Cell Metabolism

Article	Citations
The Metabolic Underpinnings of Ferroptosis	729
The hallmarks of cancer metabolism: Still emerging	541
CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability	453
The Role of HIF in Immunity and Inflammation	375
Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity	335
Exosomes as mediators of intercellular crosstalk in metabolism	330
Why does obesity cause diabetes?	308
Metabolic-Pathway-Based Subtyping of Triple-Negative Breast Cancer Reveals Potential Therapeutic Targets	264
Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming	260
SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution	256
SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment	254
Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease	253
Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer	236
Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects	230
Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism	227
Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease	226
The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine	223
Gut-liver axis: Pathophysiological concepts and clinical implications	221
FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption	218
The global burden of metabolic disease: Data from 2000 to 2019	218
Mitochondrial signal transduction	211
Astrocyte-neuron metabolic cooperation shapes brain activity	210
Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes	202
The Power of Plasticity—Metabolic Regulation of Hepatic Stellate Cells	197
Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity	196

Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning	193
Plasticity of Epididymal Adipose Tissue in Response to Diet-Induced Obesity at Single-Nucleus Resolution	192
Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis	189
Quantitative Fluxomics of Circulating Metabolites	189
Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance	179
Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy	176
A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis	174
The Gut Microbiota at the Service of Immunometabolism	171
MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice	168
Meta-hallmarks of aging and cancer	165
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context	165
Mechanoresponsive metabolism in cancer cell migration and metastasis	161
NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion	157
The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia	157
The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure	156
The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling	154
Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth	153
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease	150
The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer	149
Efferocytosis induces macrophage proliferation to help resolve tissue injury	145
The role of lipids in cancer progression and metastasis	142
SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells	142
Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2	140
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα	140
Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases	139
High-fiber diet mitigates maternal obesity-induced cognitive and social dysfunction in the offspring via gut-brain axis	139
Sphingolipids in metabolic disease: The good, the bad, and the unknown	139
Molecular aspects of fructose metabolism and metabolic disease	139
Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages	137
Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19	136
Metabolic orchestration of the wound healing response	136
KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease	135
Evolving concepts in NAD+ metabolism	134
Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers	132
Immunometabolism in the Single-Cell Era	132
Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment	131
Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy	130
SARS-CoV-2 infection induces beta cell transdifferentiation	128
Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process	125
Platelets Facilitate the Wound-Healing Capability of Mesenchymal Stem Cells by Mitochondrial Transfer and Metabolic Reprogramming	125
Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing	124
Tryptophan metabolism in health and disease	120
The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease	120
Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue	118
Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo	118
Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes	116
LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept	114
The Evolving Landscape of Noncanonical Functions of Metabolic Enzymes in Cancer and Other Pathologies	114
The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation	114
Hypothalamic detection of macronutrients via multiple gut-brain pathways	114

Fecal microbiota transplantation in human metabolic diseases: From a murky past to a bright future?	112
Insulin Treatment Is Associated with Increased Mortality in Patients with COVID-19 and Type 2 Diabetes	112
Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells	111
Cardiovascular disease in diabetes, beyond glucose	109
Mapping the single-cell transcriptomic response of murine diabetic kidney disease to therapies	109
Microbiota alterations in proline metabolism impact depression	109
Current Concepts, Opportunities, and Challenges of Gut Microbiome-Based Personalized Medicine in Nonalcoholic Fatty Liver Disease	107
Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis	106
Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin	105
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist	104
Mitochondria Define Intestinal Stem Cell Differentiation Downstream of a FOXO/Notch Axis	104
Warmth Prevents Bone Loss Through the Gut Microbiota	104
Pyruvate Kinase Controls Signal Strength in the Insulin Secretory Pathway	103
Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis	102
Hypothalamic bile acid-TGR5 signaling protects from obesity	102
NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis	101
Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism	99
The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity	99
Biological age is increased by stress and restored upon recovery	97
Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication	96
Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition	96
Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis	96
Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis	96
The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming	95
Senescent immune cells release grancalcin to promote skeletal aging	95
Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion	94
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism	94
A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy	93
Apaf-1 Pyroptosome Senses Mitochondrial Permeability Transition	93
The role of hepatokines in NAFLD	92
Obesity Impairs Short-Term and Working Memory through Gut Microbial Metabolism of Aromatic Amino Acids	92
GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates	92
A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance	91
TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis	90
The Neutrophil-to-Lymphocyte Ratio Determines Clinical Efficacy of Corticosteroid Therapy in Patients with COVID-19	89
The Source of Glycolytic Intermediates in Mammalian Tissues	88
Comprehensive single-cell transcriptional profiling defines shared and unique epithelial injury responses during kidney fibrosis	87
Mitochondrial Oxidative Damage Underlies Regulatory T Cell Defects in Autoimmunity	87
Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation	86
A kidney perspective on the mechanism of action of sodium glucose co-transporter 2 inhibitors	86
CRISPR screens in physiologic medium reveal conditionally essential genes in human cells	86
The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function	86
C9orf72 regulates energy homeostasis by stabilizing mitochondrial complex I assembly	86
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity	85
Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging	83
Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension	83
Feasibility of time-restricted eating and impacts on cardiometabolic health in 24-h shift workers: The Healthy Heroes randomized control trial	83
Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia	83
Adhesion-mediated mechanosignaling forces mitohormesis	83
“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis	83
Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis	81
OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy	81
Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells	81
Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance	80
Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity	79
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity	77
Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans	77
Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease	77
Glial Metabolic Rewiring Promotes Axon Regeneration and Functional Recovery in the Central Nervous System	77
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses	77
Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape	76
Creatine promotes cancer metastasis through activation of Smad2/3	76
Increased fidelity of protein synthesis extends lifespan	75
Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis	75
Direct and indirect control of hepatic glucose production by insulin	75
Global Burden of Disease Study 2019 suggests that metabolic risk factors are the leading drivers of the burden of ischemic heart disease	74
A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes	74
Carbon source availability drives nutrient utilization in CD8+ T cells	73
PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease	73
Insulin action in adipocytes, adipose remodeling, and systemic effects	72
Circadian rhythms and the gut microbiome synchronize the host’s metabolic response to diet	71
Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer	70
Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle	70
Distinct properties of adipose stem cell subpopulations determine fat depot-specific characteristics	68
Metabolic cycles and signals for insulin secretion	68
Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer	67
Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis	67
Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma	65
Metabolic stress drives sympathetic neuropathy within the liver	65
Human skeletal muscle CD90+ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients	65

Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial	64
Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3	64
TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation	64
Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease	63
GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment	62
Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation	62
A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation	62
Interferon-α-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity	61
Ablation of Fat Cells in Adult Mice Induces Massive Bone Gain	61
Mitohormesis in Hypothalamic POMC Neurons Mediates Regular Exercise-Induced High-Turnover Metabolism	60
Eliminate or reformulate ultra-processed foods? Biological mechanisms matter	60
Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity	60
FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping	60
Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction	59
Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood	59
IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2	58
Food colorants metabolized by commensal bacteria promote colitis in mice with dysregulated expression of interleukin-23	58
Metabolic programs tailor T cell immunity in viral infection, cancer, and aging	58
Brain glycogen serves as a critical glucosamine cache required for protein glycosylation	57
Central Ceramide Signaling Mediates Obesity-Induced Precocious Puberty	57
Hyodeoxycholic acid alleviates non-alcoholic fatty liver disease through modulating the gut-liver axis	57
The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy	56
A methionine-Mettl3-N-methyladenosine axis promotes polycystic kidney disease	56
A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells	56
Fatty acid overproduction by gut commensal microbiota exacerbates obesity	56
Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging	55
Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis	55
Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells	55
Late isocaloric eating increases hunger, decreases energy expenditure, and modifies metabolic pathways in adults with overweight and obesity	55
Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression	54
MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH	54
Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1	54
Adipose tissue at single-cell resolution	54
Aging Reprograms the Hematopoietic-Vascular Niche to Impede Regeneration and Promote Fibrosis	54
A newly identified protein from Akkermansia muciniphila stimulates GLP-1 secretion	54
Multi-Tissue Acceleration of the Mitochondrial Phosphoenolpyruvate Cycle Improves Whole-Body Metabolic Health	53
The crosstalk between bone remodeling and energy metabolism: A translational perspective	52
Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health	52
Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes	52
Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila	52
FGF1 and insulin control lipolysis by convergent pathways	51
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial	51
Tumor aerobic glycolysis confers immune evasion through modulating sensitivity to T cell-mediated bystander killing via TNF-α	50
Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer	50
Astrocytic urea cycle detoxifies Aβ-derived ammonia while impairing memory in Alzheimer’s disease	49
Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells	49
Tanycytes control hypothalamic liraglutide uptake and its anti-obesity actions	49
Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism	49
NAD precursors cycle between host tissues and the gut microbiome	49
The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits	48
Mitochondrial fragmentation and donut formation enhance mitochondrial secretion to promote osteogenesis	48
Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1	48
Neuregulin 4 suppresses NASH-HCC development by restraining tumor-prone liver microenvironment	47
A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis	47
SREBP1c-PARP1 axis tunes anti-senescence activity of adipocytes and ameliorates metabolic imbalance in obesity	47
Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation	47
Diurnal transcriptome landscape of a multi-tissue response to time-restricted feeding in mammals	46
3D chromatin maps of the human pancreas reveal lineage-specific regulatory architecture of T2D risk	46
Cancer cell-intrinsic XBP1 drives immunosuppressive reprogramming of intratumoral myeloid cells by promoting cholesterol production	46
Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment	46
A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis	46
A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis	45
PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy	45
Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection	45
Metabolic diversity within breast cancer brain-tropic cells determines metastatic fitness	45
DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing	45
Metabolite discovery: Biochemistry’s scientific driver	44
Caloric Restriction Promotes Immunometabolic Reprogramming Leading to Protection from Tuberculosis	44
Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state	44
Microenvironmental ammonia enhances T cell exhaustion in colorectal cancer	44
Timing of daily calorie loading affects appetite and hunger responses without changes in energy metabolism in healthy subjects with obesity	44
Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation	44
Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake	43
Hypothalamic astrocytes control systemic glucose metabolism and energy balance	43
Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation	43
FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit	43
The requirement for pyruvate dehydrogenase in leukemogenesis depends on cell lineage	43
Central glucagon-like peptide 1 receptor activation inhibits Toll-like receptor agonist-induced inflammation	43
A distinct hypothalamus-to-β cell circuit modulates insulin secretion	43
Emerging targetome and signalome landscape of gut microbial metabolites	43
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer	42
Fasting blood glucose as a predictor of mortality: Lost in translation	42
Coenzyme A fuels T cell anti-tumor immunity	42
Mosaic dysfunction of mitophagy in mitochondrial muscle disease	42
Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans	42
The past, present, and future physiology and pharmacology of glucagon	41
Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells	41
Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species	41
Emerging therapies in cancer metabolism	41
An Upstream Open Reading Frame in Phosphatase and Tensin Homolog Encodes a Circuit Breaker of Lactate Metabolism	41
Quantitative Analysis of the Physiological Contributions of Glucose to the TCA Cycle	40
Early prediction of incident liver disease using conventional risk factors and gut-microbiome-augmented gradient boosting	40
Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis	40
Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment	40
Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1	40