OOIR: Observatory of International Research

Papers

(The TQCC of ACS Chemical Biology is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Introducing Our Authors	140
Discovery and Validation of a Novel Class of Necroptosis Inhibitors Targeting RIPK1	85
Multi-TACs: Targeting Solid Tumors with Multiple Immune Cell Co-engagers	77
Correction to “Characterization of the Iron–Sulfur Cluster in the NCOA4 Fragment (383–522) and Its Interaction with Ferritin”	75
Issue Publication Information	57
Issue Editorial Masthead	52
In Situ Labeling of Pathogenic Tau Using Photo-Affinity Chemical Probes	51
Biosynthesis of Physcion and Identification of an O-Methyltransferase with C6–OH Selectivity in Aspergillus chevalieri BYST01	50
Enzymatic Pathway for Kupyaphore Degradation in Mycobacterium tuberculosis: Mechanism of Metal Homeostasis and Turnover	49
Enzymatic Macrolactamization of mRNA Display Libraries for Inhibitor Selection	49
Molecular Targeted Engagement of DPP9 in Rat Tissue Using CETSA, SP3 Processing, and Absolute Quantitation Mass Spectrometry	45
Simple Enzymatic Incorporation of 2′OMeU Nucleotide at the End of the Poly-A Tail for Enhancement of the mRNA Stability and Protein Expression	45
Chemical Synthetic Lethality Screens Identify Selective Drug Combinations against Pseudomonas aeruginosa	44
Dynamic Regulation of 5-Formylcytidine on tRNA	42
Spatiotemporal Proximity Labeling Tools to Track GlcNAc Sugar-Modified Functional Protein Hubs during Cellular Signaling	41
A Robust α-l-Fucosidase from Prevotella nigrescens for Glycoengineering Therapeutic Antibodies	41
Antimicrobial Lasso Peptide Cloacaenodin Utilizes a Unique TonB-Dependent Transporter to Access Susceptible Bacteria	40
Li-BrU-seq: A Low-Input and Simplified Metabolic Labeling Method for Nascent RNA Sequencing	39
Exploring Metalloproteome Remodeling in Calprotectin-Stressed Acinetobacter baumannii Using Chemoproteomics	38
An Inherent Difference between Serine and Threonine Phosphorylation: Phosphothreonine Strongly Prefers a Highly Ordered, Compact, Cyclic Conformation	36
Targeting IRAK3 for Degradation to Enhance IL-12 Pro-inflammatory Cytokine Production	36
Target-Responsive DNA Hydrogels with Encapsulation and Release Properties Using Programmable CRISPR-Cas12a	35
Robust Chemoenzymatic Synthesis of Keratinimicin Aglycone Analogues Facilitated by the Structure and Selectivity of OxyB	35
A Nonfunctional Halogenase Masquerades as an Aromatizing Dehydratase in Biosynthesis of Pyrrolic Polyketides by Type I Polyketide Synthases	34
Self-Avoiding Gamma Peptide Nucleic Acids for Selective Targeting of RNA Secondary Structures	32

Cell-Impermeable Hsp90α-Selective Inhibitor NDNA4 Inhibits Cancer Cell Migration and Targets Extracellular Hsp90α’s Critical F-5 Fragment	32
Structural and Biochemical Insights into Lignin-Oxidizing Activity of Bacterial Peroxidases against Soluble Substrates and Kraft Lignin	31
HiBiT-SpyTag: A Minimal Tag for Covalent Protein Capture and Degrader Development	31
Ferroptosis Inhibitors Suppress Prostaglandin Synthesis in Lipopolysaccharide-Stimulated Macrophages	31
Reengineering of Circularly Permuted Caspase-2 to Enhance Enzyme Stability and Enable Crystallographic Studies	30
Mechanistic Studies on Dehydration in Class V Lanthipeptides	30
Covalent Catalytic Strategies for Enzymes That Modify RNA Molecules on their Tripartite Building Blocks	30
Repurposing of the RIPK1-Selective Benzo[1,4]oxazepin-4-one Scaffold for the Development of a Type III LIMK1/2 Inhibitor	30
Christopher T. Walsh: A Prolific Scientist, Effective Academic Leader, and Responsive Mentor	29
