OOIR: Observatory of International Research

Papers

(The TQCC of Mitochondrion is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-03-01 to 2025-03-01.)

Article	Citations
Hsp90 and its mitochondrial homologue TRAP-1 independently regulate hypoxia adaptations in Caenorhabditis elegans	127
SIRT6 suppresses colon cancer growth by inducing apoptosis and autophagy through transcriptionally down-regulating Survivin	116
Editorial Board	98
Development of a sensitive double TaqMan Probe-based qPCR Angle-Degree method to detect mutation frequencies	73
Hemispheric analysis of mitochondrial Complex I and II activity in the mouse model of ischemia-reperfusion-induced injury	52
Mitochondrial bioenergetics and cytometric characterization of a synaptosomal preparation from mouse brain cortex	49
Mitochondrial and metabolic features of salugenesis and the healing cycle	46
The biology of mitochondrial carrier homolog 2	46
β-Hydroxybutyrate preferentially enhances neuron over astrocyte respiration while signaling cellular quiescence	45
Differential role of prolyl hydroxylases on mitochondrial function of HL-1 cells in a model of iron deficiency	40
Editorial Board	38
Mitochondrial respiration is controlled by Allostery, Subunit Composition and Phosphorylation Sites of Cytochrome c Oxidase: A trailblazer’s tale – Bernhard Kadenbach	36
Mitochondrial dysfunction and inflammasome activation in neurodegenerative diseases: Mechanisms and therapeutic implications	36
Pharmacologic enrichment of exosome yields and mitochondrial cargo	35
Augmented Parkin-dependent mitophagy underlies the hepatoprotective effect of remote ischemic conditioning used prior to hemorrhagic shock	35
The tissue-specific nature of physiological zebrafish mitochondrial bioenergetics	35
Deciphering the role of MitomiRs in cancer: A comprehensive review	33
Decoding mitochondrial quality control mechanisms: Identifying treatment targets for enhanced cellular health	33
The Interplay of Mitochondrial Dysfunction in Oral Diseases: Recent Updates in Pathogenesis and Therapeutic Implications	32
Precise annotation of Drosophila mitochondrial genomes leads to insights into AT-rich regions	31
Partial inhibition of mitochondrial-linked pyrimidine synthesis increases tumorigenic potential and lysosome accumulation	30
Diagnosis of primary mitochondrial disorders -Emphasis on myopathological aspects	28
Phenotypes and genotypes of mitochondrial diseases with mtDNA variations in Chinese children: A multi-center study	28
Mitochondrial calcium signaling in the brain and its modulation by neurotropic viruses	27
The role of mtDNA haplogroups on metabolic features in narcolepsy type 1	26

