DNA Repair

Article	Citations
Roles for 53BP1 in the repair of radiation-induced DNA double strand breaks	66
Mammalian DNA base excision repair: Dancing in the moonlight	62
ADP-ribosylation of DNA and RNA	61
The MRE11 complex: A versatile toolkit for the repair of broken DNA	61
Biomolecular condensates at sites of DNA damage: More than just a phase	56
Defining R-loop classes and their contributions to genome instability	55
Recent advances in γH2AX biomarker-based genotoxicity assays: A marker of DNA damage and repair	53
Debulking of topoisomerase DNA-protein crosslinks (TOP-DPC) by the proteasome, non-proteasomal and non-proteolytic pathways	53
Molecular origins of APOBEC-associated mutations in cancer	50
DNA mismatch repair-dependent DNA damage responses and cancer	45
Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair	40
The recent advances in non-homologous end-joining through the lens of lymphocyte development	36
The cerebellar degeneration in ataxia-telangiectasia: A case for genome instability	36
PARP1: Structural insights and pharmacological targets for inhibition	35
Towards DNA-damage induced autophagy: A Boolean model of p53-induced cell fate mechanisms	34
Strand discrimination in DNA mismatch repair	33
Towards a comprehensive view of 8-oxo-7,8-dihydro-2’-deoxyguanosine: Highlighting the intertwined roles of DNA damage and epigenetics in genomic instability	33
Targeting Wee1 kinase as a therapeutic approach in Hematological Malignancies	31
Revisiting the BRCA-pathway through the lens of replication gap suppression	31
Consequences of compromised mitochondrial genome integrity	31
The role of the SWI/SNF chromatin remodelling complex in the response to DNA double strand breaks	31
How to fix DNA-protein crosslinks	31
Coping with RNA damage with a focus on APE1, a BER enzyme at the crossroad between DNA damage repair and RNA processing/decay	29
TREX1 – Apex predator of cytosolic DNA metabolism	29
Role of mtDNA disturbances in the pathogenesis of Alzheimer’s and Parkinson’s disease	29

Human DNA ligases in replication and repair	28
The evolving complexity of DNA damage foci: RNA, condensates and chromatin in DNA double-strand break repair	28
Dealing with transcription-blocking DNA damage: Repair mechanisms, RNA polymerase II processing and human disorders	28
P53 in the impaired lungs	27
Roles for MDC1 in cancer development and treatment	27
Time for remodeling: SNF2-family DNA translocases in replication fork metabolism and human disease	27
PARPs’ impact on base excision DNA repair	27
The SNM1A DNA repair nuclease	26
NAD+-mediated regulation of mammalian base excision repair	26
XRCC1 – Strategies for coordinating and assembling a versatile DNA damage response	25
Hypermutation in single-stranded DNA	25
DNA damage response and repair in osteosarcoma: Defects, regulation and therapeutic implications	24
Twenty years of t-loops: A case study for the importance of collaboration in molecular biology	24
EXO1: A tightly regulated nuclease	24
Signaling pathways involved in cell cycle arrest during the DNA breaks	24
NTHL1 in genomic integrity, aging and cancer	23
Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1	23
The dark side of homology-directed repair	23
Cellular response to endogenous DNA damage: DNA base modifications in gene expression regulation	23
Transcription-coupled nucleotide excision repair: New insights revealed by genomic approaches	23
GTPases, genome, actin: A hidden story in DNA damage response and repair mechanisms	22
PRMT1 is critical to FEN1 expression and drug resistance in lung cancer cells	22
Expanding molecular roles of UV-DDB: Shining light on genome stability and cancer	21
Impact of circadian disruption on health; SIRT1 and Telomeres	21
DNA helicases and their roles in cancer	21
Transcription coupled base excision repair in mammalian cells: So little is known and so much to uncover	20
Formation and repair of unavoidable, endogenous interstrand cross-links in cellular DNA	20
Pol β gap filling, DNA ligation and substrate-product channeling during base excision repair opposite oxidized 5-methylcytosine modifications	19
Toxic R-loops: Cause or consequence of replication stress?	19
PARP1-mediated PARylation of TonEBP prevents R-loop–associated DNA damage	19
Understanding the sequence and structural context effects in oxidative DNA damage repair	19
Mechanisms of direct replication restart at stressed replisomes	18
The dual role of DNA repair protein MGMT in cancer prevention and treatment	18
The role of histone H3K36me3 writers, readers and erasers in maintaining genome stability	18
