OOIR: Observatory of International Research

Papers

(The TQCC of ACS Chemical Biology is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Issue Publication Information	203
Simple Enzymatic Incorporation of 2′OMeU Nucleotide at the End of the Poly-A Tail for Enhancement of the mRNA Stability and Protein Expression	97
Introducing Our Authors	96
Deposition Bias of Chromatin Proteins Inverts under DNA Replication Stress Conditions	83
Introducing Our Authors	76
A Robust α-l-Fucosidase from Prevotella nigrescens for Glycoengineering Therapeutic Antibodies	73
HiBiT-SpyTag: A Minimal Tag for Covalent Protein Capture and Degrader Development	70
Issue Editorial Masthead	61
Molecular Targeted Engagement of DPP9 in Rat Tissue Using CETSA, SP3 Processing, and Absolute Quantitation Mass Spectrometry	59
Structure and Function of the β-Asp-Arg Polymerase Cyanophycin Synthetase 2	57
Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism	54
Visualization of Ectopic Serine Protease Activity by Förster Resonance Energy Transfer-Based Reporters	51
A Nonfunctional Halogenase Masquerades as an Aromatizing Dehydratase in Biosynthesis of Pyrrolic Polyketides by Type I Polyketide Synthases	50
Multi-TACs: Targeting Solid Tumors with Multiple Immune Cell Co-engagers	49
In Situ Labeling of Pathogenic Tau Using Photo-Affinity Chemical Probes	49
Spontaneous Cleavage at Glu and Gln Residues in Long-Lived Proteins	48
Robust Chemoenzymatic Synthesis of Keratinimicin Aglycone Analogues Facilitated by the Structure and Selectivity of OxyB	45
Repurposing of the RIPK1-Selective Benzo[1,4]oxazepin-4-one Scaffold for the Development of a Type III LIMK1/2 Inhibitor	44
Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer	44
Chemical Synthetic Lethality Screens Identify Selective Drug Combinations against Pseudomonas aeruginosa	43
Biosynthesis of Physcion and Identification of an O-Methyltransferase with C6–OH Selectivity in Aspergillus chevalieri BYST01	41
Dynamic Regulation of 5-Formylcytidine on tRNA	41
Structural and Biochemical Insights into Lignin-Oxidizing Activity of Bacterial Peroxidases against Soluble Substrates and Kraft Lignin	41
Reengineering of Circularly Permuted Caspase-2 to Enhance Enzyme Stability and Enable Crystallographic Studies	40
Ferroptosis Inhibitors Suppress Prostaglandin Synthesis in Lipopolysaccharide-Stimulated Macrophages	39

Targeting IRAK3 for Degradation to Enhance IL-12 Pro-inflammatory Cytokine Production	39
Antimicrobial Lasso Peptide Cloacaenodin Utilizes a Unique TonB-Dependent Transporter to Access Susceptible Bacteria	39
Mechanistic Studies on Dehydration in Class V Lanthipeptides	38
Enzymatic Macrolactamization of mRNA Display Libraries for Inhibitor Selection	38
An Inherent Difference between Serine and Threonine Phosphorylation: Phosphothreonine Strongly Prefers a Highly Ordered, Compact, Cyclic Conformation	38
Spatiotemporal Proximity Labeling Tools to Track GlcNAc Sugar-Modified Functional Protein Hubs during Cellular Signaling	38
Issue Editorial Masthead	37
Issue Publication Information	36
ACS Chemical Biology─2022 Editorial Statement	36
Issue Publication Information	36
Christopher T. Walsh: A Prolific Scientist, Effective Academic Leader, and Responsive Mentor	36
Analysis of the Valgamicin Biosynthetic Pathway Reveals a General Mechanism for Cyclopropanol Formation across Diverse Natural Product Scaffolds	35
2-Cyanopyrimidine-Containing Molecules for N-Terminal Selective Cyclization of Phage-Displayed Peptides	34
