OOIR: Observatory of International Research

Papers

(The median citation count of Clinical Toxicology is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
2019 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 37th Annual Report	261
2020 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 38th Annual Report	215
2021 Annual Report of the National Poison Data System ^© (NPDS) from America’s Poison Centers: 39th Annual Report	109
North American Congress of Clinical Toxicology (NACCT) 2022	92
North American Congress of Clinical Toxicology (NACCT) 2023	84
43rd International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT), 23–26 May 2023, Palma de Mallorca, Spain	60
2022 Annual Report of the National Poison Data System ^® (NPDS) from America’s Poison Centers ^® : 40th Annual Report	39
Opioid overdoses involving xylazine in emergency department patients: a multicenter study	36
Reddit discussions about buprenorphine associated precipitated withdrawal in the era of fentanyl	34
42nd International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) 24-27 May 2022, Tallinn, Estonia	34
Pediatric cannabis intoxication trends in the pre and post-legalization era	32
Xylazine poisoning: a systematic review	32
The serotonin toxidrome: shortfalls of current diagnostic criteria for related syndromes	30
Nine prohibited stimulants found in sports and weight loss supplements: deterenol, phenpromethamine (Vonedrine), oxilofrine, octodrine, beta-methylphenylethylamine (BMPEA), 1,3-dimethylamylamine (1,3-	28
Rising incidence and high mortality in intentional sodium nitrite exposures reported to US poison centers	27
Acute diquat poisoning resulting in toxic encephalopathy: a report of three cases	26
Ivermectin: a mini-review	25
Sodium azide poisoning: a narrative review	25
Poisoning during the COVID-19 outbreak and lockdown: retrospective analysis of exposures reported to French poison control centres	25
Fatal serotonin syndrome: a systematic review of 56 cases in the literature	25
41st International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) 25-28 May 2021, Virtual Meeting	24
A randomized trial comparing physostigmine vs lorazepam for treatment of antimuscarinic (anticholinergic) toxidrome	24
Extracorporeal membrane oxygenation use in poisoning: a narrative review with clinical recommendations	23
Amanitin intoxication: effects of therapies on clinical outcomes – a review of 40 years of reported cases	22
Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series	22

Extracorporeal treatment for calcium channel blocker poisoning: systematic review and recommendations from the EXTRIP workgroup	21
Systematic review on the use of activated charcoal for gastrointestinal decontamination following acute oral overdose	21
The early impact of paraquat ban on suicide in Taiwan	18
Dose-response relationships in aluminium toxicity in humans	17
Snakebite-associated thrombotic microangiopathy: an Australian prospective cohort study [ASP30]	17
Blood concentrations of synthetic cathinones	17
Variation of drugs involved in acute drug toxicity presentations based on age and sex: an epidemiological approach based on European emergency departments	17
Wastewater analysis for psychoactive substances at music festivals across New South Wales, Australia in 2019–2020	16
Methadone and suboxone^® mentions on twitter: thematic and sentiment analysis	16
Nitrous oxide abuse induced subacute combined degeneration despite patient initiated B12 supplementation	16
Evaluation of N-acetylcysteine dose for the treatment of massive acetaminophen ingestion	15
Methamphetamine exposures reported to United States poison control centers, 2000–2019	15
Respiratory failure in confirmed synthetic cannabinoid overdose	15
Does vitamin B12 deficiency explain psychiatric symptoms in recreational nitrous oxide users? A narrative review	14
Intentional pesticide poisoning and pesticide suicides in Nepal	14
Identification of a novel opioid, N-piperidinyl etonitazene (etonitazepipne), in patients with suspected opioid overdose	13
Death associated with brorphine, an emerging novel synthetic opioid	13
Sentanyl: a comparison of blood fentanyl concentrations and naloxone dosing after non-fatal overdose	12
The clinical toxicology of ketamine	12
New psychoactive substance cocktail in an intensive care intoxication case elucidated by molecular networking	12
