Nature Chemical Biology

Article	Citations
Making a 6mA demethylase	219
Chemical targeting of amyloids	199
To TnpB or not TnpB? Cas12 is the answer	192
Channeling kynurenine	182
Detecting features of antibody structure through their mediator-accessible redox activities	179
A sulfate amuse-bouche	174
Cyclic signature	169
Surviving salt stress	168
Development of cyclic peptides that can be administered orally to inhibit disease targets	149
A vicious cycle	146
Flipping the polarity switch	142
Sterol homeostasis in yeast	141
Altering the cap	135
Sensing the air	130
Seeing the retention	114
Assembly-activated aggregation	111
E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells	106
Publisher Correction: Accelerated RNA detection using tandem CRISPR nucleases	106
Bacteria lose a pep in their step	104
Determining the role of peroxidation of subcellular lipid membranes in ferroptosis	101
Calcium-gated potassium channel blockade via membrane-facing fenestrations	101
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms	100
Chemigenetic indicators based on synthetic chelators and green fluorescent protein	98
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux	96
A class of anti-inflammatory lipids decrease with aging in the central nervous system	95

Rationally seeded computational protein design of ɑ-helical barrels	93
An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation	92
Characterization of a patient-derived variant of GPX4 for precision therapy	90
Artificial intelligence foundation for therapeutic science	89
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates	89
The landscape of targets and lead molecules for remyelination	84
Facile generation of drug-like conformational antibodies specific for amyloid fibrils	83
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	83
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability	82
Programmable living assembly of materials by bacterial adhesion	81
Lysosome-targeting chimeras evolve	81
Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis	80
The core of the matter	79
Inter-kingdom electromechanical communication	79
Small-molecule trapping of an RNA-binding protein blocks cancer cell growth	79
Seismic shift	79
Shape matching	78
Brake disposal	77
Controlling sulfation	77
Running through the blocks	75
Site-specific encoding of photoactivity and photoreactivity into antibody fragments	74
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins	73
Badminton at nanoscale	72
An optimized bioluminescent substrate for non-invasive imaging in the brain	72
Peptides hit the catalysis walk	72
Small molecule targeting of chromatin writers in cancer	72
Tuned out	70
Programmed RNA editing with an evolved bacterial adenosine deaminase	69
M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome	69
Engineering CAR-T cells to activate small-molecule drugs in situ	68
A wrench in the motor	67
Making transient complexes stick	67
Discovery and molecular basis of subtype-selective cyclophilin inhibitors	66
Visualizing drug effects over time in live animals using optical pharmacodynamics	66
Functional profiling of serine, threonine and tyrosine sites	66
Endogenous currents in HEK 293 cells are inhibited by memantine	66
Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II	65
Structure-based investigation of fluorogenic Pepper aptamer	65
Small molecule inhibits KCNQ channels with a non-blocking mechanism	65
Open-ended molecular recording of sequential cellular events into DNA	64
Escherichia coli small molecule metabolism at the host–microorganism interface	63
Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells	62
Survival of the sweetest tooth	61
Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo	61
Medicine from modified mRNA	60
Degrade the RNA	60
Engineering a xylose fermenting yeast for lignocellulosic ethanol production	59
Superbugs leave fingerprints	58
Molecular basis of β-arrestin coupling to the metabotropic glutamate receptor mGlu3	58
Hydroxytryptophan biosynthesis by a family of heme-dependent enzymes in bacteria	57

Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily	55
Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity	54
Stepwise membrane binding of extended synaptotagmins revealed by optical tweezers	54
A home for orphans	54
Affinity for both sides	54
Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis	54
Waking sleeping viruses	53
Direct methylation sequencing	53
RNA-based programmable DNA cleavage	52
NO signal	52
Synthesizing cellular LOGIC	52
Single-cell sensor analyses reveal signaling programs enabling Ras-G12C drug resistance	52
