Cell Metabolism

Papers
(The median citation count of Cell Metabolism is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)
ArticleCitations
The secret life of lactate: A novel cell-cycle regulatory mechanism771
Cap CASP, not SCAP, to fight steatohepatitis611
Sex- and timing-specific effects of fasting and caloric restriction464
The Achilles heel of TNBCs: Ferroptosis heterogeneity460
Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease436
The search for thermoregulatory neurons is heating up401
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle388
Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity356
Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis353
Unveiling adipose populations linked to metabolic health in obesity343
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial342
Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer313
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis311
Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity307
“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis297
Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities290
The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits282
DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication280
Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction265
mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination262
A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones258
The cephalic phase of insulin release is modulated by IL-1β253
Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis231
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression222
Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling211
Microvessels enhance vascularization and function of transplanted insulin-producing cells210
Creatine promotes metastatic dissemination205
Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage189
Kir2.1 channel: Macrophage plasticity in tumor microenvironment189
Sugar addiction: An Achilles’ heel of auto-immune diseases?189
Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues187
A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development187
Supercharging cancer-fighting T cells with lithium carbonate187
Sphingolipid metabolism controls mammalian heart regeneration182
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2181
Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments175
Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth174
FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption171
Mitochondrial membrane lipids in the regulation of bioenergetic flux170
Adhesion-mediated mechanosignaling forces mitohormesis169
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses165
PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy162
Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring161
Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness161
MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity160
EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis154
Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain153
Early prediction of incident liver disease using conventional risk factors and gut-microbiome-augmented gradient boosting150
Glutamate metabolism directs energetic trade-offs to shape host-pathogen susceptibility in Drosophila150
Evaluating human genetic support for hypothesized metabolic disease genes149
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH146
Amino acid is a major carbon source for hepatic lipogenesis143
Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation141
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells139
Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export137
Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways137
PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders136
Understanding the metabolism of infants using whole-body metabolic models135
Defend or reproduce? Muscle-derived glutamate determines an immune-reproductive energetic tradeoff134
Paraventricular glia drive circuit function to control metabolism132
Focus on diet and exercise127
Mitochondria ensure immune surveillance by retro-communication with the nucleus124
Targeting PDAC metabolism: Environment determines what has GOT2 give124
The crosstalk between bone remodeling and energy metabolism: A translational perspective123
Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial121
The past, present, and future physiology and pharmacology of glucagon121
Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism121
Testing the carbohydrate-insulin model: Short-term metabolic responses to consumption of meals with varying glycemic index in healthy adults119
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα118
Exosomes as mediators of intercellular crosstalk in metabolism117
Microbiome-derived metabolites counteract tumor-induced immunosuppression and boost immune checkpoint blockade116
Response to Paik et al. on the disease burden of NAFLD116
Biting into a union of oncology and metabolism through leukemic stem cells115
Anti-seizure effects of norepinephrine-induced free fatty acid release114
A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation111
Can tumor cells take it all away?111
Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance110
Famsin and fasting adaptation: A glucagon connection110
Understanding the variation in exercise responses to guide personalized physical activity prescriptions109
“Shunt-ing” down obesity with novel endogenous metabolites109
Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression108
Cardiovascular disease in diabetes, beyond glucose107
Liver microbes controlling immunity: Facts and pitfalls107
Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma106
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK104
Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1102
Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging102
Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma101
