Nature Chemical Biology

Article	Citations
Making a 6mA demethylase	212
Chemical targeting of amyloids	208
To TnpB or not TnpB? Cas12 is the answer	185
Channeling kynurenine	183
Detecting features of antibody structure through their mediator-accessible redox activities	177
Cyclic signature	175
A sulfate amuse-bouche	175
Surviving salt stress	156
A vicious cycle	151
Development of cyclic peptides that can be administered orally to inhibit disease targets	151
Flipping the polarity switch	150
Sterol homeostasis in yeast	140
Altering the cap	136
Sensing the air	115
Seeing the retention	113
Assembly-activated aggregation	112
Publisher Correction: Accelerated RNA detection using tandem CRISPR nucleases	107
E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells	106
Bacteria lose a pep in their step	103
Determining the role of peroxidation of subcellular lipid membranes in ferroptosis	102
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms	102
Programmable living assembly of materials by bacterial adhesion	99
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	98
Lysosome-targeting chimeras evolve	97
The landscape of targets and lead molecules for remyelination	97

Small-molecule dissolution of stress granules by redox modulation benefits ALS models	92
Rationally seeded computational protein design of ɑ-helical barrels	90
Characterization of a patient-derived variant of GPX4 for precision therapy	87
Inter-kingdom electromechanical communication	86
Engineering eukaryotic transposon-encoded Fanzor2 system for genome editing in mammals	85
Artificial intelligence foundation for therapeutic science	84
Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis	83
Facile generation of drug-like conformational antibodies specific for amyloid fibrils	82
Chemigenetic indicators based on synthetic chelators and green fluorescent protein	82
Calcium-gated potassium channel blockade via membrane-facing fenestrations	82
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability	81
An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation	81
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates	80
A class of anti-inflammatory lipids decrease with aging in the central nervous system	77
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux	77
Small-molecule trapping of an RNA-binding protein blocks cancer cell growth	76
Seismic shift	76
Running through the blocks	75
The core of the matter	75
Brake disposal	75
Controlling sulfation	75
Small molecule targeting of chromatin writers in cancer	73
Badminton at nanoscale	72
Peptides hit the catalysis walk	71
Making transient complexes stick	70
Programmed RNA editing with an evolved bacterial adenosine deaminase	70
Tuned out	70
Visualizing drug effects over time in live animals using optical pharmacodynamics	69
A wrench in the motor	69
Discovery and molecular basis of subtype-selective cyclophilin inhibitors	68
Small molecule inhibits KCNQ channels with a non-blocking mechanism	68
Development of an allosteric adhesion GPCR nanobody with therapeutic potential	67
Engineering CAR-T cells to activate small-molecule drugs in situ	66
Endogenous currents in HEK 293 cells are inhibited by memantine	66
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins	64
Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells	64
Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II	63
M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome	63
Open-ended molecular recording of sequential cellular events into DNA	62
Escherichia coli small molecule metabolism at the host–microorganism interface	62
Functional profiling of serine, threonine and tyrosine sites	61
Structure-based investigation of fluorogenic Pepper aptamer	59
Site-specific encoding of photoactivity and photoreactivity into antibody fragments	58
An optimized bioluminescent substrate for non-invasive imaging in the brain	58
Survival of the sweetest tooth	57
Medicine from modified mRNA	57
Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily	56
Degrade the RNA	56
Molecular basis of β-arrestin coupling to the metabotropic glutamate receptor mGlu3	56
Superbugs leave fingerprints	56

Selective bioorthogonal probe for N-glycan hybrid structures	55
ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	55
Affinity for both sides	55
Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection	54
Waking sleeping viruses	54
Engineering APOBEC3A deaminase for highly accurate and efficient base editing	54
A home for orphans	54
Structural basis of efficacy-driven ligand selectivity at GPCRs	54
Direct methylation sequencing	53
