OOIR: Observatory of International Research

Papers

(The TQCC of Current Gene Therapy is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Effective Combination of Single-cell Analysis and Gene Therapy	61
Synergizing CRISPR-Cas9 with Advanced Artificial Intelligence and Machine Learning for Precision Drug Delivery: Technological Nexus and Regulatory Insights	35
The Antimicrobial Peptide Pipeline: A Bacteria-Centric AMP Predictor	25
The Role of RNA m6A Modification in Cancer Glycolytic Reprogramming	22
Immune Modulation Strategies in Gene Therapy: Overcoming Immune Barriers and Enhancing Efficacy	22
Gene Therapy & Cell Therapy	21
Duchenne Muscular Dystrophy Gene Therapy	20
Hutchinson-Gilford Progeria Syndrome: An Overview of the Molecular Mechanism, Pathophysiology and Therapeutic Approach	18
ZNF695, A Potential Prognostic Biomarker, Correlates with Im mune Infiltrates in Cervical Squamous Cell Carcinoma and Endoce rvical Adenocarcinoma: Bioinformatic Analysis and Experimental Verification	17
Riding the Wave of Progress: Examining the Current Landscape and Future Potential of MicroRNAs in Cancer Gene Therapy	15
Effect of Bovine Lactoferrin Treatment on Iron Homeostasis and Gene Expression Changes in Multiple Organ Dysfunctions During Wound Healing Process in Rats	15
Meet the Editorial Board Member	14
Meet the Editorial Board Member	14
Development of Oral Bio-banks Past, Present and Future; Challenges and Opportunities	14
Gene Augmentation Techniques to Stimulate Wound Healing Process: Progress and Prospects	14
Viral Vector Delivery of DREADDs for CNS Therapy	13
Gene Therapy Cargoes Based on Viral Vector Delivery	12
Reversal of Neuropsychiatric Comorbidities in an Animal Model of Temporal Lobe Epilepsy Following Systemic Administration of Dental Pulp Stem Cells and Bone Marrow Mesenchymal Stem Cells	12
Gene Therapy for Critical Limb Ischemia: Per Aspera ad Astra	12
A Hypoxia-Regulated Retinal Pigment Epithelium-Specific Gene Therapy Vector Reduces Choroidal Neovascularization in a Mouse Model	11
Therapeutic Effects of Mesenchymal Stem Cells Expressing Erythropoietin on Cancer-Related Anemia in Mice Model	11
Suppression of mTOR Expression by siRNA Leads to Cell Cycle Arrest and Apoptosis Induction in MDA-MB-231 Breast Cancer Cells	11
Exosomal miRNAs as Next-generation Therapy Vehicles in Breast Cancer	11
Mesenchymal Stromal Cells (MSCs): A Promising Tool for Cell-Based Angiogenic Therapy	10
Inferring Cell-type-specific Genes of Lung Cancer Based on Deep Learning	10

AAV9-coGLB1 Improves Lysosomal Storage and Rescues Central Nervous System Inflammation in a Mutant Mouse Model of GM1 Gangliosidosis	10
The Role of Immunotherapy in Lung Cancer Treatment: Current Strategies, Future Directions, and Insights into Metastasis and Immune Microenvironment	9
CRISPR/Cas System: A Powerful Strategy to Improve Monogenic Human Diseases as Therapeutic Delivery; Current Applications and Challenges	9
Direct Bilirubin, but not Indirect Bilirubin, is Associated with Short-term Adverse Events in HFpEF	8
A Retrospective Analysis of the Lauren Classification in the Choice of XELOX or SOX as an Adjuvant Chemotherapy for Gastric Cancer	8
FIGNL1 Promotes Hepatocellular Carcinoma Formation via Remodeling ECM-receptor Interaction Pathway Mediated by HMMR	8
Recent Progress of Machine Learning in Gene Therapy	8
Gene Therapy of Mucopolysaccharidosis Type I Mice: Repeated Administrations and Safety Assessment of pIDUA/Nanoemulsion Complexes	8
Human Retinal Pigment Epithelial Cells Overexpressing the Neuroprotective Proteins PEDF and GM-CSF to Treat Degeneration of the Neural Retina	8
Gene Therapy in the Anterior Eye Segment	7
Reduced Immunogenicity of Intraparenchymal Delivery of Adeno-Associated Virus Serotype 2 Vectors: Brief Overview	7
Gene Therapy for Chronic Traumatic Brain Injury: Challenges in Resolving Long-term Consequences of Brain Damage	6
Acknowledgements to Reviewers	6
Recent Advances in Predicting Protein-lncRNA Interactions Using Machine Learning Methods	6
Lipid-Based Nanocarriers for Targeted Gene Delivery in Lung Cancer Therapy: Exploring a Novel Therapeutic Paradigm	6
Mechanism of CAV and CAVIN Family Genes in Acute Lung Injury based on DeepGENE	6
DNA Vaccines to Improve Immunogenicity and Effectiveness in Cancer Vaccinations: Advancement and Developments	6
Theranostic Potential of Bacteriophages against Oral Squamous Cell Carcinoma	6
Effective Downregulation of BCR-ABL Tumorigenicity by RNA Targeted CRISPR-Cas13a	6
Effectiveness and Application Prospect of Microbiota-based Treatment	6
Gene Therapy for Skin Aging	5
Teratogenic Toxicity Evaluation of Bladder Cancer-Specific Oncolytic Adenovirus on Mice	5
Applications of L-Arginine in Pregnancy and Beyond: An Emerging Pharmacogenomic Approach	5
Hemophilia Healing with AAV: Navigating the Frontier of Gene Therapy	5