DNA Repair

Article	Citations
Functional defects of cancer-associated MDC1 mutations in DNA damage repair	90
Spatial mapping of the DNA adducts in cancer	81
Regulatory apoptotic fragment of PARP1 complements catalytic fragment for PAR and DNA-dependent activity but inhibits DNA-induced catalytic stimulation of PARP2	81
Active genome integrity	51
Suppressors of Blm-deficiency identify three novel proteins that facilitate DNA repair in Ustilago maydis	46
Building an integrated view of R-loops, transcription, and chromatin	42
Loss of an ABC transporter in Arabidopsis thaliana confers hypersensitivity to the anti-cancer drug bleomycin	39
DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining	39
Editorial Board	39
Editors’ note Penny Jeggo and Bennett Van Houten	37
The burden of overweight: Higher body mass index, but not vital exhaustion, is associated with higher DNA damage and lower DNA repair capacity	36
Harnessing R-loop dynamics: Challenging cancer therapy resistance	34
From cooperation to conflicts – A complicated relationship between transcription and replication	34
Acetylation of H3K56 orchestrates UV-responsive chromatin events that generate DNA accessibility during Nucleotide Excision Repair	31
The role of human PrimPol active site residue Gln48 in catalysis and complex formation with DNA	31
Single-molecule approaches for DNA damage detection and repair: A focus on Repair Assisted Damage Detection (RADD)	29
PARP1-PROTACs providing novel opportunities in precision oncology by targeting DNA damage response	28
Single-molecule imaging of genome maintenance proteins encountering specific DNA sequences and structures	28
Stressed? Break-induced replication comes to the rescue!	28
A novel Family V uracil DNA glycosylase from Sulfolobus islandicus REY15A	27
Editorial Board	26
Irc20 modulates LOH frequency and distribution in S. cerevisiae	26
Editorial Board	26
Editorial Board	25
Comparing Mfd- and UvrD-dependent models of transcription coupled DNA repair in live Escherichia coli using single-molecule tracking	23

rumAB genes from SXT/R391 ICEs confer UV-induced mutability to Proteus mirabilis hosts and improve conjugation after UV irradiation	22
Positioning loss of PARP1 activity as the central toxic event in BRCA-deficient cancer	22
DNA damage response and genomic instability disorder: Meeting report of the 20th Ataxia-Telangiectasia Workshop (ATW-2024) in conjunction with the 15th international symposium on DNA damage response &	21
PARP inhibitors in ovarian cancer: Mechanisms of resistance and implications to therapy	21
Targeting base excision repair in precision oncology	20
The B cell dilemma: Diversity or fidelity?	20
DNA repair-related heritable photosensitivity syndromes: Mutation landscape in a multiethnic cohort of 17 multigenerational families with high degree of consanguinity	19
Corruption of DNA end-joining in mammalian chromosomes by progerin expression	19
The role of SLFN11 in DNA replication stress response and its implications for the Fanconi anemia pathway	19
What are the DNA lesions underlying formaldehyde toxicity?	19
Editorial Board	19
Chromatin meets the cytoskeleton: the importance of nuclear actin dynamics and associated motors for genome stability	19
Protein-protein interactions in the core nucleotide excision repair pathway	18
The differential roles of rad9 alternatively spliced forms in double- strand DNA break repair during Drosophila meiosis	18
DNA synthesis across DNA hairpins by human PrimPol	18
Phospho-SIM and exon8b of PML protein regulate formation of doxorubicin-induced rDNA-PML compartment	18
Double-strand break repair and mis-repair in 3D	17
The dark side of homology-directed repair	17
The interferon response at the intersection of genome integrity and innate immunity	16
Metazoan nuclear pore complexes in gene regulation and genome stability	16
Long-range PCR as a tool for evaluating mitochondrial DNA damage: Principles, benefits, and limitations of the technique	15
Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory	15
Editorial Board	15
NBS1 binds directly to TOPBP1 via disparate interactions between the NBS1 BRCT1 domain and the TOPBP1 BRCT1 and BRCT2 domains	15
Expression of BRCA1, BRCA2, RAD51, and other DSB repair factors is regulated by CRL4WDR70	14
Chromosomal single-strand break repair and neurological disease: Implications on transcription and emerging genomic tools	14
One-ended and two-ended breaks at nickase-broken replication forks	14
