Ageing Research Reviews

Article	Citations
Start the engine of neuroregeneration: A mechanistic and strategic overview of direct astrocyte-to-neuron reprogramming	572
DNA methylation in genes associated with the evolution of ageing and disease: A critical review	282
Editorial Board	282
The unique neuropathological vulnerability of the human brain to aging	269
The functions of IRE1α in neurodegenerative diseases: Beyond ER stress	245
Adenosine metabolism and receptors in aging of the skin, musculoskeletal, immune and cardiovascular systems	239
Roles of hypoxia-inducible factor-prolyl hydroxylases in aging and disease	235
Effectiveness of virtual reality interventions on quality of life, cognitive function and physical function in older people with Alzheimer's disease: A systematic review	232
Dysfunction of norepinephrine and its metabolites in Alzheimer's dementia – A review with meta-analysis	228
Editorial Board	226
Discovery of a new hereditary RECQ helicase disorder RECON syndrome positions the replication stress response and genome homeostasis as centrally important processes in aging and age-related disease	206
CC chemokines family in fibrosis and aging: From mechanisms to therapy	185
Medication reviews in hospitalised patients for reduced hospital readmission and mortality. Systematic review, meta-analysis and meta-regression of RCTs	181
Can dementia risk be reduced by following the American Heart Association's Life's Simple 7? A systematic review and dose-response meta-analysis	180
Advances in clinical application of lipidomics in healthy ageing and healthy longevity medicine	179
Editor’s Note to “Biological constraint, evolutionary spandrels and antagonistic pleiotropy”	177
HIV infection is associated with accelerated epigenetic ageing: A systematic review	159
Does drug repurposing bridge the gaps in management of Parkinson’s disease? Unravelling the facts and fallacies	151
Type 2 diabetes mellitus augments Parkinson’s disease risk or the other way around: Facts, challenges and future possibilities	149
Histopathological and ultrastructural changes in different cell types during ischemic and hemorrhagic stroke	146
Rethinking IRPs/IRE system in neurodegenerative disorders: Looking beyond iron metabolism	146
Sarcobesity: New paradigms for healthy aging related to taurine supplementation, gut microbiota and exercise	139
Thioredoxin-1 inhibits the activation of IRE1 by targeting Hsp90/p-Cdc37 chaperone complex in Parkinson disease	136
Unravelling the brain resilience following stroke: From injury to rewiring of the brain through pathway activation, drug targets, and therapeutic interventions	131
Repetitive transcranial magnetic stimulation combined with cognitive training for cognitive function and activities of daily living in patients with post-stroke cognitive impairment: A systematic revi	125

Advances in Alzheimer's therapy: Exploring neuropathological mechanisms to revolutionize the future therapeutic landscape	124
Vascular cognitive impairment – Past, present, and future challenges	123
Prevalence and health outcomes of polypharmacy and hyperpolypharmacy in older adults with frailty: A systematic review and meta-analysis	123
Efficacy of technology-based cognitive and exercise interventions for mild cognitive impairment: A systematic review, network meta-analysis, and meta-regression of randomized controlled trials	122
Artificial intelligence in brain MRI analysis of Alzheimer’s disease over the past 12 years: A systematic review	122
Global, regional, and national burden of spinal cord injury from 1990 to 2021 and projections for 2050: A systematic analysis for the Global Burden of Disease 2021 study	120
Optimal dose and type of exercise to improve cognitive function in older adults: A systematic review and bayesian model-based network meta-analysis of RCTs	120
Unraveling the protein post-translational modification landscape: Neuroinflammation and neuronal death after stroke	117
Biomarkers associated with cognitive impairment in post-traumatic stress disorder: A systematic review of current evidence	115
Transcranial direct current stimulation combined with motor training for motor symptoms in Parkinson's disease: A systematic review and meta-analysis	115
Advances of artificial intelligence in predicting frailty using real-world data: A scoping review	115
