Current Topics in Medicinal Chemistry

Papers
(The TQCC of Current Topics in Medicinal Chemistry is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)
ArticleCitations
Privileged Scaffold for Drug Design and Activity Improvement - Part IV115
Recent Developments in the Therapeutics for Endocrine Diseases70
Recent Advances in the Use of Multitarget Therapeutics69
The Role of Herbal Medicine in Modulating Bone Homeostasis53
Fighting Antimicrobial Resistance with Natural Products - Current Developments and Future Prospects50
Qi Yin San Liang San Decoction Relieves Gefitinib-Induced Diarrhea via the Modulation of Chemokines and Innate Immune Responses48
Synthesis of Isatin-derived Heterocycles with Promising Anticancer Activities46
Green Synthesis of Biorelevant Scaffolds through Organocatalytic/ Enzymatic Dynamic Kinetic Resolution45
Next-generation Bruton’s Tyrosine Kinase (BTK) Inhibitors Potentially Targeting BTK C481S Mutation- Recent Developments and Perspectives42
Optimization, Preparation, and Cytotoxic Potential of Pyrus communis Extract Loaded Ethosomes on Skin Cancer Cell Lines41
Valeriana jatamansi: Bioactive Compounds and their Medicinal Uses40
Tackling Nontuberculous Mycobacteria by Repurposable Drugs and Potential Leads from Natural Products38
Application of Virtual Sample Generation and Screening in Process Parameter Optimization of Botanical Medicinal Materials36
Modern Approaches to Diabetes: The Role of Phytochemicals in Targeting Molecular Receptors35
The Gut Microbiota-Brain Axis: Potential Mechanism of Drug Addiction33
Computer-aided Drug Discovery of Epigenetic Modulators in Dual-target Therapy of Multifactorial Diseases33
Eco-friendly Approaches to Chromene Derivatives: A Comprehensive Review of Green Synthesis Strategies31
Bioactivity of Natural Products as Complementary Medicine30
Discovery of MMP1 Inhibitors from Dandelion using Molecular Simulation and Bioactivity Test30
From Nature to Drug: Overview and CADD Approach of Anacardic Acid to Propose their Biological Potential30
Natural Multi-targets: Advances and Applications28
Hydrogen-producing Photocatalyst at Sunscreen for Athletes in Preventing and Healing Muscle-nerve-skin Injuries27
Current Advances in Drug Design and Cancer Research27
Probing into the Flap-dimer Dynamics of the Mycobacterium tuberculosis Kasa Enzyme Binding Landscape Provides the Underlying Inhibitory Mechanisms of JSF-3285 and 5G26
Recent Advances in the Design and Synthesis of Small Molecule Carbonic Anhydrase IX Inhibitors26
Bioanalysis, Analysis, Chemistry, and Pharmacological Aspects of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors26
Current Organoid Culture Systems in Pancreatic Cancer25
Wnt/β-catenin Signaling Inhibitors25
Cinchonine: A Versatile Pharmacological Agent Derived from Natural Cinchona Alkaloids25
The Multitarget Action of Vitamins in the Ischemic Stroke25
Effect of Withaferin-A, Withanone, and Caffeic Acid Phenethyl Ester on DNA Methyltransferases: Potential in Epigenetic Cancer Therapy24
Exploring the Carbonic Anhydrase Activation Properties of 4-arylazo-3,5- diamino-1H-pyrazoles against hCA I, II, IV, and VII isoenzymes24
Nutritional Value, Therapeutic Effects, Phytochemistry, and Toxicology of Lepisanthes fruticosa: A Review24
Unlocking the Multifunctional Therapeutic Potential of Manassantin: A Lignan-Derived Scaffold24
Recent Advances in Metallic Nanostructures-assisted Biosensors for Medical Diagnosis and Therapy24
Calotropis procera (Aiton) Dryand (Apocynaceae): State of the art of its uses and Applications23
Artificial Intelligence and Cheminformatics-Guided Modern Privileged Scaffold Research23
Finding Integrative Medication for Neuroblastoma and Glioblastoma through Zebrafish as A Model of Organism23
Repurposing some of the Well-known Non-steroid Anti-inflammatory Drugs (NSAIDs) for Cancer Treatment23
