DNA Repair

Article	Citations
Active genome integrity	68
DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining	62
Spatial mapping of the DNA adducts in cancer	56
Suppressors of Blm-deficiency identify three novel proteins that facilitate DNA repair in Ustilago maydis	46
Activation of Escherichia coli RecA* in recA730 lexA+ and recA730 lexA(Def) strain backgrounds	43
From DNA repair to neurodegeneration: PARP1 mechanisms and inhibitor strategies in Alzheimer’s disease	42
Contents of previous 3 special issues in this series of perspectives	35
Regulatory apoptotic fragment of PARP1 complements catalytic fragment for PAR and DNA-dependent activity but inhibits DNA-induced catalytic stimulation of PARP2	32
Building an integrated view of R-loops, transcription, and chromatin	29
Editors’ note Penny Jeggo and Bennett Van Houten	29
Stressed? Break-induced replication comes to the rescue!	28
Single-molecule approaches for DNA damage detection and repair: A focus on Repair Assisted Damage Detection (RADD)	28
The role of human PrimPol active site residue Gln48 in catalysis and complex formation with DNA	26
From cooperation to conflicts – A complicated relationship between transcription and replication	25
Single-molecule imaging of genome maintenance proteins encountering specific DNA sequences and structures	24
Harnessing R-loop dynamics: Challenging cancer therapy resistance	24
Editors’ Note	24
Irc20 modulates LOH frequency and distribution in S. cerevisiae	22
Corruption of DNA end-joining in mammalian chromosomes by progerin expression	22
Editorial Board	21
Comparing Mfd- and UvrD-dependent models of transcription coupled DNA repair in live Escherichia coli using single-molecule tracking	21
The B cell dilemma: Diversity or fidelity?	21
PARP1-PROTACs providing novel opportunities in precision oncology by targeting DNA damage response	20
DNA damage response and genomic instability disorder: Meeting report of the 20th Ataxia-Telangiectasia Workshop (ATW-2024) in conjunction with the 15th international symposium on DNA damage response &	20
PARP inhibitors in ovarian cancer: Mechanisms of resistance and implications to therapy	20

Chromatin meets the cytoskeleton: the importance of nuclear actin dynamics and associated motors for genome stability	19
A novel Family V uracil DNA glycosylase from Sulfolobus islandicus REY15A	19
What are the DNA lesions underlying formaldehyde toxicity?	19
Positioning loss of PARP1 activity as the central toxic event in BRCA-deficient cancer	19
Targeting base excision repair in precision oncology	18
Editorial Board	18
DNA repair-related heritable photosensitivity syndromes: Mutation landscape in a multiethnic cohort of 17 multigenerational families with high degree of consanguinity	18
The differential roles of rad9 alternatively spliced forms in double- strand DNA break repair during Drosophila meiosis	17
Metazoan nuclear pore complexes in gene regulation and genome stability	17
DNA synthesis across DNA hairpins by human PrimPol	17
The role of SLFN11 in DNA replication stress response and its implications for the Fanconi anemia pathway	17
Double-strand break repair and mis-repair in 3D	17
The interferon response at the intersection of genome integrity and innate immunity	17
Protein-protein interactions in the core nucleotide excision repair pathway	16
Using the safety scissors: DNA resection regulation at DNA double-strand breaks and telomeres	16
Editorial Board	16
Long-range PCR as a tool for evaluating mitochondrial DNA damage: Principles, benefits, and limitations of the technique	15
Richard Gatti: From concert pianist to bone marrow transplants and the DNA damage response syndrome, ataxia-telangiectasia	15
Centromere: A Trojan horse for genome stability	15
Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory	15
Variation in G-quadruplex sequence and topology differentially impacts human DNA polymerase fidelity	15
Chromosomal single-strand break repair and neurological disease: Implications on transcription and emerging genomic tools	15
The multifaceted roles of the Ctf4 replisome hub in the maintenance of genome integrity	15
NBS1 binds directly to TOPBP1 via disparate interactions between the NBS1 BRCT1 domain and the TOPBP1 BRCT1 and BRCT2 domains	14
