DNA Repair

Article	Citations
Comparing Mfd- and UvrD-dependent models of transcription coupled DNA repair in live Escherichia coli using single-molecule tracking	842280240
Editorial Board	842019380
New insights into abasic site repair and tolerance	84
Cancer type-dependent correlations between TP53 mutations and antitumor immunity	79
Excision repair of topoisomerase DNA-protein crosslinks (TOP-DPC)	60
Roles for 53BP1 in the repair of radiation-induced DNA double strand breaks	59
The MRE11 complex: A versatile toolkit for the repair of broken DNA	57
Mammalian DNA base excision repair: Dancing in the moonlight	56
Biomolecular condensates at sites of DNA damage: More than just a phase	50
Debulking of topoisomerase DNA-protein crosslinks (TOP-DPC) by the proteasome, non-proteasomal and non-proteolytic pathways	48
ADP-ribosylation of DNA and RNA	48
Defining R-loop classes and their contributions to genome instability	47
Recent advances in γH2AX biomarker-based genotoxicity assays: A marker of DNA damage and repair	45
Molecular origins of APOBEC-associated mutations in cancer	44
DNA mismatch repair-dependent DNA damage responses and cancer	40
DNA-protein crosslink formation by endogenous aldehydes and AP sites	36
The recent advances in non-homologous end-joining through the lens of lymphocyte development	36
Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair	35
The cerebellar degeneration in ataxia-telangiectasia: A case for genome instability	34
Towards DNA-damage induced autophagy: A Boolean model of p53-induced cell fate mechanisms	33
PARP1: Structural insights and pharmacological targets for inhibition	32
Targeting Wee1 kinase as a therapeutic approach in Hematological Malignancies	31
Consequences of compromised mitochondrial genome integrity	30
Towards a comprehensive view of 8-oxo-7,8-dihydro-2’-deoxyguanosine: Highlighting the intertwined roles of DNA damage and epigenetics in genomic instability	30
Coping with RNA damage with a focus on APE1, a BER enzyme at the crossroad between DNA damage repair and RNA processing/decay	29

Strand discrimination in DNA mismatch repair	29
How to fix DNA-protein crosslinks	28
Human DNA ligases in replication and repair	26
Oxidative DNA-protein crosslinks formed in mammalian cells by abasic site lyases involved in DNA repair	25
The evolving complexity of DNA damage foci: RNA, condensates and chromatin in DNA double-strand break repair	25
The role of the SWI/SNF chromatin remodelling complex in the response to DNA double strand breaks	25
Time for remodeling: SNF2-family DNA translocases in replication fork metabolism and human disease	25
Dealing with transcription-blocking DNA damage: Repair mechanisms, RNA polymerase II processing and human disorders	25
TREX1 – Apex predator of cytosolic DNA metabolism	25
XRCC1 – Strategies for coordinating and assembling a versatile DNA damage response	24
Roles for MDC1 in cancer development and treatment	24
PARPs’ impact on base excision DNA repair	24
Role of mtDNA disturbances in the pathogenesis of Alzheimer’s and Parkinson’s disease	24
P53 in the impaired lungs	24
Hypermutation in single-stranded DNA	23
Revisiting the BRCA-pathway through the lens of replication gap suppression	23
The SNM1A DNA repair nuclease	23
Signaling pathways involved in cell cycle arrest during the DNA breaks	23
NAD+-mediated regulation of mammalian base excision repair	22
Transcription-coupled nucleotide excision repair: New insights revealed by genomic approaches	22
Cellular response to endogenous DNA damage: DNA base modifications in gene expression regulation	22
EXO1: A tightly regulated nuclease	22
Expanding molecular roles of UV-DDB: Shining light on genome stability and cancer	21
DNA damage response and repair in osteosarcoma: Defects, regulation and therapeutic implications	21
Twenty years of t-loops: A case study for the importance of collaboration in molecular biology	21
NTHL1 in genomic integrity, aging and cancer	20
Impact of circadian disruption on health; SIRT1 and Telomeres	20
Single-stranded DNA damage: Protecting the single-stranded DNA from chemical attack	20
PRMT1 is critical to FEN1 expression and drug resistance in lung cancer cells	20
Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1	20
CRISPR/CAS9-based DNA damage response screens reveal gene-drug interactions	20
DNA helicases and their roles in cancer	20
Chromosome breaks generated by low doses of ionizing radiation in G2-phase are processed exclusively by gene conversion	19
Two main mutational processes operate in the absence of DNA mismatch repair	19