Oxidative Stress Biomarkers in Coronary Artery Disease23
Epigenetics Mechanism and Therapeutic Potential of Approved Epi-drugs in Pulmonary Hypertension Disease22
Novel Biomarkers in Cardiovascular Diseases: Going beyond Troponins and Natriuretic Peptides - Part 122
Drug Delivery Systems for Natural Medicines in Cancer Therapy22
Acknowledgements to Reviewers22
Exploring New Vista for Alzheimer's Disease Drug Targets21
Novel Therapeutic Strategies for the Management of Neuropathology and Neuroprotection in COVID-1921
Biosensors in Diagnostics and Medicinal Applications Part (II)20
Various Effects of the GABAergic System on Cancer: The Conditions and Specificities of its use in the Treatment of Some Cancers20
Highlighting the Therapeutic Potential of an Underexplored Target: Human Dihydroorotate Dehydrogenase in Cancer, Rheumatoid Arthritis and Sclerosis19
Insight into Tumor Hypoxia: Radionuclide-based Biomarker as Diagnostic Tools19
To Investigate Growth Factor Receptor Targets and Generate Cancer Targeting Inhibitors19
Role of Plant Materials with Anti-inflammatory Effects in Phytotherapy of Osteoarthritis19
Effects of Flavonoids in Experimental Models of Arterial Hypertension19
Conformation Study and Design of Novel 6-Hydroxybenzothiazole-2- Carboxamides as Potentially Potent and Selective Monoamine Oxidase B Inhibitors for Neuroprotection19
Review on the Developments of Benzothiazole-containing Antimicrobial Agents18
QSAR into the New Millennium: Structural, Topological, Quantum, Shape, Electronic and Bio Descriptors for Machine Learning & AI - Honoring Prof. Satya Prakash Gupta18
Plant-food-derived Bioactives in Managing Hypertension: From Current Findings to Upcoming Effective Pharmacotherapies18
Precision Psychiatry: Machine Learning as a Tool to Find New Pharmacological Targets18
Medicinal Chemistry and Target Identification of Synthetic Clinical and Advanced Preclinical Antimalarial Candidates (2000 - 2022)18
Recent Biochemical Advances in Antitubercular Drugs: Challenges and Future18
Chemical Composition, Acetylcholine Esterase and Anti-bacterial Activities of Essential Oils of Elaeosilenum thapsioides (Desf.) Maire from Algeria18
Synthesis of Biorelevant Scaffolds under Greener Conditions (Part: 2)17
Advances in Small Molecules of Flavonoids for the Regulation of Gluconeogenesis17
Application of Artificial Intelligence-Based Approaches in the Discovery and Development of Protein Kinase Inhibitors (PKIs) Targeting Anticancer Activity17
Carboxamide: A Privileged Pharmacophore for the Development of Anti-infectious and Anti-cancer Drugs17
Preface17
Lipoprotein-associated Phospholipase A2 in Coronary Artery Disease17
Phytotherapeutics in Cancer: From Potential Drug Candidates to Clinical Translation17
Medicinal Chemistry for Sustainable Development17
Recent Developments in Indazole Scaffold towards Prevention and Treatment of Various Health Disorders17
Guchang Zhixie Pill: A Comprehensive Review of the Clinical Applications, Toxicological Profile, and Quality Markers17
Phytochemicals of Biologically Active Fractions from Silene conoidea Leaves and Stems17
Self-assembled Nucleic Acid Nanostructures for Biomedical Applications16
Recent Insights into Osimertinib Analogues against EGFR Positive Non-small Cell Lung Cancer16
A Review on Indole-triazole Molecular Hybrids as a Leading Edge in Drug Discovery: Current Landscape and Future Perspectives16
The Potential of Secondary Metabolites from Plants as Drugs or Leads against Trypanosoma cruzi-An Update from 2012 to 202116
An Update on Pharmacological and Phytochemical Aspects of Costus pictus D. Don - A Promising Anti-diabetic Plant16
Recent Advances in the Multistep Continuous Preparation of APIs and Fine Chemicals16
Importance of Indazole against Neurological Disorders15
Synthesis and Antimycobacterial Activity of Isoniazid Derivatives Tethered with Aliphatic Amines15
