Ageing Research Reviews

Article	Citations
Editorial Board	494
Roles of hypoxia-inducible factor-prolyl hydroxylases in aging and disease	380
Editorial Board	250
Discovery of a new hereditary RECQ helicase disorder RECON syndrome positions the replication stress response and genome homeostasis as centrally important processes in aging and age-related disease	249
The unique neuropathological vulnerability of the human brain to aging	248
Rethinking IRPs/IRE system in neurodegenerative disorders: Looking beyond iron metabolism	245
Editorial Board	232
Start the engine of neuroregeneration: A mechanistic and strategic overview of direct astrocyte-to-neuron reprogramming	217
The protein inputs of an ultra-predictive aging clock represent viable anti-aging drug targets	210
DNA methylation in genes associated with the evolution of ageing and disease: A critical review	198
Thioredoxin-1 inhibits the activation of IRE1 by targeting Hsp90/p-Cdc37 chaperone complex in Parkinson disease	193
Medication reviews in hospitalised patients for reduced hospital readmission and mortality. Systematic review, meta-analysis and meta-regression of RCTs	182
CC chemokines family in fibrosis and aging: From mechanisms to therapy	176
How good is the evidence that cellular senescence causes skin ageing?	162
Type 2 diabetes mellitus augments Parkinson’s disease risk or the other way around: Facts, challenges and future possibilities	160
Editor’s Note to “Biological constraint, evolutionary spandrels and antagonistic pleiotropy”	160
Advances in clinical application of lipidomics in healthy ageing and healthy longevity medicine	158
Sarcobesity: New paradigms for healthy aging related to taurine supplementation, gut microbiota and exercise	157
Does drug repurposing bridge the gaps in management of Parkinson’s disease? Unravelling the facts and fallacies	152
Advances in Alzheimer's therapy: Exploring neuropathological mechanisms to revolutionize the future therapeutic landscape	145
Prevalence and health outcomes of polypharmacy and hyperpolypharmacy in older adults with frailty: A systematic review and meta-analysis	144
Efficacy of technology-based cognitive and exercise interventions for mild cognitive impairment: A systematic review, network meta-analysis, and meta-regression of randomized controlled trials	143
Effectiveness of virtual reality interventions on quality of life, cognitive function and physical function in older people with Alzheimer's disease: A systematic review	139
Histopathological and ultrastructural changes in different cell types during ischemic and hemorrhagic stroke	139
Unravelling the brain resilience following stroke: From injury to rewiring of the brain through pathway activation, drug targets, and therapeutic interventions	131

Updated systematic review and meta-analysis on diagnostic issues and the prognostic impact of myosteatosis: A new paradigm beyond sarcopenia	131
Unraveling the protein post-translational modification landscape: Neuroinflammation and neuronal death after stroke	131
The functions of IRE1α in neurodegenerative diseases: Beyond ER stress	123
Artificial intelligence in brain MRI analysis of Alzheimer’s disease over the past 12 years: A systematic review	119
Repetitive transcranial magnetic stimulation combined with cognitive training for cognitive function and activities of daily living in patients with post-stroke cognitive impairment: A systematic revi	117
miR-21 and miR-146a: The microRNAs of inflammaging and age-related diseases	116
Adenosine metabolism and receptors in aging of the skin, musculoskeletal, immune and cardiovascular systems	113
Optimal dose and type of exercise to improve cognitive function in older adults: A systematic review and bayesian model-based network meta-analysis of RCTs	113
Vascular cognitive impairment – Past, present, and future challenges	112
Microglia and gut microbiota: A double-edged sword in Alzheimer's disease	111
Dysfunction of norepinephrine and its metabolites in Alzheimer's dementia – A review with meta-analysis	111
Can dementia risk be reduced by following the American Heart Association's Life's Simple 7? A systematic review and dose-response meta-analysis	110
The several ways to authentically cure Alzheimer’s dementia	110
