DNA Repair

Article	Citations
ADP-ribosylation of DNA and RNA	65
Defining R-loop classes and their contributions to genome instability	63
Biomolecular condensates at sites of DNA damage: More than just a phase	62
Recent advances in γH2AX biomarker-based genotoxicity assays: A marker of DNA damage and repair	59
Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair	42
PARP1: Structural insights and pharmacological targets for inhibition	39
Towards DNA-damage induced autophagy: A Boolean model of p53-induced cell fate mechanisms	38
Revisiting the BRCA-pathway through the lens of replication gap suppression	37
The cerebellar degeneration in ataxia-telangiectasia: A case for genome instability	36
Towards a comprehensive view of 8-oxo-7,8-dihydro-2’-deoxyguanosine: Highlighting the intertwined roles of DNA damage and epigenetics in genomic instability	36
Strand discrimination in DNA mismatch repair	34
Targeting Wee1 kinase as a therapeutic approach in Hematological Malignancies	33
Dealing with transcription-blocking DNA damage: Repair mechanisms, RNA polymerase II processing and human disorders	33
Coping with RNA damage with a focus on APE1, a BER enzyme at the crossroad between DNA damage repair and RNA processing/decay	31
P53 in the impaired lungs	29
Time for remodeling: SNF2-family DNA translocases in replication fork metabolism and human disease	29
The evolving complexity of DNA damage foci: RNA, condensates and chromatin in DNA double-strand break repair	28
Roles for MDC1 in cancer development and treatment	28
The dark side of homology-directed repair	28
The SNM1A DNA repair nuclease	27
DNA damage response and repair in osteosarcoma: Defects, regulation and therapeutic implications	26
Transcription-coupled nucleotide excision repair: New insights revealed by genomic approaches	25
Signaling pathways involved in cell cycle arrest during the DNA breaks	25
Transcription coupled base excision repair in mammalian cells: So little is known and so much to uncover	24
GTPases, genome, actin: A hidden story in DNA damage response and repair mechanisms	24

PRMT1 is critical to FEN1 expression and drug resistance in lung cancer cells	23
CST in maintaining genome stability: Beyond telomeres	23
Cellular response to endogenous DNA damage: DNA base modifications in gene expression regulation	23
Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1	23
The dual role of DNA repair protein MGMT in cancer prevention and treatment	23
DNA helicases and their roles in cancer	23
Impact of circadian disruption on health; SIRT1 and Telomeres	22
Mechanisms of direct replication restart at stressed replisomes	22
The role of histone H3K36me3 writers, readers and erasers in maintaining genome stability	22
Toxic R-loops: Cause or consequence of replication stress?	21
Transcription-coupled DNA double-strand break repair	21
Formation and repair of unavoidable, endogenous interstrand cross-links in cellular DNA	21
Cancer testis antigens and genomic instability: More than immunology	20
Large dataset of octocoral mitochondrial genomes provides new insights into mt-mutS evolution and function	20
Significance and limitations of the use of next-generation sequencing technologies for detecting mutational signatures	20
The role of telomeres and telomerase in the senescence of postmitotic cells	19
Increased DNA repair capacity augments resistance of glioblastoma cells to photodynamic therapy	19
Pol β gap filling, DNA ligation and substrate-product channeling during base excision repair opposite oxidized 5-methylcytosine modifications	19
PARP1-mediated PARylation of TonEBP prevents R-loop–associated DNA damage	19
mTOR pathway and DNA damage response: A therapeutic strategy in cancer therapy	18
Chaperoning histones at the DNA repair dance	18
Biochemical analysis of TOPBP1 oligomerization	18
HOTAIR beyond repression: In protein degradation, inflammation, DNA damage response, and cell signaling	18
