OOIR: Observatory of International Research

Papers

(The TQCC of Epigenetics is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Vitamin C enhances co-localization of novel TET1 nuclear bodies with both Cajal and PML bodies in colorectal cancer cells	80
Coordinated alternation of DNA methylation and alternative splicing of PBRM1 affect bovine sperm structure and motility	70
Maternal plasma fatty acid patterns in mid-pregnancy and offspring epigenetic gestational age at birth	53
Genome-wide CpG density and DNA methylation analysis method (MeDIP, RRBS, and WGBS) comparisons	40
Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet	29
DNA methylation markers for risk of metastasis in a cohort of men with localized prostate cancer	26
Gestational diabetes mellitus placentas exhibit epimutations at placental development genes	25
N6-methyladenosine methylation analysis of long noncoding RNAs and mRNAs in 5-FU-resistant colon cancer cells	22
Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene	21
Identification and functional characterisation of DNA methylation differences between East- and West-originating Finns	21
Whole human genome 5’-mC methylation analysis using long read nanopore sequencing	20
Prenatal medication exposure and epigenetic outcomes: a systematic literature review and recommendations for prenatal pharmacoepigenetic studies	20
Tumour suppressor TET2 safeguards enhancers from aberrant DNA methylation and epigenetic reprogramming in ERα-positive breast cancer cells	19
Clinical significance of peripheral blood DDR1 and CtBP gene methylation detection in patients with acute pancreatitis	18
A key regulatory loop AK4P1/miR-375/SP1 in pancreatic adenocarcinoma	18
Epigenetic landscape of 5-hydroxymethylcytosine and associations with gene expression in placenta	17
Disentangling tumorigenesis-associated DNA methylation changes in colorectal tissues from those associated with ageing	17
DNA methylome-based validation of induced sputum as an effective protocol to study lung immunity: construction of a classifier of pulmonary cell types	17
Role of N6-methyladenosine-related lncRnas in pseudoexfoliation glaucoma	16
Dynamics of methylated cell-free DNA in the urine of non-small cell lung cancer patients	16
Chimpanzee Extraversion scores vary with epigenetic modification of dopamine receptor gene D2 (DRD2) and early rearing conditions	15
Letter to the editor: critical evaluation of the reliability of DNA methylation probes on the illumina MethylationEPIC v1.0 BeadChip microarrays	15
Using Cg05575921 methylation to predict lung cancer risk: a potentially bias-free precision epigenetics approach	15
Placental DNA methylation in pregnancies complicated by maternal diabetes and/or obesity: State of the art and research gaps	15
Epigenome-wide association studies of occupational exposure to benzene and formaldehyde	14

Epigenetic control of the imprinted growth regulator Cdkn1c in cadmium-induced placental dysfunction	14
NSUN2-mediated RNA m⁵C modification modulates uveal melanoma cell proliferation and migration	14
Dominant effects of the histone mutant H3-L61R on Spt16-gene interactions in budding yeast	14
Multi-tissue DNA methylation microarray signature is predictive of gene function	14
Impact of testicular cancer on sperm small non-coding RNA signature: a pilot study	14
In vivo DNA methylation editing in zebrafish	13
Sex-specific DNA methylation and transcription of zbtb38 and effects of gene–environment interactions on its natural antisense transcript in zebrafish	13
In silico identification and in vitro expression analysis of breast cancer-related m⁶A-SNPs	13
Epigenome wide association study in peripheral blood of pregnant women identifies potential metabolic pathways related to gestational diabetes	13
Methylation profiles of global LINE-1 DNA and the GSTP1 promoter region in children exposed to lead (Pb)	13
Pharmacoepigenetics of hypertension: genome-wide methylation analysis of responsiveness to four classes of antihypertensive drugs using a double-blind crossover study design	12
Digital methylation assessments of alcohol and cigarette consumption account for common variance in accelerated epigenetic ageing	12
Epigenetic age acceleration, neonatal morbidities, and neurobehavioral profiles in infants born very preterm	11
TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy	11
Animal and plant protein intake during infancy and childhood DNA methylation: a meta-analysis in the NutriPROGRAM consortium	11
