OOIR: Observatory of International Research

Papers

(The TQCC of Mitochondrion is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Mitochondria and microbiota dysfunction in COVID-19 pathogenesis	232
Thinking outside the nucleus: Mitochondrial DNA copy number in health and disease	184
Photosynthesis, respiration and growth: A carbon and energy balancing act for alternative oxidase	80
Stress and circulating cell-free mitochondrial DNA: A systematic review of human studies, physiological considerations, and technical recommendations	78
The Oxidative Phosphorylation system of the mitochondria in plants	75
Blood mitochondrial DNA copy number: What are we counting?	75
Complex IV – The regulatory center of mitochondrial oxidative phosphorylation	74
Mitochondria, spermatogenesis, and male infertility – An update	71
Variation in protein gene and intron content among land plant mitogenomes	63
Mitochondrial pathways in human health and aging	47
Mitochondrial unfolded protein-related responses across kingdoms: similar problems, different regulators	43
Mitochondrial dysfunction: An emerging link in the pathophysiology of polycystic ovary syndrome	43
Mitochondrial miRNAs (MitomiRs): Their potential roles in breast and other cancers	40
Mitochondrial dysfunction as a mechanistic biomarker in patients with non-alcoholic fatty liver disease (NAFLD)	40
Structural and functional properties of plant mitochondrial F-ATP synthase	37
Reviving mitochondrial bioenergetics: A relevant approach in epilepsy	36
Characterization and origins of cell-free mitochondria in healthy murine and human blood	36
Mitochondrial dysfunction in schizophrenia: With a focus on postmortem studies	35
Mitochondrial abnormalities in neurodegenerative models and possible interventions: Focus on Alzheimer’s disease, Parkinson’s disease, Huntington’s disease	34
Interchangeable parts: The evolutionarily dynamic tRNA population in plant mitochondria	31
Stressed mitochondria: A target to intrude alzheimer’s disease	30
Mitochondria and early-life adversity	29
Detection of mitochondria-pertinent components in exosomes	29
Severe life stress, mitochondrial dysfunction, and depressive behavior: A pathophysiological and therapeutic perspective	28
Mitochondria in parasitic plants	27

Citrate valve integrates mitochondria into photosynthetic metabolism	27
The diversity and coexistence of extracellular mitochondria in circulation: A friend or foe of the immune system	26
Mitochondrial dysfunction as a critical event in the pathophysiology of bipolar disorder	26
Mitochondrial uncoupling protein-dependent signaling in plant bioenergetics and stress response	26
The existence and function of mitochondrial component in extracellular vesicles	26
Miro (Mitochondrial Rho GTPase), a key player of mitochondrial axonal transport and mitochondrial dynamics in neurodegenerative diseases	25
Molecular mechanism of mitochondrial respiratory chain assembly and its relation to mitochondrial diseases	25
The role of mitochondrial-related nuclear genes in age-related common disease	25
Role of GM-CSF in regulating metabolism and mitochondrial functions critical to macrophage proliferation	25
The role of mitophagy in pulmonary sepsis	25
Targeting the redox imbalance in mitochondria: A novel mode for cancer therapy	24
Molecular machinery regulating mitochondrial calcium levels: The nuts and bolts of mitochondrial calcium dynamics	24
Distinguishing mitochondrial DNA and NUMT sequences amplified with the precision ID mtDNA whole genome panel	24
Mitophagy in depression: Pathophysiology and treatment targets	24
Mitochondrial transplantation for organ rescue	24
Mitochondria determine response to anti-programmed cell death protein-1 (anti-PD-1) immunotherapy: An evidence-based hypothesis	24
Mitochondrial calcium at the synapse	23
Extracellular mitochondria in the cerebrospinal fluid (CSF): Potential types and key roles in central nervous system (CNS) physiology and pathogenesis	22
Mitochondria transfer and transplantation in human health and diseases	22
Yoga improves mitochondrial health and reduces severity of autoimmune inflammatory arthritis: A randomized controlled trial	22