C17orf53 is identified as a novel gene involved in inter-strand crosslink repair	18
Replication initiation: Implications in genome integrity	17
RNA helicase, DDX3X, is actively recruited to sites of DNA damage in live cells	17
Structure, function and evolution of the Helix-hairpin-Helix DNA glycosylase superfamily: Piecing together the evolutionary puzzle of DNA base damage repair mechanisms	17
The role of DNA damage response in chemo- and radio-resistance of cancer cells: Can DDR inhibitors sole the problem?	17
Transcription-coupled repair and the transcriptional response to UV-Irradiation	16
Daughter-strand gaps in DNA replication – substrates of lesion processing and initiators of distress signalling	16
Cyclin-dependent kinase inhibitors (CDKIs) and the DNA damage response: The link between signaling pathways and cancer	16
DNA double-strand break repair in male germ cells during spermatogenesis and its association with male infertility development	16
New twists to the ALTernative endings at telomeres	15
DNA damage response and PD-1/PD-L1 pathway in ovarian cancer	15
The meiosis-specific MEIOB–SPATA22 complex cooperates with RPA to form a compacted mixed MEIOB/SPATA22/RPA/ssDNA complex	15
Role of histone acetyltransferases MOF and Tip60 in genome stability	15
Double-strand breaks: When DNA repair events accidentally meet	15
Understanding the DNA double-strand break repair and its therapeutic implications	15
Non-canonical function of nuclear PTEN and its implication on tumorigenesis	14
Impacts of chromatin dynamics and compartmentalization on DNA repair	14
Compromised repair of radiation-induced DNA double-strand breaks in Fanconi anemia fibroblasts in G2	14
The cross-talk between signaling pathways, noncoding RNAs and DNA damage response: Emerging players in cancer progression	14
UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1	14
Perspectives on formaldehyde dysregulation: Mitochondrial DNA damage and repair in mammalian cells	14
Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes	14
A DNA replication fork-centric view of the budding yeast DNA damage response	14
Sp1-dependent recruitment of the histone acetylase p300 to DSBs facilitates chromatin remodeling and recruitment of the NHEJ repair factor Ku70	13
Hydroxychloroquine induces oxidative DNA damage and mutation in mammalian cells	13
DNA damage response and breast cancer development: Possible therapeutic applications of ATR, ATM, PARP, BRCA1 inhibition	13
miR-197-5p increases Doxorubicin-mediated anticancer cytotoxicity of HT1080 fibrosarcoma cells by decreasing drug efflux	13

DNA repair pathways as guardians of the genome: Therapeutic potential and possible prognostic role in hematologic neoplasms	13
Olaparib enhances curcumin-mediated apoptosis in oral cancer cells by inducing PARP trapping through modulation of BER and chromatin assembly	13
Double strand break (DSB) repair in Cyanobacteria: Understanding the process in an ancient organism	13
The multifaceted roles of DNA repair and replication proteins in aging and obesity	13
DNA damage and regulation of protein homeostasis	12
Histone variants: The unsung guardians of the genome	12
DNA polymerase β outperforms DNA polymerase γ in key mitochondrial base excision repair activities	12
MicroRNAs and the DNA damage response: How is cell fate determined?	12
New insights into the DNA repair pathway choice with NuA4/TIP60	12
Alteration of genetic recombination and double-strand break repair in human cells by progerin expression	12
PCNA, a focus on replication stress and the alternative lengthening of telomeres pathway	11
USP13 regulates the replication stress response by deubiquitinating TopBP1	11
Paradoxical role of the major DNA repair protein, OGG1, in action-at-a-distance mutation induction by 8-oxo-7,8-dihydroguanine	11
Sequence context effects of replication of Fapy•dG in three mutational hot spot sequences of the p53 gene in human cells	11
