OOIR: Observatory of International Research

Papers

(The TQCC of Mitochondrion is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Blood mitochondrial DNA copy number: What are we counting?	103
Stress and circulating cell-free mitochondrial DNA: A systematic review of human studies, physiological considerations, and technical recommendations	96
Complex IV – The regulatory center of mitochondrial oxidative phosphorylation	92
Mitochondrial dysfunction and oxidative stress in Alzheimer’s disease, and Parkinson’s disease, Huntington’s disease and Amyotrophic Lateral Sclerosis -An updated review	49
Mitochondrial dysfunction as a mechanistic biomarker in patients with non-alcoholic fatty liver disease (NAFLD)	48
Mitochondrial dysfunction in schizophrenia: With a focus on postmortem studies	46
Mitochondrial miRNAs (MitomiRs): Their potential roles in breast and other cancers	45
Detection of mitochondria-pertinent components in exosomes	41
Reviving mitochondrial bioenergetics: A relevant approach in epilepsy	40
Mitochondrial abnormalities in neurodegenerative models and possible interventions: Focus on Alzheimer’s disease, Parkinson’s disease, Huntington’s disease	38
Mitochondrial transplantation for organ rescue	35
The role of mitophagy in pulmonary sepsis	35
Mitochondria and early-life adversity	33
Stressed mitochondria: A target to intrude alzheimer’s disease	33
Mitochondrial calcium at the synapse	32
Severe life stress, mitochondrial dysfunction, and depressive behavior: A pathophysiological and therapeutic perspective	32
Mitochondria transfer and transplantation in human health and diseases	31
Simulated microgravity triggers DNA damage and mitochondria-mediated apoptosis through ROS generation in human promyelocytic leukemic cells	30
Blood biomarkers for assessment of mitochondrial dysfunction: An expert review	30
Miro (Mitochondrial Rho GTPase), a key player of mitochondrial axonal transport and mitochondrial dynamics in neurodegenerative diseases	29
Mitochondrial dysfunction as a critical event in the pathophysiology of bipolar disorder	29
Role of GM-CSF in regulating metabolism and mitochondrial functions critical to macrophage proliferation	28
Yoga improves mitochondrial health and reduces severity of autoimmune inflammatory arthritis: A randomized controlled trial	28
Molecular machinery regulating mitochondrial calcium levels: The nuts and bolts of mitochondrial calcium dynamics	28
Mitophagy in depression: Pathophysiology and treatment targets	28

The diversity and coexistence of extracellular mitochondria in circulation: A friend or foe of the immune system	27
Targeting the mitochondria in chronic respiratory diseases	26
Distinguishing mitochondrial DNA and NUMT sequences amplified with the precision ID mtDNA whole genome panel	26
Fighting Parkinson’s disease: The return of the mitochondria	26
A hitchhiker’s guide to mitochondrial quantification	26
Targeting the redox imbalance in mitochondria: A novel mode for cancer therapy	25
Targeting the mitochondrial permeability transition pore for drug discovery: Challenges and opportunities	25
Extracellular mitochondria in the cerebrospinal fluid (CSF): Potential types and key roles in central nervous system (CNS) physiology and pathogenesis	24
Mitochondria determine response to anti-programmed cell death protein-1 (anti-PD-1) immunotherapy: An evidence-based hypothesis	24
Chronic treatment with dapagliflozin protects against mitochondrial dysfunction in the liver of C57BL/6NCrl mice with high-fat diet/streptozotocin-induced diabetes mellitus	24
PGC1A driven enhanced mitochondrial DNA copy number predicts outcome in pediatric acute myeloid leukemia	23
The use of a MITO-Porter to deliver exogenous therapeutic RNA to a mitochondrial disease’s cell with a A1555G mutation in the mitochondrial 12S rRNA gene results in an increase in mitochondrial respir	23
Endoplasmic reticulum & mitochondrial calcium homeostasis: The interplay with viruses	23
The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat	23
Altered mitochondrial calcium handling and cell death by necroptosis: An emerging paradigm	21
Mitochondrial repair as potential pharmacological target in cerebral ischemia	21
How hot can mitochondria be? Incubation at temperatures above 43 °C induces the degradation of respiratory complexes and supercomplexes in intact cells and isolated mitochondria	20
The roles of assembly factors in mammalian mitoribosome biogenesis	20
Protective effects of a small molecule inhibitor, DDQ against amyloid beta in Alzheimer’s disease	20
Protective effects of a mitochondria-targeted small peptide SS31 against hyperglycemia-induced mitochondrial abnormalities in the liver tissues of diabetic mice, Tallyho/JngJ mice	18