One-ended and two-ended breaks at nickase-broken replication forks	14
DNA-repair and transcriptional defects drive hematologic malignancies in xeroderma pigmentosum group C patients: A new hypothesis	14
Somatic mutation patterns at Ig and Non-Ig Loci	13
Endogenous base damage as a driver of genomic instability in homologous recombination-deficient cancers	13
miR-185–5p rewires cisplatin resistance by restoring miR-203a-3p expression via downregulation of SOX9	13
Impairment of the non-catalytic subunit Dpb2 of DNA Pol ɛ results in increased involvement of Pol δ on the leading strand	13
Altered pathways in Cockayne syndrome: Involvement of MAPK, PI3K-Akt, extracellular matrix, inflammation, and neuronal signaling	13
Altered lipid profile in mice lacking the DNA repair protein ERCC1	13
Cutting Edge Perspectives in genome maintenance X	13
Inhibition of human DNA alkylation damage repair enzyme ALKBH2 by HIV protease inhibitor ritonavir	13
Presenilin-1, mutated in familial Alzheimer’s disease, maintains genome stability via a γ-secretase dependent way	12
Insight into meiotic DNA end resection: Mechanisms and regulation	12
Reversible association of ubiquitin with PCNA is important for template switching in S. cerevisiae	12
Frailty, sex, and poverty are associated with DNA damage and repair in frail, middle-aged urban adults	12
TFIIH central activity in nucleotide excision repair to prevent disease	12
DNA Repair Special Issue: Genome maintenance pathways in cancer - etiology, biomarkers and targets	12
Corrigendum to “Role of NEIL1 in genome maintenance” [DNA Repair 148 (2025) 103820]	12
Weaponizing CRISPR/Cas9 for selective elimination of cells with an aberrant genome	12
Editorial Board	12
Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhances alkylating agent and PARG inhibition induced cytotoxicity	12
Contents of previous 3 special issues in this series of perspectives	12
BRCA1 and BRCA2 in DNA damage and replication stress response: Insights into their functions, mechanisms, and implications for cancer treatment	12
A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein	11
RNF4 prevents genomic instability caused by chronic DNA under-replication	11
The flap endonuclease-1 mediated maturation of Okazaki fragments is critical for the cellular tolerance to remdesivir	11
How DNA secondary structures drive replication fork instability	11

C-terminal residues of DNA polymerase β and E3 ligase required for ubiquitin-linked proteolysis of oxidative DNA-protein crosslinks	11
Mechanisms and regulation of replication fork reversal	11
Small-molecule activator of SMUG1 enhances repair of pyrimidine lesions in DNA	11
Obituary	10
Remdesivir triphosphate is a valid substrate to initiate synthesis of DNA primers by human PrimPol	10
Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication	10
Mlh1 interacts with both Msh2 and Msh6 for recruitment during mismatch repair	10
Probing the structure and function of polymerase θ helicase-like domain	10
KBM-mediated interactions with KU80 promote cellular resistance to DNA replication stress in CHO cells	10
A special issue: DNA damage response in disease and therapy	10
Regulation of DNA damage-induced HLA class I presentation	10
USP1 in regulation of DNA repair pathways	10
The replication stress response: Mechanisms and functions	9
Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates	9
SMC-5/6 complex subunit NSE-1 plays a crucial role in meiosis and DNA repair in Caenorhabditis elegans	9
Compartmentalization of the DNA damage response: Mechanisms and functions	9
Phylogenetic distribution, structural analysis and interaction of nucleotide excision repair proteins in cyanobacteria	9
Variants in the first methionine of RAD51C are homologous recombination proficient due to an alternative start site	9
Discovery of KPT-6566 as STAG1/2 Inhibitor sensitizing PARP and NHEJ Inhibitors to suppress tumor cells growth in vitro	9
Emerging connections: Poly(ADP-ribose), FET proteins and RNA in the regulation of DNA damage condensates	9
Therapeutic targeting of mismatch repair proteins in triplet repeat expansion diseases	9
DONSON: Slding in 2 the limelight	9
