Ageing Research Reviews

Article	Citations
Evolving landscape of colorectal cancer: Global and regional burden, risk factor dynamics, and future scenarios (the Global Burden of Disease 1990–2050)	363
Quercetin-functionalized nanomaterials: Innovative therapeutic avenues for Alzheimer's disease management	323
Comparison between frail and non-frail older adults’ gut microbiota: A systematic review and meta-analysis	300
Prevalence of radicular neuropathic pain in idiopathic Parkinson’s disease: A systematic review and meta-analysis	263
Research progress in the molecular mechanism of ferroptosis in Parkinson's disease and regulation by natural plant products	229
Passive Alzheimer’s immunotherapy: A promising or uncertain option?	187
Advances in clinical application of lipidomics in healthy ageing and healthy longevity medicine	181
Tau internalization: A complex step in tau propagation	170
Type 2 diabetes mellitus augments Parkinson’s disease risk or the other way around: Facts, challenges and future possibilities	169
Bridging geriatric medicine, clinical pharmacology and ageing biology to understand and improve outcomes of medicines in old age and frailty	169
DNA methylation in genes associated with the evolution of ageing and disease: A critical review	168
Restoring the oxidative balance in age-related diseases – An approach in glaucoma	165
Discovery of a new hereditary RECQ helicase disorder RECON syndrome positions the replication stress response and genome homeostasis as centrally important processes in aging and age-related disease	159
Editorial Board	151
Editorial Board	148
Effects of tart cherry and its metabolites on aging and inflammatory conditions: Efficacy and possible mechanisms	144
Dysfunction of norepinephrine and its metabolites in Alzheimer's dementia – A review with meta-analysis	140
Interlinked role of ASN, TDP-43 and Miro1 with parkinopathy: Focus on targeted approach against neuropathy in parkinsonism	134
Psychometric characteristics of comprehensive geriatric assessments (CGAs) for long-term care facilities and community care: A systematic review	123
Editorial Board	119
Balance-based exercise programs on balance in older adults with mild to moderate dementia: A critically appraised topic	118
Editorial Board	113
Pyroptosis: Mechanisms and links with diabetic cardiomyopathy	110
Universal masking during COVID-19 outbreaks in aged care settings: A systematic review and meta-analysis	109
Harnessing two-dimensional nanomaterials for diagnosis and therapy in neurodegenerative diseases: Advances, challenges and prospects	109

Editorial Board	108
Association of F2-isoprostane levels with Alzheimer’s disease in observational studies: A systematic review and meta-analysis	107
Editorial Board	106
Editorial Board	101
Reply to “Caution in underrepresentation of older adults in clinical trials on COVID-19 vaccines”	100
The oral organ: A new vision of the mouth as a whole for a gerophysiological approach to healthy aging	99
Transcranial magnetic stimulation (TMS) for geriatric depression	97
Modulation of cholesterol metabolism with Phytoremedies in Alzheimer’s disease: A comprehensive review	95
Interspecific interactions that affect ageing: Age-distorters manipulate host ageing to their own evolutionary benefits	92
Determining the cortical, spinal and muscular adaptations to strength-training in older adults: A systematic review and meta-analysis	91
COVID-19 mortality as a fingerprint of biological age	90
Reelin links Apolipoprotein E4, Tau, and Amyloid‐β in Alzheimer’s disease	89
Pharmaceutical and nutraceutical activation of FOXO3 for healthy longevity	88
Caenorhabditis elegans: A transgenic model for studying age-associated neurodegenerative diseases	88
Modulating the polarization phenotype of microglia – A valuable strategy for central nervous system diseases	87
The protein inputs of an ultra-predictive aging clock represent viable anti-aging drug targets	87
Neolignans in Magnolia officinalis as natural anti-Alzheimer’s disease agents: A systematic review	86
Constituent isoflavones of Puerariae radix as a potential neuroprotector in cognitive impairment: Evidence from preclinical studies	83
Is it time to revise the fighting strategy toward type 2 diabetes? Sex and pollution as new risk factors	83
