OOIR: Observatory of International Research

Papers

(The TQCC of Current Molecular Medicine is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Intracellular Ellagic Acid Derived from Goat Urine DMSO Fraction (GUDF) Predicted as an Inhibitor of c-Raf Kinase	229
Exosome-Based Regulation and Therapy in Osteoporosis: Mechanistic Insights and Translational Advances	53
In Transfusion-Dependent Thalassemia Children, Increased Iron Overload is Associated with Lower Serum Alpha-Klotho, Which is Strongly Associated with Lower Total and Ionized Calcium Concentrations	36
Pre-clinical Efficacy and Safety Pharmacology of PEGylated Recombinant Human Endostatin	34
Functional Roles of Non-Coding RNAs in Graves' Disease	33
Altered Expression of TRIM Proteins - Inimical Outcome and Inimitable Oncogenic Function in Breast Cancer with Diverse Carcinogenic Hallmarks	29
Attenuation of NLRP3 Inflammasome by Cigarette Smoke is Correlated with Decreased Defense Response of Oral Epithelial Cells to Candida albicans	29
USP3 inhibition is Active Against Chemo-resistant Hepatocellular Carcinoma Anchorage-independent Growth via Suppressing Wnt/β-catenin	27
Free Radicals and Oxidative Stress: Signaling Mechanisms, Redox Basis for Human Diseases, and Cell Cycle Regulation	27
Sodium Butyrate Pre-Treatment Enhance Differentiation of Bone Marrow Mesenchymal Stem Cells (BM-MSCs) into Hepatocytes and Improve Liver Injury	25
A Mini-Review on Elisa-Based Diagnosis of Schistosomiasis	24
Epigenetic Mechanisms of Antibiotic Resistance	22
Anlotinib Inhibiting Mantle Cell Lymphoma Proliferation and Inducing Apoptosis through PI3K/AKT/mTOR Pathway	22
Ferroptosis and Cancer Immunotherapy	22
Anti-Glioblastoma Effects of Dorzolamide Alone and in Combination with Temozolomide on U87 Cells and CD133+ Glioblastoma Stem Cells	22
Astragalus Mongholicus for Idiopathic Pulmonary Fibrosis Treatment: From Molecules to Systems	22
MicroRNA-Based Biomarkers in Lung Cancer: Recent Advances and Potential Applications	21
The Importance of mir-491-5p in Various Cancers	21
CRISPR-Cas9: A Potent Gene-editing Tool for the Treatment of Cancer	21
NLRP3 Inflammasome Triggers Inflammation of Obstructive Sleep Apnea	20
COL12A1 Promotes Osteosarcoma Progression via the FAK/PI3K/AKT/mTOR Pathway	20
The Role of the TRIM Family in Lung Cancer Development: An Emerging Player with Therapeutic Potential	20
CD4⁺ T-cell Subsets and Cytokine Signature in Pemphigus Foliaceus Clinical Stratification beyond the th1/Th2 Paradigm	19
Follicular Helper T Cells in Peyer's Patches and Galactose- Deficient Iga1 Contribute to Iga Nephropathy	18
Reduction of ACE2 Serum Concentrations by Telbivudine in Chronic Hepatitis B Patients	16

An Updated Review of the Pre-Clinical Role of microRNAs and their Contribution to Colorectal Cancer	15
Study on the Mechanism of Notch Pathway Mediates the Role of Lenvatinib-resistant Hepatocellular Carcinoma Based on Organoids	14
High Glycolysis and Lipid Metabolism Status Predicts Poor Prognosis in Colorectal Cancer Patients	14
Loss of ARHGAP40 in Breast Cancer by Hypermethylation and its Clinical Significance	14
Potential Roles of 5-HT₃ Receptor Antagonists in Reducing Chemotherapy-induced Peripheral Neuropathy (CIPN)	14
Structural and Pharmacological Network Focused on MiRNAs Involved in Rheumatoid Arthritis: A Systematic Review	14
The Mechanosensitive Ion Channel Piezo1 Promotes Obliterative Bronchiolitis through YAP-Dependent Epithelial-to-Mesenchymal Transition	14
Targeting ADAM10 in Renal Diseases	14
Ribosomal DNA and Neurological Disorders	14
ERK/MAPK Signalling Pathway Regulates MMP2 through ETS1 in Renal Clear Cell Carcinoma	13
Broad-Spectrum Vaccines: Challenges and Opportunities (A Systematic Review)	13
Therapeutic Potential of Pistacia Atlantica Gum in Aspirin-Induced Peptic Ulcers: A Dose-Dependent Approach to Mucosal Protection and Hepatorenal Safety	13
