Ageing Research Reviews

Article	Citations
Start the engine of neuroregeneration: A mechanistic and strategic overview of direct astrocyte-to-neuron reprogramming	352
Editorial Board	327
Editorial Board	320
Roles of hypoxia-inducible factor-prolyl hydroxylases in aging and disease	316
cGAS-STING-driven inflammaging cascade in aging-related retinal diseases: From pathological mechanism to therapeutic potentials	299
Type 2 diabetes mellitus augments Parkinson’s disease risk or the other way around: Facts, challenges and future possibilities	264
Dysfunction of norepinephrine and its metabolites in Alzheimer's dementia – A review with meta-analysis	241
Discovery of a new hereditary RECQ helicase disorder RECON syndrome positions the replication stress response and genome homeostasis as centrally important processes in aging and age-related disease	220
Editor’s Note to “Biological constraint, evolutionary spandrels and antagonistic pleiotropy”	210
Reevaluating principal component analysis in geroscience: A call for nonlinear approaches in AI-based evaluations	202
The unique neuropathological vulnerability of the human brain to aging	194
CC chemokines family in fibrosis and aging: From mechanisms to therapy	191
The past, present, and future of adipose tissue browning and aging: A review combined with bibliometrics and bioinformatics of 2527 documents published over the past four decades	186
Guardians of homeostasis: Natural products target metabolic reprogramming in Alzheimer’s disease	182
Intrinsic capacity evolution during aging in mouse and fish: Longitudinal perspectives from a narrative review	179
Targeting tau-mitochondrial crosstalk in Alzheimer’s disease with an Integrative multi-omics and artificial intelligence driven tools for the development of disease-modifying therapeutics	178
Thioredoxin-1 inhibits the activation of IRE1 by targeting Hsp90/p-Cdc37 chaperone complex in Parkinson disease	177
Medication reviews in hospitalised patients for reduced hospital readmission and mortality. Systematic review, meta-analysis and meta-regression of RCTs	172
Histopathological and ultrastructural changes in different cell types during ischemic and hemorrhagic stroke	164
Effectiveness of virtual reality interventions on quality of life, cognitive function and physical function in older people with Alzheimer's disease: A systematic review	161
Unravelling the brain resilience following stroke: From injury to rewiring of the brain through pathway activation, drug targets, and therapeutic interventions	157
Ergothioneine and exercise: A match made in (cognitive) heaven?	151
HIV infection is associated with accelerated epigenetic ageing: A systematic review	148
Unraveling the protein post-translational modification landscape: Neuroinflammation and neuronal death after stroke	145
Sarcobesity: New paradigms for healthy aging related to taurine supplementation, gut microbiota and exercise	145

Cerebral glymphatic system: Structure, regulation, ageing, and mechanisms of encephalopathy	145
Can dementia risk be reduced by following the American Heart Association's Life's Simple 7? A systematic review and dose-response meta-analysis	144
From ageing clocks to organ networks: Biological age-driven organ asynchrony and inter-organ interactions shaping mortality risk	140
Efficacy of technology-based cognitive and exercise interventions for mild cognitive impairment: A systematic review, network meta-analysis, and meta-regression of randomized controlled trials	138
The m⁶A epitranscriptome: A regulatory nexus linking cellular senescence and oncogenesis	138
Microglia and gut microbiota: A double-edged sword in Alzheimer's disease	136
Adenosine metabolism and receptors in aging of the skin, musculoskeletal, immune and cardiovascular systems	135
Repetitive transcranial magnetic stimulation combined with cognitive training for cognitive function and activities of daily living in patients with post-stroke cognitive impairment: A systematic revi	134
Does drug repurposing bridge the gaps in management of Parkinson’s disease? Unravelling the facts and fallacies	133
Glymphatic dysfunction in Parkinson's disease: Aging-associated impairments, imaging biomarkers, and therapeutic strategies	130
Advances in Alzheimer's therapy: Exploring neuropathological mechanisms to revolutionize the future therapeutic landscape	128
