OOIR: Observatory of International Research

Papers

(The TQCC of Current Gene Therapy is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Effective Combination of Single-cell Analysis and Gene Therapy	75
A Retrospective Analysis of the Lauren Classification in the Choice of XELOX or SOX as an Adjuvant Chemotherapy for Gastric Cancer	39
Synergizing CRISPR-Cas9 with Advanced Artificial Intelligence and Machine Learning for Precision Drug Delivery: Technological Nexus and Regulatory Insights	32
A Comprehensive Review of Genetic Risk Factors for Alzheimer’s Disease Development	30
Identifying ARRB2 as a Prognostic Biomarker and Key Player in the Tumor Microenvironment of Pancreatic Cancer through scPagwas Methodology	27
Gene Augmentation Techniques to Stimulate Wound Healing Process: Progress and Prospects	25
Next-Generation Whole-Exome Pattern: Advanced Methods and ClinicalSignificance	23
Acknowledgements to Reviewers	20
DNA Vaccines to Improve Immunogenicity and Effectiveness in Cancer Vaccinations: Advancement and Developments	20
Mesenchymal Stromal Cells (MSCs): A Promising Tool for Cell-Based Angiogenic Therapy	20
Therapeutic Potential of POU3F3, a Novel Long Non-coding RNA, Alleviates the Pathogenesis of Osteoarthritis by Regulating the miR-29a- 3p/FOXO3 Axis	18
MDAlmc: A Novel Low-rank Matrix Completion Model for MiRNADisease Association Prediction by Integrating Similarities among MiRNAs and Diseases	18
Applications of L-Arginine in Pregnancy and Beyond: An Emerging Pharmacogenomic Approach	18
Comprehensive Analysis and Experimental Validation of HEPACAM2 as a Potential Prognosis Biomarker and Immunotherapy Target in Colorectal Cancer	16
In Situ Gene Therapy	16
Identification and Validation of Amino Acid Metabolism-Related Biomarkers and Investigation of their Potential Mechanisms in Lung Adenocarcinoma	13
Human Virus-Like Proteins: Implications for Gene Therapy	12
The Role of Myeloid-derived Suppressor Cells and Non-tumor Cells in theGlioma Microenvironment	12
Harnessing Nanotechnology and Gene Editing for Cancer Therapy: ASynergistic Approach to Precision Medicine	12
TRPM8 as a Potential Biomarker and Therapeutic Target for Gastric Cancer Identified by a Combination of Text Mining and RNA Sequencing	11
Gene Therapy Based on Lipid Nanoparticles as Non-viral Vectors for Glioma Treatment	11
A Complete Sojourn of Gene Therapy along with its Targeting Approaches for the Treatment of the Major Depressive Disorder	11
Probing the Depths of Molecular Complexity: STAT3 as a Key Architect in Colorectal Cancer Pathogenesis	10
From DNA Editing to RNA Regulation: The Breakthroughs of CRISPR and Mega-CRISPR	10
Role of Long Non-Coding RNA in Regulating ER Stress Response to the Progression of Diabetic Complications	10

Significance of Ribonucleoside-diphosphate Reductase Subunit M2 in Lung Adenocarcinoma	10
Anesthesia and Cancer: Something More than Avoiding Stress Response	10
Lentiviral Micro-dystrophin Gene Treatment into Late-stage mdx Mice for Duchenne Muscular Dystrophy Disease	9
Corrigendum to: Neuroprotection by Human Dental Pulp Mesenchymal Stem Cells: From Billions to Nano	9
Gene Therapy & Cell Therapy	8
Therapeutic Effects of Mesenchymal Stem Cells Expressing Erythropoietin on Cancer-Related Anemia in Mice Model	8
Therapeutic Effects of Mesenchymal Stem Cells Carrying Echovirus inMouse Models of Breast Cancer	8
Effect of Bovine Lactoferrin Treatment on Iron Homeostasis and Gene Expression Changes in Multiple Organ Dysfunctions During Wound Healing Process in Rats	8
Mechanism of CAV and CAVIN Family Genes in Acute Lung Injury based on DeepGENE	8
A Hypoxia-Regulated Retinal Pigment Epithelium-Specific Gene Therapy Vector Reduces Choroidal Neovascularization in a Mouse Model	8
Gene Therapy for Chronic Traumatic Brain Injury: Challenges in Resolving Long-term Consequences of Brain Damage	8
Reduced Immunogenicity of Intraparenchymal Delivery of Adeno-Associated Virus Serotype 2 Vectors: Brief Overview	7
Hemophilia Healing with AAV: Navigating the Frontier of Gene Therapy	7
The Mitochondrial Deoxyribonucleic Acid Puzzle: Controversies, Challenges, and Critical Perspectives A Narrative Review	7
Splicing DNA Damage Adaptations for the Management of Cancer Cells	7
HCST Expression Distinguishes Immune-hot and Immune-cold Subtypes in Pancreatic Ductal Adenocarcinoma	6
Synergistic Antiproliferative Effects of EGCG and Myricetin on Cervical Cancer Biomarkers in ME180 and SiHa Cell Lines	6
Biogenesis and Function of circRNAs in Pulmonary Fibrosis	6
Revolution of Traditional Chinese Medicine in Anticancer Therapy, Applications and Future Perspective	6
Gene Therapy for Rare Genetic Diseases	6
Prediction of SARS-CoV-2 Infection Phosphorylation Sites and Associations of these Modifications with Lung Cancer Development	5
A Paradigm Shift in Hemophilia Care: The Promise of Gene Therapy	5
Untangling the Genetic Threads of Alzheimer's: Insights into Risk Factors and Biomarkers	5
Computational Analysis Illustrates the Mechanism of Qingfei Paidu Decoction in Blocking the Transition of COVID-19 Patients from Mild to Severe Stage	5
Pan-Cancer Single-Cell Analysis Revealing the Heterogeneity of Cancer- Associated Fibroblasts in Skin Tumors	5
Segmentation of Thoracic Organs through Distributed Extraction of Visual Feature Patterns Utilizing Resio-Inception U-Net and Deep Cluster Recognition Techniques	5
Novel Perspective of Regulating P53/Bcl2/Caspase-3 via In vitro Targeted AFP Gene Knocks Out in HepG2 Cells Using CRISPR/Cas9 Editing Tool	5
Non-coding RNAs in Regulation of Protein Aggregation and Clearance Pathways: Current Perspectives Towards Alzheimer's Research and Therapy	5
Single-cell and Bulk Transcriptomic Analyses Reveal a Stemness and Circadian Rhythm Disturbance-related Signature Predicting Clinical Outcome and Immunotherapy Response in Hepatocellular Carcinoma	5
Role of Exosomal miRNAs and Epigenetic Modifications in Diabetic Nephropathy: Insights into Novel Diagnostic and Therapeutic Strategies	5