Design of Class I/IV Bromodomain-Targeting Degraders for Chromatin Remodeling Complexes	34
Targeted Discovery of Cryptic Enediyne Natural Products via FRET-Coupled High-Throughput Elicitor Screening	34
Lanmodulin’s EF 2–3 Domain: Insights from Infrared Spectroscopy and Simulations	33
Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization	33
MYC-Targeting PROTACs Lead to Bimodal Degradation and N-Terminal Truncation	33
Small-Molecule FICD Inhibitors Suppress Endogenous and Pathologic FICD-Mediated Protein AMPylation	32
C₃-Symmetric Aromatic Core of Griffithsin Is Essential for Potent Anti-HIV Activity	31
High-Speed Diagnosis of Bacterial Pathogens at the Single Cell Level by Raman Microspectroscopy with Machine Learning Filters and Denoising Autoencoders	31
Mycobacterium tuberculosis PanD Structure–Function Analysis and Identification of a Potent Pyrazinoic Acid-Derived Enzyme Inhibitor	31
Split–Combine Click-SELEX Reveals Ligands Recognizing the Transplant Rejection Biomarker CXCL9	30
Region-Specific and Age-Dependent Multitarget Effects of Acetylcholinesterase Inhibitor Tacrine on Comprehensive Neurotransmitter Systems	30
Covalent Catalytic Strategies for Enzymes That Modify RNA Molecules on their Tripartite Building Blocks	29
An RNA Methylation-Sensitive AIEgen-Aptamer Reporting System for Quantitatively Evaluating m⁶A Methylase and Demethylase Activities	27
Laboratory Evolution of Metalloid Reductase Substrate Recognition and Nanoparticle Product Size	27
Chemical Genetics in C. elegans Identifies Anticancer Mycotoxins Chaetocin and Chetomin as Potent Inducers of a Nuclear Metal Homeostasis Response	27
Clotrimazole-Based Modulators of the TRPM3 Ion Channel Reveal Narrow Structure–Activity Relationship	27
Issue Editorial Masthead	26
Light-Inducible Activation of TrkA for Probing Chronic Pain in Mice	26
Photoactivatable Plant Hormone-Based Chemical Inducers of Proximity for In Vivo Applications	26
Exploring Protein S-Palmitoylation: Mechanisms, Detection, and Strategies for Inhibitor Discovery	26
Engineering a Low-Immunogenic Mirror-Image VHH against Vascular Endothelial Growth Factor	26
Genome-Guided Discovery of the Myxobacterial Thiolactone-Containing Sorangibactins	25
Beyond KRAS(G12C): Biochemical and Computational Characterization of Sotorasib and Adagrasib Binding Specificity and the Critical Role of H95 and Y96	25
Labeling of CC Chemokine Receptor 2 with a Versatile Intracellular Allosteric Probe	25
Bacterial Toxins Escape the Endosome by Inducing Vesicle Budding and Collapse	25
Widespread, Reversible Cysteine Modification by Methylglyoxal Regulates Metabolic Enzyme Function	25
Repurposing the Damage Repair Protein Methyl Guanine Methyl Transferase as a Ligand Inducible Fusion Degron	25
Insights into Substrate Recognition by the Unusual Nitrating Enzyme RufO	25
A Novel Lysosome Targeting Chimera for Targeted Protein Degradation via Split-and-Mix Strategy	24
Native Aminoacyl-tRNA Synthetase/tRNA Pair Drives Highly Efficient Noncanonical Amino Acid Incorporation in Escherichia coli	24
Identification of Rapaglutin E as an Isoform-Specific Inhibitor of Glucose Transporter 1	24
Optimizing Peptide-Conjugated Lipid Nanoparticles for Efficient siRNA Delivery across the Blood–Brain Barrier and Treatment of Glioblastoma Multiforme	24
A Sort-Seq Approach to the Development of Single Fluorescent Protein Biosensors	23
Bifunctional Sesquiterpene/Diterpene Synthase Agr2 from Cyclocybe aegerita Gives Rise to the Novel Diterpene Cyclocybene	23
