ACS Chemical Biology

Article	Citations
A Useful Guide to Lectin Binding: Machine-Learning Directed Annotation of 57 Unique Lectin Specificities	140
m6A-RNA Demethylase FTO Inhibitors Impair Self-Renewal in Glioblastoma Stem Cells	109
A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells	81
LPCAT3 Inhibitors Remodel the Polyunsaturated Phospholipid Content of Human Cells and Protect from Ferroptosis	75
Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling	74
Modulation of Phosphoprotein Activity by Phosphorylation Targeting Chimeras (PhosTACs)	63
SARS-CoV-2 RBD-Tetanus Toxoid Conjugate Vaccine Induces a Strong Neutralizing Immunity in Preclinical Studies	63
Brightening up Biology: Advances in Luciferase Systems for in Vivo Imaging	57
Near-Infrared Fluorescent Probes for the Detection of Cancer-Associated Proteases	55
The SARS-CoV-2 Programmed −1 Ribosomal Frameshifting Element Crystal Structure Solved to 2.09 Å Using Chaperone-Assisted RNA Crystallography	50
CH−π Interactions in Glycan Recognition	47
Genetic Encoding of Three Distinct Noncanonical Amino Acids Using Reprogrammed Initiator and Nonsense Codons	45
Roadmap for Optimizing and Broadening Antibody-Based PROTACs for Degradation of Cell Surface Proteins	43
NanoClick: A High Throughput, Target-Agnostic Peptide Cell Permeability Assay	43
Plasmalogen Biosynthesis by Anaerobic Bacteria: Identification of a Two-Gene Operon Responsible for Plasmalogen Production in Clostridium perfringens	42
Chalcogen Bonds Involving Selenium in Protein Structures	42
Selective Transformations of Carbohydrates Inspired by Radical-Based Enzymatic Mechanisms	40
Carbohydrate Sulfation As a Mechanism for Fine-Tuning Siglec Ligands	39
Nitrogen–Nitrogen Bond Formation Reactions Involved in Natural Product Biosynthesis	39
Attenuation of NLRP3 Inflammasome Activation by Indirubin-Derived PROTAC Targeting HDAC6	37
Spatiotemporal Control of Biology: Synthetic Photochemistry Toolbox with Far-Red and Near-Infrared Light	37
l-Threonine Transaldolase Activity Is Enabled by a Persistent Catalytic Intermediate	36
Structural Characterization of Degrader-Induced Ternary Complexes Using Hydrogen–Deuterium Exchange Mass Spectrometry and Computational Modeling: Implications for Structure-Based Design	36
Development of a Red-Light-Controllable Nitric Oxide Releaser to Control Smooth Muscle Relaxation in Vivo	35
Machine Learning Classifies Ferroptosis and Apoptosis Cell Death Modalities with TfR1 Immunostaining	35

CRISPR Screen Reveals BRD2/4 Molecular Glue-like Degrader via Recruitment of DCAF16	35
High-Throughput Activity Assay for Screening Inhibitors of the SARS-CoV-2 Mac1 Macrodomain	34
Bioinformatics-Guided Expansion and Discovery of Graspetides	33
R-BIND 2.0: An Updated Database of Bioactive RNA-Targeting Small Molecules and Associated RNA Secondary Structures	33
Chemical Screen for Vancomycin Antagonism Uncovers Probes of the Gram-Negative Outer Membrane	32
Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1)	32
A Probe for NLRP3 Inflammasome Inhibitor MCC950 Identifies Carbonic Anhydrase 2 as a Novel Target	32
Profiling Sulfur(VI) Fluorides as Reactive Functionalities for Chemical Biology Tools and Expansion of the Ligandable Proteome	32
Inhibitor Mimetic Mutations in the Pseudomonas aeruginosa PqsE Enzyme Reveal a Protein–Protein Interaction with the Quorum-Sensing Receptor RhlR That Is Vital for Virulence Factor Production	32
Non-Histone Protein Methylation: Biological Significance and Bioengineering Potential	31
Cell Morphological Profiling Enables High-Throughput Screening for PROteolysis TArgeting Chimera (PROTAC) Phenotypic Signature	31