SMAC/DIABLO: A Guardian Angel in Boosting Anticancer Drug-Induced Apoptosis	13
Recombinant Unique Cartilage Matrix-associated Protein Potentiates Osteogenic Differentiation and Mineralization of MC3T3-E1 Cells	12
DFT Study of Interaction between Teriflunomide and β-cyclodextrin	12
Physicochemical Stimulus-Responsive Systems Targeted with Antibody Derivatives	12
LKB1 Mutations Enhance Radiosensitivity in Non-Small Cell Lung Cancer Cells by Inducing G2/M Cell Cycle Phase Arrest	12
CsHscB Derived from a Liver Fluke Clonorchis sinensis Ameliorates Cholestatic Hepatic Fibrosis in a Mouse Model of Sclerosing Cholangitis	12
Dexmedetomidine Attenuates Spinal Cord Ischemia-reperfusion Injury in Rabbits by Decreasing Oxidation and Apoptosis	11
Update on Mesenchymal Stem Cells: A Crucial Player in Cancer Immunotherapy	11
Novel Insights of ANGPTL-3 on Modulating Cholesterol Efflux Capacity Induced by HDL Particle	11
Microbiota-driven Immunopathogenesis in Systemic Lupus Erythematosus: Cross-site Mechanisms and Intervention Strategies	11
A Mechanism Study on the Antioxidant Pathway of Keap1-Nrf2- ARE Inhibiting Ferroptosis in Dopaminergic Neurons	11
Combating the Progression of Novel Coronavirus SARS-CoV-2 Infectious Disease: Current State and Future Prospects in Molecular Diagnostics and Drug Discovery	11
HMGB1/RAGE Signaling Regulates Th17/IL-17 and Its Role in Bronchial Epithelial-Mesenchymal Transformation	11
Enhancement of Platinum-based Drug Sensitivity in Ovarian Cancer Cells Through Hyperthermia-induced Activation of the TGF-β1/β-Catenin Signaling Pathway	11
The Role of Hypoxia-inducible Factor-1 in Bladder Cancer	11
Neuroprotective Potential of Hesperidin as Therapeutic Agent in the Treatment of Brain Disorders: Preclinical Evidence-based Review	10
CD155: A Key Receptor Playing Diversified Roles	10
Clock-Sleep Communication	10
The Diagnostic and Prognostic Value of Plasma Circulating CircNUP98 for Nasopharyngeal Carcinoma	10
LINC00665: A Promising Biomarker in Gastrointestinal Tumors	10
Exploring the Gut Microbiota as a Promising Target for Breast Cancer Treatment	10
The Emerging Role of Long Non-coding RNA 01296 in Human Malignancies	10
Astragaloside IV Protects Against IL-1β-Induced Chondrocyte Damage via Activating Autophagy	10
Glaucoma: Biological Mechanism and its Clinical Translation	10
Natural Compounds as Integrative Therapy for Liver Protection against Inflammatory and Carcinogenic Mechanisms: From Induction to Molecular Biology Advancement	10
Role of MicroRNA in Hypoxic Tumours and their Potential as Biomarkers for Early Detection of Cancer	10
Detailed Review of Melatonin and its Role in Managing the Symptoms of Depression	10
Immunohistochemical Analysis of CYP11B2 (Aldosterone Synthase) and Evaluation of the HISTALDO Classification in Patients with Primary Aldosteronism	10
2-DG Promotes the Proliferation, Differentiation, Migration, and Resistance to Oxidative Stress of Mesenchymal Stem Cells through Hippo Signaling	10
Hydroxysafflor Yellow A-Induced Osteoblast Differentiation and Proliferation of BM-MSCs by Up-Regulating Nuclear Vitamin D Receptor	9
Hypoxia Affects Mitochondrial Stress and Facilitates Tumor Metastasis of Colorectal Cancer Through Slug SUMOylation	9
Mesenchymal Stem Cell-derived Exosomes Affect Macrophage Phenotype: A Cell-free Strategy for the Treatment of Skeletal Muscle Disorders	9
Molecular Targeting and Novel Therapeutic Approaches against Fungal Infections	9
Stem Cells as a Novel Source for Regenerative Medicinal Applications in Alzheimer's Disease: An Update	9
Interferon Signature’s Members, a Novel Altered Correlation upon Interferon-β Treatment in Multiple Sclerosis Patients	9
Association between Sputum Culture Conversion and Body Mass Index among Multidrug-Resistant Tuberculosis Patients in Punjab, Pakistan: A Multicenter Retrospective Study	9