A Comprehensive Review on Phytochemistry and Pharmacology ofRosaSpecies (Rosaceae)15
Recent Applications of Bioinformatics in Target Identification and Drug Discovery for Alzheimer’s Disease14
A New Advanced Approach: Design and Screening of Affinity Peptide Ligands Using Computer Simulation Techniques14
Profiling of Polyphenolic Compounds, Antioxidant, Antidyslipidemic and Cardiac Risk Preventive Effect of Keteki Joha and Kola Joha Rice Cultivars Grown in Assam, India: A Comparative Study14
Multimodal Activity of a Novel Compound against Prostate and Pancreatic Cancer14
A Compressive Review on Source, Toxicity and Biological Activity of Flavonoid14
Recent Developments in Microfluidic Paper-based Analytical Devices for Pharmaceutical Analysis14
100 Years of Insulin: A Historical Perspective13
Drug Repurposing Meets DNA Independent Pathways: Targeting Alternative Substrates for Anticancer Therapy13
A Comprehensive Review on the Antimicrobial Activity of the Genus Artemisia, Artemisinin, and its Derivatives13
The Role of Cytokines in Activation of Tumour-promoting Pathways and Emergence of Cancer Drug Resistance13
Machine Learning and Artificial Intelligence: A Paradigm Shift in Big Data-Driven Drug Design and Discovery13
Hybrid Compounds in Polypharmacology13
Acknowledgement to Reviewers13
Identification and Verification of a Prognostic Risk Signature in Oral Squamous Cell Carcinoma13
Research Progress in Chemical Synthesis and Biosynthesis of Bioactive Pyridine Alkaloids12
A Concise Review on the Role of Natural and Synthetically Derived Peptides in Colorectal Cancer12
A Comprehensive Review on Current Perspectives of Flavonoids as Antimicrobial Agent12
Roles of C/EBPβ/AEP in Neurodegenerative Diseases12
Recent Progress in 1H-1,2,3-triazoles as Potential Antifungal Agents12
Selected Natural and Synthetic Agents Effective against Parkinson’s Disease with Diverse Mechanisms12
Prodrug Strategies for Critical Drug Developability Issues: Part II12
Therapeutics for the Management of Cytokine Release Syndrome in COVID-1912
Pharmacological and Therapeutic Potential of Berbamine: A Potent Alkaloid from Genus Berberis12
Flavonoid Derivatives Targeting BCR-ABL Kinase: Semisynthesis, Molecular Dynamic Simulations and Enzymatic Inhibition12
Molecular Modeling Techniques Applied to the Design of Multitarget Drugs: Methods and Applications12
A Review of the Biological Activities of Heterocyclic Compounds Comprising Oxadiazole Moieties11
Physicochemical Significance of Topological Indices: Importance in Drug Discovery Research11
Antiviral Effects and Mechanisms of Green Tea Catechins on Influenza: A Perception on Combating Symptoms from COVID-1911
Impact of TRP Channels in Oral Pathology and Therapeutic Targeting Options: A Narrative Review11
Reviewing the Synthesis and Clinical Application of FDA-approved Anticancer Medications11
Medicinal Chemistry Advancement in Life-Threatening Diseases11
The Current Landscape in the Development of Small-molecule Modulators Targeting Sphingosine-1-phosphate Receptors to Treat Neurodegenerative Diseases11
Neuroprotective Role of Phytoconstituents-based Nanoemulsion for the Treatment of Alzheimer’s Disease11
LINC-PINT: A Distinctive Long Non-Coding RNA Functioning as a Potential Suppressor in Tumorigenesis11
Decoding Dementia Mechanisms: Identification of Key Oligodendrocyte-Associated Genes through Integrative Bioinformatics and Machine Learning11
Noncoding RNAs in Alzheimer’s Disease: Overview of Functional and Therapeutic Significance10
Recent Advances in Drug Discovery for Parasitic Diseases10
Bioassay Guided Isolation and α-Glucosidase Inhibition Studies of a New Sesquiterpene from Ochradenus aucheri10
Non-vesicular Lipid Transport Machinery in Trichomonas vaginalis: Novel Drug Targets against Trichomoniasis10
