Ageing Research Reviews

Article	Citations
Thioredoxin-1 inhibits the activation of IRE1 by targeting Hsp90/p-Cdc37 chaperone complex in Parkinson disease	404
Editorial Board	378
Roles of hypoxia-inducible factor-prolyl hydroxylases in aging and disease	333
Medication reviews in hospitalised patients for reduced hospital readmission and mortality. Systematic review, meta-analysis and meta-regression of RCTs	280
Does drug repurposing bridge the gaps in management of Parkinson’s disease? Unravelling the facts and fallacies	225
Adenosine metabolism and receptors in aging of the skin, musculoskeletal, immune and cardiovascular systems	218
Editorial Board	214
Sarcobesity: New paradigms for healthy aging related to taurine supplementation, gut microbiota and exercise	212
Discovery of a new hereditary RECQ helicase disorder RECON syndrome positions the replication stress response and genome homeostasis as centrally important processes in aging and age-related disease	209
The unique neuropathological vulnerability of the human brain to aging	194
Type 2 diabetes mellitus augments Parkinson’s disease risk or the other way around: Facts, challenges and future possibilities	193
Redox imbalance in age-related ovarian dysfunction and perspectives for its prevention	192
The protein inputs of an ultra-predictive aging clock represent viable anti-aging drug targets	170
Editorial Board	168
Advances in clinical application of lipidomics in healthy ageing and healthy longevity medicine	165
Microglia and gut microbiota: A double-edged sword in Alzheimer's disease	147
The functions of IRE1α in neurodegenerative diseases: Beyond ER stress	145
DNA methylation in genes associated with the evolution of ageing and disease: A critical review	145
Dysfunction of norepinephrine and its metabolites in Alzheimer's dementia – A review with meta-analysis	142
How good is the evidence that cellular senescence causes skin ageing?	138
Vascular cognitive impairment – Past, present, and future challenges	138
Efficacy of technology-based cognitive and exercise interventions for mild cognitive impairment: A systematic review, network meta-analysis, and meta-regression of randomized controlled trials	137
Repetitive transcranial magnetic stimulation combined with cognitive training for cognitive function and activities of daily living in patients with post-stroke cognitive impairment: A systematic revi	136
Prevalence and health outcomes of polypharmacy and hyperpolypharmacy in older adults with frailty: A systematic review and meta-analysis	136
Can dementia risk be reduced by following the American Heart Association's Life's Simple 7? A systematic review and dose-response meta-analysis	133

Rethinking IRPs/IRE system in neurodegenerative disorders: Looking beyond iron metabolism	133
Unraveling the protein post-translational modification landscape: Neuroinflammation and neuronal death after stroke	129
Global, regional, and national burden of spinal cord injury from 1990 to 2021 and projections for 2050: A systematic analysis for the Global Burden of Disease 2021 study	125
Artificial intelligence in brain MRI analysis of Alzheimer’s disease over the past 12 years: A systematic review	124
miR-21 and miR-146a: The microRNAs of inflammaging and age-related diseases	123
Optimal dose and type of exercise to improve cognitive function in older adults: A systematic review and bayesian model-based network meta-analysis of RCTs	122
CC chemokines family in fibrosis and aging: From mechanisms to therapy	121
Updated systematic review and meta-analysis on diagnostic issues and the prognostic impact of myosteatosis: A new paradigm beyond sarcopenia	115
Adherence to the Mediterranean diet and risk of frailty and pre-frailty in elderly adults: A systematic review and dose-response meta-analysis with GRADE assessment	113
Interventions to prevent and treat delirium: An umbrella review of randomized controlled trials	112
Hallmarks of aging: A user’s guide for comparative biologists	107
HMGB1, an evolving pleiotropic protein critical for cellular and tissue homeostasis: Role in aging and age-related diseases	107
Triaging between post-translational modification of cell cycle regulators and their therapeutics in neurodegenerative diseases	106
