OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Chemical Biology is 62. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation	265
Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal	199
Mechanistic dissection of increased enzymatic rate in a phase-separated compartment	182
Structure- and mechanism-guided design of single fluorescent protein-based biosensors	154
Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2	152
Programmed genome editing by a miniature CRISPR-Cas12f nuclease	151
Deubiquitinase-targeting chimeras for targeted protein stabilization	149
Accelerated RNA detection using tandem CRISPR nucleases	147
Structural and functional consequences of reversible lipid asymmetry in living membranes	143
Hydrogel-based biocontainment of bacteria for continuous sensing and computation	139
Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity	134
Controlling and enhancing CRISPR systems	123
Identification of essential sites of lipid peroxidation in ferroptosis	116
ROS regulated reversible protein phase separation synchronizes plant flowering	113
Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation	113
Bifunctional small molecules that mediate the degradation of extracellular proteins	106
Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii	104
The HaloTag as a general scaffold for far-red tunable chemigenetic indicators	104
Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals	100
Living materials fabricated via gradient mineralization of light-inducible biofilms	99
Cholesterol access in cellular membranes controls Hedgehog signaling	98
Metabolic engineering strategies to enable microbial utilization of C1 feedstocks	98
Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast	95
Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo	91
Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy	89

A compendium of kinetic modulatory profiles identifies ferroptosis regulators	86
A community resource for paired genomic and metabolomic data mining	86
Lipid metabolism in T cell signaling and function	85
Engineering a precise adenine base editor with minimal bystander editing	84
YY1 interacts with guanine quadruplexes to regulate DNA looping and gene expression	83
Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance	83
Cell type-selective secretome profiling in vivo	81
Learning the chemical grammar of biomolecular condensates	81
Defining new chemical space for drug penetration into Gram-negative bacteria	79
Strategies for monitoring cell–cell interactions	78
Discovery and resistance mechanism of a selective CDK12 degrader	78
Designer membraneless organelles sequester native factors for control of cell behavior	77
Water-processable, biodegradable and coatable aquaplastic from engineered biofilms	76
VCP/p97 regulates Beclin-1-dependent autophagy initiation	76
Chemically informed analyses of metabolomics mass spectrometry data with Qemistree	76
Programming cell-free biosensors with DNA strand displacement circuits	76
Adaptive mechanisms of plant specialized metabolism connecting chemistry to function	75
Bottom-up de novo design of functional proteins with complex structural features	73
Target protein deglycosylation in living cells by a nanobody-fused split O-GlcNAcase	72
Phase separation of RNA-binding protein promotes polymerase binding and transcription	72
Increasing the efficiency and precision of prime editing with guide RNA pairs	70
Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S)	70
Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes	69
RNA structure probing uncovers RNA structure-dependent biological functions	68
NMR and EPR reveal a compaction of the RNA-binding protein FUS upon droplet formation	68
Acute pharmacological degradation of Helios destabilizes regulatory T cells	67
ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth	67
Small molecule probes for targeting autophagy	67
Rapid generation of potent antibodies by autonomous hypermutation in yeast	66
Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease	66
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer	66
Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor	65
Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants	65
Membrane phase separation drives responsive assembly of receptor signaling domains	64
Oncohistone mutations enhance chromatin remodeling and alter cell fates	62
Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation	62
Targeting androgen receptor phase separation to overcome antiandrogen resistance	62