Single-cell sensor analyses reveal signaling programs enabling Ras-G12C drug resistance	53
RNA-based programmable DNA cleavage	53
Synthesizing cellular LOGIC	53
NO signal	53
Lighting up kinase contacts in situ	52
Rolling the RBP snowballs	52
Hydroxytryptophan biosynthesis by a family of heme-dependent enzymes in bacteria	51
All that glows is gold	51
The right angle	51
Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity	49
Direct mapping of tyrosine sulfation states in native peptides by nanopore	48
Stepwise membrane binding of extended synaptotagmins revealed by optical tweezers	48
Pharmacological targeting of BMAL1 modulates circadian and immune pathways	48
Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis	48
Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii	48
Programmable RNA base editing via targeted modifications	48
Engineering a xylose fermenting yeast for lignocellulosic ethanol production	48
Providing inclusivity	47
Switching off the stress response	47
Sweet synthetic chaperones	46
A peptide dehydratase with core strength	46
Catch in nucleus	46
Author Correction: Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM	46
Illuminating GPCR trafficking	44
Prospering phase separation	44
Inhibition of translation termination by the antimicrobial peptide Drosocin	43
A rapid chemical reprogramming system to generate human pluripotent stem cells	43
Dissociation for living	43
In-cell kinetic stability is an essential trait in metallo-β-lactamase evolution	43
Chemical-based epigenetic reprogramming to advance pluripotency and totipotency	43
The β-subunit of tryptophan synthase is a latent tyrosine synthase	42
A CRISPR activation screen identifies FBXO22 supporting targeted protein degradation	42
Modulation of microbial community dynamics by spatial partitioning	42
A single-component, light-assisted uncaging switch for endoproteolytic release	42
Anti-infective bile acids bind and inactivate a Salmonella virulence regulator	42
Signal peptide mimicry primes Sec61 for client-selective inhibition	41
Chemically inducible split protein regulators for mammalian cells	41
A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein	41
Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1	40
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism	39
Dynamic basis for dA•dGTP and dA•d8OGTP misincorporation via Hoogsteen base pairs	39
CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation	39
Chemically engineered antibodies for autophagy-based receptor degradation	39
Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5	38
Genome mining for unknown–unknown natural products	38
Expanding beyond the capability of nature	37
Nanopore glycan profiling	37
Capturing receptor states with glue	37
Forced rewiring of RTK signaling	37
Deep dive into a drug pump	37
Disarming the pathogen	37
Size matters	37
Author Correction: An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity	37
Enzyme assemblies on demand	37
Alzheimer’s disease–implicated protein tau puts the squeeze on microtubules	37
Under pressure	36
Lighting up DNA	36
A PASS for protein secretion	36
Handling heme with care	36
Structural basis of AcrIF24 as an anti-CRISPR protein and transcriptional suppressor	36
A modification-centric assessment tool for the performance of chemoproteomic probes	35
Imbuing peptide libraries with drug-likeness	35
Convergent evolution of bacterial ceramide synthesis	34
A topological switch in CFTR modulates channel activity and sensitivity to unfolding	34
CRISPR–Cas12a-mediated DNA clamping triggers target-strand cleavage	34
Chemical Decoding of Spatial Biology	34
Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168	34
Rapid discovery of cyclic peptide protein aggregation inhibitors by continuous selection	34
Thoughts for the future	34
Hippo pathway regulation by phosphatidylinositol transfer protein and phosphoinositides	33
Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands	33

Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2	33
An allosteric redox switch involved in oxygen protection in a CO2 reductase	33
Dissolution of oncofusion transcription factor condensates for cancer therapy	33
The realization of CRISPR gene therapy	33
Click, release, destroy	32
Redefining the off switch	32
Spontaneously established syntrophic yeast communities improve bioproduction	32
Cross-kingdom warfare	32
Genetically engineered synthetic cells activate cargo release upon temperature shift	32
Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus	32
Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36	32