Global, regional, and national burden of spinal cord injury from 1990 to 2021 and projections for 2050: A systematic analysis for the Global Burden of Disease 2021 study	110
Cognitive resilience in Alzheimer’s disease: Mechanism and potential clinical intervention	107
Neuroprotection by agmatine: Possible involvement of the gut microbiome?	106
Cytosolic DNA sensor IFI16 proteins: Potential molecular integrators of interactions among the aging hallmarks	105
Sensory nerve regulation of bone homeostasis: Emerging therapeutic opportunities for bone-related diseases	104
Triaging between post-translational modification of cell cycle regulators and their therapeutics in neurodegenerative diseases	103
The role of the PLA2G6 gene in neurodegenerative diseases	101
Associations of olfactory function with brain structural and functional outcomes. A systematic review	100
Interventions to prevent and treat delirium: An umbrella review of randomized controlled trials	98
Biomarkers associated with cognitive impairment in post-traumatic stress disorder: A systematic review of current evidence	98
Involvement of regulated cell deaths in aging and age-related pathologies	97
Targeting immune dysfunction in aging	93
Overview of pro-inflammatory and pro-survival components in neuroinflammatory signalling and neurodegeneration	93
New era of artificial intelligence and machine learning-based detection, diagnosis, and therapeutics in Parkinson’s disease	92
Searching for the link between inflammaging and sarcopenia	92
Advances of artificial intelligence in predicting frailty using real-world data: A scoping review	91
The effectiveness of dance movement interventions for older adults with mild cognitive impairment, Alzheimer’s disease, and dementia: A systematic scoping review and meta-analysis	89
Melatonin: Potential avenue for treating iron overload disorders	89
Hallmarks of aging: A user’s guide for comparative biologists	86
A Multimodal Meta-Analytical Evidence of Functional and Structural Brain Abnormalities Across Alzheimer's Disease Spectrum	85
Transcranial direct current stimulation combined with motor training for motor symptoms in Parkinson's disease: A systematic review and meta-analysis	85
Research progress in Alzheimer's disease and bone-brain axis	85
On the wake of metformin: Do anti-diabetic SGLT2 inhibitors exert anti-aging effects?	84
Characterization of the logopenic variant of Primary Progressive Aphasia: A systematic review and meta-analysis	83
The mitochondrial integrated stress response: A novel approach to anti-aging and pro-longevity	83
Bridging neurotrophic factors and bioactive peptides to Alzheimer's disease	82
Cross-sectional and longitudinal associations between adherence to Mediterranean diet with physical performance and cognitive function in older adults: A systematic review and meta-analysis	81
Exercise training increases telomerase reverse transcriptase gene expression and telomerase activity: A systematic review and meta-analysis	80
Role of diet and exercise in aging, Alzheimer’s disease, and other chronic diseases	80
Potential convergence of olfactory dysfunction in Parkinson’s disease and COVID-19: The role of neuroinflammation	79
Betaine and aging: A narrative review of findings, possible mechanisms, research perspectives, and practical recommendations	79
HMGB1, an evolving pleiotropic protein critical for cellular and tissue homeostasis: Role in aging and age-related diseases	78
The link between metabolic syndrome and Alzheimer disease: A mutual relationship and long rigorous investigation	78
Adherence to the Mediterranean diet and risk of frailty and pre-frailty in elderly adults: A systematic review and dose-response meta-analysis with GRADE assessment	77
Targeting aging with urolithin A in humans: A systematic review	77
Identification of exosomal biomarkers and its optimal isolation and detection method for the diagnosis of Parkinson's disease: A systematic review and meta-analysis	76
Modifiable lifestyle factors and cognitive reserve: A systematic review of current evidence	75

Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseases	75
Latest developments of microphysiological systems (MPS) in aging-related and geriatric diseases research: A review	74
Current research status of blood biomarkers in Alzheimer’s disease: Diagnosis and prognosis	72
A novel regulator in Alzheimer's disease progression: The astrocyte-derived extracellular vesicles	71