Immunometabolism and immune response regulate macrophage function in atherosclerosis	82
Determinants of approved acetylcholinesterase inhibitor response outcomes in Alzheimer’s disease: relevance for precision medicine in neurodegenerative diseases	79
Developing transcriptomic signatures as a biomarker of cellular senescence	79
Can extracellular vesicles be considered as a potential frontier in the treatment of intervertebral disc disease?	78
Unraveling the protein post-translational modification landscape: Neuroinflammation and neuronal death after stroke	77
Neuroenergetic alterations in neurodegenerative diseases: A systematic review and meta-analysis of in vivo 31P-MRS studies	76
The emerging role of exercise in Alzheimer’s disease: Focus on mitochondrial function	76
Sarcobesity: New paradigms for healthy aging related to taurine supplementation, gut microbiota and exercise	76
Sex difference, proteostasis and mitochondrial function impact stroke-related sarcopenia—A systematic review and meta-analysis	75
Target modulation of glycolytic pathways as a new strategy for the treatment of neuroinflammatory diseases	74
Motoric cognitive risk syndrome as a predictive factor of cognitive impairment and dementia – A systematic review and meta-analysis	73
Exploring cytokines dynamics: Uncovering therapeutic concepts for metabolic disorders in postmenopausal women- diabetes, metabolic bone diseases, and non-alcohol fatty liver disease	72
Obesity-induced neuronal senescence: Unraveling the pathophysiological links	72
Pangenomics: A new era in the field of neurodegenerative diseases	70
Risk factors for multimorbidity in adulthood: A systematic review	68
Lifestyle strategies to promote proteostasis and reduce the risk of Alzheimer’s disease and other proteinopathies	68
Pasteurized non-fermented cow’s milk but not fermented milk is a promoter of mTORC1-driven aging and increased mortality	67
Prediction models for depression risk among older adults: systematic review and critical appraisal	67
A review of dementia, focusing on the distinct roles of viral protein corona and MMP9 in dementia: Potential pharmacotherapeutic priorities	66
Sarcopenia defined by the psoas muscle mass or quality is associated with poor survival in patients with aortic aneurysm undergoing surgery: A meta-analysis	66
Apathy in Alzheimer’s disease: A neurocircuitry based perspective	64
Machine learning in Alzheimer’s disease drug discovery and target identification	64
Recent advances in the field of caloric restriction mimetics and anti-aging molecules	63
Genetic aberration analysis of mitochondrial respiratory complex I implications in the development of neurological disorders and their clinical significance	63
The association of living alone and social isolation with sarcopenia: A systematic review and meta-analysis	63
Systematic analysis of nutrigenomic effects of polyphenols related to cardiometabolic health in humans – Evidence from untargeted mRNA and miRNA studies	62
The functions of IRE1α in neurodegenerative diseases: Beyond ER stress	61
Senescence in tissue samples of humans with age-related diseases: A systematic review	60
From biological aging to functional decline: Insights into chronic inflammation and intrinsic capacity	60
Precision neurology	58
Lactylation modification in cardio-cerebral diseases: A state-of-the-art review	58

Inflammatory signaling pathways in Alzheimer's disease: Mechanistic insights and possible therapeutic interventions	58
Sarcopenia in trauma patients: A systematic review and meta-analysis	58
Updated systematic review and meta-analysis on diagnostic issues and the prognostic impact of myosteatosis: A new paradigm beyond sarcopenia	57
Combined physical and cognitive training for older adults with and without cognitive impairment: A systematic review and network meta-analysis of randomized controlled trials	56
Bio-enhanced fraction from Clitoria ternatea root extract ameliorates cognitive functions and in vivo hippocampal neuroplasticity in chronic cerebral hypoperfusion rat model	54
Types of exercise and training duration on depressive symptoms among older adults in long-term care facilities	54
Therapeutic potential of lipid nanosystems for the treatment of Parkinson’s disease	54