Increased rates of diphenhydramine overdose, abuse, and misuse in the United States, 2005–2016	12
Letter in response to Rivastigmine for the treatment of anticholinergic delirium following severe procyclidine intoxication	12
Changes in California cannabis exposures following recreational legalization and the COVID-19 pandemic	12
Treating ethylene glycol poisoning with alcohol dehydrogenase inhibition, but without extracorporeal treatments: a systematic review	11
Moderate-to-severe Vipera berus envenoming requiring ViperaTAb antivenom therapy in the UK	11
Emergency department visits due to new psychoactive substances and other illicit drugs in Taiwan: preliminary results of the Taiwan Emergency Department Drug Abuse Surveillance (TEDAS) project	11
Death by hand sanitizer: syndemic methanol poisoning in the age of COVID-19	11
Vasodilation in patients with calcium channel blocker poisoning treated with high-dose insulin: a comparison of amlodipine versus non-dihydropyridines	11
Bowel obstruction following ingestion of superabsorbent polymers beads: literature review	11
Bites by the noble false widow spider Steatoda nobilis can induce Latrodectus-like symptoms and vector-borne bacterial infections with implications for public health: a case series	11
Synthetic cannabis: adverse events reported to the New Zealand Pharmacovigilance Centre	10
Ivermectin associated adverse events in the treatment and prevention of COVID-19 reported to the FACT pharmacovigilance project	10
Clinical experience with titrating doses of digoxin antibodies in acute digoxin poisoning. (ATOM-6)	10
Alterations in cerebral and cardiac mitochondrial function in a porcine model of acute carbon monoxide poisoning	10
Lipid emulsion for the treatment of acute organophosphate poisoning: an Open-Label randomized trial	10
Clinical symptoms and blood concentration of new psychoactive substances (NPS) in intoxicated and hospitalized patients in the Budapest region of Hungary (2018-19)	10
Pesticide use, agricultural outputs, and pesticide poisoning deaths in Japan	10
Clinical outcome of massive acetaminophen overdose treated with standard-dose N-acetylcysteine	10
Clinical and pathophysiological characteristics of valproate-induced pleural effusion	9
Transdermal buprenorphine for in-hospital transition from full agonist opioids to sublingual buprenorphine: a retrospective observational cohort study	9
Diquat poisoning in a pregnant woman resulting in a miscarriage and maternal death	9
Australian snakebite myotoxicity (ASP-23)	9
Distinguishing between toxic alcohol ingestion vs alcoholic ketoacidosis: how can we tell the difference?	9
Bites by exotic snakes reported to the UK National Poisons Information Service 2009–2020	9
Novel psychoactive substances-related presentations to the emergency departments of the European drug emergencies network plus (Euro-DEN plus) over the six-year period 2014–2019	9
Retained bullets and lead toxicity: a systematic review	9
An examination of fatal child poisonings in the United States using the National Violent Death Reporting System (NVDRS), 2012–2017	9
A cluster of tetrodotoxin poisoning in Oman	9
Efficacy of lipid emulsion therapy in treating cardiotoxicity from diphenhydramine ingestion: a review and analysis of case reports	8
Does the ICU Requirement Score allow the poisoned patient to be safely managed without admission to the intensive care unit? – a validation cohort study	8

The role of a point-of-care ultrasound protocol in facilitating clinical decisions for snakebite envenomation in Taiwan: a pilot study	8
Quantity of phenibut in dietary supplements before and after FDA warnings	8
Characteristics of ivermectin toxicity in patients taking veterinary and human formulations for the prevention and treatment of COVID-19	8
Differences in clinical features associated with cannabis intoxication in presentations to European emergency departments according to patient age and sex	8
Critical care interventions in children aged 6 months to 12 years admitted to the pediatric intensive care unit after unintentional cannabis exposures	8
Safety and effectiveness concerns of lopinavir/ritonavir in COVID-19 affected patients: a retrospective series	8
Analytically confirmed eutylone (bk-EBDB) exposure in emergency department patients	8
Trends in intentional abuse and misuse ingestions in school-aged children and adolescents reported to US poison centers from 2000-2020	8
