Cell Metabolism

Article	Citations
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle	966
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial	633
Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis	559
The secret life of lactate: A novel cell-cycle regulatory mechanism	542
Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities	541
Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease	497
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis	430
Sex- and timing-specific effects of fasting and caloric restriction	408
The Achilles heel of TNBCs: Ferroptosis heterogeneity	401
Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity	375
Cap CASP, not SCAP, to fight steatohepatitis	356
Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer	348
DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication	279
Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction	273
“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis	265
Unveiling adipose populations linked to metabolic health in obesity	251
The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits	250
A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones	243
Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage	225
Kir2.1 channel: Macrophage plasticity in tumor microenvironment	224
Sugar addiction: An Achilles’ heel of auto-immune diseases?	219
Microvessels enhance vascularization and function of transplanted insulin-producing cells	212
mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination	212
Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness	205
Supercharging cancer-fighting T cells with lithium carbonate	201

Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments	197
Sphingolipid metabolism controls mammalian heart regeneration	194
The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury	191
Nutrient allocation fuels T cell-mediated immunity	189
Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling	170
A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development	169
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2	167
Mitochondrial membrane lipids in the regulation of bioenergetic flux	166
The cephalic phase of insulin release is modulated by IL-1β	164
Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues	164
PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy	162
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses	161
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression	161
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH	160
Understanding the metabolism of infants using whole-body metabolic models	155
Testing the carbohydrate-insulin model: Short-term metabolic responses to consumption of meals with varying glycemic index in healthy adults	155
HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes	154
Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain	153
Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication	153
MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity	143
Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring	142
PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders	141
Evaluating human genetic support for hypothesized metabolic disease genes	140
Amino acid is a major carbon source for hepatic lipogenesis	138
Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export	136
Defend or reproduce? Muscle-derived glutamate determines an immune-reproductive energetic tradeoff	133
Paraventricular glia drive circuit function to control metabolism	132
Focus on diet and exercise	131
Targeting PDAC metabolism: Environment determines what has GOT2 give	128
Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism	127
Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways	127
The crosstalk between bone remodeling and energy metabolism: A translational perspective	126
Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation	125
EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis	124
The past, present, and future physiology and pharmacology of glucagon	124
Early prediction of incident liver disease using conventional risk factors and gut-microbiome-augmented gradient boosting	123
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα	122
Glutamate metabolism directs energetic trade-offs to shape host-pathogen susceptibility in Drosophila	120
Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial	118
Famsin and fasting adaptation: A glucagon connection	117
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells	117
“Shunt-ing” down obesity with novel endogenous metabolites	116
Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis	115
Biting into a union of oncology and metabolism through leukemic stem cells	112
Microbiome-derived metabolites counteract tumor-induced immunosuppression and boost immune checkpoint blockade	110
Response to Paik et al. on the disease burden of NAFLD	110
Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance	109
Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma	108
Liver microbes controlling immunity: Facts and pitfalls	107
Anti-seizure effects of norepinephrine-induced free fatty acid release	105

