Cell Metabolism

(The TQCC of Cell Metabolism is 51. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-01-01 to 2024-01-01.)
Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes1080
The Metabolic Underpinnings of Ferroptosis515
Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome461
Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis433
Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer428
AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control396
In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19370
Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis352
Benefits of Metformin in Attenuating the Hallmarks of Aging345
The hallmarks of cancer metabolism: Still emerging304
CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability298
Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation293
Mitochondrial Metabolism as a Target for Cancer Therapy284
The Role of HIF in Immunity and Inflammation271
Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells256
The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation253
Effects of 4- and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity253
Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity227
Amino Assets: How Amino Acids Support Immunity225
Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan213
Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury211
SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment205
The Gut Microbiota in Prediabetes and Diabetes: A Population-Based Cross-Sectional Study205
Exosomes as mediators of intercellular crosstalk in metabolism203
Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention199
Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function197
A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells196
Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization193
An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance192
STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth186
Metabolic-Pathway-Based Subtyping of Triple-Negative Breast Cancer Reveals Potential Therapeutic Targets185
Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice181
Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming180
Ultrasensitive Genetically Encoded Indicator for Hydrogen Peroxide Identifies Roles for the Oxidant in Cell Migration and Mitochondrial Function180
SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition178
Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation171
Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning166
Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming165
SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution163
Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects157
Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism157
The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine155
Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis154
Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity152
Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis152
Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes149
Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease147
Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer’s Disease147
Why does obesity cause diabetes?146
Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress146
FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption144
The Power of Plasticity—Metabolic Regulation of Hepatic Stellate Cells144
Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity143
Gut-Resident Lactobacilli Activate Hepatic Nrf2 and Protect Against Oxidative Liver Injury140
Plasticity of Epididymal Adipose Tissue in Response to Diet-Induced Obesity at Single-Nucleus Resolution139
A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis136
Quantitative Fluxomics of Circulating Metabolites135
Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer133
The Gut Microbiota at the Service of Immunometabolism133
Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy131
SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells128
New Frontiers in the Treatment of Type 1 Diabetes126
Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis125
Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis125
Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19123
Astrocyte-neuron metabolic cooperation shapes brain activity123
Glutamine Links Obesity to Inflammation in Human White Adipose Tissue122
MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice122
Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease120
GDF15 Induces Anorexia through Nausea and Emesis119
Leveraging Human Genetics to Identify Potential New Treatments for Fatty Liver Disease118
Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy118
The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure118
Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance118
Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway116
Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis116
NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion115
The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling114
Serine Catabolism Feeds NADH when Respiration Is Impaired111
Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth110
A High-Density Human Mitochondrial Proximity Interaction Network110
Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers109
Mechanoresponsive metabolism in cancer cell migration and metastasis108
Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2108
The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia108
Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes107
Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis105
Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis103
Insulin Treatment Is Associated with Increased Mortality in Patients with COVID-19 and Type 2 Diabetes101
Immunometabolism in the Single-Cell Era101
Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process100
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context99
Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function99
Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier98
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease95
Hypothalamic detection of macronutrients via multiple gut-brain pathways95
Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage94
Hepatic Lipoprotein Export and Remission of Human Type 2 Diabetes after Weight Loss93
High-fiber diet mitigates maternal obesity-induced cognitive and social dysfunction in the offspring via gut-brain axis93
Current Concepts, Opportunities, and Challenges of Gut Microbiome-Based Personalized Medicine in Nonalcoholic Fatty Liver Disease92
Sphingolipids in metabolic disease: The good, the bad, and the unknown92
When Rhythms Meet the Blues: Circadian Interactions with the Microbiota-Gut-Brain Axis92
Restoring Cellular Energetics Promotes Axonal Regeneration and Functional Recovery after Spinal Cord Injury92
Hyperpolarized MRI of Human Prostate Cancer Reveals Increased Lactate with Tumor Grade Driven by Monocarboxylate Transporter 192
Evolving concepts in NAD+ metabolism91
Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa191
Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain91
Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids91
Molecular aspects of fructose metabolism and metabolic disease90
Gut-liver axis: Pathophysiological concepts and clinical implications88
Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo86
KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease86
Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages86
Efferocytosis induces macrophage proliferation to help resolve tissue injury85
The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer85
Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment84
The Evolving Landscape of Noncanonical Functions of Metabolic Enzymes in Cancer and Other Pathologies84
The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation83
Metabolic orchestration of the wound healing response83
Pyruvate Kinase Controls Signal Strength in the Insulin Secretory Pathway83
Fecal microbiota transplantation in human metabolic diseases: From a murky past to a bright future?82
Mitochondrial signal transduction82
Beta Cell Dedifferentiation Induced by IRE1α Deletion Prevents Type 1 Diabetes80
Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases80
Platelets Facilitate the Wound-Healing Capability of Mesenchymal Stem Cells by Mitochondrial Transfer and Metabolic Reprogramming80
Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis79
Obesity Impairs Short-Term and Working Memory through Gut Microbial Metabolism of Aromatic Amino Acids79
Roles of Regulatory T Cells in Tissue Pathophysiology and Metabolism79
Untangling Determinants of Enhanced Health and Lifespan through a Multi-omics Approach in Mice79
FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake79
Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin78
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist78
A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance77
Warmth Prevents Bone Loss Through the Gut Microbiota77
Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic Steatohepatitis77
Cardiovascular disease in diabetes, beyond glucose76
NTS Catecholamine Neurons Mediate Hypoglycemic Hunger via Medial Hypothalamic Feeding Pathways75
The World Goes Bats: Living Longer and Tolerating Viruses74
The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease74
A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion74
Mitochondrial Oxidative Damage Underlies Regulatory T Cell Defects in Autoimmunity73
Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity72
The Source of Glycolytic Intermediates in Mammalian Tissues72
Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis72
Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing71
Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome71
Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance70
A kidney perspective on the mechanism of action of sodium glucose co-transporter 2 inhibitors70
Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention70
Hypothalamic bile acid-TGR5 signaling protects from obesity70
Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis70
Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction69
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα69
Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis69
The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity69
Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue69
Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation68
Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion68
Mitochondria-Endoplasmic Reticulum Contacts in Reactive Astrocytes Promote Vascular Remodeling67
Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism66
Reducing Hypothalamic Stem Cell Senescence Protects against Aging-Associated Physiological Decline66
CRISPR screens in physiologic medium reveal conditionally essential genes in human cells66
Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication66
The global burden of metabolic disease: Data from 2000 to 201966
Apaf-1 Pyroptosome Senses Mitochondrial Permeability Transition66
GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function65
Sugar-Induced Obesity and Insulin Resistance Are Uncoupled from Shortened Survival in Drosophila64
Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension64
NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis64
Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells64
NAD+ Regeneration Rescues Lifespan, but Not Ataxia, in a Mouse Model of Brain Mitochondrial Complex I Dysfunction64
C9orf72 regulates energy homeostasis by stabilizing mitochondrial complex I assembly64
Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy63
Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly63
A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes63
TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis63
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism62
Microbiota alterations in proline metabolism impact depression61
Meta-hallmarks of aging and cancer61
GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates61
Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition61
LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept61
A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy60
A Metabolic Roadmap for Somatic Stem Cell Fate60
Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding60
“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis60
Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells60
Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis59
The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming59
Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans58
Glial Metabolic Rewiring Promotes Axon Regeneration and Functional Recovery in the Central Nervous System58
Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape58
TAZ Is a Negative Regulator of PPARγ Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance57
The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function57
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity57
The Antioxidant Role of Non-mitochondrial CoQ10: Mystery Solved!56
Senescent immune cells release grancalcin to promote skeletal aging56
Adhesion-mediated mechanosignaling forces mitohormesis56
Creatine promotes cancer metastasis through activation of Smad2/355
TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation55
Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging54
Global Burden of Disease Study 2019 suggests that metabolic risk factors are the leading drivers of the burden of ischemic heart disease54
PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease54
Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells53
Lipids in the Bone Marrow: An Evolving Perspective53
Direct and indirect control of hepatic glucose production by insulin53
The role of lipids in cancer progression and metastasis53
Increased fidelity of protein synthesis extends lifespan52
Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action51
Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer51
Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle51