OOIR: Observatory of International Research

Papers

(The TQCC of ACS Chemical Biology is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Introducing Our Authors	142
Discovery and Validation of a Novel Class of Necroptosis Inhibitors Targeting RIPK1	90
Multi-TACs: Targeting Solid Tumors with Multiple Immune Cell Co-engagers	76
Correction to “Characterization of the Iron–Sulfur Cluster in the NCOA4 Fragment (383–522) and Its Interaction with Ferritin”	57
Issue Publication Information	52
Issue Editorial Masthead	51
In Situ Labeling of Pathogenic Tau Using Photo-Affinity Chemical Probes	50
Biosynthesis of Physcion and Identification of an O-Methyltransferase with C6–OH Selectivity in Aspergillus chevalieri BYST01	49
Enzymatic Macrolactamization of mRNA Display Libraries for Inhibitor Selection	47
Enzymatic Pathway for Kupyaphore Degradation in Mycobacterium tuberculosis: Mechanism of Metal Homeostasis and Turnover	45
Simple Enzymatic Incorporation of 2′OMeU Nucleotide at the End of the Poly-A Tail for Enhancement of the mRNA Stability and Protein Expression	43
Molecular Targeted Engagement of DPP9 in Rat Tissue Using CETSA, SP3 Processing, and Absolute Quantitation Mass Spectrometry	42
Chemical Synthetic Lethality Screens Identify Selective Drug Combinations against Pseudomonas aeruginosa	42
Dynamic Regulation of 5-Formylcytidine on tRNA	41
A Robust α-l-Fucosidase from Prevotella nigrescens for Glycoengineering Therapeutic Antibodies	39
Spatiotemporal Proximity Labeling Tools to Track GlcNAc Sugar-Modified Functional Protein Hubs during Cellular Signaling	39
Li-BrU-seq: A Low-Input and Simplified Metabolic Labeling Method for Nascent RNA Sequencing	38
Exploring Metalloproteome Remodeling in Calprotectin-Stressed Acinetobacter baumannii Using Chemoproteomics	37
Structural and Biochemical Insights into Lignin-Oxidizing Activity of Bacterial Peroxidases against Soluble Substrates and Kraft Lignin	36
An Inherent Difference between Serine and Threonine Phosphorylation: Phosphothreonine Strongly Prefers a Highly Ordered, Compact, Cyclic Conformation	36
Ferroptosis Inhibitors Suppress Prostaglandin Synthesis in Lipopolysaccharide-Stimulated Macrophages	35
Reengineering of Circularly Permuted Caspase-2 to Enhance Enzyme Stability and Enable Crystallographic Studies	34
Cell-Impermeable Hsp90α-Selective Inhibitor NDNA4 Inhibits Cancer Cell Migration and Targets Extracellular Hsp90α’s Critical F-5 Fragment	32
Robust Chemoenzymatic Synthesis of Keratinimicin Aglycone Analogues Facilitated by the Structure and Selectivity of OxyB	32
Self-Avoiding Gamma Peptide Nucleic Acids for Selective Targeting of RNA Secondary Structures	32

HiBiT-SpyTag: A Minimal Tag for Covalent Protein Capture and Degrader Development	32
Target-Responsive DNA Hydrogels with Encapsulation and Release Properties Using Programmable CRISPR-Cas12a	31
A Nonfunctional Halogenase Masquerades as an Aromatizing Dehydratase in Biosynthesis of Pyrrolic Polyketides by Type I Polyketide Synthases	31
Mechanistic Studies on Dehydration in Class V Lanthipeptides	30
Antimicrobial Lasso Peptide Cloacaenodin Utilizes a Unique TonB-Dependent Transporter to Access Susceptible Bacteria	30
Repurposing of the RIPK1-Selective Benzo[1,4]oxazepin-4-one Scaffold for the Development of a Type III LIMK1/2 Inhibitor	29
Covalent Catalytic Strategies for Enzymes That Modify RNA Molecules on their Tripartite Building Blocks	28
Sec Signal Peptide Doubles Up as a Leader Sequence in Bufferin Biosynthesis	28
Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization	27
Issue Editorial Masthead	27
Issue Editorial Masthead	27
