OOIR: Observatory of International Research

Papers

(The median citation count of Current Gene Therapy is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Effective Combination of Single-cell Analysis and Gene Therapy	47
Gene Augmentation Techniques to Stimulate Wound Healing Process: Progress and Prospects	33
A Comprehensive Review of Genetic Risk Factors for Alzheimer’s Disease Development	33
Next-Generation Whole-Exome Pattern: Advanced Methods and Clinical Significance	32
Identifying ARRB2 as a Prognostic Biomarker and Key Player in the Tumor Microenvironment of Pancreatic Cancer through scPagwas Methodology	28
Evaluation of the Cellular Effects of miR-30d-3p in A549 Cells Under Normoxic and Hypoxic Conditions	26
Synergizing CRISPR-Cas9 with Advanced Artificial Intelligence and Machine Learning for Precision Drug Delivery: Technological Nexus and Regulatory Insights	25
Identifying Key Epigenetic Modification-Related Genes for Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma and Cellular Validation	25
A Retrospective Analysis of the Lauren Classification in the Choice of XELOX or SOX as an Adjuvant Chemotherapy for Gastric Cancer	23
Acknowledgements to Reviewers	22
Applications of L-Arginine in Pregnancy and Beyond: An Emerging Pharmacogenomic Approach	22
Identification and Validation of Amino Acid Metabolism-Related Biomarkers and Investigation of their Potential Mechanisms in Lung Adenocarcinoma	21
DNA Vaccines to Improve Immunogenicity and Effectiveness in Cancer Vaccinations: Advancement and Developments	21
Therapeutic Potential of POU3F3, a Novel Long Non-coding RNA, Alleviates the Pathogenesis of Osteoarthritis by Regulating the miR-29a- 3p/FOXO3 Axis	21
MDAlmc: A Novel Low-rank Matrix Completion Model for MiRNADisease Association Prediction by Integrating Similarities among MiRNAs and Diseases	21
Comprehensive Analysis and Experimental Validation of HEPACAM2 as a Potential Prognosis Biomarker and Immunotherapy Target in Colorectal Cancer	20
Human Virus-Like Proteins: Implications for Gene Therapy	20
Harnessing Nanotechnology and Gene Editing for Cancer Therapy: ASynergistic Approach to Precision Medicine	18
TRPM8 as a Potential Biomarker and Therapeutic Target for Gastric Cancer Identified by a Combination of Text Mining and RNA Sequencing	17
The Role of Myeloid-derived Suppressor Cells and Non-tumor Cells in theGlioma Microenvironment	17
Discovery of Genes Related to Cuproptosis and Mitophagy to Improve Myocardial Infarction Diagnosis and Treatment	16
Construction of a Vasculogenic Mimicry-related RiskScore Model to Assess Patient Prognosis and Immunotherapy Response in Head and Neck Squamous Cell Carcinoma	15
Screening and Functional Study of Biomarkers Related to Cell-in-cell Structure in Stomach Adenocarcinoma	15
Anesthesia and Cancer: Something More than Avoiding Stress Response	14
A Complete Sojourn of Gene Therapy along with its Targeting Approaches for the Treatment of the Major Depressive Disorder	14

From DNA Editing to RNA Regulation: The Breakthroughs of CRISPR and Mega-CRISPR	14
Identification of Potential Biomarkers in Autism: PRELID2, MYO1B, LRCH2, LIFR, and RERG May Serve as Regulators in Synaptic Membrane-Integrating Interneurons	12
Lentiviral Micro-dystrophin Gene Treatment into Late-stage mdx Mice for Duchenne Muscular Dystrophy Disease	12
Corrigendum to: Neuroprotection by Human Dental Pulp Mesenchymal Stem Cells: From Billions to Nano	12
Significance of Ribonucleoside-diphosphate Reductase Subunit M2 in Lung Adenocarcinoma	12
Role of Long Non-Coding RNA in Regulating ER Stress Response to the Progression of Diabetic Complications	12