Stepping impairment and falls in older adults: A systematic review and meta-analysis of volitional and reactive step tests	54
Macrophage membrane-camouflaged biomimetic nanovesicles for targeted treatment of arthritis	54
Frailty in rodents: Models, underlying mechanisms, and management	54
Beyond cardiovascular risk: Implications of Familial hypercholesterolemia on cognition and brain function	54
The retina: A window in which to view the pathogenesis of Alzheimer’s disease	53
Prevalence and health outcomes of polypharmacy and hyperpolypharmacy in older adults with frailty: A systematic review and meta-analysis	53
Risk of seizures and subclinical epileptiform activity in patients with dementia: A systematic review and meta-analysis	53
The emerging role of exosomes in Alzheimer’s disease	52
Emerging therapeutics agents and recent advances in drug repurposing for Alzheimer’s disease	52
Advancements in computer-assisted diagnosis of Alzheimer's disease: A comprehensive survey of neuroimaging methods and AI techniques for early detection	51
Autophagy in aging-related diseases and cancer: Principles, regulatory mechanisms and therapeutic potential	51
Immunity orchestrates a bridge in gut-brain axis of neurodegenerative diseases	51
Mesencephalic astrocyte-derived neurotrophic factor (MANF): Structure, functions and therapeutic potential	50
Exploring the conceptual framework and measurement model of intrinsic capacity defined by the World Health Organization: A scoping review	50
Mechanism and therapeutic targets of the involvement of a novel lysosomal proton channel TMEM175 in Parkinson's disease	49
Advancing the understanding of diabetic encephalopathy through unravelling pathogenesis and exploring future treatment perspectives	49
Does personality affect the cognitive decline in aging? A systematic review	49
Can dementia risk be reduced by following the American Heart Association's Life's Simple 7? A systematic review and dose-response meta-analysis	49
Efficacy of technology-based cognitive and exercise interventions for mild cognitive impairment: A systematic review, network meta-analysis, and meta-regression of randomized controlled trials	49
The unique neuropathological vulnerability of the human brain to aging	48
Effects of interventions on cerebral perfusion in the Alzheimer's disease spectrum: A systematic review	47
The underlying roles and neurobiological mechanisms of music-based intervention in Alzheimer's disease: A comprehensive review	47
Multiomics insights into the female reproductive aging	46
Potential mechanisms underlying the accelerated cognitive decline in people with chronic low back pain: A scoping review	46
Improving geriatric outcomes through nutritional and immunonutritional strategies: Focus on surgical setting by a comprehensive evidence review	45
MicroRNAs in the regulation of autophagy and their possible use in age-related macular degeneration therapy	45
CC chemokines family in fibrosis and aging: From mechanisms to therapy	45
A new face of old cells: An overview about the role of senescence and telomeres in inflammatory bowel diseases	44
Spatial omics: An innovative frontier in aging research	44
p62 works as a hub modulation in the ageing process	44
Sirtuins, resveratrol and the intertwining cellular pathways connecting them	44
Role of enteric glia and microbiota-gut-brain axis in parkinson disease pathogenesis	44
The accelerated aging phenotype: The role of race and social determinants of health on aging	43
How good is the evidence that cellular senescence causes skin ageing?	43
Role of UCHL1 in the pathogenesis of neurodegenerative diseases and brain injury	43
Targeted microbiota dysbiosis repair: An important approach to health management after spinal cord injury	42
Short-chain fatty acid metabolism and multiple effects on cardiovascular diseases	42
Vascular dementia: A microglia's perspective	42
Unveiling the role of astrocytes in postoperative cognitive dysfunction	42
Passive immunotherapy for Alzheimer's disease	41
Associations between social health factors, cognitive activity and neurostructural markers for brain health – A systematic literature review and meta-analysis	41
