Ageing Research Reviews

Papers
(The median citation count of Ageing Research Reviews is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)
ArticleCitations
Cosmic chronometers: Is spaceflight a catalyst for biological ageing?976500490
Opening avenues for treatment of neurodegenerative disease using post-biotics: Breakthroughs and bottlenecks in clinical translation923415346
Impact of micronutrients and nutraceuticals on cognitive function and performance in Alzheimer's disease842019380
Sex biology in amyotrophic lateral sclerosis809120313
Aging in COVID-19: Vulnerability, immunity and intervention578
Biomarkers, oxidative stress and autophagy in skin aging302
The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis244
Markers of inflammation and their association with muscle strength and mass: A systematic review and meta-analysis241
A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks231
A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration197
Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?168
A multidimensional approach to frailty in older people165
Oxidative stress: The core pathogenesis and mechanism of Alzheimer’s disease157
Sarcopenia – Molecular mechanisms and open questions157
Oxidative stress and regulated cell death in Parkinson’s disease156
Synaptic basis of Alzheimer’s disease: Focus on synaptic amyloid beta, P-tau and mitochondria155
Exercise benefits on Alzheimer’s disease: State-of-the-science149
Defective mitophagy in Alzheimer’s disease149
Role of mitochondrial quality surveillance in myocardial infarction: From bench to bedside138
Combined physical and cognitive training for older adults with and without cognitive impairment: A systematic review and network meta-analysis of randomized controlled trials133
Western diet as a trigger of Alzheimer’s disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration127
Past, present and future of therapeutic strategies against amyloid-β peptides in Alzheimer’s disease: a systematic review127
Nrf2: a dark horse in Alzheimer's disease treatment123
Effects of monoclonal antibodies against amyloid-β on clinical and biomarker outcomes and adverse event risks: A systematic review and meta-analysis of phase III RCTs in Alzheimer’s disease116
Stress and telomere shortening: Insights from cellular mechanisms115
The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: From antioxidant to epigenetic therapy115
Healthful aging mediated by inhibition of oxidative stress114
ACE2 imbalance as a key player for the poor outcomes in COVID-19 patients with age-related comorbidities – Role of gut microbiota dysbiosis111
Hypoxia and brain aging: Neurodegeneration or neuroprotection?110
The association of objectively measured physical activity and sedentary behavior with skeletal muscle strength and muscle power in older adults: A systematic review and meta-analysis106
The involvement of NLRP3 inflammasome in the treatment of Alzheimer’s disease105
Prevention of dementia in an ageing world: Evidence and biological rationale103
Branched chain amino acids, aging and age-related health102
Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases100
Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities98
Autophagy and the hallmarks of aging97
Wnt signaling pathway in aging-related tissue fibrosis and therapies96
Circadian and sleep dysfunction in Alzheimer’s disease95
Crosstalk between obesity, diabetes, and alzheimer’s disease: Introducing quercetin as an effective triple herbal medicine95
Biomarkers shared by frailty and sarcopenia in older adults: A systematic review and meta-analysis95
Autophagy in Alzheimer’s disease pathogenesis: Therapeutic potential and future perspectives95
miR-21 and miR-146a: The microRNAs of inflammaging and age-related diseases93
Novel target for treating Alzheimer’s Diseases: Crosstalk between the Nrf2 pathway and autophagy89
Cross-sectional and longitudinal associations between adherence to Mediterranean diet with physical performance and cognitive function in older adults: A systematic review and meta-analysis89
Neuronal excitation/inhibition imbalance: core element of a translational perspective on Alzheimer pathophysiology87
Mitochondrial dysfunction, oxidative stress, neuroinflammation, and metabolic alterations in the progression of Alzheimer’s disease: A meta-analysis of in vivo magnetic resonance spectroscopy studies86
Systematic review and analysis of human proteomics aging studies unveils a novel proteomic aging clock and identifies key processes that change with age83
Mitochondria in Ovarian Aging and Reproductive Longevity80
Single-cell analyses of aging, inflammation and senescence80
Mitochondria: Their relevance during oocyte ageing79
Inflammatory pathways in Alzheimer’s disease mediated by gut microbiota77
