP-ribosyl hydrolases in cancer therapy: From drug targets to biomarkers	7
Emerging connections: Poly(ADP-ribose), FET proteins and RNA in the regulation of DNA damage condensates	7
Deletions initiated by the vaccinia virus TopIB protein in yeast	7
Editorial Board	7
Reversal of histone H2B mono-ubiquitination is required for replication stress recovery	7
Temporal and spatial dynamics of DNA double-strand break repair centers	7
Structure, function and evolution of the HerA subfamily proteins	7
DONSON: Slding in 2 the limelight	7
Errol Friedberg: A life in writing	7
Phylogenetic distribution, structural analysis and interaction of nucleotide excision repair proteins in cyanobacteria	7
The fast-growing business of Serine ADP-ribosylation	6
S-palmitoylation: An oily modification guardinggenome stability	6
Multiple functions of PARP1 in the repair of DNA double strand breaks	6
C. elegans ribosomal protein S3 protects against H2O2-induced DNA damage and suppresses spontaneous mutations in yeast	6
A-T neurodegeneration and DNA damage-induced transcriptional stress	6
Repair of genomic interstrand crosslinks	6
APE1 is a master regulator of the ATR-/ATM-mediated DNA damage response	6
FBH1 and the replication stress response: Implications for genome stability and cancer development	6
The nucleotide excision repair proteins through the lens of molecular dynamics simulations	6
Cockayne syndrome group B protein uses its DNA translocase activity to promote mitotic DNA synthesis	6
Interaction of mitoxantrone with abasic sites - DNA strand cleavage and inhibition of apurinic/apyrimidinic endonuclease 1, APE1	6
Live cell single-molecule imaging to study DNA repair in human cells	6
Holding it together: DNA end synapsis during non-homologous end joining	6
Editorial Board	6
DNA polymerase δ: A single Pol31 polymorphism suppresses the strain background-specific lethality of Pol32 inactivation in Saccharomyces cerevisiae	6
Determinants governing BRC function evaluated by mutational analysis of Brh2 in Ustilago maydis	6
DNA repair pathways in the mitochondria	5
Multifunctional properties of Nej1XLF C-terminus promote end-joining and impact DNA double-strand break repair pathway choice	5
Joining of DNA breaks- interplay between DNA ligases and poly (ADP-ribose) polymerases	5
Modulation of OGG1 enzymatic activity by the cellular machinery – have all the boxes been ticked?	5
Monitoring DNA polymerase β mitochondrial localization and dynamics	5
UVSSA facilitates transcription-coupled repair of DNA interstrand crosslinks	5
DNA G-quadruplexes: Structural and functional insights	5
Targeting DNA damage sensors for cancer therapy	5
Phosphoregulation of the checkpoint kinase Mec1ATR	5
Global screening of base excision repair in nucleosome core particles	5

To divide or not to divide? NAC8 (SOG1) as a key regulator of DNA damage response in barley (Hordeum vulgare L.)	5
BCLAF1, a functional partner of BACH1, participates in DNA damage response	5
The analysis of protein recruitment to laser microirradiation-induced DNA damage in live cells: Best practices for data analysis	5
Kinome-wide screening uncovers a role for Bromodomain Protein 3 in DNA double-stranded break repair	5
The C-terminal tail of Rad17, iVERGE, binds the 9‒1‒1 complex independently of AAA+ ATPase domains to provide another clamp–loader interface	5
Bulk synthesis and beyond: The roles of eukaryotic replicative DNA polymerases	5
The Ataxia-telangiectasia mutated (ATM) is the most important gene for repairing the DNA in Myelodysplastic Neoplasm	5
Live cell transcription-coupled nucleotide excision repair dynamics revisited	5
Functions of PMS2 and MLH1 important for regulation of divergent repeat-mediated deletions	5
Editorial Board	5
Partial deletions of the autoregulatory C-terminal domain of Artemis and their effect on its nuclease activity	5
Compared to other NHEJ factors, DNA-PK protein and RNA levels are markedly increased in all higher primates, but not in prosimians or other mammals	5
Checkpoint activation and recovery: regulation of the 9–1–1 axis by the PP2A phosphatase	4
Contributions of DNA double strand break repair pathways to DNA crosslink repair	4
Clinical evidence for a role of E2F1-induced replication stress in modulating tumor mutational burden and immune microenvironment	4
A tale of two mechanisms: Clarification of the pathway for MBD4 catalyzed glycosidic bond cleavage using MD and QM/MM calculations	4
The C-terminal domain of Arabidopsis ROS1 DNA demethylase interacts with histone H3 and is required for DNA binding and catalytic activity	4
Temporal recruitment of base excision DNA repair factors in living cells in response to different micro-irradiation DNA damage protocols	4
SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice	4
O-GlcNAc transferase is important for homology-directed repair	4
Single-molecule toxicogenomics: Optical genome mapping of DNA-damage in nanochannel arrays	4
FAM21 interacts with Ku to promote the localization of WASH to DNA double strand break sites	4
Spatio-temporal dynamics of the DNA glycosylase OGG1 in finding and processing 8-oxoguanine	4
