OOIR: Observatory of International Research

Papers

(The median citation count of Current Gene Therapy is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
miRNA-146a Improves Immunomodulatory Effects of MSC-derived Exosomes in Rheumatoid Arthritis	86
Gene Therapy in the Anterior Eye Segment	49
The Emerging Role of Stem Cells in Regenerative Dentistry	44
Recent Progress of Machine Learning in Gene Therapy	23
Strategic Developments & Future Perspective on Gene Therapy for Breast Cancer: Role of mTOR and Brk/ PTK6 as Molecular Targets	23
Inferring Cell-type-specific Genes of Lung Cancer Based on Deep Learning	22
Recent Advances in Predicting Protein-lncRNA Interactions Using Machine Learning Methods	18
Effect of Rat Bone Marrow Derived-Mesenchymal Stem Cells on Granulocyte Differentiation of Mononuclear Cells as Preclinical Agent in Cellbased Therapy	18
Gene Therapy Approaches in an Autoimmune Demyelinating Disease: Multiple Sclerosis	18
Single-cell RNA Sequencing Analysis Identifies Key Genes in Brain Metastasis from Lung Adenocarcinoma	17
Gene Therapy Based on Lipid Nanoparticles as Non-viral Vectors for Glioma Treatment	16
Molecular Genetics of Early- and Late-Onset Alzheimer’s Disease	15
Cancer Treatment Evolution from Traditional Methods to Stem Cells and Gene Therapy	14
Computational Analysis Illustrates the Mechanism of Qingfei Paidu Decoction in Blocking the Transition of COVID-19 Patients from Mild to Severe Stage	14
Stem Cell Transplantation Improves Ovarian Function through Paracrine Mechanisms	14
Current Landscape and Emerging Opportunities of Gene Therapy with Non-viral Episomal Vectors	14
A Five-gene Signature for Predicting the Prognosis of Colorectal Cancer	14
miR-1-3p/CELSR3 Participates in Regulating Malignant Phenotypes of Lung Adenocarcinoma Cells	12
Hutchinson-Gilford Progeria Syndrome: An Overview of the Molecular Mechanism, Pathophysiology and Therapeutic Approach	12
Therapeutic Potential of POU3F3, a Novel Long Non-coding RNA, Alleviates the Pathogenesis of Osteoarthritis by Regulating the miR-29a- 3p/FOXO3 Axis	12
Mesenchymal Stromal Cells (MSCs): A Promising Tool for Cell-Based Angiogenic Therapy	12
Mesenchymal Stem Cells Promote Caspase Expression in Molt-4 Leukemia Cells Via GSK-3α/Β and ERK1/2 Signaling Pathways as a Therapeutic Strategy	11
CAR-NK Cells for Cancer Therapy: Molecular Redesign of the Innate Antineoplastic Response	11
miR-375 Inhibits the Proliferation, Migration and Invasion of Esophageal Squamous Cell Carcinoma by Targeting XPR1	11
Identification of Chronic Hypersensitivity Pneumonitis Biomarkers with Machine Learning and Differential Co-expression Analysis	11

Predicting LncRNA-Disease Association Based on Generative Adversarial Network	11
Exploring the Role of Gene Therapy for Neurological Disorders	11
Gene Therapy, A Potential Therapeutic Tool for Neurological and Neuropsychiatric Disorders: Applications, Challenges and Future Perspective	10
Feasibility of Mesenchymal Stem Cell Therapy for COVID-19: A Mini Review	10
CRISPR Systems Suitable for Single AAV Vector Delivery	10
Genetically-modified Stem Cell in Regenerative Medicine and Cancer Therapy; A New Era	10
Potential Non-coding RNAs from Microorganisms and their Therapeutic Use in the Treatment of Different Human Cancers	9