Screening of glycosylase activity on oxidative derivatives of methylcytosine: Pedobacter heparinus SMUG2 as a formylcytosine- and carboxylcytosine-DNA glycosylase	9
Genome integrity and inflammation in the nervous system	9
DNA lesions that block transcription induce the death of Trypanosoma cruzi via ATR activation, which is dependent on the presence of R-loops	9
Cutting edge perspectives in genome maintenance XI	9
Tribute to life and science of Grigory (Gosha) Dianov	8
From rest to repair: Safeguarding genomic integrity in quiescent cells	8
Errol Friedberg: A life in writing	8
Replication initiation sites and zones in the mammalian genome: Where are they located and how are they defined?	8
Reversal of histone H2B mono-ubiquitination is required for replication stress recovery	8
Temporal and spatial dynamics of DNA double-strand break repair centers	8
Structure and mechanism in non-homologous end joining	8
Deletions initiated by the vaccinia virus TopIB protein in yeast	8
Why the ROS matters: One-electron oxidants focus DNA damage and repair on G-quadruplexes for gene regulation	8
LncRNA LINC01664 promotes cancer resistance through facilitating homologous recombination-mediated DNA repair	8
Editorial Board	8
Live cell single-molecule imaging to study DNA repair in human cells	8
The role of histone H3K36me3 writers, readers and erasers in maintaining genome stability	8
The biochemistry of the carcinogenic alcohol metabolite acetaldehyde	8
Biochemical characterization and mutational studies of endonuclease Q from the hyperthermophilic euryarchaeon Thermococcus gammatolerans	8
PARPs and ADP-ribosyl hydrolases in cancer therapy: From drug targets to biomarkers	8
Real-time single-molecule visualization using DNA curtains reveals the molecular mechanisms underlying DNA repair pathways	8
Editorial Board	8
The fast-growing business of Serine ADP-ribosylation	8
DNA damage repair (DDR) related prognostic risk model in multiple myeloma based on single-cell and bulk sequencing	8
Structure, function and evolution of the HerA subfamily proteins	8
Interaction of mitoxantrone with abasic sites - DNA strand cleavage and inhibition of apurinic/apyrimidinic endonuclease 1, APE1	7
The nucleotide excision repair proteins through the lens of molecular dynamics simulations	7
APE1 is a master regulator of the ATR-/ATM-mediated DNA damage response	7
Determinants governing BRC function evaluated by mutational analysis of Brh2 in Ustilago maydis	7
Holding it together: DNA end synapsis during non-homologous end joining	7
Editorial Board	7
DNA polymerase δ: A single Pol31 polymorphism suppresses the strain background-specific lethality of Pol32 inactivation in Saccharomyces cerevisiae	7
FBH1 and the replication stress response: Implications for genome stability and cancer development	7
S-palmitoylation: An oily modification guardinggenome stability	7
Repair of genomic interstrand crosslinks	7
C. elegans ribosomal protein S3 protects against H2O2-induced DNA damage and suppresses spontaneous mutations in yeast	7
BCLAF1, a functional partner of BACH1, participates in DNA damage response	7
The roles of non-productive complexes of DNA repair proteins with DNA lesions	7
Multiple functions of PARP1 in the repair of DNA double strand breaks	7
Cockayne syndrome group B protein uses its DNA translocase activity to promote mitotic DNA synthesis	6
The Ataxia-telangiectasia mutated (ATM) is the most important gene for repairing the DNA in Myelodysplastic Neoplasm	6
The analysis of protein recruitment to laser microirradiation-induced DNA damage in live cells: Best practices for data analysis	6
Bulk synthesis and beyond: The roles of eukaryotic replicative DNA polymerases	6
Modulation of OGG1 enzymatic activity by the cellular machinery – have all the boxes been ticked?	6
To divide or not to divide? NAC8 (SOG1) as a key regulator of DNA damage response in barley (Hordeum vulgare L.)	6
Functions of PMS2 and MLH1 important for regulation of divergent repeat-mediated deletions	6
DNA repair pathways in the mitochondria	6
A-T neurodegeneration and DNA damage-induced transcriptional stress	6
Global screening of base excision repair in nucleosome core particles	6
Monitoring DNA polymerase β mitochondrial localization and dynamics	6
