OOIR: Observatory of International Research

Papers

(The TQCC of Mitochondrion is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
The role of mtDNA haplogroups on metabolic features in narcolepsy type 1	137
Mitochondrial DNA mutations do not impact early human embryonic development	131
The tissue-specific nature of physiological zebrafish mitochondrial bioenergetics	129
CMT2A-linked MFN2 mutation, T206I promotes mitochondrial hyperfusion and predisposes cells towards mitophagy	91
Hsp90 and its mitochondrial homologue TRAP-1 independently regulate hypoxia adaptations in Caenorhabditis elegans	58
Mitochondrial calcium signaling in the brain and its modulation by neurotropic viruses	57
The multifaceted modulation of mitochondrial metabolism in tumorigenesis	49
Sequencing errors in Native American mitogenomes: Impact on clade definitions, haplogroup assignation, and beyond	49
Editorial Board	48
Endoplasmic reticulum & mitochondrial calcium homeostasis: The interplay with viruses	48
Comparison of whole genome sequencing and targeted sequencing for mitochondrial DNA	46
What can we do to optimize mitochondrial transplantation therapy for myocardial ischemia–reperfusion injury?	45
Mitofusin 2: The missing link between mtDNA maintenance defects and neurotransmitter disorders	43
Activation of multifunctional DNA repair APE1/Ref-1 enzyme by the dietary phytochemical Ferulic acid protects human neuroblastoma SH-SY5Y cells against Aβ(25–35)-induced oxidative stress and inflammat	38
Mrs2-mediated mitochondrial magnesium uptake is essential for the regulation of MCU-mediated mitochondrial Ca2+ uptake and viability	37
ACAD9 treatment with bezafibrate and nicotinamide riboside temporarily stabilizes cardiomyopathy and lactic acidosis	37
Delivery of mitoceuticals or respiratory competent mitochondria to sites of neurotrauma	37
The mitochondrial-derived peptide MOTS-c promotes homeostasis in aged human placenta-derived mesenchymal stem cells in vitro	35
Role of GM-CSF in regulating metabolism and mitochondrial functions critical to macrophage proliferation	33
Mitophagy in depression: Pathophysiology and treatment targets	31
Editorial Board	31
Targeting the redox imbalance in mitochondria: A novel mode for cancer therapy	31
Thyroid hormone enhances efficacy of cisplatin in lung cancer patients via down-regulating GLUT1 expression and reversing the Warburg effect	30
Mitochondrial density in skeletal and cardiac muscle	30
PhNR and peripapillary RNFL changes in Leber hereditary optic neuropathy with m.G11778A mutation	30

The role of mitochondrial genes in ischemia-reperfusion injury: A systematic review of experimental studies	30
Editorial Board	30
Paternal aging impacts mitochondrial DNA content and telomere length in mouse embryos	29
Reanalysis of mtDNA mutations of human primordial germ cells (PGCs) reveals NUMT contamination and suggests that selection in PGCs may be positive	28
The war against Alzheimer, the mitochondrion strikes back!	28
Editorial Board	27
Mitochondria in biology and medicine – 2023	27
Pyridoxal-5-phosphate mitigates age-related metabolic imbalances in the rat heart through the H2S/AKT/GSK3β signaling axis	25
Reactive oxygen species favors Varicellovirus bovinealpha 5 (BoAHV-5) replication in neural cells	24
Site-specific mitochondrial dysfunction in neurodegeneration	23
Mitochondrial genome-derived circRNAs: Orphan epigenetic regulators in molecular biology	23
Genomic and non-genomic action of vitamin D on ion channels – Targeting mitochondria	23
Ethylmalonic encephalopathy ETHE1 p. D165H mutation alters the mitochondrial function in human skeletal muscle proteome	22
Identification of a novel m.3955G > A variant in MT-ND1 associated with Leigh syndrome	22
Reviving mitochondrial bioenergetics: A relevant approach in epilepsy	21
Mitochondrion-driven nephroprotective mechanisms of novel glucose lowering medications	21
TRPV4 acts as a mitochondrial Ca2+-importer and regulates mitochondrial temperature and metabolism	20
Muscle-UCP3 in the regulation of energy metabolism	20
Extracellular mitochondria in the cerebrospinal fluid (CSF): Potential types and key roles in central nervous system (CNS) physiology and pathogenesis	20
Exploring the role of mitochondria transfer/transplant and their long-non-coding RNAs in regenerative therapies for skin aging	19
Mitochondrial Irc3 helicase of the thermotolerant yeast Ogataea polymorpha displays dual DNA- and RNA-stimulated ATPase activity	19
Circumventing the Crabtree effect in cell culture: A systematic review	19
Decoding the nature and complexity of extracellular mtDNA: Types and implications for health and disease	18
Impact of missense mutations on the structure–function relationship of human succinyl-CoA synthetase using in silico analysis	18
Mitochondrial transplantation therapy inhibits the proliferation of malignant hepatocellular carcinoma and its mechanism	18
COVID-19 induced liver injury from a new perspective: Mitochondria	18
Blood cell respiration rates and mtDNA copy number: A promising tool for the diagnosis of mitochondrial disease	18
Reviewing the mitochondrial dysfunction paradigm in rodent models as platforms for neuropsychiatric disease research	18
Advancing mitochondria as a therapeutic agent	17
Understanding differential aspects of microdiffusion (channeling) in the Coenzyme Q and Cytochrome c regions of the mitochondrial respiratory system	17
The maternal genetic history of tribal populations of Chhattisgarh, India	17
Association analysis of mitochondrial DNA heteroplasmic variants: Methods and application	16
Mitochondrial oxidative stress in brain microvascular endothelial cells: Triggering blood-brain barrier disruption	16
Serum TCA cycle metabolites in Lewy bodies dementia and Alzheimer's disease: Network analysis and cognitive prognosis	16
2-Aminoethoxydiphenyl borate ameliorates mitochondrial dysfunctions in MPTP/MPP+ model of Parkinson’s disease	16
Interplay of mitochondria and diabetes: Unveiling novel therapeutic strategies	16
Mitochondria dysfunction and impaired response to oxidative stress promotes proteostasis disruption in aged human cells	16
Metabolic abnormality in acute stroke-like lesion and its relationship with focal cerebral blood flow in patients with MELAS: Evidence from proton MR spectroscopy and arterial spin labeling	15
Prognostic value of circulating mitochondrial DNA in prostate cancer and underlying mechanism	15
The biology of mitochondrial carrier homolog 2	15
Mitochondrial dysfunction and inflammasome activation in neurodegenerative diseases: Mechanisms and therapeutic implications	15
Whole genome sequencing followed by functional analysis of genomic deletion encompassing ERCC8 and NDUFAF2 genes in a non-consanguineous Indian family reveals dysfunctional mitochondrial bioenergetics	15
Application research of novel peptide mitochondrial-targeted antioxidant SS-31 in mitigating mitochondrial dysfunction	15
An integrated multi-omics approach allowed ultra-rapid diagnosis of a deep intronic pathogenic variant in PDHX and precision treatment in a neonate critically ill with lactic acidosis	15
Editorial Board	15
Neuroprotective compounds alter the expression of genes coding for proteins related to mitochondrial function in activated microglia	15
Newer mitochondrial dynamics and their role of calcium signalling in liver regeneration	15
Corrigendum to “Comparison of whole genome sequencing and targeted sequencing for mitochondrial DNA” [Mitochondrion 58 (2021) 303–310]	15
Stressed mitochondria: A target to intrude alzheimer’s disease	14
Mitochondrial bioenergetics of breast cancer	14

