DNA Repair

Article	Citations
Synergistic effects on mutagenicity of tandem lesions containing 8-oxo-7,8-dihydro-2′-deoxyguanosine or Fapy•dG flanked by a 3′ 5-formyl-2′-deoxyuridine in human cells	68
Frailty, sex, and poverty are associated with DNA damage and repair in frail, middle-aged urban adults	63
Editorial Board	63
Human translesion DNA polymerases ι and κ mediate tolerance to temozolomide in MGMT-deficient glioblastoma cells.	62
The nucleotide excision repair proteins through the lens of molecular dynamics simulations	39
Suppressors of Blm-deficiency identify three novel proteins that facilitate DNA repair in Ustilago maydis	37
Catalytic activity of OGG1 is impaired by Zinc deficiency	34
Mitochondrial apurinic/apyrimidinic endonuclease Apn1 is not critical for the completion of the Plasmodium berghei life cycle	33
Structural features of DNA polymerases β and λ in complex with benzo[a]pyrene-adducted DNA cause a difference in lesion tolerance	33
The role of DNA damage response in chemo- and radio-resistance of cancer cells: Can DDR inhibitors sole the problem?	31
Editorial Board	29
DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining	28
Editorial Board	26
Chemopotentiating effects of low-dose fractionated radiation on cisplatin and paclitaxel in cervix cancer cell lines and normal fibroblasts from patients with cervix cancer	25
The life and legacy of Sam Wilson (1939–2021)	25
Loss of an ABC transporter in Arabidopsis thaliana confers hypersensitivity to the anti-cancer drug bleomycin	25
Species variations in XRCC1 recruitment strategies for FHA domain-containing proteins	24
USP13 regulates the replication stress response by deubiquitinating TopBP1	24
Heterogeneity of DNA damage incidence and repair in different chromatin contexts	24
Editorial Board	23
Mechanism for R-loop formation remote from the transcription start site: Topological issues and possible facilitation by dissociation of RNA polymerase	23
Editorial Board	23
Transcription and genome integrity	22
From fluorescent foci to sequence: Illuminating DNA double strand break repair by high-throughput sequencing technologies	21
UV light-induced dual promoter mutations dismantle the telomeric guardrails in melanoma	21

Editorial Board	21
Cutting-edge Perspectives in Genome Maintenance IX	21
Regulatory apoptotic fragment of PARP1 complements catalytic fragment for PAR and DNA-dependent activity but inhibits DNA-induced catalytic stimulation of PARP2	20
Editors’ Note	20
Editorial Board	19
DNA polymerase δ: A single Pol31 polymorphism suppresses the strain background-specific lethality of Pol32 inactivation in Saccharomyces cerevisiae	19
Editorial Board	18
A novel role for Mms2 in the control of spontaneous mutagenesis and Pol3 abundance	17
C. elegans ribosomal protein S3 protects against H2O2-induced DNA damage and suppresses spontaneous mutations in yeast	17
Editorial Board	17
The ataxia-telangiectasia mutated gene product regulates the cellular acid-labile sulfide fraction	17
The RNF8 and RNF168 Ubiquitin Ligases Regulate Pro- and Anti-Resection Activities at Broken DNA Ends During Non-Homologous End Joining	17
Cockayne syndrome group B protein uses its DNA translocase activity to promote mitotic DNA synthesis	17
How DNA damage and non-canonical nucleotides alter the telomerase catalytic cycle	17
Toxic R-loops: Cause or consequence of replication stress?	16
Revisiting the BRCA-pathway through the lens of replication gap suppression	16
Functional defects of cancer-associated MDC1 mutations in DNA damage repair	16
MicroRNAs and the DNA damage response: How is cell fate determined?	16
PARP1-mediated PARylation of TonEBP prevents R-loop–associated DNA damage	15
Cdc48/p97 segregase: Spotlight on DNA-protein crosslinks	15
NEIL3: A unique DNA glycosylase involved in interstrand DNA crosslink repair	15
Histone variants H3.3 and H2A.Z/H3.3 facilitate excision of uracil from nucleosome core particles	15
Increased contribution of DNA polymerase delta to the leading strand replication in yeast with an impaired CMG helicase complex	15
The Eyes Absent family: At the intersection of DNA repair, mitosis, and replication	14
Cyclin-dependent kinase inhibitors (CDKIs) and the DNA damage response: The link between signaling pathways and cancer	14
