Cell Metabolism

Article	Citations
Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes	1107
The Metabolic Underpinnings of Ferroptosis	586
Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis	460
The hallmarks of cancer metabolism: Still emerging	386
Benefits of Metformin in Attenuating the Hallmarks of Aging	379
In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19	375
Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis	374
CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability	344
Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation	320
Mitochondrial Metabolism as a Target for Cancer Therapy	318
The Role of HIF in Immunity and Inflammation	305
Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells	285
The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation	284
Effects of 4- and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity	277
Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity	269
Exosomes as mediators of intercellular crosstalk in metabolism	256
Amino Assets: How Amino Acids Support Immunity	252
Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan	229
The Gut Microbiota in Prediabetes and Diabetes: A Population-Based Cross-Sectional Study	229
Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization	221
SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment	219
Metabolic-Pathway-Based Subtyping of Triple-Negative Breast Cancer Reveals Potential Therapeutic Targets	210
Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice	199
Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming	198
SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution	194

SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition	192
Why does obesity cause diabetes?	189
Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects	188
Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism	182
The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine	182
Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation	180
Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes	177
Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning	176
Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease	175
The Power of Plasticity—Metabolic Regulation of Hepatic Stellate Cells	172
Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer	167
FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption	166
Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes	164
Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis	164
Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress	161
Plasticity of Epididymal Adipose Tissue in Response to Diet-Induced Obesity at Single-Nucleus Resolution	159
Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity	157
Gut-Resident Lactobacilli Activate Hepatic Nrf2 and Protect Against Oxidative Liver Injury	157
Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease	155
The Gut Microbiota at the Service of Immunometabolism	153
Quantitative Fluxomics of Circulating Metabolites	150
A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis	149
Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis	146
Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy	143
Astrocyte-neuron metabolic cooperation shapes brain activity	139
Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance	137
MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice	136
NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion	135
The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure	133
SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells	132
The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling	129
Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19	128
Mechanoresponsive metabolism in cancer cell migration and metastasis	125
Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2	123
The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia	123
Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth	122
Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy	122
A High-Density Human Mitochondrial Proximity Interaction Network	121
Mitochondrial signal transduction	120
Gut-liver axis: Pathophysiological concepts and clinical implications	120
Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis	118
Serine Catabolism Feeds NADH when Respiration Is Impaired	117
Immunometabolism in the Single-Cell Era	117
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context	116
SARS-CoV-2 infection induces beta cell transdifferentiation	116
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease	115
Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis	114
Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers	114
Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function	110
Evolving concepts in NAD+ metabolism	109