Increased DNA repair capacity augments resistance of glioblastoma cells to photodynamic therapy	18
Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase 1 DNA-protein crosslinks and 3′-blocking lesions in the absence of tyrosyl-DNA phosphodiesterase 1 (TDP1)	18
Large dataset of octocoral mitochondrial genomes provides new insights into mt-mutS evolution and function	18
Untangling trapped topoisomerases with tyrosyl-DNA phosphodiesterases	18
C17orf53 is identified as a novel gene involved in inter-strand crosslink repair	17
Biochemical analysis of TOPBP1 oligomerization	17
The role of DNA damage response in chemo- and radio-resistance of cancer cells: Can DDR inhibitors sole the problem?	17
Transcription-coupled DNA double-strand break repair	17
The role of telomeres and telomerase in the senescence of postmitotic cells	17
Structure, function and evolution of the Helix-hairpin-Helix DNA glycosylase superfamily: Piecing together the evolutionary puzzle of DNA base damage repair mechanisms	17
Replication initiation: Implications in genome integrity	16
HOTAIR beyond repression: In protein degradation, inflammation, DNA damage response, and cell signaling	16
Cancer testis antigens and genomic instability: More than immunology	16
Molecular and structural characterization of disease-associated APE1 polymorphisms	16
Significance and limitations of the use of next-generation sequencing technologies for detecting mutational signatures	16
CST in maintaining genome stability: Beyond telomeres	16

Structural biology of DNA abasic site protection by SRAP proteins	15
Molecular basis for the MacroD1-mediated hydrolysis of ADP-ribosylation	15
mTOR pathway and DNA damage response: A therapeutic strategy in cancer therapy	15
Understanding the DNA double-strand break repair and its therapeutic implications	15
Daughter-strand gaps in DNA replication – substrates of lesion processing and initiators of distress signalling	15
Transcription-coupled repair and the transcriptional response to UV-Irradiation	15
Chaperoning histones at the DNA repair dance	14
Role of histone acetyltransferases MOF and Tip60 in genome stability	14
Double strand break (DSB) repair in Cyanobacteria: Understanding the process in an ancient organism	13
Double-strand breaks: When DNA repair events accidentally meet	13
RNA helicase, DDX3X, is actively recruited to sites of DNA damage in live cells	13
DNA damage response and breast cancer development: Possible therapeutic applications of ATR, ATM, PARP, BRCA1 inhibition	13
DNA double-strand break repair in male germ cells during spermatogenesis and its association with male infertility development	13
Perspectives on formaldehyde dysregulation: Mitochondrial DNA damage and repair in mammalian cells	13
DNA damage response and PD-1/PD-L1 pathway in ovarian cancer	13
Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes	13
Cyclin-dependent kinase inhibitors (CDKIs) and the DNA damage response: The link between signaling pathways and cancer	13
Compromised repair of radiation-induced DNA double-strand breaks in Fanconi anemia fibroblasts in G2	13
New twists to the ALTernative endings at telomeres	13
DNA repair pathways as guardians of the genome: Therapeutic potential and possible prognostic role in hematologic neoplasms	13
The meiosis-specific MEIOB–SPATA22 complex cooperates with RPA to form a compacted mixed MEIOB/SPATA22/RPA/ssDNA complex	13
Sp1-dependent recruitment of the histone acetylase p300 to DSBs facilitates chromatin remodeling and recruitment of the NHEJ repair factor Ku70	12
Impacts of chromatin dynamics and compartmentalization on DNA repair	12
Olaparib enhances curcumin-mediated apoptosis in oral cancer cells by inducing PARP trapping through modulation of BER and chromatin assembly	12
MicroRNAs and the DNA damage response: How is cell fate determined?	12
Non-canonical function of nuclear PTEN and its implication on tumorigenesis	12
miR-197-5p increases Doxorubicin-mediated anticancer cytotoxicity of HT1080 fibrosarcoma cells by decreasing drug efflux	11
A DNA replication fork-centric view of the budding yeast DNA damage response	11
Alteration of genetic recombination and double-strand break repair in human cells by progerin expression	11
Hydroxychloroquine induces oxidative DNA damage and mutation in mammalian cells	11
Transcriptional dysregulation of base excision repair proteins in breast cancer	11
Fine-tuning of DNA base excision/strand break repair via acetylation	11
The cross-talk between signaling pathways, noncoding RNAs and DNA damage response: Emerging players in cancer progression	11
