OOIR: Observatory of International Research

Papers

(The TQCC of Current Molecular Medicine is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
NF-κB1 Intronic Region Polymorphisms as Risk Factor for Head and Neck Cancer in HPV-Infected Population from Pakistan	133
USP3 inhibition is Active Against Chemo-resistant Hepatocellular Carcinoma Anchorage-independent Growth via Suppressing Wnt/β-catenin	40
Pre-clinical Efficacy and Safety Pharmacology of PEGylated Recombinant Human Endostatin	32
Intracellular Ellagic Acid Derived from Goat Urine DMSO Fraction (GUDF) Predicted as an Inhibitor of c-Raf Kinase	31
Attenuation of NLRP3 Inflammasome by Cigarette Smoke is Correlated with Decreased Defense Response of Oral Epithelial Cells to Candida albicans	29
In Transfusion-Dependent Thalassemia Children, Increased Iron Overload is Associated with Lower Serum Alpha-Klotho, Which is Strongly Associated with Lower Total and Ionized Calcium Concentrations	27
Altered Expression of TRIM Proteins - Inimical Outcome and Inimitable Oncogenic Function in Breast Cancer with Diverse Carcinogenic Hallmarks	26
Transcription Factors in Deriving β Cell Regeneration: A Potential Novel Therapeutic Target	24
Aberrant β-catenin Activity in Hepatoid Adenocarcinoma of the Stomach	22
Free Radicals and Oxidative Stress: Signaling Mechanisms, Redox Basis for Human Diseases, and Cell Cycle Regulation	21
Epigenetic Mechanisms of Antibiotic Resistance	18
Sodium Butyrate Pre-Treatment Enhance Differentiation of Bone Marrow Mesenchymal Stem Cells (BM-MSCs) into Hepatocytes and Improve Liver Injury	17
Human Recombinant Relaxin (Serelaxin) as Anti-fibrotic Agent: Pharmacology, Limitations and Actual Perspectives	17
Ferroptosis and Cancer Immunotherapy	17
COL12A1 Promotes Osteosarcoma Progression via the FAK/PI3K/AKT/mTOR Pathway	16
CRISPR-Cas9: A Potent Gene-editing Tool for the Treatment of Cancer	15
NLRP3 Inflammasome Triggers Inflammation of Obstructive Sleep Apnea	15
MicroRNA-Based Biomarkers in Lung Cancer: Recent Advances and Potential Applications	14
A Mini-Review on Elisa-Based Diagnosis of Schistosomiasis	14
Diet-induced Obesity Differentially Modulates Cardiac Inflammatory Status in the C57 and FVB Mouse Strains	14
Targeting ADAM10 in Renal Diseases	13
The Role of the TRIM Family in Lung Cancer Development: An Emerging Player with Therapeutic Potential	13
The Importance of mir-491-5p in Various Cancers	13
Anti-Glioblastoma Effects of Dorzolamide Alone and in Combination with Temozolomide on U87 Cells and CD133+Glioblastoma Stem Cells	13
An Insight into Novel Sperm Cell Proteins as Bio-markers for Male Infertility: A Review	13

CD4⁺ T-cell Subsets and Cytokine Signature in Pemphigus Foliaceus Clinical Stratification beyond the th1/Th2 Paradigm	13
Anlotinib Inhibiting Mantle Cell Lymphoma Proliferation and Inducing Apoptosis through PI3K/AKT/mTOR Pathway	13
Ribosomal DNA and Neurological Disorders	12
Follicular Helper T Cells in Peyer's Patches and Galactose- Deficient Iga1 Contribute to Iga Nephropathy	12
Study on the Mechanism of Notch Pathway Mediates the Role of Lenvatinib-resistant Hepatocellular Carcinoma Based on Organoids	12
An Updated Review of the Pre-Clinical Role of microRNAs and their Contribution to Colorectal Cancer	12
High Glycolysis and Lipid Metabolism Status Predicts Poor Prognosis in Colorectal Cancer Patients	12
Reduction of ACE2 Serum Concentrations by Telbivudine in Chronic Hepatitis B Patients	12
Potential Roles of 5-HT₃ Receptor Antagonists in Reducing Chemotherapy-induced Peripheral Neuropathy (CIPN)	11
Loss of ARHGAP40 in Breast Cancer by Hypermethylation and its Clinical Significance	11