Microglia and gut microbiota: A double-edged sword in Alzheimer's disease	115
Adherence to the Mediterranean diet and risk of frailty and pre-frailty in elderly adults: A systematic review and dose-response meta-analysis with GRADE assessment	113
Betaine and aging: A narrative review of findings, possible mechanisms, research perspectives, and practical recommendations	111
Cytosolic DNA sensor IFI16 proteins: Potential molecular integrators of interactions among the aging hallmarks	108
Unravelling the miscellaneous effects of exercise interventions on activities of daily living in frail older adults: A systematic review and meta-analysis	107
The role of the gut microbiota in neuropsychiatric disorders and therapy	106
Involvement of regulated cell deaths in aging and age-related pathologies	104
Triaging between post-translational modification of cell cycle regulators and their therapeutics in neurodegenerative diseases	103
Targeting aging with urolithin A in humans: A systematic review	102
The role of the PLA2G6 gene in neurodegenerative diseases	102
Cognitive resilience in Alzheimer’s disease: Mechanism and potential clinical intervention	100
The mitochondrial integrated stress response: A novel approach to anti-aging and pro-longevity	99
Interventions to prevent and treat delirium: An umbrella review of randomized controlled trials	98
Searching for the link between inflammaging and sarcopenia	98
Potential convergence of olfactory dysfunction in Parkinson’s disease and COVID-19: The role of neuroinflammation	96
Overview of pro-inflammatory and pro-survival components in neuroinflammatory signalling and neurodegeneration	96
The link between metabolic syndrome and Alzheimer disease: A mutual relationship and long rigorous investigation	95
Melatonin: Potential avenue for treating iron overload disorders	92
Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseases	92
On the wake of metformin: Do anti-diabetic SGLT2 inhibitors exert anti-aging effects?	89
The effectiveness of dance movement interventions for older adults with mild cognitive impairment, Alzheimer’s disease, and dementia: A systematic scoping review and meta-analysis	89
Identification of exosomal biomarkers and its optimal isolation and detection method for the diagnosis of Parkinson's disease: A systematic review and meta-analysis	88
Associations of olfactory function with brain structural and functional outcomes. A systematic review	87
New era of artificial intelligence and machine learning-based detection, diagnosis, and therapeutics in Parkinson’s disease	86
Bridging neurotrophic factors and bioactive peptides to Alzheimer's disease	85
Neuroprotection by agmatine: Possible involvement of the gut microbiome?	85
HMGB1, an evolving pleiotropic protein critical for cellular and tissue homeostasis: Role in aging and age-related diseases	83
Hallmarks of aging: A user’s guide for comparative biologists	83
Role of diet and exercise in aging, Alzheimer’s disease, and other chronic diseases	83
The several ways to authentically cure Alzheimer’s dementia	82
Sensory nerve regulation of bone homeostasis: Emerging therapeutic opportunities for bone-related diseases	82
Research progress in Alzheimer's disease and bone-brain axis	81
A Multimodal Meta-Analytical Evidence of Functional and Structural Brain Abnormalities Across Alzheimer's Disease Spectrum	81
Modifiable lifestyle factors and cognitive reserve: A systematic review of current evidence	81
Characterization of the logopenic variant of Primary Progressive Aphasia: A systematic review and meta-analysis	80
Beyond the Hayflick limit: How microbes influence cellular aging	80
Latest developments of microphysiological systems (MPS) in aging-related and geriatric diseases research: A review	80
Turquoise killifish: A natural model of age-dependent brain degeneration	79
Healthy brain aging and delayed dementia in Texas rural elderly	78

Current research status of blood biomarkers in Alzheimer’s disease: Diagnosis and prognosis	77
Modifiable risk factors for mild cognitive impairment among cognitively normal community-dwelling older adults: A systematic review and meta-analysis	77
Modulators of ASIC1a and its potential as a therapeutic target for age-related diseases	76