Genetic Association Between Sleep Traits and Vertigo Risk:A Two-Sample Bidirectional Mendelian Randomization Study	9
Pharmacological Activation of AMPK Prevents Drp1-mediated Mitochondrial Fission and Alleviates Hepatic Steatosis In vitro	9

Neuroprotective Role of MiRNA-9 in Neurological Diseases: A Mini Review	9
Time- and Concentration-Dependent Stimulation of Oxidative Stress in Chondrocytes by Intracellular Soluble Urate	9
Elucidating the Causal Dynamics between Inflammatory Proteins and Atrial Fibrillation Risk Through Bidirectional Mendelian Randomization	9
Nebulized Inhalation of Bacillus Calmette-Guerin Polysaccharide Nucleic Acid Attenuates Airway Hyperresponsiveness in Asthma by Inhibiting the Notch3/NF-Κb Signaling Pathway to Regulate MUC5AC Express	8
Artificial Intelligence in the Management of One Health: An Update	8
The Association between Cadmium Exposure and Thyroid Function in Animals: A Systematic Review	8
Asiaticoside Prevents Oxidative Stress and Apoptosis in Endothelial Cells by Activating ROS-dependent p53/Bcl-2/Caspase-3 Signaling Pathway	8
Tamoxifen and Colchicine Alter Mitochondrial Respiration to Induce Cell Death in Low-metastatic Breast Cancer Cells	8
CXCL13-neutralizing Antibody Alleviate Chronic Skeletal Muscle Degeneration in a Mouse Model	8
Reversal of Mucin 1 Reduction-Induced Enterocyte Apoptosis by Retinoic Acid through the PI3K/AKT Signaling Pathway in an In vitro Model of Necrotizing Enterocolitis	8
A Cross-sectional Data Analysis between Serum Total Bilirubin and Potential Obesity Indices in US Adults	8
Bioprinting: From Technique to Application in Tissue Engineering and Regenerative Medicine	8
Analysis of Cytokine mRNA Expression During Zika Virus Infection In Mesocricetus auratus	8
Beyond Conventional Therapy: A Comprehensive Review of Herbal, Traditional, and Emerging Interventions for Polycystic Ovary Syndrome	8
ORLNC1 Suppresses Cell Growth in HER2-Positive Breast Cancer via miRNA-296 Sponging	8
Investigation of the Anti-Cancer Effects of Free and PLGA-PAA Encapsulated Hydroxytyrosol on the MCF-7 Breast Cancer Cell Line	8
Emerging Treatment Approaches for COVID-19 Infection: A Critical Review	8
Multiplex PCR System for the Diagnosis of Plague	8
Apolipoprotein A1 Inhibits Adipogenesis Progression of Human Adipose-Derived Mesenchymal Stem Cells	8
Combinatorial Chemosensitive Nanomedicine Approach for the Treatment of Breast Cancer	7
The Marine Factor 3,5-dihydroxy-4-methoxybenzyl Alcohol Suppresses Cell Growth, Inflammatory Cytokine Production, and NF-κB Signaling-enhanced Osteoclastogenesis in In vitro Mouse Macrophages RAW264.7	7
The Apoptotic, Cytotoxic, and Anti-migration Effects of Sodium Deoxycholate in a Breast Cancer Cell Line and its Modulation on PON1 as a Predictive Risk Marker	7
Nuclear Imaging Modalities in the Diagnosis and Management of Thyroid Cancer	7
The Epigenetic Landscape of Hemophilia	7
Protein PDK4 Interacts with HMGCS2 to Facilitate High Glucoseinduced Myocardial Injuries	7
The Diverse Roles of Long Non-Coding RNA HOTTIP in Breast and Gynecological Cancer Progression	7
The Mutational Landscape of Angiosarcoma: Challenges and Opportunities to Design Management Strategies	7
An Overview of Invasive Ductal Carcinoma (IDC) in Women’s Breast Cancer	7
SCH79797, an Antiplatelet Agent, Alleviates Restenosis by Inducing Apoptosis via p53-Mediated Mitochondrial Depolarization and Inhibiting Thrombus Formation after Angioplasty	7
MicroRNAs in the Pathogenesis of Ankylosing Spondylitis and their Clinical Implication	7
Integrating Traditional Medicine with Conventional Therapies to Combat Tuberculosis: A Comprehensive Review	7
Recovery Kinetics and Persistent Hepatic Alterations in a Xenobiotic-induced Murine Model of Chronic Cholestatic Liver Disease	7
VSIG2 Promotes Osteosarcoma Cisplatin Resistance Via Activating PI3K/AKT/mTOR Pathway	7