ERK/MAPK Signalling Pathway Regulates MMP2 through ETS1 in Renal Clear Cell Carcinoma	11
The Mechanosensitive Ion Channel Piezo1 Promotes Obliterative Bronchiolitis through YAP-Dependent Epithelial-to-Mesenchymal Transition	11
Structural and Pharmacological Network Focused on MiRNAs Involved in Rheumatoid Arthritis: A Systematic Review	11
SMAC/DIABLO: A Guardian Angel in Boosting Anticancer Drug-Induced Apoptosis	11
Novel Insights of ANGPTL-3 on Modulating Cholesterol Efflux Capacity Induced by HDL Particle	10
Physicochemical Stimulus-Responsive Systems Targeted with Antibody Derivatives	10
DFT Study of Interaction between Teriflunomide and β-cyclodextrin	10
A Mechanism Study on the Antioxidant Pathway of Keap1-Nrf2- ARE Inhibiting Ferroptosis in Dopaminergic Neurons	10
Update on Mesenchymal Stem Cells: A Crucial Player in Cancer Immunotherapy	10
LKB1 Mutations Enhance Radiosensitivity in Non-Small Cell Lung Cancer Cells by Inducing G2/M Cell Cycle Phase Arrest	10
Recombinant Unique Cartilage Matrix-associated Protein Potentiates Osteogenic Differentiation and Mineralization of MC3T3-E1 Cells	10
Enhancement of Platinum-Based Drug Sensitivity in Ovarian Cancer Cells Through Hyperthermia-Induced Activation of the TGF-β1/β-Catenin Signaling Pathway	9
Combating the Progression of Novel Coronavirus SARS-CoV-2 Infectious Disease: Current State and Future Prospects in Molecular Diagnostics and Drug Discovery	9
Dexmedetomidine Attenuates Spinal Cord Ischemia-reperfusion Injury in Rabbits by Decreasing Oxidation and Apoptosis	9
Glaucoma: Biological Mechanism and its Clinical Translation	9
CD155: A Key Receptor Playing Diversified Roles	9
CsHscB Derived from a Liver Fluke Clonorchis sinensis Ameliorates Cholestatic Hepatic Fibrosis in a Mouse Model of Sclerosing Cholangitis	9
HMGB1/RAGE Signaling Regulates Th17/IL-17 and Its Role in Bronchial Epithelial-Mesenchymal Transformation	9
Detailed Review of Melatonin and its Role in Managing the Symptoms of Depression	9
Clock-Sleep Communication	9
Triazavirin - Potential Inhibitor for 2019-nCoV Coronavirus M Protease: A DFT Study	9
The Role of Hypoxia-inducible Factor-1 in Bladder Cancer	9
Natural Compounds as Integrative Therapy for Liver Protection against Inflammatory and Carcinogenic Mechanisms: From Induction to Molecular Biology Advancement	8
Time- and Concentration-Dependent Stimulation of Oxidative Stress in Chondrocytes by Intracellular Soluble Urate	8
Association between Sputum Culture Conversion and Body Mass Index among Multidrug-Resistant Tuberculosis Patients in Punjab, Pakistan: A Multicenter Retrospective Study	8
Immunohistochemical Analysis of CYP11B2 (Aldosterone Synthase) and Evaluation of the HISTALDO Classification in Patients with Primary Aldosteronism	8
Exploring the Gut Microbiota as a Promising Target for Breast Cancer Treatment	8
2-DG Promotes the Proliferation, Differentiation, Migration, and Resistance to Oxidative Stress of Mesenchymal Stem Cells through Hippo Signaling	8
Stem Cells as a Novel Source for Regenerative Medicinal Applications in Alzheimer's Disease: An Update	8
Neuroprotective Potential of Hesperidin as Therapeutic Agent in the Treatment of Brain Disorders: Preclinical Evidence-based Review	8
Inducing Tumor Cell Apoptosis: Mediated Survivin miRNA by Ultrasound and Cationic Lipid Contrast Agent	8
Pharmacological Activation of AMPK Prevents Drp1-mediated Mitochondrial Fission and Alleviates Hepatic Steatosis In vitro	8
LINC00665: A Promising Biomarker in Gastrointestinal Tumors	8
Astragaloside IV Protects Against IL-1β-Induced Chondrocyte Damage via Activating Autophagy	8
Hypoxia Affects Mitochondrial Stress and Facilitates Tumor Metastasis of Colorectal Cancer Through Slug SUMOylation	8