The role of rRNA in maintaining genome stability	14
Histone and Chromatin Dynamics Facilitating DNA repair	14
Defects in DNA damage responses in SWI/SNF mutant cells and their impact on immune responses	14
Timely upstream events regulating nucleotide excision repair by ubiquitin-proteasome system: ubiquitin guides the way	14
Spatial mapping of the DNA adducts in cancer	14
DNA damage response and breast cancer development: Possible therapeutic applications of ATR, ATM, PARP, BRCA1 inhibition	14
Transcription reprogramming and endogenous DNA damage	13
Helicase activities of Rad5 and Rrm3 genetically interact in the prevention of recombinogenic DNA lesions in Saccharomyces cerevisiae	13
Mechanistic insights from high resolution DNA damage analysis to understand mixed radiation exposure	13
The FAcilitates Chromatin Transcription (FACT) complex: Its roles in DNA repair and implications for cancer therapy	13
BCLAF1, a functional partner of BACH1, participates in DNA damage response	13
A-T neurodegeneration and DNA damage-induced transcriptional stress	12
Impacts of chromatin dynamics and compartmentalization on DNA repair	12
Mechanisms of genome stability maintenance during cell division	12
The multifaceted roles of DNA repair and replication proteins in aging and obesity	12
To divide or not to divide? NAC8 (SOG1) as a key regulator of DNA Damage Response in barley (Hordeum vulgare L.)	12
PARP1: Structural insights and pharmacological targets for inhibition	12
Divergent structures of Mammalian and gammaherpesvirus uracil DNA glycosylases confer distinct DNA binding and substrate activity	11
Impact of DNA sequences on DNA ‘opening’ by the Rad4/XPC nucleotide excision repair complex	11
Novel insights into bulky DNA damage formation and nucleotide excision repair from high-resolution genomics	11
Live cell transcription-coupled nucleotide excision repair dynamics revisited	11
DNA-PK: A synopsis beyond synapsis	11
Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes	11
Potential cGAS-STING pathway functions in DNA damage responses, DNA replication and DNA repair	11
Plasmodium Ape1 is a multifunctional enzyme in mitochondrial base excision repair and is required for efficient transition from liver to blood stage infection	11

Bulk synthesis and beyond: The roles of eukaryotic replicative DNA polymerases	11
Editorial Board	11
Histone lysine modifying enzymes and their critical roles in DNA double-strand break repair	10
Tolerating DNA damage by repriming: Gap filling in the spotlight	10
Single-molecule approaches for DNA damage detection and repair: A focus on Repair Assisted Damage Detection (RADD)	10
Replication dependent and independent mechanisms of GAA repeat instability	10
Hydroxychloroquine induces oxidative DNA damage and mutation in mammalian cells	10
Chaperoning histones at the DNA repair dance	10
Fanconi anemia and Aldehyde Degradation Deficiency Syndrome: Metabolism and DNA repair protect the genome and hematopoiesis from endogenous DNA damage	10
Modulation of immune responses by DNA damage signaling	10
Monitoring DNA polymerase β mitochondrial localization and dynamics	9
The roles of TonEBP in the DNA damage response: From DNA damage bypass to R-loop resolution	9
CST in maintaining genome stability: Beyond telomeres	9
DNA repair gene polymorphisms and chromosomal aberrations in healthy, nonsmoking population	9
The analysis of protein recruitment to laser microirradiation-induced DNA damage in live cells: Best practices for data analysis	9
Mechanisms and regulation of replication fork reversal	9
The interactions between DNA methylation machinery and long non-coding RNAs in tumor progression and drug resistance	9
Phosphoregulation of the checkpoint kinase Mec1ATR	9
The cross-talk between signaling pathways, noncoding RNAs and DNA damage response: Emerging players in cancer progression	9
Editorial Board	8
Impaired DNA repair in mouse monocytes compared to macrophages and precursors	8
Editors’ note on “p21CDKN1A participates in base excision repair by regulating the activity of poly(ADP-ribose) polymerase-1”	8
Editorial Board	8
Contents of previous 3 special issues in this series of perspectives	8
Editorial Board	8
Editorial Board	8
Acetylation of H3K56 orchestrates UV-responsive chromatin events that generate DNA accessibility during Nucleotide Excision Repair	8