Insights into the Polyhydroxybutyrate Biosynthesis in Ralstonia solanacearum Using Parallel ¹³C Tracers and Comparative Genome Analysis	23
What Is the Crystallographic Resolution of Structural Models of Proteins Generated with AlphaFold2?	23
Convergent Alterations of a Protein Hub Produce Divergent Effects within a Binding Site	23

Chemical Therapies for Congenital Disorders of Glycosylation	23
Fitness Landscape-Guided Engineering of Locally Supercharged Virus-like Particles with Enhanced Cell Uptake Properties	22
Structures of Methanomethylophilus alvus Pyrrolysine tRNA-Synthetases Support the Need for De Novo Selections When Altering the Substrate Specificity	22
Biosynthesis of the Azoxy Compound Azodyrecin from Streptomyces mirabilis P8-A2	22
Introducing Our Authors	22
Cyclative Release Strategy to Obtain Pure Cyclic Peptides Directly from the Solid Phase	22
A Plastic Biosynthetic Pathway for the Production of Structurally Distinct Microbial Sunscreens	22
Tetrazine-Ligated CRISPR sgRNAs for Efficient Genome Editing	22
In Silico Discovery of Group II Intron RNA Splicing Inhibitors	22
Analogs of the Dopamine Metabolite 5,6-Dihydroxyindole Bind Directly to and Activate the Nuclear Receptor Nurr1	22
Endogenous ROS-Mediated Covalent Immobilization of Gold Nanoparticles in Mitochondria: A “Sharp Sword” in Tumor Radiotherapy	22
SETDB1 Triple Tudor Domain Ligand, (R,R)-59, Promotes Methylation of Akt1 in Cells	22
Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective Modulators	21
Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5	21
Issue Editorial Masthead	21
Synthesis and Properties of RNA Modified with Cationic Amine Internucleoside Linkage	21
Drug-Like Small Molecules That Inhibit Expression of the Oncogenic MicroRNA-21	21
SARS-CoV-2 RBD-Tetanus Toxoid Conjugate Vaccine Induces a Strong Neutralizing Immunity in Preclinical Studies	21
Issue Editorial Masthead	21
Characterization of Endogenous and Extruded H₂S and Small Oxoacids of Sulfur (SOS) in Cell Cultures	21
Near-Infrared Fluorescent Probes for the Detection of Cancer-Associated Proteases	20
Issue Editorial Masthead	20
O-GlcNAcylation Quantification of Certain Protein by the Proximity Ligation Assay and Clostridium perfringen OGA^D298N(CpOGA^D298N)	20
Correction to “Analysis of the Sequence Preference of Saporin by Deep Sequencing”	20
PPARγ Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles	20
Multiparametric High-Content Cell Painting Identifies Copper Ionophores as Selective Modulators of Esophageal Cancer Phenotypes	20
Discovery of Highly Specific Catalytic-Site-Targeting Fluorescent Probes for Detecting Lysosomal PDE10A in Living Cells	20
Activity-Based Diagnostics: Recent Advances in the Development of Probes for Use with Diverse Detection Modalities	20
Comparative Analysis of Drug-like EP300/CREBBP Acetyltransferase Inhibitors	20
Issue Publication Information	20
Discovery of an Unexpected Similarity in Ligand Binding between BRD4 and PPARγ	20
Targeting Gαi/s Proteins with Peptidyl Nucleotide Exchange Modulators	20
Directed Evolution of PD-L1-Targeted Affibodies by mRNA Display	20
Discovery of a Compound That Inhibits IRE1α S-Nitrosylation and Preserves the Endoplasmic Reticulum Stress Response under Nitrosative Stress	19
Modulation of Specialized Metabolite Production in Genetically Engineered Streptomyces pactum	19