Laboratory Evolution of Metalloid Reductase Substrate Recognition and Nanoparticle Product Size	27
Issue Publication Information	27
Christopher T. Walsh: A Prolific Scientist, Effective Academic Leader, and Responsive Mentor	27
MYC-Targeting PROTACs Lead to Bimodal Degradation and N-Terminal Truncation	27
Labeling of CC Chemokine Receptor 2 with a Versatile Intracellular Allosteric Probe	27
Issue Publication Information	27
Clotrimazole-Based Modulators of the TRPM3 Ion Channel Reveal Narrow Structure–Activity Relationship	26
Analysis of the Valgamicin Biosynthetic Pathway Reveals a General Mechanism for Cyclopropanol Formation across Diverse Natural Product Scaffolds	26
Exploring Protein S-Palmitoylation: Mechanisms, Detection, and Strategies for Inhibitor Discovery	26
An RNA Methylation-Sensitive AIEgen-Aptamer Reporting System for Quantitatively Evaluating m⁶A Methylase and Demethylase Activities	25
Chemical Probes that Target a Dissociative LuxR-Type Quorum Sensing Receptor in Gram-Negative Bacteria	25
Engineering a Low-Immunogenic Mirror-Image VHH against Vascular Endothelial Growth Factor	25
Photoactivatable Plant Hormone-Based Chemical Inducers of Proximity for In Vivo Applications	25
Structure–Activity Relationships of Anabaenopeptins as Carboxypeptidase and Phosphatase Inhibitors	25
2-Cyanopyrimidine-Containing Molecules for N-Terminal Selective Cyclization of Phage-Displayed Peptides	25
Small-Molecule FICD Inhibitors Suppress Endogenous and Pathologic FICD-Mediated Protein AMPylation	25
Chemical Genetics in C. elegans Identifies Anticancer Mycotoxins Chaetocin and Chetomin as Potent Inducers of a Nuclear Metal Homeostasis Response	25
Inhibitors of the PqsR Quorum-Sensing Receptor Reveal Differential Roles for PqsE and RhlI in Control of Phenazine Production	25
Lanmodulin’s EF 2–3 Domain: Insights from Infrared Spectroscopy and Simulations	24
What Is the Crystallographic Resolution of Structural Models of Proteins Generated with AlphaFold2?	24
Phage Display Selection against a Mixture of Protein Targets	24
Targeted Discovery of Cryptic Enediyne Natural Products via FRET-Coupled High-Throughput Elicitor Screening	24
ATP Regeneration by Polyphosphate Kinase Powers Efficient Oligosaccharide Synthesis Catalyzed by Glycoside Phosphorylases	24
Light-Inducible Activation of TrkA for Probing Chronic Pain in Mice	24
Issue Editorial Masthead	24
Design of Class I/IV Bromodomain-Targeting Degraders for Chromatin Remodeling Complexes	24
Bioproduction of a Large-Scale Library of Tryptamine Derivatives for Neuropsychiatric Drug Screening	23
Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective Modulators	23
Taxodione Inhibits Glioblastoma Proliferation and Potentiates the Cytotoxicity of Paclitaxel	23
PPARγ Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles	23
Synthesis and Properties of RNA Modified with Cationic Amine Internucleoside Linkage	23
Native Aminoacyl-tRNA Synthetase/tRNA Pair Drives Highly Efficient Noncanonical Amino Acid Incorporation in Escherichia coli	23
Genome-Guided Discovery of the Myxobacterial Thiolactone-Containing Sorangibactins	22
Fitness Landscape-Guided Engineering of Locally Supercharged Virus-like Particles with Enhanced Cell Uptake Properties	22
SETDB1 Triple Tudor Domain Ligand, ( R , R )-59, Promotes Methylation of Akt1 in Cells	22
Evaluation of Thiosaccharides as Carbohydrate-Based Slow-Releasing Hydrogen Sulfide Donors	22
Structures of Methanomethylophilus alvus Pyrrolysine tRNA-Synthetases Support the Need for De Novo Selections When Altering the Substrate Specificity	22