Advancements in CAR-T Cell Therapy for Ovarian Cancer: Current Strategies and Future Directions	12
Revolutionizing Drug and Gene Delivery: Cutting-Edge Smart Polymers for Precision Release	12
Therapeutic Effects of Mesenchymal Stem Cells Carrying Echovirus inMouse Models of Breast Cancer	11
Effect of Bovine Lactoferrin Treatment on Iron Homeostasis and Gene Expression Changes in Multiple Organ Dysfunctions During Wound Healing Process in Rats	11
A Hypoxia-Regulated Retinal Pigment Epithelium-Specific Gene Therapy Vector Reduces Choroidal Neovascularization in a Mouse Model	11
Selecting Candidates for Genetic Therapy: A Patient-Centered Framework	11
Probing the Depths of Molecular Complexity: STAT3 as a Key Architect in Colorectal Cancer Pathogenesis	11
Genome Editing Technologies for Cancer Therapy	10
Mechanism of CAV and CAVIN Family Genes in Acute Lung Injury based on DeepGENE	10
Therapeutic Effects of Mesenchymal Stem Cells Expressing Erythropoietin on Cancer-Related Anemia in Mice Model	10
The Mitochondrial Deoxyribonucleic Acid Puzzle: Controversies, Challenges, and Critical Perspectives A Narrative Review	9
Padlock Assay in Transthyretin Amyloidosis: A Feasibility Study	9
Splicing DNA Damage Adaptations for the Management of Cancer Cells	9
CRISPR-Cas9: A Paradigm Shift in Gene Editing Addressing Antimicrobial Resistance	9
Gene Therapy for Chronic Traumatic Brain Injury: Challenges in Resolving Long-term Consequences of Brain Damage	9
Reduced Immunogenicity of Intraparenchymal Delivery of Adeno-Associated Virus Serotype 2 Vectors: Brief Overview	9
Revolution of Traditional Chinese Medicine in Anticancer Therapy, Applications and Future Perspective	9
Hemophilia Healing with AAV: Navigating the Frontier of Gene Therapy	8
Non-coding RNAs in Regulation of Protein Aggregation and Clearance Pathways: Current Perspectives Towards Alzheimer's Research and Therapy	8
Biogenesis and Function of circRNAs in Pulmonary Fibrosis	8
Synergistic Antiproliferative Effects of EGCG and Myricetin on Cervical Cancer Biomarkers in ME180 and SiHa Cell Lines	8
Segmentation of Thoracic Organs through Distributed Extraction of Visual Feature Patterns Utilizing Resio-Inception U-Net and Deep Cluster Recognition Techniques	8
HCST Expression Distinguishes Immune-hot and Immune-cold Subtypes in Pancreatic Ductal Adenocarcinoma	8
Gene Therapy for Rare Genetic Diseases	8
Prediction of SARS-CoV-2 Infection Phosphorylation Sites and Associations of these Modifications with Lung Cancer Development	8
Folic Acid-Conjugated Nanocarriers for Targeted Cancer Therapy: Recent Patents and Future Prospects	8
Novel Perspective of Regulating P53/Bcl2/Caspase-3 via In vitro Targeted AFP Gene Knocks Out in HepG2 Cells Using CRISPR/Cas9 Editing Tool	7
A Paradigm Shift in Hemophilia Care: The Promise of Gene Therapy	7
Immunoinformatic Based Designing of Immune Boosting and Nonallergenic Multi-epitope Subunit Vaccine Against the Enterovirus D68	7
Current Updates on the Role of MicroRNA in the Diagnosis and Treatment of Neurodegenerative Diseases	7
Role of Exosomal miRNAs and Epigenetic Modifications in Diabetic Nephropathy: Insights into Novel Diagnostic and Therapeutic Strategies	7
Computational Analysis Illustrates the Mechanism of Qingfei Paidu Decoction in Blocking the Transition of COVID-19 Patients from Mild to Severe Stage	7
Pan-Cancer Single-Cell Analysis Revealing the Heterogeneity of Cancer- Associated Fibroblasts in Skin Tumors	7
Transcription Factor EB Drives Thrombospondin-1 Expression to Dampen Focal-adhesion Signaling and Limit Post-infarction Cardiac Fibrosis	7