Mitochondrial dysfunction and skeletal muscle atrophy: Causes, mechanisms, and treatment strategies	18
The nuclear factor kappa B (NF-κB) signaling pathway is involved in ammonia-induced mitochondrial dysfunction	18
Laurus nobilis ethanolic extract attenuates hyperglycemia and hyperinsulinemia-induced insulin resistance in HepG2 cell line through the reduction of oxidative stress and improvement of mitochondrial	17
Prospects of mitochondrial transplantation in clinical medicine: Aspirations and challenges	17
Erodible thermogelling hydrogels for localized mitochondrial transplantation to the spinal cord	17
Mitochondrial oxidative stress in brain microvascular endothelial cells: Triggering blood-brain barrier disruption	17
Melatonin protects against excessive autophagy-induced mitochondrial and ovarian reserve function deficiency though ERK signaling pathway in Chinese hamster ovary (CHO) cells	17
Receptor-mediated mitophagy: An emerging therapeutic target in acute kidney injury	17
Placental mitochondrial DNA mutations and copy numbers in intrauterine growth restricted (IUGR) pregnancy	17
Mitophagy impairment in neurodegenerative diseases: Pathogenesis and therapeutic interventions	17
Mitochondrial dynamics keep balance of nutrient combustion in thermogenic adipocytes	17
Complex I protein NDUFS2 is vital for growth, ROS generation, membrane integrity, apoptosis, and mitochondrial energetics	17
Exploring the role of mitochondrial proteins as molecular target in Alzheimer’s disease	17
Evaluation of anticancer role of a novel ruthenium(II)-based compound compared with NAMI-A and cisplatin in impairing mitochondrial functionality and promoting oxidative stress in triple negative brea	16
TRPV4 acts as a mitochondrial Ca2+-importer and regulates mitochondrial temperature and metabolism	15
The contribution of uncoupling protein 2 to mitochondrial Ca2+ homeostasis in health and disease – A short revisit	15
Mitochondria-targeted antioxidant, mito-TEMPO mitigates initiation phase of N-Nitrosodiethylamine-induced hepatocarcinogenesis	14
Sirtuin 3 and mitochondrial permeability transition pore (mPTP): A systematic review	14
Mitochondrial calcium in command of juggling myriads of cellular functions	14
Mitochondrial dysfunction and traffic jams in amyotrophic lateral sclerosis	14
Trapped topoisomerase-DNA covalent complexes in the mitochondria and their role in human diseases	14
Molecular docking and simulation studies of phytocompounds derived from Centella asiatica and Andrographis paniculata against hexokinase II as mitocan agents	14
Mitochondrial neuropathy and neurogenic features in mitochondrial myopathy	14
Circumventing the Crabtree effect in cell culture: A systematic review	14
Mitochondria-targeting therapeutic strategies in the treatment of depression	13
Mitochondrion-driven nephroprotective mechanisms of novel glucose lowering medications	13
MicroRNA-338 inhibition protects against focal cerebral ischemia and preserves mitochondrial function in vitro in astrocytes and neurons via COX4I1	13
Mitochondrial dynamics related neurovascular approaches in cerebral ischemic injury	13
Standpoints in mitochondrial dysfunction: Underlying mechanisms in search of therapeutic strategies	13
Site-specific mitochondrial dysfunction in neurodegeneration	13

Whole exome sequencing identifies a novel homozygous MECR mutation in a Chinese patient with childhood-onset dystonia and basal ganglia abnormalities, without optic atrophy	13
Diagnostic value of circulating cell-free mtDNA in patients with suspected thyroid cancer: ND4/ND1 ratio as a new potential plasma marker	12
The mitochondrial-derived peptide MOTS-c promotes homeostasis in aged human placenta-derived mesenchymal stem cells in vitro	12
Low mitochondrial DNA copy number is associated with poor prognosis and treatment resistance in glioblastoma	12
Leber’s hereditary optic neuropathy: Current approaches and future perspectives on Mesenchymal stem cell-mediated rescue	12
ATM mediated-p53 signaling pathway forms a novel axis for senescence control	12
Mitochondrial metabolism and calcium homeostasis in the development of NAFLD leading to hepatocellular carcinoma	12
The war against Alzheimer, the mitochondrion strikes back!	12
Comparison of whole genome sequencing and targeted sequencing for mitochondrial DNA	12
Metabolic abnormality in acute stroke-like lesion and its relationship with focal cerebral blood flow in patients with MELAS: Evidence from proton MR spectroscopy and arterial spin labeling	12
