Nature Chemical Biology

Article	Citations
Flipping the polarity switch	367
Altering the cap	287
Sensing the air	213
Cyclic signature	193
Development of cyclic peptides that can be administered orally to inhibit disease targets	180
To TnpB or not TnpB? Cas12 is the answer	177
Channeling kynurenine	176
Bacteria lose a pep in their step	161
Seeing the retention	160
Facile generation of drug-like conformational antibodies specific for amyloid fibrils	148
Chemical targeting of amyloids	148
Making a 6mA demethylase	147
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms	147
Sterol homeostasis in yeast	146
Surviving salt stress	143
Assembly-activated aggregation	139
A pseudoenzyme enables indole biosynthesis in eudicot plants	127
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux	126
Chemigenetic indicators based on synthetic chelators and green fluorescent protein	121
E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells	121
Complexoform-specific ligands that modulate the pleiotropic methyltransferase adaptor TRMT112	121
Detecting features of antibody structure through their mediator-accessible redox activities	120
Determining the role of peroxidation of subcellular lipid membranes in ferroptosis	119
ALFA nanobody-guided endogenous labeling	118
The landscape of targets and lead molecules for remyelination	113

Development of the fluorescent probe CenSpark for labeling centrioles and cilia	111
Calcium-gated potassium channel blockade via membrane-facing fenestrations	109
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	109
Engineering eukaryotic transposon-encoded Fanzor2 system for genome editing in mammals	108
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates	107
Small-molecule dissolution of stress granules by redox modulation benefits ALS models	106
A class of anti-inflammatory lipids decrease with aging in the central nervous system	103
Rationally seeded computational protein design of ɑ-helical barrels	102
An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation	99
Inter-kingdom electromechanical communication	98
Artificial intelligence foundation for therapeutic science	94
Rapid evolution of a highly efficient RNA polymerase by homologous recombination	93
Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis	93
Small-molecule trapping of an RNA-binding protein blocks cancer cell growth	92
Seismic shift	89
Controlling sulfation	89
Making transient complexes stick	88
Development of an allosteric adhesion GPCR nanobody with therapeutic potential	87
Peptides hit the catalysis walk	86
Badminton at nanoscale	85
Brake disposal	84
Running through the blocks	84
Discovery and molecular basis of subtype-selective cyclophilin inhibitors	83
Programmed RNA editing with an evolved bacterial adenosine deaminase	83
An optimized bioluminescent substrate for non-invasive imaging in the brain	82
Condensation-independent intramodular translocation mechanism of the trans-AT polyketide synthase assembly line	81
Endogenous currents in HEK 293 cells are inhibited by memantine	79
A super protein evolution engine	78
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins	76
Open-ended molecular recording of sequential cellular events into DNA	75
Site-specific encoding of photoactivity and photoreactivity into antibody fragments	75
Oncometabolite 5-IP7 inhibits inositol 5-phosphatase to license E-cadherin endocytosis	75
Visualizing drug effects over time in live animals using optical pharmacodynamics	74
An evolution-conserved allosteric network in human tubulin governs paclitaxel efficacy	74
Advances in BRET probes for intracellular target engagement studies	73
SNAP-tag2 for faster and brighter protein labeling	71
Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells	71
Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II	70
Small molecule inhibits KCNQ channels with a non-blocking mechanism	70
Survival of the sweetest tooth	66
Functional profiling of serine, threonine and tyrosine sites	66
The right angle	65
Lighting up kinase contacts in situ	65
Synthesizing cellular LOGIC	64
RNA-based programmable DNA cleavage	64
NO signal	63
A home for orphans	62
Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily	62
Affinity for both sides	62
Superbugs leave fingerprints	62

Single-cell sensor analyses reveal signaling programs enabling Ras-G12C drug resistance	61
Molecular basis of β-arrestin coupling to the metabotropic glutamate receptor mGlu3	60
Improving phenotypic screening	59
Medicine from modified mRNA	59
Protein evolution as a complex system	59
Functional targeting of membrane transporters and enzymes to peroxisomes	58
Degrade the RNA	58
Direct methylation sequencing	57
Programmable RNA base editing via targeted modifications	57
ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	56
