Ageing Research Reviews

Article	Citations
Comparison between frail and non-frail older adults’ gut microbiota: A systematic review and meta-analysis	691
Prevalence of radicular neuropathic pain in idiopathic Parkinson’s disease: A systematic review and meta-analysis	363
Research progress in the molecular mechanism of ferroptosis in Parkinson's disease and regulation by natural plant products	323
Passive Alzheimer’s immunotherapy: A promising or uncertain option?	300
Endothelial cell senescence: A machine learning-based meta-analysis of transcriptomic studies	263
Advances in clinical application of lipidomics in healthy ageing and healthy longevity medicine	229
Tau internalization: A complex step in tau propagation	224
Type 2 diabetes mellitus augments Parkinson’s disease risk or the other way around: Facts, challenges and future possibilities	210
Bridging geriatric medicine, clinical pharmacology and ageing biology to understand and improve outcomes of medicines in old age and frailty	187
DNA methylation in genes associated with the evolution of ageing and disease: A critical review	181
Restoring the oxidative balance in age-related diseases – An approach in glaucoma	170
Editorial Board	169
Discovery of a new hereditary RECQ helicase disorder RECON syndrome positions the replication stress response and genome homeostasis as centrally important processes in aging and age-related disease	169
Editorial Board	168
Effects of tart cherry and its metabolites on aging and inflammatory conditions: Efficacy and possible mechanisms	165
Dysfunction of norepinephrine and its metabolites in Alzheimer's dementia – A review with meta-analysis	159
Interlinked role of ASN, TDP-43 and Miro1 with parkinopathy: Focus on targeted approach against neuropathy in parkinsonism	151
Psychometric characteristics of comprehensive geriatric assessments (CGAs) for long-term care facilities and community care: A systematic review	148
Editorial Board	144
Balance-based exercise programs on balance in older adults with mild to moderate dementia: A critically appraised topic	140
Editorial Board	134
Pyroptosis: Mechanisms and links with diabetic cardiomyopathy	123
Universal masking during COVID-19 outbreaks in aged care settings: A systematic review and meta-analysis	122
Harnessing two-dimensional nanomaterials for diagnosis and therapy in neurodegenerative diseases: Advances, challenges and prospects	119
Editorial Board	118

Association of F2-isoprostane levels with Alzheimer’s disease in observational studies: A systematic review and meta-analysis	117
Editorial Board	113
Editorial Board	110
Reply to “Caution in underrepresentation of older adults in clinical trials on COVID-19 vaccines”	109
The oral organ: A new vision of the mouth as a whole for a gerophysiological approach to healthy aging	109
Transcranial magnetic stimulation (TMS) for geriatric depression	108
Modulation of cholesterol metabolism with Phytoremedies in Alzheimer’s disease: A comprehensive review	107
Interspecific interactions that affect ageing: Age-distorters manipulate host ageing to their own evolutionary benefits	106
Determining the cortical, spinal and muscular adaptations to strength-training in older adults: A systematic review and meta-analysis	101
COVID-19 mortality as a fingerprint of biological age	100
Reelin links Apolipoprotein E4, Tau, and Amyloid‐β in Alzheimer’s disease	99
Pharmaceutical and nutraceutical activation of FOXO3 for healthy longevity	97
Caenorhabditis elegans: A transgenic model for studying age-associated neurodegenerative diseases	95
Modulating the polarization phenotype of microglia – A valuable strategy for central nervous system diseases	92
The protein inputs of an ultra-predictive aging clock represent viable anti-aging drug targets	91
Neolignans in Magnolia officinalis as natural anti-Alzheimer’s disease agents: A systematic review	90
Is it time to revise the fighting strategy toward type 2 diabetes? Sex and pollution as new risk factors	89
Constituent isoflavones of Puerariae radix as a potential neuroprotector in cognitive impairment: Evidence from preclinical studies	88
Immunometabolism and immune response regulate macrophage function in atherosclerosis	88
