Ageing Research Reviews

Article	Citations
Start the engine of neuroregeneration: A mechanistic and strategic overview of direct astrocyte-to-neuron reprogramming	542
Editorial Board	407
Adenosine metabolism and receptors in aging of the skin, musculoskeletal, immune and cardiovascular systems	273
Roles of hypoxia-inducible factor-prolyl hydroxylases in aging and disease	267
Microglia and gut microbiota: A double-edged sword in Alzheimer's disease	262
Efficacy of technology-based cognitive and exercise interventions for mild cognitive impairment: A systematic review, network meta-analysis, and meta-regression of randomized controlled trials	242
Advances in clinical application of lipidomics in healthy ageing and healthy longevity medicine	232
Prevalence and health outcomes of polypharmacy and hyperpolypharmacy in older adults with frailty: A systematic review and meta-analysis	224
Effectiveness of virtual reality interventions on quality of life, cognitive function and physical function in older people with Alzheimer's disease: A systematic review	222
Can dementia risk be reduced by following the American Heart Association's Life's Simple 7? A systematic review and dose-response meta-analysis	218
Artificial intelligence in brain MRI analysis of Alzheimer’s disease over the past 12 years: A systematic review	211
Editorial Board	194
Unravelling the brain resilience following stroke: From injury to rewiring of the brain through pathway activation, drug targets, and therapeutic interventions	173
Unraveling the protein post-translational modification landscape: Neuroinflammation and neuronal death after stroke	172
CC chemokines family in fibrosis and aging: From mechanisms to therapy	168
Vascular cognitive impairment – Past, present, and future challenges	167
The unique neuropathological vulnerability of the human brain to aging	166
Dysfunction of norepinephrine and its metabolites in Alzheimer's dementia – A review with meta-analysis	151
Discovery of a new hereditary RECQ helicase disorder RECON syndrome positions the replication stress response and genome homeostasis as centrally important processes in aging and age-related disease	142
The functions of IRE1α in neurodegenerative diseases: Beyond ER stress	142
Repetitive transcranial magnetic stimulation combined with cognitive training for cognitive function and activities of daily living in patients with post-stroke cognitive impairment: A systematic revi	140
Thioredoxin-1 inhibits the activation of IRE1 by targeting Hsp90/p-Cdc37 chaperone complex in Parkinson disease	132
Rethinking IRPs/IRE system in neurodegenerative disorders: Looking beyond iron metabolism	131
Editorial Board	128
Histopathological and ultrastructural changes in different cell types during ischemic and hemorrhagic stroke	123

Advances in Alzheimer's therapy: Exploring neuropathological mechanisms to revolutionize the future therapeutic landscape	121
Medication reviews in hospitalised patients for reduced hospital readmission and mortality. Systematic review, meta-analysis and meta-regression of RCTs	119
Sarcobesity: New paradigms for healthy aging related to taurine supplementation, gut microbiota and exercise	119
Type 2 diabetes mellitus augments Parkinson’s disease risk or the other way around: Facts, challenges and future possibilities	118
DNA methylation in genes associated with the evolution of ageing and disease: A critical review	118
Optimal dose and type of exercise to improve cognitive function in older adults: A systematic review and bayesian model-based network meta-analysis of RCTs	117
How good is the evidence that cellular senescence causes skin ageing?	116
Global, regional, and national burden of spinal cord injury from 1990 to 2021 and projections for 2050: A systematic analysis for the Global Burden of Disease 2021 study	116
Does drug repurposing bridge the gaps in management of Parkinson’s disease? Unravelling the facts and fallacies	115
Involvement of regulated cell deaths in aging and age-related pathologies	111
Biomarkers associated with cognitive impairment in post-traumatic stress disorder: A systematic review of current evidence	109
Transcranial direct current stimulation combined with motor training for motor symptoms in Parkinson's disease: A systematic review and meta-analysis	108