Organelle interactome disruption: The systemic pathological mechanisms and therapeutic prospects of mitochondria-lysosome-ER crosstalk in Alzheimer's disease	122
Advances in clinical application of lipidomics in healthy ageing and healthy longevity medicine	121
Prevalence and health outcomes of polypharmacy and hyperpolypharmacy in older adults with frailty: A systematic review and meta-analysis	120
The functions of IRE1α in neurodegenerative diseases: Beyond ER stress	120
Vascular cognitive impairment – Past, present, and future challenges	119
Multifaceted cell death in atherosclerosis: Mechanisms, pathological impact, and therapeutic targeting	118
Global, regional, and national burden of spinal cord injury from 1990 to 2021 and projections for 2050: A systematic analysis for the Global Burden of Disease 2021 study	118
Protein and peptide based nanotherapeutics for the management of Alzheimer’s disease: Current insights and future directions	117
Insulin resistance as a mediator of physical activity's effects on beta-amyloid accumulation and tau phosphorylation: A scoping review	117
Biomarkers associated with cognitive impairment in post-traumatic stress disorder: A systematic review of current evidence	116
The several ways to authentically cure Alzheimer’s dementia	115
Identification of exosomal biomarkers and its optimal isolation and detection method for the diagnosis of Parkinson's disease: A systematic review and meta-analysis	115
The link between metabolic syndrome and Alzheimer disease: A mutual relationship and long rigorous investigation	109
Triaging between post-translational modification of cell cycle regulators and their therapeutics in neurodegenerative diseases	107
Characterization of the logopenic variant of Primary Progressive Aphasia: A systematic review and meta-analysis	106
Unravelling the miscellaneous effects of exercise interventions on activities of daily living in frail older adults: A systematic review and meta-analysis	105
Three-dimensional human brain organoids: A next-generation model to decode Alzheimer’s disease	105
HMGB1, an evolving pleiotropic protein critical for cellular and tissue homeostasis: Role in aging and age-related diseases	103
Associations of olfactory function with brain structural and functional outcomes. A systematic review	103
Quality and recommendations of guidelines for multimorbidity and polypharmacy in older adults: A systematic review	101
Sensory nerve regulation of bone homeostasis: Emerging therapeutic opportunities for bone-related diseases	101
Exercise and the hallmarks of cardiovascular aging	101
Research progress in Alzheimer's disease and bone-brain axis	101
Mitochondria-associated endoplasmic reticulum membranes as aging-sensitive signaling hubs in degenerative musculoskeletal diseases	100
Cytosolic DNA sensor IFI16 proteins: Potential molecular integrators of interactions among the aging hallmarks	97
Transcranial direct current stimulation combined with motor training for motor symptoms in Parkinson's disease: A systematic review and meta-analysis	97
Overview of pro-inflammatory and pro-survival components in neuroinflammatory signalling and neurodegeneration	97
The role of the gut microbiota in neuropsychiatric disorders and therapy	95
Interventions to prevent and treat delirium: An umbrella review of randomized controlled trials	93
Adherence to the Mediterranean diet and risk of frailty and pre-frailty in elderly adults: A systematic review and dose-response meta-analysis with GRADE assessment	93
Trained immunity in the treatment for haematological malignancy	92
Cognitive resilience in Alzheimer’s disease: Mechanism and potential clinical intervention	92
Melatonin: Potential avenue for treating iron overload disorders	91
Neuroprotection by agmatine: Possible involvement of the gut microbiome?	91
Involvement of regulated cell deaths in aging and age-related pathologies	91
The role of the PLA2G6 gene in neurodegenerative diseases	89
Artificial intelligence for fall detection in older adults: A comprehensive survey of machine learning, deep learning approaches, and future directions	88
The effectiveness of dance movement interventions for older adults with mild cognitive impairment, Alzheimer’s disease, and dementia: A systematic scoping review and meta-analysis	88
On the wake of metformin: Do anti-diabetic SGLT2 inhibitors exert anti-aging effects?	87

