OOIR: Observatory of International Research

Papers

(The TQCC of Epigenetics is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Leukocyte DNA methylation in Alzheimer´s disease associated genes: replication of findings from neuronal cells	84
Disentangling tumorigenesis-associated DNA methylation changes in colorectal tissues from those associated with ageing	73
Epigenetic landscape of 5-hydroxymethylcytosine and associations with gene expression in placenta	60
Digital methylation assessments of alcohol and cigarette consumption account for common variance in accelerated epigenetic ageing	41
Placental DNA methylation in pregnancies complicated by maternal diabetes and/or obesity: State of the art and research gaps	31
Identification and functional characterisation of DNA methylation differences between East- and West-originating Finns	29
Role of N6-methyladenosine-related lncRnas in pseudoexfoliation glaucoma	26
Using methylation data to improve transcription factor binding prediction	23
GGNBP2 regulates histone ubiquitination and methylation in spermatogenesis	23
Co-occurrence of injection drug use and hepatitis C increases epigenetic age acceleration that contributes to all-cause mortality among people living with HIV	22
The influence of intergenerational trauma on epigenetics and obesity in Indigenous populations - a scoping review	21
N6-methyladenosine methylation analysis of long noncoding RNAs and mRNAs in 5-FU-resistant colon cancer cells	21
Detailed immune profiling in pediatric Crohn’s disease using methylation cytometry	20
Generational stability of epigenetic transgenerational inheritance facilitates adaptation and evolution	20
Proposal of a bioinformatics approach to predict molecular mechanisms involved in inflammatory response: case of ATRA and 1,25(OH) ₂ D in adipocytes	19
Differential methylation pattern in pubertal girls associated with biochemical premature adrenarche	19
Multiomics analysis of adaptation to repeated DNA damage in prostate cancer cells	18
Roles of adenine methylation and genetic mutations in adaptation to different temperatures in Serratia marcescens	18
Placental malaria induces a unique methylation profile associated with fetal growth restriction	17
Identification cloning and functional analysis of novel natural antisense lncRNA CFL1-AS1 in cattle	17
CircRNF111 Contributes to Adipocyte Differentiation by Elevating PPARγ Expression via miR-27a-3p	17
The Socioeconomic Gradient in Epigenetic Ageing Clocks: Evidence from the Multi-Ethnic Study of Atherosclerosis and the Health and Retirement Study	17
Identification and characterization of extrachromosomal circular DNA in patients with high myopia and cataract	16
DNA methylome in visceral adipose tissue can discriminate patients with and without colorectal cancer	16
The UHRF1 protein is a key regulator of retrotransposable elements and innate immune response to viral RNA in human cells	16

