OOIR: Observatory of International Research

Papers

(The TQCC of Current Molecular Medicine is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Free Radicals and Oxidative Stress: Signaling Mechanisms, Redox Basis for Human Diseases, and Cell Cycle Regulation	61
Rapid Determination of Full and Empty Adeno-Associated Virus Capsid Ratio by Capillary Isoelectric Focusing	27
The Role of the PI3K/AKT/mTOR Signalling Pathway in Male Reproduction	26
An Overview of Available Antimalarials: Discovery, Mode of Action and Drug Resistance	24
The Roles of Mitochondrial Dysfunction and Reactive Oxygen Species in Aging and Senescence	22
Circulating miRNA in Atherosclerosis: A Clinical Biomarker and Early Diagnostic Tool	22
Quercetin: A Potential Candidate for the Treatment of Arthritis	21
The Role of Retinoblastoma Protein in Cell Cycle Regulation: An Updated Review	19
Studying Adsorption and Cellular Toxicity of Boron Nitride Nanostructure versus Melphalan Anti-ovarian Cancer Drug	19
The Antihypertensive, Antimicrobial and Anticancer Peptides from Arthrospira with Therapeutic Potential: A Mini Review	19
JAK2-mediated Intracellular Signaling	18
Lavender Plant: Farming and Health Benefits	15
Human Recombinant Relaxin (Serelaxin) as Anti-fibrotic Agent: Pharmacology, Limitations and Actual Perspectives	14
The Functional Role of Long Non-coding RNA UCA1 in Human Multiple Cancers: a Review Study	14
Recent Advances in the Analysis Full/Empty Capsid Ratio and Genome Integrity of Adeno-associated Virus (AAV) Gene Delivery Vectors	14
Transcriptomic Signatures in Colorectal Cancer Progression	13
CTLA-4: As an Immunosuppressive Immune Checkpoint in Breast Cancer	13
Molecular Regulatory Roles of Long Non-coding RNA HOTTIP: An Overview in Gastrointestinal Cancers	12
Metaxalone Suppresses Production of Inflammatory Cytokines Associated with Painful Conditions in Mouse Macrophages RAW264.7 Cells in Vitro: Synergistic Effect with β-caryophyllene	12
Helicobacter pylori Biofilm and New Strategies to Combat it	12
NPC1 as a Modulator of Disease Severity and Viral Entry of SARSCoV- 2	12
Regenerative Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles	12
Metabolic Ink Lactate Modulates Epigenomic Landscape: A Concerted Role of Pro-tumor Microenvironment and Macroenvironment During Carcinogenesis	12
Role of Oxidative Stress and Antioxidant Supplementation in Male Fertility	12
The Role of Pro-fibrotic Myofibroblasts in Systemic Sclerosis: From Origin to Therapeutic Targeting	12

Triazavirin - Potential Inhibitor for 2019-nCoV Coronavirus M Protease: A DFT Study	11
Quercetin and its Relative Therapeutic Potential Against COVID-19: A Retrospective Review and Prospective Overview	11
Circular RNAs: Emerging Modulators in the Pathophysiology of Polycystic Ovary Syndrome and their Clinical Implications	11
The Therapeutic Effect of Stem Cells on Chemotherapy-Induced Premature Ovarian Failure	10
OSI-027 Alleviates Oxaliplatin Chemoresistance in Gastric Cancer Cells by Suppressing P-gp Induction	10
Resveratrol Induces Apoptosis and Attenuates Proliferation of MCF-7 Cells in Combination with Radiation and Hyperthermia	10
Transcription Factors – the Essence of Heart Regeneration: A Potential Novel Therapeutic Strategy	10
Sperm Mitochondria, the Driving Force Behind Human Spermatozoa Activities: Its Functions and Dysfunctions - A Narrative Review	9
Vitamin D and Non-coding RNAs: New Insights into the Regulation of Breast Cancer	9
CD155: A Key Receptor Playing Diversified Roles	9
Cartilage Tissue and Therapeutic Strategies for Cartilage Repair	9
The Role of Skin and Gut Microbiome and Epigenetic Modifications in Skin-Autoimmune Disorders	9
Obesity and Insulin Resistance: A Review of Molecular Interactions	9