Structural Analysis of Class I Lanthipeptides from Pedobacter lusitanus NL19 Reveals an Unusual Ring Pattern	31
First Small-Molecule Inhibitors Targeting the RNA-Binding Protein IGF2BP2/IMP2 for Cancer Therapy	31
Optimization of Metabolic Oligosaccharide Engineering with Ac4GalNAlk and Ac4GlcNAlk by an Engineered Pyrophosphorylase	30
Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions	30
Chemical Diversification of Simple Synthetic Antibodies	30
Mucinomics as the Next Frontier of Mass Spectrometry	30
Fluorescence Anisotropy-Based Tethering for Discovery of Protein–Protein Interaction Stabilizers	30
Allosteric Inhibition of Parkinson’s-Linked LRRK2 by Constrained Peptides	29
Protein Folding Stability Changes Across the Proteome Reveal Targets of Cu Toxicity in E. coli	29
A Gut-Restricted Lithocholic Acid Analog as an Inhibitor of Gut Bacterial Bile Salt Hydrolases	29
General and Robust Chemoenzymatic Method for Glycan-Mediated Site-Specific Labeling and Conjugation of Antibodies: Facile Synthesis of Homogeneous Antibody–Drug Conjugates	28
Detection of SARS-CoV-2 RNA Using a DNA Aptamer Mimic of Green Fluorescent Protein	28
Genetic Incorporation of Two Mutually Orthogonal Bioorthogonal Amino Acids That Enable Efficient Protein Dual-Labeling in Cells	28
Bioinformatic and Reactivity-Based Discovery of Linaridins	28
The Promise and Peril of Chemical Probe Negative Controls	28
Uptake, Stability, and Activity of Antisense Anti-acpP PNA-Peptide Conjugates in Escherichia coli and the Role of SbmA	28
Configured for the Human Gut Microbiota: Molecular Mechanisms of Dietary β-Glucan Utilization	28
Development of an Acrylamide-Based Inhibitor of Protein S-Acylation	28
Role of Iron in the Molecular Pathogenesis of Diseases and Therapeutic Opportunities	28
Improvement of Phycocyanobilin Synthesis for Genetically Encoded Phytochrome-Based Optogenetics	27
Cereblon Modulators Target ZBTB16 and Its Oncogenic Fusion Partners for Degradation via Distinct Structural Degrons	27
Prenylation and Dehydrogenation of a C2-Reversely Prenylated Diketopiperazine as a Branching Point in the Biosynthesis of Echinulin Family Alkaloids in Aspergillus ruber	27
A Review of Chemical Tools for Studying Small Molecule Persulfides: Detection and Delivery	27
Blinking Fluorescent Probes for Tubulin Nanoscopy in Living and Fixed Cells	26
The Angiopoietin-Like Protein 3 and 8 Complex Interacts with Lipoprotein Lipase and Induces LPL Cleavage	26
Site-Specific Chemoenzymatic Conjugation of High-Affinity M6P Glycan Ligands to Antibodies for Targeted Protein Degradation	25
Mechanistic Studies on Dehydration in Class V Lanthipeptides	25
Live-Cell Fluorescence Lifetime Multiplexing Using Synthetic Fluorescent Probes	25
Site-Specific Lipidation Enhances IFITM3 Membrane Interactions and Antiviral Activity	24
A DNA Aptamer for Theophylline with Ultrahigh Selectivity Reminiscent of the Classic RNA Aptamer	24
High-Speed Diagnosis of Bacterial Pathogens at the Single Cell Level by Raman Microspectroscopy with Machine Learning Filters and Denoising Autoencoders	24
Chemical Phosphoproteomics Sheds New Light on the Targets and Modes of Action of AKT Inhibitors	24
Genome Mining Discovery of Protegenins A–D, Bacterial Polyynes Involved in the Antioomycete and Biocontrol Activities of Pseudomonas protegens	23
Short Photoswitchable Ceramides Enable Optical Control of Apoptosis	23
Enzymatic Formation of an Artificial Base Pair Using a Modified Purine Nucleoside Triphosphate	23
The Nobel Prize in Chemistry 2022: Fulfilling Demanding Applications with Simple Reactions	23
