OOIR: Observatory of International Research

Papers

(The TQCC of Current Cancer Drug Targets is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Old and New Approaches to Target the Hsp90 Chaperone	104
Targeting Proliferating Cell Nuclear Antigen (PCNA) as an Effective Strategy to Inhibit Tumor Cell Proliferation	86
Targeting Different Pathways Using Novel Combination Therapy in Triple Negative Breast Cancer	77
COVID-19 Pandemic: Experiences in China and Implications for its Prevention and Treatment Worldwide	31
The Role of RNA Modifications and RNA-modifying Proteins in Cancer Therapy and Drug Resistance	23
Role of Tumor Microenvironment in Cancer Stem Cells Resistance to Radiotherapy	20
Crosstalk of Long Non-coding RNAs and EMT: Searching the Missing Pieces of an Incomplete Puzzle for Lung Cancer Therapy	20
CircRNA SCARB1 Promotes Renal Cell Carcinoma Progression Via Mir- 510-5p/SDC3 Axis	20
Nanotechnology-enabled Chemodynamic Therapy and Immunotherapy	20
The Therapeutic Potential of MAPK/ERK Inhibitors in the Treatment of Colorectal Cancer	20
Protectors of the Mitochondrial Permeability Transition Pore Activated by Iron and Doxorubicin	18
Role of ZEB Family Members in Proliferation, Metastasis, and Chemoresistance of Prostate Cancer Cells: Revealing Signaling Networks	16
Advances in Ovarian Cancer Treatment Beyond PARP Inhibitors	15
C-Myc Signaling Pathway in Treatment and Prevention of Brain Tumors	15
The Potential of Natural Products in the Treatment of Triple-negative Breast Cancer	14
Targeting IDH Mutations in AML: Wielding the Double-edged Sword of Differentiation	14
MUC Glycoproteins: Potential Biomarkers and Molecular Targets for Cancer Therapy	14
Exosome as a Natural Gene Delivery Vector for Cancer Treatment	14
Targeted Drug Therapy to Overcome Chemoresistance in Triple-negative Breast Cancer	13
Overexpression of p62 Induces Autophagy and Promotes Proliferation, Migration and Invasion of Nasopharyngeal Carcinoma Cells through Promoting ERK Signaling Pathway	12
Immune Checkpoint Regulators: A New Era Toward Promising Cancer Therapy	11
Immune Checkpoint Inhibitors in Patients with Recurrent Hepatocellular Carcinoma after Liver Transplantation: A Case Report and Literature Review	11
Tumor Penetrating Peptide-Functionalized Tenascin-C Antibody for Glioblastoma Targeting	11
circEPSTI1 Acts as a ceRNA to Regulate the Progression of Osteosarcoma	11
Recent Progress in Histone Deacetylase (HDAC) 1 Inhibitors as Anticancer Agent	11

