OOIR: Observatory of International Research

Papers

(The median citation count of Current Gene Therapy is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
miRNA-146a Improves Immunomodulatory Effects of MSC-derived Exosomes in Rheumatoid Arthritis	62
The Emerging Role of Stem Cells in Regenerative Dentistry	42
Gene Therapy in the Anterior Eye Segment	35
Integrated Analysis of mRNA-seq and miRNA-seq to Identify c-MYC, YAP1 and miR-3960 as Major Players in the Anticancer Effects of Caffeic Acid Phenethyl Ester in Human Small Cell Lung Cancer Cell Line	33
Applications of Recombinant Adenovirus-p53 Gene Therapy for Cancers in the Clinic in China	31
CD24, A Review of its Role in Tumor Diagnosis, Progression and Therapy	22
Exosomes: Structure, Biogenesis, Types and Application in Diagnosis and Gene and Drug Delivery	22
Strategic Developments & Future Perspective on Gene Therapy for Breast Cancer: Role of mTOR and Brk/ PTK6 as Molecular Targets	21
Gene Therapy, A Novel Therapeutic Tool for Neurological Disorders: Current Progress, Challenges and Future Prospective	20
Gene Therapy Approaches in an Autoimmune Demyelinating Disease: Multiple Sclerosis	18
Inferring Cell-type-specific Genes of Lung Cancer Based on Deep Learning	15
Single-cell RNA Sequencing Analysis Identifies Key Genes in Brain Metastasis from Lung Adenocarcinoma	14
Computational Analysis Illustrates the Mechanism of Qingfei Paidu Decoction in Blocking the Transition of COVID-19 Patients from Mild to Severe Stage	13
Hutchinson-Gilford Progeria Syndrome: An Overview of the Molecular Mechanism, Pathophysiology and Therapeutic Approach	13
Molecular Genetics of Early- and Late-Onset Alzheimer’s Disease	13
Combined Analysis of Clinical Data on HGF Gene Therapy to Treat Critical Limb Ischemia in Japan	12
A Five-gene Signature for Predicting the Prognosis of Colorectal Cancer	11
Recent Progress of Machine Learning in Gene Therapy	11
Artificial RNA Editing with ADAR for Gene Therapy	11
Mesenchymal Stem Cells Promote Caspase Expression in Molt-4 Leukemia Cells Via GSK-3α/Β and ERK1/2 Signaling Pathways as a Therapeutic Strategy	11
Promising Gene Therapy Using an Adenovirus Vector Carrying REIC/Dkk-3 Gene for the Treatment of Biliary Cancer	11
Identification of Chronic Hypersensitivity Pneumonitis Biomarkers with Machine Learning and Differential Co-expression Analysis	10
miR-1-3p/CELSR3 Participates in Regulating Malignant Phenotypes of Lung Adenocarcinoma Cells	10
Gene Therapy for Angelman Syndrome: Contemporary Approaches and Future Endeavors	10
Feasibility of Mesenchymal Stem Cell Therapy for COVID-19: A Mini Review	10

Recent Advances in Predicting Protein-lncRNA Interactions Using Machine Learning Methods	10
Stem Cell Transplantation Improves Ovarian Function through Paracrine Mechanisms	10
miR-375 Inhibits the Proliferation, Migration and Invasion of Esophageal Squamous Cell Carcinoma by Targeting XPR1	10
CAR-NK Cells for Cancer Therapy: Molecular Redesign of the Innate Antineoplastic Response	10
Systemic Therapy for Hepatocellular Carcinoma: Advances and Hopes	10
Gene Therapy Based on Lipid Nanoparticles as Non-viral Vectors for Glioma Treatment	10
Potential Prognostic Predictors and Molecular Targets for Skin Melanoma Screened by Weighted Gene Co-expression Network Analysis	9
Omics Data and Artificial Intelligence: New Challenges for Gene Therapy	9