Blood biomarkers for assessment of mitochondrial dysfunction: An expert review	22
Mitochondrial tRNA mutations in 887 Chinese subjects with hearing loss	21
Simulated microgravity triggers DNA damage and mitochondria-mediated apoptosis through ROS generation in human promyelocytic leukemic cells	21
Chronic treatment with dapagliflozin protects against mitochondrial dysfunction in the liver of C57BL/6NCrl mice with high-fat diet/streptozotocin-induced diabetes mellitus	21
Platelet mtDNA content and leukocyte count influence whole blood mtDNA content	21
Modulation of host mitochondrial dynamics during bacterial infection	21
The use of a MITO-Porter to deliver exogenous therapeutic RNA to a mitochondrial disease’s cell with a A1555G mutation in the mitochondrial 12S rRNA gene results in an increase in mitochondrial respir	20
Targeting the mitochondria in chronic respiratory diseases	20
Mitochondrial NAD(P)H oxidation pathways and nitrate/ammonium redox balancing in plants	19
Altered mitochondrial calcium handling and cell death by necroptosis: An emerging paradigm	19
Endoplasmic reticulum & mitochondrial calcium homeostasis: The interplay with viruses	19
A hitchhiker’s guide to mitochondrial quantification	19
Fighting Parkinson’s disease: The return of the mitochondria	19
qMGR: A new approach for quantifying mitochondrial genome rearrangement	19
PGC1A driven enhanced mitochondrial DNA copy number predicts outcome in pediatric acute myeloid leukemia	19
Mitochondrial-associated impairments of temozolomide on neural stem/progenitor cells and hippocampal neurons	18
Mitochondrial chaperone, TRAP1 modulates mitochondrial dynamics and promotes tumor metastasis	18
Protective effects of a small molecule inhibitor, DDQ against amyloid beta in Alzheimer’s disease	18
Targeting the mitochondrial permeability transition pore for drug discovery: Challenges and opportunities	17
Abnormal lncRNA CCAT1/microRNA-155/SIRT1 axis promoted inflammatory response and apoptosis of tubular epithelial cells in LPS caused acute kidney injury	17
Energy metabolism and oxidative status of rat liver mitochondria in conditions of experimentally induced hyperthyroidism	17
Protective effects of a mitochondria-targeted small peptide SS31 against hyperglycemia-induced mitochondrial abnormalities in the liver tissues of diabetic mice, Tallyho/JngJ mice	16
The ERMES (Endoplasmic Reticulum and Mitochondria Encounter Structures) mediated functions in fungi	16
Mitophagy impairment in neurodegenerative diseases: Pathogenesis and therapeutic interventions	16
The roles of assembly factors in mammalian mitoribosome biogenesis	16
Characterization of background noise in MiSeq MPS data when sequencing human mitochondrial DNA from various sample sources and library preparation methods	16
Exploring the role of mitochondrial proteins as molecular target in Alzheimer’s disease	15
Mitochondrial repair as potential pharmacological target in cerebral ischemia	15
Evaluation of anticancer role of a novel ruthenium(II)-based compound compared with NAMI-A and cisplatin in impairing mitochondrial functionality and promoting oxidative stress in triple negative brea	15
Alzheimer’s and Parkinson’s brain tissues have reduced expression of genes for mtDNA OXPHOS Proteins, mitobiogenesis regulator PGC-1α protein and mtRNA stabilizing protein LRPPRC (LRP130)	15

Mitochondrial dysfunction and oxidative stress in Alzheimer’s disease, and Parkinson’s disease, Huntington’s disease and Amyotrophic Lateral Sclerosis -An updated review	15
Development of a nanoparticle that releases nucleic acids in response to a mitochondrial environment	15
The contribution of uncoupling protein 2 to mitochondrial Ca2+ homeostasis in health and disease – A short revisit	14
Mitochondrial dynamics keep balance of nutrient combustion in thermogenic adipocytes	14
Mitochondrial migraine; a prevalence, impact and treatment efficacy cohort study	14
Prospects of mitochondrial transplantation in clinical medicine: Aspirations and challenges	14
The nuclear factor kappa B (NF-κB) signaling pathway is involved in ammonia-induced mitochondrial dysfunction	14