Potential convergence of olfactory dysfunction in Parkinson’s disease and COVID-19: The role of neuroinflammation	108
Targeting aging with urolithin A in humans: A systematic review	108
Research progress in Alzheimer's disease and bone-brain axis	105
Sensory nerve regulation of bone homeostasis: Emerging therapeutic opportunities for bone-related diseases	103
Advances of artificial intelligence in predicting frailty using real-world data: A scoping review	103
HMGB1, an evolving pleiotropic protein critical for cellular and tissue homeostasis: Role in aging and age-related diseases	103
Role of diet and exercise in aging, Alzheimer’s disease, and other chronic diseases	98
Searching for the link between inflammaging and sarcopenia	98
Adherence to the Mediterranean diet and risk of frailty and pre-frailty in elderly adults: A systematic review and dose-response meta-analysis with GRADE assessment	97
Characterization of the logopenic variant of Primary Progressive Aphasia: A systematic review and meta-analysis	97
Cytosolic DNA sensor IFI16 proteins: Potential molecular integrators of interactions among the aging hallmarks	96
Bridging neurotrophic factors and bioactive peptides to Alzheimer's disease	95
On the wake of metformin: Do anti-diabetic SGLT2 inhibitors exert anti-aging effects?	94
The several ways to authentically cure Alzheimer’s dementia	93
The role of the PLA2G6 gene in neurodegenerative diseases	92
Triaging between post-translational modification of cell cycle regulators and their therapeutics in neurodegenerative diseases	92
Betaine and aging: A narrative review of findings, possible mechanisms, research perspectives, and practical recommendations	90
Interventions to prevent and treat delirium: An umbrella review of randomized controlled trials	90
Cognitive resilience in Alzheimer’s disease: Mechanism and potential clinical intervention	90
The mitochondrial integrated stress response: A novel approach to anti-aging and pro-longevity	89
Overview of pro-inflammatory and pro-survival components in neuroinflammatory signalling and neurodegeneration	88
Hallmarks of aging: A user’s guide for comparative biologists	88
The effectiveness of dance movement interventions for older adults with mild cognitive impairment, Alzheimer’s disease, and dementia: A systematic scoping review and meta-analysis	87
New era of artificial intelligence and machine learning-based detection, diagnosis, and therapeutics in Parkinson’s disease	83
The link between metabolic syndrome and Alzheimer disease: A mutual relationship and long rigorous investigation	83
Associations of olfactory function with brain structural and functional outcomes. A systematic review	82
Melatonin: Potential avenue for treating iron overload disorders	82
Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseases	80
Modifiable lifestyle factors and cognitive reserve: A systematic review of current evidence	80
Neuroprotection by agmatine: Possible involvement of the gut microbiome?	80
Identification of exosomal biomarkers and its optimal isolation and detection method for the diagnosis of Parkinson's disease: A systematic review and meta-analysis	79
Molecular hydrogen therapy: A “democratic” emerging strategy against aging and age-related diseases	79
A Multimodal Meta-Analytical Evidence of Functional and Structural Brain Abnormalities Across Alzheimer's Disease Spectrum	79
Latest developments of microphysiological systems (MPS) in aging-related and geriatric diseases research: A review	78
Intracellular effects of lithium in aging neurons	77
ADP-ribosylation, a multifaceted modification: Functions and mechanisms in aging and aging-related diseases	76
The effect of ferroptosis-related mitochondrial dysfunction in the development of temporal lobe epilepsy	75
The cross-talk between the cGAS-STING signaling pathway and chronic inflammation in the development of musculoskeletal disorders	75

Association of frailty and pre-frailty with all-cause and cardiovascular mortality in diabetes: Three prospective cohorts and a meta-analysis	75
Regulated cell death in acute myocardial infarction: Molecular mechanisms and therapeutic implications	75
Biological constraint, evolutionary spandrels and antagonistic pleiotropy	75
Long-term human spaceflight and inflammaging: Does it promote aging?	74
