OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Chemical Biology is 65. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape	397
Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers	328
TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome	276
Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles	224
LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation	205
SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging	205
Rational discovery of molecular glue degraders via scalable chemical profiling	192
Targeted glycan degradation potentiates the anticancer immune response in vivo	188
m6A-binding YTHDF proteins promote stress granule formation	178
Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal	167
Mechanistic dissection of increased enzymatic rate in a phase-separated compartment	144
In vitro prototyping and rapid optimization of biosynthetic enzymes for cell design	137
Structure- and mechanism-guided design of single fluorescent protein-based biosensors	131
A metabolic labeling method detects m6A transcriptome-wide at single base resolution	130
Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2	127
Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products	125
Accelerated RNA detection using tandem CRISPR nucleases	123
Unifying principles of bifunctional, proximity-inducing small molecules	122
Deubiquitinase-targeting chimeras for targeted protein stabilization	120
Antibody-free enzyme-assisted chemical approach for detection of N6-methyladenosine	119
Structural and functional consequences of reversible lipid asymmetry in living membranes	118
Programmed genome editing by a miniature CRISPR-Cas12f nuclease	116
Electric field stimulates production of highly conductive microbial OmcZ nanowires	111
Hydrogel-based biocontainment of bacteria for continuous sensing and computation	107
Controlling and enhancing CRISPR systems	104

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity	103
A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway	98
Pyruvate-responsive genetic circuits for dynamic control of central metabolism	89
Formation and functionalization of membraneless compartments in Escherichia coli	89
Cholesterol access in cellular membranes controls Hedgehog signaling	88
Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming	87
Bifunctional small molecules that mediate the degradation of extracellular proteins	87
Acoustic biosensors for ultrasound imaging of enzyme activity	87
ROS regulated reversible protein phase separation synchronizes plant flowering	86
Living materials fabricated via gradient mineralization of light-inducible biofilms	85
Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors	85
The HaloTag as a general scaffold for far-red tunable chemigenetic indicators	83
A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs	81
Functional characterization of a PROTAC directed against BRAF mutant V600E	80
Discovery of a selective inhibitor of doublecortin like kinase 1	80
Manumycin polyketides act as molecular glues between UBR7 and P53	78
A community resource for paired genomic and metabolomic data mining	78
Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects	78
Rerouting plant terpene biosynthesis enables momilactone pathway elucidation	76
The developing toolkit of continuous directed evolution	75
Optogenetic control of the lac operon for bacterial chemical and protein production	75
A compendium of kinetic modulatory profiles identifies ferroptosis regulators	75
Metabolic engineering strategies to enable microbial utilization of C1 feedstocks	75
Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2	73
PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase	73
Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation	73
Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy	73
Structural basis for diamide modulation of ryanodine receptor	72
Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals	72
Peroxisome compartmentalization of a toxic enzyme improves alkaloid production	70
Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo	70
NADP modulates RNA m6A methylation and adipogenesis via enhancing FTO activity	70
Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance	69
Chemically informed analyses of metabolomics mass spectrometry data with Qemistree	69
Designer protein assemblies with tunable phase diagrams in living cells	67
Cell type-selective secretome profiling in vivo	67
The origin of genomic N6-methyl-deoxyadenosine in mammalian cells	66
Discovery and resistance mechanism of a selective CDK12 degrader	66
Defining new chemical space for drug penetration into Gram-negative bacteria	65
Deep mutational scanning reveals the structural basis for α-synuclein activity	65