Blood-based biomarkers for Alzheimer's disease: Advances in early detection and monitoring of age-related neurodegeneration	85
New era of artificial intelligence and machine learning-based detection, diagnosis, and therapeutics in Parkinson’s disease	85
Betaine and aging: A narrative review of findings, possible mechanisms, research perspectives, and practical recommendations	85
Advances of artificial intelligence in predicting frailty using real-world data: A scoping review	84
Targeting aging with urolithin A in humans: A systematic review	84
A Multimodal Meta-Analytical Evidence of Functional and Structural Brain Abnormalities Across Alzheimer's Disease Spectrum	80
Hallmarks of aging: A user’s guide for comparative biologists	80
The mitochondrial integrated stress response: A novel approach to anti-aging and pro-longevity	80
Bridging neurotrophic factors and bioactive peptides to Alzheimer's disease	80
Potential convergence of olfactory dysfunction in Parkinson’s disease and COVID-19: The role of neuroinflammation	78
Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseases	78
Intracellular effects of lithium in aging neurons	78
Role of diet and exercise in aging, Alzheimer’s disease, and other chronic diseases	78
The future of stem cell therapies of Alzheimer’s disease	77
ADP-ribosylation, a multifaceted modification: Functions and mechanisms in aging and aging-related diseases	77
The “cell death interactome” in chronic heart failure: Mechanisms of crosstalk between programmed cell death pathways	77
The plasticity of fibroblasts: A forgotten player in the aging process	77
Immunotherapy for senescent cell clearance: Hallmarks, strategies and translational challenges	77
The role of in silico and in vitro models in Parkinson’s disease: Drug discovery and therapy applications	76
Molecular hydrogen therapy: A “democratic” emerging strategy against aging and age-related diseases	76
A novel regulator in Alzheimer's disease progression: The astrocyte-derived extracellular vesicles	76
From lifespan extension to hallmark-informed gerotherapeutic prioritization: A bibliometric-guided, strategy-oriented review of anti-aging drug research	75
The evidence for epigenetic age acceleration in neurological disease: A systematic review	75
Targeting HDAC6 and its novel E3 ligase activity: A dual-strategy for cardiovascular therapy	75
Under the umbrella of depression and Alzheimer’s disease physiopathology: Can cannabinoids be a dual-pleiotropic therapy?	75
Molecular and environmental drivers of tau post-translational modifications and tau pathology	75
Fanconi anaemia as a human model of accelerated epigenetic and immune ageing	74
Advances in eye-brain axis: Anatomy, immunity, and association with visual dysfunction	74
Frailty and the brain: A narrative review of functional and pathological correlates	73
Expanding evolutionary theories of ageing to better account for symbioses and interactions throughout the Web of Life	73
A critical appraisal of blood-based biomarkers for Alzheimer’s disease	73
Healthy brain aging and delayed dementia in Texas rural elderly	72
Turquoise killifish: A natural model of age-dependent brain degeneration	72
HADHA in cardiovascular disease: From mitochondrial dysfunction to therapeutic targets	72
Unravelling of molecular biomarkers in synaptic plasticity of Alzheimer’s disease: Critical role of the restoration of neuronal circuits	71
Regulated cell death in acute myocardial infarction: Molecular mechanisms and therapeutic implications	71
Serotonin-mediated regulation of mitophagy in Alzheimer's disease: Mechanistic insights and therapeutic potential	71
The role of exercise in the prevention and treatment of Alzheimer’s disease and mild cognitive impairments	71
Latest developments of microphysiological systems (MPS) in aging-related and geriatric diseases research: A review	70
The cross-talk between the cGAS-STING signaling pathway and chronic inflammation in the development of musculoskeletal disorders	70
Modifiable risk factors for mild cognitive impairment among cognitively normal community-dwelling older adults: A systematic review and meta-analysis	70
Association between pulse wave velocity and white matter hyperintensities among older adults: A meta-analysis of cross-sectional and longitudinal studies	70
The effect of ferroptosis-related mitochondrial dysfunction in the development of temporal lobe epilepsy	70
