OOIR: Observatory of International Research

Papers

(The TQCC of ACS Chemical Biology is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Introducing Our Authors	93
Discovery and Validation of a Novel Class of Necroptosis Inhibitors Targeting RIPK1	77
Multi-TACs: Targeting Solid Tumors with Multiple Immune Cell Co-engagers	59
Correction to “Characterization of the Iron–Sulfur Cluster in the NCOA4 Fragment (383–522) and Its Interaction with Ferritin”	56
Issue Publication Information	55
Issue Editorial Masthead	53
Biosynthesis of Physcion and Identification of an O-Methyltransferase with C6–OH Selectivity in Aspergillus chevalieri BYST01	52
In Situ Labeling of Pathogenic Tau Using Photo-Affinity Chemical Probes	52
Enzymatic Pathway for Kupyaphore Degradation in Mycobacterium tuberculosis: Mechanism of Metal Homeostasis and Turnover	49
Molecular Targeted Engagement of DPP9 in Rat Tissue Using CETSA, SP3 Processing, and Absolute Quantitation Mass Spectrometry	45
Chemical Synthetic Lethality Screens Identify Selective Drug Combinations against Pseudomonas aeruginosa	44
Dynamic Regulation of 5-Formylcytidine on tRNA	42
A Robust α-l-Fucosidase from Prevotella nigrescens for Glycoengineering Therapeutic Antibodies	41
Li-BrU-seq: A Low-Input and Simplified Metabolic Labeling Method for Nascent RNA Sequencing	40
Ferroptosis Inhibitors Suppress Prostaglandin Synthesis in Lipopolysaccharide-Stimulated Macrophages	39
Reengineering of Circularly Permuted Caspase-2 to Enhance Enzyme Stability and Enable Crystallographic Studies	38
Self-Avoiding Gamma Peptide Nucleic Acids for Selective Targeting of RNA Secondary Structures	37
HiBiT-SpyTag: A Minimal Tag for Covalent Protein Capture and Degrader Development	37
Robust Chemoenzymatic Synthesis of Keratinimicin Aglycone Analogues Facilitated by the Structure and Selectivity of OxyB	35
Mechanistic Studies on Dehydration in Class V Lanthipeptides	35
Simple Enzymatic Incorporation of 2′OMeU Nucleotide at the End of the Poly-A Tail for Enhancement of the mRNA Stability and Protein Expression	33
Enzymatic Macrolactamization of mRNA Display Libraries for Inhibitor Selection	33
Antimicrobial Lasso Peptide Cloacaenodin Utilizes a Unique TonB-Dependent Transporter to Access Susceptible Bacteria	33
Repurposing of the RIPK1-Selective Benzo[1,4]oxazepin-4-one Scaffold for the Development of a Type III LIMK1/2 Inhibitor	33
Structural and Biochemical Insights into Lignin-Oxidizing Activity of Bacterial Peroxidases against Soluble Substrates and Kraft Lignin	33

A RaPID Macrocyclic Peptide Inhibitor of ROR1/2 Strongly Reduces Proliferation of Diffuse Intrinsic Pontine Glioma Cells	32
An Inherent Difference between Serine and Threonine Phosphorylation: Phosphothreonine Strongly Prefers a Highly Ordered, Compact, Cyclic Conformation	31
Target-Responsive DNA Hydrogels with Encapsulation and Release Properties Using Programmable CRISPR-Cas12a	30
Development of Next-Generation Fluoroacetamidine-Containing Activity-Based Probes for the Selective Labeling of the Protein Arginine Deiminases (PADs)	29
Covalent Catalytic Strategies for Enzymes That Modify RNA Molecules on their Tripartite Building Blocks	28
Exploring Metalloproteome Remodeling in Calprotectin-Stressed Acinetobacter baumannii Using Chemoproteomics	28
Sec Signal Peptide Doubles Up as a Leader Sequence in Bufferin Biosynthesis	28
Sulfonadyn Compounds: A Class of Aryl Sulfonamides That Inhibit Dynamin GTPase and Clathrin-Mediated Endocytosis and Are Antiepileptic in Animal Models	28
Christopher T. Walsh: A Prolific Scientist, Effective Academic Leader, and Responsive Mentor	28
