Cell Metabolism

Article	Citations
Metabolic set points of mammalian neurodevelopment	666
Metabolic elasticity: A new measure of age	551
BefA, a microbiota-secreted membrane disrupter, disseminates to the pancreas and increases β cell mass	402
A synaptic amplifier of hunger for regaining body weight in the hypothalamus	394
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context	338
NAD precursors cycle between host tissues and the gut microbiome	317
Erythrocyte-derived mitochondria take to the lupus stage	289
Walking the high wire: How neurons maintain stability in the crossline of neurodegeneration	278
Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila	277
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle	274
Nourishing the mind: Fasting for brain health	273
Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis	265
Statins aggravate insulin resistance through reduced blood glucagon-like peptide-1 levels in a microbiota-dependent manner	258
GDF15 is a major determinant of ketogenic diet-induced weight loss	257
PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer	247
The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening	243
A pattern emerges in chromatin aging: AP-1 steals the show	242
Tirzepatide modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the GIP receptor	241
Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK	239
Ketone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding	232
Diabesity? No worries, FKBP11 to the rescue	221
Methionine restriction forces Epstein-Barr virus out of latency	218
A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis	206
A hypometabolic defense strategy against malaria	200
Insulin: A GOAT of medical discovery	191

CoAching CD8+ T cells for tumor immunotherapy—the pantothenate way	187
SARS-CoV-2 pirates the kidneys: A scar(y) story	186
Sex- and timing-specific effects of fasting and caloric restriction	182
Complementary lateral hypothalamic populations resist hunger pressure to balance nutritional and social needs	182
Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1	177
Ketogenesis promotes tolerance to Pseudomonas aeruginosa pulmonary infection	174
Judith Campisi (1948–2024)	171
A dietary source of antibiotic tolerance	171
Microbial-host isozyme: A novel target in “drug the bug” strategies for diabetes	171
Gut microbial alterations in arginine metabolism determine bone mechanical adaptation	166
Glycine decarboxylase maintains mitochondrial protein lipoylation to support tumor growth	165
Nutrients in the fate of pluripotent stem cells	164
Meet the author: Professor Zhijian Cai	160
Unveiling adipose populations linked to metabolic health in obesity	159
The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming	156
The search for thermoregulatory neurons is heating up	156
Krebs takes a turn at cell differentiation	155
Glycolysis-derived L-serine levels versus PHGDH expression in Alzheimer’s disease	153
FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity	152
Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise	151
The Achilles heel of TNBCs: Ferroptosis heterogeneity	149
Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss	148
Outrunning obesity with Lac-Phe?	147
Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease	142
Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease	141
Bone marrow immune cells stop weight regain	139
CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression	138
MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH	137
Interferon-α-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity	137
Mitochondrial quality control: Just walk away	125
“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis	125
Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis	122
Hunger potentiated	122
The role of hepatokines in NAFLD	120
Cancer cell-intrinsic XBP1 drives immunosuppressive reprogramming of intratumoral myeloid cells by promoting cholesterol production	119
Adolescent exposure to low-dose THC disrupts energy balance and adipose organ homeostasis in adulthood	119
The pathogenic “symphony” in type 1 diabetes: A disorder of the immune system, β cells, and exocrine pancreas	118
Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging	117
The secret life of lactate: A novel cell-cycle regulatory mechanism	117
Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity	115
Sphingolipids in metabolic disease: The good, the bad, and the unknown	112
Evaluating the beneficial effects of dietary restrictions: A framework for precision nutrigeroscience	109
A new role for ammonia in tumorigenesis?	108
A glimpse at the metabolic research in China	108
dNTP concentrations do not increase in mammalian cells in response to DNA damage	108
Direct and indirect control of hepatic glucose production by insulin	107
Oxylipin-PPARγ-initiated adipocyte senescence propagates secondary senescence in the bone marrow	107
Midlobular zone 2 hepatocytes: A gatekeeper of liver homeostasis	106
Immunotherapy breaches low-sugar dieting of tumor Treg cells	105
Mechanoresponsive metabolism in cancer cell migration and metastasis	105

