Cell Metabolism

Article	Citations
Metabolic set points of mammalian neurodevelopment	614
Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation	521
Metabolic elasticity: A new measure of age	374
Bempedoic acid suppresses diet-induced hepatic steatosis independently of ATP-citrate lyase	374
Microbial-host isozyme: A novel target in “drug the bug” strategies for diabetes	338
Death-seq and ye shall find: A novel screening strategy for dying cells	289
BefA, a microbiota-secreted membrane disrupter, disseminates to the pancreas and increases β cell mass	277
Reactive oxygen species regulation by NCF1 governs ferroptosis susceptibility of Kupffer cells to MASH	273
The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening	262
A synaptic amplifier of hunger for regaining body weight in the hypothalamus	259
“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis	258
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context	257
NAD precursors cycle between host tissues and the gut microbiome	250
Erythrocyte-derived mitochondria take to the lupus stage	243
Nourishing the mind: Fasting for brain health	243
Walking the high wire: How neurons maintain stability in the crossline of neurodegeneration	241
Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila	233
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle	232
Immunotherapy breaches low-sugar dieting of tumor Treg cells	223
Illuminating lactate in cells, mice, and patient samples	221
Diabesity? No worries, FKBP11 to the rescue	213
Methionine restriction forces Epstein-Barr virus out of latency	210
A new role for ammonia in tumorigenesis?	204
Cap CASP, not SCAP, to fight steatohepatitis	200
Ketone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding	196

A glimpse at the metabolic research in China	193
Fight, flight, and freeze!	184
Passing on PCOS: new insights into its epigenetic transmission	182
Prevention of cardiorenal complications in people with type 2 diabetes and obesity	173
A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis	173
A hypometabolic defense strategy against malaria	170
Midlobular zone 2 hepatocytes: A gatekeeper of liver homeostasis	165
Global Spread of a Local Fire: Transmission of Endoplasmic Reticulum Stress via Connexin 43	164
Insulin: A GOAT of medical discovery	164
Itaconate boosts malaria via induction of PD-L1	161
Hunger potentiated	160
The secret life of lactate: A novel cell-cycle regulatory mechanism	159
Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis	158
CoAching CD8+ T cells for tumor immunotherapy—the pantothenate way	157
SARS-CoV-2 pirates the kidneys: A scar(y) story	156
A dietary source of antibiotic tolerance	152
Judith Campisi (1948–2024)	150
Gut microbial alterations in arginine metabolism determine bone mechanical adaptation	149
Glycine decarboxylase maintains mitochondrial protein lipoylation to support tumor growth	148
Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis	147
dNTP concentrations do not increase in mammalian cells in response to DNA damage	144
Preoptic BRS3 neurons increase body temperature and heart rate via multiple pathways	144
Nutrients in the fate of pluripotent stem cells	143
Mitochondrial quality control: Just walk away	141
A pattern emerges in chromatin aging: AP-1 steals the show	140
Unveiling adipose populations linked to metabolic health in obesity	139
Meet the author: Professor Zhijian Cai	139
Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans	137
Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging	135
Disrupted methionine cycle triggers muscle atrophy in cancer cachexia through epigenetic regulation of REDD1	133
The search for thermoregulatory neurons is heating up	129
Evaluating the beneficial effects of dietary restrictions: A framework for precision nutrigeroscience	128
Adolescent exposure to low-dose THC disrupts energy balance and adipose organ homeostasis in adulthood	122
Krebs takes a turn at cell differentiation	122
Glycolysis-derived L-serine levels versus PHGDH expression in Alzheimer’s disease	120
FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity	119
The Achilles heel of TNBCs: Ferroptosis heterogeneity	119
Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise	119
Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity	115
Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss	115
Outrunning obesity with Lac-Phe?	114
Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression	113
Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease	112
Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis	112
Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease	109
Electron transport chain inhibition increases cellular dependence on purine transport and salvage	109
Gene-metabolite linkage marks stored red blood cell quality	108
Bone marrow immune cells stop weight regain	108
CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression	107
A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1	106