Lighting up hydrogen peroxide	56
Selective bioorthogonal probe for N-glycan hybrid structures	56
Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity	55
Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection	55
Proteolysis activity mapping and substrate discovery platform for identifying tumor-activated biosensors	55
How Cinchona builds quinine	55
Direct mapping of tyrosine sulfation states in native peptides by nanopore	55
An unbiased proteomic platform for ATE1-based arginylation profiling	54
Hydroxytryptophan biosynthesis by a family of heme-dependent enzymes in bacteria	54
Structural basis of efficacy-driven ligand selectivity at GPCRs	54
Engineering APOBEC3A deaminase for highly accurate and efficient base editing	54
Pharmacological targeting of BMAL1 modulates circadian and immune pathways	53
Engineering a xylose fermenting yeast for lignocellulosic ethanol production	53
Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii	53
Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis	52
Catch in nucleus	52
Providing inclusivity	51
Switching off the stress response	51
Illuminating GPCR trafficking	50
Prospering phase separation	50
Phase in phase	49
Dissociation for living	49
A fat-fueled fatality	49
A peptide dehydratase with core strength	49
Helping sperm keep the beat	48
Site-selective protein editing by backbone extension acyl rearrangements	48
Author Correction: Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM	48
ALDH2-mediated GABA biosynthesis regulates hippocampal LTP and learning adaptability	48
Abasic CRISPR RNAs inherently harness fidelity of SpCas9 for genome editing	47
Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1	47
A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein	47
Chemical-based epigenetic reprogramming to advance pluripotency and totipotency	47
In-cell kinetic stability is an essential trait in metallo-β-lactamase evolution	46
Signal peptide mimicry primes Sec61 for client-selective inhibition	46
A single-component, light-assisted uncaging switch for endoproteolytic release	46
Publisher Correction: Mutant p53 protein accumulation is selectively targetable by proximity-inducing drugs	45
Dynamic basis for dA•dGTP and dA•d8OGTP misincorporation via Hoogsteen base pairs	45
Writing the CRBN degron	45
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism	44
The β-subunit of tryptophan synthase is a latent tyrosine synthase	44
Chemically engineered antibodies for autophagy-based receptor degradation	44
A CRISPR activation screen identifies FBXO22 supporting targeted protein degradation	44
A rapid chemical reprogramming system to generate human pluripotent stem cells	44
Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5	44
Anti-infective bile acids bind and inactivate a Salmonella virulence regulator	44
Genome mining for unknown–unknown natural products	43
Capturing receptor states with glue	43
Interactions with tau’s microtubule-binding repeats modulate amyloid-β aggregation and toxicity	43
Chemically inducible split protein regulators for mammalian cells	43
Inhibition of translation termination by the antimicrobial peptide Drosocin	43
Unfreezing structural biology for drug discovery	43
Lighting up DNA	42
Size matters	42
Deep dive into a drug pump	42
Under pressure	42
Author Correction: An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity	41
Expanding beyond the capability of nature	41
Forced rewiring of RTK signaling	41
Chemical Decoding of Spatial Biology	41
Thoughts for the future	41
Disarming the pathogen	41
The realization of CRISPR gene therapy	40
A PASS for protein secretion	40
A tungstopterin-containing enzyme has a key role in microbial ethanol biosynthesis	40
Melting KRAS resistance	40
Imbuing peptide libraries with drug-likeness	40
When membrane proteins prefer lipids	39
Structural basis of TRPV3 inhibition by an antagonist	39
Structural basis of AcrIF24 as an anti-CRISPR protein and transcriptional suppressor	39
Alzheimer’s disease–implicated protein tau puts the squeeze on microtubules	39

A modification-centric assessment tool for the performance of chemoproteomic probes	38
Lipoyl deglutarylation by ABHD11 regulates mitochondrial and T cell metabolism	38
Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168	38
Bending insulin signals	38
Rapid discovery of cyclic peptide protein aggregation inhibitors by continuous selection	37
Nanopore glycan profiling	37
Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands	36
Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36	36
Publisher Correction: Polyvalent folate receptor-targeting chimeras for degradation of membrane proteins	36
CRISPR–Cas12a-mediated DNA clamping triggers target-strand cleavage	36
Hippo pathway regulation by phosphatidylinositol transfer protein and phosphoinositides	36
