Ageing Research Reviews

Article	Citations
Aging in COVID-19: Vulnerability, immunity and intervention	664
The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis	343
Markers of inflammation and their association with muscle strength and mass: A systematic review and meta-analysis	315
A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks	306
A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration	278
Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?	245
Oxidative stress: The core pathogenesis and mechanism of Alzheimer’s disease	239
Oxidative stress and regulated cell death in Parkinson’s disease	211
Sarcopenia – Molecular mechanisms and open questions	210
Defective mitophagy in Alzheimer’s disease	189
Synaptic basis of Alzheimer’s disease: Focus on synaptic amyloid beta, P-tau and mitochondria	185
Combined physical and cognitive training for older adults with and without cognitive impairment: A systematic review and network meta-analysis of randomized controlled trials	173
Western diet as a trigger of Alzheimer’s disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration	170
Stress and telomere shortening: Insights from cellular mechanisms	169
Past, present and future of therapeutic strategies against amyloid-β peptides in Alzheimer’s disease: a systematic review	162
Role of mitochondrial quality surveillance in myocardial infarction: From bench to bedside	159
Nrf2: a dark horse in Alzheimer's disease treatment	152
Hypoxia and brain aging: Neurodegeneration or neuroprotection?	147
Autophagy in Alzheimer’s disease pathogenesis: Therapeutic potential and future perspectives	146
The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: From antioxidant to epigenetic therapy	141
Biomarkers shared by frailty and sarcopenia in older adults: A systematic review and meta-analysis	141
Autophagy and the hallmarks of aging	140
Healthful aging mediated by inhibition of oxidative stress	138
Effects of monoclonal antibodies against amyloid-β on clinical and biomarker outcomes and adverse event risks: A systematic review and meta-analysis of phase III RCTs in Alzheimer’s disease	138
The association of objectively measured physical activity and sedentary behavior with skeletal muscle strength and muscle power in older adults: A systematic review and meta-analysis	134

Branched chain amino acids, aging and age-related health	128
Prevention of dementia in an ageing world: Evidence and biological rationale	125
Mitochondrial dysfunction, oxidative stress, neuroinflammation, and metabolic alterations in the progression of Alzheimer’s disease: A meta-analysis of in vivo magnetic resonance spectroscopy studies	123
The involvement of NLRP3 inflammasome in the treatment of Alzheimer’s disease	122
Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases	122
Novel target for treating Alzheimer’s Diseases: Crosstalk between the Nrf2 pathway and autophagy	117
miR-21 and miR-146a: The microRNAs of inflammaging and age-related diseases	114
Mitochondria in Ovarian Aging and Reproductive Longevity	109
Single-cell analyses of aging, inflammation and senescence	109
Neuronal excitation/inhibition imbalance: core element of a translational perspective on Alzheimer pathophysiology	105
Mitochondria: Their relevance during oocyte ageing	104
Cross-sectional and longitudinal associations between adherence to Mediterranean diet with physical performance and cognitive function in older adults: A systematic review and meta-analysis	104
Obesity and aging: Molecular mechanisms and therapeutic approaches	102
Optimal dose and type of exercise to improve cognitive function in older adults: A systematic review and bayesian model-based network meta-analysis of RCTs	101
Prevalence of multidimensional frailty and pre-frailty in older people in different settings: A systematic review and meta-analysis	101
Autophagy in the diabetic heart: A potential pharmacotherapeutic target in diabetic cardiomyopathy	97
Modifiable lifestyle factors and cognitive reserve: A systematic review of current evidence	97
Targeting immune dysfunction in aging	97
Updated systematic review and meta-analysis on diagnostic issues and the prognostic impact of myosteatosis: A new paradigm beyond sarcopenia	96
Inflammatory pathways in Alzheimer’s disease mediated by gut microbiota	90
The role of nutrition in inflammaging	89
Ageing of the gut microbiome: Potential influences on immune senescence and inflammageing	89
Cellular senescence in knee osteoarthritis: molecular mechanisms and therapeutic implications	89
The ageing kidney: Molecular mechanisms and clinical implications	89
Omics sciences for systems biology in Alzheimer’s disease: State-of-the-art of the evidence	88
Home-based exercise programmes improve physical fitness of healthy older adults: A PRISMA-compliant systematic review and meta-analysis with relevance for COVID-19	86