Placental mitochondrial DNA mutational load and perinatal outcomes: Findings from a multi-ethnic pregnancy cohort	26
Serum fibroblast growth factor 21 and growth differentiation factor 15: Two sensitive biomarkers in the diagnosis of mitochondrial disorders	26
Repeated mild traumatic brain injuries perturb the mitochondrial biogenesis via DNA methylation in the hippocampus of rat	26
Corrigendum to “Comparison of whole genome sequencing and targeted sequencing for mitochondrial DNA” [Mitochondrion 58 (2021) 303–310]	25
Megamitochondria plasticity: Function transition from adaption to disease	25
Cardiac-specific β-catenin deletion dysregulates energetic metabolism and mitochondrial function in perinatal cardiomyocytes	25
Genetic heterogeneity and respiratory chain enzyme analysis in pediatric Indian patients with mitochondrial disorder: Report of novel variants in POLG1 gene and their functional implication using mole	24
Identification of a novel MT-ND3 variant and restoring mitochondrial function by allotopic expression of MT-ND3 gene	24
Global view of dynamic expression and precise mapping of mitochondrial tRNAs-derived fragments during stressed conditions in S. pombe	24
Metabolic abnormality in acute stroke-like lesion and its relationship with focal cerebral blood flow in patients with MELAS: Evidence from proton MR spectroscopy and arterial spin labeling	23
Cell-free mtDNA level and its biomarker potency for ART outcome are different in follicular fluid of PCOS and non-PCOS women	23
Mitophagy pathways and Alzheimer's disease: From pathogenesis to treatment	22
Mitochondrial DNA mutations do not impact early human embryonic development	21
CMT2A-linked MFN2 mutation, T206I promotes mitochondrial hyperfusion and predisposes cells towards mitophagy	21
Long read mitochondrial genome sequencing using Cas9-guided adaptor ligation	21
Primary ovarian insufficiency in RMND1 mitochondrial disease	20
Dysregulation of mitochondrial complexes and dynamics by chronic cigarette smoke exposure Utilizing MitoQC reporter mice	20
Mitochondrial DNA haplogroups J and T increase the risk of glioma	20
Clinical heterogeneity in patients with m.4412G > A MT-TM mutation and different heteroplasmy levels	20
Leber’s hereditary optic neuropathy: Current approaches and future perspectives on Mesenchymal stem cell-mediated rescue	19
Mitochondrial functioning in Rheumatoid arthritis modulated by estrogen: Evidence-based insight into the sex-based influence on mitochondria and disease	19
The maternal genetic origin and diversity of the extant populations of the Ladakh region in India	19
Human clinical mutations in mitochondrially encoded subunits of Complex I can be successfully modeled in E. coli	18
Disturbance in communication between mitochondrial redox processes and the AMPK/PGC-1α/SIRT-1 axis influences diverse organ symptoms in lupus-affected mice	18
The molecular role of Sigmar1 in regulating mitochondrial function through mitochondrial localization in cardiomyocytes	18
Sequencing errors in Native American mitogenomes: Impact on clade definitions, haplogroup assignation, and beyond	18
Effects of chronic hydrogen peroxide exposure on mitochondrial oxidative stress genes, ROS production and lipid peroxidation in HL60 cells	17
Escherichia coli infection induces ferroptosis in bovine mammary epithelial cells by activating the Wnt/β-catenin pathway-mediated mitophagy	17
Mitochondrial acyl carrier protein, Acp1, required for iron-sulfur cluster assembly in mitochondria and cytoplasm in Saccharomyces cerevisiae	16
An integrated multi-omics approach allowed ultra-rapid diagnosis of a deep intronic pathogenic variant in PDHX and precision treatment in a neonate critically ill with lactic acidosis	16
Screening clusters of charged residues in plants’ mitochondrial proteins and biological significance	16
Cell-penetrating peptides with nanoparticles hybrid delivery vectors and their uptake pathways	16
The multifaceted modulation of mitochondrial metabolism in tumorigenesis	16
Mitogenomics of the endemic Ethiopian rats: looking for footprints of adaptive evolution in sky islands	15
Molecular machinery regulating mitochondrial calcium levels: The nuts and bolts of mitochondrial calcium dynamics	15
Alterations in inter-organelle crosstalk and Ca2+ signaling through mitochondria during proteotoxic stresses	15
Intricate role of mitochondrial calcium signalling in mitochondrial quality control for regulation of cancer cell fate	15
Micronutrients/miRs/ATP networking in mitochondria: Clinical intervention with ferroptosis, cuproptosis, and calcium burden	15
Mitochondrial miRNAs (MitomiRs): Their potential roles in breast and other cancers	14
Application research of novel peptide mitochondrial-targeted antioxidant SS-31 in mitigating mitochondrial dysfunction	14
Yeast Dnm1G178R causes altered organelle dynamics and sheds light on the human DRP1G149R disease mechanism	14
Endoplasmic reticulum & mitochondrial calcium homeostasis: The interplay with viruses	14
Molecular basis of sepsis: A New insight into the role of mitochondrial DNA as a damage-associated molecular pattern	14
Mitochondrial DNA (mtDNA) accelerates oxygen-glucose deprivation-induced injury of proximal tubule epithelia cell via inhibiting NLRC5	14
Molecular docking and simulation studies of phytocompounds derived from Centella asiatica and Andrographis paniculata against hexokinase II as mitocan agents	14
Mitochondrial transfer from mesenchymal stem cells: Mechanisms and functions	14
Altered insulin pathway compromises mitochondrial function and quality control both in in vitro and in vivo model systems	13
Mitochondria determine response to anti-programmed cell death protein-1 (anti-PD-1) immunotherapy: An evidence-based hypothesis	13
Differential responses of AMD mitochondrial DNA haplogroups to PU-91, a mitochondria-targeting drug	13
Scientific investigation of non-coding RNAs in mitochondrial epigenetic and aging disorders: Current nanoengineered approaches for their therapeutic improvement	13