Bifunctional Sesquiterpene/Diterpene Synthase Agr2 from Cyclocybe aegerita Gives Rise to the Novel Diterpene Cyclocybene	22
Tryptamine Metabolism and Functionalization in Gut Commensal Bacteria Expand Human Tryptamine Signaling Responses	22

Evaluating Linker Architecture in RNA-Detecting Riboglow Probes and Effects on Fluorescence Turn-On	22
Photocaged Chloroquine Derivatives for the Light-Dependent Inhibition of Autophagy in Cancer Stem Cells	22
A Novel Lysosome Targeting Chimera for Targeted Protein Degradation via Split-and-Mix Strategy	22
A Multi-Split-and-Mix Platform for a Variety of Targeted Protein Degradation	21
Endogenous ROS-Mediated Covalent Immobilization of Gold Nanoparticles in Mitochondria: A “Sharp Sword” in Tumor Radiotherapy	21
Insights into Substrate Recognition by the Unusual Nitrating Enzyme RufO	20
A Plastic Biosynthetic Pathway for the Production of Structurally Distinct Microbial Sunscreens	20
Beyond KRAS(G12C): Biochemical and Computational Characterization of Sotorasib and Adagrasib Binding Specificity and the Critical Role of H95 and Y96	20
Identification of Rapaglutin E as an Isoform-Specific Inhibitor of Glucose Transporter 1	20
Optimizing Peptide-Conjugated Lipid Nanoparticles for Efficient siRNA Delivery across the Blood–Brain Barrier and Treatment of Glioblastoma Multiforme	20
In Silico Discovery of Group II Intron RNA Splicing Inhibitors	20
Widespread, Reversible Cysteine Modification by Methylglyoxal Regulates Metabolic Enzyme Function	20
Biosynthesis of the Azoxy Compound Azodyrecin from Streptomyces mirabilis P8-A2	20
Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5	20
Dynamic S -Acylation of GSDMA Regulates Pyroptosis	19
Drug-Like Small Molecules That Inhibit Expression of the Oncogenic MicroRNA-21	19
Correction to “Analysis of the Sequence Preference of Saporin by Deep Sequencing”	19
Issue Editorial Masthead	19
Multiparametric High-Content Cell Painting Identifies Copper Ionophores as Selective Modulators of Esophageal Cancer Phenotypes	19
Genome Mining of Sphingopyxis sp. MG Uncovers an Enzyme with Dual Catalytic Activity of Haloalkane Dehalogenase and Epoxide Hydrolase	19
Chemical Approaches To Investigate Post-transcriptional RNA Regulation	19
Issue Editorial Masthead	19
Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct	19
Comparative Analysis of Drug-like EP300/CREBBP Acetyltransferase Inhibitors	19
Enzymatic Bromination of Native Peptides for Late-Stage Structural Diversification via Suzuki–Miyaura Coupling	19
Insights into Free Drug Release from Efficacious N-Acyl O-Aminophenol Duocarmycin Prodrugs	19
Issue Publication Information	19
Site-Specific Introduction of Alanines for the Nuclear Magnetic Resonance Investigation of Low-Complexity Regions and Large Biomolecular Assemblies	18
Multimodal Blood-Based Biomarker Panel Reveals Altered Lysosomal Ionic Content in Alzheimer’s Disease	18
Structural, Biochemical, and Bioinformatic Basis for Identifying Radical SAM Cyclopropyl Synthases	18
Mapping snoRNA Targets Transcriptome-Wide with snoKARR-seq	18
In Vivo Metabolic Labeling with an Isoprenoid Probe Reveals APOE Allele-Specific Differences in the Prenylome	18
G Protein-Biased Agonists for Intracellular Angiotensin Receptors Promote Collagen Secretion in Myofibroblasts	18
Characterization of Chemical Interactions between Clinical Drugs and the Oral Bacterium, Corynebacterium matruchotii, via Bioactivity-HiTES	18
Chemoenzymatic Probes Reveal Peptidoglycan Recognition and Uptake Mechanisms in Candida albicans	17
Discovery of a Compound That Inhibits IRE1α S-Nitrosylation and Preserves the Endoplasmic Reticulum Stress Response under Nitrosative Stress	17
