OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Chemical Biology is 66. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Flipping the polarity switch	367
Altering the cap	287
Sensing the air	213
Cyclic signature	193
Development of cyclic peptides that can be administered orally to inhibit disease targets	180
To TnpB or not TnpB? Cas12 is the answer	177
Channeling kynurenine	176
Bacteria lose a pep in their step	161
Seeing the retention	160
Chemical targeting of amyloids	148
Facile generation of drug-like conformational antibodies specific for amyloid fibrils	148
Making a 6mA demethylase	147
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms	147
Sterol homeostasis in yeast	146
Surviving salt stress	143
Assembly-activated aggregation	139
A pseudoenzyme enables indole biosynthesis in eudicot plants	127
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux	126
Chemigenetic indicators based on synthetic chelators and green fluorescent protein	121
E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells	121
Complexoform-specific ligands that modulate the pleiotropic methyltransferase adaptor TRMT112	121
Detecting features of antibody structure through their mediator-accessible redox activities	120
Determining the role of peroxidation of subcellular lipid membranes in ferroptosis	119
ALFA nanobody-guided endogenous labeling	118
The landscape of targets and lead molecules for remyelination	113

Development of the fluorescent probe CenSpark for labeling centrioles and cilia	111
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	109
Calcium-gated potassium channel blockade via membrane-facing fenestrations	109
Engineering eukaryotic transposon-encoded Fanzor2 system for genome editing in mammals	108
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates	107
Small-molecule dissolution of stress granules by redox modulation benefits ALS models	106
A class of anti-inflammatory lipids decrease with aging in the central nervous system	103
Rationally seeded computational protein design of ɑ-helical barrels	102
An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation	99
Inter-kingdom electromechanical communication	98
Artificial intelligence foundation for therapeutic science	94
Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis	93
Rapid evolution of a highly efficient RNA polymerase by homologous recombination	93
Small-molecule trapping of an RNA-binding protein blocks cancer cell growth	92
Controlling sulfation	89
Seismic shift	89
Making transient complexes stick	88
Development of an allosteric adhesion GPCR nanobody with therapeutic potential	87
Peptides hit the catalysis walk	86
Badminton at nanoscale	85
Running through the blocks	84
Brake disposal	84
Programmed RNA editing with an evolved bacterial adenosine deaminase	83
Discovery and molecular basis of subtype-selective cyclophilin inhibitors	83
An optimized bioluminescent substrate for non-invasive imaging in the brain	82
Condensation-independent intramodular translocation mechanism of the trans-AT polyketide synthase assembly line	81
Endogenous currents in HEK 293 cells are inhibited by memantine	79
A super protein evolution engine	78
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins	76
Open-ended molecular recording of sequential cellular events into DNA	75
Site-specific encoding of photoactivity and photoreactivity into antibody fragments	75
Oncometabolite 5-IP7 inhibits inositol 5-phosphatase to license E-cadherin endocytosis	75
Visualizing drug effects over time in live animals using optical pharmacodynamics	74
An evolution-conserved allosteric network in human tubulin governs paclitaxel efficacy	74
Advances in BRET probes for intracellular target engagement studies	73
SNAP-tag2 for faster and brighter protein labeling	71
Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells	71
Small molecule inhibits KCNQ channels with a non-blocking mechanism	70
Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II	70
Functional profiling of serine, threonine and tyrosine sites	66
Survival of the sweetest tooth	66