Fusaric acid induces hepatic global m6A RNA methylation and differential expression of m6A regulatory genes in vivo - a pilot study	11
Epigenome-wide association study of long-term psychosocial stress in older adults	11
GGNBP2 regulates histone ubiquitination and methylation in spermatogenesis	11
DNA methylome and transcriptome profiling reveal key electrophysiology and immune dysregulation in hypertrophic cardiomyopathy	11
GPX8 deficiency–induced oxidative stress reprogrammed m6A epitranscriptome of oral cancer cells	11
Co-occurrence of injection drug use and hepatitis C increases epigenetic age acceleration that contributes to all-cause mortality among people living with HIV	11
Genetic architecture of epigenetic cortical clock age in brain tissue from older individuals: alterations in CD46 and other loci	11
Placental malaria induces a unique methylation profile associated with fetal growth restriction	10
IL-18 serves as a main effector of CAF-derived METTL3 against immunosuppression of NSCLC via driving NF-κB pathway	10
Correction	10
Leukocyte DNA methylation in Alzheimer´s disease associated genes: replication of findings from neuronal cells	10
Human non-CpG methylation patterns display both tissue-specific and inter-individual differences suggestive of underlying function	10
Weight loss reduces circulating micro-RNA related to obesity and breast cancer in postmenopausal women	10
Histone deacetylase 3 regulates microglial function through histone deacetylation	10
IL21R hypomethylation as a biomarker for distinguishing benign and malignant breast tumours	10
Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice	10
Epigenetic aging of semen is associated with inflammation	10
Occupational characteristics and epigenetic aging among older adults in the United States	10
An epigenome-wide analysis of sex hormone levels and DNA methylation in male blood samples	10
m6A reader YTHDC2 mediates NCOA4 mRNA stability affecting ferritinophagy to alleviate secondary injury after intracerebral haemorrhage	10
Using methylation data to improve transcription factor binding prediction	10
Urinary metals and maternal circulating extracellular vesicle microRNA in the MADRES pregnancy cohort	10
Overlapping functions of RBBP4 and RBBP7 in regulating cell proliferation and histone H3.3 deposition during mouse preimplantation development	10
Detailed immune profiling in pediatric Crohn’s disease using methylation cytometry	9
Homocysteine affects macrophage polarization by altering m6A methylation of scavenger receptors CD209 and CD163L1	9
Epigenetic aging in cows is accelerated by milk production	9
The influence of intergenerational trauma on epigenetics and obesity in Indigenous populations - a scoping review	9
YY1/circCTNNB1/miR-186-5p/YY1 positive loop aggravates lung cancer progression through the Wnt pathway	9
Domain architecture and protein–protein interactions regulate KDM5A recruitment to the chromatin	9
Pruning and thresholding approach for methylation risk scores in multi-ancestry populations	9
MicroRNA-185-5p: a marker of brain-sparing in foetuses with late-onset growth restriction	9
Detection of DNA methylation from buccal swabs using nanopore sequencing to study stunting	9
Poly-epigenetic scores for cardiometabolic risk factors interact with demographic factors and health behaviors in older US Adults	9
A promising application of kidney-specific cell-free DNA methylation markers in real-time monitoring sepsis-induced acute kidney injury	8
Nitric oxide-related gene and microRNA expression in peripheral blood in pregnancy vary by self-reported race	8

A novel principal component based method for identifying differentially methylated regions in Illumina Infinium MethylationEPIC BeadChip data	8
ANRIL upregulates TGFBR1 to promote idiopathic pulmonary fibrosis in TGF-β1-treated lung fibroblasts via sequestering let-7d-5p	8
A comparison of epithelial cell content of oral samples estimated using cytology and DNA methylation	8
Arabidopsis thaliana: a powerful model organism to explore histone modifications and their upstream regulations	8
Association of DNA methylation signatures with premature ageing and cardiovascular death in patients with end-stage kidney disease: a pilot epigenome-wide association study	8
ZNF143 inhibits hepatocyte mitophagy and promotes non-alcoholic fatty liver disease by targeting increased lncRNA NEAT1 expression to activate ROCK2 pathway	8
Differential methylation pattern in pubertal girls associated with biochemical premature adrenarche	8