Emerging therapies in cancer metabolism101
Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment99
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity98
Acetate enables metabolic fitness and cognitive performance during sleep disruption97
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist96
Deciphering the metabolic heterogeneity of hematopoietic stem cells with single-cell resolution96
Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial94
Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment93
Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity92
Single-cell transcriptomic and spatial landscapes of the developing human pancreas92
Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies91
Beggars banquet: Metabolism in the tumor immune microenvironment and cancer therapy91
SLC25A48 controls mitochondrial choline import and metabolism91
Defying “IL-11ness” by inhibiting inflammation: Strategy for health and longevity89
The Gro3p factor: Restoring NAD+/NADH homeostasis to ameliorate mitochondrial disease89
Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling88
Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes85
Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome85
Fueling metabolic disruption via FMD to boost chemotherapy in TNBC84
Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals83
Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism83
Multi-organ transcriptome atlas of a mouse model of relative energy deficiency in sport83
Intracellular infection and immune system cues rewire adipocytes to acquire immune function82
The intersection of frailty and metabolism81
Top-down control of conditioned overconsumption is mediated by insular cortex Nos1 neurons81
GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway81
FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit80
Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance79
Diabetic retinopathy is a ceramidopathy reversible by anti-ceramide immunotherapy79
Molecular aspects of fructose metabolism and metabolic disease78
Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex76
OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy76
Urea cycle activation triggered by host-microbiota maladaptation driving colorectal tumorigenesis76
Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability74
A nutrigeroscience approach: Dietary macronutrients and cellular senescence74
The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency74
Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis74
Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism73
Not so neutral lipids: Metabolic regulation of the pre-metastatic niche72
Branching out beyond canonical brown adipocyte function71
Preventing metabolic disease: Part I71
Realigned transsulfuration drives BRAF-V600E-targeted therapy resistance in melanoma71
Vive la resistant starch: A potential treatment for metabolic dysfunction-associated steatohepatitis70
T cells critically depend on pyruvate oxidation70
Cytosolic pH is a direct nexus in linking environmental cues with insulin processing and secretion in pancreatic β cells70
Timed feeding aligns the adipocyte clock to optimize thermogenesis when eating a high-fat diet70
Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin69
Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis69
Pyruvate kinase M2 activation reprograms mitochondria in CD8 T cells, enhancing effector functions and efficacy of anti-PD1 therapy69
Microbiota-gut-brain axis drives overeating disorders68
Two independent respiratory chains adapt OXPHOS performance to glycolytic switch67
Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease67
Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance67
The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy67
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity66
NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging66
Integrating multiplex immunofluorescent and mass spectrometry imaging to map myeloid heterogeneity in its metabolic and cellular context66
Deoxyhypusine synthase promotes a pro-inflammatory macrophage phenotype66
Age-related ciliopathy: Obesogenic shortening of melanocortin-4 receptor-bearing neuronal primary cilia66
Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation65
The therapeutic promises of NAD+ boosters65
LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept64
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer64
Unlocking the power of postbiotics: A revolutionary approach to nutrition for humans and animals64
Hepatocyte CHRNA4 mediates the MASH-promotive effects of immune cell-produced acetylcholine and smoking exposure in mice and humans64
Fight, flight, and freeze!62
Metabolic programs tailor T cell immunity in viral infection, cancer, and aging62
Bempedoic acid suppresses diet-induced hepatic steatosis independently of ATP-citrate lyase62
SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment62
A dietary source of antibiotic tolerance61
Gut microbial alterations in arginine metabolism determine bone mechanical adaptation61
Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation61
A pattern emerges in chromatin aging: AP-1 steals the show61
Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging61
Diabesity? No worries, FKBP11 to the rescue61
Krebs takes a turn at cell differentiation61
Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 160
Outrunning obesity with Lac-Phe?60
Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming60
A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis60
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease60
Thymidine kinase 1 drives hepatocellular carcinoma in enzyme-dependent and -independent manners60
TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver58
T-bet B or not T-bet B, is that the question in obesity-related metabolic disease?58
The neurocircuitry of fasting-induced glucocorticoid release58
GLP-1/GIP/glucagon receptor triagonism gets its try in humans58