Preoptic BRS3 neurons increase body temperature and heart rate via multiple pathways	105
Secreted phospholipase A2 modifies extracellular vesicles and accelerates B cell lymphoma	103
Cap CASP, not SCAP, to fight steatohepatitis	100
Illuminating lactate in cells, mice, and patient samples	100
Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration	97
Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer	96
Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators	96
Fight, flight, and freeze!	96
Passing on PCOS: new insights into its epigenetic transmission	96
HumanIslets.com: Improving accessibility, integration, and usability of human research islet data	96
The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease	95
Food colorants metabolized by commensal bacteria promote colitis in mice with dysregulated expression of interleukin-23	94
Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases	94
Death-seq and ye shall find: A novel screening strategy for dying cells	93
Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity	92
Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression	91
Electron transport chain inhibition increases cellular dependence on purine transport and salvage	90
Gene-metabolite linkage marks stored red blood cell quality	90
Bempedoic acid suppresses diet-induced hepatic steatosis independently of ATP-citrate lyase	90
Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis	87
Tyrosine catabolism enhances genotoxic chemotherapy by suppressing translesion DNA synthesis in epithelial ovarian cancer	87
Transforming the cardiometabolic disease landscape: Multimodal AI-powered approaches in prevention and management	86
Prevention of cardiorenal complications in people with type 2 diabetes and obesity	86
DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication	86
The effects of pregnancy, its progression, and its cessation on human (maternal) biological aging	86
All hands on deck: Adipocytes lept-in to drive nerve regeneration	86
A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1	83
Reactive oxygen species regulation by NCF1 governs ferroptosis susceptibility of Kupffer cells to MASH	83
Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma	83
Itaconate boosts malaria via induction of PD-L1	83
Discovery, development, and clinical proof of mechanism of LY3463251, a long-acting GDF15 receptor agonist	82
What we talk about when we talk about spinal cord aging	81
Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer	80
Microenvironmental ammonia enhances T cell exhaustion in colorectal cancer	79
Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells	79
The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits	78
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial	78
Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction	77
When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging	77
Palmitoylation couples insulin hypersecretion with β cell failure in diabetes	75
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease	75
Thymidine kinase 1 drives hepatocellular carcinoma in enzyme-dependent and -independent manners	74
Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages	74
Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming	73
Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced inflammation	70
Exercise-induced angiogenesis is dependent on metabolically primed ATF3/4+ endothelial cells	70
Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin	69
Dysregulated BH4 metabolism facilitates immunosuppression in pancreatic cancer	68
Exploratory physiological experiments are not clinical trials	68
Systems-level analysis of insulin action in mouse strains provides insight into tissue- and pathway-specific interactions that drive insulin resistance	67
Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities	66
MARIGOLD and MitoCIAO, two searchable compendia to visualize and functionalize protein complexes during mitochondrial remodeling	65
Formation of I2+III2 supercomplex rescues respiratory chain defects	64
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis	64
Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation	64
Early downmodulation of tumor glycolysis predicts response to fasting-mimicking diet in triple-negative breast cancer patients	63
Disrupted methionine cycle triggers muscle atrophy in cancer cachexia through epigenetic regulation of REDD1	63
PHGDH expression increases with progression of Alzheimer’s disease pathology and symptoms	62
Worksite-based intensive lifestyle therapy has profound cardiometabolic benefits in people with obesity and type 2 diabetes	61
GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism	61
Activity-balanced GLP-1/GDF15 dual agonist reduces body weight and metabolic disorder in mice and non-human primates	61
Tanycytes control hypothalamic liraglutide uptake and its anti-obesity actions	61
PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy	60
More than meets the eye: The metabolic state of the body shapes visual sensations	60
Early immune pressure makes tumors metabolically stronger	60
T-bet B or not T-bet B, is that the question in obesity-related metabolic disease?	60
Sugar addiction: An Achilles’ heel of auto-immune diseases?	59
GLP-1/GIP/glucagon receptor triagonism gets its try in humans	59
Ketones regulate endothelial homeostasis	58
Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing	58
The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity	57
Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation	57
Microbial metabolite as icebreaker for immunotherapy	57
Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling	56
Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia	56
Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state	56
Immunoediting instructs tumor metabolic reprogramming to support immune evasion	56
A FAsT contribution: Adipocytes rewire their metabolism to acquire immune functions	56
James R. Mitchell (1971–2020)	56
FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption	56

Astrocytic urea cycle detoxifies Aβ-derived ammonia while impairing memory in Alzheimer’s disease	55
Carbon source availability drives nutrient utilization in CD8+ T cells	55
Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis	55
Leptin increases hepatic triglyceride export via a vagal mechanism in humans	54
Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments	54
Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration	54
Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis	53
Region-specific transcriptomic responses to obesity and diabetes in macaque hypothalamus	52
Itaconate impairs immune control of Plasmodium by enhancing mtDNA-mediated PD-L1 expression in monocyte-derived dendritic cells	51
Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage	51
Dual impacts of serine/glycine-free diet in enhancing antitumor immunity and promoting evasion via PD-L1 lactylation	49
Gut-liver axis: Pathophysiological concepts and clinical implications	49
The how and when of metabolic health	49
A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion	49
Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues	49
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer	49
Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB	49
Microvessels enhance vascularization and function of transplanted insulin-producing cells	48
Hepatic FXR-FGF4 is required for bile acid homeostasis via an FGFR4-LRH-1 signal node under cholestatic stress	48
Plasma protein-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems	48
Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation	48
Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure	48
Mitochondrial fatty acid synthesis is an emergent central regulator of mammalian oxidative metabolism	48
Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication	47
Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy	47
Neurotransmitters arrive to control systemic autoimmunity	46
Restricting mealtime ameliorates neurodegeneration	46
Modulation of cancer immunotherapy by dietary fibers and over-the-counter probiotics	46
Kir2.1 channel: Macrophage plasticity in tumor microenvironment	46
First we eat, then we do everything else: The dynamic metabolic regulation of efferocytosis	46
Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species	45
Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation	45
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression	45
Nondigestible stachyose binds membranous HSP90β on small intestinal epithelium to regulate the exosomal miRNAs: A new function and mechanism	45
A kidney perspective on the mechanism of action of sodium glucose co-transporter 2 inhibitors	45
Cellular deconstruction of the human skeletal muscle microenvironment identifies an exercise-induced histaminergic crosstalk	45
A sympathetic paradigm shift for the role of NPY in obesity	44
Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function	44
Metabolic support by macrophages sustains colonic epithelial homeostasis	44
Gut microbiota modulate distal symmetric polyneuropathy in patients with diabetes	44
Short-term cold exposure induces persistent epigenomic memory in brown fat	44
Neutrophils fuel effective immune responses through gluconeogenesis and glycogenesis	43
Early-life microbiota as a baby metabolic guardian	43
Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease	43
Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity	43
mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination	43
An isocaloric moderately high-fat diet extends lifespan in male rats and Drosophila	43
Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation	43
Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia	43
The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease	42
Emerging targetome and signalome landscape of gut microbial metabolites	42
DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing	42
GIPR/GLP-1R dual agonist therapies for diabetes and weight loss—chemistry, physiology, and clinical applications	42
Metformin triggers a kidney GDF15-dependent area postrema axis to regulate food intake and body weight	42
Microbiota alterations in proline metabolism impact depression	42