CRISPR/Cas9 Technology as a Modern Genetic Manipulation Tool for Recapitulating of Neurodegenerative Disorders in Large Animal Models	9
MicroRNAs: A Critical Regulator and a Promising Therapeutic and Diagnostic Molecule for Diabetic Cardiomyopathy	9
Therapeutic Approaches for the Management of Autoimmune Disorders via Gene Therapy: Prospects, Challenges and Opportunities	8
The Effectiveness of Nanoparticles on Gene Therapy for Glioblastoma Cells Apoptosis: A Systematic Review	8
Current Designs of Polymeric Platforms Towards the Delivery of Nucleic Acids Inside the Cells with Focus on Polyethylenimine	8
Gene Therapy Cargoes Based on Viral Vector Delivery	8
TGF-β1-based CRISPR/Cas9 Gene Therapy Attenuates Radiation-induced Lung Injury	8
Delivery Systems for RNA Interference Therapy: Current Technologies and Limitations	7
miRNA-1260b Promotes Breast Cancer Cell Migration and Invasion by Downregulating CCDC134	7
Poly(rC) Binding Protein 1 Represses the Translation of STAT3 through 5' UTR	7
CRISPR/Cas9 Genome Editing Tool: A Promising Tool for Therapeutic Applications on Respiratory Diseases	7
Popularizing Recombinant Baculovirus-derived OneBac System for Laboratory Production of all Recombinant Adeno-associated Virus Vector Serotypes	7
AAV9-coGLB1 Improves Lysosomal Storage and Rescues Central Nervous System Inflammation in a Mutant Mouse Model of GM1 Gangliosidosis	7
Overexpressing Runx2 of BMSCs Improves the Repairment of knee Cartilage Defects	6
Teratogenic Toxicity Evaluation of Bladder Cancer-Specific Oncolytic Adenovirus on Mice	6
Exosomal miRNAs as Next-generation Therapy Vehicles in Breast Cancer	6
The Dramatic Role of IFN Family in Aberrant Inflammatory Osteolysis	6
Effective Downregulation of BCR-ABL Tumorigenicity by RNA Targeted CRISPR-Cas13a	6
Human Retinal Pigment Epithelial Cells Overexpressing the Neuroprotective Proteins PEDF and GM-CSF to Treat Degeneration of the Neural Retina	6
Epigenetic Modifications in Acute Lymphoblastic Leukemia: From Cellular Mechanisms to Therapeutics	6
Reversal of Neuropsychiatric Comorbidities in an Animal Model of Temporal Lobe Epilepsy Following Systemic Administration of Dental Pulp Stem Cells and Bone Marrow Mesenchymal Stem Cells	6
Role of Long Non-Coding RNA in Regulating ER Stress Response to the Progression of Diabetic Complications	5
Recombinant Human p53 Adenovirus Injection (rAd-p53) Combined with Chemotherapy for 4 Cases of High-grade Serous Ovarian Cancer	5
Recombinant Adeno-associated Virus 9-mediated Expression of Kallistatin Suppresses Lung Tumor Growth in Mice	5
Viral Vector Delivery of DREADDs for CNS Therapy	5
Clinical Development of Cell Therapies to Halt Lysosomal Storage Diseases: Results and Lessons Learned	5
The Role of RNA m6A Modification in Cancer Glycolytic Reprogramming	5
CRISPR-Based Therapies: Revolutionizing Drug Development and Precision Medicine	4
Identification of Gene Signature Associated with Type 2 Diabetes Mellitus by Integrating Mutation and Expression Data	4
In Situ Gene Therapy	4
Exosomal MiR-29a in Cardiomyocytes Induced by Angiotensin II Regulates Cardiac Microvascular Endothelial Cell Proliferation, Migration and Angiogenesis by Targeting VEGFA	4
New Hope for Intervertebral Disc Degeneration: Bone Marrow Mesenchymal Stem Cells and Exosomes Derived from Bone Marrow Mesenchymal Stem Cell Transplantation	4