Issue Publication Information	28
Issue Editorial Masthead	28
Issue Editorial Masthead	28
Issue Publication Information	28
Labeling of CC Chemokine Receptor 2 with a Versatile Intracellular Allosteric Probe	27
Engineering a Low-Immunogenic Mirror-Image VHH against Vascular Endothelial Growth Factor	27
Inhibitors of the PqsR Quorum-Sensing Receptor Reveal Differential Roles for PqsE and RhlI in Control of Phenazine Production	27
C₃-Symmetric Aromatic Core of Griffithsin Is Essential for Potent Anti-HIV Activity	27
Laboratory Evolution of Metalloid Reductase Substrate Recognition and Nanoparticle Product Size	27
Analysis of the Valgamicin Biosynthetic Pathway Reveals a General Mechanism for Cyclopropanol Formation across Diverse Natural Product Scaffolds	27
Photoactivatable Plant Hormone-Based Chemical Inducers of Proximity for In Vivo Applications	26
Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization	26
Chemical Genetics in C. elegans Identifies Anticancer Mycotoxins Chaetocin and Chetomin as Potent Inducers of a Nuclear Metal Homeostasis Response	26
Exploring Protein S-Palmitoylation: Mechanisms, Detection, and Strategies for Inhibitor Discovery	26
Lanmodulin’s EF 2–3 Domain: Insights from Infrared Spectroscopy and Simulations	26
MYC-Targeting PROTACs Lead to Bimodal Degradation and N-Terminal Truncation	25
Design of Class I/IV Bromodomain-Targeting Degraders for Chromatin Remodeling Complexes	25
An RNA Methylation-Sensitive AIEgen-Aptamer Reporting System for Quantitatively Evaluating m⁶A Methylase and Demethylase Activities	25
Light-Inducible Activation of TrkA for Probing Chronic Pain in Mice	25
Structure–Activity Relationships of Anabaenopeptins as Carboxypeptidase and Phosphatase Inhibitors	25
ATP Regeneration by Polyphosphate Kinase Powers Efficient Oligosaccharide Synthesis Catalyzed by Glycoside Phosphorylases	25
Phage Display Selection against a Mixture of Protein Targets	25
Targeted Discovery of Cryptic Enediyne Natural Products via FRET-Coupled High-Throughput Elicitor Screening	25
Issue Editorial Masthead	24
Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5	24
2-Cyanopyrimidine-Containing Molecules for N-Terminal Selective Cyclization of Phage-Displayed Peptides	24
Clotrimazole-Based Modulators of the TRPM3 Ion Channel Reveal Narrow Structure–Activity Relationship	24
Taxodione Inhibits Glioblastoma Proliferation and Potentiates the Cytotoxicity of Paclitaxel	24
Small-Molecule FICD Inhibitors Suppress Endogenous and Pathologic FICD-Mediated Protein AMPylation	24
Chemical Probes that Target a Dissociative LuxR-Type Quorum Sensing Receptor in Gram-Negative Bacteria	24
What Is the Crystallographic Resolution of Structural Models of Proteins Generated with AlphaFold2?	24
Native Aminoacyl-tRNA Synthetase/tRNA Pair Drives Highly Efficient Noncanonical Amino Acid Incorporation in Escherichia coli	23
Insights into Substrate Recognition by the Unusual Nitrating Enzyme RufO	23
Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective Modulators	23
Comparative Analysis of Drug-like EP300/CREBBP Acetyltransferase Inhibitors	23
Synthesis and Properties of RNA Modified with Cationic Amine Internucleoside Linkage	23
PPARγ Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles	23
Multiparametric High-Content Cell Painting Identifies Copper Ionophores as Selective Modulators of Esophageal Cancer Phenotypes	23
SETDB1 Triple Tudor Domain Ligand, ( R , R )-59, Promotes Methylation of Akt1 in Cells	22
Directed Evolution of PD-L1-Targeted Affibodies by mRNA Display	22