Review the Role of Metabolism Reprogramming in the Pathogenesis of Post-surgical Adhesion: A New Therapeutic Strategy10
Use of Immunoglobulin Y Antibodies: Biosensor-based Diagnostic Systems and Prophylactic and Therapeutic Drug Delivery Systems for Viral Respiratory Diseases10
1,3,4-Oxadiazoles as Potential Pharmacophore for Cytotoxic Potentiality: A Comprehensive Review10
Imidazole Scaffold Based Compounds in the Development of Therapeutic Drugs10
4-Nerolidylcatechol (4-NC) and Docetaxel Synergize in Controlling Androgen- independent Prostate Cancer Cells10
Flavonoid: A Natural Scaffold with Modulatory Activities on Diverse Cellular Signaling Pathways Related to Complex Diseases10
Phytochemicals for Human Health: The Emerging Trends and Prospects, Part-210
The Functional Mechanism and Structure-Activity Relationship of Antibacterial Peptides10
Benzothiazole as a Promising Scaffold for the Development of Antifungal Agents9
A Mini Review on Pharmacological Significance of Isatin-1,2,3-Triazole Hybrids9
Employing “Red Flags” to Fight the Most Neglected Diseases: Nitroaromatic as Still Suitable Tools to Treat Human and Veterinary Parasitosis9
Coptis Chinensis Franch: Substance Basis, Mechanism of Action and Quality Control Standard Revealed Based on the Q-marker Concept and New Strategy of Systemic Pharmacology and Biosynthesis Rese9
Antiproliferative Activity and Mechanisms of Action of Plant-derived Flavonoids on Breast Cancer9
Heterocyclic Phytochemicals as Anticancer Agents9
Multi-target Polypharmacology of 4-aminoquinoline Compounds against Malaria, Tuberculosis and Cancer9
Neuroactive Phytoconstituents of Glycyrrhiza glabra for the Treatment of Alzheimer’s Disease9
Exploration of Computational Aids for Effective Drug Designing and Management of Viral Diseases: A Comprehensive Review9
Naturally Occurring Steroidal Saponins as Potential Anticancer Agents: Current Developments and Mechanisms of Action9
In Silico and In Vivo Hepatorenal Protective Effect of Chitosan-Loaded Chrysin Nanoparticles in Obese Rats9
A Comprehensive Review on the Application of Marketed Drugs as Ligands through Metallopharmaceutics9
Discovery of Diphenylsilane Compounds as Potential Inhibitors of Zn-Metalloproteinase Thermolysin Using Artificial Neural Networks9
Recent Strategies and Challenges in Immunity and Nanomaterials for Cancer Therapy9
Psychedelics and Hallucinogens in Psychiatry: Finding New Pharmacological Targets9
Advances in the Study of Halogenated Natural Products9
Aminoglycosides with Anti-MRSA Activity: A Concise Review9
Green Synthetic and Pharmacological Developments in the Hybrid Quinazolinone Moiety: An Updated Review9
The Design of Multi-target Drugs to Treat Cardiovascular Diseases: Two (or more) Birds on One Stone9
Advances in Nanomaterial-based Biosensors for Determination of Glycated Hemoglobin9
Navigating the Alzheimer's Treatment Landscape: Unraveling Amyloid-beta Complexities and Pioneering Precision Medicine Approaches9
Ziziphi Spinosae Semen: A Natural Herb Resource for Treating Neurological Disorders9
Adhesion Molecules as Prognostic Biomarkers in Coronary Artery Disease9
An Overview on Antifilarial Efficacy of Heterocyclic Motifs Encompassing Synthetic Strategies, SAR and Commercialized Medications9
Juglone: A Versatile Natural Platform for Obtaining New Bioactive Compounds9
Biofunctionalized Nano-antimicrobials - Progress, Prospects and Challenges8
A Comprehensive Review of Pharmacokinetics and Pharmacodynamics in Animals: Exploration of Interaction with Antibiotics of Shuang-Huang- Lian Preparations8
A Comprehensive Review of mRNA-based Vaccines for COVID-19, A New Era in Pharmaceuticals: Unspecified and Unknown Aspects, Effects and Challenges8
Molecular Characterization of Primary and Metastatic Colon Cancer Cells to Identify Therapeutic Targets with Natural Compounds8