The Relationship between Substrate Structure and Selectivity of Ketoreduction in Multimodular Polyketide Synthases: A Comparative Study of A-Type Ketoreductases from Late Modules Using Complex Precurs	17
Chemical Probe Approach Reveals Endo-α-mannosidase Triages Misfolded Glycoproteins in the Calnexin/Calreticulin Cycle	17
Pathogenic SNPs Affect Both RNA and DNA G-Quadruplexes’ Responses to Ligands	17
Chemoproteomic Profiling Reveals the Mechanism of Bile Acid Tolerance in Bacteria	17
Phage Selection of Cyclic Peptides Inhibiting Aminoglycoside Phosphotransferases to Control Resistant Bacteria	17
Authentic Phosphorylation of α-Synuclein at Ser129 Reveals Functional Differences Not Captured by the S129D Phosphomimetic	17
Genome Mining of Myxopeptins Reveals a Class of Lanthipeptide-Derived Linear Dehydroamino Acid-Containing Peptides from Myxococcus sp. MCy9171	17
Advances in Optogenetics and Thermogenetics for Control of Non-Neuronal Cells and Tissues in Biomedical Research	16
Metabolic Glycan Labeling in Primary Neurons Enabled by Unnatural Sugars with No S-Glyco-Modification	16
Biphasic Cellular Response Triggered by Tetrandrine-Mediated Dysfunction and Lysophagic Clearance of Lysosomes	16
Correction to “A cAMP Sensor Based on Ligand-Dependent Protein Stabilization”	16
Natural Product-Derived Ianthelliformisamines Inhibit Protein Translation and Block Bacterial Flagellum Assembly	16
Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity	16
Discovery of Small-Molecule Inhibitors of the Pycsar Antiphage Defense	16
Issue Publication Information	16
Screen for Modulation of Nucleocapsid Protein Condensation Identifies Small Molecules with Anti-Coronavirus Activity	16
Multivalent Peptide-DNA Conjugates Facilitate DNA Internalization in Cells Expressing Glycosaminoglycans	16
Stable Isotope-Guided Metabolomics Reveals Polar-Functionalized Fatty-Acylated RiPPs from Streptomyces	16
Development of Comprehensive Screening and Assessment Assays for Small-Molecule Ligands of MALAT1 lncRNA	16
Issue Publication Information	16
Adenylation Domain-Guided Recruitment of Trans-Acting Nonheme Monooxygenases in Nonribosomal Peptide Biosynthesis	15
The Impact of Sugar Conformation on the Single-Stranded DNA Selectivity of APOBEC3A and APOBEC3B Enzymes	15
Modulation of Core-Fucosylation Oxidation for Selective Enrichment and Characterization of Cell Surface Glycoprotein	15
A Fluorescence Polarization Assay for Macrodomains Facilitates the Identification of Potent Inhibitors of the SARS-CoV-2 Macrodomain	15
High-Throughput Activity Reprogramming of Proteases (HARP)	15
Design, Synthesis, and Mechanistic Studies of (R)-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase	15
Borinic Acid-Based Fluorogenic Probes as an Alternative to the Amplex Red Assay for Real-Time H₂O₂ Monitoring in Live Cells	15
Structural Insights into Spare-Tire DNA G-Quadruplex from the Human VEGF Promoter	15
Identification of Chemical Probes Targeting MBD2	15
Drugging the Sarcomere, a Delicate Balance: Position of N-Terminal Charge of the Inhibitor W7	15
Omniligase-1-Mediated Phage-Peptide Library Modification and Insulin Engineering	15
Protein-Labeling Reagents Selectively Activated by Copper(I)	15
Introducing Our Authors	15
CRISPR RiPCA for Investigating eIF4E-m⁷GpppX Capped mRNA Interactions	15
Targeted Protein Degradation through Recruitment of the CUL4 Complex Adaptor Protein DDB1	15
Visualizing Intracellular Localization of Natural-Product-Based Chemical Probes Using Click-Correlative Light and Electron Microscopy	15