Updates to data versions and analytic methods influence the reproducibility of results from epigenome-wide association studies	8
Resistance and aerobic training increases genome-wide DNA methylation in women with polycystic ovary syndrome	8
ABCA1, TCF7, NFATC1, PRKCZ, and PDGFA DNA methylation as potential epigenetic-sensitive targets in acute coronary syndrome via network analysis	8
The Socioeconomic Gradient in Epigenetic Ageing Clocks: Evidence from the Multi-Ethnic Study of Atherosclerosis and the Health and Retirement Study	8
Methylome profile of medaka eggs and sperm	8
Proposal of a bioinformatics approach to predict molecular mechanisms involved in inflammatory response: case of ATRA and 1,25(OH) ₂ D in adipocytes	8
Evaluating the utility of ZNF331 promoter methylation as a prognostic and predictive marker in stage III colon cancer: results from CALGB 89803 (Alliance)	8
CircRNF111 Contributes to Adipocyte Differentiation by Elevating PPARγ Expression via miR-27a-3p	8
Deciphering the interplay between SETD2 mediated H3K36me3 and RNA N6-methyladenosine in clear cell renal cell carcinoma (ccRCC)	8
Long-range chromosomal interactions increase and mark repressed gene expression during adipogenesis	7
Birth weight and maternal energy status during pregnancy as predictors of epigenetic age acceleration in young adults from metropolitan Cebu, Philippines	7
Crosstalk between m6A mRNAs and m6A circRNAs and the time-specific biogenesis of m6A circRNAs after OGD/R in primary neurons	7
An investigation into DNA methylation patterns associated with risk preference in older individuals	7
Transgenerational epigenetic self-memory of Dio3 dosage is associated with Meg3 methylation and altered growth trajectories and neonatal h	7
Roles of adenine methylation and genetic mutations in adaptation to different temperatures in Serratia marcescens	7
Histone demethylase KDM4B contributes to advanced clear cell renal carcinoma and association with copy number variations and cell cycle progression	7
Sirtuin1 in vascular endothelial function, an overview	7
Multiomics analysis of adaptation to repeated DNA damage in prostate cancer cells	7
Targeted epigenetic silencing of UCHL1 expression suppresses collagen-1 production in human lung epithelial cells	7
Oleic acid-related anti-inflammatory effects in force-stressed PdL fibroblasts are mediated by H3 lysine acetylation associated with altered IL10 expression	7
Evaluation of methylated DCR1 as a biomarker for response to adjuvant irinotecan-based therapy in stage III colon cancer: cancer and leukaemia Group B 89803 (Alliance)	7
CircMYH9 promotes the mRNA stability of SPAG6 by recruiting EIF4A3 to facilitate the progression of breast cancer	7
m ⁶ A RNA methylation regulators predict prognosis and indicate characteristics of tumour microenvironment infiltration in acute myeloid leukaemia	7
Contribution of miR-124 rs531564 polymorphism to the occurrence of congenital Zika syndrome	7
Epigenetic ageing of the prefrontal cortex and cerebellum in humans and chimpanzees	7
Novel DNA methylation loci and genes showing pleiotropic association with Alzheimer’s dementia: a network Mendelian randomization analysis	7
Hypermethylation of the oxytocin receptor gene (OXTR) in obsessive-compulsive disorder: further evidence for a biomarker of disease and treatment response	7
Aberrant regulation of CXCR4 in cancer via deviant microRNA-targeted interactions	7
Prenatal maternal stress is associated with site-specific and age acceleration changes in maternal and newborn DNA methylation	7
Evaluating DNA recovery efficiency following bisulphite modification from plasma samples submitted for cell-free DNA methylation analysis	7
Maternal blood metal concentrations and whole blood DNA methylation during pregnancy in the Early Autism Risk Longitudinal Investigation (EARLI)	7
Suppressing circIDE/miR-19b-3p/RBMS1 axis exhibits promoting-tumour activity through upregulating GPX4 to diminish ferroptosis in hepatocellular carcinoma	7
One-carbon metabolism nutrients impact the interplay between DNA methylation and gene expression in liver, enhancing protein synthesis in Atlantic salmon	7
Prenatal Socioeconomic Disadvantage and Epigenetic Alterations at Birth Among Children Born to White British and Pakistani Mothers in the Born in Bradford Study	7
An epigenetic human cytomegalovirus infection score predicts viremia risk in seropositive lung transplant recipients	7