Nature Chemical Biology

Article	Citations
Making a 6mA demethylase	259
Chemical targeting of amyloids	237
To TnpB or not TnpB? Cas12 is the answer	204
Channeling kynurenine	202
A sulfate amuse-bouche	199
Cyclic signature	187
Surviving salt stress	174
Development of cyclic peptides that can be administered orally to inhibit disease targets	166
A vicious cycle	162
Flipping the polarity switch	160
Sterol homeostasis in yeast	133
Altering the cap	127
Sensing the air	126
Seeing the retention	121
Assembly-activated aggregation	120
Bacteria lose a pep in their step	113
Determining the role of peroxidation of subcellular lipid membranes in ferroptosis	112
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	109
Facile generation of drug-like conformational antibodies specific for amyloid fibrils	108
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux	107
Engineering eukaryotic transposon-encoded Fanzor2 system for genome editing in mammals	104
Inter-kingdom electromechanical communication	100
E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells	99
Calcium-gated potassium channel blockade via membrane-facing fenestrations	98
A pseudoenzyme enables indole biosynthesis in eudicot plants	97

Programmable living assembly of materials by bacterial adhesion	92
The landscape of targets and lead molecules for remyelination	92
Publisher Correction: Accelerated RNA detection using tandem CRISPR nucleases	91
Small-molecule dissolution of stress granules by redox modulation benefits ALS models	91
Detecting features of antibody structure through their mediator-accessible redox activities	88
Chemigenetic indicators based on synthetic chelators and green fluorescent protein	88
Characterization of a patient-derived variant of GPX4 for precision therapy	87
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates	86
An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation	85
Artificial intelligence foundation for therapeutic science	85
Rationally seeded computational protein design of ɑ-helical barrels	83
ALFA nanobody-guided endogenous labeling	82
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms	82
A class of anti-inflammatory lipids decrease with aging in the central nervous system	82
Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis	81
Seismic shift	79
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability	79
The core of the matter	78
Small-molecule trapping of an RNA-binding protein blocks cancer cell growth	78
Controlling sulfation	77
Running through the blocks	77
Brake disposal	77
Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells	76
Small molecule targeting of chromatin writers in cancer	75
M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome	75
Open-ended molecular recording of sequential cellular events into DNA	74
Functional profiling of serine, threonine and tyrosine sites	74
Development of an allosteric adhesion GPCR nanobody with therapeutic potential	74
Escherichia coli small molecule metabolism at the host–microorganism interface	74
Discovery and molecular basis of subtype-selective cyclophilin inhibitors	73
Structure-based investigation of fluorogenic Pepper aptamer	72
Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II	71
Badminton at nanoscale	70
Peptides hit the catalysis walk	68
Making transient complexes stick	67
Tuned out	67
A wrench in the motor	66
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins	66
Visualizing drug effects over time in live animals using optical pharmacodynamics	65
Small molecule inhibits KCNQ channels with a non-blocking mechanism	64
Engineering CAR-T cells to activate small-molecule drugs in situ	64
Site-specific encoding of photoactivity and photoreactivity into antibody fragments	64
Endogenous currents in HEK 293 cells are inhibited by memantine	64
Oncometabolite 5-IP7 inhibits inositol 5-phosphatase to license E-cadherin endocytosis	63
Programmed RNA editing with an evolved bacterial adenosine deaminase	63
SNAP-tag2 for faster and brighter protein labeling	63
An optimized bioluminescent substrate for non-invasive imaging in the brain	63
Survival of the sweetest tooth	62
Medicine from modified mRNA	61
Degrade the RNA	61

Superbugs leave fingerprints	59
Affinity for both sides	59
A home for orphans	59
Direct methylation sequencing	59
Waking sleeping viruses	58
Synthesizing cellular LOGIC	58
NO signal	57
RNA-based programmable DNA cleavage	57
The right angle	56
Lighting up kinase contacts in situ	56
Rolling the RBP snowballs	56
All that glows is gold	55
Selective bioorthogonal probe for N-glycan hybrid structures	55
Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily	55