USP13 regulates the replication stress response by deubiquitinating TopBP1	11
DNA polymerase β outperforms DNA polymerase γ in key mitochondrial base excision repair activities	11
PCNA, a focus on replication stress and the alternative lengthening of telomeres pathway	11
DNA mismatch repair in the chromatin context: Mechanisms and therapeutic potential	11
The multifaceted roles of DNA repair and replication proteins in aging and obesity	11
Tissue-specific reduction in MLH1 expression induces microsatellite instability in intestine of Mlh1 mice	10
G-quadruplex resolution: From molecular mechanisms to physiological relevance	10
Molecular dynamics simulations reveal how H3K56 acetylation impacts nucleosome structure to promote DNA exposure for lesion sensing	10
Molecular analysis directs the prognosis, management and treatment of patients with xeroderma pigmentosum	10
DNA damage and regulation of protein homeostasis	10
Post-translational modification of factors involved in homologous recombination	10
Telomere replication—When the going gets tough	10
Sequence context effects of replication of Fapy•dG in three mutational hot spot sequences of the p53 gene in human cells	10
Proficiency in homologous recombination repair is prerequisite for activation of G2-checkpoint at low radiation doses	10
Histone variants: The unsung guardians of the genome	10
DNA damage-induced sumoylation of Sp1 induces its interaction with RNF4 and degradation in S phase to remove 53BP1 from DSBs and permit HR	10
Histone and Chromatin Dynamics Facilitating DNA repair	9
The DNA ligands Arg47 and Arg76 are crucial for catalysis by human PrimPol	9
Shining light on single-strand lesions caused by the chemotherapy drug bleomycin	9
The interactions between DNA methylation machinery and long non-coding RNAs in tumor progression and drug resistance	9
Trinucleotide repeat instability via DNA base excision repair	9
UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1	9
To indel or not to indel: Factors influencing mutagenesis during chromosomal break end joining	9
Structural determinants of nucleobase modification recognition in the AlkB family of dioxygenases	9
The FAcilitates Chromatin Transcription (FACT) complex: Its roles in DNA repair and implications for cancer therapy	9
Genome maintenance during embryogenesis	9
Modulation of immune responses by DNA damage signaling	9
NELF complex fosters BRCA1 and RAD51 recruitment to DNA damage sites and modulates sensitivity to PARP inhibition	9
Variation in G-quadruplex sequence and topology differentially impacts human DNA polymerase fidelity	8
O-GlcNAc transferase is important for homology-directed repair	8
Analysis of mutational signatures in C. elegans: Implications for cancer genome analysis	8
Timely upstream events regulating nucleotide excision repair by ubiquitin-proteasome system: ubiquitin guides the way	8
Histone variants H3.3 and H2A.Z/H3.3 facilitate excision of uracil from nucleosome core particles	8
The fast-growing business of Serine ADP-ribosylation	8
Methylation of the central transcriptional regulator KLF4 by PRMT5 is required for DNA end resection and recombination	8
Multi-omic analysis of altered transcriptome and epigenetic signatures in the UV-induced DNA damage response	8
Paradoxical role of the major DNA repair protein, OGG1, in action-at-a-distance mutation induction by 8-oxo-7,8-dihydroguanine	8
DNA-protein crosslinks are repaired via homologous recombination in mammalian mitochondria	8
Insights into the Direct Oxidative Repair of Etheno Lesions: MD and QM/MM Study on the Substrate Scope of ALKBH2 and AlkB	8
New insights into the DNA repair pathway choice with NuA4/TIP60	8
Alternative complexes formed by the Escherichia coli clamp loader accessory protein HolC (x) with replication protein HolD (ψ) and repair protein YoaA	8
CometChip enables parallel analysis of multiple DNA repair activities	8
The burden of overweight: Higher body mass index, but not vital exhaustion, is associated with higher DNA damage and lower DNA repair capacity	8
History of DNA polymerase β X-ray crystallography	8
The RNF8 and RNF168 Ubiquitin Ligases Regulate Pro- and Anti-Resection Activities at Broken DNA Ends During Non-Homologous End Joining	8
An open-source platform to quantify subnuclear foci and protein colocalization in response to replication stress	7
Effects of radiotherapy and short-term starvation combination on metastatic and non-tumor cell lines	7

Mysterious and fascinating: DNA polymerase ɩ remains enigmatic 20 years after its discovery	7
The multifaceted functions of homologous recombination in dealing with replication-associated DNA damages	7