Cell-Impermeable Hsp90α-Selective Inhibitor NDNA4 Inhibits Cancer Cell Migration and Targets Extracellular Hsp90α’s Critical F-5 Fragment	28
Issue Publication Information	27
Laboratory Evolution of Metalloid Reductase Substrate Recognition and Nanoparticle Product Size	27
Issue Editorial Masthead	27
Labeling of CC Chemokine Receptor 2 with a Versatile Intracellular Allosteric Probe	27
Issue Publication Information	27
Issue Editorial Masthead	27
Chemical Genetics in C. elegans Identifies Anticancer Mycotoxins Chaetocin and Chetomin as Potent Inducers of a Nuclear Metal Homeostasis Response	26
Analysis of the Valgamicin Biosynthetic Pathway Reveals a General Mechanism for Cyclopropanol Formation across Diverse Natural Product Scaffolds	26
Engineering a Low-Immunogenic Mirror-Image VHH against Vascular Endothelial Growth Factor	26
Clotrimazole-Based Modulators of the TRPM3 Ion Channel Reveal Narrow Structure–Activity Relationship	26
An RNA Methylation-Sensitive AIEgen-Aptamer Reporting System for Quantitatively Evaluating m⁶A Methylase and Demethylase Activities	26
Small-Molecule FICD Inhibitors Suppress Endogenous and Pathologic FICD-Mediated Protein AMPylation	26
Light-Inducible Activation of TrkA for Probing Chronic Pain in Mice	25
ATP Regeneration by Polyphosphate Kinase Powers Efficient Oligosaccharide Synthesis Catalyzed by Glycoside Phosphorylases	25
Phage Display Selection against a Mixture of Protein Targets	25
Chemical Probes that Target a Dissociative LuxR-Type Quorum Sensing Receptor in Gram-Negative Bacteria	25
Design of Class I/IV Bromodomain-Targeting Degraders for Chromatin Remodeling Complexes	25
Targeted Discovery of Cryptic Enediyne Natural Products via FRET-Coupled High-Throughput Elicitor Screening	24
Photoactivatable Plant Hormone-Based Chemical Inducers of Proximity for In Vivo Applications	24
Structure–Activity Relationships of Anabaenopeptins as Carboxypeptidase and Phosphatase Inhibitors	24
Lanmodulin’s EF 2–3 Domain: Insights from Infrared Spectroscopy and Simulations	23
Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization	23
NanoBRET Saturation Analysis with a Novel HaloTag Ligand Reveals Butyrophilin Heteromeric Interactions Controlling γ9δ2 T Cell Activation	23
2-Cyanopyrimidine-Containing Molecules for N-Terminal Selective Cyclization of Phage-Displayed Peptides	23
Inhibitors of the PqsR Quorum-Sensing Receptor Reveal Differential Roles for PqsE and RhlI in Control of Phenazine Production	23
Capture-SELEX-Derived Low-Nanomolar-Affinity Aptamers for Doxorubicin and Inhibition of Cellular Uptake	23
MYC-Targeting PROTACs Lead to Bimodal Degradation and N-Terminal Truncation	23
Bioproduction of a Large-Scale Library of Tryptamine Derivatives for Neuropsychiatric Drug Screening	22
Exploring Protein S-Palmitoylation: Mechanisms, Detection, and Strategies for Inhibitor Discovery	22
Drug-Like Small Molecules That Inhibit Expression of the Oncogenic MicroRNA-21	22
What Is the Crystallographic Resolution of Structural Models of Proteins Generated with AlphaFold2?	22
Genome Mining of Sphingopyxis sp. MG Uncovers an Enzyme with Dual Catalytic Activity of Haloalkane Dehalogenase and Epoxide Hydrolase	22
Issue Editorial Masthead	22
In Silico Discovery of Group II Intron RNA Splicing Inhibitors	21
Taxodione Inhibits Glioblastoma Proliferation and Potentiates the Cytotoxicity of Paclitaxel	21
Native Aminoacyl-tRNA Synthetase/tRNA Pair Drives Highly Efficient Noncanonical Amino Acid Incorporation in Escherichia coli	21
Biosynthesis of the Azoxy Compound Azodyrecin from Streptomyces mirabilis P8-A2	21
Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective Modulators	21
Synthesis and Properties of RNA Modified with Cationic Amine Internucleoside Linkage	21
Evaluation of Thiosaccharides as Carbohydrate-Based Slow-Releasing Hydrogen Sulfide Donors	21

Enzymatic Bromination of Native Peptides for Late-Stage Structural Diversification via Suzuki–Miyaura Coupling	20
SETDB1 Triple Tudor Domain Ligand, ( R , R )-59, Promotes Methylation of Akt1 in Cells	20
Identification of Rapaglutin E as an Isoform-Specific Inhibitor of Glucose Transporter 1	20
Bifunctional Sesquiterpene/Diterpene Synthase Agr2 from Cyclocybe aegerita Gives Rise to the Novel Diterpene Cyclocybene	20
Insights into Substrate Recognition by the Unusual Nitrating Enzyme RufO	20
Beyond KRAS(G12C): Biochemical and Computational Characterization of Sotorasib and Adagrasib Binding Specificity and the Critical Role of H95 and Y96	20
Genome-Guided Discovery of the Myxobacterial Thiolactone-Containing Sorangibactins	20
Structures of Methanomethylophilus alvus Pyrrolysine tRNA-Synthetases Support the Need for De Novo Selections When Altering the Substrate Specificity	20
Dynamic S -Acylation of GSDMA Regulates Pyroptosis	20
A Multi-Split-and-Mix Platform for a Variety of Targeted Protein Degradation	20
Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5	20
Evaluating Linker Architecture in RNA-Detecting Riboglow Probes and Effects on Fluorescence Turn-On	20
Tryptamine Metabolism and Functionalization in Gut Commensal Bacteria Expand Human Tryptamine Signaling Responses	20
A Plastic Biosynthetic Pathway for the Production of Structurally Distinct Microbial Sunscreens	19
Craspase Protease Activation Is Sensitive to Oncogenic Single-Nucleotide RNA Mismatches	19
A Novel Lysosome Targeting Chimera for Targeted Protein Degradation via Split-and-Mix Strategy	19
Chemical Approaches To Investigate Post-transcriptional RNA Regulation	19
Widespread, Reversible Cysteine Modification by Methylglyoxal Regulates Metabolic Enzyme Function	19
Pre-miR-21 Conformational Equilibrium Modulates the Efficacy of the Maturation Inhibitor L50	19
Fitness Landscape-Guided Engineering of Locally Supercharged Virus-like Particles with Enhanced Cell Uptake Properties	19
PPARγ Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles	19
Optimizing Peptide-Conjugated Lipid Nanoparticles for Efficient siRNA Delivery across the Blood–Brain Barrier and Treatment of Glioblastoma Multiforme	19
Comparative Analysis of Drug-like EP300/CREBBP Acetyltransferase Inhibitors	19
Photocaged Chloroquine Derivatives for the Light-Dependent Inhibition of Autophagy in Cancer Stem Cells	19
Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct	18
Issue Editorial Masthead	18
G Protein-Biased Agonists for Intracellular Angiotensin Receptors Promote Collagen Secretion in Myofibroblasts	18
Insights into Free Drug Release from Efficacious N-Acyl O-Aminophenol Duocarmycin Prodrugs	18
Issue Publication Information	18
In Vivo Metabolic Labeling with an Isoprenoid Probe Reveals APOE Allele-Specific Differences in the Prenylome	18
Correction to “Analysis of the Sequence Preference of Saporin by Deep Sequencing”	18
Multimodal Blood-Based Biomarker Panel Reveals Altered Lysosomal Ionic Content in Alzheimer’s Disease	18
Issue Editorial Masthead	18
Biphasic Cellular Response Triggered by Tetrandrine-Mediated Dysfunction and Lysophagic Clearance of Lysosomes	17
Characterization of Chemical Interactions between Clinical Drugs and the Oral Bacterium, Corynebacterium matruchotii, via Bioactivity-HiTES	17
Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity	17
