Cell Metabolism

Article	Citations
The secret life of lactate: A novel cell-cycle regulatory mechanism	1036
Cap CASP, not SCAP, to fight steatohepatitis	700
Sex- and timing-specific effects of fasting and caloric restriction	655
Adipocyte-derived extracellular vesicles are key regulators of central leptin sensitivity and energy homeostasis	600
The Achilles heel of TNBCs: Ferroptosis heterogeneity	592
DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication	551
The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits	470
Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis	444
Unveiling adipose populations linked to metabolic health in obesity	424
Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer	413
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle	378
Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities	305
Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease	294
Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity	291
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial	257
Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction	243
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis	239
Supercharging cancer-fighting T cells with lithium carbonate	238
mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination	227
Sugar addiction: An Achilles’ heel of auto-immune diseases?	222
Kir2.1 channel: Macrophage plasticity in tumor microenvironment	210
Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage	209
The cephalic phase of insulin release is modulated by IL-1β	208
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2	202
Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness	198

Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling	183
Nutrient allocation fuels T cell-mediated immunity	182
Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues	182
PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy	179
A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development	179
Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments	176
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression	175
Mitochondrial membrane lipids in the regulation of bioenergetic flux	170
A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones	170
The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury	170
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses	166
Sphingolipid metabolism controls mammalian heart regeneration	162
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH	150
EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis	150
Digital twins for in vivo metabolic flux estimations in patients with brain cancer	149
Paraventricular glia drive circuit function to control metabolism	147
Focus on diet and exercise	147
Understanding the metabolism of infants using whole-body metabolic models	146
Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain	145
Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring	144
Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation	142
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells	142
Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication	142
Testing the carbohydrate-insulin model: Short-term metabolic responses to consumption of meals with varying glycemic index in healthy adults	141
The past, present, and future physiology and pharmacology of glucagon	140
HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes	137
Targeting PDAC metabolism: Environment determines what has GOT2 give	136
The crosstalk between bone remodeling and energy metabolism: A translational perspective	135
MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity	134
Early prediction of incident liver disease using conventional risk factors and gut-microbiome-augmented gradient boosting	134
Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism	133
PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders	132
Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways	130
Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export	130
Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial	128
Evaluating human genetic support for hypothesized metabolic disease genes	127
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα	127
Famsin and fasting adaptation: A glucagon connection	125
Amino acid is a major carbon source for hepatic lipogenesis	125
Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis	119
Biting into a union of oncology and metabolism through leukemic stem cells	119
Anti-seizure effects of norepinephrine-induced free fatty acid release	111
Microbiome-derived metabolites counteract tumor-induced immunosuppression and boost immune checkpoint blockade	111
Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies	111
“Shunt-ing” down obesity with novel endogenous metabolites	110
Response to Paik et al. on the disease burden of NAFLD	106
Deciphering the metabolic heterogeneity of hematopoietic stem cells with single-cell resolution	105
Liver microbes controlling immunity: Facts and pitfalls	105
Lighting up arginine metabolism reveals its functional diversity in physiology and pathology	105
Beggars banquet: Metabolism in the tumor immune microenvironment and cancer therapy	104

Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment	104
Single-cell transcriptomic and spatial landscapes of the developing human pancreas	102
Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial	101
Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma	101
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist	101
Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression	99
Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity	98
Acetate enables metabolic fitness and cognitive performance during sleep disruption	97
Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment	96
Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma	96
Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance	96
A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation	96
Emerging therapies in cancer metabolism	95
Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging	94
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity	94
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK	92
