OOIR: Observatory of International Research

Papers

(The TQCC of Current Gene Therapy is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
A Retrospective Analysis of the Lauren Classification in the Choice of XELOX or SOX as an Adjuvant Chemotherapy for Gastric Cancer	62
Effective Combination of Single-cell Analysis and Gene Therapy	36
Gene Augmentation Techniques to Stimulate Wound Healing Process: Progress and Prospects	30
Synergizing CRISPR-Cas9 with Advanced Artificial Intelligence and Machine Learning for Precision Drug Delivery: Technological Nexus and Regulatory Insights	24
Next-Generation Whole-Exome Pattern: Advanced Methods and Clinical Significance	23
Mesenchymal Stromal Cells (MSCs): A Promising Tool for Cell-Based Angiogenic Therapy	22
DNA Vaccines to Improve Immunogenicity and Effectiveness in Cancer Vaccinations: Advancement and Developments	20
Acknowledgements to Reviewers	20
Applications of L-Arginine in Pregnancy and Beyond: An Emerging Pharmacogenomic Approach	19
Comprehensive Analysis and Experimental Validation of HEPACAM2 as a Potential Prognosis Biomarker and Immunotherapy Target in Colorectal Cancer	18
Therapeutic Potential of POU3F3, a Novel Long Non-coding RNA, Alleviates the Pathogenesis of Osteoarthritis by Regulating the miR-29a- 3p/FOXO3 Axis	17
Identification and Validation of Amino Acid Metabolism-Related Biomarkers and Investigation of their Potential Mechanisms in Lung Adenocarcinoma	16
In Situ Gene Therapy	15
MDAlmc: A Novel Low-rank Matrix Completion Model for MiRNADisease Association Prediction by Integrating Similarities among MiRNAs and Diseases	15
TRPM8 as a Potential Biomarker and Therapeutic Target for Gastric Cancer Identified by a Combination of Text Mining and RNA Sequencing	14
Gene Therapy Based on Lipid Nanoparticles as Non-viral Vectors for Glioma Treatment	14
Single-cell RNA Sequencing Analysis Identifies Key Genes in Brain Metastasis from Lung Adenocarcinoma	13
The Role of Myeloid-derived Suppressor Cells and Non-tumor Cells in the Glioma Microenvironment	13
Human Virus-Like Proteins: Implications for Gene Therapy	12
Anesthesia and Cancer: Something More than Avoiding Stress Response	12
A Complete Sojourn of Gene Therapy along with its Targeting Approaches for the Treatment of the Major Depressive Disorder	12
Lentiviral Micro-dystrophin Gene Treatment into Late-stage mdx Mice for Duchenne Muscular Dystrophy Disease	11
Significance of Ribonucleoside-diphosphate Reductase Subunit M2 in Lung Adenocarcinoma	11
From DNA Editing to RNA Regulation: The Breakthroughs of CRISPR and Mega-CRISPR	11
Probing the Depths of Molecular Complexity: STAT3 as a Key Architect in Colorectal Cancer Pathogenesis	10