Understanding the sequence and structural context effects in oxidative DNA damage repair	18
Transcription coupled base excision repair in mammalian cells: So little is known and so much to uncover	18
GTPases, genome, actin: A hidden story in DNA damage response and repair mechanisms	18
Increased DNA repair capacity augments resistance of glioblastoma cells to photodynamic therapy	17
Mechanisms of direct replication restart at stressed replisomes	17
The dark side of homology-directed repair	16
Toxic R-loops: Cause or consequence of replication stress?	16
Significance and limitations of the use of next-generation sequencing technologies for detecting mutational signatures	16
Untangling trapped topoisomerases with tyrosyl-DNA phosphodiesterases	16
Formation and repair of unavoidable, endogenous interstrand cross-links in cellular DNA	16
Molecular and structural characterization of disease-associated APE1 polymorphisms	16
Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase 1 DNA-protein crosslinks and 3′-blocking lesions in the absence of tyrosyl-DNA phosphodiesterase 1 (TDP1)	15
Biochemical analysis of TOPBP1 oligomerization	15
Function and evolution of the DNA-protein crosslink proteases Wss1 and SPRTN	15
PARP1-mediated PARylation of TonEBP prevents R-loop–associated DNA damage	15
Daughter-strand gaps in DNA replication – substrates of lesion processing and initiators of distress signalling	15

Structure, function and evolution of the Helix-hairpin-Helix DNA glycosylase superfamily: Piecing together the evolutionary puzzle of DNA base damage repair mechanisms	15
Replication initiation: Implications in genome integrity	15
Molecular basis for the MacroD1-mediated hydrolysis of ADP-ribosylation	15
Large dataset of octocoral mitochondrial genomes provides new insights into mt-mutS evolution and function	15
The role of telomeres and telomerase in the senescence of postmitotic cells	15
CST in maintaining genome stability: Beyond telomeres	15
Helicobacter pylori severely reduces expression of DNA repair proteins PMS2 and ERCC1 in gastritis and gastric cancer	14
C17orf53 is identified as a novel gene involved in inter-strand crosslink repair	14
Cancer testis antigens and genomic instability: More than immunology	14
The role of DNA damage response in chemo- and radio-resistance of cancer cells: Can DDR inhibitors sole the problem?	14
Pol β gap filling, DNA ligation and substrate-product channeling during base excision repair opposite oxidized 5-methylcytosine modifications	14
Structural biology of DNA abasic site protection by SRAP proteins	14
Compromised repair of radiation-induced DNA double-strand breaks in Fanconi anemia fibroblasts in G2	13
Understanding the DNA double-strand break repair and its therapeutic implications	13
The meiosis-specific MEIOB–SPATA22 complex cooperates with RPA to form a compacted mixed MEIOB/SPATA22/RPA/ssDNA complex	13
Transcription-coupled repair and the transcriptional response to UV-Irradiation	13
DNA damage response and breast cancer development: Possible therapeutic applications of ATR, ATM, PARP, BRCA1 inhibition	13
mTOR pathway and DNA damage response: A therapeutic strategy in cancer therapy	13
The role of histone H3K36me3 writers, readers and erasers in maintaining genome stability	13
Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes	13
Non-canonical function of nuclear PTEN and its implication on tumorigenesis	12
Double strand break (DSB) repair in Cyanobacteria: Understanding the process in an ancient organism	12
Regulation of UV damage repair in quiescent yeast cells	12
Nucleophosmin interaction with APE1: Insights into DNA repair regulation	12
Transcription-coupled DNA double-strand break repair	12
New twists to the ALTernative endings at telomeres	12
HOTAIR beyond repression: In protein degradation, inflammation, DNA damage response, and cell signaling	12
Olaparib enhances curcumin-mediated apoptosis in oral cancer cells by inducing PARP trapping through modulation of BER and chromatin assembly	12
Role of histone acetyltransferases MOF and Tip60 in genome stability	12
The activity of the DNA repair enzyme hOGG1 can be directly modulated by ubiquinol	11
Perspectives on formaldehyde dysregulation: Mitochondrial DNA damage and repair in mammalian cells	11
DNA damage response and PD-1/PD-L1 pathway in ovarian cancer	11
The cross-talk between signaling pathways, noncoding RNAs and DNA damage response: Emerging players in cancer progression	11