Gene Therapy in the Management of Parkinson’s Disease: Potential of GDNF as a Promising Therapeutic Strategy	9
Exploring the Role of Gene Therapy for Neurological Disorders	9
MicroRNAs: A Critical Regulator and a Promising Therapeutic and Diagnostic Molecule for Diabetic Cardiomyopathy	9
Predicting LncRNA-Disease Association Based on Generative Adversarial Network	9
Mesenchymal Stromal Cells (MSCs): A Promising Tool for Cell-Based Angiogenic Therapy	9
NF1, Neurofibromin and Gene Therapy: Prospects of Next-Generation Therapy	8
Current Landscape and Emerging Opportunities of Gene Therapy with Non-viral Episomal Vectors	8
Effect of Rat Bone Marrow Derived-Mesenchymal Stem Cells on Granulocyte Differentiation of Mononuclear Cells as Preclinical Agent in Cellbased Therapy	8
The Effectiveness of Nanoparticles on Gene Therapy for Glioblastoma Cells Apoptosis: A Systematic Review	8
Cancer Treatment Evolution from Traditional Methods to Stem Cells and Gene Therapy	8
Potential Non-coding RNAs from Microorganisms and their Therapeutic Use in the Treatment of Different Human Cancers	8
Therapeutic Potential of POU3F3, a Novel Long Non-coding RNA, Alleviates the Pathogenesis of Osteoarthritis by Regulating the miR-29a- 3p/FOXO3 Axis	8
Popularizing Recombinant Baculovirus-derived OneBac System for Laboratory Production of all Recombinant Adeno-associated Virus Vector Serotypes	7
Promising Anti-stroke Signature of Voglibose: Investigation through In- Silico Molecular Docking and Virtual Screening in In-Vivo Animal Studies	7
γ-Aminobutyric Acid Promotes Osteogenic Differentiation of Mesenchymal Stem Cells by Inducing TNFAIP3	7
Gene Therapy for Hemophilia A: Where We Stand	7
CRISPR Systems Suitable for Single AAV Vector Delivery	7
Delivery Systems for RNA Interference Therapy: Current Technologies and Limitations	7
Therapeutic Approaches for the Management of Autoimmune Disorders via Gene Therapy: Prospects, Challenges and Opportunities	7
Genetically-modified Stem Cell in Regenerative Medicine and Cancer Therapy; A New Era	7
Gene Therapy Repairs for the Epileptic Brain: Potential for Treatment and Future Directions	6
Current Designs of Polymeric Platforms Towards the Delivery of Nucleic Acids Inside the Cells with Focus on Polyethylenimine	6
CRISPR/Cas9 Technology as a Modern Genetic Manipulation Tool for Recapitulating of Neurodegenerative Disorders in Large Animal Models	6
Human Retinal Pigment Epithelial Cells Overexpressing the Neuroprotective Proteins PEDF and GM-CSF to Treat Degeneration of the Neural Retina	6
The Dramatic Role of IFN Family in Aberrant Inflammatory Osteolysis	6
Teratogenic Toxicity Evaluation of Bladder Cancer-Specific Oncolytic Adenovirus on Mice	6
Nanoparticle Based Gene Therapy Approach: A Pioneering Rebellion in the Management of Psychiatric Disorders	6
Prader-Willi Syndrome: Molecular Mechanism and Epigenetic Therapy	6
TGF-β1-based CRISPR/Cas9 Gene Therapy Attenuates Radiation-induced Lung Injury	5
Gene Therapy Cargoes Based on Viral Vector Delivery	5
Poly(rC) Binding Protein 1 Represses the Translation of STAT3 through 5' UTR	5
Gene Therapy, A Potential Therapeutic Tool for Neurological and Neuropsychiatric Disorders: Applications, Challenges and Future Perspective	5
AAV9-coGLB1 Improves Lysosomal Storage and Rescues Central Nervous System Inflammation in a Mutant Mouse Model of GM1 Gangliosidosis	5
