OOIR: Observatory of International Research

Papers

(The TQCC of Current Alzheimer Research is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
CREB: A Multifaceted Target for Alzheimer’s Disease	53
The Association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's Disease	30
Association Between Oxidative Stress and Altered Cholesterol Metabolism in Alzheimer’s Disease Patients	30
Accelerated Epigenetic Aging in Peripheral Blood does not Predict Dementia Risk	24
Effect of High Cholesterol Regulation of LRP1 and RAGE on Aβ Transport Across the Blood-Brain Barrier in Alzheimer’s Disease	22
Neuroprotective Effect of Fucoxanthin against Intracerebroventricular Streptozotocin (ICV-STZ) Induced Cognitive Impairment in Experimental Rats	21
Diagnosis of Mild Cognitive Impairment Using Cognitive Tasks: A Functional Near-Infrared Spectroscopy Study	20
Research Progress on circRNA in Nervous System Diseases	19
Multi-Target Directed Ligands (MTDLs): Promising Coumarin Hybrids for Alzheimer’s Disease	18
An Effective Brain Imaging Biomarker for AD and aMCI: ALFF in Slow-5 Frequency Band	18
Current Challenges and Limitations in the Studies of Intrinsically Disordered Proteins in Neurodegenerative Diseases by Computer Simulations	18
Cerebrospinal Fluid and Blood CX3CL1 as a Potential Biomarker in Early Diagnosis and Prognosis of Dementia	17
Alterations in Mitochondrial Dynamic-related Genes in the Peripheral Blood of Alzheimer’s Disease Patients	16
Curcumin Prevents Neuroinflammation by Inducing Microglia to Transform into the M2-phenotype via CaMKKβ-dependent Activation of the AMP-Activated Protein Kinase Signal Pathway	15
Low Intensity Electromagnetic Fields Act via Voltage-Gated Calcium Channel (VGCC) Activation to Cause Very Early Onset Alzheimer’s Disease: 18 Distinct Types of Evidence	15
Impaired Cognitive Function is Associated with Motor Function and Activities of Daily Living in Mild to Moderate Alzheimer's Dementia	15
Investigation of Low Dose Cabazitaxel Potential as Microtubule Stabilizer in Experimental Model of Alzheimer's Disease: Restoring Neuronal Cytoskeleton	15
Weight Loss and the Risk of Dementia: A Meta-analysis of Cohort Studies	15
Cytokine Storm and Neuropathological Alterations in Patients with Neurological Manifestations of COVID-19	15
Comparative Efficacy and Acceptability of Cholinesterase Inhibitors and Memantine Based on Dosage in Patients with Vascular Cognitive Impairment: A Network Meta-analysis	15
The Relationship of Anxiety with Alzheimer’s Disease: A Narrative Review	14
Cerebral Microbleeds and White Matter Hyperintensities are Associated with Cognitive Decline in an Asian Memory Clinic Study	14
Effects of Spices (Saffron, Rosemary, Cinnamon, Turmeric and Ginger) in Alzheimer's Disease	13
Microglia and its Genetics in Alzheimer's Disease	13
Targeting Pathological Amyloid Aggregates with Conformation-Sensitive Antibodies	13

Anti-Neurodegenerative Benefits of Acetylcholinesterase Inhibitors in Alzheimer’s Disease: Nexus of Cholinergic and Nerve Growth Factor Dysfunction	13
Volumetric MRI Demonstrates Atrophy of the Olfactory Cortex in AD	13
Non-steroidal Anti-inflammatory Drugs as Candidates for the Prevention or Treatment of Alzheimer’s Disease: Do they Still Have a Role?	12
The Alzheimer’s Disease Amyloid Precursor Protein and its Neuritogenic Actions	12
Association of Dietary Prebiotic Consumption with Reduced Risk of Alzheimer’s Disease in a Multiethnic Population	11
Inflammation in Alzheimer’s Disease	11
Amyloid-beta Induced Neurotoxicity Impairs Cognition and Adult Hippocampal Neurogenesis in a Mouse Model for Alzheimer’s Disease	11
Robust Discovery of Mild Cognitive Impairment Subtypes and Their Risk of Alzheimer's Disease Conversion Using Unsupervised Machine Learning and Gaussian Mixture Modeling	11
The Contribution of Cerebral Vascular Neuropathology to Mild Stage of Alzheimer’s Dementia Using the NACC Database	11
Alzheimer’s Disease and its Related Dementia Types: A Review on Their Management Via Nanotechnology Based Therapeutic Strategies	11
Non-Ceruloplasmin Copper as a Stratification Biomarker of Alzheimer’s Disease Patients: How to Measure and Use It	10