Ubiquitylation in DNA double-strand break repair	7
The DNA damage induced immune response: Implications for cancer therapy	7
The N-terminal domain of uracil-DNA glycosylase: Roles for disordered regions	7
Mechanisms of genome stability maintenance during cell division	7
Repair of DNA double-strand breaks in RNAPI- and RNAPII-transcribed loci	7
The Sm core components of small nuclear ribonucleoproteins promote homologous recombination repair	7
Compartmentalization of the DNA damage response: Mechanisms and functions	7
Kinetics model of DNA double-strand break repair in eukaryotes	7
Impaired DNA repair in mouse monocytes compared to macrophages and precursors	7
Impact of DNA sequences on DNA ‘opening’ by the Rad4/XPC nucleotide excision repair complex	7
A novel DDB2 mutation causes defective recognition of UV-induced DNA damages and prevalent equine squamous cell carcinoma	7
Three targets in one complex: A molecular perspective of TFIIH in cancer therapy	7
RNA in DNA repair	7
The mRNA tether model for activation-induced deaminase and its relevance for Ig somatic hypermutation and class switch recombination	7
2-hexyl-4-pentynoic acid, a potential therapeutic for breast carcinoma by influencing RPA2 hyperphosphorylation-mediated DNA repair	7
DNA polymerase β: Closing the gap between structure and function	7
Biochemical characterization and mutational studies of a novel 3-methlyadenine DNA glycosylase II from the hyperthermophilic Thermococcus gammatolerans	6
XPA deficiency affects the ubiquitin-proteasome system function	6
Chromatin dynamics and DNA replication roadblocks	6
Cockayne syndrome group B protein uses its DNA translocase activity to promote mitotic DNA synthesis	6
Pan-cancer antagonistic inhibition pattern of ATM-driven G2/M checkpoint pathway vs other DNA repair pathways	6
Modifications and interactions at the R-loop	6
Genome integrity and inflammation in the nervous system	6
Low and high doses of ionizing radiation evoke discrete global (phospho)proteome responses	6
Mechanism for R-loop formation remote from the transcription start site: Topological issues and possible facilitation by dissociation of RNA polymerase	6
TOPBP1 regulates resistance of gastric cancer to oxaliplatin by promoting transcription of PARP1	6
XRCC3 loss leads to midgestational embryonic lethality in mice	6
Deciphering the role of distinct DNA-PK phosphorylations at collapsed replication forks	6
Histone lysine modifying enzymes and their critical roles in DNA double-strand break repair	6
How DNA damage and non-canonical nucleotides alter the telomerase catalytic cycle	6
Unpaved roads: How the DNA damage response navigates endogenous genotoxins	5
Real-time investigation of the roles of ATP hydrolysis by UvrA and UvrB during DNA damage recognition in nucleotide excision repair	5
Structure and mechanism in non-homologous end joining	5
dCas9 binding inhibits the initiation of base excision repair in vitro	5
Structural insights into an MsmUdgX mutant capable of both crosslinking and uracil excision capability	5
Mechanisms of SSBP1 variants in mitochondrial disease: Molecular dynamics simulations reveal stable tetramers with altered DNA binding surfaces	5
DNA glycosylases for 8-oxoguanine repair in Staphylococcus aureus	5
A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein	5
The DNA damage-sensing NER repair factor XPC-RAD23B does not recognize bulky DNA lesions with a missing nucleotide opposite the lesion	5
Tyrosyl-DNA phosphodiesterase 1 excises the 3′-DNA-ALKBH1 cross-link and its application for 3′-DNA-ALKBH1 cross-link characterization by LC-MS/MS	5
Mechanisms of DNA repair in Trypanosoma cruzi: What do we know so far?	5
DNA damage response and repair in pancreatic cancer development and therapy	5
Obstacles and opportunities for base excision repair in chromatin	5
Set1-dependent H3K4 methylation becomes critical for limiting DNA damage in response to changes in S-phase dynamics in Saccharomyces cerevisiae	5
Restoration of ligatable “clean” double-strand break ends is the rate-limiting step in the rejoining of ionizing-radiation-induced DNA breakage	5
Hydrogen peroxide and Helicobacter pylori extract treatment combined with APE1 knockdown induce DNA damage, G2/M arrest and cell death in gastric cancer cell line	5
Replication dependent and independent mechanisms of GAA repeat instability	5
Mitochondrial apurinic/apyrimidinic endonuclease Apn1 is not critical for the completion of the Plasmodium berghei life cycle	5
Post-translational regulation of Tyrosyl-DNA phosphodiesterase (TDP1 and TDP2) for the repair of the trapped topoisomerase-DNA covalent complex	5