Wound Healing Properties of Exosomes — A Review and Modelling of Combinatorial Analysis Strategies	9
Ketogenic Diet: A Promising Neuroprotective Composition for Managing Alzheimer’s Diseases and its Pathological Mechanisms	9
Diabetic Neuropathy: Review on Molecular Mechanisms	9
Targeting Tumor-derived Exosomes Expressing CD73: New Opportunities in the Pathogenesis and Treatment of Cancer	9
Hyaluronic Acid and Regenerative Medicine: New Insights into the Stroke Therapy	9
Current Progress on Neuroinflammation-mediated Postoperative Cognitive Dysfunction: An Update	9
The Antitumor Effects of Icaritin Against Breast Cancer is Related to Estrogen Receptors	9
Targeting Abnormal Nrf2/HO-1 Signaling in Amyotrophic Lateral Sclerosis: Current Insights on Drug Targets and Influences on Neurological Disorders	8
Intraocular Exosomes in Eye Diseases	8
An In vivo Immunohistochemical Study on MacroH2A.1 in Lung and Lymph-Node Tissues Exposed to an Asbestiform Fiber	8
The Prognostic Value of Cytokeratin and Extracellular Collagen Expression in Urinary Bladder Cancer	8
SARS-CoV-2 Proteins: Are They Useful as Targets for COVID-19 Drugs and Vaccines?	8
Cancer Immunology and CAR-T Cells: A Turning Point Therapeutic Approach in Colorectal Carcinoma with Clinical Insight	8
Transcription Factors in Deriving β Cell Regeneration: A Potential Novel Therapeutic Target	8
Vaccine Plasmid Topology Monitoring by Capillary Gel Electrophoresis	8
ALK7 Inhibition Protects Osteoblast Cells Against High Glucoseinduced ROS Production via Nrf2/HO-1 Signaling Pathway	8
Cholesterol: A Prelate in Cell Nucleus and its Serendipity	8
Cosmetic Fat Transplantation: A Review	7
Metabolomics Work Flow and Analytics in Systems Biology	7
Combinatorial Chemosensitive Nanomedicine Approach for the Treatment of Breast Cancer	7
Ferroptosis and Cancer Immunotherapy	7
LncRNAs Roles in Chemoresistance of Cancer Cells	7
MicroRNAs Implications in the Onset, Diagnosis, and Prognosis of Osteosarcoma	7
Genome Editing with CRISPR-Cas9: A Budding Biological Contrivance for Colorectal Carcinoma Research and its Perspective in Molecular Medicine	7
The Emerging Role of LncRNA FENDRR in Multiple Cancers: A Review	7
Altered Expression of TRIM Proteins - Inimical Outcome and Inimitable Oncogenic Function in Breast Cancer with Diverse Carcinogenic Hallmarks	7
Chromosome 9 Inversion: Pathogenic or Benign? A Comprehensive Systematic Review of all Clinical Reports	7
Role of DACH1 on Proliferation, Invasion, and Apoptosis in Human Lung Adenocarcinoma Cells	7
SHMT2 is Associated with Tumor Purity, CD8+ T Immune Cells Infiltration, and a Novel Therapeutic Target in Four Different Human Cancers	7
Targeting tumor hypoxia and hypoxia-inducible factors (HIFs) for the treatment of cancer- A story of transcription factors with novel approach in molecular medicine	7
Exosomes Harnessed as Nanocarriers for Cancer Therapy - Current Status and Potential for Future Clinical Applications	6
Therapeutic Measures for the Novel Coronavirus: A Review of Current Status and Future Perspective	6
Critical Role of NFκB in the Pathogenesis of Non-alcoholic Fatty Liver Disease: A Widespread Key Regulator	6
Asiaticoside Prevents Oxidative Stress and Apoptosis in Endothelial Cells by Activating ROS-dependent p53/Bcl-2/Caspase-3 Signaling Pathway	6
Heat Shock Proteins Regulating Toll-like Receptors and the Immune System could be a Novel Therapeutic Target for Melanoma	6
N-glycan Analysis in Molecular Medicine: Innovator and Biosimilar Protein Therapeutics	6
Bone Marrow Stromal Stem Cell Fate Decision: A Potential Mechanism For Bone Marrow Adipose Increase with Aging-related Osteoporosis	6

Current Progress and Perspectives of CDC20 in Female Reproductive Cancers	6