Role of MicroRNA in Hypoxic Tumours and their Potential as Biomarkers for Early Detection of Cancer	8
Interferon Signature’s Members, a Novel Altered Correlation upon Interferon-β Treatment in Multiple Sclerosis Patients	8
Elucidating the Causal Dynamics between Inflammatory Proteins and Atrial Fibrillation Risk Through Bidirectional Mendelian Randomization	8
The Diagnostic and Prognostic Value of Plasma Circulating CircNUP98 for Nasopharyngeal Carcinoma	8
The Emerging Role of Long Non-coding RNA 01296 in Human Malignancies	8

Targeting Abnormal Nrf2/HO-1 Signaling in Amyotrophic Lateral Sclerosis: Current Insights on Drug Targets and Influences on Neurological Disorders	8
Neuroprotective Role of MiRNA-9 in Neurological Diseases: A Mini Review	7
Leukaemia Infection Diagnosis and Intestinal Flora Disorder	7
Asiaticoside Prevents Oxidative Stress and Apoptosis in Endothelial Cells by Activating ROS-dependent p53/Bcl-2/Caspase-3 Signaling Pathway	7
Molecular Targeting and Novel Therapeutic Approaches against Fungal Infections	7
Apolipoprotein A1 Inhibits Adipogenesis Progression of Human Adipose-Derived Mesenchymal Stem Cells	7
Proteomics Profiling of Plasma Exosomes in VKH Patients	7
Analysis of Cytokine mRNA Expression During Zika Virus Infection In Mesocricetus auratus	7
Multiplex PCR System for the Diagnosis of Plague	7
ORLNC1 Suppresses Cell Growth in HER2-Positive Breast Cancer via miRNA-296 Sponging	7
Bioprinting: From Technique to Application in Tissue Engineering and Regenerative Medicine	7
Genetic Association Between Sleep Traits and Vertigo Risk: A Two-Sample Bidirectional Mendelian Randomization Study	7
Hydroxysafflor Yellow A-Induced Osteoblast Differentiation and Proliferation of BM-MSCs by Up-Regulating Nuclear Vitamin D Receptor	7
Mesenchymal Stem Cell-derived Exosomes Affect Macrophage Phenotype: A Cell-free Strategy for the Treatment of Skeletal Muscle Disorders	7
The Association between Cadmium Exposure and Thyroid Function in Animals: A Systematic Review	6
Investigation of the Anti-Cancer Effects of Free and PLGA-PAA Encapsulated Hydroxytyrosol on the MCF-7 Breast Cancer Cell Line	6
Bioactive Loaded Lipid-based Nanostructures: A Novel Insight for Age-related Neurodegeneration	6
WITHDRAWN: LncRNA-PVT1 Inhibition Protects Neuron Injury During Cerebral Ischemia Injury through Targeting the miRNA-187-3p- MyD88 Signaling Pathway	6
Targeting Ubiquitin-specific Protease 5 Overcomes Chemoresistance via Negatively Regulating p53 in Gastric Cancer	6
Current Progress on Neuroinflammation-mediated Postoperative Cognitive Dysfunction: An Update	6
Protein PDK4 Interacts with HMGCS2 to Facilitate High Glucoseinduced Myocardial Injuries	6
CXCL13-neutralizing Antibody Alleviate Chronic Skeletal Muscle Degeneration in a Mouse Model	6
Altered Expression of microRNAs in Serum Extracellular Vesicles in Rats with Severe Burns during Shock Stage	6
MicroRNAs in the Pathogenesis of Ankylosing Spondylitis and their Clinical Implication	6
LncRNA-DANCR: A Key Player in Colorectal Cancer Development and Progression	6
Advances in Molecular Biology and Immunology of Spermatozoa and Fertilization in Domestic Animals: Implications for Infertility and Assisted Reproduction	6
Aptamers for Brain Tumors: A Therapeutic Agent for Effectively Crossing the Blood-Brain Barrier	6
The Marine Factor 3,5-dihydroxy-4-methoxybenzyl Alcohol Suppresses Cell Growth, Inflammatory Cytokine Production, and NF-κB Signaling-enhanced Osteoclastogenesis in In vitro Mouse Macrophages RAW264.7	6
Crocetin Suppresses Uterine Ischemia/Reperfusion-induced Inflammation and Apoptosis through the Nrf-2/HO-1 Pathway	6
