Current Topics in Medicinal Chemistry

Article	Citations
Bioactive Compounds Effective Against Type 2 Diabetes Mellitus: A Systematic Review	99
Recent Progress in 1H-1,2,3-triazoles as Potential Antifungal Agents	48
Emerging Proof of Protein Misfolding and Interactions in Multifactorial Alzheimer's Disease	47
Nanotechnology, A Tool for Diagnostics and Treatment of Cancer	43
A Review on Natural Sources Derived Protein Nanoparticles as Anticancer Agents	42
Coumarin-1,2,3-triazole Hybrid Molecules: An Emerging Scaffold for Combating Drug Resistance	38
An Overview of Privileged Scaffold: Quinolines and Isoquinolines in Medicinal Chemistry as Anticancer Agents	35
Eugenol as a Potential Drug Candidate: A Review	34
An Updated Review on SARS-CoV-2 Main Proteinase (MPro): Protein Structure and Small-Molecule Inhibitors	33
1,2,4-Triazole: A Privileged Scaffold for the Development of Potent Antifungal Agents - A Brief Review	33
An Update on Staphylococcus aureus NorA Efflux Pump Inhibitors	33
The Effect of Recombinant Human Interferon Alpha Nasal Drops to Prevent COVID-19 Pneumonia for Medical Staff in an Epidemic Area	33
Potential Inhibitors of Protein Tyrosine Phosphatase (PTP1B) Enzyme: Promising Target for Type-II Diabetes Mellitus	32
Garlic (Allium sativum L.): Its Chemistry, Nutritional Composition, Toxicity, and Anticancer Properties	30
The Antibacterial Activity of 1,2,3-triazole- and 1,2,4-Triazole-containing Hybrids against Staphylococcus aureus: An Updated Review (2020- Present)	29
Berberine: A Promising Natural Isoquinoline Alkaloid for the Development of Hypolipidemic Drugs	29
Nociceptin/Orphanin FQ Peptide Receptor-Related Ligands as Novel Analgesics	29
Shape-based Machine Learning Models for the Potential Novel COVID-19 Protease Inhibitors Assisted by Molecular Dynamics Simulation	29
Peptide Receptor Radionuclide Therapy: Looking Back, Looking Forward	28
“Big Three” Infectious Diseases: Tuberculosis, Malaria and HIV/AIDS	28
Resveratrol and Colorectal Cancer: A Molecular Approach to Clinical Researches	27
Natural Products as Sources of Multitarget Compounds: Advances in the Development of Ferulic Acid as Multitarget Therapeutic	26
The Antibacterial Activity of Natural-derived Flavonoids	26
Docking Paradigm in Drug Design	26
Chemical and Biological Evaluation of Thiosemicarbazone-Bearing Heterocyclic Metal Complexes	25

Cruzain and Rhodesain Inhibitors: Last Decade of Advances in Seeking for New Compounds Against American and African Trypanosomiases	25
Resveratrol in Cancer Therapy: From Stimulation of Genomic Stability to Adjuvant Cancer Therapy: A Comprehensive Review	24
Exploring the Potential Inhibition of Candidate Drug Molecules for Clinical Investigation Based on their Docking or Crystallographic Analyses against M. tuberculosis Enzyme Targets	22
Recent Advances of α-Glucosidase Inhibitors: A Comprehensive Review	22
Phenolic Acids - Versatile Natural Moiety with Numerous Biological Applications	21
Indole Alkaloids, Synthetic Dimers and Hybrids with Potential In Vivo Anticancer Activity	21
Tuberculosis: An Update on Pathophysiology, Molecular Mechanisms of Drug Resistance, Newer Anti-TB Drugs, Treatment Regimens and Host- Directed Therapies	21
New Pharmacological Targets for the Treatment of Schizophrenia: A Literature Review	20
Perspectives on Fragment-based Drug Discovery: A Strategy Applicable to Diverse Targets	20
Bergenin - A Biologically Active Scaffold: Nanotechnological Perspectives	20
Thiazole-based Chalcone Derivatives as Potential Anti-inflammatory Agents: Biological Evaluation and Molecular Modelling	20
Interleukin-1 in Coronary Artery Disease	20
Investigation of the Relationship among Cortisol, Pro-inflammatory Cytokines, and the Degradation of Tryptophan into Kynurenine in Patients with Major Depression and Suicidal Behavior	19