Cyclin-dependent kinase inhibitors (CDKIs) and the DNA damage response: The link between signaling pathways and cancer	11
Transcriptional dysregulation of base excision repair proteins in breast cancer	11
Double-strand breaks: When DNA repair events accidentally meet	11
Non-canonical interaction of DNA repair proteins with intact and cleaved AP sites	11
Impacts of chromatin dynamics and compartmentalization on DNA repair	11
Fine-tuning of DNA base excision/strand break repair via acetylation	11
The dual role of DNA repair protein MGMT in cancer prevention and treatment	11
RNA helicase, DDX3X, is actively recruited to sites of DNA damage in live cells	11
MicroRNAs and the DNA damage response: How is cell fate determined?	11
Sp1-dependent recruitment of the histone acetylase p300 to DSBs facilitates chromatin remodeling and recruitment of the NHEJ repair factor Ku70	10
DNA polymerase β outperforms DNA polymerase γ in key mitochondrial base excision repair activities	10
The mismatch repair protein MSH6 regulates somatic recombination in Arabidopsis thaliana	10
Requirements for PARP-1 covalent crosslinking to DNA (PARP-1 DPC)	10
Molecular analysis directs the prognosis, management and treatment of patients with xeroderma pigmentosum	10
The “adductome”: A limited repertoire of adducted proteins in human cells	10
Chaperoning histones at the DNA repair dance	10
The multifaceted roles of DNA repair and replication proteins in aging and obesity	10
Proficiency in homologous recombination repair is prerequisite for activation of G2-checkpoint at low radiation doses	10
Alteration of genetic recombination and double-strand break repair in human cells by progerin expression	10
DNA mismatch repair in the chromatin context: Mechanisms and therapeutic potential	10
USP13 regulates the replication stress response by deubiquitinating TopBP1	10
PCNA, a focus on replication stress and the alternative lengthening of telomeres pathway	9
Telomere replication—When the going gets tough	9
miR-197-5p increases Doxorubicin-mediated anticancer cytotoxicity of HT1080 fibrosarcoma cells by decreasing drug efflux	9
Size-dependent antirecombinogenic effect of short spacers on palindrome recombinogenicity	9
Structural determinants of nucleobase modification recognition in the AlkB family of dioxygenases	9
Repair of DNA-protein crosslinks in plants	9
Hydroxychloroquine induces oxidative DNA damage and mutation in mammalian cells	9
DNA double-strand break repair in male germ cells during spermatogenesis and its association with male infertility development	8
Genome maintenance during embryogenesis	8
Multi-omic analysis of altered transcriptome and epigenetic signatures in the UV-induced DNA damage response	8
DNA damage-induced sumoylation of Sp1 induces its interaction with RNF4 and degradation in S phase to remove 53BP1 from DSBs and permit HR	8
Trinucleotide repeat instability via DNA base excision repair	8
NELF complex fosters BRCA1 and RAD51 recruitment to DNA damage sites and modulates sensitivity to PARP inhibition	8
The fast-growing business of Serine ADP-ribosylation	8
HPV induction of APOBEC3 enzymes mediate overall survival and response to cisplatin in head and neck cancer	8
Post-translational modification of factors involved in homologous recombination	8
Modulation of immune responses by DNA damage signaling	8
DNA repair pathways as guardians of the genome: Therapeutic potential and possible prognostic role in hematologic neoplasms	8
The RNF8 and RNF168 Ubiquitin Ligases Regulate Pro- and Anti-Resection Activities at Broken DNA Ends During Non-Homologous End Joining	8
The DNA ligands Arg47 and Arg76 are crucial for catalysis by human PrimPol	8
Sequence context effects of replication of Fapy•dG in three mutational hot spot sequences of the p53 gene in human cells	8
Shining light on single-strand lesions caused by the chemotherapy drug bleomycin	8
Analysis of mutational signatures in C. elegans: Implications for cancer genome analysis	8
Timely upstream events regulating nucleotide excision repair by ubiquitin-proteasome system: ubiquitin guides the way	8
Insights into the Direct Oxidative Repair of Etheno Lesions: MD and QM/MM Study on the Substrate Scope of ALKBH2 and AlkB	8
The burden of overweight: Higher body mass index, but not vital exhaustion, is associated with higher DNA damage and lower DNA repair capacity	7

DNA polymerase β: Closing the gap between structure and function	7
The FAcilitates Chromatin Transcription (FACT) complex: Its roles in DNA repair and implications for cancer therapy	7