Shackled ribosomes unleashed	35
An allosteric redox switch involved in oxygen protection in a CO2 reductase	35
Dissolution of oncofusion transcription factor condensates for cancer therapy	35
Click, release, destroy	35
Spontaneously established syntrophic yeast communities improve bioproduction	35
Moonlighting in the membrane	34
Studying ATP synthesis in situ	34
Redefining the off switch	34
Basket of sweets	34
Genetically engineered synthetic cells activate cargo release upon temperature shift	34
An alternative mechanism for recruiting Cas2/3 in a phage-encoded CRISPR–Cas system	34
Engineering from evolution	34
A single sensor controls large variations in zinc quotas in a marine cyanobacterium	33
Exchange coupling	33
Author Correction: A cell-free biosensor signal amplification circuit with polymerase strand recycling	33
Auxin branches out	33
Enzymatic synthesis of peptide therapeutics	33
Programmable translation	33
Bringing chemistry to medicine to redefine the undruggable	33
Small-molecule inhibition of the archetypal UbiB protein COQ8	32
Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift	32
A new class of macrocyclic peptides	32
Evading resistance at the double	32
Unbalanced response to growth variations reshapes the cell fate decision landscape	32
Programming biological communication between distinct membraneless compartments	32
Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma	32
TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids	32
Structures of ALG3/9/12 reveal the assembly logic of the N-glycan oligomannose core	32
Click biology highlights the opportunities from reliable biological reactions	32
Receptors from an ADAR trick	32
H2O2-free proximity proteomics for exploring dynamic protein complexes in living systems	31
A potent alternative cysteine production pathway allows reductase independence	31
Empowering drug innovation through fundamental RNA research in China	31
Selective targeting of oncogenic hotspot mutations of the HER2 extracellular domain	31
Shifting redox reaction equilibria on demand using an orthogonal redox cofactor	31
Enhancing RNA base editing on mammalian transcripts with small nuclear RNAs	31
Engineered bacterial swarm patterns as spatial records of environmental inputs	31
De novo development of small cyclic peptides that are orally bioavailable	31
A Ψ–Ψ codon–anticodon pairing in nonsense suppression and translational recoding	31
In search of chemical rationales	30
Building light-activated synthetic cells that induce gene expression in bacteria via quorum sensing	30
Friends, foes and signals	30
Proximity-inducing pharmacology	30
State of play	30
Aiming for the pocket	30
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor	30
Antibodies expand the scope of angiotensin receptor pharmacology	30
Challenges and opportunities in RNA-centered therapeutics	30
Traffic control	30
Recording calcium concentrations	30
The protein universe in 3D	30
Learning from CoQ10 history	30
Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death	29
Mechanism of capsaicin entry into buried vanilloid sites in TRPV1	29
Complex-specific inhibitors for interrogating ATAC histone acetyltransferase complex	29
Identifying p53-independent apoptosis	29
Capturing copper to inhibit inflammation	29
Programmable solid-state condensates for spatiotemporal control of mammalian gene expression	29
MEK inhibitors loosen RAF’s grip	29
Non-heme iron enzymes step into the spotlight	29
Site-resolved energetic information from HX–MS experiments	28
Cryptic enzymatic assembly of peptides armed with β-lactone warheads	28
MESH1 functions as a metazoan PAPS phosphatase to regulate sulfation	28
In silico prohormone processing	28
Microtubule depolymerization at kinetochores restricts anaphase spindle elongation	28
Context-based sensing of orthosomycin antibiotics by the translating ribosome	28
GA-independent DELLA regulation by inositol pyrophosphate in a nonvascular land plant	27
A familiar newcomer to the thermogenetic toolset	27
Partitioning of a 2-bit hash function across 66 communicating cells	27
Design principles imprinted by evolution	27
Artificial intelligence uncovers carcinogenic human metabolites	27
Expanding the molecular grammar of polar residues and arginine in FUS phase separation	27
A cold semi-swap	27
Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R	27
Together for RNA breakthroughs	27
Long-term super-resolution inner mitochondrial membrane imaging with a lipid probe	26
One-carbon footprint in B cells	26
RAS signaling gets granular	26
A gut feeling	26
A new twist to increase ion flow	26
Brassinosteroids en route	26
Stress it up	26
Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation	26
MEK interactions tune RAF kinase sensitivity to conformation-selective inhibition	25