Tumor-associated Macrophages (TAMs) in Cancer Resistance; Modulation by Natural Products	19
1,3,4-thiadiazole: A Privileged Scaffold for Drug Design and Development	19
An Overview of Ovarian Cancer: Molecular Processes Involved and Development of Target-based Chemotherapeutics	19
The Tryptophan Catabolite or Kynurenine Pathway’s Role in Major Depression	19
Recent Efforts in the Discovery of Urease Inhibitor Identifications	19
Computational and Experimental Approaches to Investigate Lipid Nanoparticles as Drug and Gene Delivery Systems	19
Trends of Pharmaceutical Design of Endophytes as Anti-infective	18
Quinoline-based Compounds with Potential Activity against Drugresistant Cancers	18
Plant-food-derived Bioactives in Managing Hypertension: From Current Findings to Upcoming Effective Pharmacotherapies	18
Hyaluronan-based Multifunctional Nano-carriers for Combination Cancer Therapy	17
Membrane Derived Vesicles as Biomimetic Carriers for Targeted Drug Delivery System	17
Ziziphi Spinosae Semen: A Natural Herb Resource for Treating Neurological Disorders	17
Recent Developments of Flavonoids with Various Activities	17
Relevance of Aromatase Inhibitors in Breast Cancer Treatment	17
A Mini Review on Pharmacological Significance of Isatin-1,2,3-Triazole Hybrids	17
A Comprehensive Review on Current Perspectives of Flavonoids as Antimicrobial Agent	17
Potential Therapeutic Strategies of Phytochemicals in Neurodegenerative Disorders	17
Natural Bioactive as a Potential Therapeutic Approach for the Management of Cyclophosphamide-induced Cardiotoxicity	17
Traditional Uses, Pharmacological, and Phytochemical Studies of Euphorbia: A Review	16
The Anticancer Activity of Indazole Compounds: A Mini Review	16
Wnt/β-catenin Signaling Inhibitors	16
Breast Cancer Transcriptional Regulatory Network Reprogramming by using the CRISPR/Cas9 System: An Oncogenetics Perspective	16
Therapeutic Targets and Computational Approaches on Drug Development for COVID-19	15
Recent Developments of Coumarin-based Hybrids in Drug Discovery	15
Chalcone Derivatives and their Activities against Drug-resistant Cancers: An Overview	15
Multi-target Drug Discovery via PTML Modeling: Applications to the Design of Virtual Dual Inhibitors of CDK4 and HER2	15
Current Status of Novel Pyridine Fused Derivatives as Anticancer Agents: An Insight into Future Perspectives and Structure Activity Relationship (SAR)	15
Interaction of Platinum-based Drugs with Proteins: An Overview of Representative Crystallographic Studies	15
Advances in Computational Methods to Discover New NS2B-NS3 Inhibitors Useful Against Dengue and Zika Viruses	14
Machine Learning and Artificial Intelligence: A Paradigm Shift in Big Data-Driven Drug Design and Discovery	14
An Updated Review on Betacoronavirus Viral Entry Inhibitors: Learning from Past Discoveries to Advance COVID-19 Drug Discovery	14
Pyrimidine-fused Dinitrogenous Penta-heterocycles as a Privileged Scaffold for Anti-Cancer Drug Discovery	14
The Effects on Angiogenesis of Relevant Inorganic Chemotherapeutics	14
Nanomedicine and Early Cancer Diagnosis: Molecular Imaging using Fluorescence Nanoparticles	14
Therapeutic Potential of Indole Derivatives as Anti-HIV Agents: A Mini-review	14
Nanoscale Drug Delivery Systems for Glaucoma: Experimental and In Silico Advances	14
The Recent Development of Tetrahydro-Quinoline/Isoquinoline Based Compounds as Anticancer Agents	14

Discussion on the Structural Modification and Anti-tumor Activity of Flavonoids	14
Flavonoids as Sirtuin Modulators	14
Antidiabetic Potential of Naturally Occurring Sesquiterpenes: A Review	13
Impediment of Cancer by Dietary Plant-derived Alkaloids Through Oxidative Stress: Implications of PI3K/AKT Pathway in Apoptosis, Autophagy, and Ferroptosis	13
