Ageing Research Reviews

Papers
(The H4-Index of Ageing Research Reviews is 80. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)
ArticleCitations
Start the engine of neuroregeneration: A mechanistic and strategic overview of direct astrocyte-to-neuron reprogramming352
Editorial Board327
Editorial Board320
Roles of hypoxia-inducible factor-prolyl hydroxylases in aging and disease316
cGAS-STING-driven inflammaging cascade in aging-related retinal diseases: From pathological mechanism to therapeutic potentials299
Type 2 diabetes mellitus augments Parkinson’s disease risk or the other way around: Facts, challenges and future possibilities264
Dysfunction of norepinephrine and its metabolites in Alzheimer's dementia – A review with meta-analysis241
Discovery of a new hereditary RECQ helicase disorder RECON syndrome positions the replication stress response and genome homeostasis as centrally important processes in aging and age-related disease220
Editor’s Note to “Biological constraint, evolutionary spandrels and antagonistic pleiotropy”210
Reevaluating principal component analysis in geroscience: A call for nonlinear approaches in AI-based evaluations202
The unique neuropathological vulnerability of the human brain to aging194
CC chemokines family in fibrosis and aging: From mechanisms to therapy191
The past, present, and future of adipose tissue browning and aging: A review combined with bibliometrics and bioinformatics of 2527 documents published over the past four decades186
Guardians of homeostasis: Natural products target metabolic reprogramming in Alzheimer’s disease182
Intrinsic capacity evolution during aging in mouse and fish: Longitudinal perspectives from a narrative review179
Targeting tau-mitochondrial crosstalk in Alzheimer’s disease with an Integrative multi-omics and artificial intelligence driven tools for the development of disease-modifying therapeutics178
Thioredoxin-1 inhibits the activation of IRE1 by targeting Hsp90/p-Cdc37 chaperone complex in Parkinson disease177
Medication reviews in hospitalised patients for reduced hospital readmission and mortality. Systematic review, meta-analysis and meta-regression of RCTs172
Histopathological and ultrastructural changes in different cell types during ischemic and hemorrhagic stroke164
Effectiveness of virtual reality interventions on quality of life, cognitive function and physical function in older people with Alzheimer's disease: A systematic review161
Unravelling the brain resilience following stroke: From injury to rewiring of the brain through pathway activation, drug targets, and therapeutic interventions157
Ergothioneine and exercise: A match made in (cognitive) heaven?151
HIV infection is associated with accelerated epigenetic ageing: A systematic review148
Cerebral glymphatic system: Structure, regulation, ageing, and mechanisms of encephalopathy145
Unraveling the protein post-translational modification landscape: Neuroinflammation and neuronal death after stroke145
Sarcobesity: New paradigms for healthy aging related to taurine supplementation, gut microbiota and exercise145
Can dementia risk be reduced by following the American Heart Association's Life's Simple 7? A systematic review and dose-response meta-analysis144
From ageing clocks to organ networks: Biological age-driven organ asynchrony and inter-organ interactions shaping mortality risk140
The m⁶A epitranscriptome: A regulatory nexus linking cellular senescence and oncogenesis138
Efficacy of technology-based cognitive and exercise interventions for mild cognitive impairment: A systematic review, network meta-analysis, and meta-regression of randomized controlled trials138
Microglia and gut microbiota: A double-edged sword in Alzheimer's disease136
Adenosine metabolism and receptors in aging of the skin, musculoskeletal, immune and cardiovascular systems135
Repetitive transcranial magnetic stimulation combined with cognitive training for cognitive function and activities of daily living in patients with post-stroke cognitive impairment: A systematic revi134
Does drug repurposing bridge the gaps in management of Parkinson’s disease? Unravelling the facts and fallacies133
Glymphatic dysfunction in Parkinson's disease: Aging-associated impairments, imaging biomarkers, and therapeutic strategies130
Advances in Alzheimer's therapy: Exploring neuropathological mechanisms to revolutionize the future therapeutic landscape128
Organelle interactome disruption: The systemic pathological mechanisms and therapeutic prospects of mitochondria-lysosome-ER crosstalk in Alzheimer's disease122
Advances in clinical application of lipidomics in healthy ageing and healthy longevity medicine121
Prevalence and health outcomes of polypharmacy and hyperpolypharmacy in older adults with frailty: A systematic review and meta-analysis120
The functions of IRE1α in neurodegenerative diseases: Beyond ER stress120