Decoding Protein–Peptide Interactions Using a Large, Target-Agnostic Yeast Surface Display Library	15
Elucidating the Ferroptotic Black Box: Radical-Trapping Antioxidant Probes Illuminate Subcellular Onset and Progression	15
Elucidating the Role of the Competence Regulon Quorum Sensing Circuitry in Streptococcus cristatus	15
Dual-Probe Activity-Based Protein Profiling Reveals Site-Specific Differences in Protein Binding of EGFR-Directed Drugs	15
Uncovering the Association Mechanism between Two Intrinsically Flexible Proteins	15
Discovery and Mechanism of 16–19F, a Novel Synthetic Lethal Inhibitor of the PRMT5•MTA Complex in MTAP-Deleted Cancer Cells	15
Mechanistic Analysis of Bioorthogonal Double Strain-Promoted Alkyne–Nitrone Cycloadditions Involving Dibenzocyclooctadiyne	15
Enhancing the Anticancer Activity of Attenuated Listeria monocytogenes by Cell Wall Functionalization with “Clickable” Doxorubicin	15

Fungal NRPS-PKS Hybrid Enzymes Biosynthesize New γ-Lactam Compounds, Taslactams A-D, Analogous to Actinomycete Proteasome Inhibitors	14
Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the Chemokine Receptor CCR2	14
Reversible Antagonism of Dopamine D1 Receptor Using a Photoswitchable Remotely Tethered Ligand	14
The Endoplasmic Reticulum-Located TRPV1 Channel Is Not Thermal Sensitive	14
New High-Throughput Screen Discovers Novel Ligands of Full-Length Nuclear Receptor LRH-1	14
Switching Prenyl Donor Specificities in Squalene Synthase-Like Aromatic Prenyltransferases from Bacterial Carbazole Alkaloid Biosynthesis	14
Rapid Evaluation of Staple Placement in Stabilized α Helices Using Bacterial Surface Display	14
microRNAs Regulate Cellular Magnesium by Tuning Expression of the Plasma Membrane Protein CNNM4	14
Cytochrome P450 Mining for Bufadienolide Diversification	14
Neurotoxic Implications of Human Coronaviruses in Neurodegenerative Diseases: A Perspective from Amyloid Aggregation	14
Introducing Our Authors	14
Studies Pertaining to the Emerging Cannabinoid Hexahydrocannabinol (HHC)	14
Decay of Piwi-Interacting RNAs in Human Cells Is Primarily Mediated by 5′ to 3′ Exoribonucleases	14
Structural Insights and Reaction Profile of a New Unspecific Peroxygenase from Marasmius wettsteinii Produced in a Tandem-Yeast Expression System	14
Selection of Optimal Cell Lines for High-Content Phenotypic Screening	14
Biosynthesis of Bacillus Phosphonoalamides Reveals Highly Specific Amino Acid Ligation	14
Phage Display of Two Distinct Warheads to Inhibit Challenging Proteins	14
Manipulation of Global Regulator mcrA Activates the Fumigermin Pathway in Penicillium camemberti IMV00769	14
Engineering H₂S-Activatable Aptameric Binders for Tailored Cell Manipulation	14
Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an S_Ni Mechanism and Ion Pair Transition State	14
A Repurposed Drug Interferes with Nucleic Acid to Inhibit the Dual Activities of Coronavirus Nsp13	14
Targeting Protein Interaction Hotspots Using Structured and Disordered Chimeric Peptide Inhibitors	14
Real-Time Cellular Thermal Shift Assay to Monitor Target Engagement	14
Class IIb Microcin MccM Interferes with Oxidative Phosphorylation in Escherichia coli	14
A Tandem-Affinity Purification Method for Identification of Primary Intracellular Drug-Binding Proteins	14
Novel Substrate Prediction for the TAM Family of RTKs Using Phosphoproteomics and Structure-Based Modeling	14
Issue Publication Information	14
DNA-Encoded Library Technology─A Catalyst for Covalent Ligand Discovery	13
fpocketR : A Platform for Identification and Analysis of Ligand-Binding Pockets in RNA	13
Localized Light-Triggered CO Delivery: Comparing the Amount of CO Delivered and Cellular Toxicity	13
