Cell Metabolism

Article	Citations
Metabolic set points of mammalian neurodevelopment	740
Metabolic elasticity: A new measure of age	590
Early downmodulation of tumor glycolysis predicts response to fasting-mimicking diet in triple-negative breast cancer patients	443
Disrupted methionine cycle triggers muscle atrophy in cancer cachexia through epigenetic regulation of REDD1	442
MARIGOLD and MitoCIAO, two searchable compendia to visualize and functionalize protein complexes during mitochondrial remodeling	417
Formation of I2+III2 supercomplex rescues respiratory chain defects	382
Itaconate boosts malaria via induction of PD-L1	366
The Achilles heel of TNBCs: Ferroptosis heterogeneity	346
Secreted phospholipase A2 modifies extracellular vesicles and accelerates B cell lymphoma	338
Erythrocyte-derived mitochondria take to the lupus stage	327
Walking the high wire: How neurons maintain stability in the crossline of neurodegeneration	316
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle	303
Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK	303
GDF15 is a major determinant of ketogenic diet-induced weight loss	289
PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer	285
A hypometabolic defense strategy against malaria	279
Diabesity? No worries, FKBP11 to the rescue	279
Insulin: A GOAT of medical discovery	274
CoAching CD8+ T cells for tumor immunotherapy—the pantothenate way	270
SARS-CoV-2 pirates the kidneys: A scar(y) story	260
Tirzepatide modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the GIP receptor	256
Nourishing the mind: Fasting for brain health	243
Ketogenesis promotes tolerance to Pseudomonas aeruginosa pulmonary infection	241
Microbial-host isozyme: A novel target in “drug the bug” strategies for diabetes	227
A dietary source of antibiotic tolerance	210

What we talk about when we talk about spinal cord aging	204
Judith Campisi (1948–2024)	203
Nutrients in the fate of pluripotent stem cells	200
Meet the author: Professor Zhijian Cai	197
Methionine restriction forces Epstein-Barr virus out of latency	196
The search for thermoregulatory neurons is heating up	187
Krebs takes a turn at cell differentiation	184
Glycolysis-derived L-serine levels versus PHGDH expression in Alzheimer’s disease	183
Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss	182
Outrunning obesity with Lac-Phe?	182
Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease	179
Bone marrow immune cells stop weight regain	178
Bempedoic acid suppresses diet-induced hepatic steatosis independently of ATP-citrate lyase	178
Gene-metabolite linkage marks stored red blood cell quality	175
Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis	169
Prevention of cardiorenal complications in people with type 2 diabetes and obesity	168
All hands on deck: Adipocytes lept-in to drive nerve regeneration	163
DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication	162
Transforming the cardiometabolic disease landscape: Multimodal AI-powered approaches in prevention and management	161
The effects of pregnancy, its progression, and its cessation on human (maternal) biological aging	158
A new role for ammonia in tumorigenesis?	155
dNTP concentrations do not increase in mammalian cells in response to DNA damage	154
Immunotherapy breaches low-sugar dieting of tumor Treg cells	153
Midlobular zone 2 hepatocytes: A gatekeeper of liver homeostasis	153
Preoptic BRS3 neurons increase body temperature and heart rate via multiple pathways	150
Cap CASP, not SCAP, to fight steatohepatitis	149
Illuminating lactate in cells, mice, and patient samples	149
Fight, flight, and freeze!	141
Death-seq and ye shall find: A novel screening strategy for dying cells	139
Mitochondrial quality control: Just walk away	137
The secret life of lactate: A novel cell-cycle regulatory mechanism	136
Hunger potentiated	134
Complementary lateral hypothalamic populations resist hunger pressure to balance nutritional and social needs	133
Sex- and timing-specific effects of fasting and caloric restriction	133
Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin	133
Adolescent exposure to low-dose THC disrupts energy balance and adipose organ homeostasis in adulthood	133
Dysregulated BH4 metabolism facilitates immunosuppression in pancreatic cancer	129
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis	128
Direct and indirect control of hepatic glucose production by insulin	127
Unveiling adipose populations linked to metabolic health in obesity	122
Palmitoylation couples insulin hypersecretion with β cell failure in diabetes	121
Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma	120
Food colorants metabolized by commensal bacteria promote colitis in mice with dysregulated expression of interleukin-23	119
Mechanoresponsive metabolism in cancer cell migration and metastasis	119
Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration	116
When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging	114
A pattern emerges in chromatin aging: AP-1 steals the show	113
Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis	112
Gut microbial alterations in arginine metabolism determine bone mechanical adaptation	112
Oxylipin-PPARγ-initiated adipocyte senescence propagates secondary senescence in the bone marrow	111

Glycine decarboxylase maintains mitochondrial protein lipoylation to support tumor growth	110
Exercise-induced angiogenesis is dependent on metabolically primed ATF3/4+ endothelial cells	109
Systems-level analysis of insulin action in mouse strains provides insight into tissue- and pathway-specific interactions that drive insulin resistance	109
Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced inflammation	109
Evaluating the beneficial effects of dietary restrictions: A framework for precision nutrigeroscience	109
Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction	107
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial	105
A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis	105
Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression	105
Interferon-α-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity	105
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context	104
Electron transport chain inhibition increases cellular dependence on purine transport and salvage	103
Ketone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding	102
Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells	101
Exploratory physiological experiments are not clinical trials	100
BefA, a microbiota-secreted membrane disrupter, disseminates to the pancreas and increases β cell mass	99
Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise	99
CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression	99
Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation	97
Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila	97
Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity	94
Statins aggravate insulin resistance through reduced blood glucagon-like peptide-1 levels in a microbiota-dependent manner	94
Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity	94
Tyrosine catabolism enhances genotoxic chemotherapy by suppressing translesion DNA synthesis in epithelial ovarian cancer	92
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease	92
Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases	91
MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH	91
The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease	90
NAD precursors cycle between host tissues and the gut microbiome	90
Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer	90
The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits	89
Thymidine kinase 1 drives hepatocellular carcinoma in enzyme-dependent and -independent manners	89
HumanIslets.com: Improving accessibility, integration, and usability of human research islet data	88
The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening	88
Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease	86
Cancer cell-intrinsic XBP1 drives immunosuppressive reprogramming of intratumoral myeloid cells by promoting cholesterol production	85
The pathogenic “symphony” in type 1 diabetes: A disorder of the immune system, β cells, and exocrine pancreas	83
Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging	82
Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators	82
Reactive oxygen species regulation by NCF1 governs ferroptosis susceptibility of Kupffer cells to MASH	81
Sphingolipids in metabolic disease: The good, the bad, and the unknown	81
“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis	81
Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1	80
Discovery, development, and clinical proof of mechanism of LY3463251, a long-acting GDF15 receptor agonist	80
FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity	79
Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities	77
The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming	77
Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages	74
A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1	74
The role of hepatokines in NAFLD	73
Microenvironmental ammonia enhances T cell exhaustion in colorectal cancer	73
Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis	73
A synaptic amplifier of hunger for regaining body weight in the hypothalamus	72
A glimpse at the metabolic research in China	72
Akkermansia muciniphila supplementation in patients with overweight/obese type 2 diabetes: Efficacy depends on its baseline levels in the gut	71
Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming	71
PHGDH expression increases with progression of Alzheimer’s disease pathology and symptoms	70
TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis	70
A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development	70
Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation	70
Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation	69
Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB	69