Association of frailty and pre-frailty with all-cause and cardiovascular mortality in diabetes: Three prospective cohorts and a meta-analysis	69
Beyond the Hayflick limit: How microbes influence cellular aging	69
Aryl hydrocarbon receptor: From pathogenesis to therapeutic targets in aging-related tissue fibrosis	69
Long-term human spaceflight and inflammaging: Does it promote aging?	69
Drug repositioning for Parkinson’s disease: An emphasis on artificial intelligence approaches	69
cGAS-STING targeting offers novel therapeutic opportunities in neurological diseases	69
Role of Nrf2 in aging, Alzheimer’s and other neurodegenerative diseases	69
Suicide and dementia: A systematic review and meta-analysis of prevalence and risk factors	69
Computerized cognitive training in Parkinson’s disease: A systematic review and meta-analysis	69
Modulators of ASIC1a and its potential as a therapeutic target for age-related diseases	69
Biological constraint, evolutionary spandrels and antagonistic pleiotropy	68
Targeting the gut microbiota-related metabolites for osteoporosis: The inextricable connection of gut-bone axis	68
Oral health indicators and bone mineral density disorders in older age: A systematic review	68
Small molecule modulators of alpha-synuclein aggregation and toxicity: Pioneering an emerging arsenal against Parkinson’s disease	67
Is COVID-19 really a geriatric syndrome?	67
A review on neurodegeneration in the fast-ageing killifish, the first animal model to study the natural occurrence of neuronal cell loss	67
Decoding synaptic imbalance in neurodegenerative diseases: From pathological analysis to targeted intervention	66
Unlocking the potential of histone deacetylase inhibitors in combatting age-related retinal degenerative diseases	66
BACE1-dependent metabolism of neuregulin 1: Bridging the gap in explaining the occurrence of schizophrenia-like symptoms in Alzheimer's disease with psychosis?	66
Consolidating multiple evolutionary theories of ageing suggests a need for new approaches to study genetic contributions to ageing decline	66
From onset to advancement: the temporal spectrum of α-synuclein in synucleinopathies	66
Underserved groups in dysphagia intervention trials in Parkinson’s disease: A scoping review	66
Brain drug delivery and neurodegenerative diseases: Polymeric PLGA-based nanoparticles as a forefront platform	65
Restoration of epigenetic impairment in the skeletal muscle and chronic inflammation resolution as a therapeutic approach in sarcopenia	65
Association between lipocalin-2 and mild cognitive impairment or dementia: A systematic review and meta-analysis of population-based evidence	65
Evaluating senescence-targeted approaches in Alzheimer’s Disease: What we know and what lies ahead	65
Mortality prediction models for community-dwelling older adults: A systematic review	65
Hormesis defines the limits of lifespan	65
Alzheimer's disease and Alzheimer’s disease-related dementias in Hispanics: Identifying influential factors and supporting caregivers	64
Resolution of inflammation, an active process to restore the immune microenvironment balance: A novel drug target for treating arterial hypertension	64
Aryl hydrocarbon receptor (AhR) impairs circadian regulation: Impact on the aging process	64
Cellular senescence in ischemic stroke: Cell-type specificity, temporal dynamics, and response to therapeutic interventions	64
The mechanism of cuproptosis in Parkinson’s disease	63
Recent advancement in understanding of Alzheimer's disease: Risk factors, subtypes, and drug targets and potential therapeutics	63
The metabolic and endocrine impact of diet-derived gut microbiota metabolites on ageing and longevity	62
Biomarkers of female reproductive aging in gerotherapeutic clinical trials	62
Antioxidants in anti‐Alzheimer's disease drug discovery	61

Telomere length and brain aging: A systematic review and meta-analysis	61
NAD⁺ supplementation for anti-aging and wellness: A PRISMA-guided systematic review of preclinical and clinical evidence	61
The mechanisms of mitochondrial abnormalities that contribute to sleep disorders and related neurodegenerative diseases	61
Gating of Somatosensory Neural Oscillations Across the Lifespan: A Narrative Review	60
The memory- and cognition-facilitating effects of spermidine in aging and aging-related disorders	60
Neurobiology of depression in Parkinson’s disease: Insights into epidemiology, molecular mechanisms and treatment strategies	60