Untangling the Genetic Threads of Alzheimer's: Insights into Risk Factors and Biomarkers	7
A Comprehensive Review on Human Metapneumovirus	7
Single-cell and Bulk Transcriptomic Analyses Reveal a Stemness and Circadian Rhythm Disturbance-related Signature Predicting Clinical Outcome and Immunotherapy Response in Hepatocellular Carcinoma	7
Unraveling Etiological Indications and Therapeutic Implications of Familial Cerebral Cavernous Malformations in the Dawn of Gene Therapy for Monogenic Conditions	7
Dissecting the Mechanisms of Intestinal Immune Homeostasis by Analyzing T-Cell Immune Response in Crohn's Disease and Colorectal Cancer	7
Precision Medicine: Design of Immune Inert Exosomes for Targeted Gene Delivery	6
Hereditary Patterns and Genetic Associations in Obsessive-Compulsive Disorder (OCD): Neuropsychiatric Insights, Genetic Influences, and Treatment Perspectives	6
Targeting Extrachromosomal DNA (ecDNA) in Cancer: A New Era of CHK1 Inhibition and Personalized Treatments	6
CRISPR/Cas9 Technology for Modifying Immune Checkpoint in CAR-T Cell Therapy for Hematopoietic Malignancies	6
Transcriptomic Signatures in TP53 Positive and Negative Tumor Samplesin NSCLC	6

Knockdown of hsa_circ_0102231 Impedes the Progression of Liver Cancer through the miR-873–SOX4 Axis	6
Decoding Programmed Cell Death Genes: Innovations in Cancer Diagnosis and Treatment	6
Exploring the Epigenetic Mechanisms Underlying Chronic Diseases: A Comprehensive Review	6
Targeted Therapies and Computational Approaches in the Management of Crohn's Disease	6
AEG-1 as a Novel Therapeutic Target in Colon Cancer: A Study from Silencing AEG-1 in BALB/c Mice to Large Data Analysis	5
Immune Modulation Strategies in Gene Therapy: Overcoming Immune Barriers and Enhancing Efficacy	5
CRISPR/Cas System: A Powerful Strategy to Improve Monogenic Human Diseases as Therapeutic Delivery; Current Applications and Challenges	5
Single Injection AAV2-FGF18 Gene Therapy Reduces Cartilage Loss and Subchondral Bone Damage in a Mechanically Induced Model of Osteoarthritis	5
Review Deciphering the Anticancer Efficacy of Oroxylin A Targeting Dysregulated Oncogenes	5
The Role of Immunotherapy in Lung Cancer Treatment: Current Strategies, Future Directions, and Insights into Metastasis and Immune Microenvironment	5
Efficacy and Safety of Pembrolizumab Monotherapy or Combined Therapy in Patients with Metastatic Triple-negative Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials	5
Targeting of YKL-40 as a Protumor in Personalized Medicine: A New Dimension in Disease Understanding	5
The Role of RNA m6A Modification in Cancer Glycolytic Reprogramming	5
Machine Learning-Driven PCDI Classifier for Invasive PitNETs	4
Clinical Development of Cell Therapies to Halt Lysosomal Storage Diseases: Results and Lessons Learned	4
Unraveling Glioblastoma: TME Implication and Gene Therapy Advances	4
Tailored Therapies for Hereditary Diabetes: Unraveling the Genetic Underpinnings of MODY and Neonatal Diabetes	4
Acknowledgements to Reviewers	4
Gene Therapy for Hemophilia: Innovations, Milestones, and Future Prospects	4
CRISPR-Cas9: Transforming Functional Genomics, Precision Medicine, and Drug Development – Opportunities, Challenges, and Future Directions	4
Mammalian Stable Cell Platforms for Recombinant Adeno-associated Virus (rAAV) Production: Development Strategies and their Impact on Viral Productivity	4
Target and Gene-Based Therapeutic Strategies against Pancreatic Cancer: Current and Future Prospects	4
Recent Advances in Predicting Protein-lncRNA Interactions Using Machine Learning Methods	4