Evaluation of Thiosaccharides as Carbohydrate-Based Slow-Releasing Hydrogen Sulfide Donors	22

A Novel Lysosome Targeting Chimera for Targeted Protein Degradation via Split-and-Mix Strategy	22
Genome Mining of Sphingopyxis sp. MG Uncovers an Enzyme with Dual Catalytic Activity of Haloalkane Dehalogenase and Epoxide Hydrolase	22
Genome-Guided Discovery of the Myxobacterial Thiolactone-Containing Sorangibactins	22
Identification of Rapaglutin E as an Isoform-Specific Inhibitor of Glucose Transporter 1	22
Beyond KRAS(G12C): Biochemical and Computational Characterization of Sotorasib and Adagrasib Binding Specificity and the Critical Role of H95 and Y96	22
Evaluating Linker Architecture in RNA-Detecting Riboglow Probes and Effects on Fluorescence Turn-On	22
Convergent Alterations of a Protein Hub Produce Divergent Effects within a Binding Site	22
Optimizing Peptide-Conjugated Lipid Nanoparticles for Efficient siRNA Delivery across the Blood–Brain Barrier and Treatment of Glioblastoma Multiforme	21
Bifunctional Sesquiterpene/Diterpene Synthase Agr2 from Cyclocybe aegerita Gives Rise to the Novel Diterpene Cyclocybene	21
Fitness Landscape-Guided Engineering of Locally Supercharged Virus-like Particles with Enhanced Cell Uptake Properties	21
Structures of Methanomethylophilus alvus Pyrrolysine tRNA-Synthetases Support the Need for De Novo Selections When Altering the Substrate Specificity	21
Tryptamine Metabolism and Functionalization in Gut Commensal Bacteria Expand Human Tryptamine Signaling Responses	21
Biosynthesis of the Azoxy Compound Azodyrecin from Streptomyces mirabilis P8-A2	20
Bioproduction of a Large-Scale Library of Tryptamine Derivatives for Neuropsychiatric Drug Screening	20
Dynamic S -Acylation of GSDMA Regulates Pyroptosis	20
A Plastic Biosynthetic Pathway for the Production of Structurally Distinct Microbial Sunscreens	20
A Multi-Split-and-Mix Platform for a Variety of Targeted Protein Degradation	20
Drug-Like Small Molecules That Inhibit Expression of the Oncogenic MicroRNA-21	20
Enzymatic Bromination of Native Peptides for Late-Stage Structural Diversification via Suzuki–Miyaura Coupling	20
Photocaged Chloroquine Derivatives for the Light-Dependent Inhibition of Autophagy in Cancer Stem Cells	20
Widespread, Reversible Cysteine Modification by Methylglyoxal Regulates Metabolic Enzyme Function	19
Insights into Free Drug Release from Efficacious N-Acyl O-Aminophenol Duocarmycin Prodrugs	19
Issue Editorial Masthead	19
Correction to “Analysis of the Sequence Preference of Saporin by Deep Sequencing”	19
Chemical Approaches To Investigate Post-transcriptional RNA Regulation	19
Endogenous ROS-Mediated Covalent Immobilization of Gold Nanoparticles in Mitochondria: A “Sharp Sword” in Tumor Radiotherapy	19
Issue Publication Information	19
In Silico Discovery of Group II Intron RNA Splicing Inhibitors	19
Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct	19
Biphasic Cellular Response Triggered by Tetrandrine-Mediated Dysfunction and Lysophagic Clearance of Lysosomes	19
Issue Editorial Masthead	19
Issue Publication Information	18
Chemoproteomic Profiling Reveals the Mechanism of Bile Acid Tolerance in Bacteria	18
The Relationship between Substrate Structure and Selectivity of Ketoreduction in Multimodular Polyketide Synthases: A Comparative Study of A-Type Ketoreductases from Late Modules Using Complex Precurs	18
Genome Mining of Myxopeptins Reveals a Class of Lanthipeptide-Derived Linear Dehydroamino Acid-Containing Peptides from Myxococcus sp. MCy9171	18
Mapping snoRNA Targets Transcriptome-Wide with snoKARR-seq	18