Biological and environmental predictors of heterogeneity in neurocognitive ageing	84
Olfactory dysfunction in aging and neurodegenerative diseases	83
Biomarkers used in Alzheimer’s disease diagnosis, treatment, and prevention	83
Short-chain fatty acid metabolism and multiple effects on cardiovascular diseases	83
Benefits and harms of exercise therapy in people with multimorbidity: A systematic review and meta-analysis of randomised controlled trials	82
The hoverfly and the wasp: A critique of the hallmarks of aging as a paradigm	80
The emerging role of exosomes in Alzheimer’s disease	79
Elastic fibers during aging and disease	78
The role of Nrf2 in neural stem/progenitors cells: From maintaining stemness and self-renewal to promoting differentiation capability and facilitating therapeutic application in neurodegenerative dise	78
Epigenetic regulation of melanogenesis	77
Epigenetic clock: A promising biomarker and practical tool in aging	76
DNA methylation-based age clocks: From age prediction to age reversion	76
Reactive astrocytes: The nexus of pathological and clinical hallmarks of Alzheimer’s disease	75
COVID-19: risk accumulation among biologically and socially vulnerable older populations	74
Inflammaging, hormesis and the rationale for anti-aging strategies	73
Is personality associated with dementia risk? A meta-analytic investigation	72
Deregulated mitochondrial microRNAs in Alzheimer's disease: Focus on synapse and mitochondria	71
Frailty prevalence and impact on outcomes in patients with atrial fibrillation: A systematic review and meta-analysis of 1,187,000 patients	70
PINK1/Parkin-mediated mitophagy in neurodegenerative diseases	69
Diabetes mellitus and hearing loss: A review	68
The accelerated aging phenotype: The role of race and social determinants of health on aging	68
Osteocytes in bone aging: Advances, challenges, and future perspectives	68
From DNA damage to mutations: All roads lead to aging	67
Dysbiosis, malnutrition and enhanced gut-lung axis contribute to age-related respiratory diseases	67

A common signature of cellular senescence; does it exist?	66
Re-emphasizing early Alzheimer’s disease pathology starting in select entorhinal neurons, with a special focus on mitophagy	66
The hyperfunction theory: An emerging paradigm for the biology of aging	66
Neurogenesis in aging and age-related neurodegenerative diseases	65
The geroscience agenda: Toxic stress, hormetic stress, and the rate of aging	65
Mitochondrial dysfunction in aging	64
Iron homeostasis and organismal aging	64
Exercise interventions in Alzheimer’s disease: A systematic review and meta-analysis of randomized controlled trials	64
Fibroageing: An ageing pathological feature driven by dysregulated extracellular matrix-cell mechanobiology	63
Social hallmarks of aging: Suggestions for geroscience research	63
Deterioration of nuclear morphology and architecture: A hallmark of senescence and aging	63
The protective role of exercise against age-related neurodegeneration	63
Promising biomarkers of human aging: In search of a multi-omics panel to understand the aging process from a multidimensional perspective	62
Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders	61
Glial cells in Alzheimer’s disease: From neuropathological changes to therapeutic implications	60
An elusive consensus definition of sarcopenia impedes research and clinical treatment: A narrative review	60
The role of the immune system in Alzheimer’s disease	60
Role of indoleamine 2,3-dioxygenase 1 (IDO1) and kynurenine pathway in the regulation of the aging process	60
Identification of altered exosomal microRNAs and mRNAs in Alzheimer's disease	58
GDF15, an emerging key player in human aging	58
Calorie restriction for enhanced longevity: The role of novel dietary strategies in the present obesogenic environment	58
The neurobiology of non-coding RNAs and Alzheimer’s disease pathogenesis: Pathways, mechanisms and translational opportunities	57
Post-translational modifications: Regulators of neurodegenerative proteinopathies	56
Retinal biomarkers in Alzheimer’s disease and mild cognitive impairment: A systematic review and meta-analysis	56
Role of Nrf2 in aging, Alzheimer’s and other neurodegenerative diseases	55
Attenuation of 7-ketocholesterol- and 7β-hydroxycholesterol-induced oxiapoptophagy by nutrients, synthetic molecules and oils: Potential for the prevention of age-related diseases	54
The complex associations between late life depression, fear of falling and risk of falls. A systematic review and meta-analysis	54
Monoamine oxidases in age-associated diseases: New perspectives for old enzymes	54
COVID-19 mortality as a fingerprint of biological age	54
The role of serotonin within the microbiota-gut-brain axis in the development of Alzheimer’s disease: A narrative review	54
