OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Chemical Biology is 67. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Flipping the polarity switch	290
Altering the cap	245
Sensing the air	219
A sulfate amuse-bouche	204
Cyclic signature	189
Surviving salt stress	174
Making a 6mA demethylase	173
Development of cyclic peptides that can be administered orally to inhibit disease targets	167
Chemical targeting of amyloids	141
To TnpB or not TnpB? Cas12 is the answer	140
Channeling kynurenine	140
A vicious cycle	134
Bacteria lose a pep in their step	129
Assembly-activated aggregation	120
Seeing the retention	118
Small-molecule dissolution of stress granules by redox modulation benefits ALS models	116
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms	116
The landscape of targets and lead molecules for remyelination	115
Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis	114
Artificial intelligence foundation for therapeutic science	112
A pseudoenzyme enables indole biosynthesis in eudicot plants	107
ALFA nanobody-guided endogenous labeling	107
Inter-kingdom electromechanical communication	101
E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells	100
An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation	99

Calcium-gated potassium channel blockade via membrane-facing fenestrations	95
Determining the role of peroxidation of subcellular lipid membranes in ferroptosis	95
Engineering eukaryotic transposon-encoded Fanzor2 system for genome editing in mammals	94
Detecting features of antibody structure through their mediator-accessible redox activities	92
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux	91
Chemigenetic indicators based on synthetic chelators and green fluorescent protein	90
Facile generation of drug-like conformational antibodies specific for amyloid fibrils	88
Sterol homeostasis in yeast	87
Rationally seeded computational protein design of ɑ-helical barrels	86
Characterization of a patient-derived variant of GPX4 for precision therapy	84
Programmable living assembly of materials by bacterial adhesion	84
A class of anti-inflammatory lipids decrease with aging in the central nervous system	84
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates	84
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability	84
Small-molecule trapping of an RNA-binding protein blocks cancer cell growth	82
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	82
Seismic shift	81
Controlling sulfation	80
Visualizing drug effects over time in live animals using optical pharmacodynamics	79
Making transient complexes stick	79
Oncometabolite 5-IP7 inhibits inositol 5-phosphatase to license E-cadherin endocytosis	78
Tuned out	77
Peptides hit the catalysis walk	77
Running through the blocks	76
Brake disposal	76
Badminton at nanoscale	76
Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells	75
Structure-based investigation of fluorogenic Pepper aptamer	74
Development of an allosteric adhesion GPCR nanobody with therapeutic potential	73
An optimized bioluminescent substrate for non-invasive imaging in the brain	73
Endogenous currents in HEK 293 cells are inhibited by memantine	73
Programmed RNA editing with an evolved bacterial adenosine deaminase	72
Site-specific encoding of photoactivity and photoreactivity into antibody fragments	72
A wrench in the motor	71
Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II	71
Small molecule targeting of chromatin writers in cancer	70
Small molecule inhibits KCNQ channels with a non-blocking mechanism	70
Functional profiling of serine, threonine and tyrosine sites	70
Open-ended molecular recording of sequential cellular events into DNA	68
SNAP-tag2 for faster and brighter protein labeling	68
Discovery and molecular basis of subtype-selective cyclophilin inhibitors	68
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins	68
M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome	67