The Roles of microRNAs in Multidrug-Resistance Mechanisms in Gastric Cancer	6
The Regulatory Role of Pivotal MicroRNAs in the AKT Signaling Pathway in Breast Cancer	6
Artemisia Species as a New Candidate for Diabetes Therapy: A Comprehensive Review	6
Silencing of Long Non-coding RNA H19 Alleviates Lipopolysaccharide (LPS)-induced Apoptosis and Inflammation Injury by Regulating miR-140-5p/TLR4 Axis in Cell Models of Pneumonia	6
Cell-adhesion Molecules as Key Mechanisms of Tumor Invasion: The Case of Breast Cancer	6
Current Status of Alzheimer’s Disease and Pathological Mechanisms Investigating the Therapeutic Molecular Targets	6
COVID-19 and ARDS: Update on Preventive and Therapeutic Venues	6
Potential Involvement of Extracellular Citrate in Brain Tumor Progression	6
Autophagy as an Anti-senescent in Aging Neurocytes	6
Role of Innate Immune and Inflammatory Responses in the Development of Secondary Diabetic Complications	6
Preclinical Evidence-based Review on Therapeutic Potential of Eugenol for the Treatment of Brain Disorders	6
Proteomics Profiling of Plasma Exosomes in VKH Patients	6
Research Update on the Pathophysiological Mechanisms of Heart Failure with Preserved Ejection Fraction	6
An Overview of the Latest Applications of Platelet-Derived Microparticles and Nanoparticles in Medical Technology 2010-2020	6
Combating the Progression of Novel Coronavirus SARS-CoV-2 Infectious Disease: Current State and Future Prospects in Molecular Diagnostics and Drug Discovery	6
MicroRNAs in Helminth Parasites: A Systematic Review	5
High Plasmatic Levels of Advanced Glycation End Products are Associated with Metabolic Alterations and Insulin Resistance in Preeclamptic Women	5
Correlation Between Dexamethasone and miRNAs in the Regulation of Apoptosis, Drug-resistance, and Metastasis of Cancer Cell	5
A Review of DNA and Histone Methylation Alterations in the New Era of Diagnosis and Treatment of Retinal Diseases	5
Piwi-interacting RNAs (piRNAs) and Colorectal Carcinoma: Emerging Non-invasive diagnostic Biomarkers with Potential Therapeutic Target Based Clinical Implications	5
N-glycomic Analysis of Z(IgA1) Partitioned Serum and Salivary Immunoglobulin A by Capillary Electrophoresis	5
Parathyroid Hormone-regulation of Runx2 by MiR-290 for Matrix Metalloproteinase-13 Expression in Rat Osteoblastic Cells	5
The Ineluctable Role of ACE-2 Receptors in SARS COV-2 Infection and Drug Repurposing as a Plausible SARS COV-2 Therapy: A Concise Treatise	5
Effects of MCU-mediated Ca2+ Homeostasis on Ovarian Cancer Cell SKOV3 Proliferation, Migration and Transformation	5
Association of High-Mobility Group Box-1 with Inflammationrelated Cytokines in the Aqueous Humor with Acute Primary Angle-Closure Eyes	5
Role of Extracellular Vesicles in Alzheimer’s Disease: Current Advances	5
Aminooxy-Acetic Acid Inhibits Experimental Autoimmune Uveitis by Modulating the Balance between Effector and Regulatory Lymphocyte Subsets	5
Epigenetic Reprogramming and Landscape of Transcriptomic Interactions: Impending Therapeutic Interference of Triple-Negative Breast Cancer in Molecular Medicine	5
The Effect of Bacterial Composition Shifts in the Oral Microbiota on Alzheimer's Disease	5
Innate Immunity Alterations in Type 2 Diabetes Mellitus: Understanding Infection Susceptibility	5
Low pH and Temperature of Airway Surface Liquid are Key Determinants that Potentiate SARS-CoV-2 Infectivity	5
MicroRNA-34c-5p Reduces Malignant Properties of Lung Cancer Cells through Regulation of TBL1XR1/Wnt/β-catenin Signaling	5
Darolutamide as a Second-Generation Androgen Receptor Inhibitor in the Treatment of Prostate Cancer	5
The Key Roles of Makorin RING Finger Protein 3 (MKRN3) During the Development of Pubertal Initiation and Central Precocious Puberty (CPP)	5