Accelerated epigenetic age at birth and child emotional and behavioural development in early childhood: a meta-analysis of four prospective cohort studies in ECHO	15
MYCN and HIF-1 directly regulate TET1 expression to control 5-hmC gains and enhance neuroblastoma cell migration in hypoxia	15
Repurposing epigenetic inhibitors to target the Clostridioides difficile-specific DNA adenine methyltransferase and sporulation regulator CamA	15
Acetaldehyde-driven mRNA methylation and expression changes in ethanol-metabolizing enzyme genes	15
Genomic context determines the effect of DNA methylation on gene expression in the gut epithelium of Atlantic salmon ( Salmo salar )	14
Polymethylation scores for prenatal maternal smoke exposure persist until age 15 and are detected in saliva in the Fragile Families and Child Wellbeing cohort	13
Regulatory networks of circRNA- centred ceRNAs in sepsis-induced acute kidney injury	13
Placental and immune cell DNA methylation reference panel for bulk tissue cell composition estimation in epidemiological studies	13
Validation of the new EPIC DNA methylation microarray (900K EPIC v2) for high-throughput profiling of the human DNA methylome	13
Direction-aware functional class scoring enrichment analysis of infinium DNA methylation data	13
Pan-precancer and cancer DNA methylation profiles revealed significant tissue specificity of interrupted biological processes in tumorigenesis	13
ELOVL2-AS1 suppresses tamoxifen resistance by sponging miR-1233-3p in breast cancer	13
Selenium-associated differentially expressed microRNAs and their targeted mRNAs across the placental genome in two U.S. birth cohorts	13
Epigenome-wide association study of loneliness in a sample of U.S. middle-aged twins	13
Interrelationship between miRNA and splicing factors in pancreatic ductal adenocarcinoma	12
Integration of miRNA expression analysis of purified leukocytes and whole blood reveals blood-borne candidate biomarkers for lung cancer	12
The role of DNA methylation on gene expression in the vertebrae of ancestrally benzo[a]pyrene exposed F1 and F3 male medaka	12
Comprehensive analysis of m ⁶ A methylomes in idiopathic pulmonary arterial hypertension	12
Long non-coding RNA Gm10561 promotes myogenesis by sponging miR-432	12
Direct bisulphite conversion of cervical samples for DNA methylation analysis	12
Blood DNA methylation signatures are associated with social determinants of health among survivors of childhood cancer	11
Timing of dietary effects on the epigenome and their potential protective effects against toxins	11
The one-carbon metabolism as an underlying pathway for placental DNA methylation – a systematic review	11
CircRIMKLB promotes myoblast proliferation and inhibits differentiation by sponging miR-29c to release KCNJ12	11
Chemotherapy-induced acceleration of DNA methylation-based biological age in breast cancer	11
Large-scale integration of DNA methylation and gene expression array platforms identifies both cis and trans relationships	11
Cumulative stress, PTSD, and emotion dysregulation during pregnancy and epigenetic age acceleration in Hispanic mothers and their newborn infants	11
Associations between infant sex and DNA methylation across umbilical cord blood, artery, and placenta samples	11
Upregulation of KHDC1L promotes the proliferation and inhibits apoptosis in head and neck squamous cell carcinoma	11
Study on chromatin regulation patterns of expression vectors in the PhiC31 integration site	10
DNMT1 expression partially dictates 5-Azacytidine sensitivity and correlates with RAS/MEK/ERK activity in gastric cancer cells	10
Alterations in DNA methylation associate with fatty liver and metabolic abnormalities in a multi-ethnic cohort of pre-teenage children	10
Gaps in current methods to detect polymorphic CpGs from Illumina Infinium human methylation microarrays and exploring their potential impact in multi-EWAS analyses	10
mir152hypomethylation as a mechanism for non-syndromic cleft lip and palate	10
Hypomethylation at H19DMR in penile squamous cell carcinoma is not related to HPV infection	10
DNA methylation changes in glial cells of the normal-appearing white matter in Multiple Sclerosis patients	10
Biological stability of DNA methylation measurements over varying intervals of time and in the presence of acute stress	10
ΔNp63α-mediated epigenetic regulation in keratinocyte senescence	10
Upregulation of GPR133 expression impaired the phagocytosis of macrophages in recurrent spontaneous miscarriage	10
Heavy alcohol consumption but not smoking predicts mortality in patients with acute coronary syndrome	10
DNA-based cell typing in menstrual effluent identifies cell type variation by sample collection method: toward noninvasive biomarker development for women’s health	10
DNA methylation at birth and fine motor ability in childhood: an epigenome-wide association study with replication	10
Cut&tag: a powerful epigenetic tool for chromatin profiling	10
Detecting aberrant DNA methylation in Illumina DNA methylation arrays: a toolbox and recommendations for its use	10
RNA modification m ⁶ Am: the role in cardiac biology	9
Dynamics of methylated cell-free DNA in the urine of non-small cell lung cancer patients	9
DNA methylation profiles in bovine sperm are associated with daughter fertility	9
Dietary and supplemental intake of vitamins C and E is associated with altered DNA methylation in an epigenome-wide association study meta-analysis	9
Analysis of global DNA methylation and epigenetic modifiers (DNMTs and HDACs) in human foetal endothelium exposed to gestational and type 2 diabetes	9
Assessment of aberrant DNA methylation two years after paediatric critical illness: a pre-planned secondary analysis of the international PEPaNIC trial	9

Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene	9
Epigenome wide association study in peripheral blood of pregnant women identifies potential metabolic pathways related to gestational diabetes	8
Novel DNA methylation loci and genes showing pleiotropic association with Alzheimer’s dementia: a network Mendelian randomization analysis	8
Precise epigenomic editing with a SunTag-based modular epigenetic toolkit	8
Oleic acid-related anti-inflammatory effects in force-stressed PdL fibroblasts are mediated by H3 lysine acetylation associated with altered IL10 expression	8
Stress-induced epigenetic effects driven by maternal lactation in dairy cattle: a comethylation network approach	8
Methylome profile of medaka eggs and sperm	8
Domain architecture and protein–protein interactions regulate KDM5A recruitment to the chromatin	8
m6A reader YTHDC2 mediates NCOA4 mRNA stability affecting ferritinophagy to alleviate secondary injury after intracerebral haemorrhage	8
NSUN2-mediated RNA m⁵C modification modulates uveal melanoma cell proliferation and migration	8
Higher sperm H3K4me3 levels are associated with idiopathic recurrent pregnancy loss	8
Time-course full profiling of circulating miRNAs in neurologically deceased organ donors: a proof of concept study to understand the onset of the cytokine storm	8
Memory B-cell like chronic lymphocytic leukaemia is associated with specific methylation profile of WNT5A promoter and undetectable expression of WNT5A gene	8
Prenatal Socioeconomic Disadvantage and Epigenetic Alterations at Birth Among Children Born to White British and Pakistani Mothers in the Born in Bradford Study	8
Detection of DNA methylation from buccal swabs using nanopore sequencing to study stunting	8
Epigenetic age acceleration, neonatal morbidities, and neurobehavioral profiles in infants born very preterm	8
A novel principal component based method for identifying differentially methylated regions in Illumina Infinium MethylationEPIC BeadChip data	8
Comparison of EM-seq and PBAT methylome library methods for low-input DNA	8
History of exposure to copper influences transgenerational gene expression responses in Daphnia magna	8
Uncertainty quantification of reference-based cellular deconvolution algorithms	8
Sirtuin1 in vascular endothelial function, an overview	8
Genome-wide CpG density and DNA methylation analysis method (MeDIP, RRBS, and WGBS) comparisons	8