Nature Chemical Biology

Article	Citations
Flipping the polarity switch	307
Altering the cap	262
Sensing the air	238
Cyclic signature	207
Making a 6mA demethylase	184
Development of cyclic peptides that can be administered orally to inhibit disease targets	182
Chemical targeting of amyloids	173
To TnpB or not TnpB? Cas12 is the answer	152
Channeling kynurenine	151
Bacteria lose a pep in their step	144
A vicious cycle	144
Assembly-activated aggregation	142
Seeing the retention	129
Detecting features of antibody structure through their mediator-accessible redox activities	128
Facile generation of drug-like conformational antibodies specific for amyloid fibrils	126
Inter-kingdom electromechanical communication	125
E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells	124
An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation	123
The landscape of targets and lead molecules for remyelination	122
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	115
Calcium-gated potassium channel blockade via membrane-facing fenestrations	115
Chemigenetic indicators based on synthetic chelators and green fluorescent protein	110
Determining the role of peroxidation of subcellular lipid membranes in ferroptosis	107
Sterol homeostasis in yeast	106
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates	103

Small-molecule dissolution of stress granules by redox modulation benefits ALS models	100
Rationally seeded computational protein design of ɑ-helical barrels	99
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms	95
Surviving salt stress	94
Engineering eukaryotic transposon-encoded Fanzor2 system for genome editing in mammals	93
A pseudoenzyme enables indole biosynthesis in eudicot plants	91
Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis	90
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability	90
A class of anti-inflammatory lipids decrease with aging in the central nervous system	88
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux	88
Artificial intelligence foundation for therapeutic science	87
Small-molecule trapping of an RNA-binding protein blocks cancer cell growth	87
ALFA nanobody-guided endogenous labeling	87
Controlling sulfation	86
Seismic shift	86
Making transient complexes stick	85
Peptides hit the catalysis walk	84
Visualizing drug effects over time in live animals using optical pharmacodynamics	84
Tuned out	84
Brake disposal	82
Badminton at nanoscale	82
Running through the blocks	81
Endogenous currents in HEK 293 cells are inhibited by memantine	79
Site-specific encoding of photoactivity and photoreactivity into antibody fragments	78
Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells	78
Open-ended molecular recording of sequential cellular events into DNA	78
A super protein evolution engine	78
Discovery and molecular basis of subtype-selective cyclophilin inhibitors	77
Functional profiling of serine, threonine and tyrosine sites	76
Programmed RNA editing with an evolved bacterial adenosine deaminase	75
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins	74
Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II	72
Development of an allosteric adhesion GPCR nanobody with therapeutic potential	71
Small molecule inhibits KCNQ channels with a non-blocking mechanism	71
An optimized bioluminescent substrate for non-invasive imaging in the brain	71
M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome	70
Oncometabolite 5-IP7 inhibits inositol 5-phosphatase to license E-cadherin endocytosis	70
SNAP-tag2 for faster and brighter protein labeling	70
Degrade the RNA	67
Survival of the sweetest tooth	67
Medicine from modified mRNA	66
Protein evolution as a complex system	65
Lighting up kinase contacts in situ	65
Waking sleeping viruses	65
The right angle	64
RNA-based programmable DNA cleavage	62
Synthesizing cellular LOGIC	62
NO signal	60
A home for orphans	59
Superbugs leave fingerprints	58

Affinity for both sides	58
Structural basis of efficacy-driven ligand selectivity at GPCRs	57
Hydroxytryptophan biosynthesis by a family of heme-dependent enzymes in bacteria	56
All that glows is gold	56
Molecular basis of β-arrestin coupling to the metabotropic glutamate receptor mGlu3	56
Lighting up hydrogen peroxide	56
Selective bioorthogonal probe for N-glycan hybrid structures	55
Engineering a xylose fermenting yeast for lignocellulosic ethanol production	55
Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection	55
ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	54
Functional targeting of membrane transporters and enzymes to peroxisomes	54
Programmable RNA base editing via targeted modifications	53
Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis	53
Engineering APOBEC3A deaminase for highly accurate and efficient base editing	53
Improving phenotypic screening	52
Single-cell sensor analyses reveal signaling programs enabling Ras-G12C drug resistance	52
Direct methylation sequencing	52
An unbiased proteomic platform for ATE1-based arginylation profiling	51
Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily	51
Pharmacological targeting of BMAL1 modulates circadian and immune pathways	51
Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity	51
Catch in nucleus	50
Direct mapping of tyrosine sulfation states in native peptides by nanopore	50
Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii	50
Switching off the stress response	49
Sweet synthetic chaperones	49
Providing inclusivity	49
Prospering phase separation	48
Dissociation for living	48
Illuminating GPCR trafficking	48
Author Correction: Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM	47
A peptide dehydratase with core strength	47
A fat-fueled fatality	46
A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein	46
Unfreezing structural biology for drug discovery	46
Phase in phase	45
A single-component, light-assisted uncaging switch for endoproteolytic release	45
Signal peptide mimicry primes Sec61 for client-selective inhibition	44
Chemical-based epigenetic reprogramming to advance pluripotency and totipotency	44
Site-selective protein editing by backbone extension acyl rearrangements	44
Dynamic basis for dA•dGTP and dA•d8OGTP misincorporation via Hoogsteen base pairs	44
ALDH2-mediated GABA biosynthesis regulates hippocampal LTP and learning adaptability	44
Publisher Correction: Mutant p53 protein accumulation is selectively targetable by proximity-inducing drugs	44
Inhibition of translation termination by the antimicrobial peptide Drosocin	44
Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1	43
Anti-infective bile acids bind and inactivate a Salmonella virulence regulator	43
Chemically engineered antibodies for autophagy-based receptor degradation	43
In-cell kinetic stability is an essential trait in metallo-β-lactamase evolution	43
Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5	42
Helping sperm keep the beat	41
Chemically inducible split protein regulators for mammalian cells	41
Interactions with tau’s microtubule-binding repeats modulate amyloid-β aggregation and toxicity	41
The β-subunit of tryptophan synthase is a latent tyrosine synthase	41
Writing the CRBN degron	41
A CRISPR activation screen identifies FBXO22 supporting targeted protein degradation	40
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism	40
Modulation of microbial community dynamics by spatial partitioning	39
Nanopore glycan profiling	39
Genome mining for unknown–unknown natural products	39
A rapid chemical reprogramming system to generate human pluripotent stem cells	39
Alzheimer’s disease–implicated protein tau puts the squeeze on microtubules	39
Enzyme assemblies on demand	38
Capturing receptor states with glue	38
Author Correction: An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity	38
Deep dive into a drug pump	37
Under pressure	37
Lighting up DNA	37
Size matters	37
Expanding beyond the capability of nature	37
Chemical Decoding of Spatial Biology	36
Forced rewiring of RTK signaling	36
When membrane proteins prefer lipids	36
Publisher Correction: Polyvalent folate receptor-targeting chimeras for degradation of membrane proteins	36
Rapid discovery of cyclic peptide protein aggregation inhibitors by continuous selection	36
Melting KRAS resistance	36
Imbuing peptide libraries with drug-likeness	36
Lipoyl deglutarylation by ABHD11 regulates mitochondrial and T cell metabolism	36
Disarming the pathogen	36
Thoughts for the future	36
Bending insulin signals	36

A PASS for protein secretion	36
Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36	35
Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168	35
The realization of CRISPR gene therapy	34
Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands	34
A modification-centric assessment tool for the performance of chemoproteomic probes	34
Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus	34
Structural basis of AcrIF24 as an anti-CRISPR protein and transcriptional suppressor	34
Structural basis of TRPV3 inhibition by an antagonist	34
A tungstopterin-containing enzyme has a key role in microbial ethanol biosynthesis	34
CRISPR–Cas12a-mediated DNA clamping triggers target-strand cleavage	33
Hippo pathway regulation by phosphatidylinositol transfer protein and phosphoinositides	33