Updated systematic review and meta-analysis on diagnostic issues and the prognostic impact of myosteatosis: A new paradigm beyond sarcopenia77
Autophagy in the diabetic heart: A potential pharmacotherapeutic target in diabetic cardiomyopathy77
Education and age-related decline in cognitive performance: Systematic review and meta-analysis of longitudinal cohort studies76
Targeting immune dysfunction in aging76
Biological and environmental predictors of heterogeneity in neurocognitive ageing74
Omics sciences for systems biology in Alzheimer’s disease: State-of-the-art of the evidence73
The road ahead for health and lifespan interventions72
Prevalence of multidimensional frailty and pre-frailty in older people in different settings: A systematic review and meta-analysis69
COVID-19: risk accumulation among biologically and socially vulnerable older populations68
The role of Nrf2 in neural stem/progenitors cells: From maintaining stemness and self-renewal to promoting differentiation capability and facilitating therapeutic application in neurodegenerative dise68
Inter and Intracellular mitochondrial trafficking in health and disease68
Benefits and harms of exercise therapy in people with multimorbidity: A systematic review and meta-analysis of randomised controlled trials67
Home-based exercise programmes improve physical fitness of healthy older adults: A PRISMA-compliant systematic review and meta-analysis with relevance for COVID-1964
The hoverfly and the wasp: A critique of the hallmarks of aging as a paradigm64
The role of nutrition in inflammaging64
The emerging role of exosomes in Alzheimer’s disease63
Mitophagy Receptors and Mediators: Therapeutic Targets in the Management of Cardiovascular Ageing63
The ageing kidney: Molecular mechanisms and clinical implications63
Re-emphasizing early Alzheimer’s disease pathology starting in select entorhinal neurons, with a special focus on mitophagy61
Inflammaging, hormesis and the rationale for anti-aging strategies61
Modifiable lifestyle factors and cognitive reserve: A systematic review of current evidence61
Optimal dose and type of exercise to improve cognitive function in older adults: A systematic review and bayesian model-based network meta-analysis of RCTs61
DNA methylation-based age clocks: From age prediction to age reversion60
Mesenchymal stem cell-derived extracellular vesicle-based therapies protect against coupled degeneration of the central nervous and vascular systems in stroke60
Ageing of the gut microbiome: Potential influences on immune senescence and inflammageing60
Towards an understanding of the physical activity-BDNF-cognition triumvirate: A review of associations and dosage60
Is personality associated with dementia risk? A meta-analytic investigation59
Obesity and aging: Molecular mechanisms and therapeutic approaches59
Comparative effectiveness of three exercise types to treat clinical depression in older adults: A systematic review and network meta-analysis of randomised controlled trials59
Cellular senescence in knee osteoarthritis: molecular mechanisms and therapeutic implications58
Elastic fibers during aging and disease56
Reactive astrocytes: The nexus of pathological and clinical hallmarks of Alzheimer’s disease56
Biomarkers used in Alzheimer’s disease diagnosis, treatment, and prevention56
Dysbiosis, malnutrition and enhanced gut-lung axis contribute to age-related respiratory diseases55
Promising biomarkers of human aging: In search of a multi-omics panel to understand the aging process from a multidimensional perspective54
The accelerated aging phenotype: The role of race and social determinants of health on aging54
From DNA damage to mutations: All roads lead to aging54
Nutrition and the ageing brain: Moving towards clinical applications53
Effects of exercise interventions on the functional status of acutely hospitalised older adults: A systematic review and meta-analysis53
Olfactory dysfunction in aging and neurodegenerative diseases53
Deregulated mitochondrial microRNAs in Alzheimer's disease: Focus on synapse and mitochondria53
Calorie restriction for enhanced longevity: The role of novel dietary strategies in the present obesogenic environment53
Epigenetic regulation of melanogenesis53
The geroscience agenda: Toxic stress, hormetic stress, and the rate of aging52
Deterioration of nuclear morphology and architecture: A hallmark of senescence and aging51
Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders51
Center of pressure displacement characteristics differentiate fall risk in older people: A systematic review with meta-analysis51
The role of the immune system in Alzheimer’s disease51
A common signature of cellular senescence; does it exist?50
Short-chain fatty acid metabolism and multiple effects on cardiovascular diseases50