Anti-breast Cancer Potential of Natural and Synthetic Coumarin Derivatives	13
A Comprehensive Review on the Medicinal Importance; Biological and Therapeutic Efficacy of Lagenaria siceraria (Mol.) (Bottle Gourd) Standley Fruit	13
Coumarins as Potential Anti-drug Resistant Cancer Agents: A Mini Review	13
Structure and Functions of Bacterial Outer Membrane Protein A, A Potential Therapeutic Target for Bacterial Infection	13
Role of Phytomolecules in the Treatment of Obesity: Targets, Mechanisms and Limitations	13
Repurposing some of the Well-known Non-steroid Anti-inflammatory Drugs (NSAIDs) for Cancer Treatment	12
Exploring the Potential of Neuroproteomics in Alzheimer's Disease	12
1,2,3-Triazole Derivatives with Anti-breast Cancer Potential	12
Vascular Endothelial Growth Factor Receptors [VEGFR] as Target in Breast Cancer Treatment: Current Status in Preclinical and Clinical Studies and Future Directions	12
The Role of Peroxisome Proliferator-Activated Receptor in Addiction: A Novel Drug Target	12
Promising Essential Oils/Plant Extracts in the Prevention and Treatment of Dandruff Pathogenesis	12
Stem Cell Therapy in Combination with Naturopathy: Current Progressive Management of Diabetes and Associated Complications	12
Xanthones: A Class of Heterocyclic Compounds with Anticancer Potential	12
Natural and Synthetic Naphthoquinones as Potential Anti-Infective Agents	12
Imidazole Scaffold Based Compounds in the Development of Therapeutic Drugs	12
Recent Advances in the Application of Podophyllotoxin Derivatives to Fight Against Multidrug-Resistant Cancer Cells	12
Recent Advances in the Development of 1,2,3-Triazole-containing Derivatives as Potential Antifungal Agents and Inhibitors of Lanoster ol 14α-Demethylase	12
Ligand and Structure-based Virtual Screening of Lamiaceae Diterpenes with Potential Activity against a Novel Coronavirus (2019-nCoV)	12
Electrochemical Cell-based Biosensors for Biomedical Applications	12
Opuntia ficus indica(L.) Mill. An Ancient Plant Source of Nutraceuticals	11
Recent Updates on Pyrazoline Derivatives as Promising Candidates for Neuropsychiatric and Neurodegenerative Disorders	11
Metal-Organic Framework in Pharmaceutical Drug Delivery	11
A Medicinal Chemist’s Perspective Towards Structure Activity Relationship of Heterocycle Based Anticancer Agents	11
Predicting Metabolic Reaction Networks with Perturbation-Theory Machine Learning (PTML) Models	11
Solubility Enhancement of Methotrexate by Solid Nanodispersion Approach for the Improved Treatment of Small Cell Lung Carcinoma	11
Euglena Species: Bioactive Compounds and their Varied Applications	11
MicroRNAs as Potential Biomarkers in Coronary Artery Disease	11
OMICs Technologies for Natural Compounds-based Drug Development	11
Natural Flavonoids as Potential Therapeutics in the Management of Diabetic Wound: A Review	11
Juglone: A Versatile Natural Platform for Obtaining New Bioactive Compounds	11
Unleashing the Potential of Microbial Natural Products in Drug Discovery: Focusing on Streptomyces as Antimicrobials Goldmine	11
2,4,5-Trisubstituted Thiazole: A Privileged Scaffold in Drug Design and Activity Improvement	11
Therapeutic Potential of Naturally Occurring Benzofuran Derivatives and Hybrids of Benzofurans with other Pharmacophores as Antibacterial Agents	11
Chimeric Virus-like Particles of Universal Antigen Epitopes of Coronavirus and Phage Qβ Coat Protein Trigger the Production of Neutralizing Antibodies	11
Phytochemicals-based Therapeutics against Alzheimer's Disease: An Update	11
Glycyrrhetinic Acid and TAT Peptide Modified Dual-functional Liposomes for Treatment of Hepatocellular Cancer	10