Biomarkers associated with cognitive impairment in post-traumatic stress disorder: A systematic review of current evidence	104
Research progress in Alzheimer's disease and bone-brain axis	104
Involvement of regulated cell deaths in aging and age-related pathologies	102
Advances of artificial intelligence in predicting frailty using real-world data: A scoping review	99
Neuroprotection by agmatine: Possible involvement of the gut microbiome?	98
Searching for the link between inflammaging and sarcopenia	98
Bridging neurotrophic factors and bioactive peptides to Alzheimer's disease	97
Targeting aging with urolithin A in humans: A systematic review	97
The mitochondrial integrated stress response: A novel approach to anti-aging and pro-longevity	96
Targeting immune dysfunction in aging	96
Associations of olfactory function with brain structural and functional outcomes. A systematic review	95
Cytosolic DNA sensor IFI16 proteins: Potential molecular integrators of interactions among the aging hallmarks	94
The several ways to authentically cure Alzheimer’s dementia	93
Betaine and aging: A narrative review of findings, possible mechanisms, research perspectives, and practical recommendations	92
Cognitive resilience in Alzheimer’s disease: Mechanism and potential clinical intervention	91
Targeting impaired nutrient sensing with repurposed therapeutics to prevent or treat age-related cognitive decline and dementia: A systematic review	91
Quantifying physical activity in aged residential care facilities: A structured review	89
Sensory nerve regulation of bone homeostasis: Emerging therapeutic opportunities for bone-related diseases	88
On the wake of metformin: Do anti-diabetic SGLT2 inhibitors exert anti-aging effects?	87
Identification of exosomal biomarkers and its optimal isolation and detection method for the diagnosis of Parkinson's disease: A systematic review and meta-analysis	85
Potential convergence of olfactory dysfunction in Parkinson’s disease and COVID-19: The role of neuroinflammation	85
Overview of pro-inflammatory and pro-survival components in neuroinflammatory signalling and neurodegeneration	85
Melatonin: Potential avenue for treating iron overload disorders	84
The link between metabolic syndrome and Alzheimer disease: A mutual relationship and long rigorous investigation	83
Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseases	83
Omics sciences for systems biology in Alzheimer’s disease: State-of-the-art of the evidence	82
Modifiable lifestyle factors and cognitive reserve: A systematic review of current evidence	81
The role of the PLA2G6 gene in neurodegenerative diseases	81
Role of diet and exercise in aging, Alzheimer’s disease, and other chronic diseases	80
Cross-sectional and longitudinal associations between adherence to Mediterranean diet with physical performance and cognitive function in older adults: A systematic review and meta-analysis	80
Exercise training increases telomerase reverse transcriptase gene expression and telomerase activity: A systematic review and meta-analysis	77
New era of artificial intelligence and machine learning-based detection, diagnosis, and therapeutics in Parkinson’s disease	77
The effectiveness of dance movement interventions for older adults with mild cognitive impairment, Alzheimer’s disease, and dementia: A systematic scoping review and meta-analysis	76
A Multimodal Meta-Analytical Evidence of Functional and Structural Brain Abnormalities Across Alzheimer's Disease Spectrum	74
Genetic mechanisms of aging in plants: What can we learn from them?	72
Characterization of the logopenic variant of Primary Progressive Aphasia: A systematic review and meta-analysis	72
cGAS-STING targeting offers novel therapeutic opportunities in neurological diseases	72

Intracellular effects of lithium in aging neurons	72
Unravelling of molecular biomarkers in synaptic plasticity of Alzheimer’s disease: Critical role of the restoration of neuronal circuits	71
A critical appraisal of blood-based biomarkers for Alzheimer’s disease	71
Drug repositioning for Parkinson’s disease: An emphasis on artificial intelligence approaches	71
Suicide and dementia: A systematic review and meta-analysis of prevalence and risk factors	71