Overexpressing Runx2 of BMSCs Improves the Repairment of knee Cartilage Defects	5
CRISPR/Cas9 Genome Editing Tool: A Promising Tool for Therapeutic Applications on Respiratory Diseases	5
New Hope for Intervertebral Disc Degeneration: Bone Marrow Mesenchymal Stem Cells and Exosomes Derived from Bone Marrow Mesenchymal Stem Cell Transplantation	4
Identification and Analysis of RNA Editing Events in Ovarian Serous Cystadenoma Using RNA-seq Data	4
Effective Downregulation of BCR-ABL Tumorigenicity by RNA Targeted CRISPR-Cas13a	4
Epigenetic Modifications in Acute Lymphoblastic Leukemia: From Cellular Mechanisms to Therapeutics	4
Limb-girdle Muscular Dystrophy and Therapy: Insights into Cell and Gene-based Approaches	4
Transfection of TGF-β shRNA by Using Ultrasound-targeted Microbubble Destruction to Inhibit the Early Adhesion Repair of Rats Wounded Achilles Tendon In vitro and In vivo	4
Newly Designed Decellularized Scaffolds for Scaffold-based Gene Therapy from Elastic Cartilages via Supercritical Carbon Dioxide Fluid and Alkaline/ Protease Treatments	4

Treatment of GM2 Gangliosidosis in Adult Sandhoff Mice Using an Intravenous Self-Complementary Hexosaminidase Vector	4
Recombinant Human p53 Adenovirus Injection (rAd-p53) Combined with Chemotherapy for 4 Cases of High-grade Serous Ovarian Cancer	4
Gene Therapy Strategies for Glaucomatous Neurodegeneration	4
The Role of RNA m6A Modification in Cancer Glycolytic Reprogramming	4
Identification of Gene Signature Associated with Type 2 Diabetes Mellitus by Integrating Mutation and Expression Data	4
Clinical Development of Cell Therapies to Halt Lysosomal Storage Diseases: Results and Lessons Learned	4
Effect of Proteasome Inhibitors on the AAV-Mediated Transduction Efficiency in Retinal Bipolar Cells	4
Exosomal miRNAs as Next-generation Therapy Vehicles in Breast Cancer	4
Viral Vector Delivery of DREADDs for CNS Therapy	4
Duchenne Muscular Dystrophy Gene Therapy	3
In-silico Molecular Interaction of Short Synthetic Lipopeptide/Importin-alpha and In-vitro Evaluation of Transgene Expression Mediated by Liposome- Based Gene Carrier	3
Targeted Delivery for Neurodegenerative Disorders Using Gene Therapy Vectors: Gene Next Therapeutic Goals	3
Genetic Engineering of AAV Capsid Gene for Gene Therapy Application	3
In Situ Gene Therapy	3
A Hypoxia-Regulated Retinal Pigment Epithelium-Specific Gene Therapy Vector Reduces Choroidal Neovascularization in a Mouse Model	3
The Effects of Human Umbilical Cord Mesenchymal Stem Cell Transplantation on Female Fertility Restoration in Mice	3
Nanoparticle-Based Gene Therapy Intervention for Stroke Treatment: A Systematic Review	3
Evaluation of BMP-2 Minicircle DNA for Enhanced Bone Engineering and Regeneration	3
Recombinant Adeno-associated Virus 9-mediated Expression of Kallistatin Suppresses Lung Tumor Growth in Mice	3
Exosomal MiR-29a in Cardiomyocytes Induced by Angiotensin II Regulates Cardiac Microvascular Endothelial Cell Proliferation, Migration and Angiogenesis by Targeting VEGFA	3
Gene Therapy of Mucopolysaccharidosis Type I Mice: Repeated Administrations and Safety Assessment of pIDUA/Nanoemulsion Complexes	3
Cytoplasmic Trafficking of Nanoparticles Delivers Plasmid DNA for Macrophage Gene-editing	3
Prospects of Non-Coding Elements in Genomic DNA Based Gene Therapy	3
Mesenchymal Stem Cells: A New Generation of Therapeutic Agents as Vehicles in Gene Therapy	3