Screen for Modulation of Nucleocapsid Protein Condensation Identifies Small Molecules with Anti-Coronavirus Activity	19
In Situ Assembly of Transmembrane Proteins from Expressed and Synthetic Components in Giant Unilamellar Vesicles	19
Multimodal Blood-Based Biomarker Panel Reveals Altered Lysosomal Ionic Content in Alzheimer’s Disease	19
Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct	19
Site-Specific Introduction of Alanines for the Nuclear Magnetic Resonance Investigation of Low-Complexity Regions and Large Biomolecular Assemblies	19
Identification of Secondary Binding Sites on Protein Surfaces for Rational Elaboration of Synthetic Protein Mimics	19
Characterization of Chemical Interactions between Clinical Drugs and the Oral Bacterium, Corynebacterium matruchotii, via Bioactivity-HiTES	19
Pathogenic SNPs Affect Both RNA and DNA G-Quadruplexes’ Responses to Ligands	19
Genome Mining of Myxopeptins Reveals a Class of Lanthipeptide-Derived Linear Dehydroamino Acid-Containing Peptides from Myxococcus sp. MCy9171	18
Advances in Optogenetics and Thermogenetics for Control of Non-Neuronal Cells and Tissues in Biomedical Research	18
Chemical Approaches To Investigate Post-transcriptional RNA Regulation	18
Structure and Function of a Dual Reductase–Dehydratase Enzyme System Involved in p-Terphenyl Biosynthesis	18
Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions	18
Issue Publication Information	18
Mapping snoRNA Targets Transcriptome-Wide with snoKARR-seq	18
Orthogonal Active-Site Labels for Mixed-Linkage endo-β-Glucanases	18
Functional Characterization of Structural Genomics Proteins in the Crotonase Superfamily	18
G Protein-Biased Agonists for Intracellular Angiotensin Receptors Promote Collagen Secretion in Myofibroblasts	18
The Relationship between Substrate Structure and Selectivity of Ketoreduction in Multimodular Polyketide Synthases: A Comparative Study of A-Type Ketoreductases from Late Modules Using Complex Precurs	18
Insights into Free Drug Release from Efficacious N-Acyl O-Aminophenol Duocarmycin Prodrugs	18
Blinking Fluorescent Probes for Tubulin Nanoscopy in Living and Fixed Cells	18
Selective Transformations of Carbohydrates Inspired by Radical-Based Enzymatic Mechanisms	18
Issue Publication Information	17
Uncovering the Association Mechanism between Two Intrinsically Flexible Proteins	17
Chemoenzymatic Probes Reveal Peptidoglycan Recognition and Uptake Mechanisms in Candida albicans	17
Development of an Acrylamide-Based Inhibitor of Protein S-Acylation	17
Issue Publication Information	17
Decay of Piwi-Interacting RNAs in Human Cells Is Primarily Mediated by 5′ to 3′ Exoribonucleases	17
The Impact of Sugar Conformation on the Single-Stranded DNA Selectivity of APOBEC3A and APOBEC3B Enzymes	17
Correction to “A cAMP Sensor Based on Ligand-Dependent Protein Stabilization”	17
Stable Isotope-Guided Metabolomics Reveals Polar-Functionalized Fatty-Acylated RiPPs from Streptomyces	17
Development of Comprehensive Screening and Assessment Assays for Small-Molecule Ligands of MALAT1 lncRNA	17
Metabolic Glycan Labeling in Primary Neurons Enabled by Unnatural Sugars with No S-Glyco-Modification	17
Issue Publication Information	17
Enhancing the Anticancer Activity of Attenuated Listeria monocytogenes by Cell Wall Functionalization with “Clickable” Doxorubicin	17
Mechanistic Analysis of Bioorthogonal Double Strain-Promoted Alkyne–Nitrone Cycloadditions Involving Dibenzocyclooctadiyne	17
Structural, Biochemical, and Bioinformatic Basis for Identifying Radical SAM Cyclopropyl Synthases	17
Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity	17
Chemoproteomic Profiling Reveals the Mechanism of Bile Acid Tolerance in Bacteria	17
Issue Publication Information	17
Drugging the Sarcomere, a Delicate Balance: Position of N-Terminal Charge of the Inhibitor W7	16
Fluorinated Phosphoadenosine 5′-Phosphosulfate Analogues for Continuous Sulfotransferase Activity Monitoring and Inhibitor Screening by ¹⁹F NMR Spectroscopy	16
The HPK1 Inhibitor A-745 Verifies the Potential of Modulating T Cell Kinase Signaling for Immunotherapy	16
Adenylation Domain-Guided Recruitment of Trans-Acting Nonheme Monooxygenases in Nonribosomal Peptide Biosynthesis	16
Visualizing Intracellular Localization of Natural-Product-Based Chemical Probes Using Click-Correlative Light and Electron Microscopy	16

Design, Synthesis, and Mechanistic Studies of (R)-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase	16
Identification of Chemical Probes Targeting MBD2	16
Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity	16
Writing and Erasing O-GlcNAc on Casein Kinase 2 Alpha Alters the Phosphoproteome	16
Dual-Probe Activity-Based Protein Profiling Reveals Site-Specific Differences in Protein Binding of EGFR-Directed Drugs	16
Protein-Labeling Reagents Selectively Activated by Copper(I)	16
Structural Insights and Reaction Profile of a New Unspecific Peroxygenase from Marasmius wettsteinii Produced in a Tandem-Yeast Expression System	16
New High-Throughput Screen Discovers Novel Ligands of Full-Length Nuclear Receptor LRH-1	16
Neurotoxic Implications of Human Coronaviruses in Neurodegenerative Diseases: A Perspective from Amyloid Aggregation	15
Targeted Protein Degradation through Recruitment of the CUL4 Complex Adaptor Protein DDB1	15
A Repurposed Drug Interferes with Nucleic Acid to Inhibit the Dual Activities of Coronavirus Nsp13	15
Real-Time Cellular Thermal Shift Assay to Monitor Target Engagement	15
Omniligase-1-Mediated Phage-Peptide Library Modification and Insulin Engineering	15
Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the Chemokine Receptor CCR2	15
CH−π Interactions in Glycan Recognition	15
Development and Efficacy of an Orally Bioavailable Selective TAK1 Inhibitor for the Treatment of Inflammatory Arthritis	15
Elucidating the Role of the Competence Regulon Quorum Sensing Circuitry in Streptococcus cristatus	15
A Fluorescence Polarization Assay for Macrodomains Facilitates the Identification of Potent Inhibitors of the SARS-CoV-2 Macrodomain	15
In-Depth Site-Specific O-Glycosylation Analysis of Glycoproteins and Endogenous Peptides in Cerebrospinal Fluid (CSF) from Healthy Individuals, Mild Cognitive Impairment (MCI), and Alzheimer’s Disease	15
Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an S_Ni Mechanism and Ion Pair Transition State	15
Fungal NRPS-PKS Hybrid Enzymes Biosynthesize New γ-Lactam Compounds, Taslactams A-D, Analogous to Actinomycete Proteasome Inhibitors	15
Studies Pertaining to the Emerging Cannabinoid Hexahydrocannabinol (HHC)	15
Development of a Benzothiazole Scaffold-Based Androgen Receptor N-Terminal Inhibitor for Treating Androgen-Responsive Prostate Cancer	15
Identification of NQO2 As a Protein Target in Small Molecule Modulation of Hepatocellular Function	14
Regulatory and Catalytic Domains of Poly(ADP-ribose) Polymerases Cross-Complement for DNA-Break-Dependent Allosteric Stimulation of Catalytic Activity	14