Determinants of approved acetylcholinesterase inhibitor response outcomes in Alzheimer’s disease: relevance for precision medicine in neurodegenerative diseases	87
Developing transcriptomic signatures as a biomarker of cellular senescence	87
Can extracellular vesicles be considered as a potential frontier in the treatment of intervertebral disc disease?	86
Neuroenergetic alterations in neurodegenerative diseases: A systematic review and meta-analysis of in vivo 31P-MRS studies	83
Sarcobesity: New paradigms for healthy aging related to taurine supplementation, gut microbiota and exercise	83
Unraveling the protein post-translational modification landscape: Neuroinflammation and neuronal death after stroke	83
The emerging role of exercise in Alzheimer’s disease: Focus on mitochondrial function	82
Sex difference, proteostasis and mitochondrial function impact stroke-related sarcopenia—A systematic review and meta-analysis	79
Target modulation of glycolytic pathways as a new strategy for the treatment of neuroinflammatory diseases	79
Motoric cognitive risk syndrome as a predictive factor of cognitive impairment and dementia – A systematic review and meta-analysis	78
Exploring cytokines dynamics: Uncovering therapeutic concepts for metabolic disorders in postmenopausal women- diabetes, metabolic bone diseases, and non-alcohol fatty liver disease	77
Risk factors for multimorbidity in adulthood: A systematic review	76
Pangenomics: A new era in the field of neurodegenerative diseases	76
Obesity-induced neuronal senescence: Unraveling the pathophysiological links	76
Lifestyle strategies to promote proteostasis and reduce the risk of Alzheimer’s disease and other proteinopathies	75
Prediction models for depression risk among older adults: systematic review and critical appraisal	74
Pasteurized non-fermented cow’s milk but not fermented milk is a promoter of mTORC1-driven aging and increased mortality	73
A review of dementia, focusing on the distinct roles of viral protein corona and MMP9 in dementia: Potential pharmacotherapeutic priorities	72
Sarcopenia defined by the psoas muscle mass or quality is associated with poor survival in patients with aortic aneurysm undergoing surgery: A meta-analysis	72
Apathy in Alzheimer’s disease: A neurocircuitry based perspective	70
Machine learning in Alzheimer’s disease drug discovery and target identification	68
Recent advances in the field of caloric restriction mimetics and anti-aging molecules	68
The association of living alone and social isolation with sarcopenia: A systematic review and meta-analysis	67
Genetic aberration analysis of mitochondrial respiratory complex I implications in the development of neurological disorders and their clinical significance	67
The functions of IRE1α in neurodegenerative diseases: Beyond ER stress	66
Systematic analysis of nutrigenomic effects of polyphenols related to cardiometabolic health in humans – Evidence from untargeted mRNA and miRNA studies	66
Senescence in tissue samples of humans with age-related diseases: A systematic review	64
From biological aging to functional decline: Insights into chronic inflammation and intrinsic capacity	64
Updated systematic review and meta-analysis on diagnostic issues and the prognostic impact of myosteatosis: A new paradigm beyond sarcopenia	63
Biomarkers used in Alzheimer’s disease diagnosis, treatment, and prevention	63
How good is the evidence that cellular senescence causes skin ageing?	63

Combined physical and cognitive training for older adults with and without cognitive impairment: A systematic review and network meta-analysis of randomized controlled trials	62
Beyond cardiovascular risk: Implications of Familial hypercholesterolemia on cognition and brain function	61
Stepping impairment and falls in older adults: A systematic review and meta-analysis of volitional and reactive step tests	60
Types of exercise and training duration on depressive symptoms among older adults in long-term care facilities	60
Bio-enhanced fraction from Clitoria ternatea root extract ameliorates cognitive functions and in vivo hippocampal neuroplasticity in chronic cerebral hypoperfusion rat model	58
Frailty in rodents: Models, underlying mechanisms, and management	58
Macrophage membrane-camouflaged biomimetic nanovesicles for targeted treatment of arthritis	58