Comparison of N-Acetyl-Glucosamine to Other Monosaccharides Reveals Structural Differences for the Inhibition of α-Synuclein Aggregation	23
YTHDF3 Facilitates eIF2AK2 and eIF3A Recruitment on mRNAs to Regulate Translational Processes in Oxaliplatin-Resistant Colorectal Cancer	23
m7G-quant-seq: Quantitative Detection of RNA Internal N7-Methylguanosine	22

Garcinol Is an HDAC11 Inhibitor	22
Cell-Specific Delivery Using an Engineered Protein Nanocage	22
YEATS Domains as Novel Epigenetic Readers: Structures, Functions, and Inhibitor Development	22
Strategies and Tactics for the Development of Selective Glycan-Binding Proteins	22
S-Palmitoylation and Sterol Interactions Mediate Antiviral Specificity of IFITMs	22
Bringing Vibrational Imaging to Chemical Biology with Molecular Probes	21
Quantitative and Site-Specific Chemoproteomic Profiling of Protein O-GlcNAcylation in the Cell Cycle	21
Bioactive Compounds of Arthrospira spp. (Spirulina) with Potential Anticancer Activities: A Systematic Review	21
Reversible O-Acetyl Migration within the Sialic Acid Side Chain and Its Influence on Protein Recognition	21
Base Pairing and Functional Insights into N3-Methylcytidine (m3C) in RNA	21
Ribosomal Synthesis of Macrocyclic Peptides with Linear γ4- and β-Hydroxy-γ4-amino Acids	21
Targeted Protein Degradation through E2 Recruitment	21
Outer Membrane Vesicle-Mediated Codelivery of the Antifungal HSAF Metabolites and Lytic Polysaccharide Monooxygenase in the Predatory Lysobacter enzymogenes	21
Quorum Sensing Inhibition Attenuates the Virulence of the Plant Pathogen Ralstonia solanacearum Species Complex	20
Affinity Mass Spectrometry-Based Fragment Screening Identified a New Negative Allosteric Modulator of the Adenosine A2A Receptor Targeting the Sodium Ion Pocket	20
Chemical Labeling and Enrichment of Histone Glyoxal Adducts	20
Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2	20
Identifying Receptors for Neuropeptides and Peptide Hormones: Challenges and Recent Progress	20
Short Peptides and Their Mimetics as Potent Antibacterial Agents and Antibiotic Adjuvants	20
Cysteine Hydropersulfide Inactivates β-Lactam Antibiotics with Formation of Ring-Opened Carbothioic S-Acids in Bacteria	20
Asparaginyl Ligase-Catalyzed One-Step Cell Surface Modification of Red Blood Cells	20
Ribosomal Synthesis of Macrocyclic Peptides with β2- and β2,3-Homo-Amino Acids for the Development of Natural Product-Like Combinatorial Libraries	20
ATE1-Mediated Post-Translational Arginylation Is an Essential Regulator of Eukaryotic Cellular Homeostasis	20
An Allosteric Modulator of RNA Binding Targeting the N-Terminal Domain of TDP-43 Yields Neuroprotective Properties	20
Mass Spectrometry-Based Technology and Workflows for Studying the Chemistry of Fungal Endophyte Derived Bioactive Compounds	20
Host Kinase CSNK2 is a Target for Inhibition of Pathogenic SARS-like β-Coronaviruses	20
The HPK1 Inhibitor A-745 Verifies the Potential of Modulating T Cell Kinase Signaling for Immunotherapy	20
Quantitative Measurement of Cytosolic and Nuclear Penetration of Oligonucleotide Therapeutics	19
Clinical Antiviral Drug Arbidol Inhibits Infection by SARS-CoV-2 and Variants through Direct Binding to the Spike Protein	19
Protected N-Acetyl Muramic Acid Probes Improve Bacterial Peptidoglycan Incorporation via Metabolic Labeling	19
The Structural and Biochemical Basis of Apocarotenoid Processing by β-Carotene Oxygenase-2	19
Tolerogenic Nanoparticles Impacting B and T Lymphocyte Responses Delay Autoimmune Arthritis in K/BxN Mice	19