Kinome-wide screening uncovers a role for Bromodomain Protein 3 in DNA double-stranded break repair	8
Presenilin-1, mutated in familial Alzheimer’s disease, maintains genome stability via a γ-secretase dependent way	8
RNF4 prevents genomic instability caused by chronic DNA under-replication	8
Genetic polymorphisms in DNA repair genes and hepatocellular carcinoma risk	8
Editorial Board	8
Editorial Board	8
UvrD-like helicase Hmi1 Has an ATP independent role in yeast mitochondrial DNA maintenance	8
Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhances alkylating agent and PARG inhibition induced cytotoxicity	7
Exploring factors influencing choice of DNA double-strand break repair pathways	7
Contents of previous 3 special issues in this series of perspectives	7
Finding significance: New perspectives in variant classification of the RAD51 regulators, BRCA2 and beyond	7
HOTAIR beyond repression: In protein degradation, inflammation, DNA damage response, and cell signaling	7
Editorial Board	7
The C-terminal tail of Rad17, iVERGE, binds the 9‒1‒1 complex independently of AAA+ ATPase domains to provide another clamp–loader interface	7
Multifunctional properties of Nej1XLF C-terminus promote end-joining and impact DNA double-strand break repair pathway choice	7
Editorial Board	7
The burden of overweight: Higher body mass index, but not vital exhaustion, is associated with higher DNA damage and lower DNA repair capacity	6
TFIIH central activity in nucleotide excision repair to prevent disease	6
A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein	6
Paradoxical role of the major DNA repair protein, OGG1, in action-at-a-distance mutation induction by 8-oxo-7,8-dihydroguanine	6
C-terminal residues of DNA polymerase β and E3 ligase required for ubiquitin-linked proteolysis of oxidative DNA-protein crosslinks	6
RNA helicase, DDX3X, is actively recruited to sites of DNA damage in live cells	6
Single-molecule imaging of genome maintenance proteins encountering specific DNA sequences and structures	6
DNA damage-induced sumoylation of Sp1 induces its interaction with RNF4 and degradation in S phase to remove 53BP1 from DSBs and permit HR	6
DEF1: Much more than an RNA polymerase degradation factor	6
An open-source platform to quantify subnuclear foci and protein colocalization in response to replication stress	6
Stressed? Break-induced replication comes to the rescue!	6
Multi-scale cellular imaging of DNA double strand break repair	6
Dominant roles of BRCA1 in cellular tolerance to a chain-terminating nucleoside analog, alovudine	6
The N-terminal domain of uracil-DNA glycosylase: Roles for disordered regions	6
Coping with RNA damage with a focus on APE1, a BER enzyme at the crossroad between DNA damage repair and RNA processing/decay	6
UVSSA facilitates transcription-coupled repair of DNA interstrand crosslinks	6
Non-canonical function of nuclear PTEN and its implication on tumorigenesis	6
The HPF1-dependent histone PARylation catalyzed by PARP2 is specifically stimulated by an incised AP site-containing BER DNA intermediate	5
Interaction of Wwox with Brca1 and associated complex proteins prevents premature resection at double-strand breaks and aberrant homologous recombination	5
Single-molecule analysis of purified proteins and nuclear extracts: Insights from 8-oxoguanine glycosylase 1	5
Processes shaping cancer genomes – From mitotic defects to chromosomal rearrangements	5
Global screening of base excision repair in nucleosome core particles	5
CometChip enables parallel analysis of multiple DNA repair activities	5
The Shu complex is an ATPase that regulates Rad51 filaments during homologous recombination in the DNA damage response	5
Mechanisms of tandem duplication in the cancer genome	5
Functional characterization of single nucleotide polymorphic variants of DNA repair enzyme NEIL1 in South Asian populations	5
Kinetics model of DNA double-strand break repair in eukaryotes	5
Mlh1 interacts with both Msh2 and Msh6 for recruitment during mismatch repair	5
DNA Repair Pathways in the Mitochondria	5
Transient HR enhancement by RAD51-stimulatory compound confers protection on intestinal rather than hematopoietic tissue against irradiation in mice	5
Small-molecule activator of SMUG1 enhances repair of pyrimidine lesions in DNA	5