Therapeutic potential of lipid nanosystems for the treatment of Parkinson’s disease	58
Risk of seizures and subclinical epileptiform activity in patients with dementia: A systematic review and meta-analysis	57
The retina: A window in which to view the pathogenesis of Alzheimer’s disease	56
Advancements in computer-assisted diagnosis of Alzheimer's disease: A comprehensive survey of neuroimaging methods and AI techniques for early detection	54
Prevalence and health outcomes of polypharmacy and hyperpolypharmacy in older adults with frailty: A systematic review and meta-analysis	54
Exploring the conceptual framework and measurement model of intrinsic capacity defined by the World Health Organization: A scoping review	54
The emerging role of exosomes in Alzheimer’s disease	54
Immunity orchestrates a bridge in gut-brain axis of neurodegenerative diseases	54
Autophagy in aging-related diseases and cancer: Principles, regulatory mechanisms and therapeutic potential	54
Emerging therapeutics agents and recent advances in drug repurposing for Alzheimer’s disease	54
Mesencephalic astrocyte-derived neurotrophic factor (MANF): Structure, functions and therapeutic potential	53
Advancing the understanding of diabetic encephalopathy through unravelling pathogenesis and exploring future treatment perspectives	53
Can dementia risk be reduced by following the American Heart Association's Life's Simple 7? A systematic review and dose-response meta-analysis	53
Does personality affect the cognitive decline in aging? A systematic review	52
Efficacy of technology-based cognitive and exercise interventions for mild cognitive impairment: A systematic review, network meta-analysis, and meta-regression of randomized controlled trials	52
Mechanism and therapeutic targets of the involvement of a novel lysosomal proton channel TMEM175 in Parkinson's disease	51
Effects of interventions on cerebral perfusion in the Alzheimer's disease spectrum: A systematic review	51
The unique neuropathological vulnerability of the human brain to aging	51
Potential mechanisms underlying the accelerated cognitive decline in people with chronic low back pain: A scoping review	50
The underlying roles and neurobiological mechanisms of music-based intervention in Alzheimer's disease: A comprehensive review	50
Spatial omics: An innovative frontier in aging research	49
CC chemokines family in fibrosis and aging: From mechanisms to therapy	49
Improving geriatric outcomes through nutritional and immunonutritional strategies: Focus on surgical setting by a comprehensive evidence review	49
Multiomics insights into the female reproductive aging	49
A new face of old cells: An overview about the role of senescence and telomeres in inflammatory bowel diseases	49
MicroRNAs in the regulation of autophagy and their possible use in age-related macular degeneration therapy	49
Sirtuins, resveratrol and the intertwining cellular pathways connecting them	48
Role of enteric glia and microbiota-gut-brain axis in parkinson disease pathogenesis	47
p62 works as a hub modulation in the ageing process	47
Innovative approaches to Alzheimer's therapy: Harnessing the power of heterocycles, oxidative stress management, and nanomaterial drug delivery system	46
Novel fluid biomarkers for mild cognitive impairment: A systematic review and meta-analysis	46
Rethinking IRPs/IRE system in neurodegenerative disorders: Looking beyond iron metabolism	45
Development of nanomedicines for the treatment of Alzheimer’s disease: Raison d’être, strategies, challenges and regulatory aspects	45
Repetitive transcranial magnetic stimulation combined with cognitive training for cognitive function and activities of daily living in patients with post-stroke cognitive impairment: A systematic revi	45
Redox imbalance in age-related ovarian dysfunction and perspectives for its prevention	44
CXCL12/CXCR4: An amazing challenge and opportunity in the fight against fibrosis	44
Curcumin nanoformulations to combat aging-related diseases	44
Inflammatory pathways in Alzheimer’s disease mediated by gut microbiota	44
Thioredoxin-1 inhibits the activation of IRE1 by targeting Hsp90/p-Cdc37 chaperone complex in Parkinson disease	44
