Nature Chemical Biology

Article	Citations
Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape	397
Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers	328
TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome	276
Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles	224
LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation	205
SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging	205
Rational discovery of molecular glue degraders via scalable chemical profiling	192
Targeted glycan degradation potentiates the anticancer immune response in vivo	188
m6A-binding YTHDF proteins promote stress granule formation	178
Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal	167
Mechanistic dissection of increased enzymatic rate in a phase-separated compartment	144
In vitro prototyping and rapid optimization of biosynthetic enzymes for cell design	137
Structure- and mechanism-guided design of single fluorescent protein-based biosensors	131
A metabolic labeling method detects m6A transcriptome-wide at single base resolution	130
Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2	127
Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products	125
Accelerated RNA detection using tandem CRISPR nucleases	123
Unifying principles of bifunctional, proximity-inducing small molecules	122
Deubiquitinase-targeting chimeras for targeted protein stabilization	120
Antibody-free enzyme-assisted chemical approach for detection of N6-methyladenosine	119
Structural and functional consequences of reversible lipid asymmetry in living membranes	118
Programmed genome editing by a miniature CRISPR-Cas12f nuclease	116
Electric field stimulates production of highly conductive microbial OmcZ nanowires	111
Hydrogel-based biocontainment of bacteria for continuous sensing and computation	107
Controlling and enhancing CRISPR systems	104

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity	103
A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway	98
Pyruvate-responsive genetic circuits for dynamic control of central metabolism	89
Formation and functionalization of membraneless compartments in Escherichia coli	89
Cholesterol access in cellular membranes controls Hedgehog signaling	88
Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming	87
Bifunctional small molecules that mediate the degradation of extracellular proteins	87
Acoustic biosensors for ultrasound imaging of enzyme activity	87
ROS regulated reversible protein phase separation synchronizes plant flowering	86
Living materials fabricated via gradient mineralization of light-inducible biofilms	85
Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors	85
The HaloTag as a general scaffold for far-red tunable chemigenetic indicators	83
A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs	81
Discovery of a selective inhibitor of doublecortin like kinase 1	80
Functional characterization of a PROTAC directed against BRAF mutant V600E	80
Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects	78
Manumycin polyketides act as molecular glues between UBR7 and P53	78
A community resource for paired genomic and metabolomic data mining	78
Rerouting plant terpene biosynthesis enables momilactone pathway elucidation	76
Metabolic engineering strategies to enable microbial utilization of C1 feedstocks	75
The developing toolkit of continuous directed evolution	75
Optogenetic control of the lac operon for bacterial chemical and protein production	75
A compendium of kinetic modulatory profiles identifies ferroptosis regulators	75
Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation	73
Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy	73
Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2	73
PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase	73
Structural basis for diamide modulation of ryanodine receptor	72
Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals	72
NADP modulates RNA m6A methylation and adipogenesis via enhancing FTO activity	70
Peroxisome compartmentalization of a toxic enzyme improves alkaloid production	70
Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo	70
Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance	69
Chemically informed analyses of metabolomics mass spectrometry data with Qemistree	69
Designer protein assemblies with tunable phase diagrams in living cells	67
Cell type-selective secretome profiling in vivo	67
The origin of genomic N6-methyl-deoxyadenosine in mammalian cells	66
Discovery and resistance mechanism of a selective CDK12 degrader	66
Defining new chemical space for drug penetration into Gram-negative bacteria	65
Deep mutational scanning reveals the structural basis for α-synuclein activity	65
YY1 interacts with guanine quadruplexes to regulate DNA looping and gene expression	64
New codons for efficient production of unnatural proteins in a semisynthetic organism	63
Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease	63
Plant terpenoid metabolism co-opts a component of the cell wall biosynthesis machinery	63
Bottom-up de novo design of functional proteins with complex structural features	62
Target protein deglycosylation in living cells by a nanobody-fused split O-GlcNAcase	62
Water-processable, biodegradable and coatable aquaplastic from engineered biofilms	61
Isoform-selective regulation of mammalian cryptochromes	61
Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast	61
Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants	61

Strategies for monitoring cell–cell interactions	59
Structural insights into probe-dependent positive allosterism of the GLP-1 receptor	58
Organelle membrane-specific chemical labeling and dynamic imaging in living cells	58
NMR and EPR reveal a compaction of the RNA-binding protein FUS upon droplet formation	57
Designer membraneless organelles sequester native factors for control of cell behavior	57
Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes	57
Increasing the efficiency and precision of prime editing with guide RNA pairs	56
VCP/p97 regulates Beclin-1-dependent autophagy initiation	56
Dissecting the Pol II transcription cycle and derailing cancer with CDK inhibitors	55