G-quadruplex resolution: From molecular mechanisms to physiological relevance	11
NELF complex fosters BRCA1 and RAD51 recruitment to DNA damage sites and modulates sensitivity to PARP inhibition	11
DNA damage-induced sumoylation of Sp1 induces its interaction with RNF4 and degradation in S phase to remove 53BP1 from DSBs and permit HR	11
Proficiency in homologous recombination repair is prerequisite for activation of G2-checkpoint at low radiation doses	11
Modulation of immune responses by DNA damage signaling	11
Molecular dynamics simulations reveal how H3K56 acetylation impacts nucleosome structure to promote DNA exposure for lesion sensing	11
Genome maintenance during embryogenesis	10
Structural determinants of nucleobase modification recognition in the AlkB family of dioxygenases	10
Timely upstream events regulating nucleotide excision repair by ubiquitin-proteasome system: ubiquitin guides the way	10
Repair of DNA double-strand breaks in RNAPI- and RNAPII-transcribed loci	10
Post-translational modification of factors involved in homologous recombination	10
The FAcilitates Chromatin Transcription (FACT) complex: Its roles in DNA repair and implications for cancer therapy	10
Tissue-specific reduction in MLH1 expression induces microsatellite instability in intestine of Mlh1 mice	10
Analysis of mutational signatures in C. elegans: Implications for cancer genome analysis	10
Histone and Chromatin Dynamics Facilitating DNA repair	10
The RNF8 and RNF168 Ubiquitin Ligases Regulate Pro- and Anti-Resection Activities at Broken DNA Ends During Non-Homologous End Joining	9
Structure and mechanism in non-homologous end joining	9
To indel or not to indel: Factors influencing mutagenesis during chromosomal break end joining	9
Multi-omic analysis of altered transcriptome and epigenetic signatures in the UV-induced DNA damage response	9
Compartmentalization of the DNA damage response: Mechanisms and functions	9
Shining light on single-strand lesions caused by the chemotherapy drug bleomycin	9
The interactions between DNA methylation machinery and long non-coding RNAs in tumor progression and drug resistance	9
The DNA ligands Arg47 and Arg76 are crucial for catalysis by human PrimPol	9
The multifaceted functions of homologous recombination in dealing with replication-associated DNA damages	9
Mechanisms of genome stability maintenance during cell division	9
Pan-cancer antagonistic inhibition pattern of ATM-driven G2/M checkpoint pathway vs other DNA repair pathways	8
Mechanisms of SSBP1 variants in mitochondrial disease: Molecular dynamics simulations reveal stable tetramers with altered DNA binding surfaces	8
Alternative complexes formed by the Escherichia coli clamp loader accessory protein HolC (x) with replication protein HolD (ψ) and repair protein YoaA	8
O-GlcNAc transferase is important for homology-directed repair	8
The burden of overweight: Higher body mass index, but not vital exhaustion, is associated with higher DNA damage and lower DNA repair capacity	8
Histone lysine modifying enzymes and their critical roles in DNA double-strand break repair	8
Histone variants H3.3 and H2A.Z/H3.3 facilitate excision of uracil from nucleosome core particles	8
Three targets in one complex: A molecular perspective of TFIIH in cancer therapy	8
Genome integrity and inflammation in the nervous system	8
The mRNA tether model for activation-induced deaminase and its relevance for Ig somatic hypermutation and class switch recombination	8
An open-source platform to quantify subnuclear foci and protein colocalization in response to replication stress	8
CometChip enables parallel analysis of multiple DNA repair activities	8
Insights into the Direct Oxidative Repair of Etheno Lesions: MD and QM/MM Study on the Substrate Scope of ALKBH2 and AlkB	8
DNA-protein crosslinks are repaired via homologous recombination in mammalian mitochondria	8
The fast-growing business of Serine ADP-ribosylation	8
Variation in G-quadruplex sequence and topology differentially impacts human DNA polymerase fidelity	8