Chemoproteomic Profiling Reveals the Mechanism of Bile Acid Tolerance in Bacteria	17
Metabolic Glycan Labeling in Primary Neurons Enabled by Unnatural Sugars with No S-Glyco-Modification	17
Discovery of Small-Molecule Inhibitors of the Pycsar Antiphage Defense	17
Genome Mining of Myxopeptins Reveals a Class of Lanthipeptide-Derived Linear Dehydroamino Acid-Containing Peptides from Myxococcus sp. MCy9171	17
Chemoenzymatic Probes Reveal Peptidoglycan Recognition and Uptake Mechanisms in Candida albicans	17
The Relationship between Substrate Structure and Selectivity of Ketoreduction in Multimodular Polyketide Synthases: A Comparative Study of A-Type Ketoreductases from Late Modules Using Complex Precurs	17
Mapping snoRNA Targets Transcriptome-Wide with snoKARR-seq	17
Structural, Biochemical, and Bioinformatic Basis for Identifying Radical SAM Cyclopropyl Synthases	17
Natural Product-Derived Ianthelliformisamines Inhibit Protein Translation and Block Bacterial Flagellum Assembly	16
Discovery of a Compound That Inhibits IRE1α S-Nitrosylation and Preserves the Endoplasmic Reticulum Stress Response under Nitrosative Stress	16
Authentic Phosphorylation of α-Synuclein at Ser129 Reveals Functional Differences Not Captured by the S129D Phosphomimetic	16
Development of Comprehensive Screening and Assessment Assays for Small-Molecule Ligands of MALAT1 lncRNA	16
Correction to “A cAMP Sensor Based on Ligand-Dependent Protein Stabilization”	16
Chemical Probe Approach Reveals Endo-α-mannosidase Triages Misfolded Glycoproteins in the Calnexin/Calreticulin Cycle	16
Pathogenic SNPs Affect Both RNA and DNA G-Quadruplexes’ Responses to Ligands	16
Stable Isotope-Guided Metabolomics Reveals Polar-Functionalized Fatty-Acylated RiPPs from Streptomyces	16
Multivalent Peptide-DNA Conjugates Facilitate DNA Internalization in Cells Expressing Glycosaminoglycans	16
Adenylation Domain-Guided Recruitment of Trans-Acting Nonheme Monooxygenases in Nonribosomal Peptide Biosynthesis	16
Site-Specific Introduction of Alanines for the Nuclear Magnetic Resonance Investigation of Low-Complexity Regions and Large Biomolecular Assemblies	16
Phage Selection of Cyclic Peptides Inhibiting Aminoglycoside Phosphotransferases to Control Resistant Bacteria	16
Advances in Optogenetics and Thermogenetics for Control of Non-Neuronal Cells and Tissues in Biomedical Research	16
Screen for Modulation of Nucleocapsid Protein Condensation Identifies Small Molecules with Anti-Coronavirus Activity	16
Issue Publication Information	16
Orthogonal Conjugation via Endoglycosidase and Microbial Transglutaminase Enables Efficient Synthesis of Dual-Payload Antibody-Drug Conjugates	16
A Fluorescence Polarization Assay for Macrodomains Facilitates the Identification of Potent Inhibitors of the SARS-CoV-2 Macrodomain	15
Discovery and Mechanism of 16–19F, a Novel Synthetic Lethal Inhibitor of the PRMT5•MTA Complex in MTAP-Deleted Cancer Cells	15
CRISPR RiPCA for Investigating eIF4E-m⁷GpppX Capped mRNA Interactions	15
Protein-Labeling Reagents Selectively Activated by Copper(I)	15
Introducing Our Authors	15
Mechanistic Analysis of Bioorthogonal Double Strain-Promoted Alkyne–Nitrone Cycloadditions Involving Dibenzocyclooctadiyne	15
Fungal NRPS-PKS Hybrid Enzymes Biosynthesize New γ-Lactam Compounds, Taslactams A-D, Analogous to Actinomycete Proteasome Inhibitors	15
Neurotoxic Implications of Human Coronaviruses in Neurodegenerative Diseases: A Perspective from Amyloid Aggregation	15
Targeted Protein Degradation through Recruitment of the CUL4 Complex Adaptor Protein DDB1	15