The multifaceted roles of the Ctf4 replisome hub in the maintenance of genome integrity	14
Sequence context effects of replication of Fapy•dG in three mutational hot spot sequences of the p53 gene in human cells	14
XPA is susceptible to proteolytic cleavage by cathepsin L during lysis of quiescent cells	14
Camptothecin compromises transcription recovery and cell survival against cisplatin and ultraviolet irradiation regardless of transcription-coupled nucleotide excision repair	14
Mutagenic repair of a ZFN-induced double-strand break in yeast: Effects of cleavage site sequence and spacer size	14
Centromere: A Trojan horse for genome stability	14
Variation in G-quadruplex sequence and topology differentially impacts human DNA polymerase fidelity	14
Endogenous base damage as a driver of genomic instability in homologous recombination-deficient cancers	13
Somatic mutation patterns at Ig and Non-Ig Loci	13
Cutting Edge Perspectives in genome maintenance X	13
Recent advances in γH2AX biomarker-based genotoxicity assays: A marker of DNA damage and repair	13
Using the safety scissors: DNA resection regulation at DNA double-strand breaks and telomeres	13
Impairment of the non-catalytic subunit Dpb2 of DNA Pol ɛ results in increased involvement of Pol δ on the leading strand	13
Large dataset of octocoral mitochondrial genomes provides new insights into mt-mutS evolution and function	13
Yearly perspective from the Co-Editors in Chief	13
DNA polymerase delta Exo domain stabilizes mononucleotide microsatellites in human cells	13
Altered pathways in Cockayne syndrome: Involvement of MAPK, PI3K-Akt, extracellular matrix, inflammation, and neuronal signaling	12
Biochemical characterization and mutational analysis of a mismatch glycosylase from the hyperthermophilic euryarchaeon Thermococcus barophilus Ch5	12
Inhibition of human DNA alkylation damage repair enzyme ALKBH2 by HIV protease inhibitor ritonavir	11
MicroRNAs and the DNA damage response: How is cell fate determined?	11
TOPBP1 regulates resistance of gastric cancer to oxaliplatin by promoting transcription of PARP1	11
miR-197-5p increases Doxorubicin-mediated anticancer cytotoxicity of HT1080 fibrosarcoma cells by decreasing drug efflux	11
Weaponizing CRISPR/Cas9 for selective elimination of cells with an aberrant genome	11

miR-185–5p rewires cisplatin resistance by restoring miR-203a-3p expression via downregulation of SOX9	11
Increased contribution of DNA polymerase delta to the leading strand replication in yeast with an impaired CMG helicase complex	11
Corrigendum to “Role of NEIL1 in genome maintenance” [DNA Repair 148 (2025) 103820]	10
Reversible association of ubiquitin with PCNA is important for template switching in S. cerevisiae	10
Editorial Board	10
BRCA1 and BRCA2 in DNA damage and replication stress response: Insights into their functions, mechanisms, and implications for cancer treatment	10
Editorial Board	10
Mechanisms and regulation of replication fork reversal	10
Frailty, sex, and poverty are associated with DNA damage and repair in frail, middle-aged urban adults	10
TFIIH central activity in nucleotide excision repair to prevent disease	10
Contents of previous 3 special issues in this series of perspectives	10
Impact of DNA sequences on DNA ‘opening’ by the Rad4/XPC nucleotide excision repair complex	9
Multi-omic analysis of altered transcriptome and epigenetic signatures in the UV-induced DNA damage response	9
Presenilin-1, mutated in familial Alzheimer’s disease, maintains genome stability via a γ-secretase dependent way	9
RNF4 prevents genomic instability caused by chronic DNA under-replication	9
Small-molecule activator of SMUG1 enhances repair of pyrimidine lesions in DNA	9
A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein	9
Insight into meiotic DNA end resection: Mechanisms and regulation	9
Genetic polymorphisms in DNA repair genes and hepatocellular carcinoma risk	9
CometChip enables parallel analysis of multiple DNA repair activities	9
C-terminal residues of DNA polymerase β and E3 ligase required for ubiquitin-linked proteolysis of oxidative DNA-protein crosslinks	9
Remdesivir triphosphate is a valid substrate to initiate synthesis of DNA primers by human PrimPol	8
Probing the structure and function of polymerase θ helicase-like domain	8
Incorporation of 5’,8-cyclo-2’deoxyadenosines by DNA repair polymerases via base excision repair	8
Regulation of DNA damage-induced HLA class I presentation	8
Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhances alkylating agent and PARG inhibition induced cytotoxicity	8
Therapeutic targeting of mismatch repair proteins in triplet repeat expansion diseases	8
Determination of DNA lesion bypass using a ChIP-based assay	8
Processes shaping cancer genomes – From mitotic defects to chromosomal rearrangements	8
Obituary	8
The flap endonuclease-1 mediated maturation of Okazaki fragments is critical for the cellular tolerance to remdesivir	8
KBM-mediated interactions with KU80 promote cellular resistance to DNA replication stress in CHO cells	8
Mlh1 interacts with both Msh2 and Msh6 for recruitment during mismatch repair	8
Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1	8
Real-time single-molecule visualization using DNA curtains reveals the molecular mechanisms underlying DNA repair pathways	7
Cutting edge perspectives in genome maintenance XI	7
USP1 in regulation of DNA repair pathways	7
SMC-5/6 complex subunit NSE-1 plays a crucial role in meiosis and DNA repair in Caenorhabditis elegans	7
DNA lesions that block transcription induce the death of Trypanosoma cruzi via ATR activation, which is dependent on the presence of R-loops	7
Screening of glycosylase activity on oxidative derivatives of methylcytosine: Pedobacter heparinus SMUG2 as a formylcytosine- and carboxylcytosine-DNA glycosylase	7
Variants in the first methionine of RAD51C are homologous recombination proficient due to an alternative start site	7
Editorial Board	7
DONSON: Slding in 2 the limelight	7
Genome integrity and inflammation in the nervous system	7
Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates	7
Low and high doses of ionizing radiation evoke discrete global (phospho)proteome responses	7
Mouse Embryonic Fibroblasts Isolated From Nthl1 D227Y Knockin Mice Exhibit Defective DNA Repair and Increased Genome Instability	7
Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication	7
Corrigendum to “Quantitative assessment of HR and NHEJ activities via CRISPR/Cas9-induced oligodeoxynucleotide-mediated DSB repair” [DNA Repair 70 (2018) 67–71]	7
Biochemical characterization and mutational studies of endonuclease Q from the hyperthermophilic euryarchaeon Thermococcus gammatolerans	7
The replication stress response: Mechanisms and functions	7
Discovery of KPT-6566 as STAG1/2 Inhibitor sensitizing PARP and NHEJ Inhibitors to suppress tumor cells growth in vitro	6
Emerging connections: Poly(ADP-ribose), FET proteins and RNA in the regulation of DNA damage condensates	6
The mRNA tether model for activation-induced deaminase and its relevance for Ig somatic hypermutation and class switch recombination	6
Editorial Board	6
Errol Friedberg: A life in writing	6
Structure, function and evolution of the HerA subfamily proteins	6
XRCC3 loss leads to midgestational embryonic lethality in mice	6
Compartmentalization of the DNA damage response: Mechanisms and functions	6
Phylogenetic distribution, structural analysis and interaction of nucleotide excision repair proteins in cyanobacteria	6
Role of the multifunctional transcription factor TFII-I in DNA damage repair	6
Single-molecule studies of helicases and translocases in prokaryotic genome-maintenance pathways	6
Editorial Board	6
The biochemistry of the carcinogenic alcohol metabolite acetaldehyde	6
Why the ROS matters: One-electron oxidants focus DNA damage and repair on G-quadruplexes for gene regulation	6
PARPs and ADP-ribosyl hydrolases in cancer therapy: From drug targets to biomarkers	6
Significance and limitations of the use of next-generation sequencing technologies for detecting mutational signatures	6
LncRNA LINC01664 promotes cancer resistance through facilitating homologous recombination-mediated DNA repair	6
Editorial Board	6
The Sm core components of small nuclear ribonucleoproteins promote homologous recombination repair	6
Structure and mechanism in non-homologous end joining	5
Temporal and spatial dynamics of DNA double-strand break repair centers	5
Holding it together: DNA end synapsis during non-homologous end joining	5
APE1 is a master regulator of the ATR-/ATM-mediated DNA damage response	5
The role of histone H3K36me3 writers, readers and erasers in maintaining genome stability	5
Reversal of histone H2B mono-ubiquitination is required for replication stress recovery	5
DNA damage repair (DDR) related prognostic risk model in multiple myeloma based on single-cell and bulk sequencing	5