Clinical and patient characteristics associated with severe outcome in diphenhydramine toxicity	8
Pediatric suicides reported to U.S. poison centers	8
Trends of prescription psychotropic medication exposures in pediatric patients, 2009–2018	8
Suspected Fanconi syndrome from cadmium toxicity exacerbated by heavy kratom use. A rare occurrence	7
Evaluating the impact of home quarantine during the coronavirus pandemic on pediatric exploratory ingestions	7
Synthetic cannabinoid poisonings and access to the legal cannabis market: findings from US national poison centre data 2016–2019	7
Descriptive epidemiology of clinically significant occupational poisonings, United States, 2008–2018	7
A cluster of lysergic acid diethylamide (LSD) poisonings following insufflation of a white powder sold as cocaine	7
Poisoning in older adults: characterization of exposures reported to the Dutch Poisons Information Center	7
Clinical and pathological characteristics of acute kidney injury caused by diquat poisoning	7
Severe intentional sodium nitrite poisoning is also being seen in France	7
Effect of the first wave of COVID-19 on Poison Control Centre activities in 21 European countries: an EAPCCT initiative	7
Fomepizole as an adjunctive therapy for acetaminophen poisoning: cases reported to the toxicology investigators consortium (ToxIC) database 2015–2020	7
Factors associated with seizure development after bupropion overdose: a review of the toxicology investigators consortium	7
Impact of marijuana legalization on cannabis-related visits to the emergency department	7
Severe Heloderma spp. envenomation: a review of the literature	7
Comparison of clinical characteristics between meth/amphetamine and synthetic cathinone users presented to the emergency department	6
Suspected suicides and nonfatal suicide attempts involving antidepressants reported to United States poison control centers, 2000–2020	6
Epidemiology of scorpionism in France: nationwide scorpion exposure	6
Characteristics of fatal gabapentinoid-related poisoning in Australia, 2000–2020	6
Clinical features associated with ADB-BUTINACA exposure in patients attending emergency departments in England	6
Predicting serotonin toxicity in serotonin reuptake inhibitor overdose	6
Single bag high dose intravenous N-acetylcysteine associated with decreased hepatotoxicity compared to triple bag intravenous N-acetylcysteine in high-risk acetaminophen ingestions	6
Genetic variants associated with ALT elevation from therapeutic acetaminophen	6
Hyperammonemia in acetaminophen toxicity	6
Silibinin: a toxicologist’s herbal medicine?	6
Performance of the paracetamol-aminotransferase multiplication product in risk stratification after paracetamol (acetaminophen) poisoning: a systematic review and meta-analysis	6
Acute toxicity from the synthetic cathinone N-ethylpentylone (ephylone) in the United Kingdom	6
International trends in systemic human exposures to 2,4 dinitrophenol reported to poisons centres	6
Changes in unintentional cannabis exposures in children 6 months to 5 years reported to United States poison centers during the first nine months of the coronavirus-19 pandemic	6
A cluster of 25B-NBOH poisonings following exposure to powder sold as lysergic acid diethylamide (LSD)	6
Detection of flubromazolam in patients with suspected non-medical drug use attending emergency departments in the United Kingdom	6
Hospital encounters for pediatric ingestions before and during the COVID-19 pandemic	6
Poison center consultation reduces hospital length of stay	6
Suspected suicides and suicide attempts involving antipsychotic or sedative-hypnotic medications reported to America’s Poison Centers, 2000–2021	6
Relative safety and quality of various dietary supplement products U.S. Service Members ask about	6
Is secondary chemical exposure of hospital personnel of clinical importance?	6
The unapproved drug centrophenoxine (meclofenoxate) in cognitive enhancement dietary supplements	6
Lead poisoning due to incense burning: an outbreak in a family	6
Internet-assisted suicide by nitrite poisoning – a case report and increase in reported intentional nitrite/nitrate exposures in U.S. Poison Center data	6
Opioid exposure associated with poppy consumption reported to poison control centers and the U.S. Food and Drug Administration	6