Advances in Molecular Biology and Immunology of Spermatozoa and Fertilization in Domestic Animals: Implications for Infertility and Assisted Reproduction	7
Dynamin-Related Protein 1 and the NLRP3 Inflammasome in Parkinson's Disease: Mechanistic Insights and Therapeutic Opportunities	7
Crocetin Suppresses Uterine Ischemia/Reperfusion-induced Inflammation and Apoptosis through the Nrf-2/HO-1 Pathway	7
Nanolayered Topsheet Integration for Enhanced Antimicrobial Properties in Sanitary Napkins	7
Aptamers for Brain Tumors: A Therapeutic Agent for Effectively Crossing the Blood-Brain Barrier	7
Current Progress on Neuroinflammation-mediated Postoperative Cognitive Dysfunction: An Update	7
A Systematic Review and Meta-Analysis of Immune Signatures Involved in the Prevalence of Exhaustion in Humans, Mice, and Bovine Species	7
Apolipoprotein A2 Influences ANGPTL3 in Modulating TG Catabolism and Inflammatory Cytokines Secretion	7
miR-34 as a Critical Regulator in Ovarian Cancer	7
WITHDRAWN: LncRNA-PVT1 Inhibition Protects Neuron Injury During Cerebral Ischemia Injury through Targeting the miRNA-187-3p- MyD88 Signaling Pathway	7
LncRNA-DANCR: A Key Player in Colorectal Cancer Development and Progression	7
Advances in the Study of the Pathogenesis of Vogt-Koyanagi- Harada Syndrome	6
Role of Mitophagy in Cigarette Smoke-induced Lung Epithelial Cell Injury In Vitro	6
LncRNA HULC/miR-556-5p Axis Attenuates Ang II-Induced Cardiac Microvascular Endothelial Cell Dysfunction by Suppressing the AMPK/FOXO3 Pathway	6
Evaluation of the Safety and Efficacy of Curcumin-Synthesized Silver Nanoparticles in Rats Exposed to Chlorpyrifos During Puberty Development	6
Analysis of Alternative Splicing Events in Melanoma and the Implications for Prognosis	6
Network-based Transcriptomic Profiling of Fetal Astrocyte Differentiation Reveals Therapeutic Targets for Neurodegenerative Disease	6
Endothelial Progenitor Cell (EPC) is a Prime Target in Diabetic Wound Healing: Mechanisms and Target Therapies	6
Advances in Monoclonal Antibody Therapies for Triple-Negative Breast Cancer: Immunotherapeutic and Targeted Strategies	6
MicroRNAs and their Implications in CD4+ T-cells, Oligodendrocytes and Dendritic Cells in Multiple Sclerosis Pathogenesis	6
Ferroptosis Inhibitor Regulates the Disease Progression of Systematic Lupus Erythematosus Mice Model Through Th1/Th2 Ratio	6
The Potential Therapeutic Applications of CRISPR/Cas9 in the Treatment of Gastrointestinal Cancers	6
Therapeutic Challenges in COVID-19	6
Oxidative Stress is a New Avenue for Treatment of Neuropsychiatric Disorders: Hype of Hope?	6
The Role of Bone Morphogenetic Protein 4 in Lung Diseases	6
Gut Microbiota-Induced Long Non-Coding RNA Snhg9 Regulates the Development of Human Malignant Tumors	6
M1 Macrophage-derived TNF-α Promotes Pancreatic Cancer Ferroptosis via p38 MAPK-ACSL4 Pathway	6
Targeting Ubiquitin-specific Protease 5 Overcomes Chemoresistance via Negatively Regulating p53 in Gastric Cancer	6
Iron Overload-induced Ferroptosis as a Target for Protection against Obliterative Bronchiolitis after Orthotopic Tracheal Transplantation in Mice	6
Advances in Exosomal microRNAs and Proteins in Ovarian Cancer Diagnosis, Prognosis, and Treatment	6
Sulfur Dioxide Inhibits TNF-α-induced Photoreceptor Cell Apoptosis Through Sulfenylation of Caspase-3 at Cysteine 163	6
Microhomology-Mediated Break-Induced Replication: A Possible Molecular Mechanism of the Formation of a Large CNV in FBN1 Gene in a Patient with Marfan Syndrome	6
Neurodegenerative Diseases: New Hopes and Perspectives	6
Alterations in the Expression of Toll-Like Receptors (TLRs) 3, 4, and 7 in Patients with COVID-19: The Role of Disease Severity and Gender	6
ATF3 Modulates the Proliferation, Migration, and Apoptosis of Synovial Fibroblasts after Arthroscopy by Promoting RGS1 Transcription	6