Oral health indicators and bone mineral density disorders in older age: A systematic review	74
Aryl hydrocarbon receptor: From pathogenesis to therapeutic targets in aging-related tissue fibrosis	73
Modulators of ASIC1a and its potential as a therapeutic target for age-related diseases	73
The plasticity of fibroblasts: A forgotten player in the aging process	73
Suicide and dementia: A systematic review and meta-analysis of prevalence and risk factors	73
The future of stem cell therapies of Alzheimer’s disease	73
Expanding evolutionary theories of ageing to better account for symbioses and interactions throughout the Web of Life	73
Turquoise killifish: A natural model of age-dependent brain degeneration	73
A novel regulator in Alzheimer's disease progression: The astrocyte-derived extracellular vesicles	73
Beyond the Hayflick limit: How microbes influence cellular aging	73
Affective symptoms and risk of progression to mild cognitive impairment or dementia in subjective cognitive decline: A systematic review and meta-analysis	72
Under the umbrella of depression and Alzheimer’s disease physiopathology: Can cannabinoids be a dual-pleiotropic therapy?	72
Healthy brain aging and delayed dementia in Texas rural elderly	71
Computerized cognitive training in Parkinson’s disease: A systematic review and meta-analysis	70
Unravelling of molecular biomarkers in synaptic plasticity of Alzheimer’s disease: Critical role of the restoration of neuronal circuits	70
Drug repositioning for Parkinson’s disease: An emphasis on artificial intelligence approaches	69
Modifiable risk factors for mild cognitive impairment among cognitively normal community-dwelling older adults: A systematic review and meta-analysis	68
Exercise interventions in Alzheimer’s disease: A systematic review and meta-analysis of randomized controlled trials	68
The role of exercise in the prevention and treatment of Alzheimer’s disease and mild cognitive impairments	68
Targeting the gut microbiota-related metabolites for osteoporosis: The inextricable connection of gut-bone axis	67
Current research status of blood biomarkers in Alzheimer’s disease: Diagnosis and prognosis	67
A critical appraisal of blood-based biomarkers for Alzheimer’s disease	67
Role of Nrf2 in aging, Alzheimer’s and other neurodegenerative diseases	67
Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer’s disease: Past, present and future	66
Genetic mechanisms of aging in plants: What can we learn from them?	66
Interactions between glial cells and the blood-brain barrier and their role in Alzheimer's disease	66
cGAS-STING targeting offers novel therapeutic opportunities in neurological diseases	66
From onset to advancement: the temporal spectrum of α-synuclein in synucleinopathies	64
Mortality prediction models for community-dwelling older adults: A systematic review	64
Restoration of epigenetic impairment in the skeletal muscle and chronic inflammation resolution as a therapeutic approach in sarcopenia	64
Association between pulse wave velocity and white matter hyperintensities among older adults: A meta-analysis of cross-sectional and longitudinal studies	64
Unlocking the potential of histone deacetylase inhibitors in combatting age-related retinal degenerative diseases	64
The memory- and cognition-facilitating effects of spermidine in aging and aging-related disorders	64
Alzheimer's disease and Alzheimer’s disease-related dementias in Hispanics: Identifying influential factors and supporting caregivers	63
Antioxidants in anti‐Alzheimer's disease drug discovery	63
Recent advancement in understanding of Alzheimer's disease: Risk factors, subtypes, and drug targets and potential therapeutics	63
The metabolic and endocrine impact of diet-derived gut microbiota metabolites on ageing and longevity	63
Telomere length and brain aging: A systematic review and meta-analysis	63
Small molecule modulators of alpha-synuclein aggregation and toxicity: Pioneering an emerging arsenal against Parkinson’s disease	61
From corpora amylacea to wasteosomes: History and perspectives	60
Hormesis defines the limits of lifespan	60
A tale of two systems: Lessons learned from female mid-life aging with implications for Alzheimer’s prevention & treatment	60