Functions of PMS2 and MLH1 important for regulation of divergent repeat-mediated deletions	5
Recognition and removal of clustered DNA lesions via nucleotide excision repair	5
DNA-PK inhibitor AZD7648 is a more portent radiosensitizer than PARP inhibitor Olaparib in BRCA1/2 deficient tumors	5
FAM21 interacts with Ku to promote the localization of WASH to DNA double strand break sites	5
FANCM branchpoint translocase: Master of traverse, reverse and adverse DNA repair	5
The flap endonuclease-1 mediated maturation of Okazaki fragments is critical for the cellular tolerance to remdesivir	5

Multi-omic analysis of altered transcriptome and epigenetic signatures in the UV-induced DNA damage response	5
The Ataxia-telangiectasia mutated (ATM) is the most important gene for repairing the DNA in Myelodysplastic Neoplasm	5
Genomic stress and impaired DNA repair in Alzheimer disease	5
Compared to other NHEJ factors, DNA-PK protein and RNA levels are markedly increased in all higher primates, but not in prosimians or other mammals	4
The evolving complexity of DNA damage foci: RNA, condensates and chromatin in DNA double-strand break repair	4
Chromatin meets the cytoskeleton: the importance of nuclear actin dynamics and associated motors for genome stability	4
Targeted nuclear irradiation with a proton microbeam induces oxidative DNA base damage and triggers the recruitment of DNA glycosylases OGG1 and NTH1	4
Editorial Board	4
To indel or not to indel: Factors influencing mutagenesis during chromosomal break end joining	4
Understanding the DNA double-strand break repair and its therapeutic implications	4
Biochemical analysis of H2O2-induced mutation spectra revealed that multiple damages were involved in the mutational process	4
Microglial inflammation in genome instability: A neurodegenerative perspective	4
KBM-mediated interactions with KU80 promote cellular resistance to DNA replication stress in CHO cells	4
Irc20 modulates LOH frequency and distribution in S. cerevisiae	4
Remdesivir triphosphate is a valid substrate to initiate synthesis of DNA primers by human PrimPol	4
A non-canonical nucleotide from viral genomes interferes with the oxidative DNA damage repair system	4
How RNA impacts DNA repair	4
DNA mismatch repair controls the mutagenicity of Polymerase ζ-dependent translesion synthesis at methylated guanines	4
WITHDRAWN: Melatonin increases doxorubicin-induced apoptosis via oxidative DNA damage in oral squamous cell carcinoma	4
Editorial Board	4
SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice	4
Cell cycle-dependent radiosensitivity in mouse zygotes	4
Increased DNA repair capacity augments resistance of glioblastoma cells to photodynamic therapy	4
What are the DNA lesions underlying formaldehyde toxicity?	4
Corruption of DNA end-joining in mammalian chromosomes by progerin expression	4
Mediator complex in transcription regulation and DNA repair: Relevance for human diseases	4
O-GlcNAc transferase is important for homology-directed repair	4
DNA damage response and PD-1/PD-L1 pathway in ovarian cancer	4
Editorial Board	4
Super-resolution GSDIM microscopy unveils distinct nanoscale characteristics of DNA repair foci under diverse genotoxic stress	4
Defining R-loop classes and their contributions to genome instability	4
Obituary	3
DNA glycosylases for 8-oxoguanine repair in Staphylococcus aureus	3
Error-prone bypass patch by a low-fidelity variant of DNA polymerase zeta in human cells	3
Determination of DNA lesion bypass using a ChIP-based assay	3
rumAB genes from SXT/R391 ICEs confer UV-induced mutability to Proteus mirabilis hosts and improve conjugation after UV irradiation	3
A homogeneous fluorescence assay for rapid and sensitive quantification of the global level of abasic sites in genomic DNA	3
Editorial Board	3
Editorial Board	3
Targeting mitotic regulators in cancer as a strategy to enhance immune recognition	3
Shining light on single-strand lesions caused by the chemotherapy drug bleomycin	3
Incorporation of 5’,8-cyclo-2’deoxyadenosines by DNA repair polymerases via base excision repair	3
A novel Family V uracil DNA glycosylase from Sulfolobus islandicus REY15A	3
Cutting-edge perspectives in genomic maintenance VIII	3
‘From R-lupus to cancer’: Reviewing the role of R-loops in innate immune responses	3