Latest developments of microphysiological systems (MPS) in aging-related and geriatric diseases research: A review	70
The cross-talk between the cGAS-STING signaling pathway and chronic inflammation in the development of musculoskeletal disorders	70
Aryl hydrocarbon receptor: From pathogenesis to therapeutic targets in aging-related tissue fibrosis	70
A novel regulator in Alzheimer's disease progression: The astrocyte-derived extracellular vesicles	69
Dissecting primary and secondary senescence to enable new senotherapeutic strategies	69
The future of stem cell therapies of Alzheimer’s disease	69
Exercise interventions in Alzheimer’s disease: A systematic review and meta-analysis of randomized controlled trials	69
Biological constraint, evolutionary spandrels and antagonistic pleiotropy	68
Turquoise killifish: A natural model of age-dependent brain degeneration	67
The emerging role of the sympathetic nervous system in skeletal muscle motor innervation and sarcopenia	67
Regulated cell death in acute myocardial infarction: Molecular mechanisms and therapeutic implications	66
Current research status of blood biomarkers in Alzheimer’s disease: Diagnosis and prognosis	66
Long-term human spaceflight and inflammaging: Does it promote aging?	66
Oral health indicators and bone mineral density disorders in older age: A systematic review	65
Unsupervised home-based resistance training for community-dwelling older adults: A systematic review and meta-analysis of randomized controlled trials	65
Modifiable risk factors for mild cognitive impairment among cognitively normal community-dwelling older adults: A systematic review and meta-analysis	65
Computerized cognitive training in Parkinson’s disease: A systematic review and meta-analysis	64
Beyond the Hayflick limit: How microbes influence cellular aging	64
Changes in plasma phospholipids and sphingomyelins with aging in men and women: A comprehensive systematic review of longitudinal cohort studies	63
Association between pulse wave velocity and white matter hyperintensities among older adults: A meta-analysis of cross-sectional and longitudinal studies	62
The role of exercise in the prevention and treatment of Alzheimer’s disease and mild cognitive impairments	62
The effect of ferroptosis-related mitochondrial dysfunction in the development of temporal lobe epilepsy	61
Modulators of ASIC1a and its potential as a therapeutic target for age-related diseases	61
Under the umbrella of depression and Alzheimer’s disease physiopathology: Can cannabinoids be a dual-pleiotropic therapy?	59
Expanding evolutionary theories of ageing to better account for symbioses and interactions throughout the Web of Life	59
Role of Nrf2 in aging, Alzheimer’s and other neurodegenerative diseases	58
Interactions between glial cells and the blood-brain barrier and their role in Alzheimer's disease	58
Region-specific vulnerability in neurodegeneration: lessons from normal ageing	58
Association of frailty and pre-frailty with all-cause and cardiovascular mortality in diabetes: Three prospective cohorts and a meta-analysis	58
ADP-ribosylation, a multifaceted modification: Functions and mechanisms in aging and aging-related diseases	58
Affective symptoms and risk of progression to mild cognitive impairment or dementia in subjective cognitive decline: A systematic review and meta-analysis	58
Healthy brain aging and delayed dementia in Texas rural elderly	57
Targeting the gut microbiota-related metabolites for osteoporosis: The inextricable connection of gut-bone axis	57
The plasticity of fibroblasts: A forgotten player in the aging process	57
BACE1-dependent metabolism of neuregulin 1: Bridging the gap in explaining the occurrence of schizophrenia-like symptoms in Alzheimer's disease with psychosis?	56
Global burden, risk factors, and projections of early-onset dementia: Insights from the Global Burden of Disease Study 2021	56
Editorial Board	56
Is COVID-19 really a geriatric syndrome?	56
Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer’s disease: Past, present and future	56
From corpora amylacea to wasteosomes: History and perspectives	55
From onset to advancement: the temporal spectrum of α-synuclein in synucleinopathies	55
Mortality prediction models for community-dwelling older adults: A systematic review	55
