OOIR: Observatory of International Research

Papers

(The TQCC of ACS Chemical Biology is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Introducing Our Authors	249
Introducing Our Authors	114
Discovery and Validation of a Novel Class of Necroptosis Inhibitors Targeting RIPK1	101
Enzymatic Pathway for Kupyaphore Degradation in Mycobacterium tuberculosis: Mechanism of Metal Homeostasis and Turnover	92
Multi-TACs: Targeting Solid Tumors with Multiple Immune Cell Co-engagers	72
Correction to “Characterization of the Iron–Sulfur Cluster in the NCOA4 Fragment (383–522) and Its Interaction with Ferritin”	68
Visualization of Ectopic Serine Protease Activity by Förster Resonance Energy Transfer-Based Reporters	65
Molecular Targeted Engagement of DPP9 in Rat Tissue Using CETSA, SP3 Processing, and Absolute Quantitation Mass Spectrometry	62
Enzymatic Macrolactamization of mRNA Display Libraries for Inhibitor Selection	52
Targeting IRAK3 for Degradation to Enhance IL-12 Pro-inflammatory Cytokine Production	51
A Robust α-l-Fucosidase from Prevotella nigrescens for Glycoengineering Therapeutic Antibodies	48
Repurposing of the RIPK1-Selective Benzo[1,4]oxazepin-4-one Scaffold for the Development of a Type III LIMK1/2 Inhibitor	48
Mechanistic Studies on Dehydration in Class V Lanthipeptides	47
Exploring Metalloproteome Remodeling in Calprotectin-Stressed Acinetobacter baumannii Using Chemoproteomics	46
A Nonfunctional Halogenase Masquerades as an Aromatizing Dehydratase in Biosynthesis of Pyrrolic Polyketides by Type I Polyketide Synthases	45
Antimicrobial Lasso Peptide Cloacaenodin Utilizes a Unique TonB-Dependent Transporter to Access Susceptible Bacteria	44
Issue Publication Information	43
Issue Editorial Masthead	42
Chemical Synthetic Lethality Screens Identify Selective Drug Combinations against Pseudomonas aeruginosa	42
Biosynthesis of Physcion and Identification of an O-Methyltransferase with C6–OH Selectivity in Aspergillus chevalieri BYST01	41
Robust Chemoenzymatic Synthesis of Keratinimicin Aglycone Analogues Facilitated by the Structure and Selectivity of OxyB	40
Reengineering of Circularly Permuted Caspase-2 to Enhance Enzyme Stability and Enable Crystallographic Studies	40
Dynamic Regulation of 5-Formylcytidine on tRNA	40
In Situ Labeling of Pathogenic Tau Using Photo-Affinity Chemical Probes	39
Target-Responsive DNA Hydrogels with Encapsulation and Release Properties Using Programmable CRISPR-Cas12a	36

Structural and Biochemical Insights into Lignin-Oxidizing Activity of Bacterial Peroxidases against Soluble Substrates and Kraft Lignin	36
An Inherent Difference between Serine and Threonine Phosphorylation: Phosphothreonine Strongly Prefers a Highly Ordered, Compact, Cyclic Conformation	34
Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism	34
HiBiT-SpyTag: A Minimal Tag for Covalent Protein Capture and Degrader Development	34
Simple Enzymatic Incorporation of 2′OMeU Nucleotide at the End of the Poly-A Tail for Enhancement of the mRNA Stability and Protein Expression	34
Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer	33
Structure and Function of the β-Asp-Arg Polymerase Cyanophycin Synthetase 2	33
Spatiotemporal Proximity Labeling Tools to Track GlcNAc Sugar-Modified Functional Protein Hubs during Cellular Signaling	33
Ferroptosis Inhibitors Suppress Prostaglandin Synthesis in Lipopolysaccharide-Stimulated Macrophages	33
Photoactivatable Plant Hormone-Based Chemical Inducers of Proximity for In Vivo Applications	32
ACS Chemical Biology─2022 Editorial Statement	31