Importance of the Cyclic Cystine Knot Structural Motif for Immunosuppressive Effects of Cyclotides	19
Fluorescence Lifetime Imaging of pH along the Secretory Pathway	19
Reactivity-Based Screening for Citrulline-Containing Natural Products Reveals a Family of Bacterial Peptidyl Arginine Deiminases	19
Facile Synthesis and Metabolic Incorporation of m-DAP Bioisosteres Into Cell Walls of Live Bacteria	19
Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the Chemokine Receptor CCR2	18
Optimization of PROTAC Ternary Complex Using DNA Encoded Library Approach	18
Pharmacological Advantage of SIRT2-Selective versus pan-SIRT1–3 Inhibitors	18
Stabilization of Protein–Protein Interactions between CaMKK2 and 14–3–3 by Fusicoccins	18
Amyloid Fibril Formation of Arctic Amyloid-β 1–42 Peptide is Efficiently Inhibited by the BRICHOS Domain	18
Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect	18
Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction	18
Tunable Heteroassembly of a Plant Pseudoenzyme–Enzyme Complex	18
A Highly Efficacious Carfentanil Vaccine That Blunts Opioid-Induced Antinociception and Respiratory Depression	17
Unraveling the Photoactivation Mechanism of a Light-Activated Adenylyl Cyclase Using Ultrafast Spectroscopy Coupled with Unnatural Amino Acid Mutagenesis	17
Single-Base Resolution Mapping Reveals Distinct 5-Formylcytidine in Saccharomyces cerevisiae mRNAs	17
Galectin-9 Signaling Drives Breast Cancer Invasion through Extracellular Matrix	17
Phenotype-Guided Comparative Genomics Identifies the Complete Transport Pathway of the Antimicrobial Lasso Peptide Ubonodin in Burkholderia	17
Chemical and Biochemical Reactivity of the Reduced Forms of Nicotinamide Riboside	17
Ratiometric Bioluminescent Zinc Sensor Proteins to Quantify Serum and Intracellular Free Zn2+	17
A Bifunctional NAD+ for Profiling Poly-ADP-Ribosylation-Dependent Interacting Proteins	17
Generation of a Large Peptide Phage Display Library by Self-Ligation of Whole-Plasmid PCR Product	17
Genomic-Led Discovery of a Novel Glycopeptide Antibiotic by Nonomuraea coxensis DSM 45129	17
Precipitate-Supported Thermal Proteome Profiling Coupled with Deep Learning for Comprehensive Screening of Drug Target Proteins	17
Dark Dynamic Therapy: Photosensitization without Light Excitation Using Chemiluminescence Resonance Energy Transfer in a Dioxetane–Erythrosin B Conjugate	17
A Minimalistic Coumarin Turn-On Probe for Selective Recognition of Parallel G-Quadruplex DNA Structures	17
Identification and Biosynthesis of Pro-Inflammatory Sulfonolipids from an Opportunistic Pathogen Chryseobacterium gleum	17
Structure-Guided Design of a Potent and Specific Inhibitor against the Genomic Mutator APOBEC3A	17
MetEx, a Metabolomics Explorer Application for Natural Product Discovery	17
Targeted Discovery of Cryptic Metabolites with Antiproliferative Activity	17
“Clickable” ZIF-8 for Cell-Type-Specific Delivery of Functional Proteins	16
C-Diazeniumdiolate Graminine in the Siderophore Gramibactin Is Photoreactive and Originates from Arginine	16
Systematic Assessment of Accessibility to the Surface of Staphylococcus aureus	16
Controlling the Production of Pseudomonas Phenazines by Modulating the Genetic Repertoire	16
Biosynthesis of the Nuclear Factor of Activated T Cells Inhibitor NFAT-133 in Streptomyces pactum	16
Subsite Ligand Recognition and Cooperativity in the TPP Riboswitch: Implications for Fragment-Linking in RNA Ligand Discovery	16
Exploring Methods of Targeting Histone Methyltransferases and Their Applications in Cancer Therapeutics	16