Role of Long Non-Coding RNA in Regulating ER Stress Response to the Progression of Diabetic Complications	10
Therapeutic Effects of Mesenchymal Stem Cells Expressing Erythropoietin on Cancer-Related Anemia in Mice Model	9
Corrigendum to: Neuroprotection by Human Dental Pulp Mesenchymal Stem Cells: From Billions to Nano	9
A Hypoxia-Regulated Retinal Pigment Epithelium-Specific Gene Therapy Vector Reduces Choroidal Neovascularization in a Mouse Model	9
Mechanism of CAV and CAVIN Family Genes in Acute Lung Injury based on DeepGENE	8
Effect of Bovine Lactoferrin Treatment on Iron Homeostasis and Gene Expression Changes in Multiple Organ Dysfunctions During Wound Healing Process in Rats	8
Gene Therapy & Cell Therapy	8
Gene Therapy for Chronic Traumatic Brain Injury: Challenges in Resolving Long-term Consequences of Brain Damage	8
Reduced Immunogenicity of Intraparenchymal Delivery of Adeno-Associated Virus Serotype 2 Vectors: Brief Overview	8
Splicing DNA Damage Adaptations for the Management of Cancer Cells	8
Hemophilia Healing with AAV: Navigating the Frontier of Gene Therapy	7
Non-coding RNAs in Regulation of Protein Aggregation and Clearance Pathways: Current Perspectives Towards Alzheimer's Research and Therapy	7
Segmentation of Thoracic Organs through Distributed Extraction of Visual Feature Patterns Utilizing Resio-Inception U-Net and Deep Cluster Recognition Techniques	7
Single-cell and Bulk Transcriptomic Analyses Reveal a Stemness and Circadian Rhythm Disturbance-related Signature Predicting Clinical Outcome and Immunotherapy Response in Hepatocellular Carcinoma	6
Efficacy of Gene Therapy to Restore Cognition in Alzheimer’s Disease: A Systematic Review	6
Gene Therapy for Rare Genetic Diseases	6
Computational Analysis Illustrates the Mechanism of Qingfei Paidu Decoction in Blocking the Transition of COVID-19 Patients from Mild to Severe Stage	6
Pan-Cancer Single-Cell Analysis Revealing the Heterogeneity of Cancer-Associated Fibroblasts in Skin Tumors	6
Biogenesis and Function of circRNAs in Pulmonary Fibrosis	6
HCST Expression Distinguishes Immune-hot and Immune-cold Subtypes in Pancreatic Ductal Adenocarcinoma	6
Prediction of SARS-CoV-2 Infection Phosphorylation Sites and Associations of these Modifications with Lung Cancer Development	6
Dissecting the Mechanisms of Intestinal Immune Homeostasis by Analyzing T-Cell Immune Response in Crohn's Disease and Colorectal Cancer	5
MicroRNAs: A Critical Regulator and a Promising Therapeutic and Diagnostic Molecule for Diabetic Cardiomyopathy	4
CRISPR/Cas System: A Powerful Strategy to Improve Monogenic Human Diseases as Therapeutic Delivery; Current Applications and Challenges	4
Hereditary Patterns and Genetic Associations in Obsessive-Compulsive Disorder (OCD): Neuropsychiatric Insights, Genetic Influences, and Treatment Perspectives	4
Single Injection AAV2-FGF18 Gene Therapy Reduces Cartilage Loss and Subchondral Bone Damage in a Mechanically Induced Model of Osteoarthritis	4
Untangling the Genetic Threads of Alzheimer's: Insights into Risk Factors and Biomarkers	4
Reversal of Neuropsychiatric Comorbidities in an Animal Model of Temporal Lobe Epilepsy Following Systemic Administration of Dental Pulp Stem Cells and Bone Marrow Mesenchymal Stem Cells	4
The Role of Immunotherapy in Lung Cancer Treatment: Current Strategies, Future Directions, and Insights into Metastasis and Immune Microenvironment	4
Targeting of Ykl-40 as a Protumor in Personalized Medicine: A New Dimension in Disease Understanding	4
Knockdown of hsa_circ_0102231 Impedes the Progression of Liver Cancer through the miR-873–SOX4 Axis	4
AEG-1 as a Novel Therapeutic Target in Colon Cancer: A Study from Silencing AEG-1 in BALB/c Mice to Large Data Analysis	4
FIGNL1 Promotes Hepatocellular Carcinoma Formation via Remodeling ECM-receptor Interaction Pathway Mediated by HMMR	4
The Role of RNA m6A Modification in Cancer Glycolytic Reprogramming	4
Immune Modulation Strategies in Gene Therapy: Overcoming Immune Barriers and Enhancing Efficacy	4
CRISPR/Cas9 Technology for Modifying Immune Checkpoint in CAR-T Cell Therapy for Hematopoietic Malignancies	4
Current Updates on the Role of MicroRNA in the Diagnosis and Treatment of Neurodegenerative Diseases	4
Efficacy and Safety of Pembrolizumab Monotherapy or Combined Therapy in Patients with Metastatic Triple-negative Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials	4
Acknowledgements to Reviewers	4