Shackled ribosomes unleashed	32
Structural basis of TRPV3 inhibition by an antagonist	32
Basket of sweets	31
Moonlighting in the membrane	31
Bringing chemistry to medicine to redefine the undruggable	31
Engineered bacterial swarm patterns as spatial records of environmental inputs	31
Evading resistance at the double	31
Author Correction: Combining CRISPRi and metabolomics for functional annotation of compound libraries	31
Engineering from evolution	30
An alternative mechanism for recruiting Cas2/3 in a phage-encoded CRISPR–Cas system	30
TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids	30
Programming biological communication between distinct membraneless compartments	30
Studying ATP synthesis in situ	30
Unbalanced response to growth variations reshapes the cell fate decision landscape	30
A new class of macrocyclic peptides	30
Selective targeting of oncogenic hotspot mutations of the HER2 extracellular domain	30
A single sensor controls large variations in zinc quotas in a marine cyanobacterium	29
Chemical editing of proteoglycan architecture	29
Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor	29
De novo development of small cyclic peptides that are orally bioavailable	29
Enzymatic synthesis of peptide therapeutics	29
Dynamic eIF3a O-GlcNAcylation controls translation reinitiation during nutrient stress	29
Author Correction: A cell-free biosensor signal amplification circuit with polymerase strand recycling	29
Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift	29
Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma	29
Small-molecule inhibition of the archetypal UbiB protein COQ8	28
Recording calcium concentrations	28
State of play	28
Shifting redox reaction equilibria on demand using an orthogonal redox cofactor	28
Catalysis under stress	28
Building light-activated synthetic cells that induce gene expression in bacteria via quorum sensing	28
Context-based sensing of orthosomycin antibiotics by the translating ribosome	28
Cutting the tail	28
In search of chemical rationales	28
Traffic control	28
The protein universe in 3D	27
Antibodies expand the scope of angiotensin receptor pharmacology	27
Learning from CoQ10 history	27
Aiming for the pocket	27
In silico prohormone processing	27
Design principles imprinted by evolution	27
Identifying p53-independent apoptosis	27
Partitioning of a 2-bit hash function across 66 communicating cells	27
Proximity-inducing pharmacology	27
Cryptic enzymatic assembly of peptides armed with β-lactone warheads	26
Combining CRISPRi and metabolomics for functional annotation of compound libraries	26
Programmable solid-state condensates for spatiotemporal control of mammalian gene expression	26
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor	26
Long-term super-resolution inner mitochondrial membrane imaging with a lipid probe	26
RAS signaling gets granular	25
Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death	25
Capturing copper to inhibit inflammation	25
It’s in the blood	25
Put another ring on it	25
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer	25
Discovery and biosynthesis of cyclic plant peptides via autocatalytic cyclases	25
A new RNA performs old chemistry	25
Artificial intelligence uncovers carcinogenic human metabolites	25
Expanding the molecular grammar of polar residues and arginine in FUS phase separation	25
Drivers of intrinsic resistance	24
A gut feeling	24
Stress it up	24
A complex struggle for direction	24
Brassinosteroids en route	24
Molecular conversations	24
Amyloid conformation-dependent disaggregation in a reconstituted yeast prion system	24
A new twist to increase ion flow	24
Molecular glue modulates mitochondria	24
How nature ties peptide knots	23
One-carbon footprint in B cells	23
Galectin-13 reduces membrane localization of SLC7A11 for ferroptosis propagation	23
Chemical screening by time-resolved X-ray scattering to discover allosteric probes	23
cIAP1-based degraders induce degradation via branched ubiquitin architectures	23
Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction	23
Old path, new frontier	23
Transcriptional regulation of living materials via extracellular electron transfer	23
The chemical language of protein glycation	23
Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system	23
Protein-based bandpass filters for controlling cellular signaling with chemical inputs	23
Horizontal gene transfer enables programmable gene stability in synthetic microbiota	23
Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals	22
RNA in the spotlight	22
Setting the pace for degrons	22
A long-lived defense	22