A Silent Biosynthetic Gene Cluster from a Methanotrophic Bacterium Potentiates Discovery of a Substrate Promiscuous Proteusin Cyclodehydratase	16
How cis-Acyltransferase Assembly-Line Ketosynthases Gatekeep for Processed Polyketide Intermediates	16
Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity	16
Substrate Recognition by the Peptidyl-(S)-2-mercaptoglycine Synthase TglHI during 3-Thiaglutamate Biosynthesis	16
A Comparison of Two Stability Proteomics Methods for Drug Target Identification in OnePot 2D Format	16
Inhibition of the GDP-d-Mannose Dehydrogenase from Pseudomonas aeruginosa Using Targeted Sugar Nucleotide Probes	16
Angler Peptides: Macrocyclic Conjugates Inhibit p53:MDM2/X Interactions and Activate Apoptosis in Cancer Cells	15
Rapid Multicomponent Bioluminescence Imaging via Substrate Unmixing	15
Mediated Electrochemical Probing: A Systems-Level Tool for Redox Biology	15
Equipping Natural Killer Cells with Cetuximab through Metabolic Glycoengineering and Bioorthogonal Reaction for Targeted Treatment of KRAS Mutant Colorectal Cancer	15
In Vitro Reconstitution of a Five-Step Pathway for Bacterial Ergothioneine Catabolism	15
Entropic Inhibition: How the Activity of a AAA+ Machine Is Modulated by Its Substrate-Binding Domain	15

Reconstitution and Structural Analysis of a HECT Ligase-Ubiquitin Complex via an Activity-Based Probe	15
Triple-Helical Binding of Peptide Nucleic Acid Inhibits Maturation of Endogenous MicroRNA-197	15
Kinase Photoaffinity Labeling Reveals Low Selectivity Profile of the IRE1 Targeting Imidazopyrazine-Based KIRA6 Inhibitor	15
Proof-Reading Thioesterase Boosts Activity of Engineered Nonribosomal Peptide Synthetase	15
Genetically Encoded Benzoyllysines Serve as Versatile Probes for Interrogating Histone Benzoylation and Interactions in Living Cells	15
The Base-Editing Enzyme APOBEC3A Catalyzes Cytosine Deamination in RNA with Low Proficiency and High Selectivity	15
Diverse Protein Architectures and α-N-Methylation Patterns Define Split Borosin RiPP Biosynthetic Gene Clusters	15
Orthosteric and Allosteric Dual Targeting of the Nuclear Receptor RORγt with a Bitopic Ligand	15
Adenosine Triggers Larval Settlement and Metamorphosis in the Mussel Mytilopsis sallei through the ADK-AMPK-FoxO Pathway	15
Rescue of Glycosylphosphatidylinositol-Anchored Protein Biosynthesis Using Synthetic Glycosylphosphatidylinositol Oligosaccharides	15
Addicting Escherichia coli to New-to-Nature Reactions	15
Structure–Activity Relationship of Metabolic Sialic Acid Inhibitors and Labeling Reagents	15
NMR-Based Metabolomics Approach to Explore Brain Metabolic Changes Induced by Prenatal Exposure to Autism-Inducing Chemicals	15
Chemically Modified mocRNAs for Highly Efficient Protein Expression in Mammalian Cells	15
Proximity Tagging Identifies the Glycan-Mediated Glycoprotein Interactors of Galectin-1 in Muscle Stem Cells	15
A Non-immunogenic Bivalent d-Protein Potently Inhibits Retinal Vascularization and Tumor Growth	15
Multiparametric High-Content Cell Painting Identifies Copper Ionophores as Selective Modulators of Esophageal Cancer Phenotypes	14
Homobivalent Dopamine D2 Receptor Ligands Modulate the Dynamic Equilibrium of D2 Monomers and Homo- and Heterodimers	14
Esterase-Activated Perthiocarbonate Persulfide Donors Provide Insights into Persulfide Persistence and Stability	14
Visualizing Conformational Ensembles of the Nucleosome by NMR	14
Glycosylation Regulates N-Terminal Proteolysis and Activity of the Chemokine CCL14	14
Covalent and Noncovalent Targeting of the Tcf4/β-Catenin Strand Interface with β-Hairpin Mimics	14