Rrp1, Rrp2 and Uls1 – Yeast SWI2/SNF2 DNA dependent translocases in genome stability maintenance	4
How to write an ending: Telomere replication as a multistep process	4
A bibliometric analysis of research on R-loop: Landscapes, highlights and trending topics	4
Recent advances in understanding the molecular mechanisms of SLX4 recruitment in the replication stress response	4
Evolution of the triplet BRCT domain	4
The DNA damage induced immune response: Implications for cancer therapy	4
Mediator complex in transcription regulation and DNA repair: Relevance for human diseases	4
Biochemical analysis of H2O2-induced mutation spectra revealed that multiple damages were involved in the mutational process	4
53BP1-the ‘Pandora’s box’ of genome integrity	4
Overexpression of the WWE domain of RNF146 modulates poly-(ADP)-ribose dynamics at sites of DNA damage	4
FBH1 deficiency sensitizes cells to WEE1 inhibition by promoting mitotic catastrophe	4
Saccharomyces cerevisiae apurinic/apyrimidinic endonuclease 1 repairs abasic site-mediated DNA-peptide/protein cross-links	4
Spontaneous and salt stress-induced molecular instability in the progeny of MSH7 deficient Arabidopsis thaliana plants	4
Editorial	4
Polymerase theta: Genome protection through regulated deployment	4
UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1	4
Lawrence H. Thompson: A life of bikes, birds, and DNA repair (1941–2024)	4
Genomic stress and impaired DNA repair in Alzheimer disease	4
‘From R-lupus to cancer’: Reviewing the role of R-loops in innate immune responses	4
Microglial inflammation in genome instability: A neurodegenerative perspective	4
Unveiling cGAS mechanisms: Insights into DNA damage and immune sensing in cancer	4
DNA topoisomerase IIß inhibition blocks DNA end resection and synergizes with PARPi in BRCA1-deficient models	4
The model moss Physcomitrium patens relies heavily on homologous recombination to repair DNA double-strand breaks	3
NEIL3 promotes cell proliferation of ccRCC via the cyclin D1-Rb-E2F1 feedback loop regulation	3
Role of the nucleotide excision repair pathway proteins (UvrB and UvrD2) in recycling UdgB, a base excision repair enzyme in Mycobacterium smegmatis	3
The DHX9 helicase interacts with human DNA polymerase δ4 and stimulates its activity in D-loop extension synthesis	3
Divergent structures of Mammalian and gammaherpesvirus uracil DNA glycosylases confer distinct DNA binding and substrate activity	3
The interactions between DNA methylation machinery and long non-coding RNAs in tumor progression and drug resistance	3
Editors’ note on “p21CDKN1A participates in base excision repair by regulating the activity of poly(ADP-ribose) polymerase-1”	3
Synergistic effects on mutagenicity of tandem lesions containing 8-oxo-7,8-dihydro-2′-deoxyguanosine or Fapy•dG flanked by a 3′ 5-formyl-2′-deoxyuridine in human cells	3
Editorial Board	3
Role of HSP40 proteins in genome maintenance, insulin signaling and cancer therapy	3
Genome organization and stability in mammalian pre-implantation development	3
Editorial Board	3
DNA damage response inhibitors in cancer therapy: Mechanisms, clinical development, and combination strategies	3
How RNA impacts DNA repair	3
Super-resolution GSDIM microscopy unveils distinct nanoscale characteristics of DNA repair foci under diverse genotoxic stress	3
Polymorphic variant Asp239Tyr of human DNA glycosylase NTHL1 is inactive for removal of a variety of oxidatively-induced DNA base lesions from genomic DNA	3
Mechanisms of tandem duplication in the cancer genome	3
UBE2C promotes cell cycle progression and suppresses DNA damage-induced apoptosis in triple-negative breast cancer	3
Exploring factors influencing choice of DNA double-strand break repair pathways	3
Helicase activities of Rad5 and Rrm3 genetically interact in the prevention of recombinogenic DNA lesions in Saccharomyces cerevisiae	3
Editorial Board	3
The effect of methylation and hydroxymethylation of cytosine on activity and fidelity of Pol λ and Pol β	3
Initiation of base excision repair is modulated by nucleosome occupancy modifying sequences	3
A redox-sensitive iron-sulfur cluster in murine FAM72A controls its ability to degrade the nuclear form of uracil-DNA glycosylase	3
The HPF1-dependent histone PARylation catalyzed by PARP2 is specifically stimulated by an incised AP site-containing BER DNA intermediate	3
Differential ETS1 binding to T:G mismatches within a CpG dinucleotide contributes to C-to-T somatic mutation rate of the IDH2 hotspot at codon Arg140	3
Imaging the cellular response to an antigen tagged interstrand crosslinking agent	3
Multi-scale cellular imaging of DNA double strand break repair	3
Development and characterization of a novel NEIL1 nanobody	3
DNA repair deficiencies and neurodegeneration	3
Transcription reprogramming and endogenous DNA damage	3
Methylation and hydroxymethylation of cytosine alter activity and fidelity of translesion DNA polymerases	3
The role of DNA repair deficiency in lipid accumulation: A proof-of-concept study	3
The HNH endonuclease domain of the giant virus MutS7 specifically binds to branched DNA structures with single-stranded regions	3