Probing the structure and function of polymerase θ helicase-like domain	3
The DHX9 helicase interacts with human DNA polymerase δ4 and stimulates its activity in D-loop extension synthesis	3
Regulation of DNA damage-induced HLA class I presentation	3
Editorial Board	3
Editorial Board	3
Partial deletions of the autoregulatory C-terminal domain of Artemis and their effect on its nuclease activity	3
The DNA damage induced immune response: Implications for cancer therapy	3
Role of the nucleotide excision repair pathway proteins (UvrB and UvrD2) in recycling UdgB, a base excision repair enzyme in Mycobacterium smegmatis	3
Fluorescently labeled human apurinic/apyrimidinic endonuclease APE1 reveals effects of DNA polymerase β on the APE1–DNA interaction	3
Polymorphic variant Asp239Tyr of human DNA glycosylase NTHL1 is inactive for removal of a variety of oxidatively-induced DNA base lesions from genomic DNA	3
Comparing Mfd- and UvrD-dependent models of transcription coupled DNA repair in live Escherichia coli using single-molecule tracking	3
Chromatin dynamics and DNA replication roadblocks	2
The C-terminal domain of Arabidopsis ROS1 DNA demethylase interacts with histone H3 and is required for DNA binding and catalytic activity	2
Roles of phosphatases in eukaryotic DNA replication initiation control	2
USP1 in regulation of DNA repair pathways	2
53BP1-the ‘Pandora’s box’ of genome integrity	2
Histone variants: The unsung guardians of the genome	2
Post-translational modification of factors involved in homologous recombination	2
Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1	2
A redox-sensitive iron-sulfur cluster in murine FAM72A controls its ability to degrade the nuclear form of uracil-DNA glycosylase	2
Intersection of the fragile X-related disorders and the DNA damage response	2
An exchange of single amino acid between the phosphohydrolase modules of Escherichia coli MutT and Mycobacterium smegmatis MutT1 switches their cleavage specificities	2
Formation and repair of unavoidable, endogenous interstrand cross-links in cellular DNA	2
Low and high doses of ionizing radiation evoke discrete global (phospho)proteome responses	2
Transcription-coupled repair and the transcriptional response to UV-Irradiation	2
Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication	2
Signaling pathways involved in cell cycle arrest during the DNA breaks	2
DNA lesions that block transcription induce the death of Trypanosoma cruzi via ATR activation, which is dependent on the presence of R-loops	2
Positioning loss of PARP1 activity as the central toxic event in BRCA-deficient cancer	2
Methylation and hydroxymethylation of cytosine alter activity and fidelity of translesion DNA polymerases	2
Replication initiation: Implications in genome integrity	2
Differential ETS1 binding to T:G mismatches within a CpG dinucleotide contributes to C-to-T somatic mutation rate of the IDH2 hotspot at codon Arg140	2
Role of the multifunctional transcription factor TFII-I in DNA damage repair	2
The impact of chromatin on double-strand break repair: Imaging tools and discoveries	2
G-quadruplex resolution: From molecular mechanisms to physiological relevance	2
Phospho-SIM and exon8b of PML protein regulate formation of doxorubicin-induced rDNA-PML compartment	2
DONSON: Slding in 2 the limelight	2
DNA damage response and repair in osteosarcoma: Defects, regulation and therapeutic implications	2
The interplay between chromatin remodeling and DNA double-strand break repair: Implications for cancer biology and therapeutics	2
Genome organization and stability in mammalian pre-implantation development	2
The rate of formation and stability of abasic site interstrand crosslinks in the DNA duplex	2
Molecular dynamics simulations reveal how H3K56 acetylation impacts nucleosome structure to promote DNA exposure for lesion sensing	2
Effect of mismatch repair on the mutational footprint of the bacterial SOS mutator activity	2
Imaging the cellular response to an antigen tagged interstrand crosslinking agent	2
Role of histone acetyltransferases MOF and Tip60 in genome stability	2
Metazoan nuclear pore complexes in gene regulation and genome stability	2
SMC-5/6 complex subunit NSE-1 plays a crucial role in meiosis and DNA repair in Caenorhabditis elegans	2