Understanding the variation in exercise responses to guide personalized physical activity prescriptions	92
Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1	92
Diabetic retinopathy is a ceramidopathy reversible by anti-ceramide immunotherapy	91
Intracellular infection and immune system cues rewire adipocytes to acquire immune function	90
Multi-organ transcriptome atlas of a mouse model of relative energy deficiency in sport	90
Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome	90
Missed signals: How PET imaging may fail to capture the addictive potential of ultra-processed foods	88
Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance	87
A nutrigeroscience approach: Dietary macronutrients and cellular senescence	87
Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes	85
Urea cycle activation triggered by host-microbiota maladaptation driving colorectal tumorigenesis	85
GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway	85
Fueling metabolic disruption via FMD to boost chemotherapy in TNBC	84
Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability	84
Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling	84
Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex	84
The intersection of frailty and metabolism	83
Defying “IL-11ness” by inhibiting inflammation: Strategy for health and longevity	83
Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism	83
Does sweet turn sour? How aspartame aggravates atherosclerosis in a preclinical model	83
Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals	83
SLC25A48 controls mitochondrial choline import and metabolism	82
FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit	82
The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency	82
Branching out beyond canonical brown adipocyte function	81
Preventing metabolic disease: Part I	81
OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy	81
Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin	80
Macrophage PD-1 regulates energy expenditure and metabolic dysfunction under immune checkpoint blockade	80
Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease	80
Timed feeding aligns the adipocyte clock to optimize thermogenesis when eating a high-fat diet	80
The NARly side of whole-body NAD homeostasis	79
Extracellular vesicles from obese visceral adipose promote pancreatic cancer development and resistance to immune checkpoint blockade therapy	78
Realigned transsulfuration drives BRAF-V600E-targeted therapy resistance in melanoma	78
Scale-spanning crosstalk between metabolism and information processing	78
NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging	78
Vive la resistant starch: A potential treatment for metabolic dysfunction-associated steatohepatitis	78
Body-wide multi-omic counteraction of aging with GLP-1R agonism	77
Not so neutral lipids: Metabolic regulation of the pre-metastatic niche	76
Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism	76
Cytosolic pH is a direct nexus in linking environmental cues with insulin processing and secretion in pancreatic β cells	75
Hepatocyte CHRNA4 mediates the MASH-promotive effects of immune cell-produced acetylcholine and smoking exposure in mice and humans	75
NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging	75
Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance	75
Age-related ciliopathy: Obesogenic shortening of melanocortin-4 receptor-bearing neuronal primary cilia	75
Two independent respiratory chains adapt OXPHOS performance to glycolytic switch	75
Pyruvate kinase M2 activation reprograms mitochondria in CD8 T cells, enhancing effector functions and efficacy of anti-PD1 therapy	74
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer	73
Metabolic programs tailor T cell immunity in viral infection, cancer, and aging	72
Microbiota-gut-brain axis drives overeating disorders	72
FGF21 reverses MASH through coordinated actions on the CNS and liver	71
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity	71
Paternal exercise confers endurance capacity to offspring through sperm microRNAs	71
LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept	71
Integrating multiplex immunofluorescent and mass spectrometry imaging to map myeloid heterogeneity in its metabolic and cellular context	70
Krebs takes a turn at cell differentiation	70
Unlocking the power of postbiotics: A revolutionary approach to nutrition for humans and animals	70
Genetics-nutrition interactions control diurnal enhancer-promoter dynamics and liver lipid metabolism	69
Outrunning obesity with Lac-Phe?	69
Fight, flight, and freeze!	68
Thymidine kinase 1 drives hepatocellular carcinoma in enzyme-dependent and -independent manners	68
Gut microbial alterations in arginine metabolism determine bone mechanical adaptation	68
A pattern emerges in chromatin aging: AP-1 steals the show	68
Bempedoic acid suppresses diet-induced hepatic steatosis independently of ATP-citrate lyase	68

A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis	68
Diabesity? No worries, FKBP11 to the rescue	68
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease	67
Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function	67
Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation	67
GLP-1/GIP/glucagon receptor triagonism gets its try in humans	67
Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1	67
Identification of a molecular resistor that controls UCP1-independent Ca2+ cycling thermogenesis in adipose tissue	66
m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1	66
TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver	66
T-bet B or not T-bet B, is that the question in obesity-related metabolic disease?	66
A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion	66
Inflammation and cholesterol at the crossroads of vascular risk	66
Toward the next 20 years of Cell Metabolism	66
Immunoediting instructs tumor metabolic reprogramming to support immune evasion	65
Carbon source availability drives nutrient utilization in CD8+ T cells	65
Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia	65
Targeting metabolic circuitry to supercharge CD8+ T cell antitumor responses	64
Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1	64
TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis	64
Leptin enhances the intracellular thyroid hormone activation in skeletal muscle to boost energy balance	64
Short-term cold exposure induces persistent epigenomic memory in brown fat	63
The mitochondrial multi-omic response to exercise training across rat tissues	63
The neurocircuitry of fasting-induced glucocorticoid release	63
Synergistic role of gut-microbial L-ornithine in enhancing ustekinumab efficacy for Crohn’s disease	63
Region-specific transcriptomic responses to obesity and diabetes in macaque hypothalamus	63
Hepatic FXR-FGF4 is required for bile acid homeostasis via an FGFR4-LRH-1 signal node under cholestatic stress	62
Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation	62
Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation	62
Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease	62
Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state	62
Reassessment of antibody-based detection of the murine T cell GLP-1 receptor	61
Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance	61
Non-invasive lipid panel of MASLD fibrosis transition underscores the role of lipoprotein sulfatides in hepatic immunomodulation	61
GDF15 analogs as obesity therapeutics	61
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH	61
Acetate controls endothelial-to-mesenchymal transition	60
Circulating glycerate predicts resilience to fructose-induced hepatic steatosis	60
Gut enteroendocrine cell activation using a combination of GPR119 and GPR40 agonists results in synergistic hormone secretion in mice and humans	60
Peter J. Roach (1948–2022)	59
Making a sPLAsh: The expanding repertoire of EV signaling	59
Transcriptomic, epigenomic, and spatial metabolomic cell profiling redefines regional human kidney anatomy	58
Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender	58
Exercise induces tissue-specific adaptations to enhance cardiometabolic health	57
The DEAD Box Protein Mrh4 Functions in the Assembly of the Mitochondrial Large Ribosomal Subunit	57
She didn’t start the fire: Mammary duct epithelial cells suppress adipocyte thermogenesis	57
Deoxyribonucleoside triphosphate pools in mammalian cells are expandable upon DNA damage	57
Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST	57
Stress-induced β cell early senescence confers protection against type 1 diabetes	57
Time to exercise! Boosting exercise performance via AMPK signaling	56
Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples	56
A purine metabolic checkpoint that prevents autoimmunity and autoinflammation	56
Imidazole propionate: Cause and cure in atherosclerosis?	56
Glycogen shepherd guides the hidden trail of pentose phosphate pathway	56
Protection from alcohol intoxication: Must be FGF21 to enter	56
Leveraging genetic and phenotypic variation to discover metabolite-protein interactions	56
Can we talk? The cryptic communications of hepatic stellate cells in lipid metabolism	56
Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes	56
FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity	55
Mitochondrial dysfunction reveals H2S-mediated synaptic sulfhydration as a potential mechanism for autism-associated social defects	55
A distinct hypothalamus-to-β cell circuit modulates insulin secretion	54
The browning and mobilization of subcutaneous white adipose tissue supports efficient skin repair	54
SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression	54
Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection	53
Physiologic disruption and metabolic reprogramming in infection and sepsis	53
Separate gut-brain circuits for fat and sugar reinforcement combine to promote overeating	53
The effects of obesity and metabolic abnormalities on severe COVID-19-related outcomes after vaccination: A population-based study	53
Feasibility of time-restricted eating and impacts on cardiometabolic health in 24-h shift workers: The Healthy Heroes randomized control trial	53
Mitohormesis	53
Multi-omic human pancreatic islet endoplasmic reticulum and cytokine stress response mapping provides type 2 diabetes genetic insights	53
Colonic macrophages eat and feed	53
NSUN2 is a glucose sensor suppressing cGAS/STING to maintain tumorigenesis and immunotherapy resistance	53
The mitochondrial unfolded protein response regulates hippocampal neural stem cell aging	53
Extracellular HSP90 warms up integrins for an irisin workout	53
Nicotinic acid riboside maintains NAD+ homeostasis and ameliorates aging-associated NAD+ decline	52
Adipose whispers to mast cells for accelerating immune evasion in pancreatic cancer	52
An “electric” microbial cue to control food intake behavior	52
Dysfunctional circadian clock accelerates cancer metastasis by intestinal microbiota triggering accumulation of myeloid-derived suppressor cells	51
Embracing the unknown: Proteomic insights into the human microbiome	50
Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV	50
The hormesis principle of neuroplasticity and neuroprotection	49
Meta-hallmarks of aging and cancer	49
Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment	49
Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease	49
Impact of biological sex and sex hormones on molecular signatures of skeletal muscle at rest and in response to distinct exercise training modes	49
PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2	49
Homocysitaconate controls inflammation through reshaping methionine metabolism and N-homocysteinylation	48
SREBP1c-PARP1 axis tunes anti-senescence activity of adipocytes and ameliorates metabolic imbalance in obesity	48
Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation	48
Molecular and metabolic heterogeneity of astrocytes and microglia	48
High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate	48
Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses	47
Acetylated cellulose suppresses body mass gain through gut commensals consuming host-accessible carbohydrates	47
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity	47
Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury	46