Combination therapy with astaxanthin and epidermal neural crest stem cells improves motor impairments and activates mitochondrial biogenesis in a rat model of spinal cord injury	14
Melatonin protects against excessive autophagy-induced mitochondrial and ovarian reserve function deficiency though ERK signaling pathway in Chinese hamster ovary (CHO) cells	13
Alpha lipoic acid and vitamin E improve atorvastatin-induced mitochondrial dysfunctions in rats	13
Complex I protein NDUFS2 is vital for growth, ROS generation, membrane integrity, apoptosis, and mitochondrial energetics	13
Effects of dietary iron restriction on kidney mitochondria function and oxidative stress in streptozotocin-diabetic rats	13
How hot can mitochondria be? Incubation at temperatures above 43 °C induces the degradation of respiratory complexes and supercomplexes in intact cells and isolated mitochondria	13
Laurus nobilis ethanolic extract attenuates hyperglycemia and hyperinsulinemia-induced insulin resistance in HepG2 cell line through the reduction of oxidative stress and improvement of mitochondrial	13
Coxfa4l3, a novel mitochondrial electron transport chain Complex 4 subunit protein, switches from Coxfa4 during spermatogenesis	13
MicroRNA-338 inhibition protects against focal cerebral ischemia and preserves mitochondrial function in vitro in astrocytes and neurons via COX4I1	13
Mitochondrion-driven nephroprotective mechanisms of novel glucose lowering medications	13
Mitochondrial neuropathy and neurogenic features in mitochondrial myopathy	13
Whole exome sequencing identifies a novel homozygous MECR mutation in a Chinese patient with childhood-onset dystonia and basal ganglia abnormalities, without optic atrophy	13
Sirtuin 3 and mitochondrial permeability transition pore (mPTP): A systematic review	12
Chemical acetylation of mitochondrial transcription factor A occurs on specific lysine residues and affects its ability to change global DNA topology	12
Molecular docking and simulation studies of phytocompounds derived from Centella asiatica and Andrographis paniculata against hexokinase II as mitocan agents	12
Diagnostic value of circulating cell-free mtDNA in patients with suspected thyroid cancer: ND4/ND1 ratio as a new potential plasma marker	12
Circumventing the Crabtree effect in cell culture: A systematic review	12
Altered insulin pathway compromises mitochondrial function and quality control both in in vitro and in vivo model systems	12
Mitochondrial oxidative stress in brain microvascular endothelial cells: Triggering blood-brain barrier disruption	12
Prothymosin α promotes colorectal carcinoma chemoresistance through inducing lipid droplet accumulation	12
Mitochondrial metabolism and calcium homeostasis in the development of NAFLD leading to hepatocellular carcinoma	12
Placental mitochondrial DNA mutations and copy numbers in intrauterine growth restricted (IUGR) pregnancy	12
ATM mediated-p53 signaling pathway forms a novel axis for senescence control	12
TRPV4 acts as a mitochondrial Ca2+-importer and regulates mitochondrial temperature and metabolism	11
Altered mitochondrial proteome and functional dynamics in patients with rheumatoid arthritis	11
Low mitochondrial DNA copy number is associated with poor prognosis and treatment resistance in glioblastoma	11
Metabolic abnormality in acute stroke-like lesion and its relationship with focal cerebral blood flow in patients with MELAS: Evidence from proton MR spectroscopy and arterial spin labeling	11
Mitochondrial dysfunction and traffic jams in amyotrophic lateral sclerosis	11
Trapped topoisomerase-DNA covalent complexes in the mitochondria and their role in human diseases	11
Protein turnover rates in plant mitochondria	11
Intricate role of mitochondrial calcium signalling in mitochondrial quality control for regulation of cancer cell fate	11
Mitochondria-targeted antioxidant, mito-TEMPO mitigates initiation phase of N-Nitrosodiethylamine-induced hepatocarcinogenesis	11
Site-specific mitochondrial dysfunction in neurodegeneration	11
The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat	11
Leber’s hereditary optic neuropathy: Current approaches and future perspectives on Mesenchymal stem cell-mediated rescue	11