Nature Chemical Biology

Article	Citations
Flipping the polarity switch	389
Cyclic signature	313
Development of cyclic peptides that can be administered orally to inhibit disease targets	219
To TnpB or not TnpB? Cas12 is the answer	192
Channeling kynurenine	192
Bacteria lose a pep in their step	189
Seeing the retention	178
Chemical targeting of amyloids	162
Sterol homeostasis in yeast	159
Surviving salt stress	158
Assembly-activated aggregation	154
Complexoform-specific ligands that modulate the pleiotropic methyltransferase adaptor TRMT112	153
E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells	153
Detecting features of antibody structure through their mediator-accessible redox activities	153
ALFA nanobody-guided endogenous labeling	143
Development of the fluorescent probe CenSpark for labeling centrioles and cilia	142
Rapid evolution of a highly efficient RNA polymerase by homologous recombination	135
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	127
Inter-kingdom electromechanical communication	127
A pseudoenzyme enables indole biosynthesis in eudicot plants	124
Chemigenetic indicators based on synthetic chelators and green fluorescent protein	123
Engineering eukaryotic transposon-encoded Fanzor2 system for genome editing in mammals	120
The landscape of targets and lead molecules for remyelination	119
Determining the role of peroxidation of subcellular lipid membranes in ferroptosis	119
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms	119

Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux	116
Facile generation of drug-like conformational antibodies specific for amyloid fibrils	112
Rationally seeded computational protein design of ɑ-helical barrels	112
Calcium-gated potassium channel blockade via membrane-facing fenestrations	110
A class of anti-inflammatory lipids decrease with aging in the central nervous system	108
Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis	103
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates	100
Small-molecule dissolution of stress granules by redox modulation benefits ALS models	98
Artificial intelligence foundation for therapeutic science	96
Designing fiber–gut microbiome interactions with active learning	94
An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation	94
Seismic shift	93
Small-molecule trapping of an RNA-binding protein blocks cancer cell growth	93
Peptides hit the catalysis walk	92
Controlling sulfation	92
Badminton at nanoscale	91
Brake disposal	88
Running through the blocks	84
Discovery and molecular basis of subtype-selective cyclophilin inhibitors	81
Condensation-independent intramodular translocation mechanism of the trans-AT polyketide synthase assembly line	80
An evolution-conserved allosteric network in human tubulin governs paclitaxel efficacy	80
Endogenous currents in HEK 293 cells are inhibited by memantine	80
Oncometabolite 5-IP7 inhibits inositol 5-phosphatase to license E-cadherin endocytosis	80
A super protein evolution engine	80
Visualizing drug effects over time in live animals using optical pharmacodynamics	79
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins	76
Functional profiling of serine, threonine and tyrosine sites	76
Making transient complexes stick	75
Small molecule inhibits KCNQ channels with a non-blocking mechanism	74
Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II	74
Site-specific encoding of photoactivity and photoreactivity into antibody fragments	72
SNAP-tag2 for faster and brighter protein labeling	70
Programmed RNA editing with an evolved bacterial adenosine deaminase	69
Development of an allosteric adhesion GPCR nanobody with therapeutic potential	69
Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells	68
Open-ended molecular recording of sequential cellular events into DNA	66
Advances in BRET probes for intracellular target engagement studies	66
Survival of the sweetest tooth	65
The right angle	65
An optimized bioluminescent substrate for non-invasive imaging in the brain	65
Lighting up kinase contacts in situ	65
NO signal	64
RNA-based programmable DNA cleavage	64
Synthesizing cellular LOGIC	64
Direct mapping of tyrosine sulfation states in native peptides by nanopore	61
Lighting up hydrogen peroxide	61
Protein evolution as a complex system	61
Selective bioorthogonal probe for N-glycan hybrid structures	61
Single-cell sensor analyses reveal signaling programs enabling Ras-G12C drug resistance	60
Improving phenotypic screening	59

Superbugs leave fingerprints	59
Affinity for both sides	59
Medicine from modified mRNA	58
Degrade the RNA	58
An unbiased proteomic platform for ATE1-based arginylation profiling	57
How Cinchona builds quinine	57
Direct methylation sequencing	57
Functional targeting of membrane transporters and enzymes to peroxisomes	56