ADP-ribosylation, a multifaceted modification: Functions and mechanisms in aging and aging-related diseases	76
A novel regulator in Alzheimer's disease progression: The astrocyte-derived extracellular vesicles	76
Genetic mechanisms of aging in plants: What can we learn from them?	75
Intracellular effects of lithium in aging neurons	75
The role of exercise in the prevention and treatment of Alzheimer’s disease and mild cognitive impairments	75
A critical appraisal of blood-based biomarkers for Alzheimer’s disease	75
Biological constraint, evolutionary spandrels and antagonistic pleiotropy	75
Interactions between glial cells and the blood-brain barrier and their role in Alzheimer's disease	74
Association between pulse wave velocity and white matter hyperintensities among older adults: A meta-analysis of cross-sectional and longitudinal studies	74
Unravelling of molecular biomarkers in synaptic plasticity of Alzheimer’s disease: Critical role of the restoration of neuronal circuits	73
The cross-talk between the cGAS-STING signaling pathway and chronic inflammation in the development of musculoskeletal disorders	72
Expanding evolutionary theories of ageing to better account for symbioses and interactions throughout the Web of Life	72
Under the umbrella of depression and Alzheimer’s disease physiopathology: Can cannabinoids be a dual-pleiotropic therapy?	72
The plasticity of fibroblasts: A forgotten player in the aging process	71
Long-term human spaceflight and inflammaging: Does it promote aging?	71
Regulated cell death in acute myocardial infarction: Molecular mechanisms and therapeutic implications	71
The future of stem cell therapies of Alzheimer’s disease	71
Suicide and dementia: A systematic review and meta-analysis of prevalence and risk factors	68
Association of frailty and pre-frailty with all-cause and cardiovascular mortality in diabetes: Three prospective cohorts and a meta-analysis	68
Drug repositioning for Parkinson’s disease: An emphasis on artificial intelligence approaches	68
Aryl hydrocarbon receptor: From pathogenesis to therapeutic targets in aging-related tissue fibrosis	68
Molecular hydrogen therapy: A “democratic” emerging strategy against aging and age-related diseases	67
Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer’s disease: Past, present and future	67
Oral health indicators and bone mineral density disorders in older age: A systematic review	67
Computerized cognitive training in Parkinson’s disease: A systematic review and meta-analysis	67
Exercise interventions in Alzheimer’s disease: A systematic review and meta-analysis of randomized controlled trials	66
cGAS-STING targeting offers novel therapeutic opportunities in neurological diseases	66
Global burden, risk factors, and projections of early-onset dementia: Insights from the Global Burden of Disease Study 2021	66
Targeting the gut microbiota-related metabolites for osteoporosis: The inextricable connection of gut-bone axis	66
The effect of ferroptosis-related mitochondrial dysfunction in the development of temporal lobe epilepsy	66
Role of Nrf2 in aging, Alzheimer’s and other neurodegenerative diseases	66
Antioxidants in anti‐Alzheimer's disease drug discovery	65
Mortality prediction models for community-dwelling older adults: A systematic review	65
Brain drug delivery and neurodegenerative diseases: Polymeric PLGA-based nanoparticles as a forefront platform	65
Restoration of epigenetic impairment in the skeletal muscle and chronic inflammation resolution as a therapeutic approach in sarcopenia	64
The mechanisms of mitochondrial abnormalities that contribute to sleep disorders and related neurodegenerative diseases	64
Biomarkers of female reproductive aging in gerotherapeutic clinical trials	63
Transposable elements and their role in aging	62
Association between lipocalin-2 and mild cognitive impairment or dementia: A systematic review and meta-analysis of population-based evidence	61
Editorial Board	61
A review on neurodegeneration in the fast-ageing killifish, the first animal model to study the natural occurrence of neuronal cell loss	61
Aryl hydrocarbon receptor (AhR) impairs circadian regulation: Impact on the aging process	61
The memory- and cognition-facilitating effects of spermidine in aging and aging-related disorders	60
Is COVID-19 really a geriatric syndrome?	60