Phage Display Selection against a Mixture of Protein Targets	31
Covalent Catalytic Strategies for Enzymes That Modify RNA Molecules on their Tripartite Building Blocks	31
Targeted Discovery of Cryptic Enediyne Natural Products via FRET-Coupled High-Throughput Elicitor Screening	31
Christopher T. Walsh: A Prolific Scientist, Effective Academic Leader, and Responsive Mentor	30
Repurposing the Damage Repair Protein Methyl Guanine Methyl Transferase as a Ligand Inducible Fusion Degron	30
Issue Editorial Masthead	30
Issue Editorial Masthead	29
Issue Publication Information	29
Issue Publication Information	29
Light-Inducible Activation of TrkA for Probing Chronic Pain in Mice	28
Inhibitors of the PqsR Quorum-Sensing Receptor Reveal Differential Roles for PqsE and RhlI in Control of Phenazine Production	28
Small-Molecule FICD Inhibitors Suppress Endogenous and Pathologic FICD-Mediated Protein AMPylation	28
Laboratory Evolution of Metalloid Reductase Substrate Recognition and Nanoparticle Product Size	27
Labeling of CC Chemokine Receptor 2 with a Versatile Intracellular Allosteric Probe	27
Analysis of the Valgamicin Biosynthetic Pathway Reveals a General Mechanism for Cyclopropanol Formation across Diverse Natural Product Scaffolds	27
Split–Combine Click-SELEX Reveals Ligands Recognizing the Transplant Rejection Biomarker CXCL9	27
ATP Regeneration by Polyphosphate Kinase Powers Efficient Oligosaccharide Synthesis Catalyzed by Glycoside Phosphorylases	27
An RNA Methylation-Sensitive AIEgen-Aptamer Reporting System for Quantitatively Evaluating m⁶A Methylase and Demethylase Activities	26
Region-Specific and Age-Dependent Multitarget Effects of Acetylcholinesterase Inhibitor Tacrine on Comprehensive Neurotransmitter Systems	26
Chemical Probes that Target a Dissociative LuxR-Type Quorum Sensing Receptor in Gram-Negative Bacteria	26
2-Cyanopyrimidine-Containing Molecules for N-Terminal Selective Cyclization of Phage-Displayed Peptides	26
Clotrimazole-Based Modulators of the TRPM3 Ion Channel Reveal Narrow Structure–Activity Relationship	26
Exploring Protein S-Palmitoylation: Mechanisms, Detection, and Strategies for Inhibitor Discovery	25
Chemical Genetics in C. elegans Identifies Anticancer Mycotoxins Chaetocin and Chetomin as Potent Inducers of a Nuclear Metal Homeostasis Response	25
C₃-Symmetric Aromatic Core of Griffithsin Is Essential for Potent Anti-HIV Activity	25
Engineering a Low-Immunogenic Mirror-Image VHH against Vascular Endothelial Growth Factor	25
MYC-Targeting PROTACs Lead to Bimodal Degradation and N-Terminal Truncation	25
Design of Class I/IV Bromodomain-Targeting Degraders for Chromatin Remodeling Complexes	25
Issue Editorial Masthead	24
Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization	24
Introducing Our Authors	24
Lanmodulin’s EF 2–3 Domain: Insights from Infrared Spectroscopy and Simulations	24
Issue Editorial Masthead	24
High-Speed Diagnosis of Bacterial Pathogens at the Single Cell Level by Raman Microspectroscopy with Machine Learning Filters and Denoising Autoencoders	24
Bioproduction of a Large-Scale Library of Tryptamine Derivatives for Neuropsychiatric Drug Screening	23
What Is the Crystallographic Resolution of Structural Models of Proteins Generated with AlphaFold2?	23
A Multi-Split-and-Mix Platform for a Variety of Targeted Protein Degradation	23
Tryptamine Metabolism and Functionalization in Gut Commensal Bacteria Expand Human Tryptamine Signaling Responses	23
Tetrazine-Ligated CRISPR sgRNAs for Efficient Genome Editing	23

