OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Chemical Biology is 64. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Making a 6mA demethylase	244
Chemical targeting of amyloids	223
To TnpB or not TnpB? Cas12 is the answer	197
Channeling kynurenine	197
Detecting features of antibody structure through their mediator-accessible redox activities	194
A sulfate amuse-bouche	188
Cyclic signature	181
Surviving salt stress	167
Development of cyclic peptides that can be administered orally to inhibit disease targets	159
A vicious cycle	158
Flipping the polarity switch	157
Sterol homeostasis in yeast	156
Altering the cap	131
Sensing the air	123
Seeing the retention	122
Publisher Correction: Accelerated RNA detection using tandem CRISPR nucleases	116
Assembly-activated aggregation	116
Bacteria lose a pep in their step	111
An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation	110
Determining the role of peroxidation of subcellular lipid membranes in ferroptosis	108
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	107
Facile generation of drug-like conformational antibodies specific for amyloid fibrils	106
Rationally seeded computational protein design of ɑ-helical barrels	104
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux	102
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability	98

Characterization of a patient-derived variant of GPX4 for precision therapy	97
Engineering eukaryotic transposon-encoded Fanzor2 system for genome editing in mammals	93
Lysosome-targeting chimeras evolve	93
Inter-kingdom electromechanical communication	91
E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells	89
A pseudoenzyme enables indole biosynthesis in eudicot plants	88
Calcium-gated potassium channel blockade via membrane-facing fenestrations	88
Artificial intelligence foundation for therapeutic science	88
Small-molecule dissolution of stress granules by redox modulation benefits ALS models	86
Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis	85
A class of anti-inflammatory lipids decrease with aging in the central nervous system	83
The landscape of targets and lead molecules for remyelination	83
Programmable living assembly of materials by bacterial adhesion	82
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates	81
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms	81
Seismic shift	80
Chemigenetic indicators based on synthetic chelators and green fluorescent protein	80
Small-molecule trapping of an RNA-binding protein blocks cancer cell growth	79
The core of the matter	78
Controlling sulfation	77
Brake disposal	76
M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome	75
Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells	75
Running through the blocks	75
Small molecule targeting of chromatin writers in cancer	74
Escherichia coli small molecule metabolism at the host–microorganism interface	73
Functional profiling of serine, threonine and tyrosine sites	73
Badminton at nanoscale	72
Peptides hit the catalysis walk	72
Tuned out	72
Making transient complexes stick	71
A wrench in the motor	70
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins	69
Small molecule inhibits KCNQ channels with a non-blocking mechanism	67
Endogenous currents in HEK 293 cells are inhibited by memantine	67
Engineering CAR-T cells to activate small-molecule drugs in situ	67
Development of an allosteric adhesion GPCR nanobody with therapeutic potential	67
Discovery and molecular basis of subtype-selective cyclophilin inhibitors	64
Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II	64