Underserved groups in dysphagia intervention trials in Parkinson’s disease: A scoping review	60
Consolidating multiple evolutionary theories of ageing suggests a need for new approaches to study genetic contributions to ageing decline	60
From onset to advancement: the temporal spectrum of α-synuclein in synucleinopathies	59
BACE1-dependent metabolism of neuregulin 1: Bridging the gap in explaining the occurrence of schizophrenia-like symptoms in Alzheimer's disease with psychosis?	59
Telomere length and brain aging: A systematic review and meta-analysis	58
Recent advancement in understanding of Alzheimer's disease: Risk factors, subtypes, and drug targets and potential therapeutics	58
The metabolic and endocrine impact of diet-derived gut microbiota metabolites on ageing and longevity	58
A tale of two systems: Lessons learned from female mid-life aging with implications for Alzheimer’s prevention & treatment	58
Hormesis defines the limits of lifespan	58
Resolution of inflammation, an active process to restore the immune microenvironment balance: A novel drug target for treating arterial hypertension	58
From corpora amylacea to wasteosomes: History and perspectives	58
Unlocking the potential of histone deacetylase inhibitors in combatting age-related retinal degenerative diseases	57
Small molecule modulators of alpha-synuclein aggregation and toxicity: Pioneering an emerging arsenal against Parkinson’s disease	57
Alzheimer's disease and Alzheimer’s disease-related dementias in Hispanics: Identifying influential factors and supporting caregivers	57
Editorial Board	56
The mechanism of cuproptosis in Parkinson’s disease	56
Neurobiology of depression in Parkinson’s disease: Insights into epidemiology, molecular mechanisms and treatment strategies	56
Sirtuins in Parkinson's disease: Molecular mechanisms and pathophysiological roles	55
Cerebellar pathology in forensic and clinical neuroscience	54
RNA binding proteins in senescence: A potential common linker for age-related diseases?	54
FAM19A5 in vascular aging and osteoporosis: Mechanisms and the “calcification paradox”	54
Long-term fasting and its influence on inflammatory biomarkers: A comprehensive scoping review	54
Effect of ketogenic diets on insulin-like growth factor (IGF)-1 in humans: A systematic review and meta-analysis	54
Prevalence of psychotic symptoms in mild cognitive impairment: A systematic review and meta-analysis	54
Cerebral small vessel disease pathology in COVID-19 patients: A systematic review	53
Fractal dimension of the brain in neurodegenerative disease and dementia: A systematic review	53
Impact of exercise intervention-based changes on physical function biomarkers in older adults after hospital discharge: A systematic review with meta-analysis of randomized clinical trials	53
Single-cell sequencing insights into the transcriptional landscape of Parkinson's disease	53
The senotherapeutic potential of phytochemicals for age-related intestinal disease	53
Blood pressure variability: A potential marker of aging	53
Understanding age-related pathologic changes in TDP-43 functions and the consequence on RNA splicing and signalling in health and disease	53
Epigenetic biomarkers in Alzheimer's disease: Diagnostic and prognostic relevance	53
Impact of frailty on all-cause mortality or major amputation in patients with lower extremity peripheral artery disease: A meta-analysis	52

Heat stroke: Pathogenesis, diagnosis, and current treatment	52
Associations between vision impairment and eye diseases with dementia, dementia subtypes and cognitive impairment: An umbrella review	52
Modulating α-synuclein propagation and decomposition: Implications in Parkinson's disease therapy	52
Efficacy of rehabilitation robot-assisted gait training on lower extremity dyskinesia in patients with Parkinson's disease: A systematic review and meta-analysis	52
Biological resilience and aging: Activation of stress response pathways contributes to lifespan extension	52
Multi-omics strategies to decode the molecular landscape of cellular senescence	52
Glial cells in Alzheimer’s disease: From neuropathological changes to therapeutic implications	51
The role of nutrition in inflammaging	51
Exploring Parkinson-associated kinases for CRISPR/Cas9-based gene editing: beyond alpha-synuclein	51
Oxidative stress: The core pathogenesis and mechanism of Alzheimer’s disease	51