Reversible Antagonism of Dopamine D1 Receptor Using a Photoswitchable Remotely Tethered Ligand	15
High-Throughput Activity Reprogramming of Proteases (HARP)	15
Uncovering the Association Mechanism between Two Intrinsically Flexible Proteins	15
Visualizing Intracellular Localization of Natural-Product-Based Chemical Probes Using Click-Correlative Light and Electron Microscopy	15
Elucidating the Ferroptotic Black Box: Radical-Trapping Antioxidant Probes Illuminate Subcellular Onset and Progression	15
Engineering H₂S-Activatable Aptameric Binders for Tailored Cell Manipulation	15
Real-Time Cellular Thermal Shift Assay to Monitor Target Engagement	15
New High-Throughput Screen Discovers Novel Ligands of Full-Length Nuclear Receptor LRH-1	15
Enhancing the Anticancer Activity of Attenuated Listeria monocytogenes by Cell Wall Functionalization with “Clickable” Doxorubicin	15
Modulation of Core-Fucosylation Oxidation for Selective Enrichment and Characterization of Cell Surface Glycoprotein	15
Dual-Probe Activity-Based Protein Profiling Reveals Site-Specific Differences in Protein Binding of EGFR-Directed Drugs	15

Omniligase-1-Mediated Phage-Peptide Library Modification and Insulin Engineering	15
The Impact of Sugar Conformation on the Single-Stranded DNA Selectivity of APOBEC3A and APOBEC3B Enzymes	15
Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an S_Ni Mechanism and Ion Pair Transition State	15
Elucidating the Role of the Competence Regulon Quorum Sensing Circuitry in Streptococcus cristatus	14
The Endoplasmic Reticulum-Located TRPV1 Channel Is Not Thermal Sensitive	14
4″-Methyl- S -Adenosyl- l -Methionines Are Substrates for 4-Methylazetidinecarboxylic Acid Synthases	14
Issue Publication Information	14
microRNAs Regulate Cellular Magnesium by Tuning Expression of the Plasma Membrane Protein CNNM4	14
Selective Targeting of Protein Arginine Methyltransferase 1 (PRMT1) Mutant Activity by a Small Molecule Activation Strategy	14
Structural Insights into Spare-Tire DNA G-Quadruplex from the Human VEGF Promoter	14
Design, Synthesis, and Mechanistic Studies of (R)-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase	14
Issue Editorial Masthead	14
Decoding Protein–Peptide Interactions Using a Large, Target-Agnostic Yeast Surface Display Library	14
A Bispecific Antibody Engineering Strategy for Effective Dual-Target Degradation of Cell-Surface and Secreted Oncoproteins with Superior Antitumor Activity	14
A Tandem-Affinity Purification Method for Identification of Primary Intracellular Drug-Binding Proteins	14
Leveraging Covalency to Stabilize Ternary Complex Formation For Cell–Cell “Induced Proximity”	14
Switching Prenyl Donor Specificities in Squalene Synthase-Like Aromatic Prenyltransferases from Bacterial Carbazole Alkaloid Biosynthesis	14
Borinic Acid-Based Fluorogenic Probes as an Alternative to the Amplex Red Assay for Real-Time H₂O₂ Monitoring in Live Cells	14
Structural Insights and Reaction Profile of a New Unspecific Peroxygenase from Marasmius wettsteinii Produced in a Tandem-Yeast Expression System	14
Studies Pertaining to the Emerging Cannabinoid Hexahydrocannabinol (HHC)	14
Class IIb Microcin MccM Interferes with Oxidative Phosphorylation in Escherichia coli	14
Manipulation of Global Regulator mcrA Activates the Fumigermin Pathway in Penicillium camemberti IMV00769	14
A Scavenger Hunt for a DyP-Peroxidase from a Metagenome: Curated Peroxidase Database-Assisted Primer Design and Protein Structure Elucidation	14
Discovery of Cyclic Lipopeptides Ralstopeptins A and B from Ralstonia solanacearum Species Complex and Analysis of Biosynthetic Gene Evolution	14
