Nature Chemical Biology

Article	Citations
LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation	265
Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal	199
Mechanistic dissection of increased enzymatic rate in a phase-separated compartment	182
Structure- and mechanism-guided design of single fluorescent protein-based biosensors	154
Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2	152
Programmed genome editing by a miniature CRISPR-Cas12f nuclease	151
Deubiquitinase-targeting chimeras for targeted protein stabilization	149
Accelerated RNA detection using tandem CRISPR nucleases	147
Structural and functional consequences of reversible lipid asymmetry in living membranes	143
Hydrogel-based biocontainment of bacteria for continuous sensing and computation	139
Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity	134
Controlling and enhancing CRISPR systems	123
Identification of essential sites of lipid peroxidation in ferroptosis	116
ROS regulated reversible protein phase separation synchronizes plant flowering	113
Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation	113
Bifunctional small molecules that mediate the degradation of extracellular proteins	106
Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii	104
The HaloTag as a general scaffold for far-red tunable chemigenetic indicators	104
Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals	100
Living materials fabricated via gradient mineralization of light-inducible biofilms	99
Cholesterol access in cellular membranes controls Hedgehog signaling	98
Metabolic engineering strategies to enable microbial utilization of C1 feedstocks	98
Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast	95
Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo	91
Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy	89

A compendium of kinetic modulatory profiles identifies ferroptosis regulators	86
A community resource for paired genomic and metabolomic data mining	86
Lipid metabolism in T cell signaling and function	85
Engineering a precise adenine base editor with minimal bystander editing	84
Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance	83
YY1 interacts with guanine quadruplexes to regulate DNA looping and gene expression	83
Learning the chemical grammar of biomolecular condensates	81
Cell type-selective secretome profiling in vivo	81
Defining new chemical space for drug penetration into Gram-negative bacteria	79
Discovery and resistance mechanism of a selective CDK12 degrader	78
Strategies for monitoring cell–cell interactions	78
Designer membraneless organelles sequester native factors for control of cell behavior	77
Programming cell-free biosensors with DNA strand displacement circuits	76
Water-processable, biodegradable and coatable aquaplastic from engineered biofilms	76
VCP/p97 regulates Beclin-1-dependent autophagy initiation	76
Chemically informed analyses of metabolomics mass spectrometry data with Qemistree	76
Adaptive mechanisms of plant specialized metabolism connecting chemistry to function	75
Bottom-up de novo design of functional proteins with complex structural features	73
Phase separation of RNA-binding protein promotes polymerase binding and transcription	72
Target protein deglycosylation in living cells by a nanobody-fused split O-GlcNAcase	72
Increasing the efficiency and precision of prime editing with guide RNA pairs	70
Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S)	70
Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes	69
RNA structure probing uncovers RNA structure-dependent biological functions	68
NMR and EPR reveal a compaction of the RNA-binding protein FUS upon droplet formation	68
Small molecule probes for targeting autophagy	67
Acute pharmacological degradation of Helios destabilizes regulatory T cells	67
ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth	67
Rapid generation of potent antibodies by autonomous hypermutation in yeast	66
Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease	66
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer	66
Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor	65
Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants	65
Membrane phase separation drives responsive assembly of receptor signaling domains	64
Targeting androgen receptor phase separation to overcome antiandrogen resistance	62
Oncohistone mutations enhance chromatin remodeling and alter cell fates	62
Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation	62
A brief guideline for studies of phase-separated biomolecular condensates	61
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability	61
Robust direct digital-to-biological data storage in living cells	60
Insights into distinct signaling profiles of the µOR activated by diverse agonists	58
H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity	58
Detection of cell–cell interactions via photocatalytic cell tagging	57
The evolution of synthetic receptor systems	57
Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering	57
KRAS is vulnerable to reversible switch-II pocket engagement in cells	57
Repurposing an adenine riboswitch into a fluorogenic imaging and sensing tag	55
Modeling the expansion of virtual screening libraries	55
Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1	54
Computation-guided optimization of split protein systems	54

Artificial intelligence foundation for therapeutic science	54
A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization	53
Selective G protein signaling driven by substance P–neurokinin receptor dynamics	53
Systematic discovery of biomolecular condensate-specific protein phosphorylation	52
Chains of evidence from correlations to causal molecules in microbiome-linked diseases	51
Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1	51
Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism	51
Ancient plant-like terpene biosynthesis in corals	51
Single-cell multi-omics in the medicinal plant Catharanthus roseus	51
Characterization of a patient-derived variant of GPX4 for precision therapy	51
Programmable synthetic biomolecular condensates for cellular control	51
Lineage tracing and analog recording in mammalian cells by single-site DNA writing	50
Molecular and environmental determinants of biomolecular condensate formation	49
Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders	49
Ion channels as lipid sensors: from structures to mechanisms	49
Conformational rearrangement during activation of a metabotropic glutamate receptor	48
K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle	48
Why succinate? Physiological regulation by a mitochondrial coenzyme Q sentinel	48
Reversible lysine-targeted probes reveal residence time-based kinase selectivity	48
Dynamics of an LPS translocon induced by substrate and an antimicrobial peptide	47
Engineered LwaCas13a with enhanced collateral activity for nucleic acid detection	47
Widespread occurrence of covalent lysine–cysteine redox switches in proteins	47
A new dawn beyond lysine ubiquitination	47
Programmable living assembly of materials by bacterial adhesion	47
Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine	47
Synthetic protein condensates for cellular and metabolic engineering	47
Structural basis for non-radical catalysis by TsrM, a radical SAM methylase	46
Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target	46
Engineering AraC to make it responsive to light instead of arabinose	46
Precise genome editing across kingdoms of life using retron-derived DNA	46
Functional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2	46
Structure-based investigation of fluorogenic Pepper aptamer	45
O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1	45
Engineering CAR-T cells to activate small-molecule drugs in situ	45
Genome mining for unknown–unknown natural products	44
Using fungible biosensors to evolve improved alkaloid biosyntheses	44
Activity-based RNA-modifying enzyme probing reveals DUS3L-mediated dihydrouridylation	44
Quantitative profiling of pseudouridylation landscape in the human transcriptome	43
Convergent evolution of bacterial ceramide synthesis	43
Dynamic crotonylation of EB1 by TIP60 ensures accurate spindle positioning in mitosis	43
Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis	42
Discovery and biosynthesis of cyclic plant peptides via autocatalytic cyclases	42
Laboratory evolution of a sortase enzyme that modifies amyloid-β protein	42
Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth	42
Targeted degradation via direct 26S proteasome recruitment	42
Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains	41
The conformational cycle of a prototypical voltage-gated sodium channel	41
Ancient defensive terpene biosynthetic gene clusters in the soft corals	41
Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain	41
Prospecting for natural products by genome mining and microcrystal electron diffraction	40
CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation	39
Imaging and targeting LOX-mediated tissue remodeling with a reactive collagen peptide	39
Characterizing the portability of phage-encoded homologous recombination proteins	39
Production of Tyrian purple indigoid dye from tryptophan in Escherichia coli	39
Bright and stable luminescent probes for target engagement profiling in live cells	39
Reaction pathway engineering converts a radical hydroxylase into a halogenase	38
YAP-dependent proliferation by a small molecule targeting annexin A2	38
Genetically encoded multivalent liquid glycan array displayed on M13 bacteriophage	37
Molecular basis for arginine C-terminal degron recognition by Cul2FEM1 E3 ligase	37
A proteome-wide map of 20(S)-hydroxycholesterol interactors in cell membranes	37
Biosynthesis of triacsin featuring an N-hydroxytriazene pharmacophore	36
Combining CRISPRi and metabolomics for functional annotation of compound libraries	36
Cryo-EM structure of the RNA-guided ribonuclease Cas12g	35
Modulation of microbial community dynamics by spatial partitioning	35
Identifying cell receptors for the nanoparticle protein corona using genome screens	35
Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection	35
Structures of the human cholecystokinin receptors bound to agonists and antagonists	34
Controllable genome editing with split-engineered base editors	34
Hovlinc is a recently evolved class of ribozyme found in human lncRNA	34
HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain	34
Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity	34
Microtubule lattice spacing governs cohesive envelope formation of tau family proteins	33
Engineering site-selective incorporation of fluorine into polyketides	33
Host and microbiota metabolic signals in aging and longevity	33
Tools, tactics and objectives to interrogate cellular roles of O-GlcNAc in disease	33
Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus	33
Mechanical strength of RNA knot in Zika virus protects against cellular defenses	32
Hypercompact adenine base editors based on a Cas12f variant guided by engineered RNA	31
Mutanofactin promotes adhesion and biofilm formation of cariogenic Streptococcus mutans	31
Organoid screening reveals epigenetic vulnerabilities in human colorectal cancer	31

Spatial decoding of endosomal cAMP signals by a metastable cytoplasmic PKA network	31
A roadmap to creating ferroptosis-based medicines	31
Complex regulation in a Comamonas platform for diverse aromatic carbon metabolism	31
Peroxisomal-derived ether phospholipids link nucleotides to respirasome assembly	31
3-Mercaptopyruvate sulfur transferase is a protein persulfidase	30
A structural basis for prion strain diversity	30
Cell-type-specific labeling and profiling of glycans in living mice	30
CRISPR–dCas12a-mediated genetic circuit cascades for multiplexed pathway optimization	30
Structural and functional diversity among agonist-bound states of the GLP-1 receptor	29
An optimized bioluminescent substrate for non-invasive imaging in the brain	29
Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1	28
Harnessing nanotechnology to expand the toolbox of chemical biology	28
GCN2 kinase activation by ATP-competitive kinase inhibitors	28
A general method for the development of multicolor biosensors with large dynamic ranges	28
Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis	28