Partial deletions of the autoregulatory C-terminal domain of Artemis and their effect on its nuclease activity	5
Overexpression of the WWE domain of RNF146 modulates poly-(ADP)-ribose dynamics at sites of DNA damage	5
Polymerase theta: Genome protection through regulated deployment	5
Biochemical analysis of H2O2-induced mutation spectra revealed that multiple damages were involved in the mutational process	5
O-GlcNAc transferase is important for homology-directed repair	5
FAM21 interacts with Ku to promote the localization of WASH to DNA double strand break sites	5
Joining of DNA breaks- interplay between DNA ligases and poly (ADP-ribose) polymerases	5
Targeting DNA damage sensors for cancer therapy	5

Phosphoregulation of the checkpoint kinase Mec1ATR	5
Live cell transcription-coupled nucleotide excision repair dynamics revisited	5
‘From R-lupus to cancer’: Reviewing the role of R-loops in innate immune responses	5
A tale of two mechanisms: Clarification of the pathway for MBD4 catalyzed glycosidic bond cleavage using MD and QM/MM calculations	5
Evolution of the triplet BRCT domain	5
Mediator complex in transcription regulation and DNA repair: Relevance for human diseases	5
The DNA damage induced immune response: Implications for cancer therapy	5
53BP1-the ‘Pandora’s box’ of genome integrity	5
Genomic stress and impaired DNA repair in Alzheimer disease	5
UVSSA facilitates transcription-coupled repair of DNA interstrand crosslinks	5
Kinome-wide screening uncovers a role for Bromodomain Protein 3 in DNA double-stranded break repair	5
Microglial inflammation in genome instability: A neurodegenerative perspective	5
Single-molecule toxicogenomics: Optical genome mapping of DNA-damage in nanochannel arrays	5
Lawrence H. Thompson: A life of bikes, birds, and DNA repair (1941–2024)	5
Temporal recruitment of base excision DNA repair factors in living cells in response to different micro-irradiation DNA damage protocols	5
MLH1 silencing reprograms PI3K/AKT and JAK/STAT signaling to enhance 5-Fluorouracil sensitivity in colorectal cancer cells	5
Compared to other NHEJ factors, DNA-PK protein and RNA levels are markedly increased in all higher primates, but not in prosimians or other mammals	5
SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice	5
DNA G-quadruplexes: Structural and functional insights	5
The C-terminal tail of Rad17, iVERGE, binds the 9‒1‒1 complex independently of AAA+ ATPase domains to provide another clamp–loader interface	5
Editorial Board	5
Clinical evidence for a role of E2F1-induced replication stress in modulating tumor mutational burden and immune microenvironment	4
DNA topoisomerase IIß inhibition blocks DNA end resection and synergizes with PARPi in BRCA1-deficient models	4
Unveiling cGAS mechanisms: Insights into DNA damage and immune sensing in cancer	4
DNA repair deficiencies and neurodegeneration	4
How to write an ending: Telomere replication as a multistep process	4
Synergistic effects on mutagenicity of tandem lesions containing 8-oxo-7,8-dihydro-2′-deoxyguanosine or Fapy•dG flanked by a 3′ 5-formyl-2′-deoxyuridine in human cells	4
The role of DNA repair deficiency in lipid accumulation: A proof-of-concept study	4
Recent advances in understanding the molecular mechanisms of SLX4 recruitment in the replication stress response	4
Spatio-temporal dynamics of the DNA glycosylase OGG1 in finding and processing 8-oxoguanine	4
Rrp1, Rrp2 and Uls1 – Yeast SWI2/SNF2 DNA dependent translocases in genome stability maintenance	4
Saccharomyces cerevisiae apurinic/apyrimidinic endonuclease 1 repairs abasic site-mediated DNA-peptide/protein cross-links	4
Spontaneous and salt stress-induced molecular instability in the progeny of MSH7 deficient Arabidopsis thaliana plants	4
Editorial Board	4
Transcription reprogramming and endogenous DNA damage	4
Editors’ note on “p21CDKN1A participates in base excision repair by regulating the activity of poly(ADP-ribose) polymerase-1”	4
Contributions of DNA double strand break repair pathways to DNA crosslink repair	4
Checkpoint activation and recovery: regulation of the 9–1–1 axis by the PP2A phosphatase	4
Editorial	4
FBH1 deficiency sensitizes cells to WEE1 inhibition by promoting mitotic catastrophe	4