Brain lipid peroxidation and alzheimer disease: Synergy between the Butterfield and Mattson laboratories	54
Research progress in the use of mesenchymal stem cells and their derived exosomes in the treatment of osteoarthritis	53
Associations between nutrition and the incidence of depression in middle-aged and older adults: A systematic review and meta-analysis of prospective observational population-based studies	53
Effects of exergames and cognitive-motor dual-task training on cognitive, physical and dual-task functions in cognitively healthy older adults: An overview	53
Potential roles of gut microbiota and microbial metabolites in Parkinson’s disease	53
Exploring ER stress response in cellular aging and neuroinflammation in Alzheimer's disease	52
The dialogue between the ubiquitin-proteasome system and autophagy: Implications in ageing	52
Exosome: A novel neurotransmission modulator or non-canonical neurotransmitter?	52
The Role of Rapamycin in Healthspan Extension via the Delay of Organ Aging	51
Pleiotropic effects of alpha-ketoglutarate as a potential anti-ageing agent	51
Does oxidative stress shorten telomeres in vivo? A meta-analysis	51
Aging adipose: Depot location dictates age-associated expansion and dysfunction	51
Iron homeostasis in arthropathies: From pathogenesis to therapeutic potential	50
lncRNA NEAT1: Key player in neurodegenerative diseases	50
Toward noninvasive brain stimulation 2.0 in Alzheimer’s disease	50
Age-related changes in muscle architecture and metabolism in humans: The likely contribution of physical inactivity to age-related functional decline	50
Defining and assessing intrinsic capacity in older people: A systematic review and a proposed scoring system	49
Artificial intelligence in brain MRI analysis of Alzheimer’s disease over the past 12 years: A systematic review	49
The emerging role of the sympathetic nervous system in skeletal muscle motor innervation and sarcopenia	49
Curcumin nanoformulations to combat aging-related diseases	49
Frailty is highly prevalent in specific cardiovascular diseases and females, but significantly worsens prognosis in all affected patients: A systematic review	49
New insights into the interplay between miRNAs and autophagy in the aging of intervertebral discs	49
Lipocalin 2 as a link between ageing, risk factor conditions and age-related brain diseases	48
Cerebral blood flow in mild cognitive impairment and Alzheimer’s disease: A systematic review and meta-analysis	47
Interactions between glial cells and the blood-brain barrier and their role in Alzheimer's disease	46
Mechanosensing dysregulation in the fibroblast: A hallmark of the aging heart	46
Time-restricted feeding (TRF) for prevention of age-related vascular cognitive impairment and dementia	46
Unsupervised home-based resistance training for community-dwelling older adults: A systematic review and meta-analysis of randomized controlled trials	46
Hormesis and Ginkgo biloba (GB): Numerous biological effects of GB are mediated via hormesis	45
How good is the evidence that cellular senescence causes skin ageing?	45
A systematic review of the impacts of intergenerational engagement on older adults’ cognitive, social, and health outcomes	45
Aging-suppressor Klotho: Prospects in diagnostics and therapeutics	45
Heart rate variability in relation to cognition and behavior in neurodegenerative diseases: A systematic review and meta-analysis	45
Efficacy of non-invasive brain stimulation on global cognition and neuropsychiatric symptoms in Alzheimer’s disease and mild cognitive impairment: A meta-analysis and systematic review	44
Fatigue and the prediction of negative health outcomes: A systematic review with meta-analysis	44
Roles of clock genes in the pathogenesis of Parkinson's disease	44
Physical activity for cognitive health promotion: An overview of the underlying neurobiological mechanisms	44
Prevalence of unwillingness and uncertainty to vaccinate against COVID-19 in older people: A systematic review and meta-analysis	43
Risk factors for falls in older people with cognitive impairment living in the community: Systematic review and meta-analysis	43
Nutritional domains in frailty tools: Working towards an operational definition of nutritional frailty	43
Sarcopenia definition: Does it really matter? Implications for resistance training	43
Fostering healthy aging: The interdependency of infections, immunity and frailty	42
Diagnostic performance of digital cognitive tests for the identification of MCI and dementia: A systematic review	42
Premotor, nonmotor and motor symptoms of Parkinson's Disease: A new clinical state of the art	42
Salivary biomarkers of neurodegenerative and demyelinating diseases and biosensors for their detection	42