Small molecule modulators of alpha-synuclein aggregation and toxicity: Pioneering an emerging arsenal against Parkinson’s disease	55
Consolidating multiple evolutionary theories of ageing suggests a need for new approaches to study genetic contributions to ageing decline	55
Association between lipocalin-2 and mild cognitive impairment or dementia: A systematic review and meta-analysis of population-based evidence	55
The metabolic and endocrine impact of diet-derived gut microbiota metabolites on ageing and longevity	54
Recent advancement in understanding of Alzheimer's disease: Risk factors, subtypes, and drug targets and potential therapeutics	54
A review on neurodegeneration in the fast-ageing killifish, the first animal model to study the natural occurrence of neuronal cell loss	54
Transposable elements and their role in aging	53
The mechanism of cuproptosis in Parkinson’s disease	53
Underserved groups in dysphagia intervention trials in Parkinson’s disease: A scoping review	53
Resolution of inflammation, an active process to restore the immune microenvironment balance: A novel drug target for treating arterial hypertension	53
Neurobiology of depression in Parkinson’s disease: Insights into epidemiology, molecular mechanisms and treatment strategies	52
Restoration of epigenetic impairment in the skeletal muscle and chronic inflammation resolution as a therapeutic approach in sarcopenia	52
Brain drug delivery and neurodegenerative diseases: Polymeric PLGA-based nanoparticles as a forefront platform	52
Alzheimer's disease and Alzheimer’s disease-related dementias in Hispanics: Identifying influential factors and supporting caregivers	52
A tale of two systems: Lessons learned from female mid-life aging with implications for Alzheimer’s prevention & treatment	52
Aryl hydrocarbon receptor (AhR) impairs circadian regulation: Impact on the aging process	51
The mechanisms of mitochondrial abnormalities that contribute to sleep disorders and related neurodegenerative diseases	51
Telomere length and brain aging: A systematic review and meta-analysis	51
Antioxidants in anti‐Alzheimer's disease drug discovery	50
Hormesis defines the limits of lifespan	50
Impact of frailty on all-cause mortality or major amputation in patients with lower extremity peripheral artery disease: A meta-analysis	49
The senotherapeutic potential of phytochemicals for age-related intestinal disease	49
Prevalence of psychotic symptoms in mild cognitive impairment: A systematic review and meta-analysis	49
Editorial Board	49
Impact of exercise intervention-based changes on physical function biomarkers in older adults after hospital discharge: A systematic review with meta-analysis of randomized clinical trials	49
Effect of ketogenic diets on insulin-like growth factor (IGF)-1 in humans: A systematic review and meta-analysis	49
Modulating α-synuclein propagation and decomposition: Implications in Parkinson's disease therapy	48
Efficacy of rehabilitation robot-assisted gait training on lower extremity dyskinesia in patients with Parkinson's disease: A systematic review and meta-analysis	48
FAM19A5 in vascular aging and osteoporosis: Mechanisms and the “calcification paradox”	48
Cerebellar pathology in forensic and clinical neuroscience	48
Single-cell sequencing insights into the transcriptional landscape of Parkinson's disease	48
Widowhood and cognitive decline in adults aged 50 and over: A systematic review and meta-analysis	47
Associations between vision impairment and eye diseases with dementia, dementia subtypes and cognitive impairment: An umbrella review	47

Epigenetic biomarkers in Alzheimer's disease: Diagnostic and prognostic relevance	47
RNA binding proteins in senescence: A potential common linker for age-related diseases?	47
Cerebral small vessel disease pathology in COVID-19 patients: A systematic review	47
Exploring Parkinson-associated kinases for CRISPR/Cas9-based gene editing: beyond alpha-synuclein	46
Blood pressure variability: A potential marker of aging	46
Breakdown of specific functional brain networks in clinical variants of Alzheimer’s disease	46
Understanding age-related pathologic changes in TDP-43 functions and the consequence on RNA splicing and signalling in health and disease	46