The nuclear structural protein NuMA is required for efficient DNA replication and supports the association of core replication factors to replication forks	4
Editorial Board	4
Helicase activities of Rad5 and Rrm3 genetically interact in the prevention of recombinogenic DNA lesions in Saccharomyces cerevisiae	4
A bibliometric analysis of research on R-loop: Landscapes, highlights and trending topics	4
Intersection of the fragile X-related disorders and the DNA damage response	3
Genome organization and stability in mammalian pre-implantation development	3
NEIL3 promotes cell proliferation of ccRCC via the cyclin D1-Rb-E2F1 feedback loop regulation	3
How RNA impacts DNA repair	3
A redox-sensitive iron-sulfur cluster in murine FAM72A controls its ability to degrade the nuclear form of uracil-DNA glycosylase	3
The interactions between DNA methylation machinery and long non-coding RNAs in tumor progression and drug resistance	3
Development and characterization of a novel NEIL1 nanobody	3
DNA damage response inhibitors in cancer therapy: Mechanisms, clinical development, and combination strategies	3
The HNH endonuclease domain of the giant virus MutS7 specifically binds to branched DNA structures with single-stranded regions	3
Contents of Previous 3 Special Issues in this Series of Perspectives	3
Efficient activity of uracil DNA glycosylase (UNG2) in proliferating cells requires binding to proliferating cell nuclear antigen (PCNA) and replication protein A (RPA)	3
The multifaceted functions of homologous recombination in dealing with replication-associated DNA damages	3
Replication stress drives chromosomal instability in fibroblasts of childhood cancer survivors with second primary neoplasms	3
Imaging the cellular response to an antigen tagged interstrand crosslinking agent	3
The impact of chromatin on double-strand break repair: Imaging tools and discoveries	3
The model moss Physcomitrium patens relies heavily on homologous recombination to repair DNA double-strand breaks	3
The DHX9 helicase interacts with human DNA polymerase δ4 and stimulates its activity in D-loop extension synthesis	3
Exploring factors influencing choice of DNA double-strand break repair pathways	3
Mechanisms of tandem duplication in the cancer genome	3
Multi-scale cellular imaging of DNA double strand break repair	3
Polymorphic variant Asp239Tyr of human DNA glycosylase NTHL1 is inactive for removal of a variety of oxidatively-induced DNA base lesions from genomic DNA	3
Evidence that DNA polymerase δ proofreads errors made by DNA polymerase α across the Saccharomyces cerevisiae nuclear genome	3
Rtt107 cooperates with Rad55 to limit specific types of genome instability in Saccharomyces cerevisiae	3
Regulation, functional impact, and therapeutic targeting of APOBEC3A in cancer	3
PARP enzyme synthesis of protein-free poly(ADP-ribose): Implications for DNA damage signaling and repair	3
Ku80 is indispensable for repairing DNA double-strand breaks at highly methylated sites in human HCT116 cells	3
Methylation and hydroxymethylation of cytosine alter activity and fidelity of translesion DNA polymerases	3
Cloning and characterization of the major AP endonuclease from Staphylococcus aureus	3
The effect of methylation and hydroxymethylation of cytosine on activity and fidelity of Pol λ and Pol β	3
Super-resolution GSDIM microscopy unveils distinct nanoscale characteristics of DNA repair foci under diverse genotoxic stress	3
UBE2C promotes cell cycle progression and suppresses DNA damage-induced apoptosis in triple-negative breast cancer	3
Divergent structures of Mammalian and gammaherpesvirus uracil DNA glycosylases confer distinct DNA binding and substrate activity	3
The HPF1-dependent histone PARylation catalyzed by PARP2 is specifically stimulated by an incised AP site-containing BER DNA intermediate	3
Role of HSP40 proteins in genome maintenance, insulin signaling and cancer therapy	3
Editorial Board	3
Initiation of base excision repair is modulated by nucleosome occupancy modifying sequences	3
The dual role of DNA repair protein MGMT in cancer prevention and treatment	3
Mechanistic insights into RAD51-mediated nucleosome binding and remodeling in homologous recombination	3