Extracellular vesicles as carriers for mitochondria: Biological functions and clinical applications	13
Activation of multifunctional DNA repair APE1/Ref-1 enzyme by the dietary phytochemical Ferulic acid protects human neuroblastoma SH-SY5Y cells against Aβ(25–35)-induced oxidative stress and inflammat	13
Whole genome sequencing followed by functional analysis of genomic deletion encompassing ERCC8 and NDUFAF2 genes in a non-consanguineous Indian family reveals dysfunctional mitochondrial bioenergetics	13
Chelating mitochondrial iron and copper: Recipes, pitfalls and promise	13
WITHDRAWN: Advances in mitochondrial medicine and translational research	13
Editorial Board	13
Editorial Board	12
Novel blood and tissue-based mitochondrial D-loop mutations detected in an Iranian NAFLD patient cohort	12
Hypoxia-induced mitochondrial reactive oxygen species (mtROS) differentially regulates smooth muscle cell (SMC) proliferation of pulmonary and systemic vasculature	12
Assessment of mitochondrial DNA copy number variation relative to nuclear DNA quantity between different tissues	12
High-resolution mass spectrometric analysis of cardiolipin profiles in Barth syndrome	12
Delivery of mitoceuticals or respiratory competent mitochondria to sites of neurotrauma	12
Neuroprotective compounds alter the expression of genes coding for proteins related to mitochondrial function in activated microglia	12
Complex IV – The regulatory center of mitochondrial oxidative phosphorylation	12
Comparison of whole genome sequencing and targeted sequencing for mitochondrial DNA	11
Mitochondrial DNA alterations in the domestic dog (Canis lupus familiaris) and their association with development of diseases: A review	11
Mycobacterial origin protein Rv0674 localizes into mitochondria, interacts with D-loop and regulates OXPHOS for intracellular persistence of Mycobacterium tuberculosis	11
Mitochondrial calcium at the synapse	11
The involvement of autophagy in the maintenance of endothelial homeostasis: The role of mitochondria	11
Mitochondrial protein phosphorylation in yeast revisited	11
The roles of assembly factors in mammalian mitoribosome biogenesis	11
Traumatic brain injury metabolome and mitochondrial impact after early stage Ru360 treatment	11
GenEye24: Novel rapid screening test for the top-3 Leber’s Hereditary Optic Neuropathy pathogenic sequence variants	10
The multifaceted effects of mitochondria in kidney diseases	10
Blood mitochondrial DNA copy number: What are we counting?	10
Polysulfide inhibits hypoxia-elicited hypoxia-inducible factor activation in a mitochondria-dependent manner	10
Mitochondrial DNA copy number dynamics and associations with the prenatal environment from birth through adolescence in a population of Dominican and African American children	10
Role of mitochondrial dysfunction in the pathogenesis of rheumatoid arthritis: Looking closely at fibroblast- like synoviocytes	10
The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches	10
Mitofusin 2: The missing link between mtDNA maintenance defects and neurotransmitter disorders	10
Role of Rmd9p in 3′-end processing of mitochondrial 15S rRNA in Saccharomyces cerevisiae	10
Mitochondrial matrix-localized p53 participates in degradation of mitochondrial RNAs	10
What can we do to optimize mitochondrial transplantation therapy for myocardial ischemia–reperfusion injury?	10
Triplication of HSA21 on alterations in structure and function of mitochondria	9
Understanding the molecular basis of anti-fibrotic potential of intranasal curcumin and its association with mitochondrial homeostasis in silica-exposed mice	9
Cumulative effects of mutation accumulation on mitochondrial function and fitness	9
Stressed mitochondria: A target to intrude alzheimer’s disease	9
ACAD9 treatment with bezafibrate and nicotinamide riboside temporarily stabilizes cardiomyopathy and lactic acidosis	9
Involvement of mitochondria in Alzheimer’s disease pathogenesis and their potential as targets for phytotherapeutics	9
Tissue imaging reveals disruption of epithelial mitochondrial networks and loss of mitochondria-associated cytochrome-C in inflamed human and murine colon	9
Increased expression of SLC25A18 is associated with Alzheimer’s disease and is involved in Aβ42-induced mitochondrial dysfunction and apoptosis in neuronal cells	9
Mitochondrial ribosomal protein genes connected with Alzheimer’s and tellurite toxicity	9
The diversity and coexistence of extracellular mitochondria in circulation: A friend or foe of the immune system	9
Corrigendum to “Prognostic value of circulating mitochondrial DNA in prostate cancer and underlying mechanism” [Mitochondrion 71 (2023) 40-49]	9
Differential effects of 808-nm light on electron transport chain enzymes in isolated mitochondria: Implications for photobiomodulation initiation	9
Defective complex III mitochondrial respiratory chain due to a novel variant in CYC1 gene masquerades acute demyelinating syndrome or Leber hereditary optic neuropathy	9
The deletion of ppr2 interferes iron sensing and leads to oxidative stress response in Schizosaccharomyces pombe	9
Mitochondrial bioenergetics of breast cancer	9
Characterization of neutral sphingomyelinase activity and isoform expression in rodent skeletal muscle mitochondria	9
Mitochondrial Mechanisms in Temozolomide Resistance: Unraveling the Complex Interplay and Therapeutic Strategies in Glioblastoma	9
Prognostic value of circulating mitochondrial DNA in prostate cancer and underlying mechanism	9