Socially assistive robots for people with dementia: Systematic review and meta-analysis of feasibility, acceptability and the effect on cognition, neuropsychiatric symptoms and quality of life	41
Recent advances in the field of caloric restriction mimetics and anti-aging molecules	41
Formaldehyde toxicity in age-related neurological dementia	41
Emerging pathogenic role of peripheral blood factors following BBB disruption in neurodegenerative disease	40
Anthocyanin as a therapeutic in Alzheimer’s disease: A systematic review of preclinical evidences	40

Antidiabetic agents as a novel treatment for Alzheimer’s and Parkinson’s disease	40
Senescence in tissue samples of humans with age-related diseases: A systematic review	40
Melatonin: A novel candidate for the treatment of osteoarthritis	40
Hippuric acid: Could became a barometer for frailty and geriatric syndromes?	40
Nanomedical approaches in the realm of rheumatoid arthritis	39
Reducing neuroinflammation via therapeutic compounds and lifestyle to prevent or delay progression of Parkinson’s disease	39
The effect of Tai Chi in elderly individuals with sarcopenia and frailty: A systematic review and meta-analysis of randomized controlled trials	39
Feed-forward regulation between cellular senescence and immunosuppression promotes the aging process and age-related diseases	39
Artificial intelligence in elderly healthcare: A scoping review	39
The impact of aerobic and resistance training intensity on markers of neuroplasticity in health and disease	39
The potential role of melatonin in retarding intervertebral disc ageing and degeneration: A systematic review	38
Does eNOS derived nitric oxide protect the young from severe COVID-19 complications?	38
Mechanisms linking mitochondrial mechanotransduction and chondrocyte biology in the pathogenesis of osteoarthritis	38
Multi-omics research in sarcopenia: Current progress and future prospects	38
Socioeconomic position and healthy ageing: A systematic review of cross-sectional and longitudinal studies	37
Cortisol hypersecretion and the risk of Alzheimer’s disease: A systematic review and meta-analysis	37
Irisin, an exercise-induced bioactive peptide beneficial for health promotion during aging process	37
Thymus involution sets the clock of the aging T-cell landscape: Implications for declined immunity and tissue repair	36
Therapy for Alzheimer’s disease: Missing targets and functional markers?	36
Targeting metabolic pathways for extension of lifespan and healthspan across multiple species	36
Abnormal white matter changes in Alzheimer's disease based on diffusion tensor imaging: A systematic review	35
Noncoding RNAs in age-related cardiovascular diseases	35
Searching for the link between inflammaging and sarcopenia	35
Senescent cells as promising targets to tackle age-related diseases	35
Fight to the bitter end: DNA repair and aging	35
Major depression and the biological hallmarks of aging	35
From beta amyloid to altered proteostasis in Alzheimer’s disease	35
The hormetic and hermetic role of IL-6	35
Region-specific vulnerability in neurodegeneration: lessons from normal ageing	35
Structure-functional implications of longevity protein p66Shc in health and disease	35
Transcranial magnetic stimulation (TMS) for geriatric depression	35
Dissecting primary and secondary senescence to enable new senotherapeutic strategies	34
Vascular dementia: A microglia's perspective	33
Frailty biomarkers under the perspective of geroscience: A narrative review	33
Exploring the multifunctional role of melatonin in regulating autophagy and sleep to mitigate Alzheimer’s disease neuropathology	33
The prevalence of frailty and pre-frailty among geriatric hospital inpatients and its association with economic prosperity and healthcare expenditure: A systematic review and meta-analysis of 467,779	33
Stepping impairment and falls in older adults: A systematic review and meta-analysis of volitional and reactive step tests	33
Blood pressure variability: A potential marker of aging	33
Prevalence of dementia in Latin America and Caribbean countries: Systematic review and meta-analyses exploring age, sex, rurality, and education as possible determinants	33
Systemic manifestation and contribution of peripheral tissues to Huntington’s disease pathogenesis	33
Environmental factors and risks of cognitive impairment and dementia: A systematic review and meta-analysis	33
Altered endocytosis in cellular senescence	33
Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer’s disease: Past, present and future	33
Emerging potential of cannabidiol in reversing proteinopathies	32
Efficacy of vitamin D3 supplementation on cancer mortality: Systematic review and individual patient data meta-analysis of randomised controlled trials	32