The Shape of Nanostructures Encodes Immunomodulation of Carbohydrate Antigen and Vaccine Development	14
Nile Red-Based GPCR Ligands as Ultrasensitive Probes of the Local Lipid Microenvironment of the Receptor	14
Cell-surface Labeling via Bioorthogonal Host–Guest Chemistry	14
Chemoproteomic Profiling Reveals the Mechanism of Bile Acid Tolerance in Bacteria	14
Inhibiting HTLV-1 Protease: A Viable Antiviral Target	14
An Integrated Molecular Grafting Approach for the Design of Keap1-Targeted Peptide Inhibitors	14
Pyridazine Nucleobase in Triplex-Forming PNA Improves Recognition of Cytosine Interruptions of Polypurine Tracts in RNA	14
Characterization of an Antibacterial Agent Targeting Ferrous Iron Transport Protein FeoB against Staphylococcus aureus and Gram-Positive Bacteria	14
Activity-Based Diagnostics: Recent Advances in the Development of Probes for Use with Diverse Detection Modalities	14
Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion	13
Proteome-Wide Profiling of Cellular Targets Modified by Dopamine Metabolites Using a Bio-Orthogonally Functionalized Catecholamine	13
Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products	13
A Peptidomimetic Ligand Targeting the Chromodomain of MPP8 Reveals HRP2’s Association with the HUSH Complex	13
A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells	13
OFF-State-Specific Inhibition of the Proprotein Convertase Furin	13
Characterization of a Nanobody-Epitope Tag Interaction and Its Application for Receptor Engineering	13
Identification and Characterization of Bifunctional Drimenol Synthases of Marine Bacterial Origin	13
Identification of Ubiquitin Variants That Inhibit the E2 Ubiquitin Conjugating Enzyme, Ube2k	13
Targeting G-quadruplex Forming Sequences with Cas9	13
Real-Time Monitoring of Human Guanine Deaminase Activity by an Emissive Guanine Analog	13
High-Throughput Enzyme Assay for Screening Inhibitors of the ZDHHC3/7/20 Acyltransferases	13
Triangular in Vivo Self-Assembling Coiled-Coil Protein Origami	13
Biomimetic, Smart, and Multivalent Ligands for G-Quadruplex Isolation and Bioorthogonal Imaging	13
Development of a Broadly Applicable Cas12a-Linked Beam Unlocking Reaction for Sensitive and Specific Detection of Respiratory Pathogens Including SARS-CoV-2	13
Reversible Assembly of Proteolysis Targeting Chimeras	13
Capturing Differences in the Regulation of LRRK2 Dynamics and Conformational States by Small Molecule Kinase Inhibitors	13
Versatile Labeling and Detection of Endogenous Proteins Using Tag-Assisted Split Enzyme Complementation	13
Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD	13
Spatiotemporal Proximity Labeling Tools to Track GlcNAc Sugar-Modified Functional Protein Hubs during Cellular Signaling	13
An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis	13
Microbial Cationic Peptides as a Natural Defense Mechanism against Insect Antimicrobial Peptides	13
Development and Efficacy of an Orally Bioavailable Selective TAK1 Inhibitor for the Treatment of Inflammatory Arthritis	13
Making the Enterobacterial Common Antigen Glycan and Measuring Its Substrate Sequestration	13
Screening of Focused Compound Library Targeting Liver X Receptors in Pancreatic Cancer Identified Ligands with Inverse Agonist and Degrader Activity	13
Active Uptake and Trafficking of Nucleoside Triphosphates In Vivo	13
Complete Chemical Synthesis of Minimal Messenger RNA by Efficient Chemical Capping Reaction	13
Sulfation Code and Conformational Plasticity of l-Iduronic Acid Homo-Oligosaccharides Mimic the Biological Functions of Heparan Sulfate	13
Nucleosome Dynamics during Transcription Elongation	13