ADP-ribosylation, a multifaceted modification: Functions and mechanisms in aging and aging-related diseases	71
Oral health indicators and bone mineral density disorders in older age: A systematic review	70
Healthy brain aging and delayed dementia in Texas rural elderly	70
Association of frailty and pre-frailty with all-cause and cardiovascular mortality in diabetes: Three prospective cohorts and a meta-analysis	70
Modulators of ASIC1a and its potential as a therapeutic target for age-related diseases	69
Turquoise killifish: A natural model of age-dependent brain degeneration	69
Affective symptoms and risk of progression to mild cognitive impairment or dementia in subjective cognitive decline: A systematic review and meta-analysis	69
Expanding evolutionary theories of ageing to better account for symbioses and interactions throughout the Web of Life	69
A critical appraisal of blood-based biomarkers for Alzheimer’s disease	68
The effect of ferroptosis-related mitochondrial dysfunction in the development of temporal lobe epilepsy	68
Unravelling of molecular biomarkers in synaptic plasticity of Alzheimer’s disease: Critical role of the restoration of neuronal circuits	68
Suicide and dementia: A systematic review and meta-analysis of prevalence and risk factors	68
Interactions between glial cells and the blood-brain barrier and their role in Alzheimer's disease	67
The role of exercise in the prevention and treatment of Alzheimer’s disease and mild cognitive impairments	67
Genetic mechanisms of aging in plants: What can we learn from them?	67
cGAS-STING targeting offers novel therapeutic opportunities in neurological diseases	67
Association between pulse wave velocity and white matter hyperintensities among older adults: A meta-analysis of cross-sectional and longitudinal studies	66
The future of stem cell therapies of Alzheimer’s disease	66
Computerized cognitive training in Parkinson’s disease: A systematic review and meta-analysis	66
Modifiable risk factors for mild cognitive impairment among cognitively normal community-dwelling older adults: A systematic review and meta-analysis	65
Regulated cell death in acute myocardial infarction: Molecular mechanisms and therapeutic implications	65
Molecular hydrogen therapy: A “democratic” emerging strategy against aging and age-related diseases	65
Drug repositioning for Parkinson’s disease: An emphasis on artificial intelligence approaches	65
Long-term human spaceflight and inflammaging: Does it promote aging?	64
Exercise interventions in Alzheimer’s disease: A systematic review and meta-analysis of randomized controlled trials	64
Targeting the gut microbiota-related metabolites for osteoporosis: The inextricable connection of gut-bone axis	64
Role of Nrf2 in aging, Alzheimer’s and other neurodegenerative diseases	63
Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer’s disease: Past, present and future	63
Intracellular effects of lithium in aging neurons	62
The cross-talk between the cGAS-STING signaling pathway and chronic inflammation in the development of musculoskeletal disorders	62
Beyond the Hayflick limit: How microbes influence cellular aging	62
Dissecting primary and secondary senescence to enable new senotherapeutic strategies	61
Aryl hydrocarbon receptor: From pathogenesis to therapeutic targets in aging-related tissue fibrosis	61
The plasticity of fibroblasts: A forgotten player in the aging process	61
Under the umbrella of depression and Alzheimer’s disease physiopathology: Can cannabinoids be a dual-pleiotropic therapy?	61
Biological constraint, evolutionary spandrels and antagonistic pleiotropy	61
Is COVID-19 really a geriatric syndrome?	60
Editorial Board	60
The mechanisms of mitochondrial abnormalities that contribute to sleep disorders and related neurodegenerative diseases	59
BACE1-dependent metabolism of neuregulin 1: Bridging the gap in explaining the occurrence of schizophrenia-like symptoms in Alzheimer's disease with psychosis?	59
A review on neurodegeneration in the fast-ageing killifish, the first animal model to study the natural occurrence of neuronal cell loss	59
Antioxidants in anti‐Alzheimer's disease drug discovery	59
Resolution of inflammation, an active process to restore the immune microenvironment balance: A novel drug target for treating arterial hypertension	59