Rolling the RBP snowballs	51
Lighting up kinase contacts in situ	51
The right angle	51
Pharmacological targeting of BMAL1 modulates circadian and immune pathways	51
All that glows is gold	51
Structural basis of efficacy-driven ligand selectivity at GPCRs	51
Selective bioorthogonal probe for N-glycan hybrid structures	50
ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	50
Engineering APOBEC3A deaminase for highly accurate and efficient base editing	49
Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii	49
Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection	48
Programmable RNA base editing via targeted modifications	48
Providing inclusivity	47
Switching off the stress response	47
Direct mapping of tyrosine sulfation states in native peptides by nanopore	47
Catch in nucleus	46
Illuminating GPCR trafficking	46
Sweet synthetic chaperones	46
Prospering phase separation	46
Author Correction: Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM	46
A peptide dehydratase with core strength	46
The β-subunit of tryptophan synthase is a latent tyrosine synthase	45
CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation	45
Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1	45
Modulation of microbial community dynamics by spatial partitioning	44
Chemically inducible split protein regulators for mammalian cells	44
Inhibition of translation termination by the antimicrobial peptide Drosocin	43
Signal peptide mimicry primes Sec61 for client-selective inhibition	43
A single-component, light-assisted uncaging switch for endoproteolytic release	42
In-cell kinetic stability is an essential trait in metallo-β-lactamase evolution	42
Dynamic basis for dA•dGTP and dA•d8OGTP misincorporation via Hoogsteen base pairs	42
Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5	41
Anti-infective bile acids bind and inactivate a Salmonella virulence regulator	41
Chemically engineered antibodies for autophagy-based receptor degradation	41
A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein	41
Chemical-based epigenetic reprogramming to advance pluripotency and totipotency	41
Genome mining for unknown–unknown natural products	41
Dissociation for living	41
A CRISPR activation screen identifies FBXO22 supporting targeted protein degradation	40
A rapid chemical reprogramming system to generate human pluripotent stem cells	40
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism	39
Nanopore glycan profiling	38
Alzheimer’s disease–implicated protein tau puts the squeeze on microtubules	37
Size matters	37
Enzyme assemblies on demand	37
Deep dive into a drug pump	37
Disarming the pathogen	37
Capturing receptor states with glue	37
Lighting up DNA	36
Author Correction: An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity	36
Thoughts for the future	36
Handling heme with care	36
Forced rewiring of RTK signaling	36
Under pressure	36
Expanding beyond the capability of nature	36
Structural basis of AcrIF24 as an anti-CRISPR protein and transcriptional suppressor	35
A topological switch in CFTR modulates channel activity and sensitivity to unfolding	35
Architecture of the membrane-bound cytochrome c heme lyase CcmF	35
The realization of CRISPR gene therapy	34
Structural basis of TRPV3 inhibition by an antagonist	34
Dissolution of oncofusion transcription factor condensates for cancer therapy	34
CRISPR–Cas12a-mediated DNA clamping triggers target-strand cleavage	34
Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands	34
A PASS for protein secretion	34
Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36	33
Imbuing peptide libraries with drug-likeness	33
Convergent evolution of bacterial ceramide synthesis	33
Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus	33

A modification-centric assessment tool for the performance of chemoproteomic probes	33
An allosteric redox switch involved in oxygen protection in a CO2 reductase	32
Rapid discovery of cyclic peptide protein aggregation inhibitors by continuous selection	32
Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168	32
Hippo pathway regulation by phosphatidylinositol transfer protein and phosphoinositides	31
Shackled ribosomes unleashed	31
Enzymatic synthesis of peptide therapeutics	31
Genetically engineered synthetic cells activate cargo release upon temperature shift	31
Spontaneously established syntrophic yeast communities improve bioproduction	31
Click, release, destroy	31
Small-molecule inhibition of the archetypal UbiB protein COQ8	31
Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2	31
