DNA Repair

(The median citation count of DNA Repair is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)
New insights into abasic site repair and tolerance85
Cancer type-dependent correlations between TP53 mutations and antitumor immunity82
Excision repair of topoisomerase DNA-protein crosslinks (TOP-DPC)60
Roles for 53BP1 in the repair of radiation-induced DNA double strand breaks60
The MRE11 complex: A versatile toolkit for the repair of broken DNA58
Mammalian DNA base excision repair: Dancing in the moonlight56
Biomolecular condensates at sites of DNA damage: More than just a phase52
Defining R-loop classes and their contributions to genome instability49
Debulking of topoisomerase DNA-protein crosslinks (TOP-DPC) by the proteasome, non-proteasomal and non-proteolytic pathways48
ADP-ribosylation of DNA and RNA48
Recent advances in γH2AX biomarker-based genotoxicity assays: A marker of DNA damage and repair47
Molecular origins of APOBEC-associated mutations in cancer45
DNA mismatch repair-dependent DNA damage responses and cancer40
DNA-protein crosslink formation by endogenous aldehydes and AP sites37
Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair37
The recent advances in non-homologous end-joining through the lens of lymphocyte development36
The cerebellar degeneration in ataxia-telangiectasia: A case for genome instability34
PARP1: Structural insights and pharmacological targets for inhibition33
Towards DNA-damage induced autophagy: A Boolean model of p53-induced cell fate mechanisms33
Targeting Wee1 kinase as a therapeutic approach in Hematological Malignancies32
Towards a comprehensive view of 8-oxo-7,8-dihydro-2’-deoxyguanosine: Highlighting the intertwined roles of DNA damage and epigenetics in genomic instability32
Strand discrimination in DNA mismatch repair31
Consequences of compromised mitochondrial genome integrity30
How to fix DNA-protein crosslinks29
Coping with RNA damage with a focus on APE1, a BER enzyme at the crossroad between DNA damage repair and RNA processing/decay29
The role of the SWI/SNF chromatin remodelling complex in the response to DNA double strand breaks27
Time for remodeling: SNF2-family DNA translocases in replication fork metabolism and human disease26
Human DNA ligases in replication and repair26
Dealing with transcription-blocking DNA damage: Repair mechanisms, RNA polymerase II processing and human disorders25
The evolving complexity of DNA damage foci: RNA, condensates and chromatin in DNA double-strand break repair25
Role of mtDNA disturbances in the pathogenesis of Alzheimer’s and Parkinson’s disease25
TREX1 – Apex predator of cytosolic DNA metabolism25
XRCC1 – Strategies for coordinating and assembling a versatile DNA damage response25
PARPs’ impact on base excision DNA repair24
P53 in the impaired lungs24
Roles for MDC1 in cancer development and treatment24
Revisiting the BRCA-pathway through the lens of replication gap suppression24
DNA damage response and repair in osteosarcoma: Defects, regulation and therapeutic implications23
Hypermutation in single-stranded DNA23
Signaling pathways involved in cell cycle arrest during the DNA breaks23
The SNM1A DNA repair nuclease23
NAD+-mediated regulation of mammalian base excision repair22
EXO1: A tightly regulated nuclease22
Cellular response to endogenous DNA damage: DNA base modifications in gene expression regulation22
Transcription-coupled nucleotide excision repair: New insights revealed by genomic approaches22
NTHL1 in genomic integrity, aging and cancer21
Twenty years of t-loops: A case study for the importance of collaboration in molecular biology21
PRMT1 is critical to FEN1 expression and drug resistance in lung cancer cells21
Expanding molecular roles of UV-DDB: Shining light on genome stability and cancer21
DNA helicases and their roles in cancer20
Impact of circadian disruption on health; SIRT1 and Telomeres20
Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP120
Transcription coupled base excision repair in mammalian cells: So little is known and so much to uncover19
Two main mutational processes operate in the absence of DNA mismatch repair19
Chromosome breaks generated by low doses of ionizing radiation in G2-phase are processed exclusively by gene conversion19
GTPases, genome, actin: A hidden story in DNA damage response and repair mechanisms19
Understanding the sequence and structural context effects in oxidative DNA damage repair18
The dark side of homology-directed repair17
Increased DNA repair capacity augments resistance of glioblastoma cells to photodynamic therapy17