A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation	105
Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment	103
Beggars banquet: Metabolism in the tumor immune microenvironment and cancer therapy	102
Understanding the variation in exercise responses to guide personalized physical activity prescriptions	102
Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1	101
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity	98
Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies	97
Deciphering the metabolic heterogeneity of hematopoietic stem cells with single-cell resolution	97
Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression	97
Single-cell transcriptomic and spatial landscapes of the developing human pancreas	97
Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial	96
Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging	96
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist	93
Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma	92
Emerging therapies in cancer metabolism	91
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK	91
Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment	90
Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity	90
Acetate enables metabolic fitness and cognitive performance during sleep disruption	90
Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism	88
FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit	88
Does sweet turn sour? How aspartame aggravates atherosclerosis in a preclinical model	88
Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability	87
Missed signals: How PET imaging may fail to capture the addictive potential of ultra-processed foods	86
Defying “IL-11ness” by inhibiting inflammation: Strategy for health and longevity	86
GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway	86
Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals	86
Multi-organ transcriptome atlas of a mouse model of relative energy deficiency in sport	85
Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex	85
The intersection of frailty and metabolism	85
Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome	84
SLC25A48 controls mitochondrial choline import and metabolism	83
Diabetic retinopathy is a ceramidopathy reversible by anti-ceramide immunotherapy	82
A nutrigeroscience approach: Dietary macronutrients and cellular senescence	82
Intracellular infection and immune system cues rewire adipocytes to acquire immune function	82
Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes	81
Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance	81
Fueling metabolic disruption via FMD to boost chemotherapy in TNBC	80
Urea cycle activation triggered by host-microbiota maladaptation driving colorectal tumorigenesis	80
Molecular aspects of fructose metabolism and metabolic disease	79
The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency	79
OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy	79
Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling	79
Branching out beyond canonical brown adipocyte function	78
Preventing metabolic disease: Part I	78
The NARly side of whole-body NAD homeostasis	78
Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin	77
Integrating multiplex immunofluorescent and mass spectrometry imaging to map myeloid heterogeneity in its metabolic and cellular context	77
Realigned transsulfuration drives BRAF-V600E-targeted therapy resistance in melanoma	76
Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism	76
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity	76
Two independent respiratory chains adapt OXPHOS performance to glycolytic switch	76
Cytosolic pH is a direct nexus in linking environmental cues with insulin processing and secretion in pancreatic β cells	76
Not so neutral lipids: Metabolic regulation of the pre-metastatic niche	75
Hepatocyte CHRNA4 mediates the MASH-promotive effects of immune cell-produced acetylcholine and smoking exposure in mice and humans	75
Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease	75
Vive la resistant starch: A potential treatment for metabolic dysfunction-associated steatohepatitis	75
Metabolic programs tailor T cell immunity in viral infection, cancer, and aging	75
Microbiota-gut-brain axis drives overeating disorders	75
Timed feeding aligns the adipocyte clock to optimize thermogenesis when eating a high-fat diet	74
Age-related ciliopathy: Obesogenic shortening of melanocortin-4 receptor-bearing neuronal primary cilia	74
FGF21 reverses MASH through coordinated actions on the CNS and liver	72
Paternal exercise confers endurance capacity to offspring through sperm microRNAs	72
NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging	71
Unlocking the power of postbiotics: A revolutionary approach to nutrition for humans and animals	70
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer	70
LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept	69
A pattern emerges in chromatin aging: AP-1 steals the show	69
Pyruvate kinase M2 activation reprograms mitochondria in CD8 T cells, enhancing effector functions and efficacy of anti-PD1 therapy	69
Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance	69
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease	68
Genetics-nutrition interactions control diurnal enhancer-promoter dynamics and liver lipid metabolism	68
Gut microbial alterations in arginine metabolism determine bone mechanical adaptation	68
Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation	68
Diabesity? No worries, FKBP11 to the rescue	67
Krebs takes a turn at cell differentiation	67
Thymidine kinase 1 drives hepatocellular carcinoma in enzyme-dependent and -independent manners	67
Bempedoic acid suppresses diet-induced hepatic steatosis independently of ATP-citrate lyase	66
Fight, flight, and freeze!	66
Targeting metabolic circuitry to supercharge CD8+ T cell antitumor responses	65

Outrunning obesity with Lac-Phe?	65
Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1	65
A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis	65
A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion	64
Synergistic role of gut-microbial L-ornithine in enhancing ustekinumab efficacy for Crohn’s disease	64
Inflammation and cholesterol at the crossroads of vascular risk	64
T-bet B or not T-bet B, is that the question in obesity-related metabolic disease?	64
GLP-1/GIP/glucagon receptor triagonism gets its try in humans	64
The neurocircuitry of fasting-induced glucocorticoid release	63
Immunoediting instructs tumor metabolic reprogramming to support immune evasion	63
The mitochondrial multi-omic response to exercise training across rat tissues	63
TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver	62
Short-term cold exposure induces persistent epigenomic memory in brown fat	62
Leptin enhances the intracellular thyroid hormone activation in skeletal muscle to boost energy balance	62
m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1	62
First we eat, then we do everything else: The dynamic metabolic regulation of efferocytosis	60
Carbon source availability drives nutrient utilization in CD8+ T cells	60
Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia	60
TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis	60
Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation	60
Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function	60
Hepatic FXR-FGF4 is required for bile acid homeostasis via an FGFR4-LRH-1 signal node under cholestatic stress	59
Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state	59
Region-specific transcriptomic responses to obesity and diabetes in macaque hypothalamus	59
Identification of a molecular resistor that controls UCP1-independent Ca2+ cycling thermogenesis in adipose tissue	59
Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing	58
Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance	58
Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease	58
Reassessment of antibody-based detection of the murine T cell GLP-1 receptor	58
Eliminate or reformulate ultra-processed foods? Biological mechanisms matter	58
Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1	58
Circulating glycerate predicts resilience to fructose-induced hepatic steatosis	58
Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST	58
Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation	58
Transcriptomic, epigenomic, and spatial metabolomic cell profiling redefines regional human kidney anatomy	57
Making a sPLAsh: The expanding repertoire of EV signaling	57
GDF15 analogs as obesity therapeutics	57
Stress-induced β cell early senescence confers protection against type 1 diabetes	56
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH	56
Peter J. Roach (1948–2022)	56
Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease	56
Acetate controls endothelial-to-mesenchymal transition	56
Non-invasive lipid panel of MASLD fibrosis transition underscores the role of lipoprotein sulfatides in hepatic immunomodulation	56