Programming cell-free biosensors with DNA strand displacement circuits	55
Identification of essential sites of lipid peroxidation in ferroptosis	55
Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling	55
Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor	54
RNA structure probing uncovers RNA structure-dependent biological functions	54
A DNA-based fluorescent probe maps NOS3 activity with subcellular spatial resolution	54
Phase separation of RNA-binding protein promotes polymerase binding and transcription	54
Genetically encoded protein sulfation in mammalian cells	53
An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice	53
PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function	52
Comparative tRNA sequencing and RNA mass spectrometry for surveying tRNA modifications	52
Structural dissimilarity from self drives neoepitope escape from immune tolerance	52
Engineering a precise adenine base editor with minimal bystander editing	52
Learning the chemical grammar of biomolecular condensates	52
Design of orthogonal regulatory systems for modulating gene expression in plants	52
Small molecule probes for targeting autophagy	52
Rapid generation of potent antibodies by autonomous hypermutation in yeast	51
Covalent inhibition of NSD1 histone methyltransferase	51
Adaptive mechanisms of plant specialized metabolism connecting chemistry to function	51
Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice	51
Chromatin as a key consumer in the metabolite economy	50
An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor	50
Acute pharmacological degradation of Helios destabilizes regulatory T cells	50
Bridge helix arginines play a critical role in Cas9 sensitivity to mismatches	50
Cuticle thickness affects dynamics of volatile emission from petunia flowers	49
Activation of the α2B adrenoceptor by the sedative sympatholytic dexmedetomidine	49
KRAS is vulnerable to reversible switch-II pocket engagement in cells	49
Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation	49
Oncohistone mutations enhance chromatin remodeling and alter cell fates	48
Robust direct digital-to-biological data storage in living cells	48
ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells	48
ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth	48
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability	47
Targeting androgen receptor phase separation to overcome antiandrogen resistance	47
Lipid metabolism in T cell signaling and function	45
Computation-guided optimization of split protein systems	45
Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering	44
Structural basis for RING-Cys-Relay E3 ligase activity and its role in axon integrity	44
Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S)	44
Orthogonal fluorescent chemogenetic reporters for multicolor imaging	43
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer	42
Structural basis for non-radical catalysis by TsrM, a radical SAM methylase	41
Chemical strategies to overcome resistance against targeted anticancer therapeutics	41
Structural basis for selectivity in a highly reducing type II polyketide synthase	41
Chains of evidence from correlations to causal molecules in microbiome-linked diseases	41
Lineage tracing and analog recording in mammalian cells by single-site DNA writing	41
Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism	41
Repurposing an adenine riboswitch into a fluorogenic imaging and sensing tag	41
Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel	41
K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle	40
The evolution of synthetic receptor systems	40
G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3	40
Engineering AraC to make it responsive to light instead of arabinose	40
Characterization of a patient-derived variant of GPX4 for precision therapy	40
Conformational rearrangement during activation of a metabotropic glutamate receptor	40
Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii	40
A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization	40
Selective G protein signaling driven by substance P–neurokinin receptor dynamics	39
Ancient plant-like terpene biosynthesis in corals	39
Prospecting for molecular glues	39
Dynamics of an LPS translocon induced by substrate and an antimicrobial peptide	38
Engineering CAR-T cells to activate small-molecule drugs in situ	38
Visualizing a protonated RNA state that modulates microRNA-21 maturation	38
Ion channels as lipid sensors: from structures to mechanisms	38
Reversible lysine-targeted probes reveal residence time-based kinase selectivity	38
Detection of cell–cell interactions via photocatalytic cell tagging	38
H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity	38
Systematic discovery of biomolecular condensate-specific protein phosphorylation	37
Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1	37
CueR activates transcription through a DNA distortion mechanism	37
Selective N-glycan editing on living cell surfaces to probe glycoconjugate function	37

Identification of a potent and selective covalent Pin1 inhibitor	36
A brief guideline for studies of phase-separated biomolecular condensates	36
Spectroscopic coherent Raman imaging of Caenorhabditis elegans reveals lipid particle diversity	35
Characterizing the portability of phage-encoded homologous recombination proteins	35
Allosteric interactions in the parathyroid hormone GPCR–arrestin complex formation	35
Why succinate? Physiological regulation by a mitochondrial coenzyme Q sentinel	35
Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders	35
Discovery and biosynthesis of cyclic plant peptides via autocatalytic cyclases	35
Insights into distinct signaling profiles of the µOR activated by diverse agonists	35
A nucleotide-switch mechanism mediates opposing catalytic activities of Rel enzymes	35
Programmable living assembly of materials by bacterial adhesion	35
Convergent evolution of bacterial ceramide synthesis	34
Reversal of nucleobase methylation by dioxygenases	34
Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine	34
Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target	34