N-desethyl isotonitazene detected in polydrug users admitted to hospital in Birmingham, United Kingdom	6
Thiocyanate toxicity: a teaching case	6
Coagulopathy after snake envenomation in South Korea	6
Increase in pregabalin recreational use in adolescents in France	6
The clinical course and treatment of black mamba (Dendroaspis polylepis) envenomations: a narrative review	6
Metabolomic markers predictive of hepatic adaptation to therapeutic dosing of acetaminophen	5
Early recovery of botulism: one decade of experience	5
Severe toxicity involving N-pyrrolidino etonitazene in the United Kingdom—a case report	5
Impaired neuromuscular function by conjoint actions of organophosphorus insecticide metabolites omethoate and cyclohexanol with implications for treatment of respiratory failure	5
Dose-related hypoglycemia in venlafaxine poisoning: a retrospective cohort study	5
Disposition of toxic drugs and chemicals in man	5
Clinical effects and factors associated with adverse clinical outcomes of hymenopteran stings treated in a Thai Poison Centre: a retrospective cross-sectional study	5
Unintentional buprenorphine and methadone poisoning in children: a matched observational study	5
Accuracy of substance exposure history in patients attending emergency departments after substance misuse; a comparison with biological sample analysis	5
Epidemiology of poisoning in Syria (1999 through 2020)	5
Clinical presentation of type 1 and type 2 pyrethroid poisoning in humans	5
Neurotoxic effects of nephrotoxic compound diethylene glycol	5
A two-bag acetylcysteine regimen is associated with shorter delays and interruptions in the treatment of paracetamol overdose	5
Cannabidiol exposures in the United States, National Poison Data System, July 2014–June 2021	5
Cocaine exposures reported to United States poison control centers, 2000–2020	5
Involuntary MDMB-4en-PINACA intoxications following cannabis consumption: clinical and analytical findings	5
Dexamethasone therapy prevents delayed neuropsychiatric sequelae after carbon monoxide poisoning: a prospective registry-based study	5
Management of caustic ingestion: the time has come for consensus guidelines	5
Metformin-associated lactic acidosis reported to the United Kingdom National Poisons Information Service (NPIS) between 2010 and 2019: a ten-year retrospective analysis	5
Continuation of outpatient buprenorphine therapy after dispensing Buprenorphine-Naloxone from the emergency department	5
Effect of plasma exchange on colchicine elimination in overdose – a case report	5
Manganese concentration in patients with encephalopathy following ephedrone use: a narrative review and analysis of case reports	5
Rates and types of urine drug screen false negative results compared with confirmatory toxicology testing in major trauma patients	5
CAR-T and checkpoint inhibitors: toxicities and antidotes in the emergency department	5
Intentional avermectin pesticide ingestion: a retrospective multicenter study	5
Role of age-sex as underlying risk factors for death in acute pesticide self-poisoning: a prospective cohort study	4

Validation of a nomogram used to predict lithium concentration in overdose	4
Sodium bicarbonate treatment for QRS widening in bupropion overdoses	4
The acute paraquat poisoning mortality (APPM) score to predict the risk of death in paraquat-poisoned patients	4
Oral potassium overdose: a case series	4
Haff disease associated with consumption of buffalofish (Ictiobusspp.) in the United States, 2010–2020, with confirmation of the causative species	4
Closing the xylazine knowledge gap	4
Population pharmacokinetics of Pseudechis porphyriacus (red-bellied black snake) venom in snakebite patients	4
Qualitative and quantitative characteristics of xylazine-associated deaths detected using a post-mortem toxicology testing program	4
Delayed cardiotoxicity in venlafaxine and quetiapine overdose	4
Effectiveness of multiple-dose activated charcoal in lamotrigine poisoning: a case series	4
Methyl mercaptan gas: mechanisms of toxicity and demonstration of the effectiveness of cobinamide as an antidote in mice and rabbits	4
A case of fatal paralytic shellfish poisoning in Alaska	4
Independent validation of the Tanta University Risk Model for intensive care requirement in acutely poisoned adults	4
Continuous extracorporeal clearance in metformin-associated lactic acidosis and metformin-induced lactic acidosis: a systematic review	4