In Silico Discovery of Group II Intron RNA Splicing Inhibitors	23
Identification of Rapaglutin E as an Isoform-Specific Inhibitor of Glucose Transporter 1	22
Synthesis and Properties of RNA Modified with Cationic Amine Internucleoside Linkage	22
Cyclative Release Strategy to Obtain Pure Cyclic Peptides Directly from the Solid Phase	22
Multiparametric High-Content Cell Painting Identifies Copper Ionophores as Selective Modulators of Esophageal Cancer Phenotypes	22
PPARγ Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles	22
Convergent Alterations of a Protein Hub Produce Divergent Effects within a Binding Site	22
Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective Modulators	22
Native Aminoacyl-tRNA Synthetase/tRNA Pair Drives Highly Efficient Noncanonical Amino Acid Incorporation in Escherichia coli	22
Genome-Guided Discovery of the Myxobacterial Thiolactone-Containing Sorangibactins	22
Bifunctional Sesquiterpene/Diterpene Synthase Agr2 from Cyclocybe aegerita Gives Rise to the Novel Diterpene Cyclocybene	22
Drug-Like Small Molecules That Inhibit Expression of the Oncogenic MicroRNA-21	22
Taxodione Inhibits Glioblastoma Proliferation and Potentiates the Cytotoxicity of Paclitaxel	22
Structures of Methanomethylophilus alvus Pyrrolysine tRNA-Synthetases Support the Need for De Novo Selections When Altering the Substrate Specificity	21
Beyond KRAS(G12C): Biochemical and Computational Characterization of Sotorasib and Adagrasib Binding Specificity and the Critical Role of H95 and Y96	21
A Novel Lysosome Targeting Chimera for Targeted Protein Degradation via Split-and-Mix Strategy	21
Insights into Substrate Recognition by the Unusual Nitrating Enzyme RufO	21
SETDB1 Triple Tudor Domain Ligand, (R,R)-59, Promotes Methylation of Akt1 in Cells	21
Fitness Landscape-Guided Engineering of Locally Supercharged Virus-like Particles with Enhanced Cell Uptake Properties	21
Endogenous ROS-Mediated Covalent Immobilization of Gold Nanoparticles in Mitochondria: A “Sharp Sword” in Tumor Radiotherapy	21
Widespread, Reversible Cysteine Modification by Methylglyoxal Regulates Metabolic Enzyme Function	21
Directed Evolution of PD-L1-Targeted Affibodies by mRNA Display	21
Biosynthesis of the Azoxy Compound Azodyrecin from Streptomyces mirabilis P8-A2	21
Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5	21
Comparative Analysis of Drug-like EP300/CREBBP Acetyltransferase Inhibitors	21
A Plastic Biosynthetic Pathway for the Production of Structurally Distinct Microbial Sunscreens	20
Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct	20
Chemical Therapies for Congenital Disorders of Glycosylation	20
Advances in Optogenetics and Thermogenetics for Control of Non-Neuronal Cells and Tissues in Biomedical Research	20
Optimizing Peptide-Conjugated Lipid Nanoparticles for Efficient siRNA Delivery across the Blood–Brain Barrier and Treatment of Glioblastoma Multiforme	20
Chemical Approaches To Investigate Post-transcriptional RNA Regulation	20
Issue Publication Information	19
Genome Mining of Myxopeptins Reveals a Class of Lanthipeptide-Derived Linear Dehydroamino Acid-Containing Peptides from Myxococcus sp. MCy9171	19
Pathogenic SNPs Affect Both RNA and DNA G-Quadruplexes’ Responses to Ligands	19
Insights into Free Drug Release from Efficacious N-Acyl O-Aminophenol Duocarmycin Prodrugs	19
Multimodal Blood-Based Biomarker Panel Reveals Altered Lysosomal Ionic Content in Alzheimer’s Disease	19
Issue Editorial Masthead	19
Issue Editorial Masthead	19
