Nature Chemical Biology

Article	Citations
Flipping the polarity switch	296
Altering the cap	255
Sensing the air	230
Cyclic signature	201
Surviving salt stress	178
Making a 6mA demethylase	176
Development of cyclic peptides that can be administered orally to inhibit disease targets	170
Chemical targeting of amyloids	146
Channeling kynurenine	144
To TnpB or not TnpB? Cas12 is the answer	144
A vicious cycle	138
Bacteria lose a pep in their step	136
Assembly-activated aggregation	125
Seeing the retention	122
A pseudoenzyme enables indole biosynthesis in eudicot plants	121
Inter-kingdom electromechanical communication	120
E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells	119
Engineering eukaryotic transposon-encoded Fanzor2 system for genome editing in mammals	118
Programmable living assembly of materials by bacterial adhesion	118
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	117
The landscape of targets and lead molecules for remyelination	110
Detecting features of antibody structure through their mediator-accessible redox activities	108
Facile generation of drug-like conformational antibodies specific for amyloid fibrils	103
Rationally seeded computational protein design of ɑ-helical barrels	102
Artificial intelligence foundation for therapeutic science	99

Calcium-gated potassium channel blockade via membrane-facing fenestrations	98
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux	98
ALFA nanobody-guided endogenous labeling	98
An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation	93
Determining the role of peroxidation of subcellular lipid membranes in ferroptosis	93
Sterol homeostasis in yeast	90
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates	89
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms	89
Chemigenetic indicators based on synthetic chelators and green fluorescent protein	88
Characterization of a patient-derived variant of GPX4 for precision therapy	86
A class of anti-inflammatory lipids decrease with aging in the central nervous system	85
Small-molecule dissolution of stress granules by redox modulation benefits ALS models	85
Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis	85
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability	85
Small-molecule trapping of an RNA-binding protein blocks cancer cell growth	83
Making transient complexes stick	82
Controlling sulfation	82
Seismic shift	82
Oncometabolite 5-IP7 inhibits inositol 5-phosphatase to license E-cadherin endocytosis	81
Visualizing drug effects over time in live animals using optical pharmacodynamics	81
Tuned out	80
Peptides hit the catalysis walk	80
Badminton at nanoscale	79
Running through the blocks	79
Brake disposal	79
M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome	78
Development of an allosteric adhesion GPCR nanobody with therapeutic potential	78
Endogenous currents in HEK 293 cells are inhibited by memantine	77
A wrench in the motor	76
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins	75
Small molecule inhibits KCNQ channels with a non-blocking mechanism	75
A super protein evolution engine	74
Site-specific encoding of photoactivity and photoreactivity into antibody fragments	74
Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells	74
Open-ended molecular recording of sequential cellular events into DNA	74
Programmed RNA editing with an evolved bacterial adenosine deaminase	73
Discovery and molecular basis of subtype-selective cyclophilin inhibitors	71
Functional profiling of serine, threonine and tyrosine sites	71
Small molecule targeting of chromatin writers in cancer	69
Engineering CAR-T cells to activate small-molecule drugs in situ	68
Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II	68
Degrade the RNA	67
SNAP-tag2 for faster and brighter protein labeling	67
Survival of the sweetest tooth	67
An optimized bioluminescent substrate for non-invasive imaging in the brain	67
Protein evolution as a complex system	66
Waking sleeping viruses	66
Medicine from modified mRNA	66
The right angle	65
Lighting up kinase contacts in situ	65

Rolling the RBP snowballs	64
Synthesizing cellular LOGIC	63
RNA-based programmable DNA cleavage	62
A home for orphans	61
NO signal	61
Superbugs leave fingerprints	61
Direct methylation sequencing	57
Affinity for both sides	57
All that glows is gold	57
Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily	56
Lighting up hydrogen peroxide	56
Engineering a xylose fermenting yeast for lignocellulosic ethanol production	55
Hydroxytryptophan biosynthesis by a family of heme-dependent enzymes in bacteria	55
Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection	55