Past, present and future of therapeutic strategies against amyloid-β peptides in Alzheimer’s disease: a systematic review	41
Mitochondrial dysfunction in aging	41
Biomarkers used in Alzheimer’s disease diagnosis, treatment, and prevention	41
Vascular cognitive impairment – Past, present, and future challenges	41
Gut microbiome and Alzheimer’s disease: What we know and what remains to be explored	40
Curcumin-loaded polymeric nanomaterials as a novel therapeutic strategy for Alzheimer's disease: A comprehensive review	40
Innovative approaches to Alzheimer's therapy: Harnessing the power of heterocycles, oxidative stress management, and nanomaterial drug delivery system	40
Microglia and gut microbiota: A double-edged sword in Alzheimer's disease	40
Novel fluid biomarkers for mild cognitive impairment: A systematic review and meta-analysis	40
Development of nanomedicines for the treatment of Alzheimer’s disease: Raison d’être, strategies, challenges and regulatory aspects	39
Repetitive transcranial magnetic stimulation combined with cognitive training for cognitive function and activities of daily living in patients with post-stroke cognitive impairment: A systematic revi	39
Curcumin nanoformulations to combat aging-related diseases	39
Rethinking IRPs/IRE system in neurodegenerative disorders: Looking beyond iron metabolism	39
Thioredoxin-1 inhibits the activation of IRE1 by targeting Hsp90/p-Cdc37 chaperone complex in Parkinson disease	39
Artificial intelligence in brain MRI analysis of Alzheimer’s disease over the past 12 years: A systematic review	38
Redox imbalance in age-related ovarian dysfunction and perspectives for its prevention	38
CXCL12/CXCR4: An amazing challenge and opportunity in the fight against fibrosis	38
Inflammatory pathways in Alzheimer’s disease mediated by gut microbiota	38
Socially assistive robots for people with dementia: Systematic review and meta-analysis of feasibility, acceptability and the effect on cognition, neuropsychiatric symptoms and quality of life	37
Relationship between obesity and structural brain abnormality: Accumulated evidence from observational studies	37
Beta-adrenergic drugs and risk of Parkinson’s disease: A systematic review and meta-analysis	37
Oxidative stress and antioxidant defenses in mild cognitive impairment: A systematic review and meta-analysis	37
Rebalancing the unbalanced aged immune system – A special focus on zinc	37
The roles of the Hippo-YAP signalling pathway in Cartilage and Osteoarthritis	36
Psychedelics for alzheimer's disease-related dementia: Unveiling therapeutic possibilities and pathways	36
Energy metabolism and frailty: The potential role of exercise-induced myokines – A narrative review	36
Frailty and pain, human studies and animal models	35
Evolving therapeutic interventions for the management and treatment of Alzheimer’s disease	35
Stress, diet, exercise: Common environmental factors and their impact on epigenetic age	35
Research progress on the effects of novel hypoglycemic drugs in diabetes combined with myocardial ischemia/reperfusion injury	35
Poly (ADP-ribose) polymerase 1 and neurodegenerative diseases: Past, present, and future	35
Is personality associated with dementia risk? A meta-analytic investigation	35

Fungi as a source of bioactive molecules for the development of longevity medicines	34
Prevalence of multidimensional frailty and pre-frailty in older people in different settings: A systematic review and meta-analysis	34
Principles of brain aging: Status and challenges of modeling human molecular changes in mice	34
Deregulated mitochondrial microRNAs in Alzheimer's disease: Focus on synapse and mitochondria	34
The hallmarks of aging in Ataxia-Telangiectasia	33
Senescent cells as promising targets to tackle age-related diseases	33
Optimal dose and type of exercise to improve cognitive function in older adults: A systematic review and bayesian model-based network meta-analysis of RCTs	33
The functions and regulation of Otubains in protein homeostasis and diseases	33
Hypoxia and hemorheological properties in older individuals	33
To breathe or not to breathe: Understanding how oxygen sensing contributes to age-related phenotypes	33
miR-21 and miR-146a: The microRNAs of inflammaging and age-related diseases	33