Mitochondria dysfunction and impaired response to oxidative stress promotes proteostasis disruption in aged human cells	12
Prothymosin α promotes colorectal carcinoma chemoresistance through inducing lipid droplet accumulation	12
Comparative mitogenomics of Agaricomycetes: Diversity, abundance, impact and coding potential of putative open-reading frames	12
Mycobacterial origin protein Rv0674 localizes into mitochondria, interacts with D-loop and regulates OXPHOS for intracellular persistence of Mycobacterium tuberculosis	12
Altered insulin pathway compromises mitochondrial function and quality control both in in vitro and in vivo model systems	12
Characterization of the interactome of c-Src within the mitochondrial matrix by proximity-dependent biotin identification	11
Repeated mild traumatic brain injuries perturb the mitochondrial biogenesis via DNA methylation in the hippocampus of rat	11
In vitro models of insulin resistance: Mitochondrial coupling is differently affected in liver and muscle cells	11
Alterations in inter-organelle crosstalk and Ca2+ signaling through mitochondria during proteotoxic stresses	11
Differential effects of 808-nm light on electron transport chain enzymes in isolated mitochondria: Implications for photobiomodulation initiation	11
Intricate role of mitochondrial calcium signalling in mitochondrial quality control for regulation of cancer cell fate	11
Mitochondrial transplantation therapy inhibits the proliferation of malignant hepatocellular carcinoma and its mechanism	10
Mitochondrial dysfunction in cognitive neurodevelopmental disorders: Cause or effect?	10
Micronutrients/miRs/ATP networking in mitochondria: Clinical intervention with ferroptosis, cuproptosis, and calcium burden	10
Recent trends of natural based therapeutics for mitochondria targeting in Alzheimer’s disease	10
Mitohormesis; Potential implications in neurodegenerative diseases	10
Mitochondrial protein phosphorylation in yeast revisited	10
Long read mitochondrial genome sequencing using Cas9-guided adaptor ligation	10
Understanding the neuronal synapse and challenges associated with the mitochondrial dysfunction in mild cognitive impairment and Alzheimer’s disease	10
Mitochondrial DNA maintenance disorders in 102 patients from different parts of Russia: Mutational spectrum and phenotypes	10
Hypoxia-induced mitochondrial reactive oxygen species (mtROS) differentially regulates smooth muscle cell (SMC) proliferation of pulmonary and systemic vasculature	10
Serum fibroblast growth factor 21 and growth differentiation factor 15: Two sensitive biomarkers in the diagnosis of mitochondrial disorders	10
Exploring the role of mitochondria transfer/transplant and their long-non-coding RNAs in regenerative therapies for skin aging	9
Severe acute respiratory syndrome coronaviruses contributing to mitochondrial dysfunction: Implications for post-COVID complications	9
Selective and reversible disruption of mitochondrial inner membrane protein complexes by lipophilic cations	9
A mitochondrial myopathy-associated tRNASer(UCN) 7453G>A mutation alters tRNA metabolism and mitochondrial function	9
Mitochondrial ribosomal protein genes connected with Alzheimer’s and tellurite toxicity	9
Delivery of mitoceuticals or respiratory competent mitochondria to sites of neurotrauma	9
Mitochondrial iron-sulfur cluster biogenesis and neurological disorders	9
ATPAF1 deficiency impairs ATP synthase assembly and mitochondrial respiration	9
Mitofusin 2: A link between mitochondrial function and substrate metabolism?	9
MicroRNA-128 inhibits mitochondrial biogenesis and function via targeting PGC1α and NDUFS4	9
Traumatic brain injury metabolome and mitochondrial impact after early stage Ru360 treatment	9
Placental mitochondrial DNA mutational load and perinatal outcomes: Findings from a multi-ethnic pregnancy cohort	9
Prenatal particulate matter exposure and mitochondrial mutational load at the maternal-fetal interface: Effect modification by genetic ancestry	9
Type 1 diabetes mellitus: Inflammation, mitophagy, and mitochondrial function	9
Mitochondria research and neurodegenerative diseases: On the track to understanding the biological world of high complexity	9
Role of F-actin-mediated endocytosis and exercise in mitochondrial transplantation in an experimental Parkinson's disease mouse model	9
Presence and transmission of mitochondrial heteroplasmic mutations in human populations of European and African ancestry	9
The involvement of autophagy in the maintenance of endothelial homeostasis: The role of mitochondria	9
Cardiac-specific β-catenin deletion dysregulates energetic metabolism and mitochondrial function in perinatal cardiomyocytes	9