Nature Chemical Biology

Article	Citations
Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape	404
Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers	343
TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome	280
LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation	216
SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging	211
Rational discovery of molecular glue degraders via scalable chemical profiling	195
Targeted glycan degradation potentiates the anticancer immune response in vivo	192
m6A-binding YTHDF proteins promote stress granule formation	185
Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal	171
Mechanistic dissection of increased enzymatic rate in a phase-separated compartment	149
In vitro prototyping and rapid optimization of biosynthetic enzymes for cell design	138
Structure- and mechanism-guided design of single fluorescent protein-based biosensors	133
A metabolic labeling method detects m6A transcriptome-wide at single base resolution	133
Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2	132
Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products	128
Structural and functional consequences of reversible lipid asymmetry in living membranes	125
Accelerated RNA detection using tandem CRISPR nucleases	125
Antibody-free enzyme-assisted chemical approach for detection of N6-methyladenosine	122
Deubiquitinase-targeting chimeras for targeted protein stabilization	122
Programmed genome editing by a miniature CRISPR-Cas12f nuclease	120
Electric field stimulates production of highly conductive microbial OmcZ nanowires	115
Controlling and enhancing CRISPR systems	109
Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity	108
Hydrogel-based biocontainment of bacteria for continuous sensing and computation	107
A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway	100

Formation and functionalization of membraneless compartments in Escherichia coli	95
Pyruvate-responsive genetic circuits for dynamic control of central metabolism	91
Acoustic biosensors for ultrasound imaging of enzyme activity	91
Cholesterol access in cellular membranes controls Hedgehog signaling	90
Bifunctional small molecules that mediate the degradation of extracellular proteins	90
ROS regulated reversible protein phase separation synchronizes plant flowering	89
Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming	88
Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors	86
The HaloTag as a general scaffold for far-red tunable chemigenetic indicators	86
Living materials fabricated via gradient mineralization of light-inducible biofilms	85
Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation	82
Manumycin polyketides act as molecular glues between UBR7 and P53	81
Functional characterization of a PROTAC directed against BRAF mutant V600E	81
Discovery of a selective inhibitor of doublecortin like kinase 1	80
A community resource for paired genomic and metabolomic data mining	79
Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects	78
The developing toolkit of continuous directed evolution	78
Metabolic engineering strategies to enable microbial utilization of C1 feedstocks	78
Optogenetic control of the lac operon for bacterial chemical and protein production	77
A compendium of kinetic modulatory profiles identifies ferroptosis regulators	77
Rerouting plant terpene biosynthesis enables momilactone pathway elucidation	76
Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy	75
Peroxisome compartmentalization of a toxic enzyme improves alkaloid production	75
Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals	75
Structural basis for diamide modulation of ryanodine receptor	75
Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2	74
Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo	73
PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase	73
Chemically informed analyses of metabolomics mass spectrometry data with Qemistree	70
Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance	70
NADP modulates RNA m6A methylation and adipogenesis via enhancing FTO activity	70
Cell type-selective secretome profiling in vivo	70
Discovery and resistance mechanism of a selective CDK12 degrader	69
YY1 interacts with guanine quadruplexes to regulate DNA looping and gene expression	68
Defining new chemical space for drug penetration into Gram-negative bacteria	67
Designer protein assemblies with tunable phase diagrams in living cells	67
Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast	65
Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease	65
Plant terpenoid metabolism co-opts a component of the cell wall biosynthesis machinery	65
New codons for efficient production of unnatural proteins in a semisynthetic organism	64
Bottom-up de novo design of functional proteins with complex structural features	62
Water-processable, biodegradable and coatable aquaplastic from engineered biofilms	62
Target protein deglycosylation in living cells by a nanobody-fused split O-GlcNAcase	62
Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants	62
Strategies for monitoring cell–cell interactions	60
NMR and EPR reveal a compaction of the RNA-binding protein FUS upon droplet formation	60
Designer membraneless organelles sequester native factors for control of cell behavior	59
Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes	59
Structural insights into probe-dependent positive allosterism of the GLP-1 receptor	58
Organelle membrane-specific chemical labeling and dynamic imaging in living cells	58

Identification of essential sites of lipid peroxidation in ferroptosis	58
Increasing the efficiency and precision of prime editing with guide RNA pairs	58
Phase separation of RNA-binding protein promotes polymerase binding and transcription	58
VCP/p97 regulates Beclin-1-dependent autophagy initiation	58
RNA structure probing uncovers RNA structure-dependent biological functions	57
An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice	57
Learning the chemical grammar of biomolecular condensates	56
Adaptive mechanisms of plant specialized metabolism connecting chemistry to function	56