BACE1-dependent metabolism of neuregulin 1: Bridging the gap in explaining the occurrence of schizophrenia-like symptoms in Alzheimer's disease with psychosis?	60
Editorial Board	60
Association between lipocalin-2 and mild cognitive impairment or dementia: A systematic review and meta-analysis of population-based evidence	60
A review on neurodegeneration in the fast-ageing killifish, the first animal model to study the natural occurrence of neuronal cell loss	59
Resolution of inflammation, an active process to restore the immune microenvironment balance: A novel drug target for treating arterial hypertension	58
The mechanism of cuproptosis in Parkinson’s disease	58
Is COVID-19 really a geriatric syndrome?	58
Aryl hydrocarbon receptor (AhR) impairs circadian regulation: Impact on the aging process	58
Global burden, risk factors, and projections of early-onset dementia: Insights from the Global Burden of Disease Study 2021	57
The mechanisms of mitochondrial abnormalities that contribute to sleep disorders and related neurodegenerative diseases	57
Consolidating multiple evolutionary theories of ageing suggests a need for new approaches to study genetic contributions to ageing decline	57
Editorial Board	55
Underserved groups in dysphagia intervention trials in Parkinson’s disease: A scoping review	55
Long-term fasting and its influence on inflammatory biomarkers: A comprehensive scoping review	55
Brain drug delivery and neurodegenerative diseases: Polymeric PLGA-based nanoparticles as a forefront platform	55
Transposable elements and their role in aging	55
Modulating α-synuclein propagation and decomposition: Implications in Parkinson's disease therapy	55
Neurobiology of depression in Parkinson’s disease: Insights into epidemiology, molecular mechanisms and treatment strategies	55
Blood pressure variability: A potential marker of aging	54
Prevalence of psychotic symptoms in mild cognitive impairment: A systematic review and meta-analysis	54
FAM19A5 in vascular aging and osteoporosis: Mechanisms and the “calcification paradox”	53
Cerebellar pathology in forensic and clinical neuroscience	53
Fractal dimension of the brain in neurodegenerative disease and dementia: A systematic review	53
Breakdown of specific functional brain networks in clinical variants of Alzheimer’s disease	53
Multi-omics strategies to decode the molecular landscape of cellular senescence	53
Cerebral small vessel disease pathology in COVID-19 patients: A systematic review	53
RNA binding proteins in senescence: A potential common linker for age-related diseases?	53
Epigenetic biomarkers in Alzheimer's disease: Diagnostic and prognostic relevance	53
Effect of ketogenic diets on insulin-like growth factor (IGF)-1 in humans: A systematic review and meta-analysis	52
Widowhood and cognitive decline in adults aged 50 and over: A systematic review and meta-analysis	52
Associations between vision impairment and eye diseases with dementia, dementia subtypes and cognitive impairment: An umbrella review	52
Impact of frailty on all-cause mortality or major amputation in patients with lower extremity peripheral artery disease: A meta-analysis	52
Single-cell sequencing insights into the transcriptional landscape of Parkinson's disease	52
Biological resilience and aging: Activation of stress response pathways contributes to lifespan extension	51

Heat stroke: Pathogenesis, diagnosis, and current treatment	51
Oxidative stress: The core pathogenesis and mechanism of Alzheimer’s disease	51
The senotherapeutic potential of phytochemicals for age-related intestinal disease	51
Understanding age-related pathologic changes in TDP-43 functions and the consequence on RNA splicing and signalling in health and disease	51
Mitochondrial transfer between cell crosstalk – An emerging role in mitochondrial quality control	51
Glial cells in Alzheimer’s disease: From neuropathological changes to therapeutic implications	51
Impact of exercise intervention-based changes on physical function biomarkers in older adults after hospital discharge: A systematic review with meta-analysis of randomized clinical trials	51
Exploring Parkinson-associated kinases for CRISPR/Cas9-based gene editing: beyond alpha-synuclein	51
The role of nutrition in inflammaging	51
