Nature Chemical Biology

Article	Citations
Sampling the rainbow	297
Modified signals	210
Bringing distant DNA together	196
To protect and emit beauty	169
Say yes to the NOS	163
Peering into the cellular cycle	159
Preserving the barrier	156
Flipping the switch	152
Motif-dependent binding on the intervening domain regulates O-GlcNAc transferase	142
Avoiding arm contact	139
Spatiotemporally controlled generation of NTPs for single-molecule studies	130
Toying with reductive stress	125
Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4	120
Immobilized enzyme cascade for targeted glycosylation	118
Molecular basis of threonine ADP-ribosylation of ubiquitin by bacterial ARTs	118
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer	115
A versatile offense	110
Cyclic signature	104
Protecting with PROTAC	101
Seeing the retention	95
Design of amyloidogenic peptide traps	93
Rationally seeded computational protein design of ɑ-helical barrels	93
Linked to death	90
Your gut on steroids	89
Hunting for human ribozymes	89

Building light-activated synthetic cells that induce gene expression in bacteria via quorum sensing	86
Mining microbial metabolism	86
Metal to the pedal	86
Go with the FLOE	85
Change can be SCARI	83
Drugging viral factories	83
Recording calcium concentrations	82
Identifying p53-independent apoptosis	82
A Wittig combination	81
Chemical targeting of amyloids	79
Cutting the tail	77
CRISP(e)R drug discovery	75
MNK2 deficiency potentiates β-cell regeneration via translational regulation	74
Lysosome-targeting chimeras evolve	73
An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation	73
A viscous switch	72
Development of cyclic peptides that can be administered orally to inhibit disease targets	71
A sulfate amuse-bouche	71
Evolutionary balance between foldability and functionality of a glucose transporter	69
Partitioning of a 2-bit hash function across 66 communicating cells	68
Aiming for the pocket	68
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates	68
Probiotic hat trick	68
Inter-kingdom electromechanical communication	68
Catalysis under stress	68
Anti-aggregate activity	67
Breaking down taurine	67
Cryptic enzymatic assembly of peptides armed with β-lactone warheads	67
The acyl carrier protein dance	66
Proximity-inducing pharmacology	66
Flipping the polarity switch	65
A vicious cycle	65
Choosing the junk	64
Altering the cap	64
Sensing the air	63
Bump-hole ZDHHCs	62
A helical fulcrum in eIF2B coordinates allosteric regulation of stress signaling	61
Bacteria lose a pep in their step	60
Artificial intelligence uncovers carcinogenic human metabolites	60
Monoterpene metabolism unmasked	58
Caught in the act	58
Genes and crystals are not so separate	57
Surviving salt stress	57
Cas1 mediates the interference stage in a phage-encoded CRISPR–Cas system	57
State of play	57
Sensitive fluorescent biosensor reveals differential subcellular regulation of PKC	56
Accelerating enzyme evolution	55
The first step of hypusination	54
Macroscopic quorum sensing sustains differentiating embryonic stem cells	54
Sinking the carrier	54

Sterol homeostasis in yeast	53
Controllable genome editing with split-engineered base editors	53
STACKing the odds for discoveries	53
A structural basis for prion strain diversity	52
Context-based sensing of orthosomycin antibiotics by the translating ribosome	52
A place to dock	51
Ub or not Ub	51
A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance	51
To TnpB or not TnpB? Cas12 is the answer	51
Traffic control	51
In search of chemical rationales	50
The ‘Big Bang’ of the chemical universe	50
Mutanofactin promotes adhesion and biofilm formation of cariogenic Streptococcus mutans	49
Lights on for lipid metabolism	49
Calcium-gated potassium channel blockade via membrane-facing fenestrations	49
Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis	48
Balancing G protein selectivity and efficacy in the adenosine A2A receptor	48
Author Correction: Balancing G protein selectivity and efficacy in the adenosine A2A receptor	48
A new road to STING activation	47
The HaloTag as a general scaffold for far-red tunable chemigenetic indicators	47
The protein universe in 3D	47
Strategies for monitoring cell–cell interactions	47
An RNA aptamer that shifts the reduction potential of metabolic cofactors	47