Mysterious and fascinating: DNA polymerase ɩ remains enigmatic 20 years after its discovery	7
Ubiquitylation in DNA double-strand break repair	7
Variable impact of conformationally distinct DNA lesions on nucleosome structure and dynamics: Implications for nucleotide excision repair	7
Molecular dynamics simulations reveal how H3K56 acetylation impacts nucleosome structure to promote DNA exposure for lesion sensing	7
CometChip enables parallel analysis of multiple DNA repair activities	7
An open-source platform to quantify subnuclear foci and protein colocalization in response to replication stress	7
Histone variants H3.3 and H2A.Z/H3.3 facilitate excision of uracil from nucleosome core particles	7
Methylation of the central transcriptional regulator KLF4 by PRMT5 is required for DNA end resection and recombination	7
Alternative complexes formed by the Escherichia coli clamp loader accessory protein HolC (x) with replication protein HolD (ψ) and repair protein YoaA	7
O-GlcNAc transferase is important for homology-directed repair	7
The interactions between DNA methylation machinery and long non-coding RNAs in tumor progression and drug resistance	7
Mechanisms of genome stability maintenance during cell division	7
Paradoxical role of the major DNA repair protein, OGG1, in action-at-a-distance mutation induction by 8-oxo-7,8-dihydroguanine	7
DNA-protein crosslinks are repaired via homologous recombination in mammalian mitochondria	7
New complexities of SOS-induced “untargeted” mutagenesis in Escherichia coli as revealed by mutation accumulation and whole-genome sequencing	7
Tissue-specific reduction in MLH1 expression induces microsatellite instability in intestine of Mlh1 mice	7
Effect of sequence context on Polζ-dependent error-prone extension past (6-4) photoproducts	7
2-hexyl-4-pentynoic acid, a potential therapeutic for breast carcinoma by influencing RPA2 hyperphosphorylation-mediated DNA repair	7
Impaired DNA repair in mouse monocytes compared to macrophages and precursors	7
Repair of DNA double-strand breaks in RNAPI- and RNAPII-transcribed loci	6
DNA damage and regulation of protein homeostasis	6
XRCC3 loss leads to midgestational embryonic lethality in mice	6
The mRNA tether model for activation-induced deaminase and its relevance for Ig somatic hypermutation and class switch recombination	6
The DNA damage induced immune response: Implications for cancer therapy	6
To indel or not to indel: Factors influencing mutagenesis during chromosomal break end joining	6
How DNA damage and non-canonical nucleotides alter the telomerase catalytic cycle	6
Effects of radiotherapy and short-term starvation combination on metastatic and non-tumor cell lines	6
Three targets in one complex: A molecular perspective of TFIIH in cancer therapy	6
A DNA replication fork-centric view of the budding yeast DNA damage response	6
Variation in G-quadruplex sequence and topology differentially impacts human DNA polymerase fidelity	6
G-quadruplex resolution: From molecular mechanisms to physiological relevance	6
Kinetics model of DNA double-strand break repair in eukaryotes	6
Redirecting E2F1 to TA-p73 improves cancer therapy through apoptotic induction	6
History of DNA polymerase β X-ray crystallography	6
Mechanism for R-loop formation remote from the transcription start site: Topological issues and possible facilitation by dissociation of RNA polymerase	6
Biochemical characterization and mutational studies of a novel 3-methlyadenine DNA glycosylase II from the hyperthermophilic Thermococcus gammatolerans	6
UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1	6
XPA deficiency affects the ubiquitin-proteasome system function	6
RNA in DNA repair	6
Higher chromosome stability in embryonic neural stem and progenitor cells than in fibroblasts in response to acute or chronic genotoxic stress	6
Histone lysine modifying enzymes and their critical roles in DNA double-strand break repair	6
A novel DDB2 mutation causes defective recognition of UV-induced DNA damages and prevalent equine squamous cell carcinoma	6
Mechanisms of DNA repair in Trypanosoma cruzi: What do we know so far?	5
Obstacles and opportunities for base excision repair in chromatin	5
dCas9 binding inhibits the initiation of base excision repair in vitro	5
Deciphering the role of distinct DNA-PK phosphorylations at collapsed replication forks	5
Mutational analysis of Thermococcus kodakarensis Endonuclease III reveals the roles of evolutionarily conserved residues	5