Adult-onset hearing loss and incident cognitive impairment and dementia – A systematic review and meta-analysis of cohort studies	32
Sex biology in amyotrophic lateral sclerosis	32
Calprotectin in Parkinsonian disease: Anticipation and dedication	32
The classical and non-classical axes of renin-angiotensin system in Parkinson disease: The bright and dark side of the moon	32
Semaglutide as a possible therapy for healthy aging: Targeting the hallmarks of aging	31
Editorial Board	31
Priorities in tackling noncommunicable diseases among the population aged 60 years and older in China, 1990–2021: A population-based study	31
Progress in the mechanisms of pain associated with neurodegenerative diseases	31
Mitochondria break free: Mitochondria-derived vesicles in aging and associated conditions	31
Ageing, proteostasis, and the gut: Insights into neurological health and disease	30
Exercise-induced adaptive response of different immune organs during ageing	30
Global, regional, and national burden of spinal cord injury from 1990 to 2021 and projections for 2050: A systematic analysis for the Global Burden of Disease 2021 study	30
Regulation of DNA damage response by RNA/DNA-binding proteins: Implications for neurological disorders and aging	30
Roles of hypoxia-inducible factor-prolyl hydroxylases in aging and disease	30
The impact of aging on HIV-1-related neurocognitive impairment	30
Disease-modifying therapies for Alzheimer’s disease: Clinical trial progress and opportunity	30
Breaking new ground on human health and well-being with epigenetic clocks: A systematic review and meta-analysis of epigenetic age acceleration associations	30
Advances in human cellular mechanistic understanding and drug discovery of brain organoids for neurodegenerative diseases	30
Structural and physiological changes of the kidney with age and its impact on chronic conditions and COVID-19	30
Characterization of the logopenic variant of Primary Progressive Aphasia: A systematic review and meta-analysis	29
Exploring advancements in early detection of Alzheimer's disease with molecular assays and animal models	29
Metabolic dysfunction contributes to mood disorders after traumatic brain injury	29
Sestrin2 and mitochondrial quality control: Potential impact in myogenic differentiation	29
The epitranscriptome in ageing and stress resistance: A systematic review	29
Unknown roles of tau pathology in neurological disorders. Challenges and new perspectives	29
Endogenous retroviruses in multiple sclerosis: A network-based etiopathogenic model	29
Medication reviews in hospitalised patients for reduced hospital readmission and mortality. Systematic review, meta-analysis and meta-regression of RCTs	29
Reactive astrocytes: The nexus of pathological and clinical hallmarks of Alzheimer’s disease	28
Biomarkers of aging in frailty and age-associated disorders: State of the art and future perspective	28
Lipocalin 2 as a link between ageing, risk factor conditions and age-related brain diseases	28
Treatment avenues for age-related macular degeneration: Breakthroughs and bottlenecks	28
Circadian regulation of microglia function: Potential targets for treatment of Parkinson’s Disease	28
Fading memories in aging and neurodegeneration: Is p75 neurotrophin receptor a culprit?	28
Cosmic chronometers: Is spaceflight a catalyst for biological ageing?	28
Hypoxia and brain aging: Neurodegeneration or neuroprotection?	27
Novel insights of EZH2-mediated epigenetic modifications in degenerative musculoskeletal diseases	27
Editorial Board	27
Adipose–Muscle crosstalk in age-related metabolic disorders: The emerging roles of adipo-myokines	27
Heart rate variability in relation to cognition and behavior in neurodegenerative diseases: A systematic review and meta-analysis	27
Diagnostic accuracy of blood biomarkers for Alzheimer’s disease and amnestic mild cognitive impairment: A meta-analysis	27
Exercise and gait/movement analyses in treatment and diagnosis of Parkinson’s Disease	27
DNA methylation-based age clocks: From age prediction to age reversion	27
An integrative machine-learning meta-analysis of high-throughput omics data identifies age-specific hallmarks of Alzheimer’s disease	27
Glymphatic pathway in sporadic cerebral small vessel diseases: From bench to bedside	27