Unfolded p53 as a Marker of Oxidative Stress in Mild Cognitive Impairment, Alzheimer’s and Parkinson’s Disease	10
Mitochondrially-Targeted Therapeutic Strategies for Alzheimer’s Disease	10
Relationship of Neurofilament Light (NfL) and Cognitive Performance in a Sample of Mexican Americans with Normal Cognition, Mild Cognitive Impairment and Dementia	10
Metabolic Syndrome, Alzheimer’s Disease, and Covid 19: A Possible Correlation	10
Electromagnetic Field in Alzheimer’s Disease: A Literature Review of Recent Preclinical and Clinical Studies	9
Functional Connectivity Alterations Based on the Weighted Phase Lag Index: An Exploratory Electroencephalography Study on Alzheimer’s Disease	9
Neuroprotector Effect of Daily 8-Minutes of High-Intensity Interval Training in Rat Aβ1-42 Alzheimer Disease Model	9
Carotid Arterial Stiffness and Cerebral Blood Flow in Amnestic Mild Cognitive Impairment	9
IL-8 and MCP-1 Impact on Tau Phosphorylation and Phosphatase Activity	9
Serine Racemase Expression Differentiates Aging from Alzheimer’s Brain	9
Degradation Products of Amyloid Protein: Are They The Culprits?	8
A Comparison of Neurocognitive Decline in Older Adults in Same-Sex and Opposite-Sex Relationships	8
Uncovering the Impact of Aggrephagy in the Development of Alzheimer's Disease: Insights Into Diagnostic and Therapeutic Approaches from Machine Learning Analysis	8
β-Amyloid is an Immunopeptide and Alzheimer’s is an Autoimmune Disease	8
Huntingtin Levels are Elevated in Hippocampal Post-Mortem Samples of Alzheimer’s Disease Brain	8
RAGE Isoforms, its Ligands and their Role in Pathophysiology of Alzheimer’s Disease	8
Neutrophil Granule Proteins Inhibit Amyloid Beta Aggregation and Neurotoxicity	8
Retinal Changes in Transgenic Mouse Models of Alzheimer’s Disease	8
Mitochondrial Dysfunction as a Causative Factor in Alzheimer’s Disease-Spectrum Disorders: Lymphocytes as a Window to the Brain	8
Astrocyte Reactivity in Alzheimer’s Disease: Therapeutic Opportunities to Promote Repair	8
Microglial Store-operated Calcium Signaling in Health and in Alzheimer’s Disease	8
Codonopsis pilosula Polysaccharides Alleviate Aβ1-40-Induced PC12 Cells Energy Dysmetabolism via CD38/NAD+ Signaling Pathway	8
Hippocampal and Amygdalar Morphological Abnormalities in Alzheimer’s Disease Based on Three Chinese MRI Datasets	7
Polymorphism Rs2421943 of the Insulin-Degrading Enzyme Gene and the Risk of Late-Onset Alzheimer’s Disease	7
Heterogeneity of Tau Deposition and Microvascular Involvement in MCI and AD	7
The Interaction of Dynamic Cerebral Autoregulation and Neurovascular Coupling in Cognitive Impairment	7
Association of Red Blood Cell Indices with Mild Cognitive Impairment in Chinese Elderly Individuals: A Matched Case-control Study	7
Mild Behavioral Impairment: An Early Sign and Predictor of Alzheimer's Disease Dementia	7
High Fat Diet Aggravates AD-Related Pathogenic Processes in APP/PS1 Mice	7
Identification of Somatic Mutations in Dementia-related Genes in Cancer Patients	7
Gastrointestinal Changes and Alzheimer's Disease	7
Clinical Phenotype and Mutation Spectrum of Alzheimer’s Disease with Causative Genetic Mutation in a Chinese Cohort	7
Exendin-4 Improves Cognitive Function of Diabetic Mice via Increasing Brain Insulin Synthesis	7
Dihydroartemisinin Ameliorates Decreased Neuroplasticity-Associated Proteins and Excessive Neuronal Apoptosis in APP/PS1 Mice	7
A Novel Probiotic Formula, BIOCG, Protects Against Alzheimer’s-Related Cognitive Deficits via Regulation of Dendritic Spine Dynamics	6
Tele-Mindfulness for Dementia's Family Caregivers: A Randomized Trial with a Usual Care Control Group	6
Oxidative Damage of Proteins Precedes Loss of Cholinergic Phenotype in the Septal Neurons of Olfactory Bulbectomized Mice	6
A Comprehensive Investigation of Molecular Signatures and Pathways Linking Alzheimer’s Disease and Epilepsy via Bioinformatic Approaches	6
Digital Intervention for the Management of Alzheimer’s Disease	6

Automatic Assessment of Cognitive Tests for Differentiating Mild Cognitive Impairment: A Proof of Concept Study of the Digit Span Task	6
Sixteen Weeks of Aerobic Exercise does not Alter Resting-state Connectivity of the Precuneus in Patients with Alzheimer’s Disease	6