Mechanisms of direct replication restart at stressed replisomes17
Structure, function and evolution of the Helix-hairpin-Helix DNA glycosylase superfamily: Piecing together the evolutionary puzzle of DNA base damage repair mechanisms16
The role of telomeres and telomerase in the senescence of postmitotic cells16
Formation and repair of unavoidable, endogenous interstrand cross-links in cellular DNA16
Toxic R-loops: Cause or consequence of replication stress?16
Biochemical analysis of TOPBP1 oligomerization16
Function and evolution of the DNA-protein crosslink proteases Wss1 and SPRTN16
Molecular and structural characterization of disease-associated APE1 polymorphisms16
Untangling trapped topoisomerases with tyrosyl-DNA phosphodiesterases16
Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase 1 DNA-protein crosslinks and 3′-blocking lesions in the absence of tyrosyl-DNA phosphodiesterase 1 (TDP1)16
Large dataset of octocoral mitochondrial genomes provides new insights into mt-mutS evolution and function16
Significance and limitations of the use of next-generation sequencing technologies for detecting mutational signatures16
PARP1-mediated PARylation of TonEBP prevents R-loop–associated DNA damage16
Daughter-strand gaps in DNA replication – substrates of lesion processing and initiators of distress signalling15
CST in maintaining genome stability: Beyond telomeres15
Replication initiation: Implications in genome integrity15
Molecular basis for the MacroD1-mediated hydrolysis of ADP-ribosylation15
Pol β gap filling, DNA ligation and substrate-product channeling during base excision repair opposite oxidized 5-methylcytosine modifications15
C17orf53 is identified as a novel gene involved in inter-strand crosslink repair15
Cancer testis antigens and genomic instability: More than immunology14
The role of DNA damage response in chemo- and radio-resistance of cancer cells: Can DDR inhibitors sole the problem?14
Structural biology of DNA abasic site protection by SRAP proteins14
Helicobacter pylori severely reduces expression of DNA repair proteins PMS2 and ERCC1 in gastritis and gastric cancer14
Compromised repair of radiation-induced DNA double-strand breaks in Fanconi anemia fibroblasts in G213
Transcription-coupled repair and the transcriptional response to UV-Irradiation13
mTOR pathway and DNA damage response: A therapeutic strategy in cancer therapy13
The meiosis-specific MEIOB–SPATA22 complex cooperates with RPA to form a compacted mixed MEIOB/SPATA22/RPA/ssDNA complex13
Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes13
The role of histone H3K36me3 writers, readers and erasers in maintaining genome stability13
Understanding the DNA double-strand break repair and its therapeutic implications13
DNA damage response and breast cancer development: Possible therapeutic applications of ATR, ATM, PARP, BRCA1 inhibition13
The dual role of DNA repair protein MGMT in cancer prevention and treatment12
Regulation of UV damage repair in quiescent yeast cells12
Nucleophosmin interaction with APE1: Insights into DNA repair regulation12
Double strand break (DSB) repair in Cyanobacteria: Understanding the process in an ancient organism12
Role of histone acetyltransferases MOF and Tip60 in genome stability12
Non-canonical function of nuclear PTEN and its implication on tumorigenesis12
Transcription-coupled DNA double-strand break repair12
New twists to the ALTernative endings at telomeres12
HOTAIR beyond repression: In protein degradation, inflammation, DNA damage response, and cell signaling12
RNA helicase, DDX3X, is actively recruited to sites of DNA damage in live cells12
Olaparib enhances curcumin-mediated apoptosis in oral cancer cells by inducing PARP trapping through modulation of BER and chromatin assembly12
DNA polymerase β outperforms DNA polymerase γ in key mitochondrial base excision repair activities11
Non-canonical interaction of DNA repair proteins with intact and cleaved AP sites11
The cross-talk between signaling pathways, noncoding RNAs and DNA damage response: Emerging players in cancer progression11
MicroRNAs and the DNA damage response: How is cell fate determined?11
Transcriptional dysregulation of base excision repair proteins in breast cancer11
Perspectives on formaldehyde dysregulation: Mitochondrial DNA damage and repair in mammalian cells11
DNA damage response and PD-1/PD-L1 pathway in ovarian cancer11
Cyclin-dependent kinase inhibitors (CDKIs) and the DNA damage response: The link between signaling pathways and cancer11