Programmable RNA base editing via targeted modifications	55
Functional targeting of membrane transporters and enzymes to peroxisomes	54
Molecular basis of β-arrestin coupling to the metabotropic glutamate receptor mGlu3	53
Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity	53
Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii	53
ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	53
Single-cell sensor analyses reveal signaling programs enabling Ras-G12C drug resistance	52
Selective bioorthogonal probe for N-glycan hybrid structures	52
Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis	51
Stepwise membrane binding of extended synaptotagmins revealed by optical tweezers	51
Structural basis of efficacy-driven ligand selectivity at GPCRs	51
An unbiased proteomic platform for ATE1-based arginylation profiling	50
Catch in nucleus	49
Pharmacological targeting of BMAL1 modulates circadian and immune pathways	49
Engineering APOBEC3A deaminase for highly accurate and efficient base editing	49
Improving phenotypic screening	49
Direct mapping of tyrosine sulfation states in native peptides by nanopore	49
Providing inclusivity	48
Switching off the stress response	48
Sweet synthetic chaperones	47
A peptide dehydratase with core strength	47
Illuminating GPCR trafficking	47
Author Correction: Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM	47
Prospering phase separation	47
Dissociation for living	47
A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein	46
Anti-infective bile acids bind and inactivate a Salmonella virulence regulator	46
A fat-fueled fatality	46
ALDH2-mediated GABA biosynthesis regulates hippocampal LTP and learning adaptability	45
Signal peptide mimicry primes Sec61 for client-selective inhibition	45
Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1	45
Unfreezing structural biology for drug discovery	45
Chemically engineered antibodies for autophagy-based receptor degradation	44
Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5	44
Genome mining for unknown–unknown natural products	44
Site-selective protein editing by backbone extension acyl rearrangements	43
The β-subunit of tryptophan synthase is a latent tyrosine synthase	43
Modulation of microbial community dynamics by spatial partitioning	43
Publisher Correction: Mutant p53 protein accumulation is selectively targetable by proximity-inducing drugs	43
Phase in phase	43
In-cell kinetic stability is an essential trait in metallo-β-lactamase evolution	42
Inhibition of translation termination by the antimicrobial peptide Drosocin	42
Chemical-based epigenetic reprogramming to advance pluripotency and totipotency	42
Interactions with tau’s microtubule-binding repeats modulate amyloid-β aggregation and toxicity	42
A CRISPR activation screen identifies FBXO22 supporting targeted protein degradation	41
Dynamic basis for dA•dGTP and dA•d8OGTP misincorporation via Hoogsteen base pairs	41
A single-component, light-assisted uncaging switch for endoproteolytic release	41
Alzheimer’s disease–implicated protein tau puts the squeeze on microtubules	40
A rapid chemical reprogramming system to generate human pluripotent stem cells	40
Nanopore glycan profiling	40
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism	40
Chemically inducible split protein regulators for mammalian cells	40
Author Correction: An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity	39
Enzyme assemblies on demand	39
Size matters	39
Capturing receptor states with glue	39
Lighting up DNA	38
Deep dive into a drug pump	38
Expanding beyond the capability of nature	38
Under pressure	38
Rapid discovery of cyclic peptide protein aggregation inhibitors by continuous selection	37
Chemical Decoding of Spatial Biology	37
A tungstopterin-containing enzyme has a key role in microbial ethanol biosynthesis	37
Disarming the pathogen	37
Melting KRAS resistance	36
Publisher Correction: Polyvalent folate receptor-targeting chimeras for degradation of membrane proteins	36

Structural basis of AcrIF24 as an anti-CRISPR protein and transcriptional suppressor	36
A PASS for protein secretion	36
Forced rewiring of RTK signaling	36
Thoughts for the future	36
Hippo pathway regulation by phosphatidylinositol transfer protein and phosphoinositides	35
Lipoyl deglutarylation by ABHD11 regulates mitochondrial and T cell metabolism	35
Imbuing peptide libraries with drug-likeness	35
Bending insulin signals	35
Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36	35
When membrane proteins prefer lipids	35
Spontaneously established syntrophic yeast communities improve bioproduction	35
Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168	35