RNA in DNA repair	8
Ubiquitylation in DNA double-strand break repair	8
The N-terminal domain of uracil-DNA glycosylase: Roles for disordered regions	8
Impact of DNA sequences on DNA ‘opening’ by the Rad4/XPC nucleotide excision repair complex	8
A novel DDB2 mutation causes defective recognition of UV-induced DNA damages and prevalent equine squamous cell carcinoma	8
Replication dependent and independent mechanisms of GAA repeat instability	7
The Sm core components of small nuclear ribonucleoproteins promote homologous recombination repair	7
Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication	7
A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein	7
Effects of radiotherapy and short-term starvation combination on metastatic and non-tumor cell lines	7
Unpaved roads: How the DNA damage response navigates endogenous genotoxins	7
Chromatin meets the cytoskeleton: the importance of nuclear actin dynamics and associated motors for genome stability	7
The DNA damage induced immune response: Implications for cancer therapy	7
Impaired DNA repair in mouse monocytes compared to macrophages and precursors	7
Live cell single-molecule imaging to study DNA repair in human cells	7
2-hexyl-4-pentynoic acid, a potential therapeutic for breast carcinoma by influencing RPA2 hyperphosphorylation-mediated DNA repair	7
Kinetics model of DNA double-strand break repair in eukaryotes	7
TOPBP1 regulates resistance of gastric cancer to oxaliplatin by promoting transcription of PARP1	6
Biochemical characterization and mutational studies of a novel 3-methlyadenine DNA glycosylase II from the hyperthermophilic Thermococcus gammatolerans	6
CTF18-RFC contributes to cellular tolerance against chain-terminating nucleoside analogs (CTNAs) in cooperation with proofreading exonuclease activity of DNA polymerase ε	6
Low and high doses of ionizing radiation evoke discrete global (phospho)proteome responses	6
DNA repair gene polymorphisms and chromosomal aberrations in healthy, nonsmoking population	6
Mitochondrial apurinic/apyrimidinic endonuclease Apn1 is not critical for the completion of the Plasmodium berghei life cycle	6
How DNA damage and non-canonical nucleotides alter the telomerase catalytic cycle	6
Post-translational regulation of Tyrosyl-DNA phosphodiesterase (TDP1 and TDP2) for the repair of the trapped topoisomerase-DNA covalent complex	6

Tyrosyl-DNA phosphodiesterase 1 excises the 3′-DNA-ALKBH1 cross-link and its application for 3′-DNA-ALKBH1 cross-link characterization by LC-MS/MS	6
Fully automated counting of DNA damage foci in tumor cell culture: A matter of cell separation	6
Role of the multifunctional transcription factor TFII-I in DNA damage repair	6
Novel insights into bulky DNA damage formation and nucleotide excision repair from high-resolution genomics	6
Cockayne syndrome group B protein uses its DNA translocase activity to promote mitotic DNA synthesis	6
Modifications and interactions at the R-loop	6
XRCC3 loss leads to midgestational embryonic lethality in mice	6
Chromatin dynamics and DNA replication roadblocks	6
TFIIH central activity in nucleotide excision repair to prevent disease	6
Plasmodium Ape1 is a multifunctional enzyme in mitochondrial base excision repair and is required for efficient transition from liver to blood stage infection	6
Mechanism for R-loop formation remote from the transcription start site: Topological issues and possible facilitation by dissociation of RNA polymerase	6
The rate of formation and stability of abasic site interstrand crosslinks in the DNA duplex	5
The DNA damage-sensing NER repair factor XPC-RAD23B does not recognize bulky DNA lesions with a missing nucleotide opposite the lesion	5
hMTH1 and GPX1 expression in human thyroid tissue is interrelated to prevent oxidative DNA damage	5
BCL-3 loss sensitises colorectal cancer cells to DNA damage by targeting homologous recombination	5