20 years of Nature Chemical Biology	47
Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1	46
Systematic identification of biomarker-driven drug combinations to overcome resistance	46
Artificial intelligence foundation for therapeutic science	46
Unlocking saponin biosynthesis in soapwort	46
Coaching LSD1 to ignore acetylation	46
CRISPR–dCas12a-mediated genetic circuit cascades for multiplexed pathway optimization	45
A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization	45
Peroxisomal-derived ether phospholipids link nucleotides to respirasome assembly	44
Degradable living plastics programmed by engineered spores	43
A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo	43
Nonmonotone invasion landscape by noise-aware control of metastasis activator levels	42
Long-term super-resolution inner mitochondrial membrane imaging with a lipid probe	42
Endogenous cell membrane interactome mapping for the GLP-1 receptor in different cell types	42
De novo design of buttressed loops for sculpting protein functions	41
Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy	41
An anti-biofilm cyclic peptide targets a secreted aminopeptidase from P. aeruginosa	41
De novo designed peptides for cellular delivery and subcellular localisation	40
Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death	40
Programming cell-surface signaling by phase-separation-controlled compartmentalization	40
An E. coli display method for characterization of peptide–sensor kinase interactions	39
Hydrogel-based biocontainment of bacteria for continuous sensing and computation	39
Programmable living assembly of materials by bacterial adhesion	39
A class of anti-inflammatory lipids decrease with aging in the central nervous system	39
Micropolarity governs the structural organization of biomolecular condensates	39
Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains	39
Targeting lipid–protein interaction to treat Syk-mediated acute myeloid leukemia	38
The role of G protein conformation in receptor–G protein selectivity	38
Structure and mechanism of the methyltransferase ribozyme MTR1	38
Genetic-code-expanded cell-based therapy for treating diabetes in mice	37
A roadmap to creating ferroptosis-based medicines	37
A brief guideline for studies of phase-separated biomolecular condensates	37
Discovery and biosynthesis of cyclic plant peptides via autocatalytic cyclases	37
Programming cell-free biosensors with DNA strand displacement circuits	37
Plasmodesmata mediate cell-to-cell transport of brassinosteroid hormones	36
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability	35
VCP/p97 regulates Beclin-1-dependent autophagy initiation	35
Converting non-neutralizing SARS-CoV-2 antibodies into broad-spectrum inhibitors	35
Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease	35
Enzymatic assembly of the salinosporamide γ-lactam-β-lactone anticancer warhead	35
Biocatalytic cyclization of small macrolactams by a penicillin-binding protein-type thioesterase	34
Author Correction: Structure and mechanism of a methyltransferase ribozyme	34
Discovery of VH domains that allosterically inhibit ENPP1	34
Small molecule probes for targeting autophagy	34
Author Correction: Hypercompact adenine base editors based on a Cas12f variant guided by engineered RNA	34
Structure and mechanism of a methyltransferase ribozyme	33
Addendum: Designing microbial consortia with defined social interactions	33
Author Correction: Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine	33
Publisher Correction: Accelerated RNA detection using tandem CRISPR nucleases	33
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	33
Channeling kynurenine	31
Author Correction: O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology	31
Detecting features of antibody structure through their mediator-accessible redox activities	31
Author Correction: Making a 6mA demethylase	31
Publisher Correction: Rational discovery of molecular glue degraders via scalable chemical profiling	31
Paenilamicins bind to a unique site on the ribosome to inhibit protein synthesis	30
Protein Degradation in Focus	30

Assembly-activated aggregation	30
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms	29
Author Correction: A cytochrome c is the natural electron acceptor for nicotine oxidoreductase	29