An Overview of Invasive Ductal Carcinoma (IDC) in Women’s Breast Cancer	6
A Cross-sectional Data Analysis between Serum Total Bilirubin and Potential Obesity Indices in US Adults	6
Emerging Treatment Approaches for COVID-19 Infection: A Critical Review	6
Combinatorial Chemosensitive Nanomedicine Approach for the Treatment of Breast Cancer	6
Iron Overload-induced Ferroptosis as a Target for Protection against Obliterative Bronchiolitis after Orthotopic Tracheal Transplantation in Mice	6
Ferroptosis Inhibitor Regulates the Disease Progression of Systematic Lupus Erythematosus Mice Model Through Th1/Th2 Ratio	6
Nuclear Imaging Modalities in the Diagnosis and Management of Thyroid Cancer	6
Elevation of LEM Domain Containing 1 Predicts Poor Prognosis of NSCLC Patients and Triggers Malignant Stemness and Invasion of NSCLC Cells by Stimulating PI3K/AKT Pathway	5
Microhomology-Mediated Break-Induced Replication: A Possible Molecular Mechanism of the Formation of a Large CNV in FBN1 Gene in a Patient with Marfan Syndrome	5
Gut Microbiota-Induced Long Non-Coding RNA Snhg9 Regulates the Development of Human Malignant Tumors	5
Evaluation of the Safety and Efficacy of Curcumin-Synthesized Silver Nanoparticles in Rats Exposed to Chlorpyrifos During Puberty Development	5
The Role of Bone Morphogenetic Protein 4 in Lung Diseases	5
Role of Mitophagy in Cigarette Smoke-induced Lung Epithelial Cell Injury In Vitro	5
Advances in Exosomal microRNAs and Proteins in Ovarian Cancer Diagnosis, Prognosis, and Treatment	5
Advances in Monoclonal Antibody Therapies for Triple-Negative Breast Cancer: Immunotherapeutic and Targeted Strategies	5
Therapeutic Challenges in COVID-19	5
Covid-19 Prevention and Treatment by Targeting Fc-fusion Proteins: An Experience to Fight Emerging Diseases	5
The Determinative Role of Cytokines in Retinopathy of Prematurity	5
The Role of Retinoblastoma Protein in Cell Cycle Regulation: An Updated Review	5
WITHDRAWN: Nucleic Acid-Based Vaccines Platform Against Covid-19 Pandemic	5
Preface	5
ATF3 Modulates the Proliferation, Migration, and Apoptosis of Synovial Fibroblasts after Arthroscopy by Promoting RGS1 Transcription	5
The Potential Therapeutic Applications of CRISPR/Cas9 in the Treatment of Gastrointestinal Cancers	5
Exosomes Harnessed as Nanocarriers for Cancer Therapy - Current Status and Potential for Future Clinical Applications	5
Analysis of Alternative Splicing Events in Melanoma and their Implications for Prognosis	5
Integrating Traditional Medicine with Conventional Therapies to Combat Tuberculosis: A Comprehensive Review	5
Erucic Acid: A Possible Therapeutic Agent for Neurodegenerative Diseases	5
Development of Tumor Markers for Breast Cancer Immunotherapy	5
Oxidative Stress is a New Avenue for Treatment of Neuropsychiatric Disorders: Hype of Hope?	5
Neurodegenerative Diseases: New Hopes and Perspectives	5
MicroRNAs and their Implications in CD4+ T-cells, Oligodendrocytes and Dendritic Cells in Multiple Sclerosis Pathogenesis	5
Endothelial Progenitor Cell (EPC) is a Prime Target in Diabetic Wound Healing: Mechanisms and Target Therapies	5
Advances in the Study of the Pathogenesis of Vogt-Koyanagi-Harada Syndrome	5
Immune Mechanisms and Related Targets for the Treatment of Fibrosis in Various Organs	5
The Apoptotic, Cytotoxic, and Anti-migration Effects of Sodium Deoxycholate in a Breast Cancer Cell Line and its Modulation on PON1 as a Predictive Risk Marker	5
M1 Macrophage-Derived TNF-α Promotes Pancreatic Cancer Ferroptosis Via p38 MAPK-ACSL4 Pathway	5
TPD52 is a Potential Prognostic Biomarker and Correlated with Immune Infiltration: A Pan-cancer Analysis	5