Synergistic role of gut-microbial L-ornithine in enhancing ustekinumab efficacy for Crohn’s disease57
Identification of a molecular resistor that controls UCP1-independent Ca2+ cycling thermogenesis in adipose tissue57
Leptin enhances the intracellular thyroid hormone activation in skeletal muscle to boost energy balance57
Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function57
A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion57
Short-term cold exposure induces persistent epigenomic memory in brown fat56
Inflammation and cholesterol at the crossroads of vascular risk56
m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP156
First we eat, then we do everything else: The dynamic metabolic regulation of efferocytosis54
The mitochondrial multi-omic response to exercise training across rat tissues54
Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease54
Targeting metabolic circuitry to supercharge CD8+ T cell antitumor responses54
Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation53
Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation53
TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis53
Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing53
Creatine promotes cancer metastasis through activation of Smad2/353
Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L152
Carbon source availability drives nutrient utilization in CD8+ T cells52
Region-specific transcriptomic responses to obesity and diabetes in macaque hypothalamus52
Peter J. Roach (1948–2022)50
Hepatic FXR-FGF4 is required for bile acid homeostasis via an FGFR4-LRH-1 signal node under cholestatic stress50
GDF15 analogs as obesity therapeutics50
Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia50
Immunoediting instructs tumor metabolic reprogramming to support immune evasion50
Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state50
Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST49
Making a sPLAsh: The expanding repertoire of EV signaling49
Transcriptomic, epigenomic, and spatial metabolomic cell profiling redefines regional human kidney anatomy49
Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance49
Circulating glycerate predicts resilience to fructose-induced hepatic steatosis49
Exercise induces tissue-specific adaptations to enhance cardiometabolic health48
Non-invasive lipid panel of MASLD fibrosis transition underscores the role of lipoprotein sulfatides in hepatic immunomodulation48
Stress-induced β cell early senescence confers protection against type 1 diabetes48
Eliminate or reformulate ultra-processed foods? Biological mechanisms matter48
Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease48
Acetate controls endothelial-to-mesenchymal transition47
Deoxyribonucleoside triphosphate pools in mammalian cells are expandable upon DNA damage47
Individual-specific functional epigenomics reveals genetic determinants of adverse metabolic effects of glucocorticoids47
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH47
Glucocorticoid resistance and hyperlactatemia: A tag team to worsen sepsis47
SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression46
Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes46
The DEAD Box Protein Mrh4 Functions in the Assembly of the Mitochondrial Large Ribosomal Subunit46
Protection from alcohol intoxication: Must be FGF21 to enter46
She didn’t start the fire: Mammary duct epithelial cells suppress adipocyte thermogenesis46
A distinct hypothalamus-to-β cell circuit modulates insulin secretion45
Separate gut-brain circuits for fat and sugar reinforcement combine to promote overeating45
Can we talk? The cryptic communications of hepatic stellate cells in lipid metabolism45
Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples45
Mitohormesis45
A purine metabolic checkpoint that prevents autoimmunity and autoinflammation45
FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity45
Physiologic disruption and metabolic reprogramming in infection and sepsis44
The browning and mobilization of subcutaneous white adipose tissue supports efficient skin repair44
The mitochondrial unfolded protein response regulates hippocampal neural stem cell aging44
Feasibility of time-restricted eating and impacts on cardiometabolic health in 24-h shift workers: The Healthy Heroes randomized control trial44
Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection43
Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity43
NSUN2 is a glucose sensor suppressing cGAS/STING to maintain tumorigenesis and immunotherapy resistance42
Colonic macrophages eat and feed42
Embracing the unknown: Proteomic insights into the human microbiome42
Fecal microbiota transplantation in human metabolic diseases: From a murky past to a bright future?42
SREBP1c-PARP1 axis tunes anti-senescence activity of adipocytes and ameliorates metabolic imbalance in obesity42
The effects of obesity and metabolic abnormalities on severe COVID-19-related outcomes after vaccination: A population-based study42
Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice42
Extracellular HSP90 warms up integrins for an irisin workout42
Multi-omic human pancreatic islet endoplasmic reticulum and cytokine stress response mapping provides type 2 diabetes genetic insights42
Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment41
The hormesis principle of neuroplasticity and neuroprotection41
PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL241
Dysfunctional circadian clock accelerates cancer metastasis by intestinal microbiota triggering accumulation of myeloid-derived suppressor cells41
Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-241
Impact of biological sex and sex hormones on molecular signatures of skeletal muscle at rest and in response to distinct exercise training modes41
Molecular and metabolic heterogeneity of astrocytes and microglia41
Meta-hallmarks of aging and cancer40
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