Are antimuscarinic effects common in hydroxyzine overdose? A cohort analysis of antimuscarinic effects in hydroxyzine and diphenhydramine-poisoned patients	4
A cluster of acute thebaine poisonings from non-food grade poppy seeds in the Australian food supply	4
Predictors of FabAV use in copperhead envenomation	4
E-cigarette or vaping-associated lung injury (EVALI): a review of international case reports from outside the United States of America	4
A systematic review of second line therapies in toxic seizures	4
American College of Medical Toxicology and the American Academy of Clinical Toxicology position statement: nalmefene should not replace naloxone as the primary opioid antidote at this time	4
Lipid emulsion facilitates reversal from volatile anesthetics in a rodent model	4
Major component causing neurological toxicity in acute glufosinate ammonium poisoning: determination of glufosinate, 1-methoxy-2-propanol, and ammonia in serum and cerebrospinal fluid	4
Population pharmacokinetic analysis of acetaminophen overdose with immediate release, extended release and modified release formulations	4
Beverage ethanol exposures among infants reported to United States poison control centers	4
Successful treatment of potentially lethal dose thallium sulfate poisoning with sequential use of Prussian blue and multiple-dose activated charcoal	4
Mercury-associated neural epidermal growth factor-like 1 protein (NELL-1) positive membranous nephropathy after use of skin lightening creams	4
Accidental poisoning with autumn crocus ( Colchicum autumnale ): a case series	4
Massive tramadol ingestion resulting in fatal brain injury – a pharmacokinetic study with discussion on the involved mechanisms of toxicity	4
Evaluation of the relationship of xylazine and fentanyl blood concentrations among fentanyl-associated fatalities	4
Lipid emulsion therapy during management of the critically-ill poisoned patient: a prospective cohort study	4
Development of sodium tetrathionate as a cyanide and methanethiol antidote	4
Relationship between acute kidney injury and mortality in poisoning – a systematic review and metanalysis	4
Acquired methemoglobinemia in children presenting to Italian pediatric emergency departments: a multicenter report	4
Intravenous rifampicin use in the management of amanita phalloides toxicity	4
Human poisonings by neurotoxic phycotoxins related to the consumption of shellfish: study of cases registered by the French Poison Control Centres from 2012 to 2019	4
Birth outcomes in women exposed to diagnostic radiology procedures during first trimester of pregnancy: a prospective cohort study	4
Acute coronary syndrome from scombroid poisoning: a narrative review of case reports	4
Prevalence of positive toxicology analysis from the French national registry for sudden unexpected infant death (Tox-MIN)	3
Characteristics and circumstances of volatile solvent misuse-related death in Australia, 2000–2021	3
Late hemotoxicity following North American rattlesnake envenomation treated with crotalidae immune F(ab’)₂ (equine) antivenom and crotalidae immune polyvalent Fab (ovine) antivenom reported	3
The association of amfetamines and cathinones with acute coronary syndrome – a systematic review	3
Dose ingested, vomiting, and outcome in patients ingesting a standard paraquat 20SL formulation	3
Comment on: Amanitin intoxication	3
The serum glycolate concentration: its prognostic value and its correlation to surrogate markers in ethylene glycol exposures	3
Blood cannabinoid molar metabolite ratios are superior to blood THC as an indicator of recent cannabis smoking	3
Skeletal fluorosis secondary to harmful inhalant use	3
Olanzapine/samidorphan precipitated opioid withdrawal in a patient taking transdermal fentanyl	3
A case report of Ovophis makazayazaya envenoming	3
Reversal of ingested fentanyl patch toxicity with oral naltrexone in remote Australia: case report	3
National assessment of anti-epileptic drug exposures among pre-teens and adolescents, 2000–2020	3
Tapentadol exposures and poisonings in Australia	3
COVID-19 lockdowns and incidence of psychoactive substance exposure according to age and sex	3
Pediatric poison exposures reported to United States poison centers before and during the COVID-19 pandemic	3