Targeting Tumor Immunosuppressive Microenvironment for the Prevention of Hepatic Cancer: Applications of Traditional Chinese Medicines in Targeted Delivery	10
The Potential of Secondary Metabolites from Plants as Drugs or Leads against Trypanosoma cruzi-An Update from 2012 to 2021	10
Role of Extracellular Vesicles in Glioma Progression: Deciphering Cellular Biological Processes to Clinical Applications	10
Nutraceuticals and Bio-inspired Materials from Microalgae and their Future Perspectives	10
Cellular Bioenergetic and Metabolic Changes in Patients with Autism Spectrum Disorder	10
Advances in the Design and Development of PROTAC-mediated HDAC Degradation	10
Importance of Indazole against Neurological Disorders	10
Host Cell Proteases Mediating SARS-CoV-2 Entry: An Overview	10
The Antibacterial Activity of Isatin Hybrids	10
The G Protein Signal-Biased Compound TRV130; Structures, Its Site of Action and Clinical Studies	10
Carbon Monoxide as a Therapeutic for Airway Diseases: Contrast and Comparison of Various CO Delivery Modalities	10
The Reification of the Clinical Diagnosis of Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) as an Immune and Oxidative Stress Disorder: Construction of a Data-driven Nomothethic Network	10
Advancement of Prodrug Approaches for Nucleotide Antiviral Agents	10
Most Promising Compounds for Treating COVID-19 and Recent Trends in Antimicrobial & Antifungal Agents	10
GPRASP/ARMCX Protein Family: Potential Involvement in Health and Diseases Revealed by their Novel Interacting Partners	10
Drug-lead Anti-tuberculosis Phytochemicals: A Systematic Review	9
Nanostructured Transition Metal Sulfide-based Glucose and Lactic Acid Electrochemical Sensors for Clinical Applications	9
The Flavonoid Components of Scutellaria baicalensis: Biopharmaceutical Properties and their Improvement using Nanoformulation Techniques	9
Recent Advancements in Macrolide Hybrids against Staphylococcus aureus	9
Next-generation Bruton’s Tyrosine Kinase (BTK) Inhibitors Potentially Targeting BTK C481S Mutation- Recent Developments and Perspectives	9
Nanogel-based Transdermal Drug Delivery System: A Therapeutic Strategy with Under Discussed Potential	9
Pyrazole; A Privileged Scaffold of Medicinal Chemistry: A Comprehensive Review	9
Recent Advances in Computer-aided Virtual Screening and Docking Optimization for Aptamer	9
A Natural Membrane Vesicle Exosome-based Sinomenine Delivery Platform for Hepatic Carcinoma Therapy	9
Nitrogen-containing Heterocycle: A Privileged Scaffold for Marketed Drugs	9
A Quinquennial Review on Recent Advancements and Developments in Search of Anti-malarial Agents	9
Impact of Indazole Scaffold as Antibacterial and Antifungal Agent	9
The Role of Flavonoids in Inhibiting IL-6 and Inflammatory Arthritis	9
Understanding the Phytoestrogen Genistein Actions on Breast Cancer: Insights on Estrogen Receptor Equivalence, Pleiotropic Essence and Emerging Paradigms in Bioavailability Modulation	9
A Multi-target Drug Designing for BTK, MMP9, Proteasome and TAK1 for the Clinical Treatment of Mantle Cell Lymphoma	9
Electrochemical Nanomaterial-based Sensors/Biosensors for Drug Monitoring	9
Detection of Natural Inhibitors against Human Liver Cancer Cell Lines through QSAR, Molecular Docking and ADMET Studies	9
Phosphodiesterase as a Target for Cognition Enhancement in Schizophrenia	9
Exploring Multiple Sclerosis (MS) and Amyotrophic Lateral Scler osis (ALS) as Neurodegenerative Diseases and their Treatments: A Review Study	9
Review on the Developments of Benzothiazole-containing Antimicrobial Agents	9
Organic Antifungal Drugs and Targets of Their Action	9
The Antibacterial Activity of Quinazoline and Quinazolinone Hybrids	9
Potential Therapeutic Relevance of CRISPR/Cas9 Guided Epigenetic Regulations for Neuropsychiatric Disorders	9