Fine-tuning of DNA base excision/strand break repair via acetylation11
Double-strand breaks: When DNA repair events accidentally meet11
DNA repair pathways as guardians of the genome: Therapeutic potential and possible prognostic role in hematologic neoplasms11
Impacts of chromatin dynamics and compartmentalization on DNA repair11
Molecular analysis directs the prognosis, management and treatment of patients with xeroderma pigmentosum10
The “adductome”: A limited repertoire of adducted proteins in human cells10
DNA mismatch repair in the chromatin context: Mechanisms and therapeutic potential10
USP13 regulates the replication stress response by deubiquitinating TopBP110
Sp1-dependent recruitment of the histone acetylase p300 to DSBs facilitates chromatin remodeling and recruitment of the NHEJ repair factor Ku7010
Alteration of genetic recombination and double-strand break repair in human cells by progerin expression10
The multifaceted roles of DNA repair and replication proteins in aging and obesity10
miR-197-5p increases Doxorubicin-mediated anticancer cytotoxicity of HT1080 fibrosarcoma cells by decreasing drug efflux10
Proficiency in homologous recombination repair is prerequisite for activation of G2-checkpoint at low radiation doses10
Chaperoning histones at the DNA repair dance10
Requirements for PARP-1 covalent crosslinking to DNA (PARP-1 DPC)10
PCNA, a focus on replication stress and the alternative lengthening of telomeres pathway9
Telomere replication—When the going gets tough9
Size-dependent antirecombinogenic effect of short spacers on palindrome recombinogenicity9
Structural determinants of nucleobase modification recognition in the AlkB family of dioxygenases9
Hydroxychloroquine induces oxidative DNA damage and mutation in mammalian cells9
The DNA ligands Arg47 and Arg76 are crucial for catalysis by human PrimPol8
Sequence context effects of replication of Fapy•dG in three mutational hot spot sequences of the p53 gene in human cells8
Shining light on single-strand lesions caused by the chemotherapy drug bleomycin8
Analysis of mutational signatures in C. elegans: Implications for cancer genome analysis8
The RNF8 and RNF168 Ubiquitin Ligases Regulate Pro- and Anti-Resection Activities at Broken DNA Ends During Non-Homologous End Joining8
NELF complex fosters BRCA1 and RAD51 recruitment to DNA damage sites and modulates sensitivity to PARP inhibition8
New complexities of SOS-induced “untargeted” mutagenesis in Escherichia coli as revealed by mutation accumulation and whole-genome sequencing8
A DNA replication fork-centric view of the budding yeast DNA damage response8
Genome maintenance during embryogenesis8
Molecular dynamics simulations reveal how H3K56 acetylation impacts nucleosome structure to promote DNA exposure for lesion sensing8
Modulation of immune responses by DNA damage signaling8
Insights into the Direct Oxidative Repair of Etheno Lesions: MD and QM/MM Study on the Substrate Scope of ALKBH2 and AlkB8
Trinucleotide repeat instability via DNA base excision repair8
The fast-growing business of Serine ADP-ribosylation8
DNA double-strand break repair in male germ cells during spermatogenesis and its association with male infertility development8
Post-translational modification of factors involved in homologous recombination8
DNA damage-induced sumoylation of Sp1 induces its interaction with RNF4 and degradation in S phase to remove 53BP1 from DSBs and permit HR8
Multi-omic analysis of altered transcriptome and epigenetic signatures in the UV-induced DNA damage response8
Timely upstream events regulating nucleotide excision repair by ubiquitin-proteasome system: ubiquitin guides the way8
2-hexyl-4-pentynoic acid, a potential therapeutic for breast carcinoma by influencing RPA2 hyperphosphorylation-mediated DNA repair7
CometChip enables parallel analysis of multiple DNA repair activities7
The burden of overweight: Higher body mass index, but not vital exhaustion, is associated with higher DNA damage and lower DNA repair capacity7
Histone and Chromatin Dynamics Facilitating DNA repair7
The FAcilitates Chromatin Transcription (FACT) complex: Its roles in DNA repair and implications for cancer therapy7
Mysterious and fascinating: DNA polymerase ɩ remains enigmatic 20 years after its discovery7
Methylation of the central transcriptional regulator KLF4 by PRMT5 is required for DNA end resection and recombination7
The mRNA tether model for activation-induced deaminase and its relevance for Ig somatic hypermutation and class switch recombination7