Multiple functions of PARP1 in the repair of DNA double strand breaks	5
Live cell single-molecule imaging to study DNA repair in human cells	5
S-palmitoylation: An oily modification guardinggenome stability	5

Deletions initiated by the vaccinia virus TopIB protein in yeast	5
Transcription coupled base excision repair in mammalian cells: So little is known and so much to uncover	5
DNA Repair Capacity for Personalizing Risk and Treatment Response − Assay Development and Optimization in Human Peripheral Blood Mononuclear Cells (PBMCs)	5
The fast-growing business of Serine ADP-ribosylation	5
From rest to repair: Safeguarding genomic integrity in quiescent cells	5
Repair of genomic interstrand crosslinks	5
Targeting Wee1 kinase as a therapeutic approach in Hematological Malignancies	5
Replication initiation sites and zones in the mammalian genome: Where are they located and how are they defined?	5
DNA polymerase δ: A single Pol31 polymorphism suppresses the strain background-specific lethality of Pol32 inactivation in Saccharomyces cerevisiae	4
The nucleotide excision repair proteins through the lens of molecular dynamics simulations	4
Mechanism for R-loop formation remote from the transcription start site: Topological issues and possible facilitation by dissociation of RNA polymerase	4
Histone lysine modifying enzymes and their critical roles in DNA double-strand break repair	4
FBH1 and the replication stress response: Implications for genome stability and cancer development	4
Bulk synthesis and beyond: The roles of eukaryotic replicative DNA polymerases	4
Multifunctional properties of Nej1XLF C-terminus promote end-joining and impact DNA double-strand break repair pathway choice	4
The roles of non-productive complexes of DNA repair proteins with DNA lesions	4
UVSSA facilitates transcription-coupled repair of DNA interstrand crosslinks	4
Histone and Chromatin Dynamics Facilitating DNA repair	4
BCLAF1, a functional partner of BACH1, participates in DNA damage response	4
To divide or not to divide? NAC8 (SOG1) as a key regulator of DNA damage response in barley (Hordeum vulgare L.)	4
Toxic R-loops: Cause or consequence of replication stress?	4
Cockayne syndrome group B protein uses its DNA translocase activity to promote mitotic DNA synthesis	4
Global screening of base excision repair in nucleosome core particles	4
Targeting DNA damage sensors for cancer therapy	4
Interaction of mitoxantrone with abasic sites - DNA strand cleavage and inhibition of apurinic/apyrimidinic endonuclease 1, APE1	4
The C-terminal tail of Rad17, iVERGE, binds the 9‒1‒1 complex independently of AAA+ ATPase domains to provide another clamp–loader interface	4
Transcription-coupled DNA double-strand break repair	4
DNA damage-induced sumoylation of Sp1 induces its interaction with RNF4 and degradation in S phase to remove 53BP1 from DSBs and permit HR	4
Editorial Board	4
A-T neurodegeneration and DNA damage-induced transcriptional stress	4
C. elegans ribosomal protein S3 protects against H2O2-induced DNA damage and suppresses spontaneous mutations in yeast	4
Phosphoregulation of the checkpoint kinase Mec1ATR	4
Editorial Board	4
Non-canonical function of nuclear PTEN and its implication on tumorigenesis	4
Kinome-wide screening uncovers a role for Bromodomain Protein 3 in DNA double-stranded break repair	4
Determinants governing BRC function evaluated by mutational analysis of Brh2 in Ustilago maydis	4
DNA repair pathways in the mitochondria	4
Editorial Board	4
Monitoring DNA polymerase β mitochondrial localization and dynamics	4
DNA topoisomerase IIß inhibition blocks DNA end resection and synergizes with PARPi in BRCA1-deficient models	3
Lawrence H. Thompson: A life of bikes, birds, and DNA repair (1941–2024)	3
The C-terminal domain of Arabidopsis ROS1 DNA demethylase interacts with histone H3 and is required for DNA binding and catalytic activity	3
O-GlcNAc transferase is important for homology-directed repair	3
Histone variants: The unsung guardians of the genome	3
Live cell transcription-coupled nucleotide excision repair dynamics revisited	3
The analysis of protein recruitment to laser microirradiation-induced DNA damage in live cells: Best practices for data analysis	3
SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice	3
Genomic stress and impaired DNA repair in Alzheimer disease	3
Editorial	3
Unveiling cGAS mechanisms: Insights into DNA damage and immune sensing in cancer	3