Small molecule modulators of alpha-synuclein aggregation and toxicity: Pioneering an emerging arsenal against Parkinson’s disease	58
Mortality prediction models for community-dwelling older adults: A systematic review	58
Underserved groups in dysphagia intervention trials in Parkinson’s disease: A scoping review	58
Unlocking the potential of histone deacetylase inhibitors in combatting age-related retinal degenerative diseases	57
The memory- and cognition-facilitating effects of spermidine in aging and aging-related disorders	57
Alzheimer's disease and Alzheimer’s disease-related dementias in Hispanics: Identifying influential factors and supporting caregivers	57
Recent advancement in understanding of Alzheimer's disease: Risk factors, subtypes, and drug targets and potential therapeutics	56
From corpora amylacea to wasteosomes: History and perspectives	56
Restoration of epigenetic impairment in the skeletal muscle and chronic inflammation resolution as a therapeutic approach in sarcopenia	56
Global burden, risk factors, and projections of early-onset dementia: Insights from the Global Burden of Disease Study 2021	56
Telomere length and brain aging: A systematic review and meta-analysis	56
From onset to advancement: the temporal spectrum of α-synuclein in synucleinopathies	56
Association between lipocalin-2 and mild cognitive impairment or dementia: A systematic review and meta-analysis of population-based evidence	55
Brain drug delivery and neurodegenerative diseases: Polymeric PLGA-based nanoparticles as a forefront platform	55
Transposable elements and their role in aging	54
A tale of two systems: Lessons learned from female mid-life aging with implications for Alzheimer’s prevention & treatment	54
The metabolic and endocrine impact of diet-derived gut microbiota metabolites on ageing and longevity	53
Aryl hydrocarbon receptor (AhR) impairs circadian regulation: Impact on the aging process	53
Editorial Board	53
The mechanism of cuproptosis in Parkinson’s disease	53
Hormesis defines the limits of lifespan	53
Neurobiology of depression in Parkinson’s disease: Insights into epidemiology, molecular mechanisms and treatment strategies	53
Consolidating multiple evolutionary theories of ageing suggests a need for new approaches to study genetic contributions to ageing decline	53
Exploring Parkinson-associated kinases for CRISPR/Cas9-based gene editing: beyond alpha-synuclein	52
Fractal dimension of the brain in neurodegenerative disease and dementia: A systematic review	52
Cerebral small vessel disease pathology in COVID-19 patients: A systematic review	51
Breakdown of specific functional brain networks in clinical variants of Alzheimer’s disease	51
Effect of ketogenic diets on insulin-like growth factor (IGF)-1 in humans: A systematic review and meta-analysis	51
Modulating α-synuclein propagation and decomposition: Implications in Parkinson's disease therapy	51
Impact of frailty on all-cause mortality or major amputation in patients with lower extremity peripheral artery disease: A meta-analysis	51
RNA binding proteins in senescence: A potential common linker for age-related diseases?	51
Efficacy of rehabilitation robot-assisted gait training on lower extremity dyskinesia in patients with Parkinson's disease: A systematic review and meta-analysis	50
FAM19A5 in vascular aging and osteoporosis: Mechanisms and the “calcification paradox”	50

Impact of exercise intervention-based changes on physical function biomarkers in older adults after hospital discharge: A systematic review with meta-analysis of randomized clinical trials	50
Single-cell sequencing insights into the transcriptional landscape of Parkinson's disease	50
Cerebellar pathology in forensic and clinical neuroscience	50
Long-term fasting and its influence on inflammatory biomarkers: A comprehensive scoping review	49
Epigenetic biomarkers in Alzheimer's disease: Diagnostic and prognostic relevance	49
Associations between vision impairment and eye diseases with dementia, dementia subtypes and cognitive impairment: An umbrella review	49
Multi-omics strategies to decode the molecular landscape of cellular senescence	49
The senotherapeutic potential of phytochemicals for age-related intestinal disease	49
Prevalence of psychotic symptoms in mild cognitive impairment: A systematic review and meta-analysis	48