G Protein-Biased Agonists for Intracellular Angiotensin Receptors Promote Collagen Secretion in Myofibroblasts	18
Chemical Probe Approach Reveals Endo-α-mannosidase Triages Misfolded Glycoproteins in the Calnexin/Calreticulin Cycle	17
Site-Specific Introduction of Alanines for the Nuclear Magnetic Resonance Investigation of Low-Complexity Regions and Large Biomolecular Assemblies	17
In Vivo Metabolic Labeling with an Isoprenoid Probe Reveals APOE Allele-Specific Differences in the Prenylome	17
Advances in Optogenetics and Thermogenetics for Control of Non-Neuronal Cells and Tissues in Biomedical Research	17
Chemoenzymatic Probes Reveal Peptidoglycan Recognition and Uptake Mechanisms in Candida albicans	17
Development of Comprehensive Screening and Assessment Assays for Small-Molecule Ligands of MALAT1 lncRNA	17
Characterization of Chemical Interactions between Clinical Drugs and the Oral Bacterium, Corynebacterium matruchotii, via Bioactivity-HiTES	17
Screen for Modulation of Nucleocapsid Protein Condensation Identifies Small Molecules with Anti-Coronavirus Activity	17
Multivalent Peptide-DNA Conjugates Facilitate DNA Internalization in Cells Expressing Glycosaminoglycans	17
Multimodal Blood-Based Biomarker Panel Reveals Altered Lysosomal Ionic Content in Alzheimer’s Disease	17
Structural, Biochemical, and Bioinformatic Basis for Identifying Radical SAM Cyclopropyl Synthases	17
Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity	17
Discovery of Small-Molecule Inhibitors of the Pycsar Antiphage Defense	17
Stable Isotope-Guided Metabolomics Reveals Polar-Functionalized Fatty-Acylated RiPPs from Streptomyces	16
Discovery of a Compound That Inhibits IRE1α S-Nitrosylation and Preserves the Endoplasmic Reticulum Stress Response under Nitrosative Stress	16
Correction to “A cAMP Sensor Based on Ligand-Dependent Protein Stabilization”	16
Decoding Protein–Peptide Interactions Using a Large, Target-Agnostic Yeast Surface Display Library	16
Pathogenic SNPs Affect Both RNA and DNA G-Quadruplexes’ Responses to Ligands	16
Natural Product-Derived Ianthelliformisamines Inhibit Protein Translation and Block Bacterial Flagellum Assembly	16
Issue Publication Information	16
Drugging the Sarcomere, a Delicate Balance: Position of N-Terminal Charge of the Inhibitor W7	16
Mechanistic Analysis of Bioorthogonal Double Strain-Promoted Alkyne–Nitrone Cycloadditions Involving Dibenzocyclooctadiyne	16
Phage Selection of Cyclic Peptides Inhibiting Aminoglycoside Phosphotransferases to Control Resistant Bacteria	16
Metabolic Glycan Labeling in Primary Neurons Enabled by Unnatural Sugars with No S-Glyco-Modification	16
Authentic Phosphorylation of α-Synuclein at Ser129 Reveals Functional Differences Not Captured by the S129D Phosphomimetic	16
Adenylation Domain-Guided Recruitment of Trans-Acting Nonheme Monooxygenases in Nonribosomal Peptide Biosynthesis	16
Issue Publication Information	16
Identification of Chemical Probes Targeting MBD2	15
Elucidating the Ferroptotic Black Box: Radical-Trapping Antioxidant Probes Illuminate Subcellular Onset and Progression	15
Introducing Our Authors	15
Reversible Antagonism of Dopamine D1 Receptor Using a Photoswitchable Remotely Tethered Ligand	15
New High-Throughput Screen Discovers Novel Ligands of Full-Length Nuclear Receptor LRH-1	15
Decay of Piwi-Interacting RNAs in Human Cells Is Primarily Mediated by 5′ to 3′ Exoribonucleases	15
The Impact of Sugar Conformation on the Single-Stranded DNA Selectivity of APOBEC3A and APOBEC3B Enzymes	15