Cancer testis antigens and genomic instability: More than immunology	3
Temporal recruitment of base excision DNA repair factors in living cells in response to different micro-irradiation DNA damage protocols	3
The DNA damage induced immune response: Implications for cancer therapy	3
‘From R-lupus to cancer’: Reviewing the role of R-loops in innate immune responses	3
53BP1-the ‘Pandora’s box’ of genome integrity	3
Partial deletions of the autoregulatory C-terminal domain of Artemis and their effect on its nuclease activity	3
Joining of DNA breaks- interplay between DNA ligases and poly (ADP-ribose) polymerases	3
Functions of PMS2 and MLH1 important for regulation of divergent repeat-mediated deletions	3
Compared to other NHEJ factors, DNA-PK protein and RNA levels are markedly increased in all higher primates, but not in prosimians or other mammals	3
DNA repair deficiencies and neurodegeneration	3
Rrp1, Rrp2 and Uls1 – Yeast SWI2/SNF2 DNA dependent translocases in genome stability maintenance	3
UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1	3
Single-molecule toxicogenomics: Optical genome mapping of DNA-damage in nanochannel arrays	3
Evolution of the triplet BRCT domain	3
Overexpression of the WWE domain of RNF146 modulates poly-(ADP)-ribose dynamics at sites of DNA damage	3
Biochemical analysis of H2O2-induced mutation spectra revealed that multiple damages were involved in the mutational process	3
FAM21 interacts with Ku to promote the localization of WASH to DNA double strand break sites	3
Cutting-edge perspectives in genomic maintenance VIII	3
Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes	3
The Ataxia-telangiectasia mutated (ATM) is the most important gene for repairing the DNA in Myelodysplastic Neoplasm	3
Microglial inflammation in genome instability: A neurodegenerative perspective	3
Mediator complex in transcription regulation and DNA repair: Relevance for human diseases	3
Structure, function and evolution of the Helix-hairpin-Helix DNA glycosylase superfamily: Piecing together the evolutionary puzzle of DNA base damage repair mechanisms	3
The effect of methylation and hydroxymethylation of cytosine on activity and fidelity of Pol λ and Pol β	2
Divergent structures of Mammalian and gammaherpesvirus uracil DNA glycosylases confer distinct DNA binding and substrate activity	2
Role of the nucleotide excision repair pathway proteins (UvrB and UvrD2) in recycling UdgB, a base excision repair enzyme in Mycobacterium smegmatis	2
Editors’ note on “p21CDKN1A participates in base excision repair by regulating the activity of poly(ADP-ribose) polymerase-1”	2
How RNA impacts DNA repair	2
The model moss Physcomitrium patens relies heavily on homologous recombination to repair DNA double-strand breaks	2
Imaging the cellular response to an antigen tagged interstrand crosslinking agent	2
DNA damage response inhibitors in cancer therapy: Mechanisms, clinical development, and combination strategies	2
Methylation and hydroxymethylation of cytosine alter activity and fidelity of translesion DNA polymerases	2
Role of HSP40 proteins in genome maintenance, insulin signaling and cancer therapy	2
Checkpoint activation and recovery: regulation of the 9–1–1 axis by the PP2A phosphatase	2
Mechanisms of tandem duplication in the cancer genome	2
Genome organization and stability in mammalian pre-implantation development	2
Differential ETS1 binding to T:G mismatches within a CpG dinucleotide contributes to C-to-T somatic mutation rate of the IDH2 hotspot at codon Arg140	2
Super-resolution GSDIM microscopy unveils distinct nanoscale characteristics of DNA repair foci under diverse genotoxic stress	2
Exploring factors influencing choice of DNA double-strand break repair pathways	2
The interactions between DNA methylation machinery and long non-coding RNAs in tumor progression and drug resistance	2
Post-translational regulation of Tyrosyl-DNA phosphodiesterase (TDP1 and TDP2) for the repair of the trapped topoisomerase-DNA covalent complex	2
Multi-scale cellular imaging of DNA double strand break repair	2
Polymorphic variant Asp239Tyr of human DNA glycosylase NTHL1 is inactive for removal of a variety of oxidatively-induced DNA base lesions from genomic DNA	2
The DHX9 helicase interacts with human DNA polymerase δ4 and stimulates its activity in D-loop extension synthesis	2
A redox-sensitive iron-sulfur cluster in murine FAM72A controls its ability to degrade the nuclear form of uracil-DNA glycosylase	2