Development of Comprehensive Screening and Assessment Assays for Small-Molecule Ligands of MALAT1 lncRNA	19
Characterization of Chemical Interactions between Clinical Drugs and the Oral Bacterium, Corynebacterium matruchotii, via Bioactivity-HiTES	19
Discovery of a Compound That Inhibits IRE1α S-Nitrosylation and Preserves the Endoplasmic Reticulum Stress Response under Nitrosative Stress	19
Issue Publication Information	19
Correction to “Analysis of the Sequence Preference of Saporin by Deep Sequencing”	19
In Situ Assembly of Transmembrane Proteins from Expressed and Synthetic Components in Giant Unilamellar Vesicles	19
Biphasic Cellular Response Triggered by Tetrandrine-Mediated Dysfunction and Lysophagic Clearance of Lysosomes	19
Structural, Biochemical, and Bioinformatic Basis for Identifying Radical SAM Cyclopropyl Synthases	18
Metabolic Glycan Labeling in Primary Neurons Enabled by Unnatural Sugars with No S-Glyco-Modification	18
Targeting Gαi/s Proteins with Peptidyl Nucleotide Exchange Modulators	18
The Relationship between Substrate Structure and Selectivity of Ketoreduction in Multimodular Polyketide Synthases: A Comparative Study of A-Type Ketoreductases from Late Modules Using Complex Precurs	18
Chemoproteomic Profiling Reveals the Mechanism of Bile Acid Tolerance in Bacteria	18
In Vivo Metabolic Labeling with an Isoprenoid Probe Reveals APOE Allele-Specific Differences in the Prenylome	18
Phage Selection of Cyclic Peptides Inhibiting Aminoglycoside Phosphotransferases to Control Resistant Bacteria	18
G Protein-Biased Agonists for Intracellular Angiotensin Receptors Promote Collagen Secretion in Myofibroblasts	18
Mapping snoRNA Targets Transcriptome-Wide with snoKARR-seq	18
Screen for Modulation of Nucleocapsid Protein Condensation Identifies Small Molecules with Anti-Coronavirus Activity	17
Site-Specific Introduction of Alanines for the Nuclear Magnetic Resonance Investigation of Low-Complexity Regions and Large Biomolecular Assemblies	17
Stable Isotope-Guided Metabolomics Reveals Polar-Functionalized Fatty-Acylated RiPPs from Streptomyces	17
Blinking Fluorescent Probes for Tubulin Nanoscopy in Living and Fixed Cells	17
Chemical Probe Approach Reveals Endo-α-mannosidase Triages Misfolded Glycoproteins in the Calnexin/Calreticulin Cycle	17
Structure and Function of a Dual Reductase–Dehydratase Enzyme System Involved in p-Terphenyl Biosynthesis	17
Functional Characterization of Structural Genomics Proteins in the Crotonase Superfamily	17
Activity-Based Diagnostics: Recent Advances in the Development of Probes for Use with Diverse Detection Modalities	17
Chemoenzymatic Probes Reveal Peptidoglycan Recognition and Uptake Mechanisms in Candida albicans	17
Drugging the Sarcomere, a Delicate Balance: Position of N-Terminal Charge of the Inhibitor W7	16
Writing and Erasing O-GlcNAc on Casein Kinase 2 Alpha Alters the Phosphoproteome	16
Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity	16
Issue Publication Information	16
Omniligase-1-Mediated Phage-Peptide Library Modification and Insulin Engineering	16
Correction to “A cAMP Sensor Based on Ligand-Dependent Protein Stabilization”	16
Issue Publication Information	16
Mechanistic Analysis of Bioorthogonal Double Strain-Promoted Alkyne–Nitrone Cycloadditions Involving Dibenzocyclooctadiyne	16
Fluorinated Phosphoadenosine 5′-Phosphosulfate Analogues for Continuous Sulfotransferase Activity Monitoring and Inhibitor Screening by ¹⁹F NMR Spectroscopy	16
Modulation of Specialized Metabolite Production in Genetically Engineered Streptomyces pactum	16