Enhanced Anti-Amyloid Effect of Combined Leptin and Pioglitazone in APP/PS1 Transgenic Mice	6
Risk Factors for Alzheimer’s Disease: An Epidemiological Study	6
Inflammation in the CNS: Understanding Various Aspects of the Pathogenesis of Alzheimer's Disease	6
Parkinson’s Symptoms and Caregiver Affiliate Stigma: A Multinational Study	6
Diversity and Regulation of Astrocyte Neurotoxicity in Alzheimer's Disease	6
Impairment of Store-operated Calcium Entry: Implications in Alzheimer’s Neurodegeneration	6
Association Serum S100B Protein in Alzheimer’s Disease: A Case Control Study from South India	6
Development and Validation of a Model to Identify Alzheimer’s Disease and Related Syndromes in Administrative Data	6
Theracurmin Supplementation May be a Therapeutic Option for Older Patients with Alzheimer’s Disease: A 6-Month Retrospective Follow-Up Study	6
Clinical, Neuropsychological, and Neuroimaging Characteristics of Amyloid- positive vs. Amyloid-negative Patients with Clinically Diagnosed Alzheimer’s Disease and Amnestic Mild Cognitive Impairment	6
Rectifying Attenuated Store-Operated Calcium Entry as a Therapeutic Approach for Alzheimer’s Disease	6
Salivary Aβ Secretion and Altered Oral Microbiome in Mouse Models of AD	6
Caffeine Improve Memory and Cognition via Modulating Neural Progenitor Cell Survival and Decreasing Oxidative Stress in Alzheimer's Rat Model	6
Palmitoylated Prolactin-releasing Peptide Reduced Aβ Plaques and Microgliosis in the Cerebellum: APP/PS1 Mice Study	6
Risk Assessment During Longitudinal Progression of Cognition in Older Adults: A Community-based Bayesian Networks Model	6
Functional Roles of Neuronal Nitric Oxide Synthase in Neurodegenerative Diseases and Mood Disorders	5
APP/PS1 Gene-Environment Noise Interaction Aggravates AD-like Neuropathology in Hippocampus Via Activation of the VDAC1 Positive Feedback Loop	5
BACE-1 Inhibitors Targeting Alzheimer's Disease	5
The Gut Microbiome and Alzheimer’s Disease: A Growing Relationship	5
Physical Work and Exercise Reduce the Risk of Cognitive Impairment in Older Adults: A Population-based Longitudinal Study	5
From Infection to Inoculation: Expanding the Microbial Hypothesis of Alzheimer’s Disease	5
Blood Neurofilament Light Chain in Different Types of Dementia	5
Inflammatory Biomarkers in AD: Implications for Diagnosis	5
Poststroke Cognitive Impairment: A Longitudinal Follow-Up and Pre/Poststroke Mini-Mental State Examination Comparison	5
The Effect of Gut Microbe Dysbiosis on the Pathogenesis of Alzheimer's Disease (AD) and Related Conditions	5
Directed Network Defects in Alzheimer's Disease Using Granger Causality and Graph Theory	5
Connectivity and Patterns of Regional Cerebral Blood Flow, Cerebral Glucose Uptake, and Aβ-Amyloid Deposition in Alzheimer's Disease (Early and Late-Onset) Compared to Normal Ageing	5
Random-Forest-Algorithm-Based Applications of the Basic Characteristics and Serum and Imaging Biomarkers to Diagnose Mild Cognitive Impairment	5
Effects of Supplementation with Probiotics in Experimental Models of Alzheimer's Disease: A Systematic Review of Animal Experiments	5
Elucidating the Risk Factors for Progression from Amyloid-Negative Amnestic Mild Cognitive Impairment to Dementia	5
Synthesis, Molecular Docking, and Biological Evaluation of Benzimidazole Derivatives as Selective Butyrylcholinesterase Inhibitors	5
Blood Biomarkers Discriminate Cerebral Amyloid Status and Cognitive Diagnosis when Collected with ACD-A Anticoagulant	5
Modifiable Risk Factors for Dementia: The Role of Gut Microbiota	5
Pesticide Exposure and Alzheimer’s Disease: A Case-control Study	5
Vascular Lesions and Brain Atrophy in Alzheimer’s, Vascular and Mixed Dementia: An Optimized 3T MRI Protocol Reveals Distinctive Radiological Profiles	5
Interaction of Exogenous Butyrylcholinesterase with β-Amyloid Plaques in 5XFAD/Butyrylcholinesterase-Knockout Mouse Brain	5
Acting Before; A Combined Strategy to Counteract the Onset and Progression of Dementia	5
A Comparison of Two Statistical Mapping Tools for Automated Brain FDG-PET Analysis in Predicting Conversion to Alzheimer’s Disease in Subjects with Mild Cognitive Impairment	5
A Timeline of Ca2+/cAMP Signalling: From Basic Research to Potential Therapeutics for Dementia	5