Mitochondrial transfer between cell crosstalk – An emerging role in mitochondrial quality control	51
The interplay of NAD and hypoxic stress and its relevance for ageing	50
Prevalence of alcohol use among U.S. older adults with pain: A scoping review	50
Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central nervous system	50
Breakdown of specific functional brain networks in clinical variants of Alzheimer’s disease	50
The prognostic impacts of frailty on clinical and patient-reported outcomes in patients undergoing coronary artery or valvular surgeries/procedures: A systematic review and meta-analysis	50
Is cognitive reserve associated with the prevention of cognitive decline after stroke? A Systematic review and meta-analysis	49
Pregnancy, preeclampsia and maternal aging: From epidemiology to functional genomics	49
Updates on brain regions and neuronal circuits of movement disorders in Parkinson’s disease	49
Dementia, osteoporosis and fragility fractures: Intricate epidemiological relationships, plausible biological connections, and twisted clinical practices	49
A cross-talk between sestrins, chronic inflammation and cellular senescence governs the development of age-associated sarcopenia and obesity	49
Adipose tissue and ovarian aging: Potential mechanism and protective strategies	48
Editorial Board	48
Towards a comprehensive framework for complex walking tasks: Characterization, behavioral adaptations, and clinical implications in ageing and neurological populations	48
Targeting impaired nutrient sensing via the sirtuin pathway with novel compounds to prevent or treat dementia: A systematic review	48
Editorial Board	48
Markers of biological age in dogs	48
Editorial Board	48
Osteosarcopenic adiposity (OSA) phenotype and its connection with cardiometabolic disorders: Is there a cause-and-effect?	47
The conceivable role of prolactin hormone in Parkinson disease: The same goal but with different ways	47
Deciphering the mechanistic impact of acupuncture on the neurovascular unit in acute ischemic stroke: Insights from basic research in a narrative review	47
Effects of exercise interventions on cognitive functions in healthy populations: A systematic review and meta-analysis	47
Resolving the current controversy of use and reuse of housekeeping proteins in ageing research: Focus on saving people’s tax dollars	47
Osteoporosis and Alzheimer´s disease (or Alzheimer´s disease and Osteoporosis)	46
The role of serotonin within the microbiota-gut-brain axis in the development of Alzheimer’s disease: A narrative review	46
The role of oxidative stress in intervertebral disc degeneration: Mechanisms and therapeutic implications	46
Cannabidiol and neurodegeneration: From molecular mechanisms to clinical benefits	46
MSC-EVs alleviate osteoarthritis by regulating microenvironmental cells in the articular cavity and maintaining cartilage matrix homeostasis	45
Neurobiological role and therapeutic potential of exercise-induced irisin in Alzheimer's disease management	45
Multi-omics research strategies in ischemic stroke: A multidimensional perspective	45
Unknown roles of tau pathology in neurological disorders. Challenges and new perspectives	44
Exerkines: Potential regulators of diabetic cardiomyopathy	44
Editorial Board	44
Interlinked role of ASN, TDP-43 and Miro1 with parkinopathy: Focus on targeted approach against neuropathy in parkinsonism	44
Therapeutic potential of lipid nanosystems for the treatment of Parkinson’s disease	44
Epigenetic clock: A promising biomarker and practical tool in aging	44
The association of living alone and social isolation with sarcopenia: A systematic review and meta-analysis	43
Risk factors for multimorbidity in adulthood: A systematic review	43
Editorial Board	43
Poly (ADP-ribose) polymerase 1 and neurodegenerative diseases: Past, present, and future	43
Semaglutide as a possible therapy for healthy aging: Targeting the hallmarks of aging	43
Is it time to revise the fighting strategy toward type 2 diabetes? Sex and pollution as new risk factors	43
Immunometabolism and immune response regulate macrophage function in atherosclerosis	42
Developing transcriptomic signatures as a biomarker of cellular senescence	42
Reducing Alzheimer’s disease risk with SGLT2 inhibitors: From glycemic control to neuroprotection	42