Artificial intelligence in brain MRI analysis of Alzheimer’s disease over the past 12 years: A systematic review	43
Socially assistive robots for people with dementia: Systematic review and meta-analysis of feasibility, acceptability and the effect on cognition, neuropsychiatric symptoms and quality of life	43
Relationship between obesity and structural brain abnormality: Accumulated evidence from observational studies	43
The roles of the Hippo-YAP signalling pathway in Cartilage and Osteoarthritis	42
Oxidative stress and antioxidant defenses in mild cognitive impairment: A systematic review and meta-analysis	42
Beta-adrenergic drugs and risk of Parkinson’s disease: A systematic review and meta-analysis	42
Rebalancing the unbalanced aged immune system – A special focus on zinc	42
Research progress on the effects of novel hypoglycemic drugs in diabetes combined with myocardial ischemia/reperfusion injury	41
Energy metabolism and frailty: The potential role of exercise-induced myokines – A narrative review	41
Frailty and pain, human studies and animal models	41
Evolving therapeutic interventions for the management and treatment of Alzheimer’s disease	41
Is personality associated with dementia risk? A meta-analytic investigation	41
Psychedelics for alzheimer's disease-related dementia: Unveiling therapeutic possibilities and pathways	41
Poly (ADP-ribose) polymerase 1 and neurodegenerative diseases: Past, present, and future	40
Novel target for treating Alzheimer’s Diseases: Crosstalk between the Nrf2 pathway and autophagy	40
Deregulated mitochondrial microRNAs in Alzheimer's disease: Focus on synapse and mitochondria	40
Stress, diet, exercise: Common environmental factors and their impact on epigenetic age	40
Prevalence of multidimensional frailty and pre-frailty in older people in different settings: A systematic review and meta-analysis	40
Hypoxia and hemorheological properties in older individuals	39
Optimal dose and type of exercise to improve cognitive function in older adults: A systematic review and bayesian model-based network meta-analysis of RCTs	39
Fungi as a source of bioactive molecules for the development of longevity medicines	39
The hallmarks of aging in Ataxia-Telangiectasia	39
Principles of brain aging: Status and challenges of modeling human molecular changes in mice	39
To breathe or not to breathe: Understanding how oxygen sensing contributes to age-related phenotypes	38
The role of Nrf2 in neural stem/progenitors cells: From maintaining stemness and self-renewal to promoting differentiation capability and facilitating therapeutic application in neurodegenerative dise	38
Senescent cells as promising targets to tackle age-related diseases	38
The functions and regulation of Otubains in protein homeostasis and diseases	38
miR-21 and miR-146a: The microRNAs of inflammaging and age-related diseases	37
Sex biology in amyotrophic lateral sclerosis	37
Adult-onset hearing loss and incident cognitive impairment and dementia – A systematic review and meta-analysis of cohort studies	37
The classical and non-classical axes of renin-angiotensin system in Parkinson disease: The bright and dark side of the moon	37
Calprotectin in Parkinsonian disease: Anticipation and dedication	37
Semaglutide as a possible therapy for healthy aging: Targeting the hallmarks of aging	36
Mitochondria break free: Mitochondria-derived vesicles in aging and associated conditions	36

Progress in the mechanisms of pain associated with neurodegenerative diseases	36
Priorities in tackling noncommunicable diseases among the population aged 60 years and older in China, 1990–2021: A population-based study	36
The impact of aging on HIV-1-related neurocognitive impairment	35
Ageing, proteostasis, and the gut: Insights into neurological health and disease	35
Advances in human cellular mechanistic understanding and drug discovery of brain organoids for neurodegenerative diseases	35
Breaking new ground on human health and well-being with epigenetic clocks: A systematic review and meta-analysis of epigenetic age acceleration associations	35
Roles of hypoxia-inducible factor-prolyl hydroxylases in aging and disease	35
Editorial Board	35
Structural and physiological changes of the kidney with age and its impact on chronic conditions and COVID-19	34