hMTH1 and GPX1 expression in human thyroid tissue is interrelated to prevent oxidative DNA damage	5
Fully automated counting of DNA damage foci in tumor cell culture: A matter of cell separation	5
Chk1 inhibition induces a DNA damage bystander effect in cocultured tumour cells	5
Double-strand break repair and mis-repair in 3D	5
Error-prone bypass patch by a low-fidelity variant of DNA polymerase zeta in human cells	5
Plasmodium Ape1 is a multifunctional enzyme in mitochondrial base excision repair and is required for efficient transition from liver to blood stage infection	5
Treatment of human cells with 5-aza-dC induces formation of PARP1-DNA covalent adducts at genomic regions targeted by DNMT1	5
Heterogeneity of DNA damage incidence and repair in different chromatin contexts	5
DNA glycosylase deficiency leads to decreased severity of lupus in the Polb-Y265C mouse model	4
Increased contribution of DNA polymerase delta to the leading strand replication in yeast with an impaired CMG helicase complex	4
Dynamic action of DNA repair proteins as revealed by single molecule techniques: Seeing is believing	4
CTF18-RFC contributes to cellular tolerance against chain-terminating nucleoside analogs (CTNAs) in cooperation with proofreading exonuclease activity of DNA polymerase ε	4
Reported DNA repair protein CECR2, which is associated with neural tube defects in mice, is not required for double-strand break repair in primary neurospheres	4
Role of the multifunctional transcription factor TFII-I in DNA damage repair	4
Phospho-SIM and exon8b of PML protein regulate formation of doxorubicin-induced rDNA-PML compartment	4
Incorporation of 5’,8-cyclo-2’deoxyadenosines by DNA repair polymerases via base excision repair	4
The rate of formation and stability of abasic site interstrand crosslinks in the DNA duplex	4
Processes shaping cancer genomes – From mitotic defects to chromosomal rearrangements	4
Collaborations between chromatin and nuclear architecture to optimize DNA repair fidelity	4
Genetic polymorphisms in DNA repair genes and hepatocellular carcinoma risk	4
Rrp1, Rrp2 and Uls1 – Yeast SWI2/SNF2 DNA dependent translocases in genome stability maintenance	4
The ataxia-telangiectasia mutated gene product regulates the cellular acid-labile sulfide fraction	4
Open gaps in the evolution of the eukaryotic nucleotide excision repair	4
Single-molecule studies of helicases and translocases in prokaryotic genome-maintenance pathways	4
Measurement of uracil-DNA glycosylase activity by matrix assisted laser desorption/ionization time-of-flight mass spectrometry technique	4
RETRACTED: Thymoquinone sensitizes human hepatocarcinoma cells to TRAIL-induced apoptosis via oxidative DNA damage	4
Genomic stress and impaired DNA repair in Alzheimer disease	4
Mlh1 interacts with both Msh2 and Msh6 for recruitment during mismatch repair	4
Corruption of DNA end-joining in mammalian chromosomes by progerin expression	4
Polymorphic variant Asp239Tyr of human DNA glycosylase NTHL1 is inactive for removal of a variety of oxidatively-induced DNA base lesions from genomic DNA	4
DNA repair gene polymorphisms and chromosomal aberrations in healthy, nonsmoking population	4
Polβ/XRCC1 heterodimerization dictates DNA damage recognition and basal Polβ protein levels without interfering with mouse viability or fertility	4
Multifunctional properties of Nej1XLF C-terminus promote end-joining and impact DNA double-strand break repair pathway choice	4
Live cell single-molecule imaging to study DNA repair in human cells	4
Functional defects of cancer-associated MDC1 mutations in DNA damage repair	4
Centromere: A Trojan horse for genome stability	4
Nanoscale insight into chromatin remodeling and DNA repair complex in HeLa cells after ionizing radiation	4
Phylogenetic distribution, structural analysis and interaction of nucleotide excision repair proteins in cyanobacteria	4
The C-terminal domain of Arabidopsis ROS1 DNA demethylase interacts with histone H3 and is required for DNA binding and catalytic activity	4
Interaction of Wwox with Brca1 and associated complex proteins prevents premature resection at double-strand breaks and aberrant homologous recombination	4
Chromatin meets the cytoskeleton: the importance of nuclear actin dynamics and associated motors for genome stability	4
Fluorescently labeled human apurinic/apyrimidinic endonuclease APE1 reveals effects of DNA polymerase β on the APE1–DNA interaction	4
Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication	4
DEF1: Much more than an RNA polymerase degradation factor	4