Issue Publication Information	16
In-Depth Site-Specific O-Glycosylation Analysis of Glycoproteins and Endogenous Peptides in Cerebrospinal Fluid (CSF) from Healthy Individuals, Mild Cognitive Impairment (MCI), and Alzheimer’s Disease	15
Protein-Labeling Reagents Selectively Activated by Copper(I)	15
Engineering H₂S-Activatable Aptameric Binders for Tailored Cell Manipulation	15
Decoding Protein–Peptide Interactions Using a Large, Target-Agnostic Yeast Surface Display Library	15
Targeted Protein Degradation through Recruitment of the CUL4 Complex Adaptor Protein DDB1	15
A Fluorescence Polarization Assay for Macrodomains Facilitates the Identification of Potent Inhibitors of the SARS-CoV-2 Macrodomain	15

Real-Time Cellular Thermal Shift Assay to Monitor Target Engagement	15
Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an S_Ni Mechanism and Ion Pair Transition State	15
The Impact of Sugar Conformation on the Single-Stranded DNA Selectivity of APOBEC3A and APOBEC3B Enzymes	15
Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity	15
Enhancing the Anticancer Activity of Attenuated Listeria monocytogenes by Cell Wall Functionalization with “Clickable” Doxorubicin	15
Decay of Piwi-Interacting RNAs in Human Cells Is Primarily Mediated by 5′ to 3′ Exoribonucleases	15
Uncovering the Association Mechanism between Two Intrinsically Flexible Proteins	15
Elucidating the Role of the Competence Regulon Quorum Sensing Circuitry in Streptococcus cristatus	15
Borinic Acid-Based Fluorogenic Probes as an Alternative to the Amplex Red Assay for Real-Time H₂O₂ Monitoring in Live Cells	15
Neurotoxic Implications of Human Coronaviruses in Neurodegenerative Diseases: A Perspective from Amyloid Aggregation	15
The HPK1 Inhibitor A-745 Verifies the Potential of Modulating T Cell Kinase Signaling for Immunotherapy	15
Discovery and Mechanism of 16–19F, a Novel Synthetic Lethal Inhibitor of the PRMT5•MTA Complex in MTAP-Deleted Cancer Cells	15
MicroED as a Powerful Tool for Structure Determination of Macrocyclic Drug Compounds Directly from Their Powder Formulations	14
Machine Learning Uncovers Natural Product Modulators of the 5-Lipoxygenase Pathway and Facilitates the Elucidation of Their Biological Mechanisms	14
Correction to “Suppression of DNA Polymerase β Activity is Synthetically Lethal in BRCA1-Deficient Cells”	14
Design, Synthesis, and Mechanistic Studies of (R)-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase	14
Dual-Probe Activity-Based Protein Profiling Reveals Site-Specific Differences in Protein Binding of EGFR-Directed Drugs	14
Adenylation Domain-Guided Recruitment of Trans-Acting Nonheme Monooxygenases in Nonribosomal Peptide Biosynthesis	14
High-Throughput Activity Reprogramming of Proteases (HARP)	14
Regulatory and Catalytic Domains of Poly(ADP-ribose) Polymerases Cross-Complement for DNA-Break-Dependent Allosteric Stimulation of Catalytic Activity	14
A Scavenger Hunt for a DyP-Peroxidase from a Metagenome: Curated Peroxidase Database-Assisted Primer Design and Protein Structure Elucidation	14
Decoding the Mechanism of Specific RNA Targeting by Ribosomal Methyltransferases	14
The Endoplasmic Reticulum-Located TRPV1 Channel Is Not Thermal Sensitive	14
microRNAs Regulate Cellular Magnesium by Tuning Expression of the Plasma Membrane Protein CNNM4	14
Structural Insights and Reaction Profile of a New Unspecific Peroxygenase from Marasmius wettsteinii Produced in a Tandem-Yeast Expression System	14
Structural Insights into Spare-Tire DNA G-Quadruplex from the Human VEGF Promoter	14
Fungal NRPS-PKS Hybrid Enzymes Biosynthesize New γ-Lactam Compounds, Taslactams A-D, Analogous to Actinomycete Proteasome Inhibitors	14
New High-Throughput Screen Discovers Novel Ligands of Full-Length Nuclear Receptor LRH-1	14
Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the Chemokine Receptor CCR2	14
Development and Efficacy of an Orally Bioavailable Selective TAK1 Inhibitor for the Treatment of Inflammatory Arthritis	14
Biosynthesis of Bacillus Phosphonoalamides Reveals Highly Specific Amino Acid Ligation	14
Treatment of Respiratory Distress Syndrome with Single Recombinant Polypeptides that Combine Features of SP-B and SP-C	14
Introducing Our Authors	14
Reversible Antagonism of Dopamine D1 Receptor Using a Photoswitchable Remotely Tethered Ligand	14
Visualizing Intracellular Localization of Natural-Product-Based Chemical Probes Using Click-Correlative Light and Electron Microscopy	14
A Repurposed Drug Interferes with Nucleic Acid to Inhibit the Dual Activities of Coronavirus Nsp13	14
CRISPR RiPCA for Investigating eIF4E-m⁷GpppX Capped mRNA Interactions	14
Identification of Chemical Probes Targeting MBD2	14
Studies Pertaining to the Emerging Cannabinoid Hexahydrocannabinol (HHC)	14
Synthesis of Differentially Halogenated Lissoclimide Analogues To Probe Ribosome E-Site Binding	13
Introducing Our Authors	13
Structure and Biosynthesis of Hectoramide B, a Linear Depsipeptide from Marine Cyanobacterium Moorena producens JHB Discovered via Coculture with Candida albicans	13
Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion	13
Galectin-9 Signaling Drives Breast Cancer Invasion through Extracellular Matrix	13
Selection of Optimal Cell Lines for High-Content Phenotypic Screening	13
Acarbose May Function as a Competitive Exclusion Agent for the Producing Bacteria	13
DNA-Encoded Library Technology─A Catalyst for Covalent Ligand Discovery	13
Rapid Evaluation of Staple Placement in Stabilized α Helices Using Bacterial Surface Display	13
Development of a New DHFR-Based Destabilizing Domain with Enhanced Basal Turnover and Applicability in Mammalian Systems	13
The Base-Editing Enzyme APOBEC3A Catalyzes Cytosine Deamination in RNA with Low Proficiency and High Selectivity	13
Brominated Carbazole with Antibiotic Adjuvant Activity Displays Pleiotropic Effects in MRSA’s Transcriptome	13
Tandem Chemoimmunotherapy by a Cascade-Responsive Molecular Prodrug	13
Novel Substrate Prediction for the TAM Family of RTKs Using Phosphoproteomics and Structure-Based Modeling	13
Discovery of Cyclic Lipopeptides Ralstopeptins A and B from Ralstonia solanacearum Species Complex and Analysis of Biosynthetic Gene Evolution	13
Class IIb Microcin MccM Interferes with Oxidative Phosphorylation in Escherichia coli	13
A Tandem-Affinity Purification Method for Identification of Primary Intracellular Drug-Binding Proteins	13
Phage Display of Two Distinct Warheads to Inhibit Challenging Proteins	13
Dual-Mechanism Confers Self-Resistance to the Antituberculosis Antibiotic Capreomycin	13
Genome-wide CRISPR Screening to Identify Drivers of TGF-β-Induced Liver Fibrosis in Human Hepatic Stellate Cells	13
Switching Prenyl Donor Specificities in Squalene Synthase-Like Aromatic Prenyltransferases from Bacterial Carbazole Alkaloid Biosynthesis	13
Localized Light-Triggered CO Delivery: Comparing the Amount of CO Delivered and Cellular Toxicity	13
Engineered SH2 Domains for Targeted Phosphoproteomics	13
Kinetic and Thermodynamic Insights into Agonist Interactions with the Parathyroid Hormone Receptor-1 from a New NanoBRET Assay	13