Pharmacological targeting of BMAL1 modulates circadian and immune pathways	55
An unbiased proteomic platform for ATE1-based arginylation profiling	54
Engineering APOBEC3A deaminase for highly accurate and efficient base editing	54
Single-cell sensor analyses reveal signaling programs enabling Ras-G12C drug resistance	54
Structural basis of efficacy-driven ligand selectivity at GPCRs	53
Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection	53
Programmable RNA base editing via targeted modifications	53
Protein evolution as a complex system	52
Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis	51
Engineering a xylose fermenting yeast for lignocellulosic ethanol production	51
Stepwise membrane binding of extended synaptotagmins revealed by optical tweezers	50
Direct mapping of tyrosine sulfation states in native peptides by nanopore	50
Functional targeting of membrane transporters and enzymes to peroxisomes	50
Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity	49
Hydroxytryptophan biosynthesis by a family of heme-dependent enzymes in bacteria	49
ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	49
Molecular basis of β-arrestin coupling to the metabotropic glutamate receptor mGlu3	49
Switching off the stress response	48
Sweet synthetic chaperones	48
Providing inclusivity	48
Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii	48
Author Correction: Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM	47
Catch in nucleus	47
A peptide dehydratase with core strength	46
Prospering phase separation	46
Illuminating GPCR trafficking	45
Phase in phase	45
A fat-fueled fatality	45
A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein	45
Anti-infective bile acids bind and inactivate a Salmonella virulence regulator	44
Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1	44
Inhibition of translation termination by the antimicrobial peptide Drosocin	44
Dissociation for living	44
CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation	43
Site-selective protein editing by backbone extension acyl rearrangements	43
Dynamic basis for dA•dGTP and dA•d8OGTP misincorporation via Hoogsteen base pairs	43
In-cell kinetic stability is an essential trait in metallo-β-lactamase evolution	42
A rapid chemical reprogramming system to generate human pluripotent stem cells	42
Interactions with tau’s microtubule-binding repeats modulate amyloid-β aggregation and toxicity	42
ALDH2-mediated GABA biosynthesis regulates hippocampal LTP and learning adaptability	42
Chemically engineered antibodies for autophagy-based receptor degradation	42
Chemical-based epigenetic reprogramming to advance pluripotency and totipotency	42
Genome mining for unknown–unknown natural products	42
Modulation of microbial community dynamics by spatial partitioning	40
The β-subunit of tryptophan synthase is a latent tyrosine synthase	40
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism	39
Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5	39
Signal peptide mimicry primes Sec61 for client-selective inhibition	39
A CRISPR activation screen identifies FBXO22 supporting targeted protein degradation	39
Chemically inducible split protein regulators for mammalian cells	39
Nanopore glycan profiling	39
A single-component, light-assisted uncaging switch for endoproteolytic release	39
Disarming the pathogen	38
Alzheimer’s disease–implicated protein tau puts the squeeze on microtubules	38
Size matters	38
Enzyme assemblies on demand	38
Deep dive into a drug pump	38
Capturing receptor states with glue	38
Author Correction: An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity	38
Lighting up DNA	37
Forced rewiring of RTK signaling	37
Expanding beyond the capability of nature	37
Imbuing peptide libraries with drug-likeness	37
Under pressure	37
Chemical Decoding of Spatial Biology	37
Publisher Correction: Polyvalent folate receptor-targeting chimeras for degradation of membrane proteins	37

An allosteric redox switch involved in oxygen protection in a CO2 reductase	36
A PASS for protein secretion	35
A modification-centric assessment tool for the performance of chemoproteomic probes	35
The realization of CRISPR gene therapy	35
Melting KRAS resistance	35
Thoughts for the future	35
Lipoyl deglutarylation by ABHD11 regulates mitochondrial and T cell metabolism	35
Hippo pathway regulation by phosphatidylinositol transfer protein and phosphoinositides	35
Structural basis of AcrIF24 as an anti-CRISPR protein and transcriptional suppressor	35
Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus	35
CRISPR–Cas12a-mediated DNA clamping triggers target-strand cleavage	35