Cooperative Membrane Damage as a Mechanism for Pentamidine–Antibiotic Mutual Sensitization	13
General Approach to Identify, Assess, and Characterize Inhibitors of Lipid Peroxidation and Associated Cell Death	13
4″-Methyl- S -Adenosyl- l -Methionines Are Substrates for 4-Methylazetidinecarboxylic Acid Synthases	13
MicroED as a Powerful Tool for Structure Determination of Macrocyclic Drug Compounds Directly from Their Powder Formulations	13
A Scavenger Hunt for a DyP-Peroxidase from a Metagenome: Curated Peroxidase Database-Assisted Primer Design and Protein Structure Elucidation	13
Selective Targeting of Protein Arginine Methyltransferase 1 (PRMT1) Mutant Activity by a Small Molecule Activation Strategy	13
Metabolic Investigation and Auxiliary Enzyme Modelization of the Pyrrocidine Pathway Allow Rationalization of Paracyclophane-Decahydrofluorene Formation	13
Regulatory and Catalytic Domains of Poly(ADP-ribose) Polymerases Cross-Complement for DNA-Break-Dependent Allosteric Stimulation of Catalytic Activity	13
Development of a New DHFR-Based Destabilizing Domain with Enhanced Basal Turnover and Applicability in Mammalian Systems	13
Discovery of Cyclic Lipopeptides Ralstopeptins A and B from Ralstonia solanacearum Species Complex and Analysis of Biosynthetic Gene Evolution	13
Controlling Tricyclic Peptide Architecture in mRNA Display through Orthogonal Reactivity on Rotationally Flexible Scaffolds	13
Kinetic and Thermodynamic Insights into Agonist Interactions with the Parathyroid Hormone Receptor-1 from a New NanoBRET Assay	13
Introducing Our Authors	13
Machine Learning Uncovers Natural Product Modulators of the 5-Lipoxygenase Pathway and Facilitates the Elucidation of Their Biological Mechanisms	13
Leveraging Covalency to Stabilize Ternary Complex Formation For Cell–Cell “Induced Proximity”	13
Acarbose May Function as a Competitive Exclusion Agent for the Producing Bacteria	13
A Bispecific Antibody Engineering Strategy for Effective Dual-Target Degradation of Cell-Surface and Secreted Oncoproteins with Superior Antitumor Activity	13
Donor-PeT Control of Intersystem Crossing Enables ALDH1A1-Activated Photodynamic Therapy	12
Generating Efficient Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetases for Structurally Diverse Non-Canonical Amino Acids	12
European Robin Cryptochrome-4a Associates with Lipid Bilayers in an Ordered Manner, Fulfilling a Molecular-Level Condition for Magnetoreception	12
Unraveling the Photoactivation Mechanism of a Light-Activated Adenylyl Cyclase Using Ultrafast Spectroscopy Coupled with Unnatural Amino Acid Mutagenesis	12
Extrapolating Lessons from Targeted Protein Degradation to Other Proximity-Inducing Drugs	12
HSP27 Inhibitory Activity against Caspase-3 Cleavage and Activation by Caspase-9 Is Enhanced by Chaperone O-GlcNAc Modification in Vitro	12
Targeted Degradation of mRNA Decapping Enzyme DcpS by a VHL-Recruiting PROTAC	12
Chemoenzymatic Synthesis of Novel Cytotoxic Epoxyketones Using the Eponemycin Biosynthetic Enzyme EpnF	12
Synthesis of Differentially Halogenated Lissoclimide Analogues To Probe Ribosome E-Site Binding	12
Membrane Vesicle-Mediated Delivery of Antibacterial Lipopeptides by Pseudoalteromonas piscicida	12
Virus Propagation Linked to Exceedingly Rare Gene-Expression Errors: A Single-Molecule Microscopy Demonstration	12
Identification of DDX5 as a Potential Therapeutic Target of Osteosarcoma Using Thiazolone Probes	12
Metabolic Tracing of Methyl Donor Utilization in Histone Methylation via Relative Quantification of Isotopomer Distribution Mass Spectrometry	12