Introducing Our Authors	14
A Repurposed Drug Interferes with Nucleic Acid to Inhibit the Dual Activities of Coronavirus Nsp13	14
Novel Substrate Prediction for the TAM Family of RTKs Using Phosphoproteomics and Structure-Based Modeling	13
Development of a New DHFR-Based Destabilizing Domain with Enhanced Basal Turnover and Applicability in Mammalian Systems	13
Introducing Our Authors	13
Unraveling the Photoactivation Mechanism of a Light-Activated Adenylyl Cyclase Using Ultrafast Spectroscopy Coupled with Unnatural Amino Acid Mutagenesis	13
Issue Publication Information	13
Bacillus spp. Antibacterial Activity Induced by Triphenyl Tetrazolium Chloride against Ralstonia solanacearum: Oxidative Stress Response and Metabolome Changes	13
Metabolic Investigation and Auxiliary Enzyme Modelization of the Pyrrocidine Pathway Allow Rationalization of Paracyclophane-Decahydrofluorene Formation	13
Acarbose May Function as a Competitive Exclusion Agent for the Producing Bacteria	13
Cooperative Membrane Damage as a Mechanism for Pentamidine–Antibiotic Mutual Sensitization	13
Biosynthesis of Bacillus Phosphonoalamides Reveals Highly Specific Amino Acid Ligation	13
Rapid Evaluation of Staple Placement in Stabilized α Helices Using Bacterial Surface Display	13
Controlling Tricyclic Peptide Architecture in mRNA Display through Orthogonal Reactivity on Rotationally Flexible Scaffolds	13
Phage Display of Two Distinct Warheads to Inhibit Challenging Proteins	13
Metabolic Tracing of Methyl Donor Utilization in Histone Methylation via Relative Quantification of Isotopomer Distribution Mass Spectrometry	13
Extrapolating Lessons from Targeted Protein Degradation to Other Proximity-Inducing Drugs	13
Consequences of Peptide Macrocyclization Revealed by Virus-Inspired β-Hairpin Mimetics	13
Donor-PeT Control of Intersystem Crossing Enables ALDH1A1-Activated Photodynamic Therapy	13
Issue Editorial Masthead	13
Regulatory and Catalytic Domains of Poly(ADP-ribose) Polymerases Cross-Complement for DNA-Break-Dependent Allosteric Stimulation of Catalytic Activity	13
General Approach to Identify, Assess, and Characterize Inhibitors of Lipid Peroxidation and Associated Cell Death	13
Kinetic and Thermodynamic Insights into Agonist Interactions with the Parathyroid Hormone Receptor-1 from a New NanoBRET Assay	13
Selection of Optimal Cell Lines for High-Content Phenotypic Screening	13
Machine Learning Uncovers Natural Product Modulators of the 5-Lipoxygenase Pathway and Facilitates the Elucidation of Their Biological Mechanisms	13
Localized Light-Triggered CO Delivery: Comparing the Amount of CO Delivered and Cellular Toxicity	13
Origin of the Different Binding Affinities of (9R)- and (9S)-Hexahydrocannabinol (HHC) for the CB₁ and CB₂ Cannabinoid Receptors	13
Cyclic γ-AApeptide-Based Molecular Glues for RNA m ⁶ A Editing	13
Issue Publication Information	13
Synthesis of Differentially Halogenated Lissoclimide Analogues To Probe Ribosome E-Site Binding	13
Cytochrome P450 Mining for Bufadienolide Diversification	13
MicroED as a Powerful Tool for Structure Determination of Macrocyclic Drug Compounds Directly from Their Powder Formulations	13
fpocketR : A Platform for Identification and Analysis of Ligand-Binding Pockets in RNA	13
DNA-Encoded Library Technology─A Catalyst for Covalent Ligand Discovery	13
Site-Specific Photo-Cross-Linking Reveals CCT2 as a Regulator of cGAS-STING Signaling via Clearance of cGAS-DNA Condensates	12
Membrane Vesicle-Mediated Delivery of Antibacterial Lipopeptides by Pseudoalteromonas piscicida	12
A C-Degron Structure-Based Approach for the Development of Ligands Targeting the E3 Ligase TRIM7	12