Medium Chain Triglycerides induce mild ketosis and may improve cognition in Alzheimer’s disease. A systematic review and meta-analysis of human studies49
COVID-19 mortality as a fingerprint of biological age49
The hyperfunction theory: An emerging paradigm for the biology of aging49
Is living alone a risk factor of frailty? A systematic review and meta-analysis49
Targeting autophagy in osteoporosis: From pathophysiology to potential therapy48
Frailty prevalence and impact on outcomes in patients with atrial fibrillation: A systematic review and meta-analysis of 1,187,000 patients48
Motoric cognitive risk syndrome: Integration of two early harbingers of dementia in older adults48
The neurobiology of non-coding RNAs and Alzheimer’s disease pathogenesis: Pathways, mechanisms and translational opportunities47
The dialogue between the ubiquitin-proteasome system and autophagy: Implications in ageing47
Exercise interventions in Alzheimer’s disease: A systematic review and meta-analysis of randomized controlled trials46
Perivascular adipose tissue in age-related vascular disease45
New insights into the interplay between miRNAs and autophagy in the aging of intervertebral discs45
The protective role of exercise against age-related neurodegeneration44
Monoamine oxidases in age-associated diseases: New perspectives for old enzymes44
Telomere transcription in ageing44
Epigenetic clock: A promising biomarker and practical tool in aging43
Hormesis and Ginkgo biloba (GB): Numerous biological effects of GB are mediated via hormesis43
Brain lipid peroxidation and alzheimer disease: Synergy between the Butterfield and Mattson laboratories43
Diabetes mellitus and hearing loss: A review42
The role of serotonin within the microbiota-gut-brain axis in the development of Alzheimer’s disease: A narrative review42
Exploring ER stress response in cellular aging and neuroinflammation in Alzheimer's disease42
Attenuation of 7-ketocholesterol- and 7β-hydroxycholesterol-induced oxiapoptophagy by nutrients, synthetic molecules and oils: Potential for the prevention of age-related diseases42
Associations between nutrition and the incidence of depression in middle-aged and older adults: A systematic review and meta-analysis of prospective observational population-based studies42
GDF15, an emerging key player in human aging41
Nutritional domains in frailty tools: Working towards an operational definition of nutritional frailty41
Curcumin nanoformulations to combat aging-related diseases41
Fibroageing: An ageing pathological feature driven by dysregulated extracellular matrix-cell mechanobiology41
Efficacy of lifestyle and psychosocial interventions in reducing cognitive decline in older people: Systematic review41
Retinal biomarkers in Alzheimer’s disease and mild cognitive impairment: A systematic review and meta-analysis41
Social hallmarks of aging: Suggestions for geroscience research41
Pleiotropic effects of alpha-ketoglutarate as a potential anti-ageing agent40
Lamin A involvement in ageing processes40
Potential roles of gut microbiota and microbial metabolites in Parkinson’s disease40
Time-restricted feeding (TRF) for prevention of age-related vascular cognitive impairment and dementia40
Post-translational modifications: Regulators of neurodegenerative proteinopathies40
Living alone and risk of dementia: A systematic review and meta-analysis40
Effects of exergames and cognitive-motor dual-task training on cognitive, physical and dual-task functions in cognitively healthy older adults: An overview40
Iron homeostasis and organismal aging39
Frailty is highly prevalent in specific cardiovascular diseases and females, but significantly worsens prognosis in all affected patients: A systematic review39
Role of indoleamine 2,3-dioxygenase 1 (IDO1) and kynurenine pathway in the regulation of the aging process39
Targeting senescent cells to attenuate cardiovascular disease progression39
Neurogenesis in aging and age-related neurodegenerative diseases39
Osteocytes in bone aging: Advances, challenges, and future perspectives38
Roles of the actin cytoskeleton in aging and age-associated diseases38
Glial cells in Alzheimer’s disease: From neuropathological changes to therapeutic implications38
The complex associations between late life depression, fear of falling and risk of falls. A systematic review and meta-analysis38
Mechanosensing dysregulation in the fibroblast: A hallmark of the aging heart38
Oxidized nicotinamide adenine dinucleotide-dependent mitochondrial deacetylase sirtuin-3 as a potential therapeutic target of Parkinson’s disease37
Cerebral blood flow in mild cognitive impairment and Alzheimer’s disease: A systematic review and meta-analysis37
The potential roles of deubiquitinating enzymes in brain diseases37
