Cell Metabolism

Article	Citations
The Metabolic Underpinnings of Ferroptosis	706
The hallmarks of cancer metabolism: Still emerging	520
Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis	510
CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability	446
Mitochondrial Metabolism as a Target for Cancer Therapy	372
The Role of HIF in Immunity and Inflammation	365
The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation	331
Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity	328
Effects of 4- and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity	322
Exosomes as mediators of intercellular crosstalk in metabolism	317
Why does obesity cause diabetes?	282
The Gut Microbiota in Prediabetes and Diabetes: A Population-Based Cross-Sectional Study	275
Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming	255
Metabolic-Pathway-Based Subtyping of Triple-Negative Breast Cancer Reveals Potential Therapeutic Targets	252
SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment	252
SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution	248
Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease	237
Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice	230
Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects	225
Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism	225
Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer	223
The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine	223
SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition	222
Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease	219
FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption	214

Gut-liver axis: Pathophysiological concepts and clinical implications	213
Astrocyte-neuron metabolic cooperation shapes brain activity	202
Mitochondrial signal transduction	201
The global burden of metabolic disease: Data from 2000 to 2019	199
Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes	199
The Power of Plasticity—Metabolic Regulation of Hepatic Stellate Cells	196
Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning	193
Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity	192
Quantitative Fluxomics of Circulating Metabolites	188
Plasticity of Epididymal Adipose Tissue in Response to Diet-Induced Obesity at Single-Nucleus Resolution	187
Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis	185
Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance	175
The Gut Microbiota at the Service of Immunometabolism	171
A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis	170
Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy	166
MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice	163
Mechanoresponsive metabolism in cancer cell migration and metastasis	157
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context	155
NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion	155
Meta-hallmarks of aging and cancer	154
The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling	153
The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia	152
Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth	152
The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure	150
The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer	145
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease	143
SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells	140
Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2	139
The role of lipids in cancer progression and metastasis	139
High-fiber diet mitigates maternal obesity-induced cognitive and social dysfunction in the offspring via gut-brain axis	139
Efferocytosis induces macrophage proliferation to help resolve tissue injury	138
Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19	136
Molecular aspects of fructose metabolism and metabolic disease	136
Metabolic orchestration of the wound healing response	136
A High-Density Human Mitochondrial Proximity Interaction Network	136
Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages	135
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα	135
Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases	134
Sphingolipids in metabolic disease: The good, the bad, and the unknown	134
Evolving concepts in NAD+ metabolism	133
KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease	132
Immunometabolism in the Single-Cell Era	131
Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment	130
Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy	129
Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers	129
SARS-CoV-2 infection induces beta cell transdifferentiation	126
Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process	123
Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing	121
Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis	117
The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease	117

Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes	116
Tryptophan metabolism in health and disease	116
Platelets Facilitate the Wound-Healing Capability of Mesenchymal Stem Cells by Mitochondrial Transfer and Metabolic Reprogramming	115
Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo	114
Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue	114
The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation	113
Insulin Treatment Is Associated with Increased Mortality in Patients with COVID-19 and Type 2 Diabetes	112
Hypothalamic detection of macronutrients via multiple gut-brain pathways	111
The Evolving Landscape of Noncanonical Functions of Metabolic Enzymes in Cancer and Other Pathologies	111
Fecal microbiota transplantation in human metabolic diseases: From a murky past to a bright future?	109
LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept	108
Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells	108
Current Concepts, Opportunities, and Challenges of Gut Microbiome-Based Personalized Medicine in Nonalcoholic Fatty Liver Disease	106
Cardiovascular disease in diabetes, beyond glucose	106
Mapping the single-cell transcriptomic response of murine diabetic kidney disease to therapies	106
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist	104
Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin	103
Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis	103
Microbiota alterations in proline metabolism impact depression	103
Warmth Prevents Bone Loss Through the Gut Microbiota	103
Pyruvate Kinase Controls Signal Strength in the Insulin Secretory Pathway	102
Hypothalamic bile acid-TGR5 signaling protects from obesity	102
NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis	101
Mitochondria Define Intestinal Stem Cell Differentiation Downstream of a FOXO/Notch Axis	100
Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis	98
The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity	97
Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism	96
Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication	96
Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition	95
Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis	94
The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming	94
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism	93
A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy	93
Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion	93
The role of hepatokines in NAFLD	92
Obesity Impairs Short-Term and Working Memory through Gut Microbial Metabolism of Aromatic Amino Acids	92
Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis	92
Apaf-1 Pyroptosome Senses Mitochondrial Permeability Transition	91
Biological age is increased by stress and restored upon recovery	90
A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance	90
GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates	90
Senescent immune cells release grancalcin to promote skeletal aging	89
TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis	88
Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells	88
The Neutrophil-to-Lymphocyte Ratio Determines Clinical Efficacy of Corticosteroid Therapy in Patients with COVID-19	87
The Source of Glycolytic Intermediates in Mammalian Tissues	87
Mitochondrial Oxidative Damage Underlies Regulatory T Cell Defects in Autoimmunity	87
CRISPR screens in physiologic medium reveal conditionally essential genes in human cells	86
A kidney perspective on the mechanism of action of sodium glucose co-transporter 2 inhibitors	85
C9orf72 regulates energy homeostasis by stabilizing mitochondrial complex I assembly	85
Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance	85
Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation	84
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity	83
The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function	83
Comprehensive single-cell transcriptional profiling defines shared and unique epithelial injury responses during kidney fibrosis	82
Adhesion-mediated mechanosignaling forces mitohormesis	82
Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging	82
Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia	82
Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension	81
Feasibility of time-restricted eating and impacts on cardiometabolic health in 24-h shift workers: The Healthy Heroes randomized control trial	80
“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis	79
Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis	79
Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells	77
Glial Metabolic Rewiring Promotes Axon Regeneration and Functional Recovery in the Central Nervous System	77
Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans	77
Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance	77
OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy	76
Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease	76
Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape	76
Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity	76
Creatine promotes cancer metastasis through activation of Smad2/3	75
A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes	74
Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis	74
Increased fidelity of protein synthesis extends lifespan	73
Global Burden of Disease Study 2019 suggests that metabolic risk factors are the leading drivers of the burden of ischemic heart disease	73
Direct and indirect control of hepatic glucose production by insulin	73
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses	72
PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease	71
Circadian rhythms and the gut microbiome synchronize the host’s metabolic response to diet	69
Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer	69

Carbon source availability drives nutrient utilization in CD8+ T cells	69
Insulin action in adipocytes, adipose remodeling, and systemic effects	69
Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle	69
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity	68
Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis	67
Distinct properties of adipose stem cell subpopulations determine fat depot-specific characteristics	67
Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action	66
Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer	66
Human skeletal muscle CD90+ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients	65
Metabolic stress drives sympathetic neuropathy within the liver	65
Metabolic cycles and signals for insulin secretion	64
TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation	64
Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma	64
Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease	63
Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3	63
Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial	62
Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation	62
A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation	62
Interferon-α-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity	61
GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment	61
Ablation of Fat Cells in Adult Mice Induces Massive Bone Gain	61
Mitohormesis in Hypothalamic POMC Neurons Mediates Regular Exercise-Induced High-Turnover Metabolism	60
Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity	60
Eliminate or reformulate ultra-processed foods? Biological mechanisms matter	59
FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping	59
Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood	58
Central Ceramide Signaling Mediates Obesity-Induced Precocious Puberty	57
Metabolic programs tailor T cell immunity in viral infection, cancer, and aging	56
Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction	56
A methionine-Mettl3-N-methyladenosine axis promotes polycystic kidney disease	56
Food colorants metabolized by commensal bacteria promote colitis in mice with dysregulated expression of interleukin-23	56
The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy	56
Brain glycogen serves as a critical glucosamine cache required for protein glycosylation	56
Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging	55
Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells	54
A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells	54
Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis	54
Hyodeoxycholic acid alleviates non-alcoholic fatty liver disease through modulating the gut-liver axis	53
A newly identified protein from Akkermansia muciniphila stimulates GLP-1 secretion	53
Fatty acid overproduction by gut commensal microbiota exacerbates obesity	53
Aging Reprograms the Hematopoietic-Vascular Niche to Impede Regeneration and Promote Fibrosis	53
Late isocaloric eating increases hunger, decreases energy expenditure, and modifies metabolic pathways in adults with overweight and obesity	53
Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health	52
Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression	52
MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH	52
IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2	52
FGF1 and insulin control lipolysis by convergent pathways	51
Multi-Tissue Acceleration of the Mitochondrial Phosphoenolpyruvate Cycle Improves Whole-Body Metabolic Health	51
Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes	51
Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila	51
The crosstalk between bone remodeling and energy metabolism: A translational perspective	50
Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer	50
Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1	50
Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism	49
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial	49
Adipose tissue at single-cell resolution	49