A Review of the Biological Activities of Heterocyclic Compounds Comprising Oxadiazole Moieties	9
Production of Effective Phyto-antimicrobials via Metabolic Engineering Strategies	8

4-Aryl-1,4-Dihydropyridines as Potential Enoyl-Acyl Carrier Protein Reductase Inhibitors: Antitubercular Activity and Molecular Docking Study	8
Therapeutics for the Management of Cytokine Release Syndrome in COVID-19	8
Amino Acid Derived Prodrugs: An Approach to Improve the Bioavailability of Clinically Approved Drugs	8
Recent Advancements in the Synthesis and Chemistry of Benzo-fused Nitrogen- and Oxygen-based Bioactive Heterocycles	8
Advancement in Nanoparticle-based Biosensors for Point-of-care In vitro Diagnostics	8
1,3,4-Oxadiazoles as Potential Pharmacophore for Cytotoxic Potentiality: A Comprehensive Review	8
Electrochemical Biosensors for Monitoring of Drug-DNA Interactions	8
Therapeutic Potential and Molecular Mechanisms of the Multitargeted Flavonoid Fisetin	8
Repurposing of Chemotherapeutics to Combat COVID-19	8
Application of a Novel Metallomics Tool to Probe the Fate of Metal-Based Anticancer Drugs in Blood Plasma: Potential, Challenges and Prospects	8
PTML Multi-Label Algorithms: Models, Software, and Applications	8
Multi-target Polypharmacology of 4-aminoquinoline Compounds against Malaria, Tuberculosis and Cancer	8
Hybridization Approach to Drug Discovery Inhibiting Mycobacterium tuberculosis-An Overview	8
Efficiency of Homology Modeling Assisted Molecular Docking in G-protein Coupled Receptors	8
Nanotechnology Assisted Chemotherapy for Targeted Cancer Treatment: Recent Advances and Clinical Perspectives	8
Recent Progress in Oleanolic Acid: Structural Modification and Biological Activity	8
Mechanisms of Metallic Nanomaterials to Induce an Antibacterial Effect	8
High-resolution MD Simulation Studies to Get Mechanistic Insights into the Urea-induced Denaturation of Human Sphingosine Kinase 1	8
Advances in Nanomaterial-based Biosensors for Determination of Glycated Hemoglobin	8
Recent Development in Fluorescent Probes for Copper Ion Detection	7
HDAC Inhibition as Neuroprotection in COVID-19 Infection	7
Therapeutic Potential of microRNA Against Th2-associated Immune Disorders	7
In vivo Anticancer Potential of Hydroxamic Acid Derivatives	7
Caralluma edulis (Apocynaceae): A Comprehensive Review on its Traditional Uses, Phytochemical Profile and Pharmacological Effects	7
The Hybrid Compounds as Multi-target Ligands for the Treatment of Alzheimer's Disease: Considerations on Donepezil	7
Multi-target Approaches of Epigallocatechin-3-O-gallate (EGCG) and its Derivatives against Influenza Viruses	7
β-Lactone Derivatives and Their Anticancer Activities: A Short Review	7
Bis-triazole-containing Compounds with Anticancer Potential: A Short Review	7
Recent Development of Heterocyclic Compounds with Indazole Moiety as Potential Antiparasitic Agents	7
Computational Approaches in the Discovery and Development of Therapeutic and Prophylactic Agents for Viral Diseases	7
ATP Synthase Inhibitors as Anti-tubercular Agents: QSAR Studies in Novel Substituted Quinolines	7
Key Advances in MIP-based Sensors Applied for Cancer and Cardiovascular Biomarkers Detection	7
Insight into the Isolation, Synthesis, and Structure-Activity Relationship of Piperine Derivatives for the Development of New Compounds: Recent Updates	7
In-silico Studies and Wet-Lab Validation of Camptothecin Derivatives for Anti-Cancer Activity Against Liver (HepG2) and Lung (A549) Cancer Cell Lines	7
Medicinal Chemistry Strategies Towards SO2 Donors as Research Tools and Potential Therapeutics	7
ENTPDases from Pathogenic Trypanosomatids and Purinergic Signaling: Shedding Light towards Biotechnological Applications	7