Structure and Biosynthesis of Hectoramide B, a Linear Depsipeptide from Marine Cyanobacterium Moorena producens JHB Discovered via Coculture with Candida albicans	12
Time-Dependent Studies of Oxaliplatin and Other Nucleolar Stress-Inducing Pt(II) Derivatives	12
HSP27 Inhibitory Activity against Caspase-3 Cleavage and Activation by Caspase-9 Is Enhanced by Chaperone O-GlcNAc Modification in Vitro	12
High-Throughput Profiling of Prenylelongases Enables the Assembly of Modified Prenoids	12
Introducing Our Authors	12
Engineered Glycan-Binding Proteins for Recognition of the Thomsen–Friedenreich Antigen and Structurally Related Disaccharides	12
Select Azo Compounds Post-translationally Modulate HTRA1 Abundance and Activity Potentially through Interactions at the Trimer Interface	12
Dynamic Pathway of Guanidine-III Riboswitch Folding Revealed by Single-Molecule FRET: Mg ²⁺ -Assisted Preorganization and Ligand-Induced Kinetic Trap	12
Identification, Heterologous Expression, and Characterization of the Tolypodiol Biosynthetic Gene Cluster through an Integrated Approach	12
Stability-Based Proteomic Methods Add Value to Activity-Based Protein Profiling Studies	12
Identification of DDX5 as a Potential Therapeutic Target of Osteosarcoma Using Thiazolone Probes	12
Chemoenzymatic Synthesis of Novel Cytotoxic Epoxyketones Using the Eponemycin Biosynthetic Enzyme EpnF	12
Resolution of the ABA Biosynthesis Controversy: Discovery of a Dihydroxylating Terpene Synthase and Its Convergent Evolution	12
Systematic Study of the Impact of DNA Interstrand Cross-Links on Nucleosome Structure, Sliding, and Transcription	12
Small-Molecule Covalent Stabilization and Inhibition of the TEAD·YAP1 Transcription Factor in Cancer Cells	12
Forward Genetic Screens Identify Mechanisms of Resistance to Small-Molecule Lactate Dehydrogenase Inhibitors	12
Alkyne Tags for Multiplexed, Optical Photothermal Infrared Imaging of Cellular Metabolites	12
Mechanistic Insights into Harmine-Mediated Inhibition of Human DNA Methyltransferases and Prostate Cancer Cell Growth	12
Generating Efficient Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetases for Structurally Diverse Non-Canonical Amino Acids	12
Sustainable B₁₂-Dependent Dehalogenation of Organohalides in E. coli	12
High-Resolution Substrate Specificity Profiling of SARS-CoV-2 M^pro; Comparison to SARS-CoV M^pro	11
Proximity Labeling Reveals Spatial Regulation of the Anaphase-Promoting Complex/Cyclosome by a Microtubule Adaptor	11
Engineered Branaplam Aptamers Exploit Structural Elements from Natural Riboswitches	11
Analogs of NIH Molecular Probe ML283 Are Potent SARS-CoV-2 Helicase Inhibitors	11
BID-seq: The Quantitative and Base-Resolution Sequencing Method for RNA Pseudouridine	11
Identification of a Selective Pharmacologic IRE1/XBP1s Activator with Enhanced Tissue Exposure	11
Incorporation of Aliphatic Proline Residues into Recombinantly Produced Insulin	11
De Novo Synthesis and Structural Elucidation of CDR-H3 Loop Mimics	11
Characterization of RufT Thioesterase Domain Reveals Insights into Rufomycin Cyclization and the Biosynthetic Origin of Rufomyazine	11
Issue Publication Information	11
Ambigols Uncouple Oxidative Phosphorylation In Vitro	11
Conformational Frustration at the Protein–Glycan Interface of a Nonmitogenic Anti-HIV Lectin Results in Altered Quaternary Structure	11
Thymidine Kinase-Independent Click Chemistry DNADetect Probes for DNA Proliferation Assessment in Malaria Parasites	11
Escherichia coli yybP-ykoY Riboswitch as a Tandem Riboswitch Regulated by Mn²⁺ and pH	11