Nanoscale insight into chromatin remodeling and DNA repair complex in HeLa cells after ionizing radiation	5
Structural insights into an MsmUdgX mutant capable of both crosslinking and uracil excision capability	5
Hydrogen peroxide and Helicobacter pylori extract treatment combined with APE1 knockdown induce DNA damage, G2/M arrest and cell death in gastric cancer cell line	5
The mutational impact of Illudin S on human cells	5
Multifunctional properties of Nej1XLF C-terminus promote end-joining and impact DNA double-strand break repair pathway choice	5
Mlh1 interacts with both Msh2 and Msh6 for recruitment during mismatch repair	5
Treatment of human cells with 5-aza-dC induces formation of PARP1-DNA covalent adducts at genomic regions targeted by DNMT1	5
Spatio-temporal dynamics of the DNA glycosylase OGG1 in finding and processing 8-oxoguanine	5
Polβ/XRCC1 heterodimerization dictates DNA damage recognition and basal Polβ protein levels without interfering with mouse viability or fertility	5
dCas9 binding inhibits the initiation of base excision repair in vitro	5
Centromere: A Trojan horse for genome stability	5
Error-prone bypass patch by a low-fidelity variant of DNA polymerase zeta in human cells	5
Set1-dependent H3K4 methylation becomes critical for limiting DNA damage in response to changes in S-phase dynamics in Saccharomyces cerevisiae	5
Genomic stress and impaired DNA repair in Alzheimer disease	5
Phospho-SIM and exon8b of PML protein regulate formation of doxorubicin-induced rDNA-PML compartment	5
Increased contribution of DNA polymerase delta to the leading strand replication in yeast with an impaired CMG helicase complex	5
Corruption of DNA end-joining in mammalian chromosomes by progerin expression	5
Heterogeneity of DNA damage incidence and repair in different chromatin contexts	5
Real-time investigation of the roles of ATP hydrolysis by UvrA and UvrB during DNA damage recognition in nucleotide excision repair	5
Obstacles and opportunities for base excision repair in chromatin	5
DNA damage response and repair in pancreatic cancer development and therapy	5
Double-strand break repair and mis-repair in 3D	5
DNA glycosylases for 8-oxoguanine repair in Staphylococcus aureus	5
Chk1 inhibition induces a DNA damage bystander effect in cocultured tumour cells	5
DEF1: Much more than an RNA polymerase degradation factor	5
What are the DNA lesions underlying formaldehyde toxicity?	4
Effect of mismatch repair on the mutational footprint of the bacterial SOS mutator activity	4
Polymorphic variant Asp239Tyr of human DNA glycosylase NTHL1 is inactive for removal of a variety of oxidatively-induced DNA base lesions from genomic DNA	4
Roles of phosphatases in eukaryotic DNA replication initiation control	4
The ataxia-telangiectasia mutated gene product regulates the cellular acid-labile sulfide fraction	4
Synergistic effects on mutagenicity of tandem lesions containing 8-oxo-7,8-dihydro-2′-deoxyguanosine or Fapy•dG flanked by a 3′ 5-formyl-2′-deoxyuridine in human cells	4
Holding it together: DNA end synapsis during non-homologous end joining	4
Open gaps in the evolution of the eukaryotic nucleotide excision repair	4
Expression of BRCA1, BRCA2, RAD51, and other DSB repair factors is regulated by CRL4WDR70	4
RETRACTED: Thymoquinone sensitizes human hepatocarcinoma cells to TRAIL-induced apoptosis via oxidative DNA damage	4
The C-terminal domain of Arabidopsis ROS1 DNA demethylase interacts with histone H3 and is required for DNA binding and catalytic activity	4
Recognition and removal of clustered DNA lesions via nucleotide excision repair	4
Incorporation of 5’,8-cyclo-2’deoxyadenosines by DNA repair polymerases via base excision repair	4
The HPF1-dependent histone PARylation catalyzed by PARP2 is specifically stimulated by an incised AP site-containing BER DNA intermediate	4
Collaborations between chromatin and nuclear architecture to optimize DNA repair fidelity	4
Spatial mapping of the DNA adducts in cancer	4
