OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Chemical Biology is 68. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Flipping the polarity switch	352
Altering the cap	273
Sensing the air	211
Cyclic signature	187
Development of cyclic peptides that can be administered orally to inhibit disease targets	175
To TnpB or not TnpB? Cas12 is the answer	175
Channeling kynurenine	171
Bacteria lose a pep in their step	159
Seeing the retention	152
Facile generation of drug-like conformational antibodies specific for amyloid fibrils	147
Inter-kingdom electromechanical communication	146
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability	144
Calcium-gated potassium channel blockade via membrane-facing fenestrations	143
Rapid evolution of a highly efficient RNA polymerase by homologous recombination	142
Chemical targeting of amyloids	141
Development of the fluorescent probe CenSpark for labeling centrioles and cilia	137
Making a 6mA demethylase	126
Complexoform-specific ligands that modulate the pleiotropic methyltransferase adaptor TRMT112	126
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	119
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates	118
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux	117
A pseudoenzyme enables indole biosynthesis in eudicot plants	117
Rationally seeded computational protein design of ɑ-helical barrels	116
Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis	114
E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells	111

Small-molecule dissolution of stress granules by redox modulation benefits ALS models	107
Determining the role of peroxidation of subcellular lipid membranes in ferroptosis	106
Detecting features of antibody structure through their mediator-accessible redox activities	106
Artificial intelligence foundation for therapeutic science	106
The landscape of targets and lead molecules for remyelination	105
Sterol homeostasis in yeast	105
An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation	102
Engineering eukaryotic transposon-encoded Fanzor2 system for genome editing in mammals	99
ALFA nanobody-guided endogenous labeling	99
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms	98
A class of anti-inflammatory lipids decrease with aging in the central nervous system	98
Surviving salt stress	97
Chemigenetic indicators based on synthetic chelators and green fluorescent protein	96
Small-molecule trapping of an RNA-binding protein blocks cancer cell growth	93
Assembly-activated aggregation	93
Seismic shift	93
Controlling sulfation	92
Making transient complexes stick	91
Small molecule inhibits KCNQ channels with a non-blocking mechanism	91
Peptides hit the catalysis walk	90
Tuned out	86
Brake disposal	85
Badminton at nanoscale	85
Running through the blocks	84
Open-ended molecular recording of sequential cellular events into DNA	83
Advances in BRET probes for intracellular target engagement studies	82
Endogenous currents in HEK 293 cells are inhibited by memantine	81
A super protein evolution engine	80
Visualizing drug effects over time in live animals using optical pharmacodynamics	79
Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells	78
Development of an allosteric adhesion GPCR nanobody with therapeutic potential	78
Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II	77
Discovery and molecular basis of subtype-selective cyclophilin inhibitors	75
Functional profiling of serine, threonine and tyrosine sites	75
An evolution-conserved allosteric network in human tubulin governs paclitaxel efficacy	74
Programmed RNA editing with an evolved bacterial adenosine deaminase	74
Condensation-independent intramodular translocation mechanism of the trans-AT polyketide synthase assembly line	74
Oncometabolite 5-IP7 inhibits inositol 5-phosphatase to license E-cadherin endocytosis	73
An optimized bioluminescent substrate for non-invasive imaging in the brain	73
Site-specific encoding of photoactivity and photoreactivity into antibody fragments	72
SNAP-tag2 for faster and brighter protein labeling	71
Survival of the sweetest tooth	69
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins	69
Lighting up kinase contacts in situ	68