Understanding age-related pathologic changes in TDP-43 functions and the consequence on RNA splicing and signalling in health and disease	48
Widowhood and cognitive decline in adults aged 50 and over: A systematic review and meta-analysis	48
Biological resilience and aging: Activation of stress response pathways contributes to lifespan extension	48
Blood pressure variability: A potential marker of aging	48
Glial cells in Alzheimer’s disease: From neuropathological changes to therapeutic implications	47
Mitochondrial transfer between cell crosstalk – An emerging role in mitochondrial quality control	47
Heat stroke: Pathogenesis, diagnosis, and current treatment	47
Editorial Board	46
Oxidative stress: The core pathogenesis and mechanism of Alzheimer’s disease	46
The conceivable role of prolactin hormone in Parkinson disease: The same goal but with different ways	46
Editorial Board	46
Resolving the current controversy of use and reuse of housekeeping proteins in ageing research: Focus on saving people’s tax dollars	46
Editorial Board	46
The role of nutrition in inflammaging	46
Osteosarcopenic adiposity (OSA) phenotype and its connection with cardiometabolic disorders: Is there a cause-and-effect?	46
Multi-omics research strategies in ischemic stroke: A multidimensional perspective	45
Markers of biological age in dogs	45
The prognostic impacts of frailty on clinical and patient-reported outcomes in patients undergoing coronary artery or valvular surgeries/procedures: A systematic review and meta-analysis	45
Neurobiological role and therapeutic potential of exercise-induced irisin in Alzheimer's disease management	45
Dementia, osteoporosis and fragility fractures: Intricate epidemiological relationships, plausible biological connections, and twisted clinical practices	45
The role of serotonin within the microbiota-gut-brain axis in the development of Alzheimer’s disease: A narrative review	44
Cannabidiol and neurodegeneration: From molecular mechanisms to clinical benefits	44
Targeting impaired nutrient sensing via the sirtuin pathway with novel compounds to prevent or treat dementia: A systematic review	44
Updates on brain regions and neuronal circuits of movement disorders in Parkinson’s disease	44
The interplay of NAD and hypoxic stress and its relevance for ageing	44
Prevalence of alcohol use among U.S. older adults with pain: A scoping review	44
The Role of Rapamycin in Healthspan Extension via the Delay of Organ Aging	43
A cross-talk between sestrins, chronic inflammation and cellular senescence governs the development of age-associated sarcopenia and obesity	43
Osteoporosis and Alzheimer´s disease (or Alzheimer´s disease and Osteoporosis)	43
Adipose tissue and ovarian aging: Potential mechanism and protective strategies	43
MSC-EVs alleviate osteoarthritis by regulating microenvironmental cells in the articular cavity and maintaining cartilage matrix homeostasis	43
Is cognitive reserve associated with the prevention of cognitive decline after stroke? A Systematic review and meta-analysis	43
Deciphering the mechanistic impact of acupuncture on the neurovascular unit in acute ischemic stroke: Insights from basic research in a narrative review	43
Effects of exercise interventions on cognitive functions in healthy populations: A systematic review and meta-analysis	43
Reply to “Caution in underrepresentation of older adults in clinical trials on COVID-19 vaccines”	42
Epigenetic clock: A promising biomarker and practical tool in aging	42
Pregnancy, preeclampsia and maternal aging: From epidemiology to functional genomics	42
The role of oxidative stress in intervertebral disc degeneration: Mechanisms and therapeutic implications	42
Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central nervous system	42
Towards a comprehensive framework for complex walking tasks: Characterization, behavioral adaptations, and clinical implications in ageing and neurological populations	42
The association of living alone and social isolation with sarcopenia: A systematic review and meta-analysis	41
Exerkines: Potential regulators of diabetic cardiomyopathy	41
The hallmarks of aging in Ataxia-Telangiectasia	40
Precision neurology	40
The impact of aging on HIV-1-related neurocognitive impairment	40