Spotlight on the Selected New Antimicrobial Innate Immune Peptides Discovered During 2015-2019	7
Phenanthrene Dimers: Promising Source of Biologically Active Molecules	7
Antiangiogenic Therapy: Challenges and Future Directions	7
Exploring the Multitarget Potential of Iridoids: Advances and Applications	7
Aberrant Lipid Metabolism in Cancer: Current Status and Emerging Therapeutic Perspectives	7
Hepatocellular Carcinoma Targeting and Pharmacodynamics of Paclitaxel Nanoliposomes Modified by Glycyrrhetinic Acid and Ferric Tetroxide	7
Synthesis and Evaluation of Antimicrobial Activity and Molecular Docking of New N-1,3-thiazol-2-ylacetamides of Condensed Pyrido[3',2':4,5] furo(thieno)[3,2-d]pyrimidines	7
Contrasting Roles of the Galectin-3 in the Schizophrenia Onset, Clinical Presentation, and Somatic Comorbidity	7
Application of In silico Methods in the Design of Drugs for Neurodegenerative Diseases	7
Bioinformatics Paradigms in Drug Discovery and Drug Development	7
Dibenzofurans from Lichens – A Pharmacological Overview	6
Aminoglycosides with Anti-MRSA Activity: A Concise Review	6
Immunomodulatory Effects of Allium sativum L. and its Constituents against Viral Infections and Metabolic Diseases	6
Engineering “Antimicrobial Peptides” and Other Peptides to Modulate Protein-Protein Interactions in Cancer	6
Multifunctional Nanoparticles in Precise Cancer Treatment: Considerations in Design and Functionalization of Nanocarriers	6
Vitamin D and its Possible Relationship to Neuroprotection in COVID-19: Evidence in the Literature	6
Drug Discovery and Target Identification against Schistosomiasis: A Reality Check on Progress and Future Prospects	6
Indoleamine 2,3-dioxygenase (IDO)-activity in Severe Psychiatric Disorders: A Systemic Review	6
Review on Pharmacological and Phytochemical Prospects of Traditional Medicinal Plant: Persicaria hydropiper (Smartweed)	6
Progress in Studies on Structural and Remedial Aspects of Newly Born Coronavirus, SARS-CoV-2	6
Molecular Characterization of Primary and Metastatic Colon Cancer Cells to Identify Therapeutic Targets with Natural Compounds	6
Piperidine Nucleus as a Promising Scaffold for Alzheimer’s Disease: Current Landscape and Future Perspective	6
Current Approaches in Diabetes Treatment and Other Strategies to Reach Normoglycemia	6
Steroid and Triterpenoid Compounds with Antiparasitic Properties	6
A Review on Green Synthesis of Silver Nanoparticles and its Role against Cancer	6
Beyond DNA-targeting in Cancer Chemotherapy. Emerging Frontiers - A Review	6
Indirect-Acting Pan-Antivirals vs. Respiratory Viruses: A Fresh Perspective on Computational Multi-Target Drug Discovery	6
Natural Products as Potential Therapeutic Agents for SARS-CoV-2: A Medicinal Chemistry Perspective	6
Embryonic Ectoderm Development (EED) as a Novel Target for Cancer Treatment	6
Matrix Metalloproteinases (MMPs) in Targeted Drug Delivery: Synthesis of a Potent and Highly Selective Inhibitor against Matrix Metalloproteinase-7	6
Sterol 14α-Demethylase from Trypanosomatidae Parasites as a Promising Target for Designing New Antiparasitic Agents	6
The Design of Multi-target Drugs to Treat Cardiovascular Diseases: Two (or more) Birds on One Stone	6
Current Scenario of Acridine Hybrids with Anticancer Potential	6
Current Perspective of ATP Synthase Inhibitors in the Management of the Tuberculosis	6
Oxidative Stress in the Early Stage of Psychosis	6
The Antibacterial Potential of Ciprofloxacin Hybrids against Staphylococcus aureus	6
The Antiproliferative Activity of Ferrocene Derivatives against Drug- Resistant Cancer Cell Lines: A Mini Review	6
Quantitative Structure-activity Relationships; Studying the Toxicity of Metal Nanoparticles	6
Extracellular Matrix Remodeling Biomarkers in Coronary Artery Disease	6