Current and Future Therapeutic Targets: A Review on Treating Head and Neck Squamous Cell Carcinoma	11
Lipid-based Nanoplatforms in Cancer Therapy: Recent Advances and Applications	11
Hypermethylation of Single CpG Dinucleotides at the Promoter of CXCL13 Gene Promoting Cell Migration in Cervical Cancer	10
Epigenetic Mechanisms of Therapy Resistance in Diffuse Large B Cell Lymphoma (DLBCL)	10
The Activation of Procarcinogens by CYP1A1/1B1 and Related Chemo-Preventive Agents: A Review	10
HOTAIR Competitively Binds MiRNA330 as a Molecular Sponge to Increase the Resistance of Gastric Cancer to Trastuzumab	10
Antibody-drug Conjugate Targets, Drugs, and Linkers	10
CDK9: Therapeutic Perspective in HCC Therapy	10
Cross Talk between COVID-19 and Breast Cancer	10
Emerging Multi-cancer Regulatory Role of ESRP1: Orchestration of Alternative Splicing to Control EMT	10
FLT3 Inhibition in Acute Myeloid Leukaemia – Current Knowledge and Future Prospects	10
Advances in Regulating Tumorigenicity and Metastasis of Cancer Through TrkB Signaling	9
Paclitaxel Priming of TRAIL Expressing Mesenchymal Stromal Cells (MSCs- TRAIL) Increases Antitumor Efficacy of Their Secretome	9
Flavonoids Overcome Drug Resistance to Cancer Chemotherapy by Epigenetically Modulating Multiple Mechanisms	9
Traditional and Novel Computer-Aided Drug Design (CADD) Approaches in the Anticancer Drug Discovery Process	9
A Molecular Link Between Diabetes and Breast Cancer: Therapeutic Potential of Repurposing Incretin-based Therapies for Breast Cancer	9
Tyrosine Kinase Inhibitors (TKIs) in Lung Cancer Treatment: A Comprehensive Analysis	8
Idronoxil as an Anticancer Agent: Activity and Mechanisms	8
The Evolving AML Genomic Landscape: Therapeutic Implications	8
Molecular Dynamics in Esophageal Adenocarcinoma: Who’s in Control?	8
Cancer Stem Cells with Overexpression of Neuronal Markers Enhance Chemoresistance and Invasion in Retinoblastoma	8
Study of Toll-like Receptor 3 Gene Polymorphism as a Novel Risk Factor for HCV-related Hepatocellular Carcinoma in Egypt	8
Selinexor (KPT-330), an Oral Selective Inhibitor of Nuclear Export (SINE) Compound, in Combination with FOLFOX in Patients with Metastatic Colorectal Cancer (mCRC) - Final Results of the Phase I Trial	8
Molecular Mechanisms of Resistance to Tyrosine Kinase Inhibitors Associated with Hepatocellular Carcinoma	8
The Therapeutic Potential of Urolithin A for Cancer Treatment and Prevention	8
The Roles of Alternative Splicing in Tumor-immune Cell Interactions	8
Oncolytic Adenovirus H101 Synergizes with Radiation in Cervical Cancer Cells	8
Clinical Outcomes and Safety of Patients Treated with NAb-Paclitaxel Plus Gemcitabine in Metastatic Pancreatic Cancer: The NAPA Study	8
MiR-129-5p Promotes Radio-sensitivity of NSCLC Cells by Targeting SOX4 and RUNX1	8
β-lapachone: A Promising Anticancer Agent with a Unique NQO1 Specific Apoptosis in Pancreatic Cancer	8
Cucurbitacin D Inhibits the Proliferation of HepG2 Cells and Induces Apoptosis by Modulating JAK/STAT3, PI3K/Akt/mTOR and MAPK Signaling Pathways	7
ASPM Predicts Poor Clinical Outcome and Promotes Tumorigenesis for Diffuse Large B-cell Lymphoma	7
Peroxisome Proliferator-activated Receptor Gamma Coactivator-1 Alpha: A Double-edged Sword in Prostate Cancer	7
LncRNAs as Architects in Cancer Biomarkers with Interface of Epitranscriptomics- Incipient Targets in Cancer Therapy	7
Unveiling Novel Therapeutic Drug Targets and Prognostic Markers of Triple Negative Breast Cancer	7
Pharmacological Targeting of Ferroptosis in Cancer Treatment	7
Effects of Iron Chelation in Osteosarcoma	7
Rediscovering Potential Molecular Targets for Glioma Therapy Through the Analysis of the Cell of Origin, Microenvironment and Metabolism	6
Metastatic Breast Cancer, Organotropism and Therapeutics: A Review	6
Systematic Analysis of the Expression Profile and Prognostic Significance of the IGF2BP Family in Lung Adenocarcinoma	6
Targeting Ferroptosis Pathways: A Novel Strategy for Cancer Therapy	6
A Review of IGF1 Signaling and IGF1-related Long Noncoding RNAs in Chemoresistance of Cancer	6
Disintegrin Tablysin-15 Suppresses Cancer Hallmarks in Melanoma Cells by Blocking FAK/Akt/ERK and NF-κB Signaling	6
Targeting MUC15 Protein in Cancer: Molecular Mechanisms and Therapeutic Perspectives	6
Novel MicroRNA Binding Site SNPs and the Risk of Clear Cell Renal Cell Carcinoma (ccRCC): A Case-Control Study	6
Expression and Clinical Significance of SARS-CoV-2 Human Targets in Neoplastic and Non-Neoplastic Lung Tissues	6
Re-Sensitizing Tumor Cells to Cancer Drugs with Epigenetic Regulators	6
Inhibitors and Activators of the p38 Mitogen-Activated MAP Kinase (MAPK) Family as Drugs to Treat Cancer and Inflammation	6
Mesenchymal Epithelial Transition (MET): A Key Player in Chemotherapy Resistance and an Emerging Target for Potentiating Cancer Immunotherapy	6
New Insights Toward Nanostructured Drug Delivery of Plant-Derived Polyphenol Compounds: Cancer Treatment and Gene Expression Profiles	6

Modulation of Matrix Metalloproteinases by Plant-derived Products	6
MALAT1 Promotes Tumorigenesis and Increases Cellular Sensitivity to Herceptin in HER2-positive Breast Cancer	5
Role of Exosomes in Breast Cancer Management: Evidence-Based Review	5
Pentamethylquercetin Inhibits Hepatocellular Carcinoma Progression and Adipocytes-induced PD-L1 Expression via IFN-γ Signaling	5
USP48 Sustains Chemoresistance and Metastasis in Ovarian Cancer	5
mRNA Vaccine - A New Cancer Treatment Strategy	5
ALK-Positive Non-Small Cell Lung Cancer; Potential Combination Drug Treatments	5
Fas Ligand Enhances Apoptosis of Human Lung Cancer Cells Cotreated with RIG-I-like Receptor Agonist and Radiation	5
The Curcumin Analog EF24 is Highly Active Against Chemotherapy- Resistant Melanoma Cells	5
PBX1 Participates in Estrogen-mediated Bladder Cancer Progression and Chemo-resistance Affecting Estrogen Receptors	5
Current Treatment and Future Trends of Immunotherapy in Breast Cancer	5
Potential Role of miRNA in Metastatic Cascade of Triple-Negative Breast Cancer	5
Assessing Long Non-coding RNAs in Tobacco-associated Oral Cancer	5
Novel Homeodomain Transcription Factor Nkx2.2 in the Brain Tumor Development	5
Cholangiocarcinoma Therapeutics: An Update	5
Spleen Glucose Metabolism on [18F]-FDG PET/CT for Cancer Drug Discovery and Development cannot be Overlooked	5
Modulation of ATP8B1 Gene Expression in Colorectal Cancer Cells Suggest its Role as a Tumor Suppressor	5
Resistance of Lenvatinib in Hepatocellular Carcinoma	5
PROTACs: Promising Approaches for Epigenetic Strategies to Overcome Drug Resistance	5
HIF-1α/Malat1/miR-141 Axis Activates Autophagy to Increase Proliferation, Migration, and Invasion in Triple-negative Breast Cancer	5
Updated Review and Perspective on 20S Proteasome Inhibitors in the Treatment of Lung Cancer	5
Preparation of Modified Chitosan-based Nanoparticles for Efficient Delivery of Doxorubicin and/or Cisplatin to Breast Cancer Cells	5