Nature Chemical Biology

Article	Citations
Making a 6mA demethylase	244
Chemical targeting of amyloids	223
Channeling kynurenine	197
To TnpB or not TnpB? Cas12 is the answer	197
Detecting features of antibody structure through their mediator-accessible redox activities	194
A sulfate amuse-bouche	188
Cyclic signature	181
Surviving salt stress	167
Development of cyclic peptides that can be administered orally to inhibit disease targets	159
A vicious cycle	158
Flipping the polarity switch	157
Sterol homeostasis in yeast	156
Altering the cap	131
Sensing the air	123
Seeing the retention	122
Assembly-activated aggregation	116
Publisher Correction: Accelerated RNA detection using tandem CRISPR nucleases	116
Bacteria lose a pep in their step	111
An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation	110
Determining the role of peroxidation of subcellular lipid membranes in ferroptosis	108
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	107
Facile generation of drug-like conformational antibodies specific for amyloid fibrils	106
Rationally seeded computational protein design of ɑ-helical barrels	104
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux	102
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability	98

Characterization of a patient-derived variant of GPX4 for precision therapy	97
Engineering eukaryotic transposon-encoded Fanzor2 system for genome editing in mammals	93
Lysosome-targeting chimeras evolve	93
Inter-kingdom electromechanical communication	91
E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells	89
Calcium-gated potassium channel blockade via membrane-facing fenestrations	88
Artificial intelligence foundation for therapeutic science	88
A pseudoenzyme enables indole biosynthesis in eudicot plants	88
Small-molecule dissolution of stress granules by redox modulation benefits ALS models	86
Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis	85
A class of anti-inflammatory lipids decrease with aging in the central nervous system	83
The landscape of targets and lead molecules for remyelination	83
Programmable living assembly of materials by bacterial adhesion	82
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates	81
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms	81
Seismic shift	80
Chemigenetic indicators based on synthetic chelators and green fluorescent protein	80
Small-molecule trapping of an RNA-binding protein blocks cancer cell growth	79
The core of the matter	78
Controlling sulfation	77
Brake disposal	76
Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells	75
Running through the blocks	75
M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome	75
Small molecule targeting of chromatin writers in cancer	74
Functional profiling of serine, threonine and tyrosine sites	73
Escherichia coli small molecule metabolism at the host–microorganism interface	73
Peptides hit the catalysis walk	72
Tuned out	72
Badminton at nanoscale	72
Making transient complexes stick	71
A wrench in the motor	70
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins	69
Endogenous currents in HEK 293 cells are inhibited by memantine	67
Engineering CAR-T cells to activate small-molecule drugs in situ	67
Development of an allosteric adhesion GPCR nanobody with therapeutic potential	67
Small molecule inhibits KCNQ channels with a non-blocking mechanism	67
Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II	64
Discovery and molecular basis of subtype-selective cyclophilin inhibitors	64
Structure-based investigation of fluorogenic Pepper aptamer	63
Programmed RNA editing with an evolved bacterial adenosine deaminase	63
Site-specific encoding of photoactivity and photoreactivity into antibody fragments	62
Open-ended molecular recording of sequential cellular events into DNA	62
SNAP-tag2 for faster and brighter protein labeling	62
An optimized bioluminescent substrate for non-invasive imaging in the brain	60
Visualizing drug effects over time in live animals using optical pharmacodynamics	59
Affinity for both sides	59
Medicine from modified mRNA	59
Degrade the RNA	59
Survival of the sweetest tooth	59

Superbugs leave fingerprints	59
A home for orphans	58
Synthesizing cellular LOGIC	58
Waking sleeping viruses	58
RNA-based programmable DNA cleavage	57
Rolling the RBP snowballs	57
NO signal	57
Lighting up kinase contacts in situ	56
The right angle	56
Engineering a xylose fermenting yeast for lignocellulosic ethanol production	55
All that glows is gold	55
Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily	54
Hydroxytryptophan biosynthesis by a family of heme-dependent enzymes in bacteria	54
Functional targeting of membrane transporters and enzymes to peroxisomes	54
ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	54
Selective bioorthogonal probe for N-glycan hybrid structures	54
Pharmacological targeting of BMAL1 modulates circadian and immune pathways	53
Single-cell sensor analyses reveal signaling programs enabling Ras-G12C drug resistance	52
Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity	52
Structural basis of efficacy-driven ligand selectivity at GPCRs	51
Engineering APOBEC3A deaminase for highly accurate and efficient base editing	51
Programmable RNA base editing via targeted modifications	50
Molecular basis of β-arrestin coupling to the metabotropic glutamate receptor mGlu3	50
Direct methylation sequencing	50
Direct mapping of tyrosine sulfation states in native peptides by nanopore	49
Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection	49
Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis	49
Switching off the stress response	48
Stepwise membrane binding of extended synaptotagmins revealed by optical tweezers	48
Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii	48
Providing inclusivity	47
Sweet synthetic chaperones	46
Author Correction: Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM	45
Catch in nucleus	45
Prospering phase separation	44
Illuminating GPCR trafficking	44
A peptide dehydratase with core strength	44
A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein	44
Chemically inducible split protein regulators for mammalian cells	44
Dynamic basis for dA•dGTP and dA•d8OGTP misincorporation via Hoogsteen base pairs	44
Phase in phase	43
A single-component, light-assisted uncaging switch for endoproteolytic release	43
A fat-fueled fatality	43
CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation	43
A rapid chemical reprogramming system to generate human pluripotent stem cells	42
Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1	42
Dissociation for living	42
Inhibition of translation termination by the antimicrobial peptide Drosocin	42
In-cell kinetic stability is an essential trait in metallo-β-lactamase evolution	42
Signal peptide mimicry primes Sec61 for client-selective inhibition	42
Chemical-based epigenetic reprogramming to advance pluripotency and totipotency	42
Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5	41
Anti-infective bile acids bind and inactivate a Salmonella virulence regulator	41
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism	40
Chemically engineered antibodies for autophagy-based receptor degradation	40
Genome mining for unknown–unknown natural products	40
Modulation of microbial community dynamics by spatial partitioning	39
The β-subunit of tryptophan synthase is a latent tyrosine synthase	39
A CRISPR activation screen identifies FBXO22 supporting targeted protein degradation	39
Alzheimer’s disease–implicated protein tau puts the squeeze on microtubules	38
Enzyme assemblies on demand	38
Nanopore glycan profiling	38
Size matters	38
Disarming the pathogen	38
Capturing receptor states with glue	38
Convergent evolution of bacterial ceramide synthesis	37
Lighting up DNA	37
Deep dive into a drug pump	37
Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2	37
Expanding beyond the capability of nature	37
Under pressure	37
Author Correction: An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity	37
Hippo pathway regulation by phosphatidylinositol transfer protein and phosphoinositides	36
Forced rewiring of RTK signaling	36
Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36	36
Rapid discovery of cyclic peptide protein aggregation inhibitors by continuous selection	36
CRISPR–Cas12a-mediated DNA clamping triggers target-strand cleavage	36
Publisher Correction: Polyvalent folate receptor-targeting chimeras for degradation of membrane proteins	36
The realization of CRISPR gene therapy	35
Structural basis of AcrIF24 as an anti-CRISPR protein and transcriptional suppressor	35

Chemical Decoding of Spatial Biology	35
Lipoyl deglutarylation by ABHD11 regulates mitochondrial and T cell metabolism	35
Spontaneously established syntrophic yeast communities improve bioproduction	35
A topological switch in CFTR modulates channel activity and sensitivity to unfolding	35
A PASS for protein secretion	35
Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168	35
Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus	34
Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands	34
Imbuing peptide libraries with drug-likeness	34
Structural basis of TRPV3 inhibition by an antagonist	34
A modification-centric assessment tool for the performance of chemoproteomic probes	34
Dissolution of oncofusion transcription factor condensates for cancer therapy	34