New era of artificial intelligence and machine learning-based detection, diagnosis, and therapeutics in Parkinson’s disease	32
Methionine as a double-edged sword in health and disease: Current perspective and future challenges	32
Roles and mechanisms of MFG-E8 in vascular aging-related diseases	32
Behavioral and Social Research to Accelerate the Geroscience Translation Agenda	32
Brain drug delivery and neurodegenerative diseases: Polymeric PLGA-based nanoparticles as a forefront platform	32
Can exercise training teach us how to treat Alzheimer’s disease?	32
Neurotransmitter systems in the etiology of major neurological disorders: Emerging insights and therapeutic implications	31
Glutathione and glutathione-dependent enzymes: From biochemistry to gerontology and successful aging	31
The mitochondrial unfolded protein response: A multitasking giant in the fight against human diseases	31
Female specific risk factors for the development of Alzheimer’s disease neuropathology and cognitive impairment: Call for a precision medicine approach	31
Associations of dietary markers with brain volume and connectivity: A systematic review of MRI studies	31
Stem cell aging in the skeletal muscle: The importance of communication	31
Ageing mechanisms that contribute to tissue remodeling in lung disease	30
Emerging role of aging in the progression of NAFLD to HCC	30
Associations of Omega-3 fatty acids with brain morphology and volume in cognitively healthy older adults: A narrative review	30
Abnormal amyloid beta metabolism in systemic abnormalities and Alzheimer’s pathology: Insights and therapeutic approaches from periphery	30
60 years of healthy aging: On definitions, biomarkers, scores and challenges	30
Neurobiology of depression in Parkinson’s disease: Insights into epidemiology, molecular mechanisms and treatment strategies	30
Protein intake and physical function in older adults: A systematic review and meta-analysis	30
Thresholds of handgrip strength for all-cause, cancer, and cardiovascular mortality: A systematic review with dose-response meta-analysis	30
Fractal dimension of the brain in neurodegenerative disease and dementia: A systematic review	30
Protein S-sulfhydration: Unraveling the prospective of hydrogen sulfide in the brain, vasculature and neurological manifestations	30
Sirtuins, resveratrol and the intertwining cellular pathways connecting them	30
β-amyloid: The known unknowns	30
Gut microbiota as a promising therapeutic target for age-related sarcopenia	29
Breakdown of specific functional brain networks in clinical variants of Alzheimer’s disease	29
Underrepresentation of older adults in clinical trials on COVID-19 vaccines: A systematic review	29
Resilience in older persons: A systematic review of the conceptual literature	29
Telomere length and brain aging: A systematic review and meta-analysis	29
Non-alcoholic fatty liver disease-related fibrosis and sarcopenia: An altered liver-muscle crosstalk leading to increased mortality risk	29
Estimates of malnutrition and risk of malnutrition among the elderly (≥60 years) in India: A systematic review and meta-analysis	29
Understanding the involvement of innate immunity and the Nrf2-NLRP3 axis on mitochondrial health in Parkinson's disease	29
Photobiomodulation for the aging brain	28
Differential gut microbiota and intestinal permeability between frail and healthy older adults: A systematic review	28
Transposable elements in brain health and disease	28
Bidirectional roles of skeletal muscle fibro-adipogenic progenitors in homeostasis and disease	28
Linking circadian rhythms to microbiome-gut-brain axis in aging-associated neurodegenerative diseases	28
Interplay between aging and other factors of the pathogenesis of age-related macular degeneration	28
Metabolic reprogramming and polarization of microglia in Parkinson’s disease: Role of inflammasome and iron	27
Ferroptosis in Parkinson's disease: Molecular mechanisms and therapeutic potential	27
Hydrogen sulfide in longevity and pathologies: Inconsistency is malodorous	27
The role of nerve fibers and their neurotransmitters in regulating intervertebral disc degeneration	27
Immunosenescence and inflamm-ageing in COVID-19	27
From corpora amylacea to wasteosomes: History and perspectives	27
Affective symptoms and risk of progression to mild cognitive impairment or dementia in subjective cognitive decline: A systematic review and meta-analysis	27
MicroRNAs in the regulation of autophagy and their possible use in age-related macular degeneration therapy	27
Assessing the rate of aging to monitor aging itself	27
Immunometabolic responses according to physical fitness status and lifelong exercise during aging: New roads for exercise immunology	27
Biomarkers of ageing and frailty may predict COVID-19 severity	27
Pharmaceutical and nutraceutical activation of FOXO3 for healthy longevity	27