Advancements in computer-assisted diagnosis of Alzheimer's disease: A comprehensive survey of neuroimaging methods and AI techniques for early detection	42
Gut microbiome and Alzheimer’s disease: What we know and what remains to be explored	42
The impact of aging on HIV-1-related neurocognitive impairment	41
Emerging therapeutics agents and recent advances in drug repurposing for Alzheimer’s disease	41
Prevention of cardiovascular disease for healthy aging and longevity: A new scoring system and related “mechanisms-hallmarks-biomarkers”	41
Advances in human cellular mechanistic understanding and drug discovery of brain organoids for neurodegenerative diseases	41
Reply to “Caution in underrepresentation of older adults in clinical trials on COVID-19 vaccines”	41
Priorities in tackling noncommunicable diseases among the population aged 60 years and older in China, 1990–2021: A population-based study	40
Immersive virtual reality for older adults: Challenges and solutions in basic research and clinical applications	40
Mapping the immune-genetic architecture of aging: A single-cell causal framework for biomarker discovery and therapeutic targeting	39
Rebalancing the unbalanced aged immune system – A special focus on zinc	39
Platelets: A new therapeutic target for neurological diseases	39
The hallmarks of aging in Ataxia-Telangiectasia	38
Exploring cytokines dynamics: Uncovering therapeutic concepts for metabolic disorders in postmenopausal women- diabetes, metabolic bone diseases, and non-alcohol fatty liver disease	38
Macrophage membrane-camouflaged biomimetic nanovesicles for targeted treatment of arthritis	38
Motoric cognitive risk syndrome as a predictive factor of cognitive impairment and dementia – A systematic review and meta-analysis	37
Target modulation of glycolytic pathways as a new strategy for the treatment of neuroinflammatory diseases	37
Pyroptosis: Mechanisms and links with diabetic cardiomyopathy	37
The oral organ: A new vision of the mouth as a whole for a gerophysiological approach to healthy aging	37
Role of UCHL1 in the pathogenesis of neurodegenerative diseases and brain injury	37
Precision neurology	37
Reelin links Apolipoprotein E4, Tau, and Amyloid‐β in Alzheimer’s disease	36
Progress in the mechanisms of pain associated with neurodegenerative diseases	36
Curcumin-loaded polymeric nanomaterials as a novel therapeutic strategy for Alzheimer's disease: A comprehensive review	36
Definitions of healthspan: A systematic review	36
Evolving landscape of colorectal cancer: Global and regional burden, risk factor dynamics, and future scenarios (the Global Burden of Disease 1990–2050)	36
Modulating the polarization phenotype of microglia – A valuable strategy for central nervous system diseases	36
Harnessing two-dimensional nanomaterials for diagnosis and therapy in neurodegenerative diseases: Advances, challenges and prospects	36
Sarcopenia defined by the psoas muscle mass or quality is associated with poor survival in patients with aortic aneurysm undergoing surgery: A meta-analysis	36
Pancreatic β-cell remodeling in health and aging: Lessons from rodents and humans	35
Is the renin-angiotensin system a friend or foe in neurological diseases? Unveiling its role and therapeutic potential	35
A systematic review of one-legged balance performance and falls risk in community-dwelling adults	35
Informal caregivers’ attitudes towards care robots: A mixed methods systematic review	35
A systematic review of the effect and mechanism of Daoyin therapy on improving mild cognitive impairment in older adults	35
Cognition on the move: Examining the role of physical exercise and neurogenesis in counteracting cognitive aging	35
Past, present, and future of serotonin-targeting therapeutics for Alzheimer’s disease: Perspectives from DNA methylation	35
The prognostic utility of CSF neurogranin in predicting future cognitive decline in the Alzheimer’s disease continuum: A systematic review and meta-analysis with narrative synthesis	34
Unraveling the mystery of citrate transporters in Alzheimer’s disease: An updated review	34
Physical activity and neurotrophic factors as potential drivers of neuroplasticity in Parkinson’s Disease: A systematic review and meta-analysis	34
Nanomedical approaches in the realm of rheumatoid arthritis	34