Pharmacological targeting of BMAL1 modulates circadian and immune pathways	56
Molecular basis of β-arrestin coupling to the metabotropic glutamate receptor mGlu3	56
Hydroxytryptophan biosynthesis by a family of heme-dependent enzymes in bacteria	56
Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily	56
Proteolysis activity mapping and substrate discovery platform for identifying tumor-activated biosensors	55
Programmable RNA base editing via targeted modifications	55
Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis	55
Engineering APOBEC3A deaminase for highly accurate and efficient base editing	55
ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	53
Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii	53
Engineering a xylose fermenting yeast for lignocellulosic ethanol production	53
Structural basis of efficacy-driven ligand selectivity at GPCRs	52
Catch in nucleus	52
Switching off the stress response	52
Providing inclusivity	51
Prospering phase separation	51
A fat-fueled fatality	50
Illuminating GPCR trafficking	50
A peptide dehydratase with core strength	50
Dissociation for living	50
Author Correction: Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM	49
Phase in phase	49
Anti-infective bile acids bind and inactivate a Salmonella virulence regulator	49
Helping sperm keep the beat	49
ALDH2-mediated GABA biosynthesis regulates hippocampal LTP and learning adaptability	49
Signal peptide mimicry primes Sec61 for client-selective inhibition	48
Publisher Correction: Mutant p53 protein accumulation is selectively targetable by proximity-inducing drugs	48
Abasic CRISPR RNAs inherently harness fidelity of SpCas9 for genome editing	48
Writing the CRBN degron	48
A single-component, light-assisted uncaging switch for endoproteolytic release	47
The β-subunit of tryptophan synthase is a latent tyrosine synthase	47
Chemically engineered antibodies for autophagy-based receptor degradation	47
Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1	46
Site-selective protein editing by backbone extension acyl rearrangements	46
Genome mining for unknown–unknown natural products	46
Chemical-based epigenetic reprogramming to advance pluripotency and totipotency	46
Interactions with tau’s microtubule-binding repeats modulate amyloid-β aggregation and toxicity	46
In-cell kinetic stability is an essential trait in metallo-β-lactamase evolution	46
Inhibition of translation termination by the antimicrobial peptide Drosocin	45
Dynamic basis for dA•dGTP and dA•d8OGTP misincorporation via Hoogsteen base pairs	45
Unfreezing structural biology for drug discovery	45
Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5	45
A rapid chemical reprogramming system to generate human pluripotent stem cells	44
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism	44
A CRISPR activation screen identifies FBXO22 supporting targeted protein degradation	44
Chemically inducible split protein regulators for mammalian cells	43
Capturing receptor states with glue	43
Deep dive into a drug pump	42
Size matters	42
Under pressure	42
Lighting up DNA	42
Author Correction: An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity	41
Expanding beyond the capability of nature	41
Chemical Decoding of Spatial Biology	41
Disarming the pathogen	41
Nanopore glycan profiling	40
Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36	40
Rapid discovery of cyclic peptide protein aggregation inhibitors by continuous selection	40
Forced rewiring of RTK signaling	40
Thoughts for the future	40
Melting KRAS resistance	40
Imbuing peptide libraries with drug-likeness	39
A PASS for protein secretion	39
Alzheimer’s disease–implicated protein tau puts the squeeze on microtubules	39
A tungstopterin-containing enzyme has a key role in microbial ethanol biosynthesis	39
Bending insulin signals	38
The realization of CRISPR gene therapy	38
Publisher Correction: Polyvalent folate receptor-targeting chimeras for degradation of membrane proteins	38
Structural basis of AcrIF24 as an anti-CRISPR protein and transcriptional suppressor	38
Structural basis of TRPV3 inhibition by an antagonist	37
Spontaneously established syntrophic yeast communities improve bioproduction	37
Structural and biochemical basis for cannabinoid cyclase activity in marine bacterial flavoenzymes	37

Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168	37
Designed to bind	37
An allosteric redox switch involved in oxygen protection in a CO2 reductase	37
Achieving cell-type-specific bioorthogonal chemistry using enzyme-activated caged tetrazines	37
Dissolution of oncofusion transcription factor condensates for cancer therapy	37
Lipoyl deglutarylation by ABHD11 regulates mitochondrial and T cell metabolism	37
When membrane proteins prefer lipids	36