Targeting Protein Interaction Hotspots Using Structured and Disordered Chimeric Peptide Inhibitors	13
Cooperative Membrane Damage as a Mechanism for Pentamidine–Antibiotic Mutual Sensitization	13
Cytochrome P450 Mining for Bufadienolide Diversification	13
Issue Publication Information	13
Leveraging Covalency to Stabilize Ternary Complex Formation For Cell–Cell “Induced Proximity”	13
Improved Electrophile Design for Exquisite Covalent Molecule Selectivity	13
General Approach to Identify, Assess, and Characterize Inhibitors of Lipid Peroxidation and Associated Cell Death	13
Introducing Our Authors	12
HSP27 Inhibitory Activity against Caspase-3 Cleavage and Activation by Caspase-9 Is Enhanced by Chaperone O-GlcNAc Modification in Vitro	12
Time-Dependent Studies of Oxaliplatin and Other Nucleolar Stress-Inducing Pt(II) Derivatives	12
Mechanistic Insights into Harmine-Mediated Inhibition of Human DNA Methyltransferases and Prostate Cancer Cell Growth	12
Identification of DDX5 as a Potential Therapeutic Target of Osteosarcoma Using Thiazolone Probes	12
Unraveling the Photoactivation Mechanism of a Light-Activated Adenylyl Cyclase Using Ultrafast Spectroscopy Coupled with Unnatural Amino Acid Mutagenesis	12
Bioinformatic Searching for Optimal RNA Targets of Dimeric Compounds Informs Design of a MicroRNA-27a Inhibitor	12
Small-Molecule Covalent Stabilization and Inhibition of the TEAD·YAP1 Transcription Factor in Cancer Cells	12
Chemical Scaffolds for the Clinical Development of Mutant-Selective and Reversible Fourth-Generation EGFR-TKIs in NSCLC	12
High-Resolution Substrate Specificity Profiling of SARS-CoV-2 M^pro; Comparison to SARS-CoV M^pro	12
Chemoenzymatic Synthesis of Novel Cytotoxic Epoxyketones Using the Eponemycin Biosynthetic Enzyme EpnF	12
Analogs of NIH Molecular Probe ML283 Are Potent SARS-CoV-2 Helicase Inhibitors	12
Metabolic Tracing of Methyl Donor Utilization in Histone Methylation via Relative Quantification of Isotopomer Distribution Mass Spectrometry	12
Select Azo Compounds Post-translationally Modulate HTRA1 Abundance and Activity Potentially through Interactions at the Trimer Interface	12
Bacillus spp. Antibacterial Activity Induced by Triphenyl Tetrazolium Chloride against Ralstonia solanacearum: Oxidative Stress Response and Metabolome Changes	12
Virus Propagation Linked to Exceedingly Rare Gene-Expression Errors: A Single-Molecule Microscopy Demonstration	12
Extrapolating Lessons from Targeted Protein Degradation to Other Proximity-Inducing Drugs	12
Engineered Glycan-Binding Proteins for Recognition of the Thomsen–Friedenreich Antigen and Structurally Related Disaccharides	12
Targeted Degradation of mRNA Decapping Enzyme DcpS by a VHL-Recruiting PROTAC	12
Dynamic Pathway of Guanidine-III Riboswitch Folding Revealed by Single-Molecule FRET: Mg ²⁺ -Assisted Preorganization and Ligand-Induced Kinetic Trap	12
Generating Efficient Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetases for Structurally Diverse Non-Canonical Amino Acids	12
A C-Degron Structure-Based Approach for the Development of Ligands Targeting the E3 Ligase TRIM7	12
Identification of a Selective Pharmacologic IRE1/XBP1s Activator with Enhanced Tissue Exposure	12
Metabolic Investigation and Auxiliary Enzyme Modelization of the Pyrrocidine Pathway Allow Rationalization of Paracyclophane-Decahydrofluorene Formation	12
Origin of the Different Binding Affinities of (9R)- and (9S)-Hexahydrocannabinol (HHC) for the CB₁ and CB₂ Cannabinoid Receptors	12