Cross-kingdom warfare	31
Redefining the off switch	31
Chemical editing of proteoglycan architecture	30
Moonlighting in the membrane	30
Author Correction: Combining CRISPRi and metabolomics for functional annotation of compound libraries	30
Evading resistance at the double	30
A single sensor controls large variations in zinc quotas in a marine cyanobacterium	30
Engineered bacterial swarm patterns as spatial records of environmental inputs	30
Bringing chemistry to medicine to redefine the undruggable	30
A new class of macrocyclic peptides	29
An alternative mechanism for recruiting Cas2/3 in a phage-encoded CRISPR–Cas system	29
Shifting redox reaction equilibria on demand using an orthogonal redox cofactor	29
Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift	29
Studying ATP synthesis in situ	29
Engineering from evolution	29
Basket of sweets	29
Dynamic eIF3a O-GlcNAcylation controls translation reinitiation during nutrient stress	29
Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma	29
Programming biological communication between distinct membraneless compartments	29
Unbalanced response to growth variations reshapes the cell fate decision landscape	29
Selective targeting of oncogenic hotspot mutations of the HER2 extracellular domain	29
Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor	28
De novo development of small cyclic peptides that are orally bioavailable	28
Context-based sensing of orthosomycin antibiotics by the translating ribosome	28
Programmable solid-state condensates for spatiotemporal control of mammalian gene expression	28
Author Correction: A cell-free biosensor signal amplification circuit with polymerase strand recycling	28
Cutting the tail	28
Recording calcium concentrations	28
TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids	28
Catalysis under stress	28
In search of chemical rationales	28
Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death	27
Building light-activated synthetic cells that induce gene expression in bacteria via quorum sensing	27
Aiming for the pocket	27
Proximity-inducing pharmacology	27
Traffic control	27
Learning from CoQ10 history	27
Identifying p53-independent apoptosis	27
State of play	27
The protein universe in 3D	27
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor	26
Combining CRISPRi and metabolomics for functional annotation of compound libraries	26
Capturing copper to inhibit inflammation	26
Cryptic enzymatic assembly of peptides armed with β-lactone warheads	26
Expanding the molecular grammar of polar residues and arginine in FUS phase separation	26
Antibodies expand the scope of angiotensin receptor pharmacology	26
Design principles imprinted by evolution	26
Artificial intelligence uncovers carcinogenic human metabolites	26
Long-term super-resolution inner mitochondrial membrane imaging with a lipid probe	25
Partitioning of a 2-bit hash function across 66 communicating cells	25
Discovery and biosynthesis of cyclic plant peptides via autocatalytic cyclases	25
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer	25
A new RNA performs old chemistry	24
RAS signaling gets granular	24
Amyloid conformation-dependent disaggregation in a reconstituted yeast prion system	24
A new twist to increase ion flow	24
Strategies for monitoring cell–cell interactions	24
In silico prohormone processing	24
Drivers of intrinsic resistance	24
A complex struggle for direction	24
Put another ring on it	24
It’s in the blood	24
Brassinosteroids en route	24
Galectin-13 reduces membrane localization of SLC7A11 for ferroptosis propagation	23
Stress it up	23
How nature ties peptide knots	23
Chemical screening by time-resolved X-ray scattering to discover allosteric probes	23
Molecular conversations	23
Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system	23
One-carbon footprint in B cells	23
A gut feeling	23
Molecular glue modulates mitochondria	23
Transcriptional regulation of living materials via extracellular electron transfer	22
cIAP1-based degraders induce degradation via branched ubiquitin architectures	22
Horizontal gene transfer enables programmable gene stability in synthetic microbiota	22
Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses	22
The chemical language of protein glycation	22
H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity	22
Old path, new frontier	22
Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction	22
Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals	22
Nanobody-based sensors reveal a high proportion of mGlu heterodimers in the brain	21
A chemical solution for FRET(ful) pairs	21