OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Chemical Biology is 64. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Making a 6mA demethylase	259
Chemical targeting of amyloids	237
To TnpB or not TnpB? Cas12 is the answer	204
Channeling kynurenine	202
A sulfate amuse-bouche	199
Cyclic signature	187
Surviving salt stress	174
Development of cyclic peptides that can be administered orally to inhibit disease targets	166
A vicious cycle	162
Flipping the polarity switch	160
Sterol homeostasis in yeast	133
Altering the cap	127
Sensing the air	126
Seeing the retention	121
Assembly-activated aggregation	120
Bacteria lose a pep in their step	113
Determining the role of peroxidation of subcellular lipid membranes in ferroptosis	112
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	109
Facile generation of drug-like conformational antibodies specific for amyloid fibrils	108
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux	107
Engineering eukaryotic transposon-encoded Fanzor2 system for genome editing in mammals	104
Inter-kingdom electromechanical communication	100
E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells	99
Calcium-gated potassium channel blockade via membrane-facing fenestrations	98
A pseudoenzyme enables indole biosynthesis in eudicot plants	97

The landscape of targets and lead molecules for remyelination	92
Programmable living assembly of materials by bacterial adhesion	92
Publisher Correction: Accelerated RNA detection using tandem CRISPR nucleases	91
Small-molecule dissolution of stress granules by redox modulation benefits ALS models	91
Chemigenetic indicators based on synthetic chelators and green fluorescent protein	88
Detecting features of antibody structure through their mediator-accessible redox activities	88
Characterization of a patient-derived variant of GPX4 for precision therapy	87
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates	86
Artificial intelligence foundation for therapeutic science	85
An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation	85
Rationally seeded computational protein design of ɑ-helical barrels	83
A class of anti-inflammatory lipids decrease with aging in the central nervous system	82
ALFA nanobody-guided endogenous labeling	82
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms	82
Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis	81
Seismic shift	79
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability	79
Small-molecule trapping of an RNA-binding protein blocks cancer cell growth	78
The core of the matter	78
Brake disposal	77
Controlling sulfation	77
Running through the blocks	77
Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells	76
M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome	75
Small molecule targeting of chromatin writers in cancer	75
Escherichia coli small molecule metabolism at the host–microorganism interface	74
Open-ended molecular recording of sequential cellular events into DNA	74
Functional profiling of serine, threonine and tyrosine sites	74
Development of an allosteric adhesion GPCR nanobody with therapeutic potential	74
Discovery and molecular basis of subtype-selective cyclophilin inhibitors	73
Structure-based investigation of fluorogenic Pepper aptamer	72
Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II	71
Badminton at nanoscale	70
Peptides hit the catalysis walk	68
Making transient complexes stick	67
Tuned out	67
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins	66
A wrench in the motor	66
Visualizing drug effects over time in live animals using optical pharmacodynamics	65
Endogenous currents in HEK 293 cells are inhibited by memantine	64
Small molecule inhibits KCNQ channels with a non-blocking mechanism	64
Engineering CAR-T cells to activate small-molecule drugs in situ	64
Site-specific encoding of photoactivity and photoreactivity into antibody fragments	64