Alternative complexes formed by the Escherichia coli clamp loader accessory protein HolC (x) with replication protein HolD (ψ) and repair protein YoaA7
Paradoxical role of the major DNA repair protein, OGG1, in action-at-a-distance mutation induction by 8-oxo-7,8-dihydroguanine7
Mechanisms of genome stability maintenance during cell division7
The interactions between DNA methylation machinery and long non-coding RNAs in tumor progression and drug resistance7
Histone variants H3.3 and H2A.Z/H3.3 facilitate excision of uracil from nucleosome core particles7
Variation in G-quadruplex sequence and topology differentially impacts human DNA polymerase fidelity7
Tissue-specific reduction in MLH1 expression induces microsatellite instability in intestine of Mlh1 mice7
Ubiquitylation in DNA double-strand break repair7
O-GlcNAc transferase is important for homology-directed repair7
An open-source platform to quantify subnuclear foci and protein colocalization in response to replication stress7
Impaired DNA repair in mouse monocytes compared to macrophages and precursors7
DNA polymerase β: Closing the gap between structure and function7
DNA-protein crosslinks are repaired via homologous recombination in mammalian mitochondria7
DNA damage and regulation of protein homeostasis7
G-quadruplex resolution: From molecular mechanisms to physiological relevance7
RNA in DNA repair7
Effects of radiotherapy and short-term starvation combination on metastatic and non-tumor cell lines6
Repair of DNA double-strand breaks in RNAPI- and RNAPII-transcribed loci6
How DNA damage and non-canonical nucleotides alter the telomerase catalytic cycle6
New insights into the DNA repair pathway choice with NuA4/TIP606
XRCC3 loss leads to midgestational embryonic lethality in mice6
The DNA damage induced immune response: Implications for cancer therapy6
Redirecting E2F1 to TA-p73 improves cancer therapy through apoptotic induction6
Three targets in one complex: A molecular perspective of TFIIH in cancer therapy6
Mechanism for R-loop formation remote from the transcription start site: Topological issues and possible facilitation by dissociation of RNA polymerase6
Cross-linking of the DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of cisplatin6
XPA deficiency affects the ubiquitin-proteasome system function6
To indel or not to indel: Factors influencing mutagenesis during chromosomal break end joining6
Histone lysine modifying enzymes and their critical roles in DNA double-strand break repair6
History of DNA polymerase β X-ray crystallography6
Biochemical characterization and mutational studies of a novel 3-methlyadenine DNA glycosylase II from the hyperthermophilic Thermococcus gammatolerans6
A novel DDB2 mutation causes defective recognition of UV-induced DNA damages and prevalent equine squamous cell carcinoma6
UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def16
Higher chromosome stability in embryonic neural stem and progenitor cells than in fibroblasts in response to acute or chronic genotoxic stress6
Kinetics model of DNA double-strand break repair in eukaryotes6
The Sm core components of small nuclear ribonucleoproteins promote homologous recombination repair5
Compartmentalization of the DNA damage response: Mechanisms and functions5
Structural insights into an MsmUdgX mutant capable of both crosslinking and uracil excision capability5
Histone variants: The unsung guardians of the genome5
Error-prone bypass patch by a low-fidelity variant of DNA polymerase zeta in human cells5
A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein5
Mechanisms of DNA repair in Trypanosoma cruzi: What do we know so far?5
Open gaps in the evolution of the eukaryotic nucleotide excision repair5
Fully automated counting of DNA damage foci in tumor cell culture: A matter of cell separation5
Low and high doses of ionizing radiation evoke discrete global (phospho)proteome responses5
Chromatin dynamics and DNA replication roadblocks5
Deciphering the role of distinct DNA-PK phosphorylations at collapsed replication forks5
Restoration of ligatable “clean” double-strand break ends is the rate-limiting step in the rejoining of ionizing-radiation-induced DNA breakage5
The N-terminal domain of uracil-DNA glycosylase: Roles for disordered regions5
Cockayne syndrome group B protein uses its DNA translocase activity to promote mitotic DNA synthesis5
Modifications and interactions at the R-loop5
hMTH1 and GPX1 expression in human thyroid tissue is interrelated to prevent oxidative DNA damage5
