Current Cancer Drug Targets

Papers
(The TQCC of Current Cancer Drug Targets is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)
ArticleCitations
Advances in Ovarian Cancer Treatment Beyond PARP Inhibitors38
The Therapeutic Potential of MAPK/ERK Inhibitors in the Treatment of Colorectal Cancer27
Role of Tumor Microenvironment in Cancer Stem Cells Resistance to Radiotherapy26
The Role of RNA Modifications and RNA-modifying Proteins in Cancer Therapy and Drug Resistance24
Crosstalk of Long Non-coding RNAs and EMT: Searching the Missing Pieces of an Incomplete Puzzle for Lung Cancer Therapy22
Nanotechnology-enabled Chemodynamic Therapy and Immunotherapy22
Role of ZEB Family Members in Proliferation, Metastasis, and Chemoresistance of Prostate Cancer Cells: Revealing Signaling Networks21
C-Myc Signaling Pathway in Treatment and Prevention of Brain Tumors20
Protectors of the Mitochondrial Permeability Transition Pore Activated by Iron and Doxorubicin19
Exosome as a Natural Gene Delivery Vector for Cancer Treatment18
The Potential of Natural Products in the Treatment of Triple-negative Breast Cancer17
Antibody-drug Conjugate Targets, Drugs, and Linkers16
MUC Glycoproteins: Potential Biomarkers and Molecular Targets for Cancer Therapy16
Recent Progress in Histone Deacetylase (HDAC) 1 Inhibitors as Anticancer Agent15
Traditional and Novel Computer-Aided Drug Design (CADD) Approaches in the Anticancer Drug Discovery Process15
The Therapeutic Potential of Urolithin A for Cancer Treatment and Prevention14
Resistance of Lenvatinib in Hepatocellular Carcinoma13
The Activation of Procarcinogens by CYP1A1/1B1 and Related Chemo-Preventive Agents: A Review13
Current and Future Therapeutic Targets: A Review on Treating Head and Neck Squamous Cell Carcinoma12
Epigenetic Mechanisms of Therapy Resistance in Diffuse Large B Cell Lymphoma (DLBCL)12
Tumor Penetrating Peptide-Functionalized Tenascin-C Antibody for Glioblastoma Targeting12
Selinexor (KPT-330), an Oral Selective Inhibitor of Nuclear Export (SINE) Compound, in Combination with FOLFOX in Patients with Metastatic Colorectal Cancer (mCRC) - Final Results of the Phase I Trial11
A Molecular Link Between Diabetes and Breast Cancer: Therapeutic Potential of Repurposing Incretin-based Therapies for Breast Cancer11
Flavonoids Overcome Drug Resistance to Cancer Chemotherapy by Epigenetically Modulating Multiple Mechanisms11
MiR-129-5p Promotes Radio-sensitivity of NSCLC Cells by Targeting SOX4 and RUNX111
Molecular Dynamics in Esophageal Adenocarcinoma: Who’s in Control?11
Tyrosine Kinase Inhibitors (TKIs) in Lung Cancer Treatment: A Comprehensive Analysis10
Current Treatment and Future Trends of Immunotherapy in Breast Cancer10
mRNA Vaccine - A New Cancer Treatment Strategy9
Paclitaxel Priming of TRAIL Expressing Mesenchymal Stromal Cells (MSCs- TRAIL) Increases Antitumor Efficacy of Their Secretome9
Cross Talk between COVID-19 and Breast Cancer9
β-lapachone: A Promising Anticancer Agent with a Unique NQO1 Specific Apoptosis in Pancreatic Cancer9
The Roles of Alternative Splicing in Tumor-immune Cell Interactions9
Pharmacological Targeting of Ferroptosis in Cancer Treatment9
Molecular Mechanisms of Resistance to Tyrosine Kinase Inhibitors Associated with Hepatocellular Carcinoma9
Advances in Regulating Tumorigenicity and Metastasis of Cancer Through TrkB Signaling9
Systematic Analysis of the Expression Profile and Prognostic Significance of the IGF2BP Family in Lung Adenocarcinoma9
Modulation of Matrix Metalloproteinases by Plant-derived Products9
Targeting Ferroptosis Pathways: A Novel Strategy for Cancer Therapy8
The Role of Oxidative Stress in the Development and Therapeutic Intervention of Hepatocellular Carcinoma8
Clinical Outcomes and Safety of Patients Treated with NAb-Paclitaxel Plus Gemcitabine in Metastatic Pancreatic Cancer: The NAPA Study8
Re-Sensitizing Tumor Cells to Cancer Drugs with Epigenetic Regulators8
Peroxisome Proliferator-activated Receptor Gamma Coactivator-1 Alpha: A Double-edged Sword in Prostate Cancer8