Programming cell-free biosensors with DNA strand displacement circuits	56
Dissecting the Pol II transcription cycle and derailing cancer with CDK inhibitors	55
Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling	55
Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor	55
Engineering a precise adenine base editor with minimal bystander editing	55
Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii	54
Design of orthogonal regulatory systems for modulating gene expression in plants	54
Rapid generation of potent antibodies by autonomous hypermutation in yeast	53
Comparative tRNA sequencing and RNA mass spectrometry for surveying tRNA modifications	53
Small molecule probes for targeting autophagy	53
Structural dissimilarity from self drives neoepitope escape from immune tolerance	52
Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice	52
Acute pharmacological degradation of Helios destabilizes regulatory T cells	52
An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor	52
PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function	52
Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S)	52
Covalent inhibition of NSD1 histone methyltransferase	52
KRAS is vulnerable to reversible switch-II pocket engagement in cells	51
Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation	51
Robust direct digital-to-biological data storage in living cells	50
ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth	50
Chromatin as a key consumer in the metabolite economy	50
ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells	50
Cuticle thickness affects dynamics of volatile emission from petunia flowers	49
Computation-guided optimization of split protein systems	49
Oncohistone mutations enhance chromatin remodeling and alter cell fates	48
Lipid metabolism in T cell signaling and function	48
Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering	48
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability	48
Targeting androgen receptor phase separation to overcome antiandrogen resistance	47
Structural basis for RING-Cys-Relay E3 ligase activity and its role in axon integrity	46
Orthogonal fluorescent chemogenetic reporters for multicolor imaging	45
The evolution of synthetic receptor systems	44
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer	44
Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism	42
Conformational rearrangement during activation of a metabotropic glutamate receptor	42
Characterization of a patient-derived variant of GPX4 for precision therapy	42
Selective G protein signaling driven by substance P–neurokinin receptor dynamics	41
Repurposing an adenine riboswitch into a fluorogenic imaging and sensing tag	41
Lineage tracing and analog recording in mammalian cells by single-site DNA writing	41
Structural basis for non-radical catalysis by TsrM, a radical SAM methylase	41
K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle	41
Chains of evidence from correlations to causal molecules in microbiome-linked diseases	41
Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel	41
Prospecting for molecular glues	41
Engineering AraC to make it responsive to light instead of arabinose	41
Chemical strategies to overcome resistance against targeted anticancer therapeutics	41
Selective N-glycan editing on living cell surfaces to probe glycoconjugate function	41
Structural basis for selectivity in a highly reducing type II polyketide synthase	41
Systematic discovery of biomolecular condensate-specific protein phosphorylation	40
A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization	40
Engineering CAR-T cells to activate small-molecule drugs in situ	40
G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3	40
Dynamics of an LPS translocon induced by substrate and an antimicrobial peptide	40
Ancient plant-like terpene biosynthesis in corals	40
Visualizing a protonated RNA state that modulates microRNA-21 maturation	39
H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity	39
Detection of cell–cell interactions via photocatalytic cell tagging	39
A brief guideline for studies of phase-separated biomolecular condensates	39
Reversible lysine-targeted probes reveal residence time-based kinase selectivity	39
Insights into distinct signaling profiles of the µOR activated by diverse agonists	38
Ion channels as lipid sensors: from structures to mechanisms	38
Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1	38
Using fungible biosensors to evolve improved alkaloid biosyntheses	37
Programmable living assembly of materials by bacterial adhesion	37
CueR activates transcription through a DNA distortion mechanism	37
Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target	37
Allosteric interactions in the parathyroid hormone GPCR–arrestin complex formation	37
Artificial intelligence foundation for therapeutic science	37
Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine	36
Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders	36
Laboratory evolution of a sortase enzyme that modifies amyloid-β protein	36

Modeling the expansion of virtual screening libraries	36
Identification of a potent and selective covalent Pin1 inhibitor	36
Discovery and biosynthesis of cyclic plant peptides via autocatalytic cyclases	36
A bioluminescent probe for longitudinal monitoring of mitochondrial membrane potential	35
Spectroscopic coherent Raman imaging of Caenorhabditis elegans reveals lipid particle diversity	35
A nucleotide-switch mechanism mediates opposing catalytic activities of Rel enzymes	35
Why succinate? Physiological regulation by a mitochondrial coenzyme Q sentinel	35
Characterizing the portability of phage-encoded homologous recombination proteins	35
Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1	35
Widespread occurrence of covalent lysine–cysteine redox switches in proteins	35
Convergent evolution of bacterial ceramide synthesis	34
Reversal of nucleobase methylation by dioxygenases	34
Targeted degradation via direct 26S proteasome recruitment	34
Activity-based RNA-modifying enzyme probing reveals DUS3L-mediated dihydrouridylation	34
Functional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2	34