A Review of Computational Approaches Targeting SARS-CoV-2 Main Protease to the Discovery of New Potential Antiviral Compounds8
Natural Products as Sources of Multitarget Compounds: Advances in the Development of Ferulic Acid as Multitarget Therapeutic8
Synthesis, X-Ray Structure, Characterization, Antifungal Activity, DFT, and Molecular Simulation of a Novel Pyrazole Carboxylic Acid8
Unveiling Anti-Cancer Potential through ADMET Prediction, Molecular Docking, Molecular Dynamics, and In vitro Analysis: Approach to Establish Alpha-Terpineol as a Potential Drug Candidate against Glio8
Recent Development of Heterocyclic Compounds with Indazole Moiety as Potential Antiparasitic Agents8
HDAC Inhibition as Neuroprotection in COVID-19 Infection8
Neurobiology of Dream Activity and Effects of Stimulants on Dream8
Recent Efforts in the Discovery of Urease Inhibitor Identifications8
Recent Advances in the Development of Nitrogen-containing Heterocyclic Anti-alzheimer’s Agents8
Therapeutic Potential of Quercetin in Diabetic Neuropathy and Retinopathy: Exploring Molecular Mechanisms8
Relevance of Aromatase Inhibitors in Breast Cancer Treatment8
Hybrid Molecules with Potential Activity Against Methicillin-resistance Staphylococcus aureus Part I8
Nutraceuticals and Bio-inspired Materials from Microalgae and their Future Perspectives8
Update on Modulators of Quorum Sensing Pathways in Pseudomonas aeruginosa8
Targeting c-Met in Cancer Therapy: Unravelling Structure-activity Relationships and Docking Insights for Enhanced Anticancer Drug Design8
Stimuli-sensitive Chitosan-based Nanosystems-immobilized Nucleic Acids for Gene Therapy in Breast Cancer and Hepatocellular Carcinoma8
Oxyprenylated Secondary Metabolites as Modulators of Lipid and Sugar Metabolism8
Recent Advances in Chemical Composition and Transdermal Delivery Systems for Topical Bio-actives in Skin Cancer8
Harnessing the Therapeutic Potential of Antimicrobial Peptides for Cancers: State of the Art8
Quantitative Structure Activity/Toxicity Relationship through Neural Networks for Drug Discovery or Regulatory Use8
Nanomaterial-based Electrochemical Sensors for Multiplex Medicinal Applications8
SRT1720 Treatments Hepatic Ischemia Reperfusion Injury by Regulation of NF-κB Signaling Pathways and Reduce Cell Apoptosis: From Network Pharmacology to Experimental Validation7
Melanin Synthesized by the Endophytic Aureobasidium Pullulans AKW: A Multifaceted Biomolecule with Antioxidant, Wound Healing, and Selective Anti-Cancer Activity7
Polymer Conjugate as the New Promising Drug Delivery System for Combination Therapy against Cancer7
Ethnobotanical Study of Knowledge and Herbal Recipes of Medicinal Plants in Ancient Izki, Al Dakhliya Region, Sultanate of Oman7
A Review on Aptamers Selection and Application in Heart Diseases Diagnosis7
Advancements and Scientific Partnerships in the Application of Polysaccharides in Oral Formulations: A Bibliometric Analysis and Review7
Exploring the Structure-Activity Relationship of COX Inhibitors with Anticancer Effects: A Comprehensive Review7
Ameliorative Effects of Essential Oils on Diabetes Mellitus: A Review7
Recent Advances in Nanocatalyzed One-Pot Sustainable Synthesis of Bioactive N, N-Heterocycles with Anticancer Activities: An Outlook of Medicinal Chemistry7
Clinical Research Progress of BTK Inhibitors in the Treatment of Autoimmune Diseases7
Electrochemical Protein-based Bioanalytical Devices for Drug Analysis7
Mining of Targeted Therapeutic Drugs for Hepatocellular Carcinoma based on Programmed Death-related Features and Construction of an Imaging Histology Diagnostic Model7
Targeting Various Pathogenic Pathways for the Development of Anti-alzheimer’s Drugs: An Update7
Transforming Breast Cancer Therapy: The Pivotal Role of Nanoparticles7
The Vital Role of Long Non-Coding RNA SUMO1P3 in the Regulation of Human Cancer: Current Perspectives and Future Challenges7