Exercise training increases telomerase reverse transcriptase gene expression and telomerase activity: A systematic review and meta-analysis	27
Unraveling the complexity of human brain: Structure, function in healthy and disease states	26
The role of nerve fibers and their neurotransmitters in regulating intervertebral disc degeneration	26
Alcohol consumption in relation to cognitive dysfunction and dementia: A systematic review and dose-response meta-analysis of comparative longitudinal studies	26
The hippocampus associated GABAergic neural network impairment in early-stage of Alzheimer's disease	26
Revolutionizing Alzheimer's treatment: Harnessing human serum albumin for targeted drug delivery and therapy advancements	26
The NLRP3 inflammasome in fibrosis and aging: The known unknowns	25
Neutrophils and neutrophil extracellular trap components: Emerging biomarkers and therapeutic targets for age-related eye diseases	25
Research progress in Alzheimer's disease and bone-brain axis	25
The mitochondrial integrated stress response: A novel approach to anti-aging and pro-longevity	25
Untangle the mystery behind DS-associated AD – Is APP the main protagonist?	25
Focus of endothelial glycocalyx dysfunction in ischemic stroke and Alzheimer’s disease: Possible intervention strategies	25
Physical activity and neurotrophic factors as potential drivers of neuroplasticity in Parkinson’s Disease: A systematic review and meta-analysis	25
Global trends and regional differences in mortality of cardiovascular disease and its impact on longevity, 1980–2021: Age-period-cohort analyses and life expectancy decomposition based on the Global B	25
In vivo imaging of synaptic density in neurodegenerative disorders with positron emission tomography: A systematic review	25
Potential convergence of olfactory dysfunction in Parkinson’s disease and COVID-19: The role of neuroinflammation	25
ChatGPT's dance with neuropsychological data: A case study in Alzheimer’s disease	25
Epigenetic modifications of inflammation in intervertebral disc degeneration	24
Physiological functions of podosomes: From structure and function to therapy implications in osteoclast biology of bone resorption	24
Cross-sectional associations of tau protein biomarkers with semantic and episodic memory in older adults without dementia: A systematic review and meta-analysis	24
Diabetes mellitus and hearing loss: A review	24
Components of effective exergame-based training to improve cognitive functioning in middle-aged to older adults – A systematic review and meta-analysis	24
Interventions to prevent and treat delirium: An umbrella review of randomized controlled trials	24
The protective effect of mindfulness and compassion meditation practices on ageing: Hypotheses, models and experimental implementation	24
The prevalence of frailty and pre-frailty among geriatric hospital inpatients and its association with economic prosperity and healthcare expenditure: A systematic review and meta-analysis of 467,779	24
The emerging roles of tRNAs and tRNA-derived fragments during aging: Lessons from studies on model organisms	24
Effects of digital-based interventions on the outcomes of the eligibility criteria for sarcopenia in healthy older adults: A systematic review and meta-analysis	24
The role of the PLA2G6 gene in neurodegenerative diseases	24
Positive psychological constructs and cognitive function: A systematic review and meta-analysis	23
Ageing Research Reviews Special Issue dedicated to women in aging research	23
Editorial Board	23
Exploring cellular senescence in the musculoskeletal system: Any insights for biomarkers discovery?	23
Editorial Board	23
A systematic review of one-legged balance performance and falls risk in community-dwelling adults	23
Editorial Board	23
Editorial Board	23
Editorial Board	23
Effectiveness of Cognitive Stimulation Therapy (CST) for mild to moderate dementia: A systematic literature review and meta-analysis of randomised control trials using the original CST protocol	22
The neuromicrobiology of Parkinson’s disease: A unifying theory	22
Effects of exercise interventions on executive function in old adults with mild cognitive impairment: A systematic review and meta-analysis of randomized controlled trials	22