Dissolution of oncofusion transcription factor condensates for cancer therapy	33
An allosteric redox switch involved in oxygen protection in a CO2 reductase	33
Engineering from evolution	32
Click, release, destroy	32
Genetically engineered synthetic cells activate cargo release upon temperature shift	32
Shackled ribosomes unleashed	32
Author Correction: Combining CRISPRi and metabolomics for functional annotation of compound libraries	32
Redefining the off switch	32
Spontaneously established syntrophic yeast communities improve bioproduction	32
Evading resistance at the double	31
Basket of sweets	31
Studying ATP synthesis in situ	31
Moonlighting in the membrane	31
An alternative mechanism for recruiting Cas2/3 in a phage-encoded CRISPR–Cas system	31
Auxin branches out	30
A Ψ–Ψ codon–anticodon pairing in nonsense suppression and translational recoding	30
Exchange coupling	30
Author Correction: A cell-free biosensor signal amplification circuit with polymerase strand recycling	30
Click biology highlights the opportunities from reliable biological reactions	30
A single sensor controls large variations in zinc quotas in a marine cyanobacterium	30
A new class of macrocyclic peptides	29
Enhancing RNA base editing on mammalian transcripts with small nuclear RNAs	29
Shifting redox reaction equilibria on demand using an orthogonal redox cofactor	29
Bringing chemistry to medicine to redefine the undruggable	29
Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma	29
Selective targeting of oncogenic hotspot mutations of the HER2 extracellular domain	29
TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids	29
Receptors from an ADAR trick	29
Small-molecule inhibition of the archetypal UbiB protein COQ8	29
Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift	29
Unbalanced response to growth variations reshapes the cell fate decision landscape	29
Enzymatic synthesis of peptide therapeutics	28
Programming biological communication between distinct membraneless compartments	28
State of play	28
Programmable translation	28
Chemical editing of proteoglycan architecture	28
Engineered bacterial swarm patterns as spatial records of environmental inputs	28
De novo development of small cyclic peptides that are orally bioavailable	28
In search of chemical rationales	28
Building light-activated synthetic cells that induce gene expression in bacteria via quorum sensing	27
Learning from CoQ10 history	27
Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R	27
Design principles imprinted by evolution	27
Traffic control	27
Recording calcium concentrations	27
Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death	27
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer	27
Long-term super-resolution inner mitochondrial membrane imaging with a lipid probe	27
Antibodies expand the scope of angiotensin receptor pharmacology	27
Identifying p53-independent apoptosis	27
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor	27
Partitioning of a 2-bit hash function across 66 communicating cells	27
Aiming for the pocket	27
In silico prohormone processing	26
Context-based sensing of orthosomycin antibiotics by the translating ribosome	26
Mechanism of capsaicin entry into buried vanilloid sites in TRPV1	26
Programmable solid-state condensates for spatiotemporal control of mammalian gene expression	26
Non-heme iron enzymes step into the spotlight	26
Proximity-inducing pharmacology	26
Cryptic enzymatic assembly of peptides armed with β-lactone warheads	26
GA-independent DELLA regulation by inositol pyrophosphate in a nonvascular land plant	26
Cutting the tail	25
Artificial intelligence uncovers carcinogenic human metabolites	25
Site-resolved energetic information from HX–MS experiments	25
Capturing copper to inhibit inflammation	25
The protein universe in 3D	25
A new RNA performs old chemistry	24
A gut feeling	24
Molecular glue modulates mitochondria	24
Expanding the molecular grammar of polar residues and arginine in FUS phase separation	24
Drivers of intrinsic resistance	24
Stress it up	24
Combining CRISPRi and metabolomics for functional annotation of compound libraries	24
A new twist to increase ion flow	24
One-carbon footprint in B cells	24
Protein-based bandpass filters for controlling cellular signaling with chemical inputs	23
Pseudouridines in translation	23
Pharmacological inhibition of PSPH reduces serine levels and epileptic seizures	23
Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system	23
Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation	23
Old path, new frontier	23
Galectin-13 reduces membrane localization of SLC7A11 for ferroptosis propagation	23
Brassinosteroids en route	23