Glial cells in Alzheimer’s disease: From neuropathological changes to therapeutic implications	46
Biological resilience and aging: Activation of stress response pathways contributes to lifespan extension	46
Post-translational modifications: Regulators of neurodegenerative proteinopathies	46
Retinal biomarkers in Alzheimer’s disease and mild cognitive impairment: A systematic review and meta-analysis	46
The role of nutrition in inflammaging	46
Fractal dimension of the brain in neurodegenerative disease and dementia: A systematic review	45
Heat stroke: Pathogenesis, diagnosis, and current treatment	45
Neurobiological role and therapeutic potential of exercise-induced irisin in Alzheimer's disease management	44
Mitochondrial transfer between cell crosstalk – An emerging role in mitochondrial quality control	44
Osteosarcopenic adiposity (OSA) phenotype and its connection with cardiometabolic disorders: Is there a cause-and-effect?	44
Oxidative stress: The core pathogenesis and mechanism of Alzheimer’s disease	44
Is cognitive reserve associated with the prevention of cognitive decline after stroke? A Systematic review and meta-analysis	44
Editorial Board	43
Editorial Board	43
Editorial Board	43
Resolving the current controversy of use and reuse of housekeeping proteins in ageing research: Focus on saving people’s tax dollars	42
Prevalence of alcohol use among U.S. older adults with pain: A scoping review	42
Pregnancy, preeclampsia and maternal aging: From epidemiology to functional genomics	42
Towards a comprehensive framework for complex walking tasks: Characterization, behavioral adaptations, and clinical implications in ageing and neurological populations	42
Cannabidiol and neurodegeneration: From molecular mechanisms to clinical benefits	42
The interplay of NAD and hypoxic stress and its relevance for ageing	42
The prognostic impacts of frailty on clinical and patient-reported outcomes in patients undergoing coronary artery or valvular surgeries/procedures: A systematic review and meta-analysis	42
Targeting impaired nutrient sensing via the sirtuin pathway with novel compounds to prevent or treat dementia: A systematic review	42
Multi-omics research strategies in ischemic stroke: A multidimensional perspective	41
Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central nervous system	41
Osteoporosis and Alzheimer´s disease (or Alzheimer´s disease and Osteoporosis)	41
Dementia, osteoporosis and fragility fractures: Intricate epidemiological relationships, plausible biological connections, and twisted clinical practices	40
Effects of exercise interventions on cognitive functions in healthy populations: A systematic review and meta-analysis	40
Deciphering the mechanistic impact of acupuncture on the neurovascular unit in acute ischemic stroke: Insights from basic research in a narrative review	40
Adipose tissue and ovarian aging: Potential mechanism and protective strategies	40
MSC-EVs alleviate osteoarthritis by regulating microenvironmental cells in the articular cavity and maintaining cartilage matrix homeostasis	40
The role of oxidative stress in intervertebral disc degeneration: Mechanisms and therapeutic implications	39
The conceivable role of prolactin hormone in Parkinson disease: The same goal but with different ways	39
The Role of Rapamycin in Healthspan Extension via the Delay of Organ Aging	39
The role of serotonin within the microbiota-gut-brain axis in the development of Alzheimer’s disease: A narrative review	38
A cross-talk between sestrins, chronic inflammation and cellular senescence governs the development of age-associated sarcopenia and obesity	38
Emerging therapeutics agents and recent advances in drug repurposing for Alzheimer’s disease	38
Deterioration of nuclear morphology and architecture: A hallmark of senescence and aging	38
Epigenetic clock: A promising biomarker and practical tool in aging	38
Reply to “Caution in underrepresentation of older adults in clinical trials on COVID-19 vaccines”	38
Sarcopenia defined by the psoas muscle mass or quality is associated with poor survival in patients with aortic aneurysm undergoing surgery: A meta-analysis	38
Updates on brain regions and neuronal circuits of movement disorders in Parkinson’s disease	38
