Cell Metabolism

Article	Citations
The secret life of lactate: A novel cell-cycle regulatory mechanism	771
Cap CASP, not SCAP, to fight steatohepatitis	611
Sex- and timing-specific effects of fasting and caloric restriction	464
The Achilles heel of TNBCs: Ferroptosis heterogeneity	460
Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease	436
The search for thermoregulatory neurons is heating up	401
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle	388
Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity	356
Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis	353
Unveiling adipose populations linked to metabolic health in obesity	343
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial	342
Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer	313
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis	311
Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity	307
“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis	297
Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities	290
The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits	282
DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication	280
Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction	265
mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination	262
A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones	258
The cephalic phase of insulin release is modulated by IL-1β	253
Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis	231
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression	222
Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling	211

Microvessels enhance vascularization and function of transplanted insulin-producing cells	210
Creatine promotes metastatic dissemination	205
Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage	189
Kir2.1 channel: Macrophage plasticity in tumor microenvironment	189
Sugar addiction: An Achilles’ heel of auto-immune diseases?	189
Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues	187
A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development	187
Supercharging cancer-fighting T cells with lithium carbonate	187
Sphingolipid metabolism controls mammalian heart regeneration	182
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2	181
Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments	175
Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth	174
FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption	171
Mitochondrial membrane lipids in the regulation of bioenergetic flux	170
Adhesion-mediated mechanosignaling forces mitohormesis	169
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses	165
PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy	162
Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring	161
Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness	161
MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity	160
EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis	154
Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain	153
Early prediction of incident liver disease using conventional risk factors and gut-microbiome-augmented gradient boosting	150
Glutamate metabolism directs energetic trade-offs to shape host-pathogen susceptibility in Drosophila	150
Evaluating human genetic support for hypothesized metabolic disease genes	149
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH	146
Amino acid is a major carbon source for hepatic lipogenesis	143
Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation	141
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells	139
Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export	137
Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways	137
PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders	136
Understanding the metabolism of infants using whole-body metabolic models	135
Defend or reproduce? Muscle-derived glutamate determines an immune-reproductive energetic tradeoff	134
Paraventricular glia drive circuit function to control metabolism	132
Focus on diet and exercise	127
Mitochondria ensure immune surveillance by retro-communication with the nucleus	124
Targeting PDAC metabolism: Environment determines what has GOT2 give	124
The crosstalk between bone remodeling and energy metabolism: A translational perspective	123
Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial	121
The past, present, and future physiology and pharmacology of glucagon	121
Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism	121
Testing the carbohydrate-insulin model: Short-term metabolic responses to consumption of meals with varying glycemic index in healthy adults	119
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα	118
Exosomes as mediators of intercellular crosstalk in metabolism	117
Microbiome-derived metabolites counteract tumor-induced immunosuppression and boost immune checkpoint blockade	116
Response to Paik et al. on the disease burden of NAFLD	116
Biting into a union of oncology and metabolism through leukemic stem cells	115
Anti-seizure effects of norepinephrine-induced free fatty acid release	114
A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation	111

Can tumor cells take it all away?	111
Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance	110
Famsin and fasting adaptation: A glucagon connection	110
Understanding the variation in exercise responses to guide personalized physical activity prescriptions	109
“Shunt-ing” down obesity with novel endogenous metabolites	109
Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression	108
Cardiovascular disease in diabetes, beyond glucose	107
Liver microbes controlling immunity: Facts and pitfalls	107
Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma	106
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK	104
Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1	102
Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging	102
Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma	101
Emerging therapies in cancer metabolism	101
Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment	99
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity	98
Acetate enables metabolic fitness and cognitive performance during sleep disruption	97
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist	96
Deciphering the metabolic heterogeneity of hematopoietic stem cells with single-cell resolution	96
Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial	94
Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment	93
Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity	92
Single-cell transcriptomic and spatial landscapes of the developing human pancreas	92
Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies	91
Beggars banquet: Metabolism in the tumor immune microenvironment and cancer therapy	91
SLC25A48 controls mitochondrial choline import and metabolism	91
Defying “IL-11ness” by inhibiting inflammation: Strategy for health and longevity	89
The Gro3p factor: Restoring NAD+/NADH homeostasis to ameliorate mitochondrial disease	89
Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling	88
Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes	85
Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome	85
Fueling metabolic disruption via FMD to boost chemotherapy in TNBC	84
Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals	83
Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism	83
Multi-organ transcriptome atlas of a mouse model of relative energy deficiency in sport	83
Intracellular infection and immune system cues rewire adipocytes to acquire immune function	82
The intersection of frailty and metabolism	81
Top-down control of conditioned overconsumption is mediated by insular cortex Nos1 neurons	81
GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway	81
FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit	80
Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance	79
Diabetic retinopathy is a ceramidopathy reversible by anti-ceramide immunotherapy	79
Molecular aspects of fructose metabolism and metabolic disease	78
Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex	76
OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy	76
Urea cycle activation triggered by host-microbiota maladaptation driving colorectal tumorigenesis	76
Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability	74
A nutrigeroscience approach: Dietary macronutrients and cellular senescence	74
The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency	74
Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis	74
Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism	73
Not so neutral lipids: Metabolic regulation of the pre-metastatic niche	72
Branching out beyond canonical brown adipocyte function	71
Preventing metabolic disease: Part I	71
Realigned transsulfuration drives BRAF-V600E-targeted therapy resistance in melanoma	71
Vive la resistant starch: A potential treatment for metabolic dysfunction-associated steatohepatitis	70
T cells critically depend on pyruvate oxidation	70
Cytosolic pH is a direct nexus in linking environmental cues with insulin processing and secretion in pancreatic β cells	70
Timed feeding aligns the adipocyte clock to optimize thermogenesis when eating a high-fat diet	70
Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin	69
Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis	69
Pyruvate kinase M2 activation reprograms mitochondria in CD8 T cells, enhancing effector functions and efficacy of anti-PD1 therapy	69
Microbiota-gut-brain axis drives overeating disorders	68
Two independent respiratory chains adapt OXPHOS performance to glycolytic switch	67
Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease	67
Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance	67
The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy	67
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity	66
NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging	66
Integrating multiplex immunofluorescent and mass spectrometry imaging to map myeloid heterogeneity in its metabolic and cellular context	66
Deoxyhypusine synthase promotes a pro-inflammatory macrophage phenotype	66
Age-related ciliopathy: Obesogenic shortening of melanocortin-4 receptor-bearing neuronal primary cilia	66
Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation	65
The therapeutic promises of NAD+ boosters	65
LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept	64
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer	64
Unlocking the power of postbiotics: A revolutionary approach to nutrition for humans and animals	64
Hepatocyte CHRNA4 mediates the MASH-promotive effects of immune cell-produced acetylcholine and smoking exposure in mice and humans	64
Fight, flight, and freeze!	62
Metabolic programs tailor T cell immunity in viral infection, cancer, and aging	62

Bempedoic acid suppresses diet-induced hepatic steatosis independently of ATP-citrate lyase	62
SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment	62
A dietary source of antibiotic tolerance	61
Gut microbial alterations in arginine metabolism determine bone mechanical adaptation	61
Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation	61
A pattern emerges in chromatin aging: AP-1 steals the show	61
Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging	61
Diabesity? No worries, FKBP11 to the rescue	61
Krebs takes a turn at cell differentiation	61
Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1	60
Outrunning obesity with Lac-Phe?	60
Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming	60
A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis	60
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease	60
Thymidine kinase 1 drives hepatocellular carcinoma in enzyme-dependent and -independent manners	60
TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver	58
T-bet B or not T-bet B, is that the question in obesity-related metabolic disease?	58
The neurocircuitry of fasting-induced glucocorticoid release	58
GLP-1/GIP/glucagon receptor triagonism gets its try in humans	58