Lipocalin 2 as a link between ageing, risk factor conditions and age-related brain diseases37
Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging36
Effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on ageing: Molecular mechanisms35
Sarcopenia definition: Does it really matter? Implications for resistance training35
The emerging role of skeletal muscle mitochondrial dynamics in exercise and ageing35
Astrocyte mitochondria: Central players and potential therapeutic targets for neurodegenerative diseases and injury35
Interactions between glial cells and the blood-brain barrier and their role in Alzheimer's disease35
Age-related changes in muscle architecture and metabolism in humans: The likely contribution of physical inactivity to age-related functional decline35
Toward noninvasive brain stimulation 2.0 in Alzheimer’s disease35
Unsupervised home-based resistance training for community-dwelling older adults: A systematic review and meta-analysis of randomized controlled trials35
Recent advances in the field of caloric restriction mimetics and anti-aging molecules35
DNA damage repair response in mesenchymal stromal cells: From cellular senescence and aging to apoptosis and differentiation ability34
Does eNOS derived nitric oxide protect the young from severe COVID-19 complications?34
Iron homeostasis in arthropathies: From pathogenesis to therapeutic potential34
The Role of Rapamycin in Healthspan Extension via the Delay of Organ Aging34
Efficacy of non-invasive brain stimulation on global cognition and neuropsychiatric symptoms in Alzheimer’s disease and mild cognitive impairment: A meta-analysis and systematic review34
Feed-forward regulation between cellular senescence and immunosuppression promotes the aging process and age-related diseases33
Noncoding RNAs in age-related cardiovascular diseases33
Aging adipose: Depot location dictates age-associated expansion and dysfunction33
Risk factors for falls in older people with cognitive impairment living in the community: Systematic review and meta-analysis33
Cortisol hypersecretion and the risk of Alzheimer’s disease: A systematic review and meta-analysis33
The emerging role of T follicular helper (TFH) cells in aging: Influence on the immune frailty33
Prevalence of unwillingness and uncertainty to vaccinate against COVID-19 in older people: A systematic review and meta-analysis32
Blood fatty acids in Alzheimer’s disease and mild cognitive impairment: A meta-analysis and systematic review32
Does oxidative stress shorten telomeres in vivo? A meta-analysis32
Emerging pathogenic role of peripheral blood factors following BBB disruption in neurodegenerative disease32
Artificial intelligence in brain MRI analysis of Alzheimer’s disease over the past 12 years: A systematic review32
Fatigue and the prediction of negative health outcomes: A systematic review with meta-analysis32
Therapy for Alzheimer’s disease: Missing targets and functional markers?32
Senescence in tissue samples of humans with age-related diseases: A systematic review32
Identification of altered exosomal microRNAs and mRNAs in Alzheimer's disease32
Fostering healthy aging: The interdependency of infections, immunity and frailty32
The potential role of melatonin in retarding intervertebral disc ageing and degeneration: A systematic review31
How age relates to spatial navigation performance: Functional and methodological considerations31
Transcranial magnetic stimulation (TMS) for geriatric depression31
Functional roles of circular RNAs in Alzheimer’s disease31
Fight to the bitter end: DNA repair and aging31
Exosome: A novel neurotransmission modulator or non-canonical neurotransmitter?31
Role of Nrf2 in aging, Alzheimer’s and other neurodegenerative diseases31
Thymus involution sets the clock of the aging T-cell landscape: Implications for declined immunity and tissue repair30
The emerging role of the sympathetic nervous system in skeletal muscle motor innervation and sarcopenia30
Pleiotropic effects of polyphenols on glucose and lipid metabolism: Focus on clinical trials30
From beta amyloid to altered proteostasis in Alzheimer’s disease30
A systematic review of the impacts of intergenerational engagement on older adults’ cognitive, social, and health outcomes30
Structure-functional implications of longevity protein p66Shc in health and disease30
Hippuric acid: Could became a barometer for frailty and geriatric syndromes?29
Roles of clock genes in the pathogenesis of Parkinson's disease29
Targeting metabolic pathways for extension of lifespan and healthspan across multiple species29
How good is the evidence that cellular senescence causes skin ageing?29
Heart rate variability in relation to cognition and behavior in neurodegenerative diseases: A systematic review and meta-analysis29