Editorial Board	38
Precision neurology	37
Evolving landscape of colorectal cancer: Global and regional burden, risk factor dynamics, and future scenarios (the Global Burden of Disease 1990–2050)	37
Interlinked role of ASN, TDP-43 and Miro1 with parkinopathy: Focus on targeted approach against neuropathy in parkinsonism	37
Editorial Board	37
Semaglutide as a possible therapy for healthy aging: Targeting the hallmarks of aging	37
To breathe or not to breathe: Understanding how oxygen sensing contributes to age-related phenotypes	37
Advances in human cellular mechanistic understanding and drug discovery of brain organoids for neurodegenerative diseases	36
Rebalancing the unbalanced aged immune system – A special focus on zinc	36
Motoric cognitive risk syndrome as a predictive factor of cognitive impairment and dementia – A systematic review and meta-analysis	36
Prevention of cardiovascular disease for healthy aging and longevity: A new scoring system and related “mechanisms-hallmarks-biomarkers”	36
The association of living alone and social isolation with sarcopenia: A systematic review and meta-analysis	36
Unknown roles of tau pathology in neurological disorders. Challenges and new perspectives	36
The impact of aging on HIV-1-related neurocognitive impairment	36
Harnessing two-dimensional nanomaterials for diagnosis and therapy in neurodegenerative diseases: Advances, challenges and prospects	36
The oral organ: A new vision of the mouth as a whole for a gerophysiological approach to healthy aging	35
The hallmarks of aging in Ataxia-Telangiectasia	35
Progress in the mechanisms of pain associated with neurodegenerative diseases	35
The functions and regulation of Otubains in protein homeostasis and diseases	35
Priorities in tackling noncommunicable diseases among the population aged 60 years and older in China, 1990–2021: A population-based study	35
Exploring cytokines dynamics: Uncovering therapeutic concepts for metabolic disorders in postmenopausal women- diabetes, metabolic bone diseases, and non-alcohol fatty liver disease	35
Poly (ADP-ribose) polymerase 1 and neurodegenerative diseases: Past, present, and future	34
Target modulation of glycolytic pathways as a new strategy for the treatment of neuroinflammatory diseases	34
The emerging role of exosomes in Alzheimer’s disease	34
Developing transcriptomic signatures as a biomarker of cellular senescence	34
Advancements in computer-assisted diagnosis of Alzheimer's disease: A comprehensive survey of neuroimaging methods and AI techniques for early detection	34
Immunometabolism and immune response regulate macrophage function in atherosclerosis	34
Curcumin-loaded polymeric nanomaterials as a novel therapeutic strategy for Alzheimer's disease: A comprehensive review	34
Modulating the polarization phenotype of microglia – A valuable strategy for central nervous system diseases	34
Risk factors for multimorbidity in adulthood: A systematic review	33
Inflammatory pathways in Alzheimer’s disease mediated by gut microbiota	33
Macrophage membrane-camouflaged biomimetic nanovesicles for targeted treatment of arthritis	33
Pyroptosis: Mechanisms and links with diabetic cardiomyopathy	33
Reelin links Apolipoprotein E4, Tau, and Amyloid‐β in Alzheimer’s disease	33
Is it time to revise the fighting strategy toward type 2 diabetes? Sex and pollution as new risk factors	33
Role of UCHL1 in the pathogenesis of neurodegenerative diseases and brain injury	32
Gut microbiome and Alzheimer’s disease: What we know and what remains to be explored	32
Fading memories in aging and neurodegeneration: Is p75 neurotrophin receptor a culprit?	32
Editorial Board	32
Editorial Board	32
Epigenetic enzymes: A role in aging and prospects for pharmacological targeting	32
A systematic review of the effect and mechanism of Daoyin therapy on improving mild cognitive impairment in older adults	32
Therapeutic potential of lipid nanosystems for the treatment of Parkinson’s disease	32
Sestrin2 and mitochondrial quality control: Potential impact in myogenic differentiation	32
Is exposure to pesticides associated with biological aging? A systematic review and meta-analysis	32
Unraveling the mystery of citrate transporters in Alzheimer’s disease: An updated review	31