A Capture Strategy for the Identification of Thio-Templated Metabolites	14
Issue Editorial Masthead	14
Development of a New DHFR-Based Destabilizing Domain with Enhanced Basal Turnover and Applicability in Mammalian Systems	14
Novel Substrate Prediction for the TAM Family of RTKs Using Phosphoproteomics and Structure-Based Modeling	14
Leveraging Covalency to Stabilize Ternary Complex Formation For Cell–Cell “Induced Proximity”	14
Inhibition of Mycobacterium tuberculosis Dethiobiotin Synthase (MtDTBS): Toward Next-Generation Antituberculosis Agents	14
Combined Effect of Anti-SSEA4 and Anti-Globo H Antibodies on Breast Cancer Cells	14
Decoding the Mechanism of Specific RNA Targeting by Ribosomal Methyltransferases	14
Targeting Protein Interaction Hotspots Using Structured and Disordered Chimeric Peptide Inhibitors	14
A Tandem-Affinity Purification Method for Identification of Primary Intracellular Drug-Binding Proteins	14
Cooperative Membrane Damage as a Mechanism for Pentamidine–Antibiotic Mutual Sensitization	14
Issue Publication Information	14
Treatment of Respiratory Distress Syndrome with Single Recombinant Polypeptides that Combine Features of SP-B and SP-C	14
Correction to “Suppression of DNA Polymerase β Activity is Synthetically Lethal in BRCA1-Deficient Cells”	14
Biosynthesis of Bacillus Phosphonoalamides Reveals Highly Specific Amino Acid Ligation	14
Phage Display of Two Distinct Warheads to Inhibit Challenging Proteins	14
Issue Publication Information	13
A Review of Chemical Tools for Studying Small Molecule Persulfides: Detection and Delivery	13
Engineered SH2 Domains for Targeted Phosphoproteomics	13
Class IIb Microcin MccM Interferes with Oxidative Phosphorylation in Escherichia coli	13
The Base-Editing Enzyme APOBEC3A Catalyzes Cytosine Deamination in RNA with Low Proficiency and High Selectivity	13
General Approach to Identify, Assess, and Characterize Inhibitors of Lipid Peroxidation and Associated Cell Death	13
DNA-Encoded Library Technology─A Catalyst for Covalent Ligand Discovery	13
Cytochrome P450 Mining for Bufadienolide Diversification	13
Switching Prenyl Donor Specificities in Squalene Synthase-Like Aromatic Prenyltransferases from Bacterial Carbazole Alkaloid Biosynthesis	13
Issue Editorial Masthead	13
Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion	13
Biotin as a Reactive Handle to Selectively Label Proteins and DNA with Small Molecules	13
Introducing Our Authors	13
Kinetic and Thermodynamic Insights into Agonist Interactions with the Parathyroid Hormone Receptor-1 from a New NanoBRET Assay	13
MicroED as a Powerful Tool for Structure Determination of Macrocyclic Drug Compounds Directly from Their Powder Formulations	13
Galectin-9 Signaling Drives Breast Cancer Invasion through Extracellular Matrix	13
Selection of Optimal Cell Lines for High-Content Phenotypic Screening	13
Genome-wide CRISPR Screening to Identify Drivers of TGF-β-Induced Liver Fibrosis in Human Hepatic Stellate Cells	13
Improved Electrophile Design for Exquisite Covalent Molecule Selectivity	13
Machine Learning Uncovers Natural Product Modulators of the 5-Lipoxygenase Pathway and Facilitates the Elucidation of Their Biological Mechanisms	13
Dual-Mechanism Confers Self-Resistance to the Antituberculosis Antibiotic Capreomycin	13
Discovery of Cyclic Lipopeptides Ralstopeptins A and B from Ralstonia solanacearum Species Complex and Analysis of Biosynthetic Gene Evolution	13
Rapid Evaluation of Staple Placement in Stabilized α Helices Using Bacterial Surface Display	13