COVID-19 and contamination: impact on exposures to alcohol-based hand sanitizers reported to Texas Poison Control Centers, 2020	3
Trends and correlates of discordant reporting of drug use among nightclub/festival attendees, 2019–2022	3
An outbreak of severe coagulopathy in northern Israel among users of illicit synthetic cannabinoids adulterated with brodifacoum	3
Carbon monoxide poisoning mortality in the United States from 2015–2021	3
Pregnancy outcome after early exposure to nivolumab, a PD-1 checkpoint inhibitor for relapsed Hodgkin’s lymphoma	3
Minding the osmol gap: a sentinel event and subsequent laboratory investigation	3
Effect of Agkistrodon halys antivenom in patients bit by green pit viper and the prognostic role of the disease – a retrospective cohort study	3
Fatal and life-threatening ADRs associated with paliperidone palmitate: an observational study in the French pharmacovigilance database	3
Factors associated with prolonged intensive care stay among self-poisoned patients	3
Minoxidil overdose with hypotension effectively managed with norepinephrine, rather than dopamine	3
Clinical and electrocardiographic factors associated with adverse cardiovascular events in bupropion exposures	3
Comment on epidemiology of scorpionism in France: nationwide scorpion exposure. Description of Buthus pyrenaeus envenoming	3
Lentiform fork sign in a uremic patient after inadvertent exposure to metformin	3
Characteristics of emergency department presentations following ingestion of Taxus baccata (yew)	3
Anticholinergic syndrome after atropine overdose in a supposedly homeopathic solution: a case report	3
Marked and prolonged serotonin toxicity in a tramadol-poisoned patient with a pharmacokinetic study	3
Massive suicidal ingestion of caffeine: a case report with investigation of the cardiovascular effect/concentration relationships	3
An outbreak of mushroom poisoning in Israel during the 2020 fall and winter season: an unexpected outcome of COVID-19 restrictions?	3
Thromboelastography in the setting of acetaminophen-induced hepatotoxicity	3
Cannabis positivity rates in 17 emergency departments across the United States with varying degrees of marijuana legalization	3
Exposure reasons, other substance use, and medical outcomes of poison control center cases aged 50+ involving opioids, 2015–2020	3
Comparing development of liver injury using the two versus three bag acetylcysteine regimen despite early treatment in paracetamol overdose	3
Unwitting adult marijuana poisoning: a case series	3
Echis coloratus envenomation in children: a retrospective case series	3
Characteristics of pepper spray-related injuries reported to the National Electronic Injury Surveillance System during 2000–2020	3
An outbreak of Amanita exitialis poisoning	3
Effect of new legislation in Germany on prevalence and harm of synthetic cannabinoids	3
North American Congress of Clinical Toxicology (NACCT) Abstracts 2021	3
Do mnemonics help healthcare professionals learn and recall cholinergic toxidromes?	3
Dexmedetomidine in the treatment of toxicologic conditions: a systematic review and review of the toxicology investigators consortium database	3
N-Acetylcysteine treatment of neonatal acetaminophen toxicity caused by transplacental transfer – a case report	3
Trends and characteristics of ocular exposures related to e-cigarettes and e-liquids reported to Poison Control Centers in the United States, 2010–2019	3
Pharmacobezoar after overdose of isoniazid and rifampin	3
Use of Crotalidae equine immune F(ab’)₂ antivenom for treatment of an Agkistrodon envenomation	3
Diethylene glycol produces nephrotoxic and neurotoxic effects in female rats	3
Evidence for the efficacy of the emetic PP796 in paraquat SL20 formulations – a narrative review of published and unpublished evidence	3
Seniors and single-use detergent sacs (SUDS): a review of the National Poison Data System from 2012 to 2020	3
The minor cannabinoid cannabigerol (CBG) is a highly specific blood biomarker of recent cannabis smoking	3
Fomepizole dosing during continuous renal replacement therapy – an observational study	3
The Poison Center as a pandemic response: establishment and characteristics of a COVID-19 hotline through the New Jersey Poison Center	3
Emerging synthetic cannabinoids detected by a drug checking service in Toronto, Canada	3
Retrospective evaluation of management guidelines for extracorporeal treatment of metformin poisoning	2