Tyrosine catabolism enhances genotoxic chemotherapy by suppressing translesion DNA synthesis in epithelial ovarian cancer	106
Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration	101
Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma	99
Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells	98
Discovery, development, and clinical proof of mechanism of LY3463251, a long-acting GDF15 receptor agonist	98
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial	97
Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer	96
The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits	96
The role of hepatokines in NAFLD	96
Oxylipin-PPARγ-initiated adipocyte senescence propagates secondary senescence in the bone marrow	96
The pathogenic “symphony” in type 1 diabetes: A disorder of the immune system, β cells, and exocrine pancreas	95
What we talk about when we talk about spinal cord aging	95
Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1	93
The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming	92
DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication	92
Formation of I2+III2 supercomplex rescues respiratory chain defects	91
Microenvironmental ammonia enhances T cell exhaustion in colorectal cancer	90
Ketogenesis promotes tolerance to Pseudomonas aeruginosa pulmonary infection	90
Food colorants metabolized by commensal bacteria promote colitis in mice with dysregulated expression of interleukin-23	89
Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer	88
Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction	86
When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging	86
Interferon-α-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity	86
Sphingolipids in metabolic disease: The good, the bad, and the unknown	86
Palmitoylation couples insulin hypersecretion with β cell failure in diabetes	86
Sex- and timing-specific effects of fasting and caloric restriction	85
Complementary lateral hypothalamic populations resist hunger pressure to balance nutritional and social needs	85
Direct and indirect control of hepatic glucose production by insulin	84
Secreted phospholipase A2 modifies extracellular vesicles and accelerates B cell lymphoma	84
Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages	83
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease	83
Cancer cell-intrinsic XBP1 drives immunosuppressive reprogramming of intratumoral myeloid cells by promoting cholesterol production	83
Thymidine kinase 1 drives hepatocellular carcinoma in enzyme-dependent and -independent manners	82
Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming	81
Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases	79
Mechanoresponsive metabolism in cancer cell migration and metastasis	78
Exercise-induced angiogenesis is dependent on metabolically primed ATF3/4+ endothelial cells	78
MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH	77
Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced inflammation	77
Apaf-1 Pyroptosome Senses Mitochondrial Permeability Transition	75
Transforming the cardiometabolic disease landscape: Multimodal AI-powered approaches in prevention and management	75
PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer	74
Statins aggravate insulin resistance through reduced blood glucagon-like peptide-1 levels in a microbiota-dependent manner	74
Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin	74
Tirzepatide modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the GIP receptor	71
Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis	70
GDF15 is a major determinant of ketogenic diet-induced weight loss	70
The effects of pregnancy, its progression, and its cessation on human (maternal) biological aging	69
Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators	69
Exploratory physiological experiments are not clinical trials	69
Systems-level analysis of insulin action in mouse strains provides insight into tissue- and pathway-specific interactions that drive insulin resistance	68
Dysregulated BH4 metabolism facilitates immunosuppression in pancreatic cancer	68
Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity	67
Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities	66
The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease	65
All hands on deck: Adipocytes lept-in to drive nerve regeneration	65
Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK	64
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis	64
Early downmodulation of tumor glycolysis predicts response to fasting-mimicking diet in triple-negative breast cancer patients	64
HumanIslets.com: Improving accessibility, integration, and usability of human research islet data	64
Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity	63
Short-term cold exposure induces persistent epigenomic memory in brown fat	62
Inequalities in life expectancy and cardiometabolic disease mortality across and within high-income countries	62
PHGDH expression increases with progression of Alzheimer’s disease pathology and symptoms	61
Supercharging cancer-fighting T cells with lithium carbonate	61
GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism	60
Mitohormesis in Hypothalamic POMC Neurons Mediates Regular Exercise-Induced High-Turnover Metabolism	60
Tanycytes control hypothalamic liraglutide uptake and its anti-obesity actions	60
Activity-balanced GLP-1/GDF15 dual agonist reduces body weight and metabolic disorder in mice and non-human primates	60
A neuroimmunometabolic view on the cephalic phase of insulin release	59
Caloric Restriction Promotes Immunometabolic Reprogramming Leading to Protection from Tuberculosis	59
PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy	59
Early immune pressure makes tumors metabolically stronger	58
T-bet B or not T-bet B, is that the question in obesity-related metabolic disease?	58
More than meets the eye: The metabolic state of the body shapes visual sensations	58
GLP-1/GIP/glucagon receptor triagonism gets its try in humans	57
Sugar addiction: An Achilles’ heel of auto-immune diseases?	57
Low-Calorie Sweeteners with Carbohydrate Do Not Impair Insulin Sensitivity in Humans: Re-analysis Highlighting the Importance of the Comparator	57
Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing	56
Energy saver: Monocytes hibernate in bone marrow upon fasting	56

Salty Treg cells get out of balance	56
Worksite-based intensive lifestyle therapy has profound cardiometabolic benefits in people with obesity and type 2 diabetes	56
Proton pump inhibitor use status does not modify the microbiome signature for cirrhosis	56
Ketones regulate endothelial homeostasis	56
Hypothalamic bile acid-TGR5 signaling protects from obesity	55
Creatine promotes cancer metastasis through activation of Smad2/3	55
A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development	54
Gut bacteria-driven homovanillic acid alleviates depression by modulating synaptic integrity	54
CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability	54
Adhesion-mediated mechanosignaling forces mitohormesis	54
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses	54
Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation	54
The cephalic phase of insulin release is modulated by IL-1β	53
The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity	53
Tryptophan metabolism in health and disease	53
James R. Mitchell (1971–2020)	52
Brains and brawn: Stress-induced myokine abates nervous system aging	52
Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism	52
Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling	51
Immunoediting instructs tumor metabolic reprogramming to support immune evasion	50
Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation	49
A FAsT contribution: Adipocytes rewire their metabolism to acquire immune functions	49
Microvessels enhance vascularization and function of transplanted insulin-producing cells	49
The how and when of metabolic health	49
Creatine promotes metastatic dissemination	49
Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1	48
Plasma protein-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems	48
Hepatic FXR-FGF4 is required for bile acid homeostasis via an FGFR4-LRH-1 signal node under cholestatic stress	48
Advancing de novo lipogenesis: Genetic and metabolic insights	47
Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation	46
Mannose: A game-changer for T cell immunotherapy	46
ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits	46
Central glucagon-like peptide 1 receptor activation inhibits Toll-like receptor agonist-induced inflammation	46
H2S serves as the immunoregulatory essence of apoptotic cell death	46
A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones	46
Neurotransmitters arrive to control systemic autoimmunity	45
Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood	45
Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy	45
Mitochondrial fatty acid synthesis is an emergent central regulator of mammalian oxidative metabolism	45
Inflammation and cholesterol at the crossroads of vascular risk	45
Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure	45
Pancreatic beta cell neogenesis: Debates and updates	44
Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension	44
Treatment regimens may compromise gut-microbiome-derived signatures for liver cirrhosis	44
Too much of a good thing: Excess exercise can harm mitochondria	44
Kir2.1 channel: Macrophage plasticity in tumor microenvironment	44
Microbial metabolite as icebreaker for immunotherapy	44
Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness	43
Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication	43
Multilayered omics reveal sex- and depot-dependent adipose progenitor cell heterogeneity	43
Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state	43
TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver	43
Sphingolipid metabolism controls mammalian heart regeneration	43
The neurocircuitry of fasting-induced glucocorticoid release	43