Efficacy of rehabilitation robot-assisted gait training on lower extremity dyskinesia in patients with Parkinson's disease: A systematic review and meta-analysis	51
Resolving the current controversy of use and reuse of housekeeping proteins in ageing research: Focus on saving people’s tax dollars	50
Markers of biological age in dogs	50
The role of oxidative stress in intervertebral disc degeneration: Mechanisms and therapeutic implications	49
Effects of exercise interventions on cognitive functions in healthy populations: A systematic review and meta-analysis	49
The interplay of NAD and hypoxic stress and its relevance for ageing	49
Epigenetic clock: A promising biomarker and practical tool in aging	49
The conceivable role of prolactin hormone in Parkinson disease: The same goal but with different ways	49
Editorial Board	48
MSC-EVs alleviate osteoarthritis by regulating microenvironmental cells in the articular cavity and maintaining cartilage matrix homeostasis	48
Towards a comprehensive framework for complex walking tasks: Characterization, behavioral adaptations, and clinical implications in ageing and neurological populations	48
Multi-omics research strategies in ischemic stroke: A multidimensional perspective	48
The prognostic impacts of frailty on clinical and patient-reported outcomes in patients undergoing coronary artery or valvular surgeries/procedures: A systematic review and meta-analysis	47
Editorial Board	47
Editorial Board	47
Deciphering the mechanistic impact of acupuncture on the neurovascular unit in acute ischemic stroke: Insights from basic research in a narrative review	47
Updates on brain regions and neuronal circuits of movement disorders in Parkinson’s disease	47
Targeting impaired nutrient sensing via the sirtuin pathway with novel compounds to prevent or treat dementia: A systematic review	47
Osteosarcopenic adiposity (OSA) phenotype and its connection with cardiometabolic disorders: Is there a cause-and-effect?	46
Adipose tissue and ovarian aging: Potential mechanism and protective strategies	46
Is cognitive reserve associated with the prevention of cognitive decline after stroke? A Systematic review and meta-analysis	46
A cross-talk between sestrins, chronic inflammation and cellular senescence governs the development of age-associated sarcopenia and obesity	46
Pregnancy, preeclampsia and maternal aging: From epidemiology to functional genomics	46
The role of serotonin within the microbiota-gut-brain axis in the development of Alzheimer’s disease: A narrative review	45
Neurobiological role and therapeutic potential of exercise-induced irisin in Alzheimer's disease management	45
Cannabidiol and neurodegeneration: From molecular mechanisms to clinical benefits	45
Dementia, osteoporosis and fragility fractures: Intricate epidemiological relationships, plausible biological connections, and twisted clinical practices	45
Prevalence of alcohol use among U.S. older adults with pain: A scoping review	45
Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central nervous system	44
Precision neurology	43
The impact of aging on HIV-1-related neurocognitive impairment	43
Editorial Board	43
Osteoporosis and Alzheimer´s disease (or Alzheimer´s disease and Osteoporosis)	43
Reducing Alzheimer’s disease risk with SGLT2 inhibitors: From glycemic control to neuroprotection	42
Exploring cytokines dynamics: Uncovering therapeutic concepts for metabolic disorders in postmenopausal women- diabetes, metabolic bone diseases, and non-alcohol fatty liver disease	42
Role of UCHL1 in the pathogenesis of neurodegenerative diseases and brain injury	42
Unknown roles of tau pathology in neurological disorders. Challenges and new perspectives	42
Target modulation of glycolytic pathways as a new strategy for the treatment of neuroinflammatory diseases	42
Priorities in tackling noncommunicable diseases among the population aged 60 years and older in China, 1990–2021: A population-based study	42
Curcumin-loaded polymeric nanomaterials as a novel therapeutic strategy for Alzheimer's disease: A comprehensive review	41
Exerkines: Potential regulators of diabetic cardiomyopathy	41
Evolving landscape of colorectal cancer: Global and regional burden, risk factor dynamics, and future scenarios (the Global Burden of Disease 1990–2050)	41
Modulating the polarization phenotype of microglia – A valuable strategy for central nervous system diseases	41