CRISPR RiPCA for Investigating eIF4E-m⁷GpppX Capped mRNA Interactions	15
Visualizing Intracellular Localization of Natural-Product-Based Chemical Probes Using Click-Correlative Light and Electron Microscopy	15
Neurotoxic Implications of Human Coronaviruses in Neurodegenerative Diseases: A Perspective from Amyloid Aggregation	15
Studies Pertaining to the Emerging Cannabinoid Hexahydrocannabinol (HHC)	15
Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the Chemokine Receptor CCR2	15
Uncovering the Association Mechanism between Two Intrinsically Flexible Proteins	15
High-Throughput Activity Reprogramming of Proteases (HARP)	15
Structural Insights into Spare-Tire DNA G-Quadruplex from the Human VEGF Promoter	15
Discovery and Mechanism of 16–19F, a Novel Synthetic Lethal Inhibitor of the PRMT5•MTA Complex in MTAP-Deleted Cancer Cells	15

Structural Insights and Reaction Profile of a New Unspecific Peroxygenase from Marasmius wettsteinii Produced in a Tandem-Yeast Expression System	15
Enhancing the Anticancer Activity of Attenuated Listeria monocytogenes by Cell Wall Functionalization with “Clickable” Doxorubicin	14
A Repurposed Drug Interferes with Nucleic Acid to Inhibit the Dual Activities of Coronavirus Nsp13	14
Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an S_Ni Mechanism and Ion Pair Transition State	14
Regulatory and Catalytic Domains of Poly(ADP-ribose) Polymerases Cross-Complement for DNA-Break-Dependent Allosteric Stimulation of Catalytic Activity	14
Targeted Protein Degradation through Recruitment of the CUL4 Complex Adaptor Protein DDB1	14
Phage Display of Two Distinct Warheads to Inhibit Challenging Proteins	14
Real-Time Cellular Thermal Shift Assay to Monitor Target Engagement	14
Machine Learning Uncovers Natural Product Modulators of the 5-Lipoxygenase Pathway and Facilitates the Elucidation of Their Biological Mechanisms	14
Discovery of Cyclic Lipopeptides Ralstopeptins A and B from Ralstonia solanacearum Species Complex and Analysis of Biosynthetic Gene Evolution	14
Kinetic and Thermodynamic Insights into Agonist Interactions with the Parathyroid Hormone Receptor-1 from a New NanoBRET Assay	14
Fungal NRPS-PKS Hybrid Enzymes Biosynthesize New γ-Lactam Compounds, Taslactams A-D, Analogous to Actinomycete Proteasome Inhibitors	14
Modulation of Core-Fucosylation Oxidation for Selective Enrichment and Characterization of Cell Surface Glycoprotein	14
Engineering H₂S-Activatable Aptameric Binders for Tailored Cell Manipulation	14
4″-Methyl- S -Adenosyl- l -Methionines Are Substrates for 4-Methylazetidinecarboxylic Acid Synthases	14
Omniligase-1-Mediated Phage-Peptide Library Modification and Insulin Engineering	14
MicroED as a Powerful Tool for Structure Determination of Macrocyclic Drug Compounds Directly from Their Powder Formulations	14
Design, Synthesis, and Mechanistic Studies of (R)-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase	14
Cytochrome P450 Mining for Bufadienolide Diversification	14
A Scavenger Hunt for a DyP-Peroxidase from a Metagenome: Curated Peroxidase Database-Assisted Primer Design and Protein Structure Elucidation	14
Protein-Labeling Reagents Selectively Activated by Copper(I)	14
A Fluorescence Polarization Assay for Macrodomains Facilitates the Identification of Potent Inhibitors of the SARS-CoV-2 Macrodomain	14
Introducing Our Authors	14
Borinic Acid-Based Fluorogenic Probes as an Alternative to the Amplex Red Assay for Real-Time H₂O₂ Monitoring in Live Cells	14
A Tandem-Affinity Purification Method for Identification of Primary Intracellular Drug-Binding Proteins	14