Cucurbitacin D Inhibits the Proliferation of HepG2 Cells and Induces Apoptosis by Modulating JAK/STAT3, PI3K/Akt/mTOR and MAPK Signaling Pathways8
ASPM Predicts Poor Clinical Outcome and Promotes Tumorigenesis for Diffuse Large B-cell Lymphoma8
Oncolytic Adenovirus H101 Synergizes with Radiation in Cervical Cancer Cells8
Metastatic Breast Cancer, Organotropism and Therapeutics: A Review7
New Insights Toward Nanostructured Drug Delivery of Plant-Derived Polyphenol Compounds: Cancer Treatment and Gene Expression Profiles7
Protein Tyrosine Phosphatase 1B (PTP1B): Insights into its New Implications in Tumorigenesis7
Potential Role of miRNA in Metastatic Cascade of Triple-Negative Breast Cancer7
Autophagy in Cancer Cell Transformation: A Potential Novel Therapeutic Strategy7
The Curcumin Analog EF24 is Highly Active Against Chemotherapy- Resistant Melanoma Cells7
DDX39B Predicts Poor Survival and Associated with Clinical Benefit of Anti-PD-L1 Therapy in ccRCC7
Expression and Clinical Significance of SARS-CoV-2 Human Targets in Neoplastic and Non-Neoplastic Lung Tissues7
Anti-cancer Effects of 5-Aminoimidazole-4-Carboxamide-1-β-D-Ribofuranoside (AICAR) on Triple-negative Breast Cancer (TNBC) Cells: Mitochondrial Modulation as an Underlying Mechanism7
LncRNAs as Architects in Cancer Biomarkers with Interface of Epitranscriptomics- Incipient Targets in Cancer Therapy7
Pentamethylquercetin Inhibits Hepatocellular Carcinoma Progression and Adipocytes-induced PD-L1 Expression via IFN-γ Signaling7
Unveiling Novel Therapeutic Drug Targets and Prognostic Markers of Triple Negative Breast Cancer7
Inhibitors and Activators of the p38 Mitogen-Activated MAP Kinase (MAPK) Family as Drugs to Treat Cancer and Inflammation6
Cholangiocarcinoma Therapeutics: An Update6
Preparation of Modified Chitosan-based Nanoparticles for Efficient Delivery of Doxorubicin and/or Cisplatin to Breast Cancer Cells6
Overexpression of RAD50 is the Marker of Poor Prognosis and Drug Resistance in Breast Cancer Patients6
MGMT Epigenetics: The Influence of Gene Body Methylation and Other Insights Derived from Integrated Methylomic, Transcriptomic, and Chromatin Analyses in Various Cancer Types6
Netupitant-palonosetron (NEPA) for Preventing Chemotherapy-induced Nausea and Vomiting: From Clinical Trials to Daily Practice6
Mesenchymal Epithelial Transition (MET): A Key Player in Chemotherapy Resistance and an Emerging Target for Potentiating Cancer Immunotherapy6
Effects of Iron Chelation in Osteosarcoma6
Role of Exosomes in Breast Cancer Management: Evidence-Based Review6
EGF/EGFR Promotes Salivary Adenoid Cystic Carcinoma Cell Malignant Neural Invasion via Activation of PI3K/AKT and MEK/ERK Signaling6
PROTACs: Promising Approaches for Epigenetic Strategies to Overcome Drug Resistance6
ALK-Positive Non-Small Cell Lung Cancer; Potential Combination Drug Treatments6
Spleen Glucose Metabolism on [18F]-FDG PET/CT for Cancer Drug Discovery and Development cannot be Overlooked6
Cancer Vaccine in Cold Tumors: Clinical Landscape, Challenges, and Opportunities6
PBX1 Participates in Estrogen-mediated Bladder Cancer Progression and Chemo-resistance Affecting Estrogen Receptors6
Growth-hormone-releasing Hormone as a Prognostic Biomarker and Therapeutic Target in Gastrointestinal Cancer6
Rediscovering Potential Molecular Targets for Glioma Therapy Through the Analysis of the Cell of Origin, Microenvironment and Metabolism6
Assessing Long Non-coding RNAs in Tobacco-associated Oral Cancer5
Novel MicroRNA Binding Site SNPs and the Risk of Clear Cell Renal Cell Carcinoma (ccRCC): A Case-Control Study5
Role of Aberrant Lipid Metabolism of Cancer Stem Cells in Cancer Progression5
Durable Disease-free Survival in a Patient with Metastatic Triple-negative Breast Cancer Treated with Olaparib Monotherapy5
Dietary Flavonoids with Catechol Moiety Inhibit Anticancer Action of Bortezomib: What about the other Boronic Acid-based Drugs?5
Silencing of FANCI Promotes DNA Damage and Sensitizes Ovarian Cancer Cells to Carboplatin5