Author Correction: Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate	28
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux	28
Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target	28
Combining CRISPRi and metabolomics for functional annotation of compound libraries	28
Making a 6mA demethylase	28
Ancient defensive terpene biosynthetic gene clusters in the soft corals	28
PAFAH2 suppresses synchronized ferroptosis to ameliorate acute kidney injury	28
Chemigenetic indicators based on synthetic chelators and green fluorescent protein	28
Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate	28
Fast and sensitive CRISPR detection by minimized interference of target amplification	27
The landscape of targets and lead molecules for remyelination	27
Adaptive mechanisms of plant specialized metabolism connecting chemistry to function	27
Antibodies expand the scope of angiotensin receptor pharmacology	27
Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1	27
Engineered LwaCas13a with enhanced collateral activity for nucleic acid detection	27
Rapid generation of potent antibodies by autonomous hypermutation in yeast	27
Capturing copper to inhibit inflammation	27
Characterization of a patient-derived variant of GPX4 for precision therapy	27
LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation	27
Quantitative profiling of pseudouridylation landscape in the human transcriptome	27
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor	26
Controlling sulfation	26
Determining the role of peroxidation of subcellular lipid membranes in ferroptosis	26
Scrambling viral infection	26
Seismic shift	25
Changing plates	25
Drivers of intrinsic resistance	25
Overview of chemical biology at the National Natural Science Foundation of China	25
A complex struggle for direction	24
Cyclic nucleotides in for the kill	24
Monitoring lysosomal acidity	24
Peptides hit the catalysis walk	24
Cascading conjugates	24
Shape matching	24
One-site ‘-omics’	24
Metabolism from the magic angle	23
Put another ring on it	23
Nitrosylation rewires metabolism	23
Discovery and molecular basis of subtype-selective cyclophilin inhibitors	23
Amyloid conformation-dependent disaggregation in a reconstituted yeast prion system	23
One-carbon footprint in B cells	23
Evolving complex insulation	22
A chilling effect	22
Adjusting the spikes	22
Translating repair	22
Catch your breath	22
Untying knots with force	22
Mucin tuning	21
Disrupting the phase balance	21
Deep mutational scan of a drug efflux pump reveals its structure–function landscape	21
Compromised autophagy	21
Picking off persisters	21
The enemy of my enemy	21
A molecular shape-shifter	20
TIRs on my pillow	20
A new entry point	20
Molecular conversations	20
Stamp it here	20
Efficiency by location	20
Logic invades cell-free biosensing	20
Modification of cell wall polysaccharide guides cell division in Streptococcus mutans	20
Deform the membrane, cAPTure the lipid	20
Clearing the path	20
Old path, new frontier	20
Brake disposal	20
Small-molecule trapping of an RNA-binding protein blocks cancer cell growth	19
Running through the blocks	19
An antibacterial glove	19
A balancing act	19
Tuned out	19
Lipid metabolism in T cell signaling and function	19
Molecular basis for the selective G protein signaling of somatostatin receptors	19
A gut feeling	19
A genetic platform to investigate the functions of bacterial drug efflux pumps	19
It’s in the blood	19
Chemical biology tools take the strain	18
Endogenous currents in HEK 293 cells are inhibited by memantine	18
Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses	18
Cobalamin in charge	18
No job too small for a giant enzyme	18
Structural insight into selectivity of amylin and calcitonin receptor agonists	18
The many paths ascending to ferroptosis	18
Badminton at nanoscale	18
Open-ended molecular recording of sequential cellular events into DNA	18
Dan Salah Tawfik (1955–2021)	18
The core of the matter	18
DNA-encoded library-enabled discovery of proximity-inducing small molecules	18
Targeting Smurf1 to block PDK1–Akt signaling in KRAS-mutated colorectal cancer	18
Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain	18
A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures	18
Phasing out death	18
A new class of metal-sensing RNA	18