Structure and mechanism in non-homologous end joining5
Obstacles and opportunities for base excision repair in chromatin5
Set1-dependent H3K4 methylation becomes critical for limiting DNA damage in response to changes in S-phase dynamics in Saccharomyces cerevisiae5
Mutational analysis of Thermococcus kodakarensis Endonuclease III reveals the roles of evolutionarily conserved residues5
DNA glycosylases for 8-oxoguanine repair in Staphylococcus aureus5
Hydrogen peroxide and Helicobacter pylori extract treatment combined with APE1 knockdown induce DNA damage, G2/M arrest and cell death in gastric cancer cell line5
Impact of DNA sequences on DNA ‘opening’ by the Rad4/XPC nucleotide excision repair complex5
The DNA damage-sensing NER repair factor XPC-RAD23B does not recognize bulky DNA lesions with a missing nucleotide opposite the lesion5
Real-time investigation of the roles of ATP hydrolysis by UvrA and UvrB during DNA damage recognition in nucleotide excision repair5
TOPBP1 regulates resistance of gastric cancer to oxaliplatin by promoting transcription of PARP15
dCas9 binding inhibits the initiation of base excision repair in vitro5
Single-molecule studies of helicases and translocases in prokaryotic genome-maintenance pathways4
Role of the multifunctional transcription factor TFII-I in DNA damage repair4
Chk1 inhibition induces a DNA damage bystander effect in cocultured tumour cells4
Interaction of Wwox with Brca1 and associated complex proteins prevents premature resection at double-strand breaks and aberrant homologous recombination4
Chromosomal aberration dynamics through the cell cycle4
Plasmodium Ape1 is a multifunctional enzyme in mitochondrial base excision repair and is required for efficient transition from liver to blood stage infection4
DNA repair gene polymorphisms and chromosomal aberrations in healthy, nonsmoking population4
Mitochondrial apurinic/apyrimidinic endonuclease Apn1 is not critical for the completion of the Plasmodium berghei life cycle4
Pan-cancer antagonistic inhibition pattern of ATM-driven G2/M checkpoint pathway vs other DNA repair pathways4
DNA damage response and repair in pancreatic cancer development and therapy4
Reported DNA repair protein CECR2, which is associated with neural tube defects in mice, is not required for double-strand break repair in primary neurospheres4
The multifaceted functions of homologous recombination in dealing with replication-associated DNA damages4
The C-terminal domain of Arabidopsis ROS1 DNA demethylase interacts with histone H3 and is required for DNA binding and catalytic activity4
Fluorescently labeled human apurinic/apyrimidinic endonuclease APE1 reveals effects of DNA polymerase β on the APE1–DNA interaction4
Multifunctional properties of Nej1XLF C-terminus promote end-joining and impact DNA double-strand break repair pathway choice4
DEF1: Much more than an RNA polymerase degradation factor4
Heterogeneity of DNA damage incidence and repair in different chromatin contexts4
Post-translational regulation of Tyrosyl-DNA phosphodiesterase (TDP1 and TDP2) for the repair of the trapped topoisomerase-DNA covalent complex4
Centromere: A Trojan horse for genome stability4
Measurement of uracil-DNA glycosylase activity by matrix assisted laser desorption/ionization time-of-flight mass spectrometry technique4
Genome integrity and inflammation in the nervous system4
RETRACTED: Thymoquinone sensitizes human hepatocarcinoma cells to TRAIL-induced apoptosis via oxidative DNA damage4
Mechanisms of SSBP1 variants in mitochondrial disease: Molecular dynamics simulations reveal stable tetramers with altered DNA binding surfaces4
The rate of formation and stability of abasic site interstrand crosslinks in the DNA duplex4
Collaborations between chromatin and nuclear architecture to optimize DNA repair fidelity4
Replication dependent and independent mechanisms of GAA repeat instability4
Treatment of human cells with 5-aza-dC induces formation of PARP1-DNA covalent adducts at genomic regions targeted by DNMT14
Tyrosyl-DNA phosphodiesterase 1 excises the 3′-DNA-ALKBH1 cross-link and its application for 3′-DNA-ALKBH1 cross-link characterization by LC-MS/MS4
Nanoscale insight into chromatin remodeling and DNA repair complex in HeLa cells after ionizing radiation4
The ataxia-telangiectasia mutated gene product regulates the cellular acid-labile sulfide fraction3
Yeast DNA polymerase η possesses two PIP-like motifs that bind PCNA and Rad6-Rad18 with different specificities3