OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Chemical Biology is 65. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Flipping the polarity switch	389
Cyclic signature	313
Development of cyclic peptides that can be administered orally to inhibit disease targets	219
To TnpB or not TnpB? Cas12 is the answer	192
Channeling kynurenine	192
Bacteria lose a pep in their step	189
Seeing the retention	178
Chemical targeting of amyloids	162
Sterol homeostasis in yeast	159
Surviving salt stress	158
Assembly-activated aggregation	154
Detecting features of antibody structure through their mediator-accessible redox activities	153
Complexoform-specific ligands that modulate the pleiotropic methyltransferase adaptor TRMT112	153
E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells	153
ALFA nanobody-guided endogenous labeling	143
Development of the fluorescent probe CenSpark for labeling centrioles and cilia	142
Rapid evolution of a highly efficient RNA polymerase by homologous recombination	135
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	127
Inter-kingdom electromechanical communication	127
A pseudoenzyme enables indole biosynthesis in eudicot plants	124
Chemigenetic indicators based on synthetic chelators and green fluorescent protein	123
Engineering eukaryotic transposon-encoded Fanzor2 system for genome editing in mammals	120
The landscape of targets and lead molecules for remyelination	119
Determining the role of peroxidation of subcellular lipid membranes in ferroptosis	119
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms	119

Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux	116
Facile generation of drug-like conformational antibodies specific for amyloid fibrils	112
Rationally seeded computational protein design of ɑ-helical barrels	112
Calcium-gated potassium channel blockade via membrane-facing fenestrations	110
A class of anti-inflammatory lipids decrease with aging in the central nervous system	108
Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis	103
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates	100
Small-molecule dissolution of stress granules by redox modulation benefits ALS models	98
Artificial intelligence foundation for therapeutic science	96
Designing fiber–gut microbiome interactions with active learning	94
An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation	94
Seismic shift	93
Small-molecule trapping of an RNA-binding protein blocks cancer cell growth	93
Peptides hit the catalysis walk	92
Controlling sulfation	92
Badminton at nanoscale	91
Brake disposal	88
Running through the blocks	84
Discovery and molecular basis of subtype-selective cyclophilin inhibitors	81
A super protein evolution engine	80
Condensation-independent intramodular translocation mechanism of the trans-AT polyketide synthase assembly line	80
An evolution-conserved allosteric network in human tubulin governs paclitaxel efficacy	80
Endogenous currents in HEK 293 cells are inhibited by memantine	80
Oncometabolite 5-IP7 inhibits inositol 5-phosphatase to license E-cadherin endocytosis	80
Visualizing drug effects over time in live animals using optical pharmacodynamics	79
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins	76
Functional profiling of serine, threonine and tyrosine sites	76
Making transient complexes stick	75
Small molecule inhibits KCNQ channels with a non-blocking mechanism	74
Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II	74
Site-specific encoding of photoactivity and photoreactivity into antibody fragments	72
SNAP-tag2 for faster and brighter protein labeling	70
Programmed RNA editing with an evolved bacterial adenosine deaminase	69
Development of an allosteric adhesion GPCR nanobody with therapeutic potential	69
Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells	68
Open-ended molecular recording of sequential cellular events into DNA	66
Advances in BRET probes for intracellular target engagement studies	66
Survival of the sweetest tooth	65
The right angle	65
An optimized bioluminescent substrate for non-invasive imaging in the brain	65
Lighting up kinase contacts in situ	65