Genetically engineered synthetic cells activate cargo release upon temperature shift	36
An alternative mechanism for recruiting Cas2/3 in a phage-encoded CRISPR–Cas system	36
Click, release, destroy	36
Engineering from evolution	36
Studying ATP synthesis in situ	36
Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands	36
Redefining the off switch	36
Basket of sweets	36
Moonlighting in the membrane	36
Exchange coupling	35
Programmable translation	35
Author Correction: A cell-free biosensor signal amplification circuit with polymerase strand recycling	35
Unbalanced response to growth variations reshapes the cell fate decision landscape	35
Auxin branches out	35
Small-molecule inhibition of the archetypal UbiB protein COQ8	35
Bringing chemistry to medicine to redefine the undruggable	35
Evading resistance at the double	34
TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids	34
Selective targeting of oncogenic hotspot mutations of the HER2 extracellular domain	34
Empowering drug innovation through fundamental RNA research in China	34
A potent alternative cysteine production pathway allows reductase independence	34
Click biology highlights the opportunities from reliable biological reactions	34
A new class of macrocyclic peptides	34
Receptors from an ADAR trick	34
Challenges and opportunities in RNA-centered therapeutics	34
A Ψ–Ψ codon–anticodon pairing in nonsense suppression and translational recoding	34
Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma	33
Shifting redox reaction equilibria on demand using an orthogonal redox cofactor	33
Programming biological communication between distinct membraneless compartments	33
Enzymatic synthesis of peptide therapeutics	33
Engineered bacterial swarm patterns as spatial records of environmental inputs	33
Structures of ALG3/9/12 reveal the assembly logic of the N-glycan oligomannose core	32
In search of chemical rationales	32
H2O2-free proximity proteomics for exploring dynamic protein complexes in living systems	32
De novo development of small cyclic peptides that are orally bioavailable	32
Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift	32
Enhancing RNA base editing on mammalian transcripts with small nuclear RNAs	32
How tobacco builds nicotine	32
Non-heme iron enzymes step into the spotlight	31
State of play	31
Proximity-inducing pharmacology	31
Recording calcium concentrations	31
Complex-specific inhibitors for interrogating ATAC histone acetyltransferase complex	31
Building light-activated synthetic cells that induce gene expression in bacteria via quorum sensing	31
Aiming for the pocket	31
MEK inhibitors loosen RAF’s grip	30
In silico prohormone processing	30
A cold semi-swap	30
Identifying p53-independent apoptosis	30
A familiar newcomer to the thermogenetic toolset	30
MESH1 functions as a metazoan PAPS phosphatase to regulate sulfation	30
Capturing copper to inhibit inflammation	30
Microtubule depolymerization at kinetochores restricts anaphase spindle elongation	30
Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death	29
Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R	29
Together for RNA breakthroughs	29
Design principles imprinted by evolution	29
Artificial intelligence uncovers carcinogenic human metabolites	29
The protein universe in 3D	28
Antibodies expand the scope of angiotensin receptor pharmacology	28
Context-based sensing of orthosomycin antibiotics by the translating ribosome	28
Site-resolved energetic information from HX–MS experiments	28
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor	28
Cryptic enzymatic assembly of peptides armed with β-lactone warheads	28
Mechanism of capsaicin entry into buried vanilloid sites in TRPV1	28
Long-term super-resolution inner mitochondrial membrane imaging with a lipid probe	28
Programmable solid-state condensates for spatiotemporal control of mammalian gene expression	28
Learning from CoQ10 history	28
Stress it up	27
Expanding the molecular grammar of polar residues and arginine in FUS phase separation	27
Scaling the protein universe	27
A new twist to increase ion flow	27
One-carbon footprint in B cells	27
Friends, foes and signals	27
A ratiometric fluorescent reporter of mitochondrial sodium	27
A gut feeling	27
GA-independent DELLA regulation by inositol pyrophosphate in a nonvascular land plant	27
Partitioning of a 2-bit hash function across 66 communicating cells	27
Traffic control	27
It’s in the blood	26
RAS signaling gets granular	26
How nature ties peptide knots	26
Noncoded cancer antigens	26
Pseudouridines in translation	26
Molecular glue modulates mitochondria	25
Protein-based bandpass filters for controlling cellular signaling with chemical inputs	25
Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system	25
cIAP1-based degraders induce degradation via branched ubiquitin architectures	25