Elucidating the Role of the Competence Regulon Quorum Sensing Circuitry in Streptococcus cristatus	14
Novel Substrate Prediction for the TAM Family of RTKs Using Phosphoproteomics and Structure-Based Modeling	14
Dual-Probe Activity-Based Protein Profiling Reveals Site-Specific Differences in Protein Binding of EGFR-Directed Drugs	14
Issue Publication Information	14
The Endoplasmic Reticulum-Located TRPV1 Channel Is Not Thermal Sensitive	14
Leveraging Covalency to Stabilize Ternary Complex Formation For Cell–Cell “Induced Proximity”	13
Localized Light-Triggered CO Delivery: Comparing the Amount of CO Delivered and Cellular Toxicity	13
Improved Electrophile Design for Exquisite Covalent Molecule Selectivity	13
Selection of Optimal Cell Lines for High-Content Phenotypic Screening	13
microRNAs Regulate Cellular Magnesium by Tuning Expression of the Plasma Membrane Protein CNNM4	13
Rapid Evaluation of Staple Placement in Stabilized α Helices Using Bacterial Surface Display	13
Acarbose May Function as a Competitive Exclusion Agent for the Producing Bacteria	13
General Approach to Identify, Assess, and Characterize Inhibitors of Lipid Peroxidation and Associated Cell Death	13
DNA-Encoded Library Technology─A Catalyst for Covalent Ligand Discovery	13
Metabolic Investigation and Auxiliary Enzyme Modelization of the Pyrrocidine Pathway Allow Rationalization of Paracyclophane-Decahydrofluorene Formation	13
Engineered SH2 Domains for Targeted Phosphoproteomics	13
Manipulation of Global Regulator mcrA Activates the Fumigermin Pathway in Penicillium camemberti IMV00769	13
Biosynthesis of Bacillus Phosphonoalamides Reveals Highly Specific Amino Acid Ligation	13
Targeting Protein Interaction Hotspots Using Structured and Disordered Chimeric Peptide Inhibitors	13
A Bispecific Antibody Engineering Strategy for Effective Dual-Target Degradation of Cell-Surface and Secreted Oncoproteins with Superior Antitumor Activity	13
Selective Targeting of Protein Arginine Methyltransferase 1 (PRMT1) Mutant Activity by a Small Molecule Activation Strategy	13
Introducing Our Authors	13
Galectin-9 Signaling Drives Breast Cancer Invasion through Extracellular Matrix	13
Class IIb Microcin MccM Interferes with Oxidative Phosphorylation in Escherichia coli	13
Switching Prenyl Donor Specificities in Squalene Synthase-Like Aromatic Prenyltransferases from Bacterial Carbazole Alkaloid Biosynthesis	13
fpocketR : A Platform for Identification and Analysis of Ligand-Binding Pockets in RNA	13
Cooperative Membrane Damage as a Mechanism for Pentamidine–Antibiotic Mutual Sensitization	13
Development of a New DHFR-Based Destabilizing Domain with Enhanced Basal Turnover and Applicability in Mammalian Systems	13
Systematic Study of the Impact of DNA Interstrand Cross-Links on Nucleosome Structure, Sliding, and Transcription	12
Membrane Vesicle-Mediated Delivery of Antibacterial Lipopeptides by Pseudoalteromonas piscicida	12
Identification of a Selective Pharmacologic IRE1/XBP1s Activator with Enhanced Tissue Exposure	12
Cyclic γ-AApeptide-Based Molecular Glues for RNA m ⁶ A Editing	12
Select Azo Compounds Post-translationally Modulate HTRA1 Abundance and Activity Potentially through Interactions at the Trimer Interface	12
Issue Publication Information	12
Origin of the Different Binding Affinities of (9R)- and (9S)-Hexahydrocannabinol (HHC) for the CB₁ and CB₂ Cannabinoid Receptors	12
Sustainable B₁₂-Dependent Dehalogenation of Organohalides in E. coli	12
Metabolic Tracing of Methyl Donor Utilization in Histone Methylation via Relative Quantification of Isotopomer Distribution Mass Spectrometry	12