The realization of CRISPR gene therapy	35
Dissolution of oncofusion transcription factor condensates for cancer therapy	35
A modification-centric assessment tool for the performance of chemoproteomic probes	34
Structural basis of TRPV3 inhibition by an antagonist	34
Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus	34
CRISPR–Cas12a-mediated DNA clamping triggers target-strand cleavage	34
Shackled ribosomes unleashed	34
Convergent evolution of bacterial ceramide synthesis	34
Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands	34
Cross-kingdom warfare	34
An allosteric redox switch involved in oxygen protection in a CO2 reductase	34
Genetically engineered synthetic cells activate cargo release upon temperature shift	33
Redefining the off switch	33
Click, release, destroy	33
Author Correction: Combining CRISPRi and metabolomics for functional annotation of compound libraries	32
Engineering from evolution	32
Moonlighting in the membrane	32
An alternative mechanism for recruiting Cas2/3 in a phage-encoded CRISPR–Cas system	31
Basket of sweets	31
Studying ATP synthesis in situ	31
Evading resistance at the double	31
A Ψ–Ψ codon–anticodon pairing in nonsense suppression and translational recoding	30
Click biology highlights the opportunities from reliable biological reactions	30
Dynamic eIF3a O-GlcNAcylation controls translation reinitiation during nutrient stress	30
A single sensor controls large variations in zinc quotas in a marine cyanobacterium	30
Auxin branches out	30
Enzymatic synthesis of peptide therapeutics	30
Author Correction: A cell-free biosensor signal amplification circuit with polymerase strand recycling	30
Exchange coupling	30
Receptors from an ADAR trick	29
A new class of macrocyclic peptides	29
Chemical editing of proteoglycan architecture	29
Selective targeting of oncogenic hotspot mutations of the HER2 extracellular domain	29
Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma	29
Small-molecule inhibition of the archetypal UbiB protein COQ8	29
TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids	29
Bringing chemistry to medicine to redefine the undruggable	29
Engineered bacterial swarm patterns as spatial records of environmental inputs	29
Programming biological communication between distinct membraneless compartments	29
De novo development of small cyclic peptides that are orally bioavailable	28
In search of chemical rationales	28
Shifting redox reaction equilibria on demand using an orthogonal redox cofactor	28
Unbalanced response to growth variations reshapes the cell fate decision landscape	28
Cutting the tail	28
Enhancing RNA base editing on mammalian transcripts with small nuclear RNAs	28
Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift	28
State of play	28
Recording calcium concentrations	27
In silico prohormone processing	27
Non-heme iron enzymes step into the spotlight	27
Programmable solid-state condensates for spatiotemporal control of mammalian gene expression	27
Combining CRISPRi and metabolomics for functional annotation of compound libraries	27
Mechanism of capsaicin entry into buried vanilloid sites in TRPV1	27
Site-resolved energetic information from HX–MS experiments	27
Aiming for the pocket	27
Design principles imprinted by evolution	27
Traffic control	27
Artificial intelligence uncovers carcinogenic human metabolites	27
Cryptic enzymatic assembly of peptides armed with β-lactone warheads	27
Context-based sensing of orthosomycin antibiotics by the translating ribosome	27
Building light-activated synthetic cells that induce gene expression in bacteria via quorum sensing	27
Learning from CoQ10 history	27
Proximity-inducing pharmacology	27
Capturing copper to inhibit inflammation	27
The protein universe in 3D	27
Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death	27
Partitioning of a 2-bit hash function across 66 communicating cells	26
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor	26
Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R	26
Antibodies expand the scope of angiotensin receptor pharmacology	26
Identifying p53-independent apoptosis	26
Long-term super-resolution inner mitochondrial membrane imaging with a lipid probe	26
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer	26
GA-independent DELLA regulation by inositol pyrophosphate in a nonvascular land plant	26
Expanding the molecular grammar of polar residues and arginine in FUS phase separation	26
Drivers of intrinsic resistance	25
It’s in the blood	25
A new RNA performs old chemistry	25
A gut feeling	25
Stress it up	25
A complex struggle for direction	25
A new twist to increase ion flow	25
One-carbon footprint in B cells	25