Ageing Research Reviews

Papers
(The H4-Index of Ageing Research Reviews is 79. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)
ArticleCitations
Start the engine of neuroregeneration: A mechanistic and strategic overview of direct astrocyte-to-neuron reprogramming683
Editorial Board311
Editor’s Note to “Biological constraint, evolutionary spandrels and antagonistic pleiotropy”280
The functions of IRE1α in neurodegenerative diseases: Beyond ER stress280
Cerebral glymphatic system: Structure, regulation, ageing, and mechanisms of encephalopathy244
HIV infection is associated with accelerated epigenetic ageing: A systematic review238
Advances in Alzheimer's therapy: Exploring neuropathological mechanisms to revolutionize the future therapeutic landscape226
Editorial Board217
Prevalence and health outcomes of polypharmacy and hyperpolypharmacy in older adults with frailty: A systematic review and meta-analysis210
Can dementia risk be reduced by following the American Heart Association's Life's Simple 7? A systematic review and dose-response meta-analysis193
Roles of hypoxia-inducible factor-prolyl hydroxylases in aging and disease193
cGAS-STING-driven inflammaging cascade in aging-related retinal diseases: From pathological mechanism to therapeutic potentials185
Type 2 diabetes mellitus augments Parkinson’s disease risk or the other way around: Facts, challenges and future possibilities180
The m⁶A epitranscriptome: A regulatory nexus linking cellular senescence and oncogenesis174
From ageing clocks to organ networks: Biological age-driven organ asynchrony and inter-organ interactions shaping mortality risk169
The past, present, and future of adipose tissue browning and aging: A review combined with bibliometrics and bioinformatics of 2527 documents published over the past four decades161
Dysfunction of norepinephrine and its metabolites in Alzheimer's dementia – A review with meta-analysis159
Efficacy of technology-based cognitive and exercise interventions for mild cognitive impairment: A systematic review, network meta-analysis, and meta-regression of randomized controlled trials153
Adenosine metabolism and receptors in aging of the skin, musculoskeletal, immune and cardiovascular systems148
Sarcobesity: New paradigms for healthy aging related to taurine supplementation, gut microbiota and exercise140
Reevaluating principal component analysis in geroscience: A call for nonlinear approaches in AI-based evaluations139
Histopathological and ultrastructural changes in different cell types during ischemic and hemorrhagic stroke138
CC chemokines family in fibrosis and aging: From mechanisms to therapy138
The unique neuropathological vulnerability of the human brain to aging138
Vascular cognitive impairment – Past, present, and future challenges136
Advances in clinical application of lipidomics in healthy ageing and healthy longevity medicine134
Does drug repurposing bridge the gaps in management of Parkinson’s disease? Unravelling the facts and fallacies133
Ergothioneine and exercise: A match made in (cognitive) heaven?128
Discovery of a new hereditary RECQ helicase disorder RECON syndrome positions the replication stress response and genome homeostasis as centrally important processes in aging and age-related disease127
Microglia and gut microbiota: A double-edged sword in Alzheimer's disease125
Guardians of homeostasis: Natural products target metabolic reprogramming in Alzheimer’s disease125
Effectiveness of virtual reality interventions on quality of life, cognitive function and physical function in older people with Alzheimer's disease: A systematic review124
Medication reviews in hospitalised patients for reduced hospital readmission and mortality. Systematic review, meta-analysis and meta-regression of RCTs123
Repetitive transcranial magnetic stimulation combined with cognitive training for cognitive function and activities of daily living in patients with post-stroke cognitive impairment: A systematic revi122
Unravelling the brain resilience following stroke: From injury to rewiring of the brain through pathway activation, drug targets, and therapeutic interventions121
Glymphatic dysfunction in Parkinson's disease: Aging-associated impairments, imaging biomarkers, and therapeutic strategies120
Unraveling the protein post-translational modification landscape: Neuroinflammation and neuronal death after stroke118
Global, regional, and national burden of spinal cord injury from 1990 to 2021 and projections for 2050: A systematic analysis for the Global Burden of Disease 2021 study117