Synergistic role of gut-microbial L-ornithine in enhancing ustekinumab efficacy for Crohn’s disease	57
Identification of a molecular resistor that controls UCP1-independent Ca2+ cycling thermogenesis in adipose tissue	57
Leptin enhances the intracellular thyroid hormone activation in skeletal muscle to boost energy balance	57
Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function	57
A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion	57
Short-term cold exposure induces persistent epigenomic memory in brown fat	56
Inflammation and cholesterol at the crossroads of vascular risk	56
m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1	56
First we eat, then we do everything else: The dynamic metabolic regulation of efferocytosis	54
The mitochondrial multi-omic response to exercise training across rat tissues	54
Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease	54
Targeting metabolic circuitry to supercharge CD8+ T cell antitumor responses	54
Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation	53
Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation	53
TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis	53
Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing	53
Creatine promotes cancer metastasis through activation of Smad2/3	53
Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1	52
Carbon source availability drives nutrient utilization in CD8+ T cells	52
Region-specific transcriptomic responses to obesity and diabetes in macaque hypothalamus	52
Peter J. Roach (1948–2022)	50
Hepatic FXR-FGF4 is required for bile acid homeostasis via an FGFR4-LRH-1 signal node under cholestatic stress	50
GDF15 analogs as obesity therapeutics	50
Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia	50
Immunoediting instructs tumor metabolic reprogramming to support immune evasion	50
Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state	50
Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST	49
Making a sPLAsh: The expanding repertoire of EV signaling	49
Transcriptomic, epigenomic, and spatial metabolomic cell profiling redefines regional human kidney anatomy	49
Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance	49
Circulating glycerate predicts resilience to fructose-induced hepatic steatosis	49
Exercise induces tissue-specific adaptations to enhance cardiometabolic health	48
Non-invasive lipid panel of MASLD fibrosis transition underscores the role of lipoprotein sulfatides in hepatic immunomodulation	48
Stress-induced β cell early senescence confers protection against type 1 diabetes	48
Eliminate or reformulate ultra-processed foods? Biological mechanisms matter	48
Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease	48
Acetate controls endothelial-to-mesenchymal transition	47
Deoxyribonucleoside triphosphate pools in mammalian cells are expandable upon DNA damage	47
Individual-specific functional epigenomics reveals genetic determinants of adverse metabolic effects of glucocorticoids	47
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH	47
Glucocorticoid resistance and hyperlactatemia: A tag team to worsen sepsis	47
SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression	46
Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes	46
The DEAD Box Protein Mrh4 Functions in the Assembly of the Mitochondrial Large Ribosomal Subunit	46
Protection from alcohol intoxication: Must be FGF21 to enter	46
She didn’t start the fire: Mammary duct epithelial cells suppress adipocyte thermogenesis	46
A distinct hypothalamus-to-β cell circuit modulates insulin secretion	45
Separate gut-brain circuits for fat and sugar reinforcement combine to promote overeating	45
Can we talk? The cryptic communications of hepatic stellate cells in lipid metabolism	45
Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples	45
Mitohormesis	45
A purine metabolic checkpoint that prevents autoimmunity and autoinflammation	45
FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity	45
Physiologic disruption and metabolic reprogramming in infection and sepsis	44
The browning and mobilization of subcutaneous white adipose tissue supports efficient skin repair	44
The mitochondrial unfolded protein response regulates hippocampal neural stem cell aging	44
Feasibility of time-restricted eating and impacts on cardiometabolic health in 24-h shift workers: The Healthy Heroes randomized control trial	44
Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection	43
Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity	43
NSUN2 is a glucose sensor suppressing cGAS/STING to maintain tumorigenesis and immunotherapy resistance	42
Colonic macrophages eat and feed	42
Embracing the unknown: Proteomic insights into the human microbiome	42
Fecal microbiota transplantation in human metabolic diseases: From a murky past to a bright future?	42
SREBP1c-PARP1 axis tunes anti-senescence activity of adipocytes and ameliorates metabolic imbalance in obesity	42
The effects of obesity and metabolic abnormalities on severe COVID-19-related outcomes after vaccination: A population-based study	42
Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice	42
Extracellular HSP90 warms up integrins for an irisin workout	42
Multi-omic human pancreatic islet endoplasmic reticulum and cytokine stress response mapping provides type 2 diabetes genetic insights	42
Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment	41
The hormesis principle of neuroplasticity and neuroprotection	41
PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2	41
Dysfunctional circadian clock accelerates cancer metastasis by intestinal microbiota triggering accumulation of myeloid-derived suppressor cells	41
Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2	41
Impact of biological sex and sex hormones on molecular signatures of skeletal muscle at rest and in response to distinct exercise training modes	41
Molecular and metabolic heterogeneity of astrocytes and microglia	41
Meta-hallmarks of aging and cancer	40