Reversal of Neuropsychiatric Comorbidities in an Animal Model of Temporal Lobe Epilepsy Following Systemic Administration of Dental Pulp Stem Cells and Bone Marrow Mesenchymal Stem Cells	4
Glioblastoma Organoid Technology: Approach to Target the Complex Tumor Microenvironment with Promising Drug Responsiveness	4
Gene Therapy for Skin Aging	4
Current Landscape and Emerging Opportunities of Gene Therapy with Non-viral Episomal Vectors	4
Neurotrophins as Potential Gene Therapy Targets for Huntington's Disease	4
Gene Therapy as a Novel Strategy for Alzheimer’s Disease: Efficacy and Long-Term Implications	4
FIGNL1 Promotes Hepatocellular Carcinoma Formation via Remodeling ECM-receptor Interaction Pathway Mediated by HMMR	4
Exploring Genetic and Receptor-Based Dopaminergic Strategies for Antidepressant Drug Development	4
miRNA-1260b Promotes Breast Cancer Cell Migration and Invasion by Downregulating CCDC134	3
Preface-2026	3
Implications of EBV-Encoded and EBV-Related miRNAs in Tumors	3
Targeting Undruggable Proteins: The siRNA Revolution Beyond Small Molecules - Advances, Challenges, and Future Prospects in Therapeutic Innovation	3
Meet the Editorial Board Member	3
Catechin Protects against Lipopolysaccharide-induced Depressive-like Behaviour in Mice by Regulating Neuronal and Inflammatory Genes	3
Development of Lentiviral Packaging Cells and Scale Up of Production to Meet the Growing Demand in Cell and Gene Therapy	3
siRNA Knocking Down in HepG2 Cells Identifies PFKFB4 and HNF4α as Key Genes Important for Cancer Cell Survival	3
miRNA-Targeted Vaccines: A Promising Approach for Viral Attenuation and Immunogenicity Enhancement	3
5-Alpha Reductase Deficiency - An Uncommon Disorder of Sexual Development: A Case Study of Four Turkish Patients within a Family	2
Duchenne Muscular Dystrophy Gene Therapy	2
Meet the Editorial Board Member	2
Inferring Cell-type-specific Genes of Lung Cancer Based on Deep Learning	2
Expression of miR-92a in Green Tea EGCG Preconditioned Adiposederived Stem Cells Ameliorates Inflammatory Response and Increases Cartilage Regeneration in RA Rats through KLF4/IL-17/MMP-2 Axis Modulat	2
Cancer Treatment Evolution from Traditional Methods to Stem Cells and Gene Therapy	2
Poly(rC) Binding Protein 1 Represses the Translation of STAT3 through 5' UTR	2
Challenges in the Stability, Safety, and Efficacy of Antisense Oligonucleotide Therapeutics	2
Polysaccharide-Based Delivery Systems for CRISPR/Cas Gene Therapy: Overcoming Challenges and Advancing Pharmaceutical Solutions	2
Transforming RNA-Based Gene Therapy with Innovative Nanocarriers for siRNA and miRNA Delivery	2
Advancing Antibacterial Strategies: CRISPR-Phage-Mediated Gene Therapy Targeting Bacterial Resistance Genes	2
Proteomic Analyses Reveal Functional Pathways and Potential Targets in Pediatric Hydrocephalus	2
Advancements in CRISPR-Based Therapies for Genetic Modulation in Neurodegenerative Disorders	2
Development of Cell and Gene Therapies for Clinical Use in the US and EU: Summary of Regulatory Guidelines	2
ZNF695, A Potential Prognostic Biomarker, Correlates with Im mune Infiltrates in Cervical Squamous Cell Carcinoma and Endoce rvical Adenocarcinoma: Bioinformatic Analysis and Experimental Verification	2
Macrophage-related Genes were Discovered by Applying Highdimensional Weighted Gene Co-expression Network Analysis as Biomarkers for Esophageal Squamous Cell Carcinoma	2
Characteristics of Oxidative Phosphorylation-Related Subtypes and Construction of a Prognostic Signature in Ovarian Cancer	2
Plasmalogens Activate AKT/mTOR Signaling to Attenuate Reactive Oxygen Species Production in Spinal Cord Injury	2
Gene Therapy Cargoes Based on Viral Vector Delivery	2