Newly Designed Decellularized Scaffolds for Scaffold-based Gene Therapy from Elastic Cartilages via Supercritical Carbon Dioxide Fluid and Alkaline/ Protease Treatments	4
Gene Therapy for Alzheimer and Parkinson Diseases	4
Identification of HnRNP Family as Prognostic Biomarkers in Five Major Types of Gastrointestinal Cancer	4
Identification and Analysis of RNA Editing Events in Ovarian Serous Cystadenoma Using RNA-seq Data	4
The Effects of Human Umbilical Cord Mesenchymal Stem Cell Transplantation on Female Fertility Restoration in Mice	4
Targeted Delivery for Neurodegenerative Disorders Using Gene Therapy Vectors: Gene Next Therapeutic Goals	4
Prediction of SARS-CoV-2 Infection Phosphorylation Sites and Associations of these Modifications with Lung Cancer Development	4
Treatment of GM2 Gangliosidosis in Adult Sandhoff Mice Using an Intravenous Self-Complementary Hexosaminidase Vector	4
Gene Therapy Strategies for Glaucomatous Neurodegeneration	4
Gene Therapy for Critical Limb Ischemia: Per Aspera ad Astra	3
In-silico Molecular Interaction of Short Synthetic Lipopeptide/Importin-alpha and In-vitro Evaluation of Transgene Expression Mediated by Liposome- Based Gene Carrier	3

Duchenne Muscular Dystrophy Gene Therapy	3
Applications of Scaffolds in Tissue Engineering: Current Utilization and Future Prospective	3
Genetic Engineering of AAV Capsid Gene for Gene Therapy Application	3
High-Throughput Sequencing Reveals N6-Methyladenosine-modified LncRNAs as Potential Biomarkers in Mice with Liver Fibrosis	3
Mesenchymal Stem Cells: A New Generation of Therapeutic Agents as Vehicles in Gene Therapy	3
SFXN3 is Associated with Poor Clinical Outcomes and Sensitivity to the Hypomethylating Therapy in Non-M3 Acute Myeloid Leukemia Patients	3
Gene Therapy of Mucopolysaccharidosis Type I Mice: Repeated Administrations and Safety Assessment of pIDUA/Nanoemulsion Complexes	3
Association of MicroRNA-652 Expression with Radiation Response of Colorectal Cancer: A Study from Rectal Cancer Patients in a Swedish Trial of Preoperative Radiotherapy	3
Evaluation of the Nucleopolyhedrovirus of Anticarsia gemmatalis as a Vector for Gene Therapy in Mammals	3
Prospects of Non-Coding Elements in Genomic DNA Based Gene Therapy	3
Dysregulation of Transfer RNA-derived Small RNAs that Regulate Cell Activity and its Related Signaling Pathways in Human Cancers	3
Hemophilia Healing with AAV: Navigating the Frontier of Gene Therapy	3
A Hypoxia-Regulated Retinal Pigment Epithelium-Specific Gene Therapy Vector Reduces Choroidal Neovascularization in a Mouse Model	3
Vector-Mediated Delivery of Transgenes and RNA Interference-Based Gene Silencing Sequences to Astrocytes for Disease Management: Advances and Prospectives	3
Therapeutic Effects of Mesenchymal Stem Cells Expressing Erythropoietin on Cancer-Related Anemia in Mice Model	3
Cytoplasmic Trafficking of Nanoparticles Delivers Plasmid DNA for Macrophage Gene-editing	3
Nanoparticle-Based Gene Therapy Intervention for Stroke Treatment: A Systematic Review	3
TRPM8 as a Potential Biomarker and Therapeutic Target for Gastric Cancer Identified by a Combination of Text Mining and RNA Sequencing	3
A Quest to the Therapeutic Arsenal: Novel Strategies to Combat Multidrug- resistant Bacteria	3
Amyotrophic Lateral Sclerosis Risk Genes and Suppressor	3