Sphingolipids in metabolic disease: The good, the bad, and the unknown	109
Pseudomonas aeruginosa Utilizes Host-Derived Itaconate to Redirect Its Metabolism to Promote Biofilm Formation	109
Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes	109
Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages	109
High-fiber diet mitigates maternal obesity-induced cognitive and social dysfunction in the offspring via gut-brain axis	108
The global burden of metabolic disease: Data from 2000 to 2019	107
Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process	107
Insulin Treatment Is Associated with Increased Mortality in Patients with COVID-19 and Type 2 Diabetes	105
Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment	104
Molecular aspects of fructose metabolism and metabolic disease	103
The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer	103
Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1	102
KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease	101
Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage	101
Efferocytosis induces macrophage proliferation to help resolve tissue injury	101
Hypothalamic detection of macronutrients via multiple gut-brain pathways	100
Current Concepts, Opportunities, and Challenges of Gut Microbiome-Based Personalized Medicine in Nonalcoholic Fatty Liver Disease	99
Metabolic orchestration of the wound healing response	98
Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy	96
Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain	95
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist	93
The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease	93
Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases	93
Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo	92
Platelets Facilitate the Wound-Healing Capability of Mesenchymal Stem Cells by Mitochondrial Transfer and Metabolic Reprogramming	92
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα	92
The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation	91
Fecal microbiota transplantation in human metabolic diseases: From a murky past to a bright future?	91
The Evolving Landscape of Noncanonical Functions of Metabolic Enzymes in Cancer and Other Pathologies	91
Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue	90
Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin	89
The World Goes Bats: Living Longer and Tolerating Viruses	88
Cardiovascular disease in diabetes, beyond glucose	88
Mitochondria Define Intestinal Stem Cell Differentiation Downstream of a FOXO/Notch Axis	87
Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing	87
Pyruvate Kinase Controls Signal Strength in the Insulin Secretory Pathway	87
Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic Steatohepatitis	86
Untangling Determinants of Enhanced Health and Lifespan through a Multi-omics Approach in Mice	86
Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis	86
A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance	85
The role of lipids in cancer progression and metastasis	85
Warmth Prevents Bone Loss Through the Gut Microbiota	85
Obesity Impairs Short-Term and Working Memory through Gut Microbial Metabolism of Aromatic Amino Acids	84
Beta Cell Dedifferentiation Induced by IRE1α Deletion Prevents Type 1 Diabetes	83
Meta-hallmarks of aging and cancer	82
A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion	81
FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake	80
Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism	80
The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity	80
Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion	80
Hypothalamic bile acid-TGR5 signaling protects from obesity	80
Mitochondrial Oxidative Damage Underlies Regulatory T Cell Defects in Autoimmunity	79
The Neutrophil-to-Lymphocyte Ratio Determines Clinical Efficacy of Corticosteroid Therapy in Patients with COVID-19	79
Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis	78
Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome	78
Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis	78
Mapping the single-cell transcriptomic response of murine diabetic kidney disease to therapies	78
Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis	77
Microbiota alterations in proline metabolism impact depression	77
Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells	77
The Source of Glycolytic Intermediates in Mammalian Tissues	77
Apaf-1 Pyroptosome Senses Mitochondrial Permeability Transition	76
Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation	75
GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function	75
LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept	75
Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance	75
Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity	75
Mitochondria-Endoplasmic Reticulum Contacts in Reactive Astrocytes Promote Vascular Remodeling	75
NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis	75
The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming	74
NAD+ Regeneration Rescues Lifespan, but Not Ataxia, in a Mouse Model of Brain Mitochondrial Complex I Dysfunction	73
Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells	73
Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition	73
A kidney perspective on the mechanism of action of sodium glucose co-transporter 2 inhibitors	73
TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis	73
Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication	72
C9orf72 regulates energy homeostasis by stabilizing mitochondrial complex I assembly	72
CRISPR screens in physiologic medium reveal conditionally essential genes in human cells	72
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism	72
A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy	71

GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates	71
Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction	70
Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans	69
Senescent immune cells release grancalcin to promote skeletal aging	68
“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis	68
Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension	68
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity	68
A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes	68
Sugar-Induced Obesity and Insulin Resistance Are Uncoupled from Shortened Survival in Drosophila	67
The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function	66
A Metabolic Roadmap for Somatic Stem Cell Fate	66
Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape	66
Adhesion-mediated mechanosignaling forces mitohormesis	66
Increased fidelity of protein synthesis extends lifespan	65
Glial Metabolic Rewiring Promotes Axon Regeneration and Functional Recovery in the Central Nervous System	65
Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis	64
Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells	62
Direct and indirect control of hepatic glucose production by insulin	62
Creatine promotes cancer metastasis through activation of Smad2/3	60
TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation	60
Global Burden of Disease Study 2019 suggests that metabolic risk factors are the leading drivers of the burden of ischemic heart disease	60
Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer	59
Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle	59
Distinct properties of adipose stem cell subpopulations determine fat depot-specific characteristics	58
Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging	58
TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation	58
Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia	58
PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease	58
Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma	57
Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer	56
The role of hepatokines in NAFLD	56
Biological age is increased by stress and restored upon recovery	56
Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis	56
Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action	56
Eliminate or reformulate ultra-processed foods? Biological mechanisms matter	55
Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease	55
Circadian rhythms and the gut microbiome synchronize the host’s metabolic response to diet	54
Metabolic stress drives sympathetic neuropathy within the liver	54
Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease	54
The Major Pre- and Postmenopausal Estrogens Play Opposing Roles in Obesity-Driven Mammary Inflammation and Breast Cancer Development	54
OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy	53
Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis	53
Human skeletal muscle CD90+ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients	53
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses	53
Feasibility of time-restricted eating and impacts on cardiometabolic health in 24-h shift workers: The Healthy Heroes randomized control trial	53
Leveraging the Gut to Treat Metabolic Disease	52
Ablation of Fat Cells in Adult Mice Induces Massive Bone Gain	52
Insulin action in adipocytes, adipose remodeling, and systemic effects	52
Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3	52
Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons	51
Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation	51
Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity	51
A methionine-Mettl3-N-methyladenosine axis promotes polycystic kidney disease	51
FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping	50
Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance	50
Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes	50