Cell Metabolism

Article	Citations
The Metabolic Underpinnings of Ferroptosis	656
Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis	486
The hallmarks of cancer metabolism: Still emerging	460
Benefits of Metformin in Attenuating the Hallmarks of Aging	411
CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability	410
Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis	385
In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19	379
Mitochondrial Metabolism as a Target for Cancer Therapy	351
Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation	344
The Role of HIF in Immunity and Inflammation	342
The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation	313
Effects of 4- and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity	301
Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity	298
Exosomes as mediators of intercellular crosstalk in metabolism	291
Amino Assets: How Amino Acids Support Immunity	277
The Gut Microbiota in Prediabetes and Diabetes: A Population-Based Cross-Sectional Study	255
Why does obesity cause diabetes?	246
Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan	243
Metabolic-Pathway-Based Subtyping of Triple-Negative Breast Cancer Reveals Potential Therapeutic Targets	240
SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment	235
Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming	233
SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution	230
Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice	218
Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism	215
Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects	214

SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition	211
The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine	205
Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer	202
Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease	201
FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption	196
Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease	194
Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation	194
Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning	190
Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes	188
The Power of Plasticity—Metabolic Regulation of Hepatic Stellate Cells	187
Astrocyte-neuron metabolic cooperation shapes brain activity	182
Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity	181
Plasticity of Epididymal Adipose Tissue in Response to Diet-Induced Obesity at Single-Nucleus Resolution	180
Quantitative Fluxomics of Circulating Metabolites	176
Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress	175
Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis	175
Gut-liver axis: Pathophysiological concepts and clinical implications	175
Mitochondrial signal transduction	170
The global burden of metabolic disease: Data from 2000 to 2019	168
The Gut Microbiota at the Service of Immunometabolism	163
A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis	161
Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance	160
MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice	156
NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion	147
The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure	145
Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy	145
Mechanoresponsive metabolism in cancer cell migration and metastasis	143
The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling	142
The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia	140
SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells	137
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context	137
Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth	135
Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19	133
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease	133
Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2	129
A High-Density Human Mitochondrial Proximity Interaction Network	128
The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer	128
Sphingolipids in metabolic disease: The good, the bad, and the unknown	127
Efferocytosis induces macrophage proliferation to help resolve tissue injury	125
Evolving concepts in NAD+ metabolism	125
Molecular aspects of fructose metabolism and metabolic disease	125
Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy	125
Meta-hallmarks of aging and cancer	124
Immunometabolism in the Single-Cell Era	124
High-fiber diet mitigates maternal obesity-induced cognitive and social dysfunction in the offspring via gut-brain axis	124
SARS-CoV-2 infection induces beta cell transdifferentiation	123
Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment	121
Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers	120
Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases	119
Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages	119

KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease	119
Metabolic orchestration of the wound healing response	118
The role of lipids in cancer progression and metastasis	118
Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis	118
Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process	118
Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage	116
Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes	116
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα	116
Insulin Treatment Is Associated with Increased Mortality in Patients with COVID-19 and Type 2 Diabetes	112
Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo	107
Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue	106
The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation	106
The Evolving Landscape of Noncanonical Functions of Metabolic Enzymes in Cancer and Other Pathologies	105
Hypothalamic detection of macronutrients via multiple gut-brain pathways	104
Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain	103
Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing	103
Current Concepts, Opportunities, and Challenges of Gut Microbiome-Based Personalized Medicine in Nonalcoholic Fatty Liver Disease	103
Platelets Facilitate the Wound-Healing Capability of Mesenchymal Stem Cells by Mitochondrial Transfer and Metabolic Reprogramming	103
Cardiovascular disease in diabetes, beyond glucose	102
Fecal microbiota transplantation in human metabolic diseases: From a murky past to a bright future?	101
The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease	101
Pyruvate Kinase Controls Signal Strength in the Insulin Secretory Pathway	99
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist	99
Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis	99
Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin	99
Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells	98
Hypothalamic bile acid-TGR5 signaling protects from obesity	97
LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept	97
Mapping the single-cell transcriptomic response of murine diabetic kidney disease to therapies	97
Mitochondria Define Intestinal Stem Cell Differentiation Downstream of a FOXO/Notch Axis	96
Warmth Prevents Bone Loss Through the Gut Microbiota	96
Microbiota alterations in proline metabolism impact depression	94
Untangling Determinants of Enhanced Health and Lifespan through a Multi-omics Approach in Mice	94
The World Goes Bats: Living Longer and Tolerating Viruses	93
Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism	92
NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis	91
Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis	90
Tryptophan metabolism in health and disease	90
Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis	89
FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake	89
Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication	89
The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity	88
Obesity Impairs Short-Term and Working Memory through Gut Microbial Metabolism of Aromatic Amino Acids	87
Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion	87
A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy	87
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism	86
Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis	86
A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance	86
GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates	85
Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome	85
Apaf-1 Pyroptosome Senses Mitochondrial Permeability Transition	85
Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition	85
Mitochondrial Oxidative Damage Underlies Regulatory T Cell Defects in Autoimmunity	84
C9orf72 regulates energy homeostasis by stabilizing mitochondrial complex I assembly	84
The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming	83
TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis	82
The Source of Glycolytic Intermediates in Mammalian Tissues	82
The Neutrophil-to-Lymphocyte Ratio Determines Clinical Efficacy of Corticosteroid Therapy in Patients with COVID-19	81
Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity	80
Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation	80
Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells	80
Senescent immune cells release grancalcin to promote skeletal aging	79
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity	79
CRISPR screens in physiologic medium reveal conditionally essential genes in human cells	79
A kidney perspective on the mechanism of action of sodium glucose co-transporter 2 inhibitors	78
Biological age is increased by stress and restored upon recovery	78
Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance	78
The role of hepatokines in NAFLD	77
Adhesion-mediated mechanosignaling forces mitohormesis	77
NAD+ Regeneration Rescues Lifespan, but Not Ataxia, in a Mouse Model of Brain Mitochondrial Complex I Dysfunction	76
The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function	76
Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension	75
“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis	75
Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis	73
Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging	73
Feasibility of time-restricted eating and impacts on cardiometabolic health in 24-h shift workers: The Healthy Heroes randomized control trial	72
Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction	72
A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes	71
Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape	71
Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans	71

Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells	71
Glial Metabolic Rewiring Promotes Axon Regeneration and Functional Recovery in the Central Nervous System	70
Direct and indirect control of hepatic glucose production by insulin	70
Global Burden of Disease Study 2019 suggests that metabolic risk factors are the leading drivers of the burden of ischemic heart disease	70
Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease	70
OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy	69
Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia	69
Creatine promotes cancer metastasis through activation of Smad2/3	69
Increased fidelity of protein synthesis extends lifespan	68
Circadian rhythms and the gut microbiome synchronize the host’s metabolic response to diet	67
Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis	67
PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease	66
Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer	65
Insulin action in adipocytes, adipose remodeling, and systemic effects	64
Comprehensive single-cell transcriptional profiling defines shared and unique epithelial injury responses during kidney fibrosis	64
Distinct properties of adipose stem cell subpopulations determine fat depot-specific characteristics	63
Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis	63
Human skeletal muscle CD90+ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients	62
Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer	62
Carbon source availability drives nutrient utilization in CD8+ T cells	62
Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action	62
Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma	62
Metabolic stress drives sympathetic neuropathy within the liver	61
Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle	61
Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance	61
TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation	60
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses	60
Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease	59
Metabolic cycles and signals for insulin secretion	59
Ablation of Fat Cells in Adult Mice Induces Massive Bone Gain	59
Eliminate or reformulate ultra-processed foods? Biological mechanisms matter	58
Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3	58
A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation	58
Mitohormesis in Hypothalamic POMC Neurons Mediates Regular Exercise-Induced High-Turnover Metabolism	58
Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation	57
Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity	56
Interferon-α-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity	56
The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy	54
FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping	54
Brain glycogen serves as a critical glucosamine cache required for protein glycosylation	54
Food colorants metabolized by commensal bacteria promote colitis in mice with dysregulated expression of interleukin-23	54
Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial	54
Central Ceramide Signaling Mediates Obesity-Induced Precocious Puberty	53
Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis	53
Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells	53
Local Mitochondrial ATP Production Regulates Endothelial Fatty Acid Uptake and Transport	53
Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging	53
A methionine-Mettl3-N-methyladenosine axis promotes polycystic kidney disease	52
Disulfiram Treatment Normalizes Body Weight in Obese Mice	52
Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity	52
Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction	52
GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment	51
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity	51
Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood	51
Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes	51
MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH	51