Regulation of DNA damage response by RNA/DNA-binding proteins: Implications for neurological disorders and aging	34
Disease-modifying therapies for Alzheimer’s disease: Clinical trial progress and opportunity	34
Exercise-induced adaptive response of different immune organs during ageing	34
Gut microbiome and Alzheimer’s disease: What we know and what remains to be explored	33
Role of UCHL1 in the pathogenesis of neurodegenerative diseases and brain injury	33
Global, regional, and national burden of spinal cord injury from 1990 to 2021 and projections for 2050: A systematic analysis for the Global Burden of Disease 2021 study	33
Microglia and gut microbiota: A double-edged sword in Alzheimer's disease	33
The accelerated aging phenotype: The role of race and social determinants of health on aging	33
Passive immunotherapy for Alzheimer's disease	33
Unknown roles of tau pathology in neurological disorders. Challenges and new perspectives	33
Associations between social health factors, cognitive activity and neurostructural markers for brain health – A systematic literature review and meta-analysis	32
Vascular dementia: A microglia's perspective	32
Vascular cognitive impairment – Past, present, and future challenges	32
Short-chain fatty acid metabolism and multiple effects on cardiovascular diseases	32
Mitochondrial dysfunction in aging	32
Past, present and future of therapeutic strategies against amyloid-β peptides in Alzheimer’s disease: a systematic review	31
Curcumin-loaded polymeric nanomaterials as a novel therapeutic strategy for Alzheimer's disease: A comprehensive review	31
Sestrin2 and mitochondrial quality control: Potential impact in myogenic differentiation	31
Unveiling the role of astrocytes in postoperative cognitive dysfunction	31
AGEING RESEARCH REVIEWS (ARR-D-24-01334R1) Metabolic dysfunction contributes to mood disorders after traumatic brain injury	31
Triaging between post-translational modification of cell cycle regulators and their therapeutics in neurodegenerative diseases	30
Age-related changes in muscle architecture and metabolism in humans: The likely contribution of physical inactivity to age-related functional decline	30
Bridging neurotrophic factors and bioactive peptides to Alzheimer's disease	30
Characterization of the logopenic variant of Primary Progressive Aphasia: A systematic review and meta-analysis	30
New insights into the interplay between miRNAs and autophagy in the aging of intervertebral discs	30
Epigenetic enzymes: A role in aging and prospects for pharmacological targeting	30
A comprehensive review of protein misfolding disorders, underlying mechanism, clinical diagnosis, and therapeutic strategies	30
ChatGPT's dance with neuropsychological data: A case study in Alzheimer’s disease	30
Effects of influenza vaccination on clinical outcomes of chronic obstructive pulmonary disease: A systematic review and meta-analysis	30
Risk factors for falls in older people with cognitive impairment living in the community: Systematic review and meta-analysis	30
Role of the DNAJ/HSP40 family in the pathogenesis of insulin resistance and type 2 diabetes	30
The role of the PLA2G6 gene in neurodegenerative diseases	29
Melatonin: Potential avenue for treating iron overload disorders	29
Unraveling the complexity of human brain: Structure, function in healthy and disease states	29
Cross-sectional associations of tau protein biomarkers with semantic and episodic memory in older adults without dementia: A systematic review and meta-analysis	29
An integrative machine-learning meta-analysis of high-throughput omics data identifies age-specific hallmarks of Alzheimer’s disease	29
The beneficial effects of mesenchymal stem cells and their exosomes on myocardial infarction and critical considerations for enhancing their efficacy	29
Protein intake and physical function in older adults: A systematic review and meta-analysis	29
Components of effective exergame-based training to improve cognitive functioning in middle-aged to older adults – A systematic review and meta-analysis	29
Revolutionizing Alzheimer's treatment: Harnessing human serum albumin for targeted drug delivery and therapy advancements	28
DNA methylation-based age clocks: From age prediction to age reversion	28