Structural basis of TRPV3 inhibition by an antagonist	34
Convergent evolution of bacterial ceramide synthesis	34
Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36	34
Rapid discovery of cyclic peptide protein aggregation inhibitors by continuous selection	34
Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands	34
Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2	34
Dissolution of oncofusion transcription factor condensates for cancer therapy	34
Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168	34
Moonlighting in the membrane	33
Genetically engineered synthetic cells activate cargo release upon temperature shift	33
Cross-kingdom warfare	33
Author Correction: Combining CRISPRi and metabolomics for functional annotation of compound libraries	33
Click, release, destroy	33
Evading resistance at the double	33
Spontaneously established syntrophic yeast communities improve bioproduction	33
Redefining the off switch	33
Shackled ribosomes unleashed	33
Basket of sweets	32
Studying ATP synthesis in situ	32
Bringing chemistry to medicine to redefine the undruggable	32
Engineering from evolution	32
A new class of macrocyclic peptides	32
Auxin branches out	31
Author Correction: A cell-free biosensor signal amplification circuit with polymerase strand recycling	31
An alternative mechanism for recruiting Cas2/3 in a phage-encoded CRISPR–Cas system	31
Shifting redox reaction equilibria on demand using an orthogonal redox cofactor	30
Receptors from an ADAR trick	30
Dynamic eIF3a O-GlcNAcylation controls translation reinitiation during nutrient stress	30
TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids	30
Enzymatic synthesis of peptide therapeutics	30
Programming biological communication between distinct membraneless compartments	29
A single sensor controls large variations in zinc quotas in a marine cyanobacterium	29
Selective targeting of oncogenic hotspot mutations of the HER2 extracellular domain	29
Chemical editing of proteoglycan architecture	29
Click biology highlights the opportunities from reliable biological reactions	29
Cutting the tail	28
Small-molecule inhibition of the archetypal UbiB protein COQ8	28
Unbalanced response to growth variations reshapes the cell fate decision landscape	28
De novo development of small cyclic peptides that are orally bioavailable	28
Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma	28
Engineered bacterial swarm patterns as spatial records of environmental inputs	28
Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor	28
Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift	28
Building light-activated synthetic cells that induce gene expression in bacteria via quorum sensing	27
Recording calcium concentrations	27
State of play	27
Context-based sensing of orthosomycin antibiotics by the translating ribosome	27
Traffic control	27
In search of chemical rationales	27
Mechanism of capsaicin entry into buried vanilloid sites in TRPV1	26
Aiming for the pocket	26
Cryptic enzymatic assembly of peptides armed with β-lactone warheads	26
Partitioning of a 2-bit hash function across 66 communicating cells	26
Identifying p53-independent apoptosis	26
The protein universe in 3D	26
In silico prohormone processing	26
Capturing copper to inhibit inflammation	26
GA-independent DELLA regulation by inositol pyrophosphate in a nonvascular land plant	26
Learning from CoQ10 history	26
Catalysis under stress	26
Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death	25
Long-term super-resolution inner mitochondrial membrane imaging with a lipid probe	25
Antibodies expand the scope of angiotensin receptor pharmacology	25
Artificial intelligence uncovers carcinogenic human metabolites	25
Combining CRISPRi and metabolomics for functional annotation of compound libraries	25
Discovery and biosynthesis of cyclic plant peptides via autocatalytic cyclases	25
Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R	25
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer	25
Expanding the molecular grammar of polar residues and arginine in FUS phase separation	25
Non-heme iron enzymes step into the spotlight	25
Proximity-inducing pharmacology	24
It’s in the blood	24
A new twist to increase ion flow	24
Molecular conversations	24
Brassinosteroids en route	24
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor	24
A complex struggle for direction	24
A gut feeling	24
Molecular glue modulates mitochondria	24
Design principles imprinted by evolution	24
A new RNA performs old chemistry	24
Drivers of intrinsic resistance	24
Stress it up	24
One-carbon footprint in B cells	24