Vascular cognitive impairment – Past, present, and future challenges119
Multifaceted cell death in atherosclerosis: Mechanisms, pathological impact, and therapeutic targeting118
Global, regional, and national burden of spinal cord injury from 1990 to 2021 and projections for 2050: A systematic analysis for the Global Burden of Disease 2021 study118
Protein and peptide based nanotherapeutics for the management of Alzheimer’s disease: Current insights and future directions117
Insulin resistance as a mediator of physical activity's effects on beta-amyloid accumulation and tau phosphorylation: A scoping review117
Biomarkers associated with cognitive impairment in post-traumatic stress disorder: A systematic review of current evidence116
The several ways to authentically cure Alzheimer’s dementia115
Identification of exosomal biomarkers and its optimal isolation and detection method for the diagnosis of Parkinson's disease: A systematic review and meta-analysis115
The link between metabolic syndrome and Alzheimer disease: A mutual relationship and long rigorous investigation109
Triaging between post-translational modification of cell cycle regulators and their therapeutics in neurodegenerative diseases107
Characterization of the logopenic variant of Primary Progressive Aphasia: A systematic review and meta-analysis106
Three-dimensional human brain organoids: A next-generation model to decode Alzheimer’s disease105
Unravelling the miscellaneous effects of exercise interventions on activities of daily living in frail older adults: A systematic review and meta-analysis105
HMGB1, an evolving pleiotropic protein critical for cellular and tissue homeostasis: Role in aging and age-related diseases103
Associations of olfactory function with brain structural and functional outcomes. A systematic review103
Exercise and the hallmarks of cardiovascular aging101
Research progress in Alzheimer's disease and bone-brain axis101
Quality and recommendations of guidelines for multimorbidity and polypharmacy in older adults: A systematic review101
Sensory nerve regulation of bone homeostasis: Emerging therapeutic opportunities for bone-related diseases101
Mitochondria-associated endoplasmic reticulum membranes as aging-sensitive signaling hubs in degenerative musculoskeletal diseases100
Overview of pro-inflammatory and pro-survival components in neuroinflammatory signalling and neurodegeneration97
Cytosolic DNA sensor IFI16 proteins: Potential molecular integrators of interactions among the aging hallmarks97
Transcranial direct current stimulation combined with motor training for motor symptoms in Parkinson's disease: A systematic review and meta-analysis97
The role of the gut microbiota in neuropsychiatric disorders and therapy95
Adherence to the Mediterranean diet and risk of frailty and pre-frailty in elderly adults: A systematic review and dose-response meta-analysis with GRADE assessment93
Interventions to prevent and treat delirium: An umbrella review of randomized controlled trials93
Trained immunity in the treatment for haematological malignancy92
Cognitive resilience in Alzheimer’s disease: Mechanism and potential clinical intervention92
Melatonin: Potential avenue for treating iron overload disorders91
Neuroprotection by agmatine: Possible involvement of the gut microbiome?91
Involvement of regulated cell deaths in aging and age-related pathologies91
The role of the PLA2G6 gene in neurodegenerative diseases89
Artificial intelligence for fall detection in older adults: A comprehensive survey of machine learning, deep learning approaches, and future directions88
The effectiveness of dance movement interventions for older adults with mild cognitive impairment, Alzheimer’s disease, and dementia: A systematic scoping review and meta-analysis88
On the wake of metformin: Do anti-diabetic SGLT2 inhibitors exert anti-aging effects?87
Blood-based biomarkers for Alzheimer's disease: Advances in early detection and monitoring of age-related neurodegeneration85
New era of artificial intelligence and machine learning-based detection, diagnosis, and therapeutics in Parkinson’s disease85
Betaine and aging: A narrative review of findings, possible mechanisms, research perspectives, and practical recommendations85
Advances of artificial intelligence in predicting frailty using real-world data: A scoping review84
Targeting aging with urolithin A in humans: A systematic review84
Bridging neurotrophic factors and bioactive peptides to Alzheimer's disease80
A Multimodal Meta-Analytical Evidence of Functional and Structural Brain Abnormalities Across Alzheimer's Disease Spectrum80
Hallmarks of aging: A user’s guide for comparative biologists80
The mitochondrial integrated stress response: A novel approach to anti-aging and pro-longevity80
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