Acarbose May Function as a Competitive Exclusion Agent for the Producing Bacteria	13
Tandem Chemoimmunotherapy by a Cascade-Responsive Molecular Prodrug	12
Structure and Biosynthesis of Hectoramide B, a Linear Depsipeptide from Marine Cyanobacterium Moorena producens JHB Discovered via Coculture with Candida albicans	12
Chemoenzymatic Synthesis of Novel Cytotoxic Epoxyketones Using the Eponemycin Biosynthetic Enzyme EpnF	12
Unraveling the Photoactivation Mechanism of a Light-Activated Adenylyl Cyclase Using Ultrafast Spectroscopy Coupled with Unnatural Amino Acid Mutagenesis	12
Synthesis of Differentially Halogenated Lissoclimide Analogues To Probe Ribosome E-Site Binding	12
Identification, Heterologous Expression, and Characterization of the Tolypodiol Biosynthetic Gene Cluster through an Integrated Approach	12
Identification of DDX5 as a Potential Therapeutic Target of Osteosarcoma Using Thiazolone Probes	12
Pharmacological Advantage of SIRT2-Selective versus pan-SIRT1–3 Inhibitors	12
Structure and Energetics of GTP- and GDP-Tubulin Isodesmic Self-Association	12
HSP27 Inhibitory Activity against Caspase-3 Cleavage and Activation by Caspase-9 Is Enhanced by Chaperone O-GlcNAc Modification in Vitro	12
Immunogenicity Evaluation of N-Glycans Recognized by HIV Broadly Neutralizing Antibodies	12
A C-Degron Structure-Based Approach for the Development of Ligands Targeting the E3 Ligase TRIM7	12
Structural Characterization of Degrader-Induced Ternary Complexes Using Hydrogen–Deuterium Exchange Mass Spectrometry and Computational Modeling: Implications for Structure-Based Design	12
European Robin Cryptochrome-4a Associates with Lipid Bilayers in an Ordered Manner, Fulfilling a Molecular-Level Condition for Magnetoreception	12
Bioinformatic Searching for Optimal RNA Targets of Dimeric Compounds Informs Design of a MicroRNA-27a Inhibitor	12
Charge Assisted S/Se Chalcogen Bonds in SAM Riboswitches: A Combined PDB and ab Initio Study	12
Time-Dependent Studies of Oxaliplatin and Other Nucleolar Stress-Inducing Pt(II) Derivatives	12
Screening a Molecular Fragment Library to Modulate the PED/PEA15-Phospholipase D1 Interaction in Cellular Lysate Environments	12
Engineered Glycan-Binding Proteins for Recognition of the Thomsen–Friedenreich Antigen and Structurally Related Disaccharides	12
Issue Publication Information	12
High-Resolution Substrate Specificity Profiling of SARS-CoV-2 M^pro; Comparison to SARS-CoV M^pro	12
Sustainable B₁₂-Dependent Dehalogenation of Organohalides in E. coli	12
Chemical Scaffolds for the Clinical Development of Mutant-Selective and Reversible Fourth-Generation EGFR-TKIs in NSCLC	12
Metabolic Investigation and Auxiliary Enzyme Modelization of the Pyrrocidine Pathway Allow Rationalization of Paracyclophane-Decahydrofluorene Formation	12
Brominated Carbazole with Antibiotic Adjuvant Activity Displays Pleiotropic Effects in MRSA’s Transcriptome	12
Identification of a Selective Pharmacologic IRE1/XBP1s Activator with Enhanced Tissue Exposure	12
Extrapolating Lessons from Targeted Protein Degradation to Other Proximity-Inducing Drugs	12
Targeted Degradation of mRNA Decapping Enzyme DcpS by a VHL-Recruiting PROTAC	12
Genetically Encoded Benzoyllysines Serve as Versatile Probes for Interrogating Histone Benzoylation and Interactions in Living Cells	12
Mechanistic Insights into Harmine-Mediated Inhibition of Human DNA Methyltransferases and Prostate Cancer Cell Growth	12