Omics sciences for systems biology in Alzheimer’s disease: State-of-the-art of the evidence	28
Global trends and regional differences in mortality of cardiovascular disease and its impact on longevity, 1980–2021: Age-period-cohort analyses and life expectancy decomposition based on the Global B	28
Alcohol consumption in relation to cognitive dysfunction and dementia: A systematic review and dose-response meta-analysis of comparative longitudinal studies	28
Potential convergence of olfactory dysfunction in Parkinson’s disease and COVID-19: The role of neuroinflammation	28
Diabetes mellitus and hearing loss: A review	28
The role of quality of life data as an endpoint for collecting real-world evidence within geroscience clinical trials	27
A gerophysiology perspective on healthy ageing	27
Potential roles of gut microbiota and microbial metabolites in Parkinson’s disease	27
Identification of altered exosomal microRNAs and mRNAs in Alzheimer's disease	27
The NLRP3 inflammasome in fibrosis and aging: The known unknowns	27
Protein glycosylation and glycoinformatics for novel biomarker discovery in neurodegenerative diseases	27
Modifiable lifestyle factors and cognitive reserve: A systematic review of current evidence	27
Editorial Board	27
Prevention and treatment of inflammatory arthritis with traditional Chinese medicine: Underlying mechanisms based on cell and molecular targets	27
Ageing of the gut microbiome: Potential influences on immune senescence and inflammageing	27
Roles of clock genes in the pathogenesis of Parkinson's disease	27
The pollutome-connectome axis: a putative mechanism to explain pollution effects on neurodegeneration	26
Blood-based biomarkers of cerebral small vessel disease	26
Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseases	26
Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?	26
Ferroptosis: Mechanisms and role in diabetes mellitus and its complications	26
Associations of olfactory function with brain structural and functional outcomes. A systematic review	25
Neuroprotection by agmatine: Possible involvement of the gut microbiome?	25
A systematic review of one-legged balance performance and falls risk in community-dwelling adults	25
The link between metabolic syndrome and Alzheimer disease: A mutual relationship and long rigorous investigation	25
Epithelial-mesenchymal transition in age-associated thymic involution: Mechanisms and therapeutic implications	25
Interventions to prevent and treat delirium: An umbrella review of randomized controlled trials	25
Editorial Board	25
Prevalence and patterns of multimorbidity in China during 2002–2022: A systematic review and meta-analysis	25
Evaluation and targeting of amyloid precursor protein (APP)/amyloid beta (Aβ) axis in amyloidogenic and non-amyloidogenic pathways: A time outside the tunnel	25
Exploring cellular senescence in the musculoskeletal system: Any insights for biomarkers discovery?	25
Editorial Board	25
Ageing Research Reviews Special Issue dedicated to women in aging research	24
Effectiveness and safety of Governor vessel acupuncture therapy for post-stroke cognitive impairment: A meta-analysis of randomized controlled trials	24
Targeting impaired nutrient sensing with repurposed therapeutics to prevent or treat age-related cognitive decline and dementia: A systematic review	24
Positive psychological constructs and cognitive function: A systematic review and meta-analysis	24
Sensory nerve regulation of bone homeostasis: Emerging therapeutic opportunities for bone-related diseases	24
Amyloid-induced neurodegeneration: A comprehensive review through aggregomics perception of proteins in health and pathology	24
Modifiable risk factors of dementia linked to excitation-inhibition imbalance	24
Editorial Board	24
Blood brain barrier dysfunction in healthy aging and dementia: Why, how, what for?	24
Exploring role of natural compounds in molecular alterations associated with brain ageing: A perspective towards nutrition for ageing brain	24
The neuromicrobiology of Parkinson’s disease: A unifying theory	24
Diagnostic performance of digital cognitive tests for the identification of MCI and dementia: A systematic review	23
The emerging roles of tRNAs and tRNA-derived fragments during aging: Lessons from studies on model organisms	23