The oral organ: A new vision of the mouth as a whole for a gerophysiological approach to healthy aging	41
Progress in the mechanisms of pain associated with neurodegenerative diseases	41
Reelin links Apolipoprotein E4, Tau, and Amyloid‐β in Alzheimer’s disease	41
Semaglutide as a possible therapy for healthy aging: Targeting the hallmarks of aging	40
Definitions of healthspan: A systematic review	40
Is it time to revise the fighting strategy toward type 2 diabetes? Sex and pollution as new risk factors	40
Immersive virtual reality for older adults: Challenges and solutions in basic research and clinical applications	40
Gut microbiome and Alzheimer’s disease: What we know and what remains to be explored	40
Macrophage membrane-camouflaged biomimetic nanovesicles for targeted treatment of arthritis	40
Emerging therapeutics agents and recent advances in drug repurposing for Alzheimer’s disease	40
Therapeutic potential of lipid nanosystems for the treatment of Parkinson’s disease	39
Rebalancing the unbalanced aged immune system – A special focus on zinc	39
Sarcopenia defined by the psoas muscle mass or quality is associated with poor survival in patients with aortic aneurysm undergoing surgery: A meta-analysis	39
Poly (ADP-ribose) polymerase 1 and neurodegenerative diseases: Past, present, and future	39
Pyroptosis: Mechanisms and links with diabetic cardiomyopathy	39
The hallmarks of aging in Ataxia-Telangiectasia	39
Developing transcriptomic signatures as a biomarker of cellular senescence	39
Harnessing two-dimensional nanomaterials for diagnosis and therapy in neurodegenerative diseases: Advances, challenges and prospects	38
Advances in human cellular mechanistic understanding and drug discovery of brain organoids for neurodegenerative diseases	38
Reply to “Caution in underrepresentation of older adults in clinical trials on COVID-19 vaccines”	38
The association of living alone and social isolation with sarcopenia: A systematic review and meta-analysis	38
Editorial Board	38
Advancements in computer-assisted diagnosis of Alzheimer's disease: A comprehensive survey of neuroimaging methods and AI techniques for early detection	37
Prevention of cardiovascular disease for healthy aging and longevity: A new scoring system and related “mechanisms-hallmarks-biomarkers”	37
Interlinked role of ASN, TDP-43 and Miro1 with parkinopathy: Focus on targeted approach against neuropathy in parkinsonism	37
Risk factors for multimorbidity in adulthood: A systematic review	37
Mapping the immune-genetic architecture of aging: A single-cell causal framework for biomarker discovery and therapeutic targeting	37
Immunometabolism and immune response regulate macrophage function in atherosclerosis	37
Motoric cognitive risk syndrome as a predictive factor of cognitive impairment and dementia – A systematic review and meta-analysis	36
Informal caregivers’ attitudes towards care robots: A mixed methods systematic review	35
Unraveling the mystery of citrate transporters in Alzheimer’s disease: An updated review	35
Sphk2 in ischemic stroke pathogenesis: Roles, mechanisms, and regulation strategies	34
Next-generation CRISPR gene editing tools in the precision treatment of Alzheimer’s and Parkinson’s disease	34
Neuropsychiatric disturbances in mild cognitive impairment: A scientometric analysis	34
Editorial Board	34
Is exposure to pesticides associated with biological aging? A systematic review and meta-analysis	34
Cognition on the move: Examining the role of physical exercise and neurogenesis in counteracting cognitive aging	34
Nanomedical approaches in the realm of rheumatoid arthritis	34
Physical activity and neurotrophic factors as potential drivers of neuroplasticity in Parkinson’s Disease: A systematic review and meta-analysis	34
Effect of long-term physical exercise and multidomain interventions on cognitive function and the risk of mild cognitive impairment and dementia in older adults: A systematic review with meta-analysis	34
The therapeutic potential of adiponectin and extracellular vesicles for promoting improved healthspan	34
Vitamin D and ischemic stroke - Association, mechanisms, and therapeutics	34
Biomarkers of aging in frailty and age-associated disorders: State of the art and future perspective	34