Global burden, risk factors, and projections of early-onset dementia: Insights from the Global Burden of Disease Study 2021	59
Transposable elements and their role in aging	58
Editorial Board	58
Ageing and liver immune cells	57
Modulating α-synuclein propagation and decomposition: Implications in Parkinson's disease therapy	57
Single-cell sequencing insights into the transcriptional landscape of Parkinson's disease	57
FAM19A5 in vascular aging and osteoporosis: Mechanisms and the “calcification paradox”	57
Lactylation: Unlocking the regulatory code of exercise-mediated anti-aging	56
Prevalence of psychotic symptoms in mild cognitive impairment: A systematic review and meta-analysis	56
Cerebellar pathology in forensic and clinical neuroscience	55
The STAT3 paradox in aging: Molecular mechanisms and targeted therapeutic strategies	55
Building an ontology of resilience: Insights from the physical resilience literature	55
The role of DEAD-box helicases in cardiovascular diseases	55
Advances in modeling memory decline: A critical overview of current animal and human paradigms	55
Impact of exercise intervention-based changes on physical function biomarkers in older adults after hospital discharge: A systematic review with meta-analysis of randomized clinical trials	54
Understanding age-related pathologic changes in TDP-43 functions and the consequence on RNA splicing and signalling in health and disease	54
Next-generation biosensor technologies for Alzheimer’s disease: Innovations in diagnosis, monitoring, and treatment	54
Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease	54
Effect of ketogenic diets on insulin-like growth factor (IGF)-1 in humans: A systematic review and meta-analysis	54
Fractal dimension of the brain in neurodegenerative disease and dementia: A systematic review	54
Long-term fasting and its influence on inflammatory biomarkers: A comprehensive scoping review	54
Associations between vision impairment and eye diseases with dementia, dementia subtypes and cognitive impairment: An umbrella review	53
The mitochondria-synapse axis in Alzheimer’s disease: Lost coordination in early stages	53
Cerebral small vessel disease pathology in COVID-19 patients: A systematic review	53
Epidemiological trends and cross-country inequalities in the global burden of Alzheimer's disease and other dementias in postmenopausal women from 1990 to 2021	53
Sirtuins in Parkinson's disease: Molecular mechanisms and pathophysiological roles	53
Exploring Parkinson-associated kinases for CRISPR/Cas9-based gene editing: beyond alpha-synuclein	52
Efficacy of rehabilitation robot-assisted gait training on lower extremity dyskinesia in patients with Parkinson's disease: A systematic review and meta-analysis	52
Epigenetic biomarkers in Alzheimer's disease: Diagnostic and prognostic relevance	52
Multi-omics strategies to decode the molecular landscape of cellular senescence	52
Mitochondrial transfer between cell crosstalk – An emerging role in mitochondrial quality control	52
The impact of ageing on faecal short chain fatty acids levels in apparently healthy adults: A systematic review and meta-analysis	51
Heat stroke: Pathogenesis, diagnosis, and current treatment	51
The senotherapeutic potential of phytochemicals for age-related intestinal disease	51
Biological resilience and aging: Activation of stress response pathways contributes to lifespan extension	51
Impact of frailty on all-cause mortality or major amputation in patients with lower extremity peripheral artery disease: A meta-analysis	50
Blood pressure variability: A potential marker of aging	50
MSC-EVs alleviate osteoarthritis by regulating microenvironmental cells in the articular cavity and maintaining cartilage matrix homeostasis	50
Liver X receptors and the hallmarks of aging: From molecular mechanisms to therapeutic opportunities	50
RNA binding proteins in senescence: A potential common linker for age-related diseases?	50
Osteosarcopenic adiposity (OSA) phenotype and its connection with cardiometabolic disorders: Is there a cause-and-effect?	49
A cross-talk between sestrins, chronic inflammation and cellular senescence governs the development of age-associated sarcopenia and obesity	49
Editorial Board	49
Editorial Board	49
Nanotechnology-based advancements in Parkinson's therapy: Exploring animal models and clinical insights in neurodegenerative disorders	49