Worksite-based intensive lifestyle therapy has profound cardiometabolic benefits in people with obesity and type 2 diabetes	68
Activity-balanced GLP-1/GDF15 dual agonist reduces body weight and metabolic disorder in mice and non-human primates	68
Synergistic role of gut-microbial L-ornithine in enhancing ustekinumab efficacy for Crohn’s disease	67
Cellular deconstruction of the human skeletal muscle microenvironment identifies an exercise-induced histaminergic crosstalk	67
Piezo2 in sensory neurons regulates systemic and adipose tissue metabolism	67
Interplay between gut microbial communities and metabolites modulates pan-cancer immunotherapy responses	66
Early immune pressure makes tumors metabolically stronger	66
T-bet B or not T-bet B, is that the question in obesity-related metabolic disease?	66
More than meets the eye: The metabolic state of the body shapes visual sensations	66
Sugar addiction: An Achilles’ heel of auto-immune diseases?	65
GLP-1/GIP/glucagon receptor triagonism gets its try in humans	65
Ketones regulate endothelial homeostasis	64
Advancing de novo lipogenesis: Genetic and metabolic insights	64
Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1	64
Mannose: A game-changer for T cell immunotherapy	63
A new player in the mammalian electron transport chain	62
Multilayered omics reveal sex- and depot-dependent adipose progenitor cell heterogeneity	61
Muscle-derived small extracellular vesicles induce liver fibrosis during overtraining	61

Hepatic stellate cells regulate liver fatty acid utilization via plasmalemma vesicle-associated protein	61
GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism	61
Caloric restriction prevents inheritance of polycystic ovary syndrome through oocyte-mediated DNA methylation reprogramming	61
Microbial metabolite as icebreaker for immunotherapy	60
A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion	60
Kir2.1 channel: Macrophage plasticity in tumor microenvironment	60
A FAsT contribution: Adipocytes rewire their metabolism to acquire immune functions	60
Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues	60
Leptin increases hepatic triglyceride export via a vagal mechanism in humans	60
The how and when of metabolic health	60
Microvessels enhance vascularization and function of transplanted insulin-producing cells	60
Metformin triggers a kidney GDF15-dependent area postrema axis to regulate food intake and body weight	59
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression	59
Restricting mealtime ameliorates neurodegeneration	59
TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver	58
Early-life microbiota as a baby metabolic guardian	58
Thermal facial image analyses reveal quantitative hallmarks of aging and metabolic diseases	58
mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination	58
Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood	58
A sympathetic paradigm shift for the role of NPY in obesity	58
First we eat, then we do everything else: The dynamic metabolic regulation of efferocytosis	57
Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension	57
Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity	57
The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease	57
Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation	56
Mitochondrial fatty acid synthesis is an emergent central regulator of mammalian oxidative metabolism	56
Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage	56
Adhesion-mediated mechanosignaling forces mitohormesis	55
Creatine promotes metastatic dissemination	54
Too much of a good thing: Excess exercise can harm mitochondria	54
Energy saver: Monocytes hibernate in bone marrow upon fasting	53
A neuroimmunometabolic view on the cephalic phase of insulin release	53
Pancreatic beta cell neogenesis: Debates and updates	53
Rejuvenating muscle stem cells with the glutathione system	53
Brains and brawn: Stress-induced myokine abates nervous system aging	53
Quantification of nutrient fluxes during acute exercise in mice	52
Cytosolic calcium regulates hepatic mitochondrial oxidation, intrahepatic lipolysis, and gluconeogenesis via CAMKII activation	52
GLP-1 programs the neurovascular landscape	52
Salty Treg cells get out of balance	51
The cellular supply-side economics for phospholipids	51
Fndc5 is translated from an upstream ATG start codon and cleaved to produce irisin myokine precursor protein in humans and mice	51
The cephalic phase of insulin release is modulated by IL-1β	50
H2S serves as the immunoregulatory essence of apoptotic cell death	49
Targeting metabolic circuitry to supercharge CD8+ T cell antitumor responses	49
ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits	49
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2	49
Sphingolipid metabolism controls mammalian heart regeneration	49
Inflammation and cholesterol at the crossroads of vascular risk	49
Serine and glycine physiology reversibly modulate retinal and peripheral nerve function	49
Endothelial metabolic control of insulin sensitivity through resident macrophages	49