An allosteric redox switch involved in oxygen protection in a CO2 reductase	34
Thoughts for the future	34
Shackled ribosomes unleashed	33
Genetically engineered synthetic cells activate cargo release upon temperature shift	33
Cross-kingdom warfare	33
Click, release, destroy	33
Basket of sweets	32
Author Correction: Combining CRISPRi and metabolomics for functional annotation of compound libraries	32
A new class of macrocyclic peptides	32
Engineering from evolution	32
Moonlighting in the membrane	32
Bringing chemistry to medicine to redefine the undruggable	32
Redefining the off switch	32
Evading resistance at the double	32
Small-molecule inhibition of the archetypal UbiB protein COQ8	31
Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift	31
Click biology highlights the opportunities from reliable biological reactions	31
An alternative mechanism for recruiting Cas2/3 in a phage-encoded CRISPR–Cas system	31
Studying ATP synthesis in situ	31
Selective targeting of oncogenic hotspot mutations of the HER2 extracellular domain	31
Unbalanced response to growth variations reshapes the cell fate decision landscape	30
Enzymatic synthesis of peptide therapeutics	30
Auxin branches out	30
Programming biological communication between distinct membraneless compartments	30
A single sensor controls large variations in zinc quotas in a marine cyanobacterium	30
Chemical editing of proteoglycan architecture	30
Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor	30
TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids	30
Author Correction: A cell-free biosensor signal amplification circuit with polymerase strand recycling	30
Dynamic eIF3a O-GlcNAcylation controls translation reinitiation during nutrient stress	30
Engineered bacterial swarm patterns as spatial records of environmental inputs	30
Shifting redox reaction equilibria on demand using an orthogonal redox cofactor	29
De novo development of small cyclic peptides that are orally bioavailable	28
State of play	28
Context-based sensing of orthosomycin antibiotics by the translating ribosome	28
Receptors from an ADAR trick	28
Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma	28
In search of chemical rationales	28
Cutting the tail	28
Building light-activated synthetic cells that induce gene expression in bacteria via quorum sensing	28
Recording calcium concentrations	28
Identifying p53-independent apoptosis	27
Programmable solid-state condensates for spatiotemporal control of mammalian gene expression	27
Traffic control	27
Aiming for the pocket	27
The protein universe in 3D	27
Learning from CoQ10 history	27
Capturing copper to inhibit inflammation	26
Proximity-inducing pharmacology	26
Design principles imprinted by evolution	26
Combining CRISPRi and metabolomics for functional annotation of compound libraries	26
In silico prohormone processing	26
Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R	26
Partitioning of a 2-bit hash function across 66 communicating cells	26
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor	25
Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death	25
Long-term super-resolution inner mitochondrial membrane imaging with a lipid probe	25
Catalysis under stress	25
Expanding the molecular grammar of polar residues and arginine in FUS phase separation	25
Discovery and biosynthesis of cyclic plant peptides via autocatalytic cyclases	25
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer	25
Artificial intelligence uncovers carcinogenic human metabolites	25
Mechanism of capsaicin entry into buried vanilloid sites in TRPV1	25
GA-independent DELLA regulation by inositol pyrophosphate in a nonvascular land plant	25
Cryptic enzymatic assembly of peptides armed with β-lactone warheads	25
Brassinosteroids en route	24
Put another ring on it	24
A complex struggle for direction	24
A gut feeling	24
A new RNA performs old chemistry	24
Drivers of intrinsic resistance	24
Stress it up	24
Antibodies expand the scope of angiotensin receptor pharmacology	24
It’s in the blood	24
A new twist to increase ion flow	24
Chemical screening by time-resolved X-ray scattering to discover allosteric probes	23
Galectin-13 reduces membrane localization of SLC7A11 for ferroptosis propagation	23
Protein-based bandpass filters for controlling cellular signaling with chemical inputs	23
Molecular conversations	23
Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system	23
Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation	23
Pharmacological inhibition of PSPH reduces serine levels and epileptic seizures	23
Horizontal gene transfer enables programmable gene stability in synthetic microbiota	23