Identification of DDX5 as a Potential Therapeutic Target of Osteosarcoma Using Thiazolone Probes	12
Consequences of Peptide Macrocyclization Revealed by Virus-Inspired β-Hairpin Mimetics	12
Generating Efficient Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetases for Structurally Diverse Non-Canonical Amino Acids	12
Chemoenzymatic Synthesis of Novel Cytotoxic Epoxyketones Using the Eponemycin Biosynthetic Enzyme EpnF	12
HSP27 Inhibitory Activity against Caspase-3 Cleavage and Activation by Caspase-9 Is Enhanced by Chaperone O-GlcNAc Modification in Vitro	12
Forward Genetic Screens Identify Mechanisms of Resistance to Small-Molecule Lactate Dehydrogenase Inhibitors	12
Dynamic Pathway of Guanidine-III Riboswitch Folding Revealed by Single-Molecule FRET: Mg ²⁺ -Assisted Preorganization and Ligand-Induced Kinetic Trap	12
Issue Editorial Masthead	12
Bacillus spp. Antibacterial Activity Induced by Triphenyl Tetrazolium Chloride against Ralstonia solanacearum: Oxidative Stress Response and Metabolome Changes	12
Engineered Glycan-Binding Proteins for Recognition of the Thomsen–Friedenreich Antigen and Structurally Related Disaccharides	12
Synthesis of Differentially Halogenated Lissoclimide Analogues To Probe Ribosome E-Site Binding	12
Donor-PeT Control of Intersystem Crossing Enables ALDH1A1-Activated Photodynamic Therapy	12
Targeted Degradation of mRNA Decapping Enzyme DcpS by a VHL-Recruiting PROTAC	12
Extrapolating Lessons from Targeted Protein Degradation to Other Proximity-Inducing Drugs	12
Time-Dependent Studies of Oxaliplatin and Other Nucleolar Stress-Inducing Pt(II) Derivatives	12
Chemical Scaffolds for the Clinical Development of Mutant-Selective and Reversible Fourth-Generation EGFR-TKIs in NSCLC	12
Structure and Biosynthesis of Hectoramide B, a Linear Depsipeptide from Marine Cyanobacterium Moorena producens JHB Discovered via Coculture with Candida albicans	12
Virus Propagation Linked to Exceedingly Rare Gene-Expression Errors: A Single-Molecule Microscopy Demonstration	12
Issue Publication Information	12
European Robin Cryptochrome-4a Associates with Lipid Bilayers in an Ordered Manner, Fulfilling a Molecular-Level Condition for Magnetoreception	12
Small-Molecule Covalent Stabilization and Inhibition of the TEAD·YAP1 Transcription Factor in Cancer Cells	12
Mechanistic Insights into Harmine-Mediated Inhibition of Human DNA Methyltransferases and Prostate Cancer Cell Growth	12
N-Arylpyrazole NOD2 Agonists Promote Immune Checkpoint Inhibitor Therapy	11
Conformational Frustration at the Protein–Glycan Interface of a Nonmitogenic Anti-HIV Lectin Results in Altered Quaternary Structure	11
Selective and Potent PROTAC Degraders of c-Src Kinase	11
Decarboxylase Activity of an Antibiotic Biosynthesis Monooxygenase Family Protein in the Biosynthesis of the Type II Polyketide Murayaquinone	11
Proximity Labeling Reveals Spatial Regulation of the Anaphase-Promoting Complex/Cyclosome by a Microtubule Adaptor	11
Phospholipids Differentially Regulate Ca²⁺ Binding to Synaptotagmin-1	11
Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target	11
Multiplex, Quantitative, High-Resolution Imaging of Protein:Protein Complexes via Hybridization Chain Reaction	11
PUFA-Derived N-Acylethanolamide Probes Identify Peroxiredoxins and Small GTPases as Molecular Targets in LPS-Stimulated RAW264.7 Macrophages	11
A “Goldilocks Zone” for Recruiting BET Proteins with Bromodomain-1-Selective Ligands	11
Engineered Branaplam Aptamers Exploit Structural Elements from Natural Riboswitches	11