Stepping impairment and falls in older adults: A systematic review and meta-analysis of volitional and reactive step tests29
Formaldehyde toxicity in age-related neurological dementia28
Endosomal dysfunction impacts extracellular vesicle release: Central role in Aβ pathology28
An elusive consensus definition of sarcopenia impedes research and clinical treatment: A narrative review28
Defining and assessing intrinsic capacity in older people: A systematic review and a proposed scoring system28
Salivary biomarkers of neurodegenerative and demyelinating diseases and biosensors for their detection28
Emerging potential of cannabidiol in reversing proteinopathies28
Reducing neuroinflammation via therapeutic compounds and lifestyle to prevent or delay progression of Parkinson’s disease28
Senescent cells as promising targets to tackle age-related diseases28
Proteomics as a reliable approach for discovery of blood-based Alzheimer’s disease biomarkers: A systematic review and meta-analysis27
Exploring the multifunctional role of melatonin in regulating autophagy and sleep to mitigate Alzheimer’s disease neuropathology27
PINK1/Parkin-mediated mitophagy in neurodegenerative diseases27
Aging-suppressor Klotho: Prospects in diagnostics and therapeutics26
Dissecting primary and secondary senescence to enable new senotherapeutic strategies26
Diagnostic performance of digital cognitive tests for the identification of MCI and dementia: A systematic review26
β-amyloid: The known unknowns26
Region-specific vulnerability in neurodegeneration: lessons from normal ageing26
The multi-faceted impact of methamphetamine on Alzheimer’s disease: From a triggering role to a possible therapeutic use26
Melatonin: A novel candidate for the treatment of osteoarthritis26
Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer’s disease: Past, present and future26
Ubiquitin biology in neurodegenerative disorders: From impairment to therapeutic strategies26
Effects of influenza vaccination on the risk of cardiovascular and respiratory diseases and all-cause mortality25
Mechanisms linking mitochondrial mechanotransduction and chondrocyte biology in the pathogenesis of osteoarthritis25
Role of microRNAs in neurodegeneration induced by environmental neurotoxicants and aging25
Risk for Alzheimer’s disease: A review of long-term episodic memory encoding and retrieval fMRI studies25
Female specific risk factors for the development of Alzheimer’s disease neuropathology and cognitive impairment: Call for a precision medicine approach25
Systemic manifestation and contribution of peripheral tissues to Huntington’s disease pathogenesis25
Estimates of malnutrition and risk of malnutrition among the elderly (≥60 years) in India: A systematic review and meta-analysis25
Roles and mechanisms of MFG-E8 in vascular aging-related diseases25
Research progress in the use of mesenchymal stem cells and their derived exosomes in the treatment of osteoarthritis25
Environmental factors and risks of cognitive impairment and dementia: A systematic review and meta-analysis24
Transposable elements in brain health and disease24
Prepulse inhibition of the acoustic startle reflex and P50 gating in aging and alzheimer’s disease24
Multi-omics research in sarcopenia: Current progress and future prospects24
Socioeconomic position and healthy ageing: A systematic review of cross-sectional and longitudinal studies24
Assessing the rate of aging to monitor aging itself24
Altered endocytosis in cellular senescence24
Anthocyanin as a therapeutic in Alzheimer’s disease: A systematic review of preclinical evidences24
Frailty biomarkers under the perspective of geroscience: A narrative review24
MRI-based biomarkers of accelerated aging and dementia risk in midlife: how close are we?24
Underrepresentation of older adults in clinical trials on COVID-19 vaccines: A systematic review24
Searching for the link between inflammaging and sarcopenia24
The effect of Tai Chi in elderly individuals with sarcopenia and frailty: A systematic review and meta-analysis of randomized controlled trials23
MicroRNAs in the regulation of autophagy and their possible use in age-related macular degeneration therapy23
Immunometabolic responses according to physical fitness status and lifelong exercise during aging: New roads for exercise immunology23
The neuromicrobiology of Parkinson’s disease: A unifying theory23
Behavioral and Social Research to Accelerate the Geroscience Translation Agenda23
Associations of Omega-3 fatty acids with brain morphology and volume in cognitively healthy older adults: A narrative review23
Socially assistive robots for people with dementia: Systematic review and meta-analysis of feasibility, acceptability and the effect on cognition, neuropsychiatric symptoms and quality of life23
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