Markers of biological age in dogs	49
Adipose tissue and ovarian aging: Potential mechanism and protective strategies	48
Updates on brain regions and neuronal circuits of movement disorders in Parkinson’s disease	48
Nuclear receptors in age-related diseases: From mechanisms to drug discovery	48
Research progress on carotid artery changes and cognitive impairment in Alzheimer's disease patients	48
Targeting impaired nutrient sensing via the sirtuin pathway with novel compounds to prevent or treat dementia: A systematic review	47
Tiny Titans, big promise: Nanotechnology and microRNA in the fight against Alzheimer’s disease	47
Towards a comprehensive framework for complex walking tasks: Characterization, behavioral adaptations, and clinical implications in ageing and neurological populations	47
Prevalence of alcohol use among U.S. older adults with pain: A scoping review	47
Resolving the current controversy of use and reuse of housekeeping proteins in ageing research: Focus on saving people’s tax dollars	46
Dementia, osteoporosis and fragility fractures: Intricate epidemiological relationships, plausible biological connections, and twisted clinical practices	46
Is cognitive reserve associated with the prevention of cognitive decline after stroke? A Systematic review and meta-analysis	46
Neurobiological role and therapeutic potential of exercise-induced irisin in Alzheimer's disease management	46
Multi-omics research strategies in ischemic stroke: A multidimensional perspective	46
The prognostic impacts of frailty on clinical and patient-reported outcomes in patients undergoing coronary artery or valvular surgeries/procedures: A systematic review and meta-analysis	46
Cannabidiol and neurodegeneration: From molecular mechanisms to clinical benefits	45
Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central nervous system	45
The role of oxidative stress in intervertebral disc degeneration: Mechanisms and therapeutic implications	45
The interplay of NAD and hypoxic stress and its relevance for ageing	45
Osteoporosis and Alzheimer´s disease (or Alzheimer´s disease and Osteoporosis)	45
Deciphering the mechanistic impact of acupuncture on the neurovascular unit in acute ischemic stroke: Insights from basic research in a narrative review	45
The conceivable role of prolactin hormone in Parkinson disease: The same goal but with different ways	45
Effects of exercise interventions on cognitive functions in healthy populations: A systematic review and meta-analysis	45
Emerging therapeutics agents and recent advances in drug repurposing for Alzheimer’s disease	44
Harnessing two-dimensional nanomaterials for diagnosis and therapy in neurodegenerative diseases: Advances, challenges and prospects	44
Editorial Board	44
Is it time to revise the fighting strategy toward type 2 diabetes? Sex and pollution as new risk factors	44
Editorial Board	44
Epigenetic clock: A promising biomarker and practical tool in aging	44
Modeling aging in a culture dish: towards the development of more sophisticated in vitro models of human skin aging	44
Mendelian randomization analyses reveal relationships between white matter microstructure and risk of abdominal aortic aneurysm	44
Interlinked role of ASN, TDP-43 and Miro1 with parkinopathy: Focus on targeted approach against neuropathy in parkinsonism	43
Reelin links Apolipoprotein E4, Tau, and Amyloid‐β in Alzheimer’s disease	43
Testicular aging revisited: Current understanding of mechanisms and emerging interventions	43
RETRACTED: Prevention of cardiovascular disease for healthy aging and longevity: A new scoring system and related “mechanisms-hallmarks-biomarkers”	43
Exerkines: Potential regulators of diabetic cardiomyopathy	43
Exploring cytokines dynamics: Uncovering therapeutic concepts for metabolic disorders in postmenopausal women- diabetes, metabolic bone diseases, and non-alcohol fatty liver disease	43
Immunometabolism and immune response regulate macrophage function in atherosclerosis	43
Reducing Alzheimer’s disease risk with SGLT2 inhibitors: From glycemic control to neuroprotection	43
The ethics case for longevity science	43
Motoric cognitive risk syndrome as a predictive factor of cognitive impairment and dementia – A systematic review and meta-analysis	43
Definitions of healthspan: A systematic review	43
The social microbiome of older people	42
The Hallmarks of aging: Paradigms and scientific progress	42