Cell Metabolism

Article	Citations
Cap CASP, not SCAP, to fight steatohepatitis	904
Sex- and timing-specific effects of fasting and caloric restriction	575
The secret life of lactate: A novel cell-cycle regulatory mechanism	543
Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction	500
Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity	496
DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication	478
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle	435
The Achilles heel of TNBCs: Ferroptosis heterogeneity	406
Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis	391
“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis	381
Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities	372
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial	337
Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease	336
Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer	320
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis	297
Unveiling adipose populations linked to metabolic health in obesity	260
The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits	254
Microvessels enhance vascularization and function of transplanted insulin-producing cells	238
mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination	229
Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage	227
Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness	226
Mitochondrial membrane lipids in the regulation of bioenergetic flux	225
Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling	213
PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy	208
Sugar addiction: An Achilles’ heel of auto-immune diseases?	205

Kir2.1 channel: Macrophage plasticity in tumor microenvironment	204
Supercharging cancer-fighting T cells with lithium carbonate	200
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2	188
The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury	185
The cephalic phase of insulin release is modulated by IL-1β	184
A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones	184
Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues	180
Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis	177
Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments	174
Sphingolipid metabolism controls mammalian heart regeneration	163
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression	162
A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development	161
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses	158
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH	157
Defend or reproduce? Muscle-derived glutamate determines an immune-reproductive energetic tradeoff	155
Focus on diet and exercise	153
Paraventricular glia drive circuit function to control metabolism	153
Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways	152
Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export	148
Targeting PDAC metabolism: Environment determines what has GOT2 give	144
Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain	144
HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes	142
Understanding the metabolism of infants using whole-body metabolic models	138
Testing the carbohydrate-insulin model: Short-term metabolic responses to consumption of meals with varying glycemic index in healthy adults	137
EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis	136
MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity	134
Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring	132
Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication	130
Early prediction of incident liver disease using conventional risk factors and gut-microbiome-augmented gradient boosting	130
The crosstalk between bone remodeling and energy metabolism: A translational perspective	130
PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders	130
Glutamate metabolism directs energetic trade-offs to shape host-pathogen susceptibility in Drosophila	129
Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism	128
Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial	128
The past, present, and future physiology and pharmacology of glucagon	126
Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation	125
Amino acid is a major carbon source for hepatic lipogenesis	121
Evaluating human genetic support for hypothesized metabolic disease genes	121
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα	120
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells	120
Exosomes as mediators of intercellular crosstalk in metabolism	118
Response to Paik et al. on the disease burden of NAFLD	114
Biting into a union of oncology and metabolism through leukemic stem cells	112
Famsin and fasting adaptation: A glucagon connection	112
Liver microbes controlling immunity: Facts and pitfalls	110
“Shunt-ing” down obesity with novel endogenous metabolites	110
A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation	109
Anti-seizure effects of norepinephrine-induced free fatty acid release	108
Microbiome-derived metabolites counteract tumor-induced immunosuppression and boost immune checkpoint blockade	107
Beggars banquet: Metabolism in the tumor immune microenvironment and cancer therapy	106

Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis	105
Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial	105
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist	104
Understanding the variation in exercise responses to guide personalized physical activity prescriptions	103
Acetate enables metabolic fitness and cognitive performance during sleep disruption	101
Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance	101
Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma	100
Single-cell transcriptomic and spatial landscapes of the developing human pancreas	99
Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies	97
Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment	96
Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1	96
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK	94
Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment	93
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity	92
Emerging therapies in cancer metabolism	92
Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity	92
Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression	90
Deciphering the metabolic heterogeneity of hematopoietic stem cells with single-cell resolution	89
Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging	89
Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma	88
Multi-organ transcriptome atlas of a mouse model of relative energy deficiency in sport	87
Defying “IL-11ness” by inhibiting inflammation: Strategy for health and longevity	87
A nutrigeroscience approach: Dietary macronutrients and cellular senescence	86
Fueling metabolic disruption via FMD to boost chemotherapy in TNBC	86
Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes	84
Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome	84
Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance	84
OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy	83
The Gro3p factor: Restoring NAD+/NADH homeostasis to ameliorate mitochondrial disease	82
FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit	81
Does sweet turn sour? How aspartame aggravates atherosclerosis in a preclinical model	80
GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway	80
Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals	79
Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex	78
Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis	77
The intersection of frailty and metabolism	77
Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability	76
Missed signals: How PET imaging may fail to capture the addictive potential of ultra-processed foods	76
The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency	76
Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism	76
Intracellular infection and immune system cues rewire adipocytes to acquire immune function	75
SLC25A48 controls mitochondrial choline import and metabolism	75
Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling	74
Molecular aspects of fructose metabolism and metabolic disease	74
Preventing metabolic disease: Part I	73
Urea cycle activation triggered by host-microbiota maladaptation driving colorectal tumorigenesis	73
T cells critically depend on pyruvate oxidation	73
Diabetic retinopathy is a ceramidopathy reversible by anti-ceramide immunotherapy	73
Timed feeding aligns the adipocyte clock to optimize thermogenesis when eating a high-fat diet	73
The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy	72
Pyruvate kinase M2 activation reprograms mitochondria in CD8 T cells, enhancing effector functions and efficacy of anti-PD1 therapy	72
Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism	72
The NARly side of whole-body NAD homeostasis	72
Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis	72
Realigned transsulfuration drives BRAF-V600E-targeted therapy resistance in melanoma	71
Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin	71
NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging	71
FGF21 reverses MASH through coordinated actions on the CNS and liver	71
Branching out beyond canonical brown adipocyte function	71
Integrating multiplex immunofluorescent and mass spectrometry imaging to map myeloid heterogeneity in its metabolic and cellular context	71
Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease	70
Hepatocyte CHRNA4 mediates the MASH-promotive effects of immune cell-produced acetylcholine and smoking exposure in mice and humans	70
Age-related ciliopathy: Obesogenic shortening of melanocortin-4 receptor-bearing neuronal primary cilia	69
Not so neutral lipids: Metabolic regulation of the pre-metastatic niche	69
Deoxyhypusine synthase promotes a pro-inflammatory macrophage phenotype	69
Cytosolic pH is a direct nexus in linking environmental cues with insulin processing and secretion in pancreatic β cells	68
Vive la resistant starch: A potential treatment for metabolic dysfunction-associated steatohepatitis	67
Metabolic programs tailor T cell immunity in viral infection, cancer, and aging	65
LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept	65
Unlocking the power of postbiotics: A revolutionary approach to nutrition for humans and animals	65
Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance	64
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity	64
Microbiota-gut-brain axis drives overeating disorders	64
Two independent respiratory chains adapt OXPHOS performance to glycolytic switch	64
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer	64
Genetics-nutrition interactions control diurnal enhancer-promoter dynamics and liver lipid metabolism	63
Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation	63
Fight, flight, and freeze!	63
A pattern emerges in chromatin aging: AP-1 steals the show	63
Krebs takes a turn at cell differentiation	63

Bempedoic acid suppresses diet-induced hepatic steatosis independently of ATP-citrate lyase	63
Diabesity? No worries, FKBP11 to the rescue	63
Thymidine kinase 1 drives hepatocellular carcinoma in enzyme-dependent and -independent manners	62
Gut microbial alterations in arginine metabolism determine bone mechanical adaptation	62
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease	62
Outrunning obesity with Lac-Phe?	61
TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver	61
Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming	61
A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis	61
Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1	61
Targeting metabolic circuitry to supercharge CD8+ T cell antitumor responses	60
Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation	59
A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion	59
Short-term cold exposure induces persistent epigenomic memory in brown fat	59
Leptin enhances the intracellular thyroid hormone activation in skeletal muscle to boost energy balance	59
Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation	59
GLP-1/GIP/glucagon receptor triagonism gets its try in humans	59
Immunoediting instructs tumor metabolic reprogramming to support immune evasion	58
The neurocircuitry of fasting-induced glucocorticoid release	58
Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function	58
Synergistic role of gut-microbial L-ornithine in enhancing ustekinumab efficacy for Crohn’s disease	58
Identification of a molecular resistor that controls UCP1-independent Ca2+ cycling thermogenesis in adipose tissue	58
First we eat, then we do everything else: The dynamic metabolic regulation of efferocytosis	58
T-bet B or not T-bet B, is that the question in obesity-related metabolic disease?	58
Region-specific transcriptomic responses to obesity and diabetes in macaque hypothalamus	57
Hepatic FXR-FGF4 is required for bile acid homeostasis via an FGFR4-LRH-1 signal node under cholestatic stress	57
Inflammation and cholesterol at the crossroads of vascular risk	57
Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1	56
m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1	56
The mitochondrial multi-omic response to exercise training across rat tissues	56
Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state	55
Carbon source availability drives nutrient utilization in CD8+ T cells	55
Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease	54
TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis	54
Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia	53
Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance	53
Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing	53
Peter J. Roach (1948–2022)	53
Making a sPLAsh: The expanding repertoire of EV signaling	52
Eliminate or reformulate ultra-processed foods? Biological mechanisms matter	52
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH	51
Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease	51
GDF15 analogs as obesity therapeutics	51
Non-invasive lipid panel of MASLD fibrosis transition underscores the role of lipoprotein sulfatides in hepatic immunomodulation	51
Acetate controls endothelial-to-mesenchymal transition	51
Circulating glycerate predicts resilience to fructose-induced hepatic steatosis	51
Stress-induced β cell early senescence confers protection against type 1 diabetes	51