Thioredoxin-1 inhibits the activation of IRE1 by targeting Hsp90/p-Cdc37 chaperone complex in Parkinson disease115
Melatonin: Potential avenue for treating iron overload disorders114
Artificial intelligence in brain MRI analysis of Alzheimer’s disease over the past 12 years: A systematic review114
Quality and recommendations of guidelines for multimorbidity and polypharmacy in older adults: A systematic review112
Unravelling the miscellaneous effects of exercise interventions on activities of daily living in frail older adults: A systematic review and meta-analysis112
HMGB1, an evolving pleiotropic protein critical for cellular and tissue homeostasis: Role in aging and age-related diseases109
Characterization of the logopenic variant of Primary Progressive Aphasia: A systematic review and meta-analysis108
Associations of olfactory function with brain structural and functional outcomes. A systematic review108
Role of diet and exercise in aging, Alzheimer’s disease, and other chronic diseases107
Adherence to the Mediterranean diet and risk of frailty and pre-frailty in elderly adults: A systematic review and dose-response meta-analysis with GRADE assessment104
Betaine and aging: A narrative review of findings, possible mechanisms, research perspectives, and practical recommendations104
Neuroprotection by agmatine: Possible involvement of the gut microbiome?103
New era of artificial intelligence and machine learning-based detection, diagnosis, and therapeutics in Parkinson’s disease102
Bridging neurotrophic factors and bioactive peptides to Alzheimer's disease101
Cytosolic DNA sensor IFI16 proteins: Potential molecular integrators of interactions among the aging hallmarks99
The several ways to authentically cure Alzheimer’s dementia96
Biomarkers associated with cognitive impairment in post-traumatic stress disorder: A systematic review of current evidence95
Protein and peptide based nanotherapeutics for the management of Alzheimer’s disease: Current insights and future directions95
Transcranial direct current stimulation combined with motor training for motor symptoms in Parkinson's disease: A systematic review and meta-analysis94
On the wake of metformin: Do anti-diabetic SGLT2 inhibitors exert anti-aging effects?93
Triaging between post-translational modification of cell cycle regulators and their therapeutics in neurodegenerative diseases93
Overview of pro-inflammatory and pro-survival components in neuroinflammatory signalling and neurodegeneration93
Advances of artificial intelligence in predicting frailty using real-world data: A scoping review93
Artificial intelligence for fall detection in older adults: A comprehensive survey of machine learning, deep learning approaches, and future directions92
Blood-based biomarkers for Alzheimer's disease: Advances in early detection and monitoring of age-related neurodegeneration91
The role of the PLA2G6 gene in neurodegenerative diseases90
Three-dimensional human brain organoids: A next-generation model to decode Alzheimer’s disease90
The role of the gut microbiota in neuropsychiatric disorders and therapy89
Insulin resistance as a mediator of physical activity's effects on beta-amyloid accumulation and tau phosphorylation: A scoping review89
The link between metabolic syndrome and Alzheimer disease: A mutual relationship and long rigorous investigation88
The effectiveness of dance movement interventions for older adults with mild cognitive impairment, Alzheimer’s disease, and dementia: A systematic scoping review and meta-analysis88
Hallmarks of aging: A user’s guide for comparative biologists85
The mitochondrial integrated stress response: A novel approach to anti-aging and pro-longevity84
Exercise and the hallmarks of cardiovascular aging84
Sensory nerve regulation of bone homeostasis: Emerging therapeutic opportunities for bone-related diseases83
Involvement of regulated cell deaths in aging and age-related pathologies83
Potential convergence of olfactory dysfunction in Parkinson’s disease and COVID-19: The role of neuroinflammation82
Searching for the link between inflammaging and sarcopenia81
Cognitive resilience in Alzheimer’s disease: Mechanism and potential clinical intervention80
Identification of exosomal biomarkers and its optimal isolation and detection method for the diagnosis of Parkinson's disease: A systematic review and meta-analysis80
Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseases79
A Multimodal Meta-Analytical Evidence of Functional and Structural Brain Abnormalities Across Alzheimer's Disease Spectrum79
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