Laboratory evolution of a sortase enzyme that modifies amyloid-β protein	34
Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1	34
Widespread occurrence of covalent lysine–cysteine redox switches in proteins	33
A bioluminescent probe for longitudinal monitoring of mitochondrial membrane potential	33
Using fungible biosensors to evolve improved alkaloid biosyntheses	33
Structural insight into the formation of lipoprotein-β-barrel complexes	33
Topology-dependent interference of synthetic gene circuit function by growth feedback	33
Artificial intelligence foundation for therapeutic science	33
Activity-based RNA-modifying enzyme probing reveals DUS3L-mediated dihydrouridylation	32
A bio-inspired cell-free system for cannabinoid production from inexpensive inputs	32
Crystal structure of human PLD1 provides insight into activation by PI(4,5)P2 and RhoA	32
Permissive epigenomes endow reprogramming competence to transcriptional regulators	32
Molecular basis for arginine C-terminal degron recognition by Cul2FEM1 E3 ligase	32
The conformational cycle of a prototypical voltage-gated sodium channel	32
Production of Tyrian purple indigoid dye from tryptophan in Escherichia coli	32
Ancient defensive terpene biosynthetic gene clusters in the soft corals	32
Combining CRISPRi and metabolomics for functional annotation of compound libraries	31
Use of paramagnetic 19F NMR to monitor domain movement in a glutamate transporter homolog	31
Cryo-EM structure of the RNA-guided ribonuclease Cas12g	31
A proteome-wide map of 20(S)-hydroxycholesterol interactors in cell membranes	31
Functional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2	31
Controllable genome editing with split-engineered base editors	31
Discovery of small-molecule enzyme activators by activity-based protein profiling	31
Genetically encoded multivalent liquid glycan array displayed on M13 bacteriophage	31
Glucosylation prevents plant defense activation in phloem-feeding insects	30
Prospecting for natural products by genome mining and microcrystal electron diffraction	30
A mass spectrometry-based proteome map of drug action in lung cancer cell lines	30
Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth	30
Modeling the expansion of virtual screening libraries	30
Biosynthesis of triacsin featuring an N-hydroxytriazene pharmacophore	30
CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation	30
Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain	30
YAP-dependent proliferation by a small molecule targeting annexin A2	29
Targeted degradation via direct 26S proteasome recruitment	29
Structure-based investigation of fluorogenic Pepper aptamer	29
Precise genome editing across kingdoms of life using retron-derived DNA	29
Imaging and targeting LOX-mediated tissue remodeling with a reactive collagen peptide	29
Bright and stable luminescent probes for target engagement profiling in live cells	29
Engineered LwaCas13a with enhanced collateral activity for nucleic acid detection	29
Engineering orthogonal human O-linked glycoprotein biosynthesis in bacteria	29
Dynamic crotonylation of EB1 by TIP60 ensures accurate spindle positioning in mitosis	29
Enzymatic C–H activation of aromatic compounds through CO2 fixation	29
Molecular and environmental determinants of biomolecular condensate formation	28
Tools, tactics and objectives to interrogate cellular roles of O-GlcNAc in disease	28
p63 uses a switch-like mechanism to set the threshold for induction of apoptosis	28
O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1	28
Active turnover of genomic methylcytosine in pluripotent cells	28
Spatial decoding of endosomal cAMP signals by a metastable cytoplasmic PKA network	28
HIV-1 fusion inhibitors targeting the membrane-proximal external region of Env spikes	28
A new dawn beyond lysine ubiquitination	28
Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains	28
Microtubule lattice spacing governs cohesive envelope formation of tau family proteins	28
Programmable synthetic biomolecular condensates for cellular control	27
Site-specific ubiquitination affects protein energetics and proteasomal degradation	27
Mechanical strength of RNA knot in Zika virus protects against cellular defenses	27
Membrane phase separation drives responsive assembly of receptor signaling domains	27
Drug antagonism and single-agent dominance result from differences in death kinetics	27
Atomic structure of potato virus X, the prototype of the Alphaflexiviridae family	26
A quantitative method for proteome reallocation using minimal regulatory interventions	26
A bifunctional O-antigen polymerase structure reveals a new glycosyltransferase family	26
Synthetic protein condensates for cellular and metabolic engineering	26
Structures of the human cholecystokinin receptors bound to agonists and antagonists	26
Peroxisomal-derived ether phospholipids link nucleotides to respirasome assembly	26
Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler	25
Modulation of auxin formation by the cytosolic phenylalanine biosynthetic pathway	25
Molecular basis for ubiquitin ligase CRL2FEM1C-mediated recognition of C-degron	25
Identifying cell receptors for the nanoparticle protein corona using genome screens	25
Reaction pathway engineering converts a radical hydroxylase into a halogenase	25
A roadmap to creating ferroptosis-based medicines	25
Structural basis for persulfide-sensing specificity in a transcriptional regulator	24
Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis	24
Harnessing nanotechnology to expand the toolbox of chemical biology	24
HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain	24
Peroxiredoxins couple metabolism and cell division in an ultradian cycle	24
Mutanofactin promotes adhesion and biofilm formation of cariogenic Streptococcus mutans	24
Structural and functional diversity among agonist-bound states of the GLP-1 receptor	24
Hovlinc is a recently evolved class of ribozyme found in human lncRNA	24
Pyridoxal-5′-phosphate-dependent alkyl transfer in nucleoside antibiotic biosynthesis	24
Quantitative profiling of pseudouridylation landscape in the human transcriptome	24
Engineering site-selective incorporation of fluorine into polyketides	23