Targeting mitochondria with small molecules: A promising strategy for combating Parkinson’s disease	14
RTN3 deficiency exacerbates cisplatin-induced acute kidney injury through the disruption of mitochondrial stability	14
HERMES: An improved method to test mitochondrial genome molecular synapomorphies among clades	14
Visualization of mitophagy using LysoKK, a 7-nitro-2,1,3-benzoxadiazole-(arylpropyl)benzylamine derivative	14
Mitochondrial N-methyl-d-aspartate receptor activation enhances bioenergetics by calcium-dependent and –Independent mechanisms	14
Polysulfide inhibits hypoxia-elicited hypoxia-inducible factor activation in a mitochondria-dependent manner	14
Miro1 improves the exogenous engraftment efficiency and therapeutic potential of mitochondria transfer using Wharton's jelly mesenchymal stem cells	14
Research progress on paternal mitochondrial inheritance: An overview	14
The Parkinson’s disease-associated mutation LRRK2 G2385R alters mitochondrial biogenesis via the PGC-1α-TFAM pathway	13
Fighting Parkinson’s disease: The return of the mitochondria	13
Targeting the mitochondria in chronic respiratory diseases	13
Defining ER-mitochondria contact dynamics in Plasmodium falciparum by targeting component of phospholipid synthesis pathway, phosphatidylserine synthase (PfPSS)	13
Selective and reversible disruption of mitochondrial inner membrane protein complexes by lipophilic cations	13
Editorial Board	12
Type 1 diabetes mellitus: Inflammation, mitophagy, and mitochondrial function	12
Cancer/Testis Antigen 55 is required for cancer cell proliferation and mitochondrial DNA maintenance	12
Severe acute respiratory syndrome coronaviruses contributing to mitochondrial dysfunction: Implications for post-COVID complications	12
WITHDRAWN: Mitochondrial oxygen respiration is associated with loneliness in a sample of community-dwelling adults	12
Comparative mitogenomics of Agaricomycetes: Diversity, abundance, impact and coding potential of putative open-reading frames	12
Receptor-mediated mitophagy: An emerging therapeutic target in acute kidney injury	11
Ancestry affects the transcription of small mitochondrial RNAs in human lymphocytes	11
Differentiation activates mitochondrial OPA1 processing in myoblast cell lines	11
Transplantation of astrocyte-derived mitochondria into injured astrocytes has a protective effect following stretch injury	11
Mitochondrial dysfunction and skeletal muscle atrophy: Causes, mechanisms, and treatment strategies	11
Altered brown adipose tissue mitochondrial function in newborn fragile X syndrome mice	11
Aromatic hydrocarbon receptors in mitochondrial biogenesis and function	11
Crystallographic modeling of the PNPT1:c.1453A>G variant as a cause of mitochondrial dysfunction and autosomal recessive deafness; expanding the neuroimaging and clinical features	11
Role of mitophagy in pulmonary hypertension: Targeting the mechanism and pharmacological intervention	11
Longitudinal changes in mitochondrial-associated measures and insulin resistance in youth with perinatally-acquired HIV in the U.S	11
Early cardiac mechanics abnormalities in patients with mitochondrial diseases	11