Rrp1, Rrp2 and Uls1 – Yeast SWI2/SNF2 DNA dependent translocases in genome stability maintenance	4
Telomeres as hotspots for innate immunity and inflammation	4
Single-molecule studies of helicases and translocases in prokaryotic genome-maintenance pathways	4
Phylogenetic distribution, structural analysis and interaction of nucleotide excision repair proteins in cyanobacteria	4
How RNA impacts DNA repair	4
Processes shaping cancer genomes – From mitotic defects to chromosomal rearrangements	4
Fluorescently labeled human apurinic/apyrimidinic endonuclease APE1 reveals effects of DNA polymerase β on the APE1–DNA interaction	4
Interaction of Wwox with Brca1 and associated complex proteins prevents premature resection at double-strand breaks and aberrant homologous recombination	4
Genetic polymorphisms in DNA repair genes and hepatocellular carcinoma risk	4
Functional defects of cancer-associated MDC1 mutations in DNA damage repair	4
DNA glycosylase deficiency leads to decreased severity of lupus in the Polb-Y265C mouse model	4
Reversal of histone H2B mono-ubiquitination is required for replication stress recovery	4
Measurement of uracil-DNA glycosylase activity by matrix assisted laser desorption/ionization time-of-flight mass spectrometry technique	4
Metazoan nuclear pore complexes in gene regulation and genome stability	4
Damage-Net: A program for DNA repair meta-analysis identifies a network of novel repair genes that facilitate cancer evolution	3
DLG2 impairs dsDNA break repair and maintains genome integrity in neuroblastoma	3
A redox-sensitive iron-sulfur cluster in murine FAM72A controls its ability to degrade the nuclear form of uracil-DNA glycosylase	3
Histone H4 LRS mutations can attenuate UV mutagenesis without affecting PCNA ubiquitination or sumoylation	3
Divergent structures of Mammalian and gammaherpesvirus uracil DNA glycosylases confer distinct DNA binding and substrate activity	3
Chemopotentiating effects of low-dose fractionated radiation on cisplatin and paclitaxel in cervix cancer cell lines and normal fibroblasts from patients with cervix cancer	3
Functional analyses of single nucleotide polymorphic variants of the DNA glycosylase NEIL1 in sub-Saharan African populations	3
Mutagenic repair of a ZFN-induced double-strand break in yeast: Effects of cleavage site sequence and spacer size	3
Detection of DNA replication errors and 8-oxo-dGTP-mediated mutations in E. coli by Duplex DNA Sequencing	3
The impact of chromatin on double-strand break repair: Imaging tools and discoveries	3
Cell cycle-dependent radiosensitivity in mouse zygotes	3
Fanconi anemia and Aldehyde Degradation Deficiency Syndrome: Metabolism and DNA repair protect the genome and hematopoiesis from endogenous DNA damage	3
Defects in DNA damage responses in SWI/SNF mutant cells and their impact on immune responses	3
Loss of an ABC transporter in Arabidopsis thaliana confers hypersensitivity to the anti-cancer drug bleomycin	3
Widespread hydrogen bonding in the proteins of HIV-1 may confer carcinogenic risks to AIDS patients	3
Extrinsic proofreading	3
Nonhomologous DNA end joining of nucleosomal substrates in a purified system	3
Pold4, the fourth subunit of replicative polymerase δ, suppresses gene conversion in the immunoglobulin-variable gene in avian DT40 cells	3
FANCM branchpoint translocase: Master of traverse, reverse and adverse DNA repair	3
Potential cGAS-STING pathway functions in DNA damage responses, DNA replication and DNA repair	3
Live cell transcription-coupled nucleotide excision repair dynamics revisited	3
Yeast DNA polymerase η possesses two PIP-like motifs that bind PCNA and Rad6-Rad18 with different specificities	3
Transcription and genome integrity	3
A bibliometric analysis of research on R-loop: Landscapes, highlights and trending topics	3
A combination of direct reversion and nucleotide excision repair counters the mutagenic effects of DNA carboxymethylation	3