Origin of the Different Binding Affinities of (9R)- and (9S)-Hexahydrocannabinol (HHC) for the CB₁ and CB₂ Cannabinoid Receptors	12
High-Resolution Substrate Specificity Profiling of SARS-CoV-2 M^pro; Comparison to SARS-CoV M^pro	12
Sustainable B₁₂-Dependent Dehalogenation of Organohalides in E. coli	12
Resolution of the ABA Biosynthesis Controversy: Discovery of a Dihydroxylating Terpene Synthase and Its Convergent Evolution	12
Structure and Biosynthesis of Hectoramide B, a Linear Depsipeptide from Marine Cyanobacterium Moorena producens JHB Discovered via Coculture with Candida albicans	12
Consequences of Peptide Macrocyclization Revealed by Virus-Inspired β-Hairpin Mimetics	12
Forward Genetic Screens Identify Mechanisms of Resistance to Small-Molecule Lactate Dehydrogenase Inhibitors	12
Time-Dependent Studies of Oxaliplatin and Other Nucleolar Stress-Inducing Pt(II) Derivatives	12
Issue Publication Information	12
Issue Publication Information	12
Bacillus spp. Antibacterial Activity Induced by Triphenyl Tetrazolium Chloride against Ralstonia solanacearum: Oxidative Stress Response and Metabolome Changes	12
Select Azo Compounds Post-translationally Modulate HTRA1 Abundance and Activity Potentially through Interactions at the Trimer Interface	12
Identification, Heterologous Expression, and Characterization of the Tolypodiol Biosynthetic Gene Cluster through an Integrated Approach	12
Mechanistic Insights into Harmine-Mediated Inhibition of Human DNA Methyltransferases and Prostate Cancer Cell Growth	12
A C-Degron Structure-Based Approach for the Development of Ligands Targeting the E3 Ligase TRIM7	12
Cyclic γ-AApeptide-Based Molecular Glues for RNA m ⁶ A Editing	12
Site-Specific Photo-Cross-Linking Reveals CCT2 as a Regulator of cGAS-STING Signaling via Clearance of cGAS-DNA Condensates	12
Systematic Study of the Impact of DNA Interstrand Cross-Links on Nucleosome Structure, Sliding, and Transcription	12
Identification of a Selective Pharmacologic IRE1/XBP1s Activator with Enhanced Tissue Exposure	12
Small-Molecule Covalent Stabilization and Inhibition of the TEAD·YAP1 Transcription Factor in Cancer Cells	12
Dynamic Pathway of Guanidine-III Riboswitch Folding Revealed by Single-Molecule FRET: Mg ²⁺ -Assisted Preorganization and Ligand-Induced Kinetic Trap	12
Issue Editorial Masthead	12
A “Goldilocks Zone” for Recruiting BET Proteins with Bromodomain-1-Selective Ligands	11
Chemoproteomics Reveals Disruption of Metal Homeostasis and Metalloproteins by the Antibiotic Holomycin	11
Targeted O-GlcNAcylation of CK2α Triggers Its Ubiquitin-Proteasome Degradation and Alters Downstream Phosphorylation	11
De Novo Synthesis and Structural Elucidation of CDR-H3 Loop Mimics	11
Phospholipids Differentially Regulate Ca²⁺ Binding to Synaptotagmin-1	11
Functional Conservation and Divergence of AlpJ-Family Oxygenases Catalyzing C–C Bond Cleavage in Atypical Angucycline Biosynthesis	11
Strategic Acyl Carrier Protein Engineering Enables Functional Type II Polyketide Synthase Reconstitution In Vitro	11
Multiplex, Quantitative, High-Resolution Imaging of Protein:Protein Complexes via Hybridization Chain Reaction	11
Fragment-Based Development of NSP14 Exonuclease Inhibitors Confounded by Batch-to-Batch Variability	11
Analogs of NIH Molecular Probe ML283 Are Potent SARS-CoV-2 Helicase Inhibitors	11
Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target	11
BID-seq: The Quantitative and Base-Resolution Sequencing Method for RNA Pseudouridine	11
Proximity Labeling Reveals Spatial Regulation of the Anaphase-Promoting Complex/Cyclosome by a Microtubule Adaptor	11