Topology-dependent interference of synthetic gene circuit function by growth feedback	33
Molecular basis for arginine C-terminal degron recognition by Cul2FEM1 E3 ligase	33
Ancient defensive terpene biosynthetic gene clusters in the soft corals	33
A new dawn beyond lysine ubiquitination	33
Structural insight into the formation of lipoprotein-β-barrel complexes	33
Production of Tyrian purple indigoid dye from tryptophan in Escherichia coli	33
A bio-inspired cell-free system for cannabinoid production from inexpensive inputs	33
YAP-dependent proliferation by a small molecule targeting annexin A2	32
Cryo-EM structure of the RNA-guided ribonuclease Cas12g	32
Biosynthesis of triacsin featuring an N-hydroxytriazene pharmacophore	32
Permissive epigenomes endow reprogramming competence to transcriptional regulators	32
Engineered LwaCas13a with enhanced collateral activity for nucleic acid detection	32
The conformational cycle of a prototypical voltage-gated sodium channel	32
Use of paramagnetic 19F NMR to monitor domain movement in a glutamate transporter homolog	32
Combining CRISPRi and metabolomics for functional annotation of compound libraries	32
Discovery of small-molecule enzyme activators by activity-based protein profiling	31
Genetically encoded multivalent liquid glycan array displayed on M13 bacteriophage	31
Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain	31
Controllable genome editing with split-engineered base editors	31
A proteome-wide map of 20(S)-hydroxycholesterol interactors in cell membranes	31
Dynamic crotonylation of EB1 by TIP60 ensures accurate spindle positioning in mitosis	31
Structure-based investigation of fluorogenic Pepper aptamer	31
Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains	31
Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth	31
Bright and stable luminescent probes for target engagement profiling in live cells	31
Membrane phase separation drives responsive assembly of receptor signaling domains	31
A mass spectrometry-based proteome map of drug action in lung cancer cell lines	31
Programmable synthetic biomolecular condensates for cellular control	31
Precise genome editing across kingdoms of life using retron-derived DNA	30
Microtubule lattice spacing governs cohesive envelope formation of tau family proteins	30
Prospecting for natural products by genome mining and microcrystal electron diffraction	30
Glucosylation prevents plant defense activation in phloem-feeding insects	30
CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation	30
Drug antagonism and single-agent dominance result from differences in death kinetics	30
Engineering orthogonal human O-linked glycoprotein biosynthesis in bacteria	30
Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis	30
Imaging and targeting LOX-mediated tissue remodeling with a reactive collagen peptide	29
Spatial decoding of endosomal cAMP signals by a metastable cytoplasmic PKA network	29
Molecular and environmental determinants of biomolecular condensate formation	29
Enzymatic C–H activation of aromatic compounds through CO2 fixation	29
O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1	29
Mechanical strength of RNA knot in Zika virus protects against cellular defenses	29
p63 uses a switch-like mechanism to set the threshold for induction of apoptosis	29
Identifying cell receptors for the nanoparticle protein corona using genome screens	28
Active turnover of genomic methylcytosine in pluripotent cells	28
Site-specific ubiquitination affects protein energetics and proteasomal degradation	28
Tools, tactics and objectives to interrogate cellular roles of O-GlcNAc in disease	28
Synthetic protein condensates for cellular and metabolic engineering	27
Modulation of auxin formation by the cytosolic phenylalanine biosynthetic pathway	27
Molecular basis for ubiquitin ligase CRL2FEM1C-mediated recognition of C-degron	26
A quantitative method for proteome reallocation using minimal regulatory interventions	26
Structures of the human cholecystokinin receptors bound to agonists and antagonists	26
Peroxisomal-derived ether phospholipids link nucleotides to respirasome assembly	26
Reaction pathway engineering converts a radical hydroxylase into a halogenase	26
Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection	25
Quantitative profiling of pseudouridylation landscape in the human transcriptome	25
Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler	25
A roadmap to creating ferroptosis-based medicines	25
Host and microbiota metabolic signals in aging and longevity	24
Multiplexed GTPase and GEF biosensor imaging enables network connectivity analysis	24
Structures and function of the amino acid polymerase cyanophycin synthetase	24
Harnessing nanotechnology to expand the toolbox of chemical biology	24
CRISPR–dCas12a-mediated genetic circuit cascades for multiplexed pathway optimization	24
Structural basis for persulfide-sensing specificity in a transcriptional regulator	24
The importance of the membrane for biophysical measurements	24
Peroxiredoxins couple metabolism and cell division in an ultradian cycle	24
Pyridoxal-5′-phosphate-dependent alkyl transfer in nucleoside antibiotic biosynthesis	24
Structural and functional diversity among agonist-bound states of the GLP-1 receptor	24
HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain	24
Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity	24
Hovlinc is a recently evolved class of ribozyme found in human lncRNA	24
Mutanofactin promotes adhesion and biofilm formation of cariogenic Streptococcus mutans	24
Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus	23
Engineering site-selective incorporation of fluorine into polyketides	23
Modulation of microbial community dynamics by spatial partitioning	23
Selective regulation of human TRAAK channels by biologically active phospholipids	23
Organoid screening reveals epigenetic vulnerabilities in human colorectal cancer	23
Genome mining for unknown–unknown natural products	23
Single-cell multi-omics in the medicinal plant Catharanthus roseus	22
An optimized bioluminescent substrate for non-invasive imaging in the brain	22