OOIR: Observatory of International Research

Papers

(The TQCC of Current Gene Therapy is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
A Retrospective Analysis of the Lauren Classification in the Choice of XELOX or SOX as an Adjuvant Chemotherapy for Gastric Cancer	70
Effective Combination of Single-cell Analysis and Gene Therapy	38
Synergizing CRISPR-Cas9 with Advanced Artificial Intelligence and Machine Learning for Precision Drug Delivery: Technological Nexus and Regulatory Insights	31
Gene Augmentation Techniques to Stimulate Wound Healing Process: Progress and Prospects	30
Next-Generation Whole-Exome Pattern: Advanced Methods and Clinical Significance	25
Mesenchymal Stromal Cells (MSCs): A Promising Tool for Cell-Based Angiogenic Therapy	24
DNA Vaccines to Improve Immunogenicity and Effectiveness in Cancer Vaccinations: Advancement and Developments	24
Applications of L-Arginine in Pregnancy and Beyond: An Emerging Pharmacogenomic Approach	20
Acknowledgements to Reviewers	20
Identification and Validation of Amino Acid Metabolism-Related Biomarkers and Investigation of their Potential Mechanisms in Lung Adenocarcinoma	20
In Situ Gene Therapy	19
Comprehensive Analysis and Experimental Validation of HEPACAM2 as a Potential Prognosis Biomarker and Immunotherapy Target in Colorectal Cancer	17
Therapeutic Potential of POU3F3, a Novel Long Non-coding RNA, Alleviates the Pathogenesis of Osteoarthritis by Regulating the miR-29a- 3p/FOXO3 Axis	17
MDAlmc: A Novel Low-rank Matrix Completion Model for MiRNADisease Association Prediction by Integrating Similarities among MiRNAs and Diseases	17
TRPM8 as a Potential Biomarker and Therapeutic Target for Gastric Cancer Identified by a Combination of Text Mining and RNA Sequencing	16
Gene Therapy Based on Lipid Nanoparticles as Non-viral Vectors for Glioma Treatment	15
The Role of Myeloid-derived Suppressor Cells and Non-tumor Cells in the Glioma Microenvironment	15
Human Virus-Like Proteins: Implications for Gene Therapy	14
Single-cell RNA Sequencing Analysis Identifies Key Genes in Brain Metastasis from Lung Adenocarcinoma	13
Significance of Ribonucleoside-diphosphate Reductase Subunit M2 in Lung Adenocarcinoma	12
A Complete Sojourn of Gene Therapy along with its Targeting Approaches for the Treatment of the Major Depressive Disorder	12
From DNA Editing to RNA Regulation: The Breakthroughs of CRISPR and Mega-CRISPR	12
Anesthesia and Cancer: Something More than Avoiding Stress Response	12
Lentiviral Micro-dystrophin Gene Treatment into Late-stage mdx Mice for Duchenne Muscular Dystrophy Disease	11
Corrigendum to: Neuroprotection by Human Dental Pulp Mesenchymal Stem Cells: From Billions to Nano	11

Role of Long Non-Coding RNA in Regulating ER Stress Response to the Progression of Diabetic Complications	11
Therapeutic Effects of Mesenchymal Stem Cells Expressing Erythropoietin on Cancer-Related Anemia in Mice Model	10
A Hypoxia-Regulated Retinal Pigment Epithelium-Specific Gene Therapy Vector Reduces Choroidal Neovascularization in a Mouse Model	10
Probing the Depths of Molecular Complexity: STAT3 as a Key Architect in Colorectal Cancer Pathogenesis	10
Therapeutic Effects of Mesenchymal Stem Cells Carrying Echovirus in Mouse Models of Breast Cancer	9
Gene Therapy & Cell Therapy	9
Effect of Bovine Lactoferrin Treatment on Iron Homeostasis and Gene Expression Changes in Multiple Organ Dysfunctions During Wound Healing Process in Rats	9
Mechanism of CAV and CAVIN Family Genes in Acute Lung Injury based on DeepGENE	9
Gene Therapy for Chronic Traumatic Brain Injury: Challenges in Resolving Long-term Consequences of Brain Damage	8
Reduced Immunogenicity of Intraparenchymal Delivery of Adeno-Associated Virus Serotype 2 Vectors: Brief Overview	8
The Mitochondrial Deoxyribonucleic Acid Puzzle: Controversies, Challenges, and Critical Perspectives – A Narrative Review	8
Splicing DNA Damage Adaptations for the Management of Cancer Cells	8
Biogenesis and Function of circRNAs in Pulmonary Fibrosis	8
Hemophilia Healing with AAV: Navigating the Frontier of Gene Therapy	8
Gene Therapy for Rare Genetic Diseases	7
HCST Expression Distinguishes Immune-hot and Immune-cold Subtypes in Pancreatic Ductal Adenocarcinoma	7
Prediction of SARS-CoV-2 Infection Phosphorylation Sites and Associations of these Modifications with Lung Cancer Development	7
Non-coding RNAs in Regulation of Protein Aggregation and Clearance Pathways: Current Perspectives Towards Alzheimer's Research and Therapy	6
Pan-Cancer Single-Cell Analysis Revealing the Heterogeneity of Cancer-Associated Fibroblasts in Skin Tumors	6
Computational Analysis Illustrates the Mechanism of Qingfei Paidu Decoction in Blocking the Transition of COVID-19 Patients from Mild to Severe Stage	6
Single-cell and Bulk Transcriptomic Analyses Reveal a Stemness and Circadian Rhythm Disturbance-related Signature Predicting Clinical Outcome and Immunotherapy Response in Hepatocellular Carcinoma	6
Novel Perspective of Regulating P53/Bcl2/Caspase-3 via In vitro Targeted AFP Gene Knocks Out in HepG2 Cells Using CRISPR/Cas9 Editing Tool	6
CRISPR/Cas9 Technology for Modifying Immune Checkpoint in CAR-T Cell Therapy for Hematopoietic Malignancies	5
Dissecting the Mechanisms of Intestinal Immune Homeostasis by Analyzing T-Cell Immune Response in Crohn's Disease and Colorectal Cancer	5
Immunoinformatic Based Designing of Immune Boosting and Nonallergenic Multi-epitope Subunit Vaccine Against the Enterovirus D68	5
Segmentation of Thoracic Organs through Distributed Extraction of Visual Feature Patterns Utilizing Resio-Inception U-Net and Deep Cluster Recognition Techniques	5
Untangling the Genetic Threads of Alzheimer's: Insights into Risk Factors and Biomarkers	5