Restoration of ligatable “clean” double-strand break ends is the rate-limiting step in the rejoining of ionizing-radiation-induced DNA breakage	5
A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein	5
Histone and Chromatin Dynamics Facilitating DNA repair	5
New insights into the DNA repair pathway choice with NuA4/TIP60	5
hMTH1 and GPX1 expression in human thyroid tissue is interrelated to prevent oxidative DNA damage	5
The Sm core components of small nuclear ribonucleoproteins promote homologous recombination repair	5
Set1-dependent H3K4 methylation becomes critical for limiting DNA damage in response to changes in S-phase dynamics in Saccharomyces cerevisiae	5
Chromatin dynamics and DNA replication roadblocks	5
Hydrogen peroxide and Helicobacter pylori extract treatment combined with APE1 knockdown induce DNA damage, G2/M arrest and cell death in gastric cancer cell line	5
Histone variants: The unsung guardians of the genome	5
The N-terminal domain of uracil-DNA glycosylase: Roles for disordered regions	5
Cockayne syndrome group B protein uses its DNA translocase activity to promote mitotic DNA synthesis	5
TOPBP1 regulates resistance of gastric cancer to oxaliplatin by promoting transcription of PARP1	5
Cross-linking of the DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of cisplatin	5
Fully automated counting of DNA damage foci in tumor cell culture: A matter of cell separation	5
Compartmentalization of the DNA damage response: Mechanisms and functions	5
Structural insights into an MsmUdgX mutant capable of both crosslinking and uracil excision capability	5
DNA glycosylases for 8-oxoguanine repair in Staphylococcus aureus	5
Impact of DNA sequences on DNA ‘opening’ by the Rad4/XPC nucleotide excision repair complex	5
The DNA damage-sensing NER repair factor XPC-RAD23B does not recognize bulky DNA lesions with a missing nucleotide opposite the lesion	5
DEF1: Much more than an RNA polymerase degradation factor	4
Collaborations between chromatin and nuclear architecture to optimize DNA repair fidelity	4
Mitochondrial apurinic/apyrimidinic endonuclease Apn1 is not critical for the completion of the Plasmodium berghei life cycle	4
DNA damage response and repair in pancreatic cancer development and therapy	4
Reported DNA repair protein CECR2, which is associated with neural tube defects in mice, is not required for double-strand break repair in primary neurospheres	4
RETRACTED: Thymoquinone sensitizes human hepatocarcinoma cells to TRAIL-induced apoptosis via oxidative DNA damage	4
The C-terminal domain of Arabidopsis ROS1 DNA demethylase interacts with histone H3 and is required for DNA binding and catalytic activity	4
Fluorescently labeled human apurinic/apyrimidinic endonuclease APE1 reveals effects of DNA polymerase β on the APE1–DNA interaction	4
Error-prone bypass patch by a low-fidelity variant of DNA polymerase zeta in human cells	4
Replication dependent and independent mechanisms of GAA repeat instability	4
Treatment of human cells with 5-aza-dC induces formation of PARP1-DNA covalent adducts at genomic regions targeted by DNMT1	4
Structure and mechanism in non-homologous end joining	4
Measurement of uracil-DNA glycosylase activity by matrix assisted laser desorption/ionization time-of-flight mass spectrometry technique	4
Genome integrity and inflammation in the nervous system	4
Role of the multifunctional transcription factor TFII-I in DNA damage repair	4
Low and high doses of ionizing radiation evoke discrete global (phospho)proteome responses	4
The rate of formation and stability of abasic site interstrand crosslinks in the DNA duplex	4
Multifunctional properties of Nej1XLF C-terminus promote end-joining and impact DNA double-strand break repair pathway choice	4
Plasmodium Ape1 is a multifunctional enzyme in mitochondrial base excision repair and is required for efficient transition from liver to blood stage infection	4
Heterogeneity of DNA damage incidence and repair in different chromatin contexts	4
Nanoscale insight into chromatin remodeling and DNA repair complex in HeLa cells after ionizing radiation	4
Single-molecule studies of helicases and translocases in prokaryotic genome-maintenance pathways	4
The multifaceted functions of homologous recombination in dealing with replication-associated DNA damages	4
Chk1 inhibition induces a DNA damage bystander effect in cocultured tumour cells	4
Mechanisms of SSBP1 variants in mitochondrial disease: Molecular dynamics simulations reveal stable tetramers with altered DNA binding surfaces	4
Chromosomal aberration dynamics through the cell cycle	4