Dextran Sulfate Inhibits Angiogenesis and Invasion of Gastric Cancer by Interfering with M2-type Macrophages Polarization5
NONO-TFE3 Fusion Promotes Aerobic Glycolysis and Angiogenesis by Targeting HIF1A in NONO-TFE3 Translocation Renal Cell Carcinoma5
Polyphyllin VII is a Potential Drug Targeting CD44 Positive Colon Cancer Cells5
miRNA as Regulators of Prostate Carcinogenesis and Endocrine and Chemoresistance5
Selective Antitumor Effect of Shikonin Derived DMAKO-20 on Melanoma through CYP1B15
Phosphoserine Aminotransferase 1: A Metabolic Enzyme Target of Cancers5
HIF-1α/Malat1/miR-141 Axis Activates Autophagy to Increase Proliferation, Migration, and Invasion in Triple-negative Breast Cancer5
Immunotherapy: A Potential Approach to Targeting Cancer Stem Cells5
MALAT1 Promotes Tumorigenesis and Increases Cellular Sensitivity to Herceptin in HER2-positive Breast Cancer5
Modulation of ATP8B1 Gene Expression in Colorectal Cancer Cells Suggest its Role as a Tumor Suppressor5
State-of-the-Art: Exosomes in Colorectal Cancer5
Inorganic Phosphate (Pi) in the Breast Cancer Microenvironment: Production, Transport and Signal Transduction as Potential Targets for Anticancer Strategies4
Probiotics as a Therapeutic Approach in Colorectal Cancer4
Targeting the HIF-1α/Cav-1 Pathway with a Chicory Extract/Daidzein Combination Plays a Potential Role in Retarding Hepatocellular Carcinoma4
Progress in Metabolic Studies of Gastric Cancer and Therapeutic Implications4
Combined Inhibition of KIF11 and KIF15 as an Effective Therapeutic Strategy for Gastric Cancer4
The Long Non-coding RNA Cytoskeleton Regulator (CYTOR) Sponges microRNA- 206 (miR-206) to Promote Proliferation and Invasion of HP75 Cells4
Advancement and Strategies for the Development of Peptide-drug Conjugates: Pharmacokinetic Modulation, Role and Clinical Evidence against Cancer Management4
The Efficacy of Vitamin K, A Member Of Naphthoquinones in the Treatment of Cancer: A Systematic Review and Meta-Analysis4
VE-822 Enhanced Cisplatin Chemotherapy Effects on Head and Neck Squamous Cell Carcinoma Drug-resistant Cells4
Biomacromolecule-Functionalized Nanoparticle-Based Conjugates for Potentiation of Anticancer Therapy4
Dysregulated Epigenetics of Chordoma: Prognostic Markers and Therapeutic Targets4
Localized Nano-mediated Interleukin-12 Gene Therapy: Promising Candidate for Cancer Immunotherapeutics4
Drug-Induced Peripheral Neuropathy: Diagnosis and Management4
Neuroinflammation in Glioblastoma: The Role of the Microenvironment in Tumour Progression4
TROP2 Down-regulated DSG2 to Promote Gastric Cancer Cell Invasion and Migration by EGFR/AKT and DSG2/PG/β-Catenin Pathways4
Up-regulation of Core 1 Beta 1, 3-Galactosyltransferase Suppresses Osteosarcoma Growth with Induction of IFN-γ Secretion and Proliferation of CD8+ T Cells4
BCL11A Facilitates Cell Proliferation and Metastasis in Neuroblastoma via Regulating the PI3K/Akt Signaling Pathway4
Receptor Type Protein Tyrosine Phosphatase Epsilon (PTPRE) Plays an Oncogenic Role in Thyroid Carcinoma by Activating the AKT and ERK1/2 Signaling Pathway4
Forkhead-box A3 (FOXA3) Represses Cancer Stemness and Partially Potentiates Chemosensitivity by Targeting Metastasis-Associated in Colon Cancer 1 (MACC1) Signaling Pathway in Colorectal Cancer Cells4
Epigallocatechin-3-gallate Induced HepG2 Cells Apoptosis through ROSmediated AKT /JNK and p53 Signaling Pathway4
The Impacts of Non-coding RNAs and N6-Methyladenosine on Cancer: Past, Present and Future4
Cytotoxicity and Target Modulation in Pediatric Solid Tumors by the Proteasome Inhibitor Carfilzomib4
Protein Arginine Methyltransferases 5 (PRMT5) affect Multiple Stages of Autophagy and Modulate Autophagy-related Genes in Controlling Breast Cancer Tumorigenesis4
Biology, Significance and Immune Signaling of Mucin 1 in Hepatocellular Carcinoma4
HDAC4-mediated Deacetylation of Glutaminase Facilitates Glioma Stemness4
Pharmacological Inhibition of Exosome Machinery: An Emerging Prospect in Cancer Therapeutics4
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