Advancements in computer-assisted diagnosis of Alzheimer's disease: A comprehensive survey of neuroimaging methods and AI techniques for early detection	40
Advances in human cellular mechanistic understanding and drug discovery of brain organoids for neurodegenerative diseases	40
Semaglutide as a possible therapy for healthy aging: Targeting the hallmarks of aging	39
Harnessing two-dimensional nanomaterials for diagnosis and therapy in neurodegenerative diseases: Advances, challenges and prospects	39
Reducing Alzheimer’s disease risk with SGLT2 inhibitors: From glycemic control to neuroprotection	39
Interlinked role of ASN, TDP-43 and Miro1 with parkinopathy: Focus on targeted approach against neuropathy in parkinsonism	39
Editorial Board	39
Editorial Board	39
Is it time to revise the fighting strategy toward type 2 diabetes? Sex and pollution as new risk factors	38
The oral organ: A new vision of the mouth as a whole for a gerophysiological approach to healthy aging	38
Progress in the mechanisms of pain associated with neurodegenerative diseases	38
Gut microbiome and Alzheimer’s disease: What we know and what remains to be explored	38
Emerging therapeutics agents and recent advances in drug repurposing for Alzheimer’s disease	38
Unknown roles of tau pathology in neurological disorders. Challenges and new perspectives	37
Reelin links Apolipoprotein E4, Tau, and Amyloid‐β in Alzheimer’s disease	37
Developing transcriptomic signatures as a biomarker of cellular senescence	37
Immersive virtual reality for older adults: Challenges and solutions in basic research and clinical applications	37
Target modulation of glycolytic pathways as a new strategy for the treatment of neuroinflammatory diseases	37
Poly (ADP-ribose) polymerase 1 and neurodegenerative diseases: Past, present, and future	37
Prevention of cardiovascular disease for healthy aging and longevity: A new scoring system and related “mechanisms-hallmarks-biomarkers”	37
Priorities in tackling noncommunicable diseases among the population aged 60 years and older in China, 1990–2021: A population-based study	37
Role of UCHL1 in the pathogenesis of neurodegenerative diseases and brain injury	37
Sarcopenia defined by the psoas muscle mass or quality is associated with poor survival in patients with aortic aneurysm undergoing surgery: A meta-analysis	36
Evolving landscape of colorectal cancer: Global and regional burden, risk factor dynamics, and future scenarios (the Global Burden of Disease 1990–2050)	36
Mapping the immune-genetic architecture of aging: A single-cell causal framework for biomarker discovery and therapeutic targeting	36
Rebalancing the unbalanced aged immune system – A special focus on zinc	36
Therapeutic potential of lipid nanosystems for the treatment of Parkinson’s disease	36
Motoric cognitive risk syndrome as a predictive factor of cognitive impairment and dementia – A systematic review and meta-analysis	36
Exploring cytokines dynamics: Uncovering therapeutic concepts for metabolic disorders in postmenopausal women- diabetes, metabolic bone diseases, and non-alcohol fatty liver disease	36
Definitions of healthspan: A systematic review	35
Macrophage membrane-camouflaged biomimetic nanovesicles for targeted treatment of arthritis	35
Pyroptosis: Mechanisms and links with diabetic cardiomyopathy	35
Curcumin-loaded polymeric nanomaterials as a novel therapeutic strategy for Alzheimer's disease: A comprehensive review	34
Risk factors for multimorbidity in adulthood: A systematic review	34
Immunometabolism and immune response regulate macrophage function in atherosclerosis	34
Modulating the polarization phenotype of microglia – A valuable strategy for central nervous system diseases	34
Pancreatic β-cell remodeling in health and aging: Lessons from rodents and humans	33
Inflamm-aging as a diverse and context-dependent process: from species and population differences to individual trajectories	33
The beneficial effects of mesenchymal stem cells and their exosomes on myocardial infarction and critical considerations for enhancing their efficacy	33
A systematic review of the effect and mechanism of Daoyin therapy on improving mild cognitive impairment in older adults	33
Effectiveness and safety of Governor vessel acupuncture therapy for post-stroke cognitive impairment: A meta-analysis of randomized controlled trials	33