An Inherent Difference between Serine and Threonine Phosphorylation: Phosphothreonine Strongly Prefers a Highly Ordered, Compact, Cyclic Conformation	13
Charge Assisted S/Se Chalcogen Bonds in SAM Riboswitches: A Combined PDB and ab Initio Study	13
Dihydrouridine in the Transcriptome: New Life for This Ancient RNA Chemical Modification	13
Structural Insight into the Reaction Mechanism of Ketosynthase-Like Decarboxylase in a Loading Module of Modular Polyketide Synthases	12
Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents	12
Nematode Signaling Molecules Are Extensively Metabolized by Animals, Plants, and Microorganisms	12
Anomeric Fatty Acid Functionalization Prevents Nonenzymatic S-Glycosylation by Monosaccharide Metabolic Chemical Reporters	12
A Metabolic Activation-Based Chemoproteomic Platform to Profile Adducted Proteins Derived from Furan-Containing Compounds	12
Engineering the Sialome	12
Structure Guided Design of Bacteriophage Qβ Mutants as Next Generation Carriers for Conjugate Vaccines	12
Structural Basis for Enzymatic Off-Loading of Hybrid Polyketides by Dieckmann Condensation	12
Bifacial PNAs Destabilize MALAT1 by 3′ A-Tail Displacement from the U-Rich Internal Loop	12
Widespread, Reversible Cysteine Modification by Methylglyoxal Regulates Metabolic Enzyme Function	12
SARS-CoV-2 Spike N-Terminal Domain Engages 9-O-Acetylated α2–8-Linked Sialic Acids	12
Exploring the Surface of the Ectodomain of the PD-L1 Immune Checkpoint with Small-Molecule Fragments	12
Biochemical and Structural Investigation of GnnA in the Lipopolysaccharide Biosynthesis Pathway of Acidithiobacillus ferrooxidans	12
In-Depth Site-Specific O-Glycosylation Analysis of Glycoproteins and Endogenous Peptides in Cerebrospinal Fluid (CSF) from Healthy Individuals, Mild Cognitive Impairment (MCI), and Alzheimer’s Disease	12
Antibacterial Discovery via Phenotypic DNA-Encoded Library Screening	12
Structure and Cooperativity in Substrate–Enzyme Interactions: Perspectives on Enzyme Engineering and Inhibitor Design	12
Discovery of Molecular Glue Degraders via Isogenic Morphological Profiling	12
The Chemical Synthesis of Knob Domain Antibody Fragments	11
Enhancement of Gene Knockdown on CD22-Expressing Cells by Chemically Modified Glycan Ligand–siRNA Conjugates	11
Sialic Acid Derivatives Inhibit SiaT Transporters and Delay Bacterial Growth	11
Heterologous Catalysis of the Final Steps of Tetracycline Biosynthesis by Saccharomyces cerevisiae	11
Serum-Stable and Selective Backbone-N-Methylated Cyclic Peptides That Inhibit Prokaryotic Glycolytic Mutases	11
Combining Rational Design and Continuous Evolution on Minimalist Proteins That Target the E-box DNA Site	11
Region-Specific and Age-Dependent Multitarget Effects of Acetylcholinesterase Inhibitor Tacrine on Comprehensive Neurotransmitter Systems	11
Identification of Gut Bacterial Enzymes for Keto-Reductive Metabolism of Xenobiotics	11
Differential Biosynthesis and Roles of Two Ferrichrome-Type Siderophores, ASP2397/AS2488053 and Ferricrocin, in Acremonium persicinum	11
High-Throughput Cellular Thermal Shift Assay Using Acoustic Transfer of Protein Lysates	11
Chemical Method to Sequence 5-Formylcytosine on RNA	11
Effects of Oncohistone Mutations and PTM Crosstalk on the N-Terminal Acetylation Activities of NatD	11
Parallel Screening Using the Chloroalkane Penetration Assay Reveals Structure-Penetration Relationships	11
Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism	11
Intermolecular Interactions between a Membrane Protein and a Glycolipid Essential for Membrane Protein Integration	11