An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity	28
Peroxiredoxins couple metabolism and cell division in an ultradian cycle	28
Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler	28
TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids	27
Nanosensor-based monitoring of autophagy-associated lysosomal acidification in vivo	27
The role of G protein conformation in receptor–G protein selectivity	27
Metabolism of a hybrid algal galactan by members of the human gut microbiome	27
Remodeling oncogenic transcriptomes by small molecules targeting NONO	27
Temperature-responsive optogenetic probes of cell signaling	27
Molecular basis for ubiquitin ligase CRL2FEM1C-mediated recognition of C-degron	27
Structures and function of the amino acid polymerase cyanophycin synthetase	27
Modification of cell wall polysaccharide guides cell division in Streptococcus mutans	26
A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo	26
The importance of the membrane for biophysical measurements	25
Stepwise membrane binding of extended synaptotagmins revealed by optical tweezers	25
Functional metagenomic screening identifies an unexpected β-glucuronidase	25
Hippo pathway regulation by phosphatidylinositol transfer protein and phosphoinositides	24
Biosynthesis of saponin defensive compounds in sea cucumbers	24
A common mechanism of Sec61 translocon inhibition by small molecules	24
Ligand recognition and allosteric modulation of the human MRGPRX1 receptor	24
Nanobody-based sensors reveal a high proportion of mGlu heterodimers in the brain	24
Base editor scanning charts the DNMT3A activity landscape	24
Single-molecule imaging of glycan–lectin interactions on cells with Glyco-PAINT	24
Small molecule targeting of chromatin writers in cancer	24
Functional elucidation of TfuA in peptide backbone thioamidation	23
Monitoring Fe–S cluster occupancy across the E. coli proteome using chemoproteomics	23
Enzymatic assembly of the salinosporamide γ-lactam-β-lactone anticancer warhead	23
Allostery governs Cdk2 activation and differential recognition of CDK inhibitors	23
Genetic-code-expanded cell-based therapy for treating diabetes in mice	23
Enzymology of assembly line synthesis by modular polyketide synthases	23
Probing coenzyme A homeostasis with semisynthetic biosensors	23
Structure and mechanism of a methyltransferase ribozyme	23
Anti-infective bile acids bind and inactivate a Salmonella virulence regulator	22
De novo designed peptides for cellular delivery and subcellular localisation	22
Complete biosynthesis of the potent vaccine adjuvant QS-21	22
Correlative metabologenomics of 110 fungi reveals metabolite–gene cluster pairs	22
Structure and mechanism of the methyltransferase ribozyme MTR1	22
CRISPR–Cas12a-mediated DNA clamping triggers target-strand cleavage	22
M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome	22
A bacterial sulfoglycosidase highlights mucin O-glycan breakdown in the gut ecosystem	21
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor	21
Symmetric and asymmetric receptor conformation continuum induced by a new insulin	21
Structural basis of efficacy-driven ligand selectivity at GPCRs	21
Predictable control of RNA lifetime using engineered degradation-tuning RNAs	21
Bicyclostreptins are radical SAM enzyme-modified peptides with unique cyclization motifs	21
Genetically encoded tools for measuring and manipulating metabolism	21
Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction	21
A repackaged CRISPR platform increases homology-directed repair for yeast engineering	21
Yeast- and antibody-based tools for studying tryptophan C-mannosylation	21
Apoptolidin family glycomacrolides target leukemia through inhibition of ATP synthase	20
Amyloid conformation-dependent disaggregation in a reconstituted yeast prion system	20
Dissolution of oncofusion transcription factor condensates for cancer therapy	20
Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota	20
Plasmodesmata mediate cell-to-cell transport of brassinosteroid hormones	20
A topological switch in CFTR modulates channel activity and sensitivity to unfolding	20
Structure of UBE2K–Ub/E3/polyUb reveals mechanisms of K48-linked Ub chain extension	20
Na+ riboswitches regulate genes for diverse physiological processes in bacteria	19
Chemoproteomic identification of CO2-dependent lysine carboxylation in proteins	19
Molecular mechanism underlying substrate recognition of the peptide macrocyclase PsnB	19
Horizontal gene transfer enables programmable gene stability in synthetic microbiota	19
Spatial transcriptome uncovers rich coordination of metabolism in E. coli K12 biofilm	19
A genetic platform to investigate the functions of bacterial drug efflux pumps	19
Structural basis of TRPV3 inhibition by an antagonist	18
Cardiac contraction and relaxation are regulated by distinct subcellular cAMP pools	18
Assigning functionality to cysteines by base editing of cancer dependency genes	18
Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid dehydrogenases	18
MNK2 deficiency potentiates β-cell regeneration via translational regulation	18
Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1	18
Spontaneously established syntrophic yeast communities improve bioproduction	18
Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5	18
The fluorescent aptamer Squash extensively repurposes the adenine riboswitch fold	18
Engineering co-utilization of glucose and xylose for chemical overproduction from lignocellulose	18
A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures	18
Post-translational insertion of boron in proteins to probe and modulate function	18
Synthetic anaplerotic modules for the direct synthesis of complex molecules from CO2	18
Chemical detection triggers honey bee defense against a destructive parasitic threat	18
Polarized focal adhesion kinase activity within a focal adhesion during cell migration	18
Scalable biological signal recording in mammalian cells using Cas12a base editors	18
Deep mutational scan of a drug efflux pump reveals its structure–function landscape	18
Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands	18