Recent Advances in Di-, Tri-Substituted Mono-Thiazoles, and Bis-Thiazoles: Factors Affecting Biological Activities, Future Aspects, and Challenges7
Pharmacological Chemistry and Biomedical Implications of Chemical Ingredients from Parthenium hysterophorus7
The Impact and Role of Artificial Intelligence (AI) in Healthcare: Systematic Review7
5-Membered Heterocyclic Compounds as Antiviral Agents7
CADD Methods for Developing Novel Compounds Synthesized to Inhibit Tyrosine Kinase Receptors7
Mechanisms of Metallic Nanomaterials to Induce an Antibacterial Effect7
An Updated Overview of Synthetic α-glucosidase Inhibitors: Chemistry and Bioactivities7
Probing the Interaction of Selonsertib with Human Serum Albumin: In silico and In vitro Approaches7
Nano-cocrystals as Nanotechnology-based Approach to Modulate Solubility and Bioavailability of Poorly Soluble Drugs7
The Computational Tools to Identify DNA Repeats and Motifs: A Systematic Review6
Synthesis of New Axially Coumarin Disubstituted Silicon(IV) Phthalocyanines, Investigation of their DNA-Binding Properties and Inhibitory Activities on Ache and Buche6
Advances in Cervical Cancer Diagnostics Based on Immunosensors: Innovative Approaches and Tumor Biomarkers6
Nanoscale Structures and Materials from the Self-assembly of Polypeptides and DNA6
Clinical Indicators of Oral Frailty: A Domain-Specific Frailty Phenotype6
Integrative Analysis Reveals Genes Causal Relation with Ovarian Cancer and aging6
The Future of Medicine: AI and ML Driven Drug Discovery Advancements6
Oxazolidinone-containing Hybrids with Antibacterial Activity against Methicillin-resistant Staphylococcus aureus (MRSA): A Mini-review6
Anti-apoptotic and Anti-oxidative Effects of Aqueous Extract prepared from Steamed Daylily Flower in Normal Cardiac and Hepatic Cells against Ethanol.6
Research Progress on the Mechanisms of Traditional Chinese Medicine in Preventing and Treating HCC Invasion and Metastasis Based on Lipid Metabolic Reprogramming6
Natural Antioxidants as Additional Weapons in the Fight against Malarial Parasite6
The General Neurocognitive Decline in Patients with Methamphetamine Use and Transient Methamphetamine-induced Psychosis is Primarily Determined by Oxidative and AGE-RAGE Stress6
Natural-Derived Products and Nanomaterials for the Treatment of Cancer and Chronic Disorders (Part 1)6
Synthetic Strategies for the Development of Ibuprofen Derivatives: A Classified Study6
Microalgae and Human Disorders: Mechanistic Insights and Therapeutic Potential6
Natural Plant Products Mediated Prevention of Cancer Facilitated through Immune Suppression of Treg Cells6
Facile Synthesis and Applications of Flavonoid-Heterocyclic Derivatives6
Protein Dynamics Mediated by Cardiolipin in Bacteria6
Microfluidics-mediated Liposomal Nanoparticles for Cancer Therapy: Recent Developments on Advanced Devices and Technologies6
Coumarin as a Privileged and Medicinally Important Scaffold in the Treatment of Tuberculosis6
Synthesis and In vitro and In silico Anti-inflammatory Activity of New Thiazolidinedione-quinoline Derivatives6
MicroRNAs as Potential Biomarkers in Coronary Artery Disease6
Bergenin - A Biologically Active Scaffold: Nanotechnological Perspectives6
Therapeutic Potential of Quercetin in Type 2 Diabetes Based on a Network Pharmacology Study6
Ginsenoside Rg3: A Review of its Anticancer Mechanisms and Potential Therapeutic Applications6
Current Therapeutic Strategies for the Management of Benzodiazepine (BZD) Withdrawal Syndrome: A Review6
Nanocarriers as Administration Systems of Natural Products6
2,3-Diarylindoles as COX-2 Inhibitors: Exploring the Structure-activity Relationship through Molecular Docking Simulations6
Non-fused Pyrimidine Derivatives as Potential Pharmacological Entities: A Review6
In vivo PET Imaging of EGFR Expression: An Overview of Radiolabeled EGFR TKIs6
0.18318605422974