Crocetin Suppresses Uterine Ischemia/Reperfusion-induced Inflammation and Apoptosis through the Nrf-2/HO-1 Pathway	5
The Key Role of Akt Protein Kinase in Metabolic-Inflammatory Pathways Cross-Talk: TNF-α Down-Regulation and Improving of Insulin Resistance in HepG2 Cell Line	5
Gastric Cancer Diagnosis: From Imaging Techniques to Biochemical Biomarkers	5
Melanocyte Adhesion and Apoptosis in Vitiligo: Linking Puzzle Blocks	4
Harnessing Drug Repurposing for Exploration of New Diseases: An Insight to Strategies and Case Studies	4
Caffeic Acid Phenethyl Ester Inhibits Ubiquitination and Degradation of p53 and Blocks Cervical Cancer Cell Growth	4
Assimilating Epigenetics and Transcriptomics for the Identification of Prognostic Novel Biomarkers and Imminent Targets in Colorectal Carcinoma with Therapeutic Potential	4
Ferroptosis Inhibitor Regulates the Disease Progression of Systematic Lupus Erythematosus Mice Model Through Th1/Th2 Ratio	4
Atractylodes-I Overcomes the Oxidative Stress-induced Colonic Mucosal Epithelial Cells Dysfunction to Prevent Irritable Bowel Syndrome Via Modulating the miR-34a-5p-LDHA Signaling Pathway	4
High Concentration of Dezocine Induces Immune Escape of Lung Cancer and Promotes Glucose Metabolism through Up-Regulating PD-L1 and Activating the NF-κB Pathway	4
Pharmacodynamic Stance of Phytoconstituents as a Gastric Ulcer Protective Mechanism: An Overview	4
Cytokine Analysis in Patients with Different Stages of Thromboangiitis Obliterans	4
Oxidative versus Reductive Stress in Breast Cancer Development and Cellular Mechanism of Alleviation: A Current Perspective with Anti-breast Cancer Drug Resistance	4
An Insight into the Molecular Mechanism of Mitochondrial Toxicant-induced Neuronal Apoptosis in Parkinson’s Disease	4
Molecular Mechanisms of miR-214 Involved in Cancer and Drug Resistance	4
Extracellular Vesicles in Tumor Diagnosis: A Mini-Review	4
A Systematic Review of Potential Immunotherapies Targeting PRAME in Retinoid Resistant Oral Potentially Malignant Disorders and Oral Cancer	4
Molecular Characterization of SARS-CoV-2	4
A Comprehensive Review on Cross-talk of Human Papilloma Virus Oncoproteins and Developmental/Self-Renewal Pathways During the Pathogenesis of Uterine Cervical Cancer	4
MicroRNA-Based Biomarkers in Lung Cancer: Recent Advances and Potential Applications	4
The Role of Vitamins in DNA Methylation as Dietary Supplements or Neutraceuticals: A Systematic Review	4
Investigation of the Anti-Cancer Effects of Free and PLGA-PAA Encapsulated Hydroxytyrosol on the MCF-7 Breast Cancer Cell Line	4
Bacteriocins: New Potential Therapeutic Candidates in Cancer Therapy	4
A Research Update on Exendin-4 as a Novel Molecule Against Parkinson’s Disease	4
Cellular Functions of Small Heat Shock Proteins (HSPB) in Hepatocellular Carcinoma	4
Effects of Carvedilol on the Expression of TLR4 and its Downstream Signaling Pathway in the Liver Tissues of Rats with Cholestatic Liver Fibrosis	4
Psoralidin Induced Differentiation from Adipose-derived Stem Cells to Nucleus Pulposus-like Cells by TGF-β/Smad Signaling	4
MicroRNAs and their Implications in CD4+ T-cells, Oligodendrocytes and Dendritic Cells in Multiple Sclerosis Pathogenesis	4
miR-638: A Promising Cancer Biomarker with Therapeutic Potential	4
Circular RNAs and Glioma: Small Molecule with Big Actions	4
Peptide and Small Molecule Inhibitors Targeting Myeloid Cell Leukemia 1 (Mcl-1) as Novel Antitumor Agents	4
Emerging Treatment Approaches for COVID-19 Infection: A Critical Review	4
Aberrant β-catenin Activity in Hepatoid Adenocarcinoma of the Stomach	4
Legacy Effect of Antioxidant N-acetylcysteine in Cellular Senescence of Diet-induced Obesity Mice	4